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1. A comparison between high carbohydrate and high lipid diets reception on the growth, feed utilization and glucose homeostasis of genetically improved farmed tilapia Oreochromis niloticus

Author:
Kang-Wei Wang; Jun-Xing Chen; Qin-Qin Liu; Xin Deng; Li Luo; Shi-Mei Lin; Yong-Jun Chen
Source:
Aquaculture reports 2022 v.24 pp. 101119
ISSN:
2352-5134
Subject:
Oreochromis niloticus; acetyl-CoA carboxylase; aquaculture; blood glucose; body weight; carboxy-lyases; dietary carbohydrate; energy density; fatty-acid synthase; feed conversion; gene expression; gluconeogenesis; glucose; glucose transporters; glucose-6-phosphatase; glycogen; glycogen (starch) synthase; glycogenesis; glycogenolysis; glycolysis; growth performance; high carbohydrate diet; high fat diet; homeostasis; hyperglycemia; lipids; lipogenesis; liver; protein efficiency ratio; protein subunits; proximate composition; satiety; starch
Abstract:
... This study was performed to compare the effects of high carbohydrate and high lipid diets reception on the growth, feed utilization and glucose homeostasis of genetically improved farmed tilapia Oreochromis niloticus. Three isonitrogenous (ca 30.2% protein) diets were formulated with different levels of starch and lipid: the control (CON, 24.2% starch and 6.57% lipid), high carbohydrate diet (HCD, ...
DOI:
10.1016/j.aqrep.2022.101119

2. A high-fat diet alters lipid accumulation and oxidative stress and reduces the disease resistance of overwintering hybrid yellow catfish (Pelteobagrus fulvidraco♀×P. vachelli♂)

Author:
Shuzhan Fei; Yu Xia; Zheng Chen; Cui Liu; Haokun Liu; Dong Han; Junyan Jin; Yunxia Yang; Xiaoming Zhu; Shouqi Xie
Source:
Aquaculture reports 2022 v.23 pp. 101043
ISSN:
2352-5134
Subject:
Pelteobagrus; Tachysurus fulvidraco; Toll-like receptor 2; aquaculture; body weight; cortisol; crude protein; dietary fat; disease resistance; fish; gene expression; high fat diet; hybrids; immune response; inflammation; interleukin-10; kidneys; lipid content; lipids; lipogenesis; lipolysis; liver; lysozyme; malondialdehyde; overwintering; oxidative stress; spleen; superoxide dismutase; survival rate; transcription (genetics)
Abstract:
... This study was carried out to investigate the influence of dietary lipid levels on the growth, immune response, and disease resistance of hybrid yellow catfish (Pelteobagrus fulvidraco♀×P. vachelli♂) during overwintering. Yellow catfish (initial body weight: 49.42 ± 1.33 g) were fed isonitrogenous diets (crude protein 40%) with three lipid levels (low lipid: 8.57%, medium lipid: 12.65%, and high l ...
DOI:
10.1016/j.aqrep.2022.101043

3. A ketogenic diet attenuates acute and chronic ischemic kidney injury and reduces markers of oxidative stress and inflammation

Author:
Pedro Rojas-Morales; Juan Carlos León-Contreras; Mónica Sánchez-Tapia; Alejandro Silva-Palacios; Agustina Cano-Martínez; Susana González-Reyes; Angélica Saraí Jiménez-Osorio; Rogelio Hernández-Pando; Horacio Osorio-Alonso; Laura Gabriela Sánchez-Lozada; Armando R. Tovar; José Pedraza-Chaverri; Edilia Tapia
Source:
Life sciences 2022 v.289 pp. 120227
ISSN:
0024-3205
Subject:
Western blotting; acetylation; antioxidants; blood flow; fibrosis; high fat diet; histology; inflammation; interleukin-6; ischemia; ketogenic diet; ketone bodies; kidneys; liver; nephroprotective effect; oxidative stress; therapeutics
Abstract:
... Ischemic kidney injury is a common clinical condition resulting from transient interruption of the kidney's normal blood flow, leading to oxidative stress, inflammation, and kidney dysfunction. The ketogenic diet (KD), a low-carbohydrate, high-fat diet that stimulates endogenous ketone body production, has potent antioxidant and anti-inflammatory effects in distinct tissues and might thus protect ...
DOI:
10.1016/j.lfs.2021.120227

4. A network pharmacology-based strategy to explore the pharmacological mechanisms of Antrodia camphorata and antcin K for treating type II diabetes mellitus

Author:
Yi Kuang; Yue Chai; Huifei Su; Jen-Yu Lo; Xue Qiao; Min Ye
Source:
Phytomedicine 2022 v.96 pp. 153851
ISSN:
0944-7113
Subject:
Taiwanofungus camphoratus; adiponectin; blood serum; carbohydrate metabolism; fungi; glucose; glucose tolerance tests; high fat diet; insulin; insulin resistance; interleukin-6; leptin; mortality; pharmacology; quality of life
Abstract:
... Diabetes mellitus is a chronic carbohydrate metabolism disorder, which could develop a series of complications and thus lead to poor quality of life or even mortality. Antrodia camphorata is a rare parasitic fungus and has been proven to be effective for treating type II diabetes.This study aims to evaluate the anti-diabetic activities of A. camphorata and its main compound antcin K, as well as to ...
DOI:
10.1016/j.phymed.2021.153851

5. A polysaccharide from Rosa roxburghii Tratt fruit attenuates high-fat diet-induced intestinal barrier dysfunction and inflammation in mice by modulating the gut microbiota

Author:
Lei Wang; Pan Zhang; Chao Li; Fei Xu; Jie Chen
Source:
Food & function 2022 v.13 no.2 pp. 530-547
ISSN:
2042-650X
Subject:
Bacteroidetes; Rosa roxburghii; Ruminococcaceae; anti-inflammatory agents; blood serum; colitis; colorectal neoplasms; cytokines; diabetes; dysbiosis; fruits; high fat diet; inflammation; intestinal microorganisms; intestines; lactic acid; lipopolysaccharides; occludins; oxidative stress; permeability; tight junctions
Abstract:
... Obesity-induced colonic inflammation-stimulated colitis is one of the main causes of colorectal cancer. Dietary polysaccharides are considered an effective agent for relieving obesity-induced inflammatory diseases such as diabetes and colitis. In this work, the protective effects of a polysaccharide (RTFP) extracted from Rosa roxburghii Tratt fruit on barrier dysfunction and inflammation were inve ...
DOI:
10.1039/d1fo03190b

6. A polysaccharide isolated from Ganoderma lucidum ameliorates hyperglycemia through modulating gut microbiota in type 2 diabetic mice

Author:
Weiming Shao; Chun Xiao; Tianqiao Yong; Yifan Zhang; Huiping Hu; Ting Xie; Rongjie Liu; Longhua Huang; Xiangmin Li; Yizhen Xie; Jumei Zhang; Shaodan Chen; Manjun Cai; Diling Chen; Yuanchao Liu; Xiong Gao; Qingping Wu
Source:
International journal of biological macromolecules 2022 v.197 pp. 23-38
ISSN:
0141-8130
Subject:
Bacteroides; Ganoderma lucidum; Lactobacillus; Ruminococcaceae; blood glucose; endotoxins; fermentation; genes; glucose; glycogen; high fat diet; hyperglycemia; inflammation; insulin; insulin resistance; insulin secretion; intestinal microorganisms; intestines; liver; noninsulin-dependent diabetes mellitus; streptozotocin
Abstract:
... In this study, we reported a thermal stable and non-toxic heteropolysaccharide F31, which decreased the blood glucose of diabetic mice (21.75 mmol/L) induced by high-fat diet (HFD) and streptozotocin (STZ) to 12.56 and 15.18 mmol/L (P < 0.01) at 180 and 60 mg/kg, depicting remarkable hypoglycemic effects of 42.25 and 30.21%. Moreover, F31 repaired islet cells and increased insulin secretion, promo ...
DOI:
10.1016/j.ijbiomac.2021.12.034

7. Abnormal histidine metabolism promotes macrophage lipid accumulation under Ox-LDL condition

Author:
Baoling Zhu; Zhiwei Zhang; Xiangfei Wang; Weiwei Zhang; Hongyu Shi; Zhifeng Song; Suling Ding; Xiangdong Yang
Source:
Biochemical and biophysical research communications 2022 v.588 pp. 161-167
ISSN:
0006-291X
Subject:
antagonists; cholesterol; esterification; fat intake; genes; high fat diet; histamine; histidine; histidine decarboxylase; hydrolases; lipid metabolism; low density lipoprotein; macrophages; metabolic diseases; microarray technology; models; oxidation; oxidative stress; research
Abstract:
... Distinct macrophage populations exert highly heterogeneity and perform various functions, among which, a crucial function of lipid metabolism is highlighted. However, the role of histidine metabolism disorder in macrophage lipid metabolism remains elusive. Addressed this question, we sorted and cultured the bone marrow-derived macrophages (BMDMs) of histidine decarboxylase (Hdc) knockout (Hdc⁻/⁻) ...
DOI:
10.1016/j.bbrc.2021.12.069

8. Altered Mitochondrial Quality Control in Rats with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Induced by High-Fat Feeding

Author:
Federica Cioffi; Antonia Giacco; Giuseppe Petito; Rita de Matteis; Rosalba Senese; Assunta Lombardi; Pieter de Lange; Maria Moreno; Fernando Goglia; Antonia Lanni; Elena Silvestri
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
animal models; biogenesis; chronic exposure; fatty liver; high fat diet; humans; mitochondria; mitochondrial DNA; mitophagy; noninsulin-dependent diabetes mellitus; obesity; quality control; rats; reactive oxygen species; temperature
Abstract:
... Metabolic dysfunction-associated fatty liver disease (MAFLD) is defined as the presence of hepatic steatosis in addition to one of three metabolic conditions: overweight/obesity, type 2 diabetes mellitus, or metabolic dysregulation. Chronic exposure to excess dietary fatty acids may cause hepatic steatosis and metabolic disturbances. The alteration of the quality of mitochondria is one of the fact ...
DOI:
10.3390/genes13020315

9. Angiopoietin-like protein 4 promotes hyperlipidemia-induced renal injury by down-regulating the expression of ACTN4

Author:
Yue Li; Wangqiu Gong; Jing Liu; Xingxing Chen; Yanhong Suo; Huabing Yang; Xia Gao
Source:
Biochemical and biophysical research communications 2022 v.595 pp. 69-75
ISSN:
0006-291X
Subject:
albumins; blood; blood lipids; genes; high fat diet; hyperlipidemia; kidneys; lipid metabolism; proteinuria; research
Abstract:
... The molecular mechanism of in hyperlipidemia-induced renal injury has not been elucidated. Angiogenin-like protein 4 (ANGPTL4) is a key regulator of lipid metabolism. The role of ANGPTL4 hyperlipidemia-induced renal injury has not been reported. Wild type C57 mice and gene angptl4 knockout mice were fed with 60% high fat diet or normal diet respectively. The serum lipid, urinary albumin and renal ...
DOI:
10.1016/j.bbrc.2022.01.061

10. Anti-Obesity Effects of Ecklonia cava Extract in High-Fat Diet-Induced Obese Rats

Author:
Muhammad Aleem Abbas; Naila Boby; Eon-Bee Lee; Joo-Heon Hong; Seung-Chun Park
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
Ecklonia; adipose tissue; anti-obesity effects; biomarkers; dose response; epididymis; ethanol; fatty liver; food intake; high energy foods; high fat diet; liver; obesity; tissue weight
Abstract:
... Obesity is becoming a global epidemic as a result of high-calorie food intake and unhealthy lifestyles. Different marine plants, especially brown algae (Ecklonia cava), are traditionally used to treat different health-related issues. The study was carried out to investigate the anti-obesity properties of E. cava 70% ethanol extract. To evaluate the anti-obesity effect of E. cava, both in vitro and ...
DOI:
10.3390/antiox11020310

11. Anti-hyperglycemic, anti-hyperlipidemic, and anti-inflammatory effect of the drug Guggulutiktaka ghrita on high-fat diet-induced obese rats

Author:
Samreen M. Sheik; Pugazhandhi Bakthavatchalam; Revathi P. Shenoy; Basavaraj S. Hadapad; Deepak Nayak M; Monalisa Biswas; B.S. Varashree
Source:
Journal of Ayurveda and integrative medicine 2022 pp. 100583
ISSN:
0975-9476
Subject:
Ayurvedic medicine; anti-inflammatory activity; blood glucose; blood lipids; blood serum; cardiovascular diseases; drugs; glycemic effect; heart; high fat diet; histopathology; hyperglycemia; hyperlipidemia; inflammation; lipid composition; liver; vascular cell adhesion molecules
Abstract:
... Ayurveda is a holistic system of medicine and describes a vast array of herbs and herbal mixtures that are been demonstrated to possess efficacy in research investigations. Guggulutikthaka gritha (GTG) is one such drug evaluated for its role in skin and bone disease. In the current study, the hypoglycemic, hypolipidemic, and anti-inflammatory effect of the drug GTG was studied with the scope to tr ...
DOI:
10.1016/j.jaim.2022.100583

12. Anti-obesity effect of Cydonia oblonga Miller extract in high-fat diet-induced obese C57BL/6 mice

Author:
Hyun Sook Lee; Young Eun Jeon; Jae In Jung; So Mi Kim; Su Hee Hong; Jaehak Lee; Jung Soon Hwang; Myeong Oh Hwang; Kisung Kwon; Eun Ji Kim
Source:
Journal of functional foods 2022 v.89 pp. 104945
ISSN:
1756-4646
Subject:
ATP citrate synthase; Cydonia oblonga; acetyl-CoA carboxylase; adipocytes; adipogenesis; adiponectin; adipose tissue; anti-obesity agents; anti-obesity effects; beta oxidation; blood serum; carboxylic ester hydrolases; carnitine palmitoyltransferase; fatty-acid synthase; gene expression; high fat diet; insulin; leptin; lipolysis; obesity; tissue weight; triacylglycerols
Abstract:
... The present study was designed to explore whether Cydonia oblonga Miller extract (COME) had anti-obesity effects and the mechanism involved. COME reduced body weight, fat mass, adipose tissue weight, and serum levels of insulin, triglyceride, and leptin, but increased the serum levels of adiponectin and high-density lipoprotein-cholesterol in high-fat diet (HFD)-induced obese C57BL/6 mice. COME in ...
DOI:
10.1016/j.jff.2022.104945

13. Antiatherosclerotic effects of corilagin via suppression of the LOX-1/MyD88/NF-κB signaling pathway in vivo and in vitro

