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- Hashii, Noritaka, et al. Show all 20 Authors
- Biologicals 2013 v.41 pp. 355-363
- anticoagulant activity; anticoagulants; chondroitin sulfate; dialysis; disseminated intravascular coagulation; fluorescent labeling; galactosamine; glucosamine; heparin; high performance liquid chromatography; ingredients; intestines; sodium; swine; thrombosis
- ... Heparin is a sulfated glycosaminoglycan (GAG), which contains N-acetylated or N-sulfated glucosamine (GlcN). Heparin, which is generally obtained from the healthy porcine intestines, is widely used as an anticoagulant during dialysis and treatments of thrombosis such as disseminated intravascular coagulation. Dermatan sulfate (DS) and chondroitin sulfate (CS), which are galactosamine (GalN)-contai ...
- Hashii, Noritaka, et al. Show all 24 Authors
- Biologicals 2013 v.41 pp. 415-423
- anticoagulant activity; anticoagulants; bioassays; calcium; heparin; quality control; sodium
- ... Heparin is used as an anticoagulant drug. The anticoagulation process is mainly caused by the interaction of heparin with antithrombin followed by inhibition of anticoagulant factor IIa and factor Xa. The anti-factor IIa and anti-factor Xa activities of heparin are critical for its anticoagulant effect; however, physicochemical methods that can reflect these activities have not been established. T ...