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- Cesari, Italo M., et al. Show all 4 Authors
- Parasitology international 2016 v.65 no.3 pp. 191-195
- Schistosoma mansoni; adults; affinity chromatography; antigens; cathepsin B; diagnostic techniques; digestive system; hemoglobin; ion exchange; parasites; patients; polyclonal antibodies; proteolysis; rabbits; schistosomiasis
- ... Adult Schistosoma mansoni parasites have the capacity to degrade ingested host hemoglobin and other host plasma proteins by using a series of gut proteolytic enzymes, including cathepsin B; this enzyme is released to the host intravascular environment during regurgitations of adult worms. Cathepsin B becomes thus a circulating parasite component that has been shown to be specifically recognized as ...
- Cesari, Italo M., et al. Show all 6 Authors
- Molecular and biochemical parasitology 2011 v.179 no.1 pp. 18-29
- Schistosoma; blood flow; calcium; carboxypeptidases; dextran; endocytosis; epithelium; erythrocytes; esophagus; hemoglobin; iron; lysosomes; nutrient uptake; parasitology; proline; proteinase inhibitors; proteinases; proteomics; transport proteins
- ... Whilst the schistosome tegument has been intensively studied there is little information about processes in the gut, the other major interface with the bloodstream, apart from the well characterised cascade of proteases involved in haemoglobin digestion. To gain insights into gut function we undertook a proteomic analysis of worm vomitus and performed in vitro erythrocyte feeding experiments. Addi ...