Author:
Bo He; Deyun Chen; Xiaochao Zhang; Renhua Yang; Yuan Yang; Peng Chen; Zhiqiang Shen
Source:
Natural medicines 2022 v.76 no.2 pp. 389-401
ISSN:
1340-3443
Subject:
Phyllanthus urinaria; aorta; atherosclerosis; blood lipids; blood serum; chemokine CCL2; colorimetry; foams; glycemic effect; high fat diet; histology; polyphenols; protein synthesis; rabbits; reverse transcriptase polymerase chain reaction; smooth muscle; transcription factor NF-kappa B
Abstract:
... Corilagin, a natural polyphenol compound isolated from Phyllanthus urinaria L., exerts various pharmacological effects, such as antihyperglycemic, antitumor, and antioxidative stress properties, but the mechanisms underlying the antiatherosclerotic effects of corilagin have not been entirely elucidated. In the present study, we investigated the antiatherosclerotic effects of corilagin using a high ...
DOI:
10.1007/s11418-021-01594-y

14. Antidiabetic Effects of Pediococcus acidilactici pA1c on HFD-Induced Mice

Author:
Miriam Cabello-Olmo; María Oneca; María José Pajares; Maddalen Jiménez; Josune Ayo; Ignacio J. Encío; Miguel Barajas; Miriam Araña
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
Pediococcus acidilactici; animal models; blood glucose; body weight changes; c-peptide; disease progression; gene expression; glucagon-like peptide 1; glucose; glucose tolerance; glucose tolerance tests; high fat diet; histology; insulin resistance; interleukin-6; intestinal microorganisms; intestines; leptin; lipid composition; noninsulin-dependent diabetes mellitus; placebos; probiotics; risk factors; villi
Abstract:
... Prediabetes (PreD), which is associated with impaired glucose tolerance and fasting blood glucose, is a potential risk factor for type 2 diabetes mellitus (T2D). Growing evidence suggests the role of the gastrointestinal microbiota in both PreD and T2D, which opens the possibility for a novel nutritional approach, based on probiotics, for improving glucose regulation and delaying disease progressi ...
DOI:
10.3390/nu14030692

15. Antidiabetic effects of multi-species probiotic and its fermented milk in mice via restoring gut microbiota and intestinal barrier

Author:
Yuxiang Gu; Xing Li; Haoran Chen; Yue Sun; Lin Yang; Ying Ma; Eric Chun Yong Chan
Source:
Food bioscience 2022 v.47 pp. 101619
ISSN:
2212-4292
Subject:
Bifidobacterium animalis subsp. lactis; Lactobacillus acidophilus; Lactobacillus rhamnosus; Streptococcus thermophilus; blood glucose; body weight changes; fermentation; glucose tolerance; high fat diet; insulin; insulin resistance; intestinal microorganisms; intestines; lipids; noninsulin-dependent diabetes mellitus; nutritional intervention; permeability; probiotics; remission; streptozotocin; tissue weight; yogurt
Abstract:
... Probiotic is a promising nutritional intervention for the prevention and alleviation of type 2 diabetes (T2DM). In this study, the remission potential of a multi-species probiotic (Lactobacillus acidophilus NCFM, Lactobacillus rhamnosus GG, Bifidobacterium lactis HN019 and Streptococcus thermophilus ST447) and its fermented yoghurt on the symptoms of high fat diet and streptozotocin induced T2DM m ...
DOI:
10.1016/j.fbio.2022.101619

16. Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity

Author:
Yi-ni Cao; Shan-shan Yue; An-yi Wang; Lu Xu; Yi-tong Hu; Xue Qiao; Tung-Ying Wu; Min Ye; Yang-Chang Wu; Rong Qi
Source:
Journal of ethnopharmacology 2022 v.292 pp. 115146
ISSN:
0378-8741
Subject:
Lentivirus; Taiwanofungus camphoratus; active ingredients; aldehyde dehydrogenase; aldehydes; blood serum; body weight; dose response; drug therapy; fatty liver; hepatocytes; high fat diet; inflammation; lipogenesis; liver; medicinal fungi; mice; mitochondria; oleic acid; oxidative stress; traditional medicine; triacylglycerols
Abstract:
... Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease, but currently has no specific medication in clinic. Antrodia cinnamomea (AC) is a medicinal fungus and it has been shown that AC can inhibit high fat diet (HFD)-induced lipid deposition in mouse livers, but the effective monomer in AC and mechanism against NAFLD remain unclear. It has been reported that aldehyde dehydrogenase 2 ...
DOI:
10.1016/j.jep.2022.115146

17. Apple polyphenol extract modulates bile acid metabolism and gut microbiota by regulating the circadian rhythms in daytime-restricted high fat diet feeding C57BL/6 male mice

Author:
Yuan Cui; Yan Yin; Shilan Li; Zhengli Wu; Yisha Xie; Qingfan Qian; Hao Yang; Xinli Li
Source:
Food & function 2022 v.13 no.5 pp. 2805-2822
ISSN:
2042-650X
Subject:
apples; bile acids; body weight; circadian clocks; health status; high fat diet; homeostasis; ileum; intestinal microorganisms; males; metabolism; polyphenols; probiotics
Abstract:
... The homeostasis of circadian clock linked to bile acid (BA) metabolism and gut microbiota has profound benefits in maintaining the health status of the host. The aim of this study was to investigate the prevention and regulation of apple polyphenol extract (APE) on BA metabolism and gut microbiota by means of modulation of circadian rhythms in mice. Eighty male C57BL/6 mice were randomized into fo ...
DOI:
10.1039/d1fo04116a

18. Astilbin from Smilax glabra Roxb. alleviates high-fat diet-induced metabolic dysfunction

Author:
Tingwei Wang; Yongli Ye; Jian Ji; Shuang Zhang; Xingxing Yang; Jiayuan Xu; Jia-Sheng Wang; Zhiyuan Chen; Bangen Xia; Hongfang Shen; Ruowei Xia; Wenqin Shi; Xiulan Sun
Source:
Food & function 2022 v.13 no.9 pp. 5023-5036
ISSN:
2042-650X
Subject:
Coriobacteriaceae; Lachnospiraceae; Ruminococcaceae; Smilax glabra; adipocytes; adipogenesis; anti-inflammatory activity; carbohydrates; droplets; dysbiosis; endotoxemia; glutamic acid; hepatoprotective effect; high fat diet; inflammation; insulin resistance; intestinal microorganisms; intestines; lipid metabolism; multiomics; obesity; prebiotics; public health; rhizomes; short chain fatty acids; triacylglycerols; xanthine
Abstract:
... Overweight, obesity, and related diseases are currently the major public health problems worldwide. Astilbin, extracted from the rhizome of Smilax glabra Roxb., is known to have significant anti-inflammatory activity and hepatoprotective effect. Studies have shown that it can inhibit adipogenesis in adipocytes in vitro; however, the intervention benefits of astilbin against obesity and related dis ...
DOI:
10.1039/d2fo00060a

19. Beneficial effects of Ilex paraguariensis in the prevention of obesity‐associated metabolic disorders in mice

Author:
Helber da Maia Valença; Cyntia Pecli e Silva; Lycia de Brito Gitirana; Samuel Santos Valença; Manuella Lanzetti
Source:
Phytotherapy research 2022 v.36 no.2 pp. 1032-1042
ISSN:
0951-418X
Subject:
Ilex paraguariensis; adipocytes; adipose tissue; antioxidant activity; biomarkers; blood; dimethyl fumarate; fatty liver; glucose; heme oxygenase (biliverdin-producing); high density lipoprotein; high fat diet; histology; hypertrophy; inflammation; leptin; liver; obesity; oxidative stress; phytotherapy; quinones; research; resistin; superoxide dismutase
Abstract:
... Obesity is a chronic condition involving inflammation and oxidative stress that commonly predisposes affected individuals to develop metabolic disorders. We hypothesize that Ilex paraguariensis (IP) can modulate oxidative stress and inflammation underpinning metabolic disorders caused by obesity. C57BL/6 mice were fed a high‐fat diet (HFD group) for 12 weeks. Concomitantly, some mice were treated ...
DOI:
10.1002/ptr.7377

20. Beneficial effects of eicosapentaenoic acid on the metabolic profile of obese female mice entails upregulation of HEPEs and increased abundance of enteric Akkermansia muciniphila

Author:
Anandita Pal; Shan Sun; Michael Armstrong; Jonathan Manke; Nicole Reisdorph; Victoria R. Adams; Arion Kennedy; Yujiao Zu; Naima Moustaid-Moussa; Ian Carroll; Saame Raza Shaikh
Source:
Biochimica et biophysica acta 2022 v.1867 no.1 pp. 159059
ISSN:
1388-1981
Subject:
RNA; biosynthesis; cell culture; cell differentiation; eicosapentaenoic acid; females; genes; glucose; high fat diet; homeostasis; insulin; intestinal microorganisms; intestines; males; mass spectrometry; mice; risk
Abstract:
... Eicosapentaenoic acid (EPA) ethyl esters are of interest given their clinical approval for lowering circulating triglycerides and cardiometabolic disease risk. EPA ethyl esters prevent metabolic complications driven by a high fat diet in male mice; however, their impact on female mice is less studied. Herein, we first investigated how EPA influences the metabolic profile of female C57BL/6J mice co ...
DOI:
10.1016/j.bbalip.2021.159059

21. Bentong ginger oleoresin mitigates liver injury and modulates gut microbiota in mouse with nonalcoholic fatty liver disease induced by high‐fat diet

Author:
Kunli Wang; Bei Li; Rao Fu; Zefang Jiang; Xin Wen; Yuanying Ni
Source:
Journal of food science 2022 v.87 no.3 pp. 1268-1281
ISSN:
0022-1147
Subject:
blood serum; cholesterol; cytokines; dietary supplements; fatty liver; food composition; functional foods; ginger; high fat diet; intestinal microorganisms; lipid metabolism; liver; mice; obesity; oleoresins; protective effect
Abstract:
... The present study aimed to examine the protective effect of Bentong ginger oleoresin (BGO) on the occurrence of nonalcoholic fatty liver disease (NAFLD) and its underlying mechanism. In the present study, 14‐week BGO treatment reduced the high‐fat diet (HFD)‐induced obesity. The serum total cholesterol (TC) was reduced from 4.76 ± 0.30 to 3.542 ± 0.49 mmol/L and fatty liver score decreased to the ...
DOI:
10.1111/1750-3841.16076

22. Biochemical characterization of high fat diet fed and low dose streptozotocin induced diabetic Wistar rat model

Author:
Akurange Sujeevi D. Wickramasinghe; Anoja P. Attanayake; Pabasara Kalansuriya
Source:
Journal of pharmacological and toxicological methods 2022 v.113 pp. 107144
ISSN:
1056-8719
Subject:
blood serum; dose response; glucose; glycohemoglobin; high fat diet; insulin; insulin resistance; lipid composition; low density lipoprotein cholesterol; noninsulin-dependent diabetes mellitus; risk; saturated fats; streptozotocin; toxicology; very low density lipoprotein
Abstract:
... The development of a stable disease model with an adequate biochemical profile is crucial for the preclinical investigation of new antidiabetic agents. This study aimed at optimization and characterization of high fat diet (HFD) fed streptozotocin (STZ) induced type 2 diabetes mellitus (type 2 DM) Wistar rat model. Wistar rats fed with HFD for four weeks received STZ (30, 40, and 50 mg/kg, intrape ...
DOI:
10.1016/j.vascn.2021.107144

23. Chicory polysaccharides alleviate high-fat diet-induced non-alcoholic fatty liver disease via alteration of lipid metabolism- and inflammation-related gene expression

Author:
Shengjie Li; Yulong Wu; Haitao Jiang; Feng Zhou; Ailing Ben; Renlei Wang; Chun Hua
Source:
Food science and human wellness 2022 v.11 no.4 pp. 954-964
ISSN:
2213-4530
Subject:
chicory; fatty acids; fatty liver; food science; gene expression; high fat diet; humans; hyperlipidemia; inflammation; lipogenesis; liver; metabolomics; polysaccharides; sequence analysis; therapeutics; transcriptomics
Abstract:
... Administration of chicory polysaccharides (CP) can modify lipid metabolism, improve dyslipidemia, and reduce liver inflammation, all of which may help alleviate non-alcoholic fatty liver disease (NAFLD). However, the underlying mechanisms remain unclear. This study aimed to gain further understanding of the potential molecular mechanisms that mediate the protective effects of CP against NAFLD via ...
DOI:
10.1016/j.fshw.2022.03.025

24. Chinese Torreya grandis cv. Merrillii seed oil affects obesity through accumulation of sciadonic acid and altering the composition of gut microbiota

Author:
Huan Wang; Ye Li; Rui Wang; Huaifei Ji; Chenyang Lu; Xiurong Su
Source:
Food science and human wellness 2022 v.11 no.1 pp. 58-67
ISSN:
2213-4530
Subject:
Bifidobacterium; Lactobacillus; Torreya grandis; fatty acid composition; high fat diet; humans; hyperlipidemia; intestinal microorganisms; lipid metabolism; liver; low density lipoprotein cholesterol; nutritive value; obesity; seed oils; short chain fatty acids; China
Abstract:
... Torreya grandis cv. Merrillii (Taxace, Torreya) is mainly distributed across the hilly areas of subtropical China and is well known for its nutritional value. In this study, the ameliorative effects of T. grandis seed oil on lipid metabolism were investigated, and the underlying mechanism was explored from the perspective of gut microbiota. Mice experiments showed that the rate of body mass gain i ...
DOI:
10.1016/j.fshw.2021.07.007

25. Chitosan oligosaccharide mitigates kidney injury in prediabetic rats by improving intestinal barrier and renal autophagy

Author:
Prempree Sutthasupha; Sasivimon Promsan; Laongdao Thongnak; Nattavadee Pengrattanachot; Nichakorn Phengpol; Onanong Jaruan; Krit Jaikumkao; Chatchai Muanprasat; Rath Pichyangkura; Varanuj Chatsudthipong; Anusorn Lungkaphin
Source:
Carbohydrate polymers 2022 v.288 pp. 119405
ISSN:
0144-8617
Subject:
absorption; anti-inflammatory activity; autophagy; calcium receptors; chitosan; excretion; glucose; high fat diet; inflammation; intestines; kidneys; lipids; metabolic syndrome; models; noninsulin-dependent diabetes mellitus; obesity; oligosaccharides; risk
Abstract:
... Consumption of a high-fat diet (HFD) not only increases the risk of metabolic syndrome but also initiates kidney injury. Lipid accumulation-induced systemic low-grade inflammation is an upstream mechanism of kidney injury associated with prediabetes. Chitosan oligosaccharide (COS) provides potent anti-obesity effects through several mechanisms including fecal lipid excretion. In this study, we inv ...
DOI:
10.1016/j.carbpol.2022.119405

26. Cholic acid supplementation accelerates the progression of nonalcoholic fatty liver disease to the procarcinogenic state in mice fed a high-fat and high-cholesterol diet

Author:
Hee Jeong Chun; Yeon Joo Shim; Young Hye Kwon
Source:
Journal of nutritional biochemistry 2022 v.100 pp. 108869
ISSN:
0955-2863
Subject:
amino acid metabolism; apoptosis; biosynthesis; carcinogenicity; cholesterol; cholic acid; diethylnitrosamine; drugs; energy; fatty liver; gene expression; gene expression regulation; hepatoma; high fat diet; histology; inflammation; microarray technology; mitochondria; necrosis; oxidative phosphorylation; steroid metabolism; triacylglycerols
Abstract:
... Nonalcoholic fatty liver disease (NAFLD) is one of the major causes of hepatocellular carcinoma (HCC). Although the intracellular cholesterol accumulation has been demonstrated to regulate the gene expression responsible for steatohepatitis, the role played by cholesterol in the development of NAFLD-associated HCC has not been fully elucidated. In this study, using microarray analysis, we investig ...
DOI:
10.1016/j.jnutbio.2021.108869

27. Co-delivery of EGCG and lycopene via a pickering double emulsion induced synergistic hypolipidemic effect

Author:
Qun Wang; Ling Wang; Abdullah; Wenni Tian; Mingyue Song; Yong Cao; Jie Xiao
Source:
Food & function 2022 v.13 no.6 pp. 3419-3430
ISSN:
2042-650X
Subject:
absorption; animal models; bioavailability; blood lipids; blood serum; cholesterol; droplets; emulsions; epigallocatechin gallate; fatty liver; food industry; health promotion; high fat diet; hydrophilicity; lipemic effect; lipid composition; lipophilicity; liver; lycopene
Abstract:
... The concept of “synergy” and its applications has rapidly increased in the food industry as a practical strategy to preserve and improve health-promoting effects of the functional ingredients. In this study, hydrophilic epigallocatechin-3-gallate (EGCG) and lipophilic lycopene (LYC) were loaded separately (EGCG loaded PDE (PE), and LYC loaded PDE (PL), and also co-delivered (PEL) within a pickerin ...
DOI:
10.1039/d2fo00169a

28. Colchicine prevents ventricular arrhythmias vulnerability in diet-induced obesity rats

Author:
Zhiyang Lv; Xiaodi Chen; Ping Chen; Qianyuan Li; Zhuli Guo; Qing Lu; Shifang Ding
Source:
Biochemical and biophysical research communications 2022 v.610 pp. 127-132
ISSN:
0006-291X
Subject:
Western blotting; calcium-calmodulin-dependent protein kinase; colchicine; electrophysiology; fibrosis; high fat diet; histology; males; obesity; research
Abstract:
... This study aimed to assess the role of colchicine in ventricular arrhythmias (VAs) induced by high fat diet (HFD)-fed rats. Male rats were divided into four groups: CTL, normal diet plus saline; CTC, normal diet plus colchicine; HFD, HFD plus saline; HFC: HFD plus colchicine. Metabolic parameters, ECG parameters, ventricular electrophysiological parameters, ventricular histology, Western blot and ...
DOI:
10.1016/j.bbrc.2022.03.114

29. Combination Effects of Metformin and a Mixture of Lemon Balm and Dandelion on High-Fat Diet-Induced Metabolic Alterations in Mice

Author:
Jae Young Choi; Tae-Woo Jang; Phil Hyun Song; Seong Hoon Choi; Sae-Kwang Ku; Chang-Hyun Song
Source:
Antioxidants 2022 v.11 no.3 pp. -
ISSN:
2076-3921
Subject:
AMP-activated protein kinase; Melissa officinalis; Taraxacum; alanine transaminase; antioxidants; blood; body fat; creatinine; fatty liver; glucose; high fat diet; histopathology; hypertrophy; insulin; insulin resistance; lipid metabolism; metformin; mice; noninsulin-dependent diabetes mellitus; oral administration; triacylglycerols; urea nitrogen; weight gain
Abstract:
... Metformin, the first-line drug for type 2 diabetes mellitus (T2DM), has additional effects on improvements of nonalcoholic fatty liver disease (NAFLD); however, there are no treatments for both T2DM and NAFLD. Previous studies have shown hepatoprotective effects of a mixture of lemon balm and dandelion (LD) through its antioxidant and anti-steatosis properties. Thus, combination effects of metform ...
DOI:
10.3390/antiox11030580

30. Combined Phyllostachys pubescens and Scutellaria baicalensis Prevent High-Fat Diet-Induced Obesity via Upregulating Thermogenesis and Energy Expenditure by UCP1 in Male C57BL/6J Mice

Author:
Yoon-Young Sung; Seung-Hyung Kim; Dong-Seon Kim
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
Phyllostachys edulis; Scutellaria baicalensis; adipocytes; adiponectin; blood serum; energy expenditure; fatty-acid synthase; free fatty acids; gene expression; glucose; heat production; high fat diet; insulin; lactate dehydrogenase; leaves; leptin; lipid metabolism; liver; low density lipoprotein cholesterol; males; muscles; obesity; protein synthesis; triacylglycerols; white adipose tissue
Abstract:
... This study examined the anti-obesity effects of a Phyllostachys pubescens (leaf) and Scutellaria baicalensis root mixture (BS21), and its underlying mechanisms of action, in high-fat diet (HFD)-induced obese mice. Mice were fed a HFD with BS21 (100, 200, or 400 mg/kg) for 9 weeks. BS21 reduced body weight, white adipose tissue (WAT) and liver weights, liver lipid accumulation, and adipocyte size. ...
DOI:
10.3390/nu14030446

31. Comparative proteomic analysis reveals the effects of different fatty acid forms on high-fat diet mice

Author:
Jiaping Pan; Huan Wang; Ye Li; Chenyang Lu
Source:
Food science and human wellness 2022 v.11 no.2 pp. 316-322
ISSN:
2213-4530
Subject:
body weight changes; fish oils; food science; gene expression regulation; high density lipoprotein cholesterol; high fat diet; humans; krill; lipogenesis; liver; low density lipoprotein cholesterol; oxidation; phospholipids; proteomics
Abstract:
... Long-chain omega-3 polyunsaturated fatty acids (LC-PUFAs), known for having many health benefits, are usually present in three forms: triglycerides (TG), ethyl esters (EE), and phospholipid (PL). In this study, the effects of these three LC-PUFAs forms (fish oil for TG and EE, krill oil for PL) on the obese mice were compared, and the proteomic changes that focused on lipid metabolism were evaluat ...
DOI:
10.1016/j.fshw.2021.11.005

32. Comparative study on molecular mechanism of diabetic myopathy in two different types of streptozotocin-induced diabetic models

Author:
Tolulope Peter Saliu; Thanutchaporn Kumrungsee; Kenshu Miyata; Hikaru Tominaga; Nao Yazawa; Kotaro Hashimoto; Mion Kamesawa; Noriyuki Yanaka
Source:
Life sciences 2022 v.288 pp. 120183
ISSN:
0024-3205
Subject:
blood; blood glucose; collagen; comparative study; cytotoxicity; gene expression; glucocorticoids; high fat diet; histology; humans; immunochemistry; inflammation; mitochondria; muscular diseases; streptozotocin
Abstract:
... Streptozotocin (STZ)-induced diabetic animal models have been widely used to study diabetic myopathy; however, non-specific cytotoxic effects of high-dose STZ have been discussed. The purpose of this study was to compare diabetic myopathy in a high-STZ model with another well-established STZ model with reduced cytotoxicity (high-fat diet (HFD) and low-dose STZ) and to identify mechanistic insights ...
DOI:
10.1016/j.lfs.2021.120183

33. Concentration-dependent change in hypothalamic neuronal transcriptome by the dietary fatty acids: oleic and palmitic acids

Author:
Fabiola Pacheco Valencia; Amanda F. Marino; Christos Noutsos; Kinning Poon
Source:
Journal of nutritional biochemistry 2022 pp. 109033
ISSN:
0955-2863
Subject:
acid treatment; apoptosis; cell viability; gene ontology; genes; high fat diet; integrins; neurogenesis; neurons; oleic acid; palmitic acid; progeny; protein synthesis; transcription (genetics); transcriptome
Abstract:
... Prenatal high-fat diet exposure increases hypothalamic neurogenesis events in embryos and programs offspring to be obesity-prone. The molecular mechanism involved in these dietary effects of neurogenesis are unknown. This study investigated the effects of oleic and palmitic acids, which are abundant in a high-fat diet, on the hypothalamic neuronal transcriptome and how these changes impact neuroge ...
DOI:
10.1016/j.jnutbio.2022.109033

34. Cooked common bean flour, but not its protein hydrolysate, has the potential to improve gut microbiota composition and function in BALB/c mice fed a high-fat diet added with 6-propyl-2-thiouracil

Author:
Mariana Juste Contin Gomes; Juliana Soares da Silva; Natalia Elizabeth Galdino Alves; Andressa de Assis; Elvira Gonzalez de Mejía; Hilário Cuquetto Mantovani; Hércia Stampini Duarte Martino
Source:
Journal of nutritional biochemistry 2022 pp. 109022
ISSN:
0955-2863
Subject:
Bacteroidetes; Firmicutes; adults; bean flour; beans; cecum; chemical composition; dietary fiber; feces; genes; high fat diet; intestinal microorganisms; propylthiouracil; protein hydrolysates; species diversity; thyroid hormones
Abstract:
... Common bean has the potential to improve gut microbiota function due to its chemical composition and content of dietary fiber. This study evaluated the effect of Cooked Common Bean (CCB) flour and its protein hydrolysate as part of a high-fat diet (HFD) added with 6-propyl-2-thiouracil (PTU) (10 mg/kg/day), an inhibitor of thyroid hormone synthesis, on gut health of BALB/c mice. Forty-eight adult ...
DOI:
10.1016/j.jnutbio.2022.109022

35. Copper-catalyzed dicarbonyl stress in NAFLD mice: protective effects of Oleuropein treatment on liver damage

Author:
Silvano Junior Santini; Giovanni Tarantino; Antonella Iezzi; Anna Alisi; Clara Balsano
Source:
Nutrition & metabolism 2022 v.19 no.1 pp. 9
ISSN:
1743-7075
Subject:
chelating agents; fatty liver; females; high fat diet; homeostasis; liver; males; metabolic syndrome; metabolism; oleuropein; pathogenesis
Abstract:
... BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) or more appropriately, metabolic associated fatty liver disease (MAFLD), is the hepatic manifestation of metabolic syndrome. An imbalance of copper homeostasis has been described in the progression of NAFLD/MAFLD toward NASH/MASH. We were interested in understanding whether the chelating activity of Oleuropein (Ole) was able to improve the coppe ...
DOI:
10.1186/s12986-022-00641-z

36. Di-(2-ethylhexyl) Phthalate Substitutes Accelerate Human Adipogenesis through PPARγ Activation and cause Oxidative Stress and Impaired Metabolic Homeostasis in Mature Adipocytes

Author:
Alexandra Schaffert; Isabel Karkossa; Elke Ueberham; Rita Schlichting; Katharina Walter; Josi Arnold; Matthias Blüher; John T. Heiker; Jörg Lehmann; Martin Wabitsch; Beate I. Escher; Martin von Bergen; Kristin Schubert
Source:
Environment international 2022 pp. 107279
ISSN:
0160-4120
Subject:
adipocytes; adipogenesis; adipose tissue; agonists; environment; high fat diet; homeostasis; humans; insulin resistance; leptin; lipids; metabolic syndrome; metabolites; obesity; oxidative stress; pandemic; peroxisome proliferator-activated receptor gamma; phthalates; plasticizers; proteomics; secretion
Abstract:
... The obesity pandemic is presumed to be accelerated by endocrine disruptors such as phthalate-plasticizers, which interfere with adipose tissue function. With the restriction of the plasticizer di-(2-ethylhexyl)-phthalate (DEHP), the search for safe substitutes gained importance. Focusing on the master regulator of adipogenesis and adipose tissue functionality, the peroxisome proliferator-activated ...
DOI:
10.1016/j.envint.2022.107279

37. Diet dependent impact of benzoate on diabetes and obesity in mice

Author:
Francois Brial; Fumihiko Matsuda; Dominique Gauguier
Source:
Biochimie 2022 v.194 pp. 35-42
ISSN:
0300-9084
Subject:
adiposity; collagen; diabetes; genes; glucose; high fat diet; homeostasis; inflammation; insulin secretion; intestinal microorganisms; liver; metabolites; obesity; risk reduction; therapeutics; triacylglycerols
Abstract:
... The gut microbiota contributes to mammalian host biology by supplying metabolites from nutrients and pro-inflammatory molecules. We have recently shown that urinary hippurate is associated with reduced risk of obesity, increased gut microbiome diversity and gene richness, and functional modules for microbial production of its precursor benzoate. Obese mice infused with hippurate exhibit profound a ...
DOI:
10.1016/j.biochi.2021.12.010

38. Dietary Alaska Pollack Protein Induces Acute and Sustainable Skeletal Muscle Hypertrophy in Rats

Author:
Kenji Uchida; Mina Fujitani; Takafumi Mizushige; Fuminori Kawabata; Kohsuke Hayamizu; Keisuke Uozumi; Yuma Hara; Mariko Sawai; Ryota Uehigashi; Shinji Okada; Naoko Goto-Inoue; Mizuki Morisasa; Taro Kishida
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
Gadus chalcogrammus; blood serum; casein; crude protein; dietary fat; gene expression; high fat diet; hypertrophy; lipid content; males; muscle fibers; myosin; protein sources; skeletal muscle
Abstract:
... Our previous studies suggested that Alaska pollack protein (APP) intake increases skeletal muscle mass and that it may cause a slow-to-fast shift in muscle fiber type in rats fed a high-fat diet after 56 days of feeding. In this study, we explored whether dietary APP induces acute and sustainable skeletal muscle hypertrophy in rats fed a normal-fat diet. Male 5-week-old Sprague–Dawley rats were di ...
DOI:
10.3390/nu14030547

39. Dietary fucoidan from a brown marine algae (Ecklonia cava) attenuates lipid accumulation in differentiated 3T3-L1 cells and alleviates high-fat diet-induced obesity in mice

Author:
Hyo-Geun Lee; Thilina U. Jayawardena; Kyung-Mo Song; Yun-Sang Choi; You-Jin Jeon; Min-Cheol Kang
Source:
Food and chemical toxicology 2022 v.162 pp. 112862
ISSN:
0278-6915
Subject:
Ecklonia; adipocytes; blood lipids; body weight changes; dietary supplements; energy expenditure; fucoidan; high fat diet; histology; hydrolysates; ingredients; lipid content; lipids; liver; obesity; oral administration; sulfates; toxicology; white adipose tissue
Abstract:
... Fucoidan from marine algae is used as a functional ingredient in the food. Here, we purified fucoidan fractions from a crude polysaccharide obtained after the crude polysaccharide of celluclast-assisted hydrolysate from Ecklonia cava (ECC). We evaluated the effect of ECC on lipid accumulation in differentiated 3T3-L1 adipocytes and investigated its anti-obesity effects in vivo in high-fat diet (HF ...
DOI:
10.1016/j.fct.2022.112862

40. Dietary induction of obesity and insulin resistance is associated with changes in Fgf21 DNA methylation in liver of mice

Author:
Cathleen Geißler; Christin Krause; Anne-Marie Neumann; Jan H. Britsemmer; Natalie Taege; Martina Grohs; Meike Kaehler; Ingolf Cascorbi; Alfor G. Lewis; Randy J. Seeley; Henrik Oster; Henriette Kirchner
Source:
Journal of nutritional biochemistry 2022 v.100 pp. 108907
ISSN:
0955-2863
Subject:
DNA methylation; fatty acid metabolism; fibroblast growth factors; glucose; glucose tolerance; high fat diet; homeostasis; insulin resistance; lifestyle; liver; males; metformin; obesity; weight loss
Abstract:
... DNA methylation is dynamically regulated in metabolic diseases, but it remains unclear whether the changes are causal or consequential. Therefore, we used a longitudinal approach to refine the onset of metabolic and DNA methylation changes at high temporal resolution. Male C57BL/6N mice were fed with 60 % high-fat diet (HFD) for up to 12 weeks and metabolically characterized weekly. Liver was coll ...
DOI:
10.1016/j.jnutbio.2021.108907

41. Dietary rhamnogalacturonan-Ⅰ rich extracts of molokhia ameliorate high fat diet-induced obesity and gut dysbiosis

Author:
Hye-Bin Lee; Mi-Jin Oh; Moon Ho Do; Yoonsook Kim; Inwook Choi; Young-Soo Kim; Ho-Young Park
Source:
Journal of nutritional biochemistry 2022 v.103 pp. 108954
ISSN:
0955-2863
Subject:
Bacteroidetes; Corchorus olitorius; Firmicutes; adipocytes; blood serum; digestive system; dysbiosis; high fat diet; intestinal microorganisms; leaves; low density lipoprotein cholesterol; mortality; mucilages; obesity; permeability; tight junctions; triacylglycerols; water solubility; Africa; Asia
Abstract:
... Obesity is a global health issue associated with increased prevalence of disease and mortality. Molokhia (Corchorus olitorius L.) leaves, used as vegetables in Asia and Africa, comprise abundant water-soluble mucilage polysaccharides. The present study aimed to evaluate the effects of molokhia leaf polysaccharide fraction (MPF) on high-fat diet (HFD)-induced obesity and gut dysbiosis in mice. A si ...
DOI:
10.1016/j.jnutbio.2022.108954

42. ELAV-like RNA binding protein 1 regulates osteogenesis in diabetic osteoporosis: Involvement of divalent metal transporter 1

Author:
Yuanfei Ren; Maowei Yang; Xindong Wang; Buxuan Xu; Zerong Xu; Bo Su
Source:
Molecular and cellular endocrinology 2022 v.546 pp. 111559
ISSN:
0303-7207
Subject:
RNA; ammonium; bioinformatics; bone density; bone formation; citrates; diabetes mellitus; divalent metals; endocrinology; glucose; high fat diet; intraperitoneal injection; iron overload; mice; mineralization; osteoblasts; osteoporosis; oxidative stress; pathogenesis; prediction; streptozotocin; therapeutics; viability
Abstract:
... Diabetic osteoporosis (DOP) is a complication of diabetes mellitus (DM) and occurs due to alterations in bone metabolism under hyperglycemic condition. ELAV-like RNA binding protein 1 (ELAVL1) is abnormally up-regulated in diabetes-related diseases. Bioinformatics prediction indicates that divalent metal transporter 1 (DMT1) is a potential target of ELAVL1. To explore the role of ELAVL1 and the in ...
DOI:
10.1016/j.mce.2022.111559

43. Effect of Type 2 Diabetes and Impaired Glucose Tolerance on Digestive Enzymes and Glucose Absorption in the Small Intestine of Young Rats

Author:
Lyudmila V. Gromova; Alexandr S. Polozov; Elizaveta V. Savochkina; Anna S. Alekseeva; Yulia V. Dmitrieva; Oleg V. Kornyushin; Andrey A. Gruzdkov
Source:
Nutrients 2022 v.14 no.2 pp. -
ISSN:
2072-6643
Subject:
absorption; alkaline phosphatase; alpha-glucosidase; colon; enterocytes; glucose; glucose tolerance; high fat diet; jejunum; microvilli; noninsulin-dependent diabetes mellitus; streptozotocin
Abstract:
... The reactions of intestinal functional parameters to type 2 diabetes at a young age remain unclear. The study aimed to assess changes in the activity of intestinal enzymes, glucose absorption, transporter content (SGLT1, GLUT2) and intestinal structure in young Wistar rats with type 2 diabetes (T2D) and impaired glucose tolerance (IGT). To induce these conditions in the T2D (n = 4) and IGT (n = 6) ...
DOI:
10.3390/nu14020385

44. Effectiveness of a new rutin Cu(II) complex in the prevention of lipid peroxidation and hepatotoxicity in hypercholesterolemic rats

Author:
Daniel A. F. de Oliveira; Susana N. Diniz; Regina M. S. Pereira; Ivair D. Gonçalves; André L. Rennó; Renata Gorjão; Eduardo G. Vieira; Ana M. da C. Ferreira; Cristina E. Okuyama
Source:
Journal of food biochemistry 2022 v.46 no.3 pp. e13999
ISSN:
0145-8884
Subject:
antioxidants; blood serum; cholesterol; copper; dietary supplements; hepatotoxicity; high fat diet; histology; hypercholesterolemia; inflammation; lipid peroxidation; liver; malondialdehyde; neutrophils; rutin; simvastatin; spectroscopy
Abstract:
... A new rutin copper(II) complex (R‐Cu2) was prepared and characterized by spectroscopic methods and elemental analysis. The effects of rutin and R‐Cu2 were evaluated on the prevention of hypercholesterolemia in animals feed with high‐cholesterol diet (HCD) for 8 weeks. The animals (n = 5) were neither fed with HCD nor treated (control group), or were treated with vehicle, 10 mg/kg simvastatin, ruti ...
DOI:
10.1111/jfbc.13999

45. Effects of Ovariectomy and Exercise Training on Mineral Status in a High-Fat Diet-Induced Obesity Rat Model

Author:
Vlasta Masanova; Zora Krivosikova; Monika Ursinyova; Iveta Uhnakova; Anton Kebis; Patricia Kramarova; Ladislava Wsolova; Martin Gajdos
Source:
Biological trace element research 2022 v.200 no.2 pp. 624-634
ISSN:
0163-4984
Subject:
animal models; antioxidants; bone health; bone mineralization; estrogens; exercise; females; femur; high fat diet; obesity; osteoporosis; ovariectomy; pathophysiology; protective effect; public health; research
Abstract:
... Osteoporosis is a growing public health issue for an aging society. Previous studies have found both beneficial and detrimental effects of obesity on bone health. The purpose of this study was to investigate the impact of estrogen deficiency and physical activity on bone and blood concentrations of macrominerals (Ca, P, and Mg) and microminerals (Zn, Se, Cu, and Fe) in a high-fat diet-induced obes ...
DOI:
10.1007/s12011-021-02655-9

46. Effects of Siraitia grosvenorii extracts on high fat diet-induced obese mice：a comparison with artificial sweetener aspartame

Author:
Ke Lü; Xiaowan Song; Peng Zhang; Wei Zhao; Ning Zhang; Fan Yang; Wenqiang Guan; Jianfu Liu; He Huang; Chi-Tang Ho; Rong Di; Hui Zhao
Source:
Food science and human wellness 2022 v.11 no.4 pp. 865-873
ISSN:
2213-4530
Subject:
Siraitia grosvenorii; aspartame; body weight changes; chemoattractants; food science; fruits; high fat diet; humans; inflammation; insulin resistance; intestinal microorganisms; leptin; macrophages; necrosis; neoplasms; obesity; risk
Abstract:
... Long-term artificial sweetener intake is linked to increased risk of obesity. In the present study, supplement of natural sweetener from Siraitia grosvenorii (SG) (or Momordica grosvenorii) fruit, compared with the artificial sweetener aspartame (ASM), was evaluated for anti-obesity effects on mice fed with high fat diet (HFD). We found that, in contrary to ASM, SG extracts prevented body weight g ...
DOI:
10.1016/j.fshw.2022.03.009

47. Effects of the Water Extract of Fermented Rice Bran on Liver Damage and Intestinal Injury in Aged Rats with High-Fat Diet Feeding

Author:
Ting-Yu Chen; Ya-Ling Chen; Wan-Chun Chiu; Chiu-Li Yeh; Yu-Tang Tung; Hitoshi Shirakawa; Wei-Tzu Liao; Suh-Ching Yang
Source:
Plants 2022 v.11 no.5 pp. -
ISSN:
2223-7747
Subject:
Aspergillus kawachii; Lachnospiraceae; Lactobacillaceae; acclimation; antioxidant activity; fatty liver; fermentation; high fat diet; inflammation; interleukins; intestines; leptin; liver; males; rice bran
Abstract:
... The purpose of this study was to investigate the protective effects of the water extract of fermented rice bran (FRB) on liver damage and intestinal injury in old rats fed a high-fat (HF) diet. Rice bran (RB) was fermented with Aspergillus kawachii, and FRB was produced based on a previous study. Male Sprague Dawley rats at 36 weeks of age were allowed free access to a standard rodent diet and wat ...
DOI:
10.3390/plants11050607

48. Endothelial group IVA phospholipase A2 promotes hepatic fibrosis with sinusoidal capillarization in the early stage of non-alcoholic steatohepatitis in mice

Author:
Eri Kawashita; Takeyoshi Ozaki; Keiichi Ishihara; Chihiro Kashiwada; Satoshi Akiba
Source:
Life sciences 2022 v.294 pp. 120355
ISSN:
0024-3205
Subject:
actin; arachidonic acid; collagen; endothelial cells; fatty liver; fibrosis; high fat diet; immunoblotting; isozymes; liver; liver cirrhosis; methionine; models; muscles; phospholipase A2; phospholipases; therapeutics
Abstract:
... Non-alcoholic steatohepatitis (NASH) is characterized by steatosis, inflammatory responses and fibrosis. Our previous studies provided evidence that group IVA phospholipase A₂ (IVA-PLA₂), a key PLA₂ isozyme in the arachidonic acid cascade, is involved in the development of NASH. However, which types of cells are critical for the IVA-PLA₂-dependent onset and progression of NASH is unclear. We eluci ...
DOI:
10.1016/j.lfs.2022.120355

49. Epigallocatechin-3-gallate + L-theanine/β-cyclodextrin inclusion complexes enhance epigallocatechin-3-gallate bioavailability and its lipid-lowering and weight loss effects

Author:
Baogui Liu; Zhiyin Chen; Yangling Zhang; Enshuo Liu; Shuming Han; Zhihua Gong; Wenjun Xiao
Source:
Journal of functional foods 2022 v.90 pp. 104998
ISSN:
1756-4646
Subject:
antioxidant activity; bioavailability; digestion; epigallocatechin gallate; freeze drying; green tea; high fat diet; hydrogen; intestinal microorganisms; lipids; weight loss
Abstract:
... Epigallocatechin-3-gallate (EGCG) and L-theanine (LTA), which are active ingredients in green tea, can inhibit fat accumulation; however, EGCG bioavailability is <5%. Here, we aimed to improve EGCG bioavailability and efficacy by preparing EGCG + LTA/β-cyclodextrin (βCD) inclusion complexes by freeze-drying EGCG + LTA at their mass ratio (5:1) in green tea. Physicochemical characterisation reveale ...
DOI:
10.1016/j.jff.2022.104998

50. Flavonoid constituents of Amomum tsao-ko Crevost et Lemarie and their antioxidant and antidiabetic effects in diabetic rats – in vitro and in vivo studies

Author:
Xiao-Feng Zhang; Yu-Jun Tang; Xiao-Xian Guan; Xin Lu; Jiao Li; Xiao-Li Chen; Jin-Lan Deng; Jian-Ming Fan
Source:
Food & function 2022 v.13 no.1 pp. 437-450
ISSN:
2042-650X
Subject:
Amomum tsao-ko; Oriental traditional medicine; alpha-amylase; antioxidant activity; antioxidants; blood glucose; flavonoids; freeze drying; functional foods; glucose tolerance; glycemic effect; high fat diet; histopathology; insulin; malondialdehyde; methanol; noninsulin-dependent diabetes mellitus; pancreas; spices; streptozotocin; superoxide dismutase
Abstract:
... Amomum tsao-ko Crevost et Lemarie (A. tsao-ko) is a well-known dietary spice and traditional Chinese medicine. This study aimed to identify the flavonoids in A. tsao-ko and evaluate their antioxidant and antidiabetic activities in in vitro and in vivo studies. A. tsao-ko methanol extracts possessed a high flavonoid content (1.21 mg QE per g DW) and a total of 29 flavonoids were identified by emplo ...
DOI:
10.1039/d1fo02974f

51. Flaxseed‐derived peptide, IPPF, inhibits intestinal cholesterol absorption in Caco‐2 cells and hepatic cholesterol synthesis in HepG2 cells

Author:
Xiaolan Bao; Xingyu Yuan; Xuexin Li; Xiaojing Liu
Source:
Journal of food biochemistry 2022 v.46 no.1 pp. e14031
ISSN:
0145-8884
Subject:
absorption; atherosclerosis; blood serum; byproducts; cholesterol; diet therapy; high fat diet; hypercholesterolemia; intestinal absorption; intestines; linseed; micelles; oils; peptides; solubility; ultrafiltration
Abstract:
... Flaxseed peptides reduced serum cholesterol levels in Sprague–Dawley rats fed with a high‐cholesterol diet. However, the mechanism of this action remains unclear. Flaxseed‐hydrolyzed proteins were separated through ultrafiltration. The fifth fraction (FP₅, ≤ 1 kDa) had the highest cholesterol micelle solubility inhibition rate (CMSR) of 72.39% among the other fractions. Eleven peptides were identi ...
DOI:
10.1111/jfbc.14031

52. Fructooligosaccharide ameliorates high-fat induced intrauterine inflammation and improves lipid profile in the hamster offspring

Author:
Shujauddin Mohammed; Syed Shah Yousuf Qadri; Irfan Ahmad Mir; Narendra Babu Kondapalli; Sanjay Basak; Hemalatha Rajkumar
Source:
Journal of nutritional biochemistry 2022 v.101 pp. 108925
ISSN:
0955-2863
Subject:
adiposity; amniotic fluid; blood serum; energy; females; fructooligosaccharides; glucose; hamsters; high fat diet; inflammation; interleukin-8; lactation; lipid composition; lipid metabolism; neutrophils; placenta; prebiotics; pregnancy; progeny; triacylglycerols
Abstract:
... Maternal high-fat diet (HFD) often results in intrauterine and feto-placental inflammation, and increases the risks of fetal programming of metabolic diseases. Intake of prebiotic is reported beneficial. However, its effects on HFD during pregnancy and lactation is not known. We evaluated the maternal intake of fructooligosaccharide (FOS) and its impact on placental inflammation, offspring's adipo ...
DOI:
10.1016/j.jnutbio.2021.108925

53. Ganoderma lucidum protease hydrolyzate on lipid metabolism and gut microbiota in high-fat diet fed rats

Author:
Yu Xiong; Feng-Li Zhang; Jing-Ru Li; Pei-Zhi Peng; Bin Liu; Li-Na Zhao
Source:
Food bioscience 2022 v.47 pp. 101460
ISSN:
2212-4292
Subject:
Clostridium; Ganoderma lucidum; acetyl-CoA carboxylase; acyl-CoA oxidase; alanine transaminase; aspartate transaminase; blood serum; functional foods; gene expression; high density lipoprotein cholesterol; high fat diet; hydrolysates; intestinal microorganisms; intestines; lipid metabolism; liver; low density lipoprotein cholesterol; protein kinases; proteinases
Abstract:
... In this study, we aimed to evaluate the effect of Ganoderma lucidum protease hydrolysate (GLPH) on lipid metabolism and intestinal flora in rats fed on a high-fat diet. Our research shows that GLPH reduces triglycerides, total cholesterol, low-density lipoprotein cholesterol, alanine aminotransferase and aspartate aminotransferase levels, but increases high-density lipoprotein cholesterol in the s ...
DOI:
10.1016/j.fbio.2021.101460

54. Ginsenoside Rh2 attenuates CDAHFD-induced liver fibrosis in mice by improving intestinal microbial composition and regulating LPS-mediated autophagy

Author:
Siyu Chen; Ziwei He; Wei Xie; Xuan Chen; Zhuofeng Lin; Jisheng Ma; Zhi Liu; Shihai Yang; Yanfang Wang
Source:
Phytomedicine 2022 v.101 pp. 154121
ISSN:
0944-7113
Subject:
Western blotting; autophagy; fibrosis; ginsenosides; high fat diet; histopathology; intestines; lipopolysaccharides; liver; liver cirrhosis; models
Abstract:
... Nowadays, liver diseases are threatening more and more people all over the world and one of the main causes is liver fibrosis. However, there is no effective way to reverse liver fibrosis. To investigate whether ginsenoside Rh2 (G-Rh2) can alleviate liver fibrosis and elucidate its underlying mechanism. In vivo and in vitro methods were adopted in this research. Choline-deficient, L-amino acid-def ...
DOI:
10.1016/j.phymed.2022.154121

55. Ginsenoside compound K ameliorates palmitate-induced atrophy in C2C12 myotubes via promyogenic effects and AMPK/autophagy-mediated suppression of endoplasmic reticulum stress

Author:
Tae Jin Kim; Do Hyeon Pyun; Myeong Jun Kim; Ji Hoon Jeong; A.M. Abd El-Aty; Tae Woo Jung
Source:
Journal of Ginseng Research 2022 v.46 no.3 pp. 444-453
ISSN:
1226-8453
Subject:
Panax; apoptosis; autophagy; endoplasmic reticulum stress; ginsenosides; high fat diet; histology; muscle development; muscular atrophy; myoblasts; myotubes; obesity; palmitates; phosphorylation; protein synthesis; research; skeletal muscle; therapeutics; transfection
Abstract:
... Compound K (CK) is among the protopanaxadiol (PPD)-type ginsenoside group, which produces multiple pharmacological effects. Herein, we examined the effects of CK on muscle atrophy under hyperlipidemic conditions along with its pro-myogenic effects. Further, the molecular pathways underlying the effects of CK on skeletal muscle have been justified. C2C12 myotubes were treated with palmitate and CK. ...
DOI:
10.1016/j.jgr.2021.09.002

56. Glycosides and flavonoids from the extract of Pueraria thomsonii Benth leaf alleviate type 2 diabetes in high-fat diet plus streptozotocin-induced mice by modulating the gut microbiota

Author:
Shan-Shan Zhang; Niu-Niu Zhang; Sen Guo; Shao-Jing Liu; Yu-Fei Hou; Shiming Li; Chi-Tang Ho; Nai-Sheng Bai
Source:
Food & function 2022 v.13 no.7 pp. 3931-3945
ISSN:
2042-650X
Subject:
Clostridium celatum; Pueraria montana var. thomsonii; acarbose; blood glucose; glycolipids; high fat diet; high performance liquid chromatography; inflammation; insulin; intestinal microorganisms; intestines; kaempferol; kidneys; leaves; liver; noninsulin-dependent diabetes mellitus; nuclear magnetic resonance spectroscopy; oxidative toxicity; probiotics; quercetin; quercitrin; rutin
Abstract:
... Twenty glycoside derivatives and nine flavonoids from the leaves of Pueraria (P. thomsonii) were isolated by column chromatography and characterized by nuclear magnetic resonance spectroscopy (NMR) and high performance liquid chromatography (HPLC). The contents of twenty glycosides and nine flavonoids from the extract of P. thomsonii leaf (PL) were 173.3 mg g⁻¹ and 134.7 mg g⁻¹, respectively. Two ...
DOI:
10.1039/d1fo04170c

57. Green tea extract increases adiponectin and PPAR α levels to improve hepatic steatosis

Author:
Marcelo Paradiso Marinovic; Celso Pereira Batista Sousa-Filho; Fernanda Aparecida Heleno Batista; Thayna Mendonca Avelino; Bruno Cogliati; Ana Carolina Migliorini Figueira; Rosemari Otton; Alice Cristina Rodrigues
Source:
Journal of nutritional biochemistry 2022 v.103 pp. 108957
ISSN:
0955-2863
Subject:
adiponectin; antagonists; calorimetry; energy expenditure; epicatechin; epigallocatechin; fatty acid metabolism; fatty liver; glucose; green tea; high fat diet; histology; insulin resistance; ligands; lipids; liver; males; obesity; protocols; therapeutics; transcriptional activation
Abstract:
... We postulated that Green tea (GT) improvements in non–alcoholic fatty liver disease (NAFLD) are dependent on adiponectin action in the liver. Male wild-type and adiponectin knockout (adipoKO) mice were induced to obesity for 8 weeks with a high-fat diet and then treated with GT for the last 12 weeks of the experimental protocol. Glucose and insulin tolerance tests, indirect calorimetry, histologic ...
DOI:
10.1016/j.jnutbio.2022.108957

58. Helminth-induced CD9+ B-cell subset alleviates obesity-associated inflammation via IL-10 production

Author:
Maining Li; Huiquan Wang; Yangyue Ni; Chen Li; Xuejun Xu; Hao Chang; Zhipeng Xu; Min Hou; Minjun Ji
Source:
International journal for parasitology 2022 v.52 no.2-3 pp. 111-123
ISSN:
0020-7519
Subject:
B-lymphocytes; Schistosoma japonicum; helminthiasis; helminths; high fat diet; homeostasis; inflammation; insulin resistance; interleukin-10; mice; obesity; parasitology; sequence analysis; spleen
Abstract:
... It has been shown that helminth infection can protect against obesity and improve insulin sensitivity to a certain extent, based on epidemiological investigations and animal experiments. Meanwhile, helminths induce a network of regulatory immune cells, including regulatory B cells (Bregs). However, the molecule characteristics and function of these Bregs in improving whole-body metabolic homeostas ...
DOI:
10.1016/j.ijpara.2021.08.009

59. Hepatic microRNA modulation might be an early event to non-alcoholic fatty liver disease development driven by high-fat diet in male mice

Author:
Carolina Panzarin; Laís Angélica de Paula Simino; Mariana Camargo Silva Mancini; Leticia Martins Ignácio-Souza; Marciane Milanski; Márcio Alberto Torsoni; Adriana Souza Torsoni
Source:
Molecular biology reports 2022 v.49 no.4 pp. 2655-2666
ISSN:
0301-4851
Subject:
acyl-CoA dehydrogenase; adiposity; body weight; carnitine palmitoyltransferase; cell lines; chronic exposure; fatty liver; gene expression; glucose; glycogen; high fat diet; homeostasis; insulin; interleukin-6; lipid content; males; microRNA; molecular biology; protein kinases; protein subunits
Abstract:
... INTRODUCTION: Metabolic alterations caused by an imbalance of macronutrient consumption are often related to the modulation of microRNAs (miRNAs), which could alter mRNAs expression profile and accelerate the development of non-alcoholic fatty liver disease (NAFLD). AIMS: This study aimed to investigate the contribution of miRNAs in modulating early stages of NAFLD in mice submitted to a high-fat ...
DOI:
10.1007/s11033-021-07072-8

60. High glucose stimulating ECM remodeling and an inflammatory phenotype in the IPFP via upregulation of MFAP5 expression

Author:
Xiao-ying Dong; Jing-xia Yin; Hao Zhang; Yong Liao
Source:
Biochemical and biophysical research communications 2022 v.601 pp. 93-100
ISSN:
0006-291X
Subject:
cartilage; diabetes; extracellular matrix; fibrosis; glucose; high fat diet; inflammation; interleukin-6; mice; osteoarthritis; phenotype; research; streptozotocin; therapeutics; transcriptomics
Abstract:
... Extracellular matrix (ECM) remodeling and inflammation in the infrapatellar fat pad (IPFP) are associated with cartilage degeneration and the severity of osteoarthritis (OA). Diabetes is associated with the progression of OA. However, it is still unclear whether diabetes can promote osteoarthritis by targeting the IPFP. In this study, we established a high-fat diet/streptozotocin (HFD/STZ)-induced ...
DOI:
10.1016/j.bbrc.2022.02.077

61. High-fat diet intake ameliorates the expression of hedgehog signaling pathway in adult rat liver

Author:
Rabia Mehmood; Nadeem Sheikh; Muhammad Babar Khawar; Muddasir Hassan Abbasi; Maryam Mukhtar
Source:
Molecular biology reports 2022 v.49 no.3 pp. 1985-1994
ISSN:
0301-4851
Subject:
Erinaceidae; Rattus norvegicus; adults; animal models; biomarkers; collagen; fatty liver; fibrosis; gene expression; hepatocytes; high fat diet; hypertriglyceridemia; inflammation; lipid composition; liver; liver cirrhosis; molecular biology; necrosis; neutropenia; polycythemia; rats; very low density lipoprotein
Abstract:
... BACKGROUND: Disproportionate fatty diet intake provokes hepatic lipid accumulation that causes non-alcoholic fatty liver disease, triggering the embryonically conserved Hedgehog (Hh) pathway in the adult liver. The present study incorporates exploring the impact of chronically administered unsaturated (D-1) and saturated (D-2) fat-enriched diets on hematological parameters, liver functioning, and ...
DOI:
10.1007/s11033-021-07012-6

62. High‐Fat‐Diet‐Induced Extracellular Matrix Deposition Regulates Integrin—FAK Signals in Adipose Tissue to Promote Obesity

Author:
Hui‐jian Chen; Xi‐yue Yan; Ao Sun; Li Zhang; Jing Zhang; You‐e Yan
Source:
Molecular nutrition & food research 2022 v.66 no.7 pp. e2101088
ISSN:
1613-4125
Subject:
adipocytes; adipogenesis; collagen; extracellular matrix; food research; glucose; high fat diet; humans; integrins; laminin; mitogen-activated protein kinase; non-specific protein-tyrosine kinase; obesity; oleic acid; phosphorylation; therapeutics; white adipose tissue
Abstract:
... SCOPE: High‐fat‐diet (HFD) is an important factor in obesity. Extracellular matrix (ECM) regulates white adipose tissue (WAT), but its mechanism is unknown. METHODS AND RESULTS: This study uses three models—HFD‐fed mice, human with obesity, and 3T3‐L1 adipocytes with oleic acid (OA)/macromolecular crowders (MMC) treatment. Glucose and lipids metabolic disorders, increased collagen I/IV and laminin ...
DOI:
10.1002/mnfr.202101088

63. In vivo activities of the structured lipids -1, 3-dioleic acid 2-palmitic acid triglyceride (OPO) in high-fat diet mice

Author:
Yuyang Huang; Na Wang; Haitian Zhao
Source:
Food bioscience 2022 v.47 pp. 101667
ISSN:
2212-4292
Subject:
alanine transaminase; antioxidants; aspartate transaminase; biomarkers; blood serum; body weight; catalase; enzyme activity; glutathione peroxidase; high density lipoprotein cholesterol; high fat diet; hyperlipidemia; hypertrophy; kidneys; lipid metabolism; liver; low density lipoprotein cholesterol; males; models; oxidative stress; superoxide dismutase; triacylglycerols
Abstract:
... High-energy diets and lipid metabolism can lead to high levels of total cholesterol, a decrease in antioxidant, enzyme activity, and an increase in oxidative stress and dyslipidemia biomarker. In this study, the in vivo antihyperlipidemic and antioxidant effects of 1, 3-dioleoyl-2-palmitoyl triglyceride (OPO) using a high fat-diet model were investigated. The mice were divided into groups includin ...
DOI:
10.1016/j.fbio.2022.101667

64. Indole alkaloids of Alstonia scholaris (L.) R. Br. alleviated nonalcoholic fatty liver disease in mice fed with high-fat diet

Author:
Shui-Fen Sun; Hui-Jie Zhong; Yun-Li Zhao; Xiu-Ying Ma; Jin-Bo Luo; Ling Zhu; Yu-Ting Zhang; Wen-Xue Wang; Xiao-Dong Luo; Jia-Wei Geng
Source:
Natural products and bioprospecting 2022 v.12 no.1 pp. 14
ISSN:
2192-2195
Subject:
Alstonia scholaris; acetyl-CoA carboxylase; acyl-CoA oxidase; alanine transaminase; aspartate transaminase; beta oxidation; body weight; carnitine; coenzyme A; diabetes; droplets; fatty liver; high density lipoprotein; high fat diet; histopathology; lipogenesis; liver; low density lipoprotein; medicinal plants; models; sterols; triacylglycerols
Abstract:
... Alstonia scholaris (L.) R. Br (Apocynaceae) is a well-documented medicinal plant for treating respiratory diseases, liver diseases and diabetes traditionally. The current study aimed to investigate the effects of TA on non-alcoholic fatty liver disease (NAFLD). A NAFLD model was established using mice fed a high-fat diet (HFD) and administered with TA (7.5, 15 and 30 mg/kg) orally for 6 weeks. The ...
DOI:
10.1007/s13659-022-00335-2

65. Inherited Metabolic Memory of High‐Fat Diet Impairs Testicular Fatty Acid Content and Sperm Parameters

Author:
Luís Crisóstomo; Romeu A. Videira; Ivana Jarak; Kristina Starčević; Tomislav Mašek; Luís Rato; João F. Raposo; Rachel L. Batterham; Pedro F. Oliveira; Marco G. Alves
Source:
Molecular nutrition & food research 2022 v.66 no.5 pp. e2100680
ISSN:
1613-4125
Subject:
3-hydroxybutyric acid; antioxidant enzymes; blood serum; choline; energy metabolism; enzyme activity; fatty acid composition; fatty acid metabolism; food research; glucose; high fat diet; homeostasis; insulin resistance; metabolites; mitochondria; spermatozoa; testes
Abstract:
... SCOPE: Exposure to a high‐fat diet (HFD) from early‐life is associated with a testicular metabolic signature link to abnormal sperm parameters up to two generations after exposure in mice. Hereby, this study describes a testicular lipid signature associate with “inherited metabolic memory” of exposure to HFD, persisting up to two generations in mice. METHODS AND RESULTS: Diet‐challenged mice (n = ...
DOI:
10.1002/mnfr.202100680

66. Integrated proteome and phosphoproteome analysis of interscapular brown adipose and subcutaneous white adipose tissues upon high fat diet feeding in mouse

Author:
Yuqiu Wang; Junmin Li; Dayun Lu; Qian Meng; Nixue Song; Hu Zhou; Xiao Xiao; Liming Sun; Hongwen Zhu
Source:
Journal of proteomics 2022 v.255 pp. 104500
ISSN:
1874-3919
Subject:
beta oxidation; brown adipose tissue; data collection; heat production; high fat diet; mass spectrometry; mice; mitochondria; obesity; obesity-related diseases; oxidative phosphorylation; phosphoproteome; phosphotransferases (kinases); proteomics; thermic effect of food; tricarboxylic acid cycle; weight gain; white adipose tissue
Abstract:
... Thermogenesis is a promising approach to limit weight gain in response to excess nutrition. In contrast to cold-induced thermogenesis, the molecular and cellular mechanisms of diet-induced thermogenesis (DIT) have not been fully characterized. Here, we explored the response of brown adipose tissue (BAT) and subcutaneous white adipose tissue (sWAT) to high fat diet (HFD) using proteome and phosphop ...
DOI:
10.1016/j.jprot.2022.104500

67. Lactobacillus paracasei 24 Attenuates Lipid Accumulation in High-Fat Diet-Induced Obese Mice by Regulating the Gut Microbiota

Author:
Zhijing Liu; Xuan Zhou; Wan Wang; Liya Gu; Chuanbing Hu; Hong Sun; Cong Xu; Juncai Hou; Zhanmei Jiang
Source:
Journal of agricultural and food chemistry 2022 v.70 no.15 pp. 4631-4643
ISSN:
1520-5118
Subject:
Bacteroidetes; Lactobacillus paracasei; blood lipids; fatty liver; food chemistry; high fat diet; inflammation; intestinal microorganisms; lactic acid; lipid metabolism; lipids; liver; mice; obesity; oxidative stress; probiotics; public health
Abstract:
... Obesity has become a worldwide public health problem. Lactic acid bacteria have attracted extensive attention for alleviating obesity and fat accumulation. This study aimed to evaluate the alleviating effects of Lactobacillus paracasei 24 (LP24) on lipid accumulation in an obese mouse model induced by a high-fat diet (HFD). The results showed that LP24 treatment significantly reduced body weight a ...
DOI:
10.1021/acs.jafc.1c07884

68. Lactobacillus rhamnosus Strain LRH05 Intervention Ameliorated Body Weight Gain and Adipose Inflammation via Modulating the Gut Microbiota in High‐Fat Diet‐Induced Obese Mice

Author:
Yung‐Tsung Chen; Shiou‐Yun Chiou; Ai‐Hua Hsu; Yu‐Chun Lin; Jin‐Seng Lin
Source:
Molecular nutrition & food research 2022 v.66 no.1 pp. e2100348
ISSN:
1613-4125
Subject:
Fusobacterium; Lactobacillus reuteri; Lactobacillus rhamnosus; adipogenesis; body weight changes; butyric acid; fatty liver; food research; gene expression; glucose; high fat diet; inflammation; intestinal microorganisms; macrophages; mice; obesity; probiotics; propionic acid; triacylglycerols; white adipose tissue
Abstract:
... SCOPE: This study aims to investigate the underlying mechanism of a specific probiotic strain on suppression of adipogenesis and inflammatory response in white adipose tissue (WAT) of high‐fat diet (HFD)‐fed mice. METHODS AND RESULTS: Eight strains are screened in vitro for candidates of potential probiotics. Lactobacillus rhamnosus LRH05 (LRH05) and Lactobacillus reuteri LR47 (LR47) are screened ...
DOI:
10.1002/mnfr.202100348

69. Lipids and diastolic dysfunction: Recent evidence and findings

Author:
Padideh Daneii; Sina Neshat; Monir Sadat Mirnasiry; Zahra Moghimi; Fatemeh Dehghan Niri; Armita Farid; Masood Shekarchizadeh; Kiyan Heshmat-Ghahdarijani
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 pp. -
ISSN:
0939-4753
Subject:
fat thickness; fatty liver; gender; heart failure; high fat diet; histology; inflammation; lipid content; lipid metabolism; lipotoxicity; metabolic syndrome; myocardium; obesity; oxidative stress; pathogenesis
Abstract:
... Diastolic dysfunction is the decreased flexibility of the left ventricle due to the impaired ability of the myocardium to relax and plays an important role in the pathogenesis of heart failure. Lipid metabolism is a well-known contributor to cardiac conditions, including ventricular function. In this article, we aimed to review the literature addressing the connections between lipids, their storag ...
DOI:
10.1016/j.numecd.2022.03.003

70. Liver-specific overexpression of SIRT3 enhances oxidative metabolism, but does not impact metabolic defects induced by high fat feeding in mice

Author:
Brenna Osborne; Jane Reznick; Lauren E. Wright; David A. Sinclair; Gregory J. Cooney; Nigel Turner
Source:
Biochemical and biophysical research communications 2022 v.607 pp. 131-137
ISSN:
0006-291X
Subject:
aerobiosis; body composition; enzymes; glucose tolerance; hepatocytes; high fat diet; insulin resistance; liver; mitochondria; obesity; oxygen consumption; protein synthesis; research; triacylglycerols
Abstract:
... The mitochondrial enzyme SIRT3 is an NAD⁺-dependent deacetylase important in cell metabolism, and a decline in its protein expression or activity has been linked with insulin resistance in obesity, ageing and type 2 diabetes. While studies in SIRT3 knockout mice have dramatically improved our understanding of the function of SIRT3, the impact of increasing SIRT3 levels remains under-examined. In t ...
DOI:
10.1016/j.bbrc.2022.03.088

71. LncRNA Tug1 maintains blood–testis barrier integrity by modulating Ccl2 expression in high-fat diet mice

Author:
Shuxian Wang; Zhang Qian; Xie Ge; Chuwei Li; Mengqi Xue; Kuan Liang; Rujun Ma; Lei Ouyang; Lu Zheng; Jun Jing; Siyuan Cao; Yu Zhang; Yang Yang; Yabing Chen; Jinzhao Ma; Bing Yao
Source:
Cellular and molecular life sciences 2022 v.79 no.2 pp. 114
ISSN:
1420-682X
Subject:
chromatin immunoprecipitation; electrical resistance; high fat diet; male sterility; mice; palmitic acid; permeability; promoter regions; sequence analysis; sperm quality; spermatogenesis; tight junctions
Abstract:
... Sertoli cells are essential for spermatogenesis in the testicular seminiferous tubules by forming blood–testis barrier (BTB) and creating a unique microenvironment for spermatogenesis. Many lncRNAs have been reported to participate in spermatogenesis. However, the role of long noncoding RNAs (lncRNAs) in Sertoli cells has rarely been examined. Herein, we found that a high-fat diet (HFD) decreased ...
DOI:
10.1007/s00018-022-04142-3

72. Maternal Isocaloric High‐Fat Diet Induces Liver Mitochondria Maladaptations and Homeostatic Disturbances Intensifying Mitochondria Damage in Response to Fructose Intake in Adult Male Rat Offspring

Author:
Aline F. P. Souza; Juliana Woyames; Rosiane A. Miranda; Lorraine S. Oliveira; Bruna Caetano; Isabela L. Martins; Manuella S. Souza; Cherley B. V. Andrade; Thais Bento‐Bernardes; Flavia F. Bloise; Rodrigo S. Fortunato; Isis H. Trevenzoli; Luana L. Souza; Carmen C. Pazos‐Moura
Source:
Molecular nutrition & food research 2022 v.66 no.8 pp. e2100514
ISSN:
1613-4125
Subject:
adulthood; adults; autophagy; females; food research; fructose; high fat diet; insulin resistance; lactation; lipids; liver; males; mitochondria; obesity; oxygen consumption; progeny; rats; risk
Abstract:
... SCOPE: Perinatal maternal obesity and excessive fructose consumption have been associated with liver metabolic diseases. The study investigates whether moderate maternal high‐fat diet affects the liver mitochondria responses to fructose intake in adult offspring. METHODS AND RESULTS: Wistar female rats have received a standard diet (mSTD) or high‐fat diet (mHFD) (9% and 28.6% fat, respectively), b ...
DOI:
10.1002/mnfr.202100514

73. Maternal consumption of ɷ3 attenuates metabolic disruption elicited by saturated fatty acids-enriched diet in offspring rats

Author:
Debora S. Alves-de-Oliveira; Aline M.N.L.G. Bloise; Laura M.L. Silva; Reginaldo L. Rocha-Junior; Nelson C. Lima-Júnior; Luiza G.S. Menezes; Elionay G.S. Silva; Yohanna De Oliveira; Almir G. Wanderley; José L. de-Brito-Alves; Viviane O.N. Souza; João H. Costa-Silva
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.1 pp. 279-289
ISSN:
0939-4753
Subject:
adulthood; adults; birth weight; blood serum; food consumption; glucose; high fat diet; hyperlipidemia; insulin; lactation; lipids; metabolism; pregnancy; progeny; pyruvic acid; rats; risk
Abstract:
... High-fat diet (HFD) intake during gestation and lactation has been associated with an increased risk of developing cardiometabolic disorders in adult offspring. We investigated whether metabolic alterations resulting from the maternal consumption of HFD are prevented by the addition of omega-3 (ɷ3) in the diet.Wistar rat dams were fed a control (C: 19% of lipids and ɷ6:ɷ3 = 12), HF (HF: 33% lipids ...
DOI:
10.1016/j.numecd.2021.09.010

74. Maternal high-fat diet aggravates fructose-induced mitochondrial damage in skeletal muscles and causes differentiated adaptive responses on lipid metabolism in adult male offspring

Author:
Juliana Woyames; Aline Fonseca Pereira Souza; Rosiane Aparecida Miranda; Lorraine Soares Oliveira; Bruna Caetano; Cherley Borba Vieira Andrade; Rodrigo Soares Fortunato; Georgia Correa Atella; Isis Hara Trevenzoli; Luana Lopes Souza; Carmen Cabanelas Pazos-Moura
Source:
Journal of nutritional biochemistry 2022 v.104 pp. 108976
ISSN:
0955-2863
Subject:
H-transporting ATP synthase; adults; fatty acid composition; fatty acid-binding proteins; females; fructose; glycolysis; high fat diet; hypertriglyceridemia; lipid peroxidation; lipogenesis; males; maternal nutrition; mitochondria; monounsaturated fatty acids; progeny; skeletal muscle
Abstract:
... Maternal high-fat diet (HFD) is associated with metabolic disturbances in the offspring. Fructose is a highly consumed lipogenic sugar; however, it is unknown whether skeletal muscle of maternal HFD offspring respond differentially to a fructose overload. Female Wistar rats received standard diet (STD: 9% fat) or isocaloric high-fat diet (HFD: 29% fat) during 8 weeks before mating until weaning. A ...
DOI:
10.1016/j.jnutbio.2022.108976

75. Melatonin supplementation preserves testicular function by attenuating lactate production and oxidative stress in high fat diet-induced obese rat model

Author:
Azeezat O. Saidi; Christopher O. Akintayo; Chukwubueze L. Atuma; Hadiza Mahmud; Isaiah W. Sabinari; Adesola A. Oniyide; Ayodeji Aturamu; Toluwani B. Agunbiade; Kehinde S. Olaniyi
Source:
Theriogenology 2022 v.187 pp. 19-26
ISSN:
0093-691X
Subject:
adults; animal reproduction; cholesterol; glutathione; glutathione peroxidase; high fat diet; lactic acid; male fertility; males; malondialdehyde; melatonin; metabolic syndrome; nitric oxide; obesity; oxidative stress; pyruvic acid; testes; testosterone; therapeutics; triacylglycerols
Abstract:
... Metabolic syndrome, including obesity has been documented as a critical factor in male reproductive dysfunction with subsequent reduction in male fertility. The therapeutic potential of melatonin has been demonstrated against oxidative stress-induced pathologies. Therefore, the present study investigated the effects of melatonin on testicular dysfunction associated with high fat diet (FD)-induced ...
DOI:
10.1016/j.theriogenology.2022.02.029

76. Mesenteric lymph system constitutes the second route in gut–liver axis and transports metabolism-modulating gut microbial metabolites

Author:
Ying Yu; Bin Liu; Xiaolin Liu; Xuan Zhang; Wenhui Zhang; He Tian; Guanghou Shui; Wenzhao Wang; Moshi Song; Jun Wang
Source:
Journal of genetics and genomics 2022 pp. -
ISSN:
1673-8527
Subject:
blood circulation; blood serum; carnitine; genomics; high fat diet; intestinal microorganisms; liver; lymph; mesentery; metabolism; metabolites; metabolome; obesity; portal vein; transportation
Abstract:
... The gut–liver axis denotes the intricate connection and interaction between gut microbiome and liver, in which compositional and functional shifts in gut microbiome affect host metabolism. Hepatic portal vein of the blood circulation system has been thought to be the major route for metabolite transportation in the gut–liver axis, but the existence and importance of other routes remain elusive. He ...
DOI:
10.1016/j.jgg.2022.03.012

77. Metabolomic profiling of M. speciosa champ at different growth stages

Author:
Maoyuan Wang; Mei Zhang; Qing Yang; Qinglong Wang; Bokai Ma; Zhiying Li; Wen Cheng; Huan Tang; Shixiu Feng; Zhunian Wang
Source:
Food chemistry 2022 v.376 pp. 131941
ISSN:
0308-8146
Subject:
Millettia; fatty liver; food chemistry; harvest date; hepatoprotective effect; high fat diet; metabolomics; nuclear magnetic resonance spectroscopy; traditional medicine
Abstract:
... Millettia speciosa Champ (M. speciosa) is an edible food and folk medicine and extracts from its roots exhibit a hepatoprotective effect. However, its metabolic growth process and the best harvest time have not been reported. This study systematically evaluated the metabolomic profiling of M. speciosa root extracts at different growth stages through the UPLC-Q-TOF-MS, nuclear magnetic resonance (N ...
DOI:
10.1016/j.foodchem.2021.131941

78. Methanolic fruit extract of Myrica nagi protects the hypothalamus and attenuates inflammation associated with gold thioglucose- and high-fat diet-induced obesity via various adipokines

Author:
Yash Prashar; Nilesh J. Patel
Source:
Journal of Ayurveda and integrative medicine 2022 pp. 100582
ISSN:
0975-9476
Subject:
Ayurvedic medicine; Myrica; absorption; adiponectin; adipose tissue; anti-obesity effects; biomarkers; blood lipids; blood serum; cardiovascular diseases; chemoattractants; energy expenditure; enzyme activity; feed intake; fruit extracts; fruits; gastrointestinal system; gold; high fat diet; histopathology; hypothalamus; inflammation; insulin; leptin; lipid composition; lipids; liver; monocytes; myricetin; obesity; resistin; weight gain; weight loss
Abstract:
... Myrica nagi is popular in unani and ayurveda. Chemical constituents like myricetin isolated from its fruit has been shown to exert beneficial effects against cardiovascular disease, cancer, inflammatory conditions, and metabolic disorders. This study aimed to elucidate the anti-obesity effect of the methanolic extract of M. nagi (MEMN) using in vivo animal models of obesity induced by gold thioglu ...
DOI:
10.1016/j.jaim.2022.100582

79. Monascus vinegar protects against liver inflammation in high-fat-diet rat by alleviating intestinal microbiota dysbiosis and enteritis

Author:
Huanmei Meng; Jia Song; Yingqi Li; Xuan Li; Xinyue Li; Jia Gou; Zhiqiang Nie; Jianxin Wang; Yu Zheng; Min Wang
Source:
Journal of functional foods 2022 v.93 pp. 105078
ISSN:
1756-4646
Subject:
Monascus; alanine transaminase; aspartate transaminase; body weight; dysbiosis; enteritis; functional foods; high fat diet; homeostasis; inflammation; intestinal microorganisms; intestines; liver; mitogen-activated protein kinase; non-specific serine/threonine protein kinase; occludins; phosphatidylinositol 3-kinase; prostaglandin synthase; rats; transcriptome; vinegars
Abstract:
... Monascus vinegar (MV) is typical fermented food with anti-inflammatory properties. Liver inflammation induced by high-fat diet (HFD) is closely associated with intestinal homeostasis. This study aimed to assess the protective properties and associated mechanism of MV on liver inflammation in HFD-fed rats from liver transcriptome and gut microbiota. MV mitigated body weight (BW) and liver index. Th ...
DOI:
10.1016/j.jff.2022.105078

80. Moringa oleifera Lam. seed extract protects kidney function in rats with diabetic nephropathy by increasing GSK-3β activity and activating the Nrf2/HO-1 pathway

Author:
Ying Wen; Yanyang Liu; Qi Huang; Rong Liu; Jing Liu; Fengyu Zhang; Shao Liu; Yueping Jiang
Source:
Phytomedicine 2022 v.95 pp. 153856
ISSN:
0944-7113
Subject:
Moringa oleifera; antioxidants; blood; blood glucose; diabetic nephropathy; eosin; fibrosis; glucose; heme oxygenase (biliverdin-producing); high fat diet; humans; immunohistochemistry; kidneys; oxidative stress; protective effect; renal function; seed extracts; therapeutics; traditional medicine; urine; Africa; Middle East
Abstract:
... Moringa oleifera Lam. (M. oleifera) seeds are widely used in traditional folk medicine and as nutritional supplements in the Middle East, Africa, and other regions. Published research showed that M. oleifera seeds (MOS) have pharmacological activities such as blood glucose-lowering, anti-inflammatory, and antitumor effects. However, experimental evidence on the use of MOS to treat diabetic nephrop ...
DOI:
10.1016/j.phymed.2021.153856

81. Mulberry leaf polysaccharides ameliorate obesity through activation of brown adipose tissue and modulation of the gut microbiota in high-fat diet fed mice

Author:
Ruilin Li; Zihan Xue; Shuqin Li; Jingna Zhou; Junyu Liu; Min Zhang; Pharkphoom Panichayupakaranant; Haixia Chen
Source:
Food & function 2022 v.13 no.2 pp. 561-573
ISSN:
2042-650X
Subject:
Western blotting; adipocytes; body weight changes; brown adipose tissue; drug therapy; energy; fatty liver; high fat diet; homeostasis; intestinal microorganisms; leaves; lipid metabolism; mice; mulberries; obesity; polysaccharides; white adipose tissue
Abstract:
... Improving energy homeostasis and the gut microbiota is a promising strategy to improve obesity and related metabolic disorders. Mulberry leaf is one of the traditional Chinese medicines and functional diets. In this work, a mouse model induced by high-fat diet (HFD) was used to reveal the role of mulberry leaf polysaccharides (MLP). It was found that MLP had a significant effect in limiting body w ...
DOI:
10.1039/d1fo02324a

82. Neoagarooligosaccharides modulate gut microbiota and alleviate body weight gain and metabolic syndrome in high-fat diet-induced obese rats

Author:
Ju Kyoung Oh; Robie Vasquez; Sang Hoon Kim; Je Hyeon Lee; Eun Joo Kim; Soon-Kwang Hong; Dae-Kyung Kang
Source:
Journal of functional foods 2022 v.88 pp. 104869
ISSN:
1756-4646
Subject:
Ruminococcaceae; anti-obesity effects; body weight changes; cholesterol; dysbiosis; glucose; high fat diet; intestinal microorganisms; lipogenesis; metabolic syndrome; obesity; oligosaccharides; prebiotics
Abstract:
... Some oligosaccharides function as prebiotics and improve the dysbiosis of the gut microbiota, which affects the health of the host. Recent data suggests that neoagarooligosaccharides (NAOs) can exert anti-obesity effect. However, the effects of NAOs on the gut microbiota and its association with metabolic syndrome have never been explored yet. Therefore, metabolic changes and the modulation of the ...
DOI:
10.1016/j.jff.2021.104869

83. Nobiletin mitigates hepatocytes death, liver inflammation, and fibrosis in a murine model of NASH through modulating hepatic oxidative stress and mitochondrial dysfunction

Author:
Shuyu Li; Xi Li; Fangyuan Chen; Min Liu; Liuxin Ning; Yufeng Yan; Shuncai Zhang; Shaoping Huang; Chuantao Tu
Source:
Journal of nutritional biochemistry 2022 v.100 pp. 108888
ISSN:
0955-2863
Subject:
animal models; apoptosis; calcium; death; electron transport chain; fatty liver; fibrosis; hepatocytes; high fat diet; histology; inflammation; lipid peroxidation; lipids; lipotoxicity; liver; liver cirrhosis; macrophages; mitochondria; oxidative stress; palmitates; reactive oxygen species; therapeutics
Abstract:
... This study aimed to investigate the therapeutic effects of nobiletin (NOB) on nonalcoholic steatohepatitis (NASH) and liver fibrosis in mice and to elucidate its underlying molecular mechanisms. BALB/c mice were fed a normal chow diet or a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) for 8 wks and treated with NOB (50 mg/kg) or vehicle by daily intraperitoneally injection for th ...
DOI:
10.1016/j.jnutbio.2021.108888

84. Novel pharmacological effects of lecithinized superoxide dismutase on ischemia/reperfusion injury in the kidneys of mice

Author:
Ken-ichiro Tanaka; Mikako Shimoda; Maho Kubota; Ayaka Takafuji; Masahiro Kawahara; Tohru Mizushima
Source:
Life sciences 2022 v.288 pp. 120164
ISSN:
0024-3205
Subject:
actin; acute kidney injury; collagen; creatinine; fibrosis; high fat diet; interleukin-6; intravenous injection; ischemia; kidneys; mice; muscles; necrosis; neutrophils; oxidative stress; reactive oxygen species; reperfusion injury; superoxide dismutase; urea nitrogen
Abstract:
... Renal ischemia/reperfusion (I/R) injury is a major clinical problem because it can cause acute kidney injury (AKI) or lead to the transition from AKI to chronic kidney disease (CKD). Oxidative stress, which involves the production of reactive oxygen species (ROS), plays an important role in the development and exacerbation of I/R-induced kidney injury. However, we have previously reported that lec ...
DOI:
10.1016/j.lfs.2021.120164

85. Obesity-Related Brain Cholinergic System Impairment in High-Fat-Diet-Fed Rats

Author:
Ilenia Martinelli; Seyed Khosrow Tayebati; Proshanta Roy; Maria Vittoria Micioni Di Bonaventura; Michele Moruzzi; Carlo Cifani; Francesco Amenta; Daniele Tomassoni
Source:
Nutrients 2022 v.14 no.6 pp. -
ISSN:
2072-6643
Subject:
Western blotting; acetylcholine; acetylcholinesterase; blood glucose; choline acetyltransferase; chronic exposure; frontal lobe; high fat diet; hippocampus; immunohistochemistry; insulin; lipid peroxidation; malondialdehyde; muscarine receptors; nicotinic receptors; obesity; systolic blood pressure
Abstract:
... A link between obesity and cerebral health is receiving growing recognition. Here, we investigate in the frontal cortex and hippocampus the potential involvement of cholinergic markers in brain alterations previously reported in rats with obesity induced by diet (DIO) after long-term exposure (17 weeks) to a high-fat diet (HFD) in comparison with animals fed with a standard diet (CHOW). The obesit ...
DOI:
10.3390/nu14061243

86. Pancreatic islet cells disarray, apoptosis, and proliferation in obese mice. The role of Semaglutide treatment

Author:
Thatiany de Souza Marinho; Fabiane Ferreira Martins; Luiz Eduardo de Macedo Cardoso; Marcia Barbosa Aguila; Carlos Alberto Mandarim-de-Lacerda
Source:
Biochimie 2022 v.193 no. pp. 126-136
ISSN:
0300-9084
Subject:
apoptosis; cell proliferation; confocal microscopy; fibrosarcoma; fluorescent antibody technique; glucagon-like peptide 1; glucose; glucose transporters; high fat diet; hypertrophy; immunohistochemistry; insulin resistance; islets of Langerhans; males; metabolism; mice; obesity; oncogenes; peroxisome proliferator-activated receptor alpha; weight loss
Abstract:
... There are significant injuries of pancreatic islets due to obesity and insulin resistance. Therefore, GLP-1 receptor agonists like Semaglutide might benefit the islet structural remodeling and its endocrine function in diet-induced obese mice. One-month-old male C57BL/6 mice were allotted into two dietary groups (n = 60/group) and fed for 16 weeks a control diet (C) or a high‒fat diet (HF). Then, ...
DOI:
10.1016/j.biochi.2021.10.017

87. Pediococcus acidilactici FZU106 alleviates high-fat diet-induced lipid metabolism disorder in association with the modulation of intestinal microbiota in hyperlipidemic rats

Author:
Qing Zhang; Wei-Ling Guo; Gui-Mei Chen; Min Qian; Jin-Zhi Han; Xu-Cong Lv; Li-Jiao Chen; Ping-Fan Rao; Lian-Zhong Ai; Li Ni
Source:
Current research in food science 2022 v.5 pp. 775-788
ISSN:
2665-9271
Subject:
Erysipelothrix; Facklamia; Globicatella; Oscillospira; Pediococcus acidilactici; Psychrobacter; bile acids; blood serum; body weight; gene expression; high fat diet; histopathology; homeostasis; hyperlipidemia; intestinal microorganisms; intestines; lipid metabolism; liver; oxidative stress; probiotics; research; rice wines
Abstract:
... Probiotics have been proved to have beneficial effects in improving hyperlipidemia. The purpose of the current research was to investigate the ameliorative effects of Pediococcus acidilactici FZU106, isolated from the traditional brewing of Hongqu rice wine, on lipid metabolism and intestinal microbiota in high-fat diet (HFD)-induced hyperlipidemic rats. Results showed that P. acidilactici FZU106 ...
DOI:
10.1016/j.crfs.2022.04.009

88. Phosphatidylmannoside prevents obesity induced by high-fat feeding

Author:
Yanjun Liu; Ziwei Li; Junyi Liu; Jie Xu; Yuanfa Liu; Changhu Xue
Source:
Food bioscience 2022 v.46 pp. 101537
ISSN:
2212-4292
Subject:
adipose tissue; bioavailability; blood; diabetes; dietary supplements; fatty acids; glucose tolerance; high fat diet; insulin resistance; liver; mannose; obesity; phospholipases; urinary tract diseases
Abstract:
... Emerging evidence suggests that dietary d-mannose, enriched naturally in many plants and fruits, show benefits in patients with bacterial urinary tract infection, diabetes, and obesity. However, it is noteworthy that the physiological level of d-mannose in the blood is relatively low. Based on the study that d-mannose could be a safe and beneficial dietary supplement to obese, here phosphatidylati ...
DOI:
10.1016/j.fbio.2021.101537

89. Polygonatum sibiricum polysaccharides protect against obesity and non-alcoholic fatty liver disease in rats fed a high-fat diet

Author:
Li Zeng; Fangwei Zhong; Zhiliang Chen; Gengxi Li; Qi Zhu
Source:
Food science and human wellness 2022 v.11 no.4 pp. 1045-1052
ISSN:
2213-4530
Subject:
AMP-activated protein kinase; Liliaceae; Polygonatum sibiricum; alanine transaminase; aspartate transaminase; blood serum; catalase; fatty liver; food science; glutathione peroxidase; high density lipoprotein cholesterol; high fat diet; humans; immunity; immunoblotting; inflammation; insulin receptors; insulin resistance; interleukin-6; lipid metabolism; liver; low density lipoprotein cholesterol; malondialdehyde; necrosis; neoplasms; obesity; oxidative stress; phosphorylation; polysaccharides; protective effect; superoxide dismutase; triacylglycerols
Abstract:
... Polygonatum sibiricum is a traditional medicinal and dietary plant of the family Liliaceae. The main functional macromolecules of P. sibiricum are polysaccharides, which function in antioxidation and regulating immunity. Previous studies have shown that insulin resistance (IR), oxidative stress, and inflammation are important factors in the induction of lipid metabolic diseases such as obesity. Th ...
DOI:
10.1016/j.fshw.2022.03.031

90. Polysaccharide from Agrocybe cylindracea prevents diet-induced obesity through inhibiting inflammation mediated by gut microbiota and associated metabolites

Author:
Zhenjun Zhu; Rui Huang; Aohuan Huang; Juan Wang; Wei Liu; Shujian Wu; Mengfei Chen; Moutong Chen; Yizhen Xie; Chunwei Jiao; Jumei Zhang; Qingping Wu; Yu Ding
Source:
International journal of biological macromolecules 2022 v.209 pp. 1430-1438
ISSN:
0141-8130
Subject:
Agrocybe; Bacteroides; Desulfovibrio; anti-obesity effects; high fat diet; inflammation; insulin resistance; interleukin-6; intestinal microorganisms; lipids; liver; metabolites; obesity; polysaccharides; prebiotics; sialic acid; therapeutics; tumor necrosis factor-alpha
Abstract:
... Polysaccharide from Agrocybe cylindracea (ACP) has been demonstrated with various health benefits, but its anti-obesity effect and underlying mechanisms remain poorly understood. This study aimed to investigate the beneficial effects of ACP in high-fat diet (HFD)-induced obese mice by targeting gut microbiota and metabolites. 9-week ACP supplementation in HFD-fed mice reduced body weight, adipose ...
DOI:
10.1016/j.ijbiomac.2022.04.107

91. Polysaccharides from Cordyceps militaris prevent obesity in association with modulating gut microbiota and metabolites in high-fat diet-fed mice

Author:
Rui Huang; Zhenjun Zhu; Shujian Wu; Juan Wang; Mengfei Chen; Wei Liu; Aohuan Huang; Jumei Zhang; Qingping Wu; Yu Ding
Source:
Food research international 2022 v.157 pp. 111197
ISSN:
0963-9969
Subject:
Cordyceps militaris; absorption barrier; anti-obesity effects; cytokines; digestive system; dysbiosis; food research; glucose tolerance; high fat diet; intestinal microorganisms; metabolites; metabolomics; obesity; polysaccharides; prebiotics
Abstract:
... Improved gut microbes and nutritious metabolites have been considered as the mediators of health benefits from indigestible polysaccharides, but their role in the anti-obesity effect of polysaccharides from Cordyceps militaris (CMP) remains elusive. This study aims to explore the potential mediators of the anti-obesity effects of CMP in high-fat diet (HFD)-fed mice using 16S rRNA sequencing and un ...
DOI:
10.1016/j.foodres.2022.111197

92. Polysaccharides from Enteromorpha prolifera improves insulin sensitivity and promotes adipose thermogenesis in diet-induced obese mice associated with activation of PGC-1α-FNDC5/irisin pathway

Author:
Fei Xie; Tiande Zou; Jun Chen; Pengbo Liang; Zirui Wang; Jinming You
Source:
Journal of functional foods 2022 v.90 pp. 104994
ISSN:
1756-4646
Subject:
Ulva prolifera; adiposity; blood serum; brown adipose tissue; carbon dioxide production; dietary supplements; energy expenditure; energy metabolism; heat production; high fat diet; inflammation; insulin; insulin resistance; males; obesity; oxygen consumption; polysaccharides; therapeutics; white adipose tissue
Abstract:
... Polysaccharide from Enteromorpha prolifera (EPP) has therapeutic and nutraceutical potential for obesity management due to its high hypolipidaemic activity. However, the metabolic mechanism by which EPP mediates anti-adiposity effects are not fully understood. This study aimed to evaluate the effects of EPP on insulin signaling and adaptive thermogenesis in high-fat diet (HFD)-fed obese mice, and ...
DOI:
10.1016/j.jff.2022.104994

93. Polysaccharides from edible brown seaweed Undaria pinnatifida are effective against high-fat diet-induced obesity in mice through the modulation of intestinal microecology

Author:
Panpan Zhang; Jinhui Jia; Pingrui Jiang; Weiyun Zheng; Xiangfei Li; Shuang Song; Chunqing Ai
Source:
Food & function 2022 v.13 no.5 pp. 2581-2593
ISSN:
2042-650X
Subject:
Bacteroides; Clostridiales; Lactobacillales; Undaria pinnatifida; alginates; bacterial culture; body composition; dysbiosis; high fat diet; inflammation; intestinal microorganisms; intestines; lipids; models; obesity; physiological state
Abstract:
... Brown seaweed is rich in polysaccharides including sulfated polysaccharides and alginate, both of which provide health benefits to the host but whose differences have not received sufficient attention. In this study, alginate from Undaria pinnatifida (UPA) and sulfated polysaccharides from U. pinnatifida (UPSP) were isolated, and their action was analyzed in high fat diet-fed mice. UPA and UPSP im ...
DOI:
10.1039/d1fo04012j

94. Polystyrene nanoplastics potentiate the development of hepatic fibrosis in high fat diet fed mice

Author:
Ling Li; Minjie Xu; Chao He; Hui Wang; Qinglian Hu
Source:
Environmental toxicology 2022 v.37 no.2 pp. 362-372
ISSN:
1520-4081
Subject:
chronic hepatitis; collagen; ecotoxicology; fatty liver; high fat diet; inflammation; intravenous injection; lipid metabolism; lipids; liver; liver cirrhosis; nanoplastics; oxidative stress; oxidative toxicity; polystyrenes; superoxide dismutase
Abstract:
... Polystyrene nanoparticles (PS‐NPs) as an issue of global environmental concern, have been shown to induce hepatic toxicity via triggering oxidative injury and inflammation. Non‐alcoholic fatty liver disease (NAFLD) is initiated when excessive lipid is accumulated in the liver and will proceed to liver fibrosis with repeatedly chronic liver injury. In this study, we examined whether intravenous inj ...
DOI:
10.1002/tox.23404

95. Pomegranate peel anthocyanins prevent diet-induced obesity and insulin resistance in association with modulation of the gut microbiota in mice

Author:
Haizhao Song; Xinchun Shen; Rou Deng; Qiang Chu; Xiaodong Zheng
Source:
European journal of nutrition 2022 v.61 no.4 pp. 1837-1847
ISSN:
1436-6207
Subject:
anthocyanins; biomarkers; body weight changes; energy; food intake; gene expression; glucose; high fat diet; insulin resistance; intestinal microorganisms; intragastric administration; lipid metabolism; low fat diet; males; obesity; pomegranates; specific pathogen-free animals
Abstract:
... PURPOSE: Pomegranate peels are rich in anthocyanins. The present study aimed to explore the beneficial effects of pomegranate peel anthocyanins (PPA) on obesity and gut microbiota in mice with high-fat diet (HFD)-induced obesity. METHODS: Specific pathogen-free (SPF) male C57BL/6 J mice were randomly divided into three groups and fed with low-fat diet (LFD, 10% fat energy), HFD (45% fat energy), o ...
DOI:
10.1007/s00394-021-02771-1

96. Prefrontal Cortex and Hippocampus Inflammation in Mice Fed High-Carbohydrate or High-Fat Diets

Author:
Marina Masetto Antunes; Guilherme Godoy; Laureane Nunes Masi; Rui Curi; Roberto Barbosa Bazotte
Source:
Journal of medicinal food 2022 v.25 no.1 pp. 110-113
ISSN:
1557-7600
Subject:
allografting; caspase-3; caspase-9; functional foods; gene expression; high carbohydrate diet; high fat diet; hippocampus; inducible nitric oxide synthase; inflammation; integrins; interleukin-10; interleukin-4; interleukin-6; liver; males; prefrontal cortex; prostaglandin synthase; skeletal muscle; tumor necrosis factor-alpha
Abstract:
... We previously reported that a high-carbohydrate diet (HCD) induced systemic inflammation and higher gene expression of proinflammatory mediators in the liver, skeletal muscle, and brain than a high-fat diet (HFD). However, the differences between the groups were less pronounced in the brain. In this study, we extended the evaluation of inflammation to specific areas of the brain. In this study, we ...
DOI:
10.1089/jmf.2021.0026

97. Preventive Effect of Apple Polyphenol Extract on High-Fat Diet-Induced Hepatic Steatosis in Mice through Alleviating Endoplasmic Reticulum Stress

Author:
Bei Yan; Lei Chen; Yanhui Wang; Jiacheng Zhang; Hui Zhao; Qinglian Hua; Shengjie Pei; Zihang Yue; Hui Liang; Huaqi Zhang
Source:
Journal of agricultural and food chemistry 2022 v.70 no.10 pp. 3172-3180
ISSN:
1520-5118
Subject:
Western blotting; apples; blood serum; body weight changes; endoplasmic reticulum stress; eosin; epididymis; fatty liver; food chemistry; high fat diet; histopathology; lipids; liver; lovastatin; polyphenols; protective effect
Abstract:
... In this work, the protective effect of apple polyphenol extract (APE) on hepatic steatosis was investigated. Thirty-two C57BL/6J mice were assigned randomly to control group, hepatic steatosis group, lovastatin group, and APE group. After 8 weeks of intervention, APE supplementation markedly decreased the body weight gain, liver weight, liver index, epididymal adipose weight, epididymal adipose in ...
DOI:
10.1021/acs.jafc.1c07733

98. Preventive Effects of Sesamol on Deep‐Frying Oil‐Induced Liver Metabolism Disorders by Altering Gut Microbiota and Protecting Gut Barrier Integrity

Author:
Lei Wang; Weixuan Chen; Yujie Tian; Xiaorong Duan; Yi Yuan; Na Wang; Chao Xu; Xuebo Liu; Zhigang Liu
Source:
Molecular nutrition & food research 2022 v.66 no.9 pp. e2101122
ISSN:
1613-4125
Subject:
Bifidobacterium; absorption barrier; antioxidant enzymes; colon; cooking fats and oils; deep fat frying; dysbiosis; food research; fried foods; high fat diet; homeostasis; intestinal microorganisms; jejunum; lipid metabolism; lipids; liver; obesity; soybean oil
Abstract:
... SCOPE: The total polar components (TPC) in the edible oil are produced during the frying process, and excessive intake of TPC may lead to metabolic disorders. This study aims to investigate the preventive effects of sesamol, a functional component from sesame, on suppressing TPC production, and on the deep‐frying oil (DFO)‐induced liver lipid metabolism disorders and gut homeostasis disruption. ME ...
DOI:
10.1002/mnfr.202101122

99. Preventive Impact of Long-Term Ingestion of Chestnut Honey on Glucose Disorders and Neurodegeneration in Obese Mice

Author:
Simona Terzo; Pasquale Calvi; Domenico Nuzzo; Pasquale Picone; Giacoma Galizzi; Luca Caruana; Marta Di Carlo; Laura Lentini; Roberto Puleio; Flavia Mulè; Antonella Amato
Source:
Nutrients 2022 v.14 no.4 pp. -
ISSN:
2072-6643
Subject:
adiponectin; apoptosis; blood lipids; cerebral cortex; chestnut honey; glucose; glucose tolerance; high fat diet; histology; ingestion; insulin; insulin resistance; leptin; lipid content; lipogenesis; metabolic diseases; mice; neurodegenerative diseases; neurons
Abstract:
... The purpose of the present study was to evaluate the impact of long-term honey ingestion on metabolic disorders and neurodegeneration in mice fed a high-fat diet (HFD). Three groups of mice were fed with a standard diet (STD), HFD or HFD supplemented with honey (HFD-H) for 16 weeks. Biochemical, histological, Western blotting, RT-PCR and Profiler PCR array were performed to assess metabolic parame ...
DOI:
10.3390/nu14040756

100. Proanthocyanidins from Chinese bayberry leaves reduce obesity and associated metabolic disorders in high-fat diet-induced obese mice through a combination of AMPK activation and an alteration in gut microbiota

Author:
Yu Zhang; Haibo Pan; Xingqian Ye; Shiguo Chen
Source:
Food & function 2022 v.13 no.4 pp. 2295-2305
ISSN:
2042-650X
Subject:
AMP-activated protein kinase; Clostridiaceae; Desulfovibrio; Morella rubra; Peptococcaceae; absorption barrier; antibiotics; dysbiosis; endotoxins; energy metabolism; high fat diet; inflammation; intestinal microorganisms; lipogenesis; liver; obesity; proanthocyanidins; white adipose tissue
Abstract:
... Regulating host energy metabolism and re-shaping gut microbiota are effective strategies against high-fat diet (HFD)-induced obesity and related metabolic disorders. A special type of proanthocyanidin extracted from Chinese bayberry leaves (BLPs) was studied for its effects and mechanisms in preventing HFD-induced obesity in mice. BLPs significantly reduced body weight, ameliorated inflammation an ...
DOI:
10.1039/d1fo04147a