U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject term high fat diet Remove constraint Subject term: high fat diet
Start Over

Search

7,529  Search Results

« Previous | 1 - 20 of 7,529 |
Number of results to display per page

Search Results

1. A comparison between high carbohydrate and high lipid diets reception on the growth, feed utilization and glucose homeostasis of genetically improved farmed tilapia Oreochromis niloticus

Author:
Kang-Wei Wang; Jun-Xing Chen; Qin-Qin Liu; Xin Deng; Li Luo; Shi-Mei Lin; Yong-Jun Chen
Source:
Aquaculture reports 2022 v.24 pp. 101119
ISSN:
2352-5134
Subject:
Oreochromis niloticus; acetyl-CoA carboxylase; aquaculture; blood glucose; body weight; carboxy-lyases; dietary carbohydrate; energy density; fatty-acid synthase; feed conversion; gene expression; gluconeogenesis; glucose; glucose transporters; glucose-6-phosphatase; glycogen; glycogen (starch) synthase; glycogenesis; glycogenolysis; glycolysis; growth performance; high carbohydrate diet; high fat diet; homeostasis; hyperglycemia; lipids; lipogenesis; liver; protein efficiency ratio; protein subunits; proximate composition; satiety; starch
Abstract:
... This study was performed to compare the effects of high carbohydrate and high lipid diets reception on the growth, feed utilization and glucose homeostasis of genetically improved farmed tilapia Oreochromis niloticus. Three isonitrogenous (ca 30.2% protein) diets were formulated with different levels of starch and lipid: the control (CON, 24.2% starch and 6.57% lipid), high carbohydrate diet (HCD, ...
DOI:
10.1016/j.aqrep.2022.101119

2. A high-fat diet alters lipid accumulation and oxidative stress and reduces the disease resistance of overwintering hybrid yellow catfish (Pelteobagrus fulvidraco♀×P. vachelli♂)

Author:
Shuzhan Fei; Yu Xia; Zheng Chen; Cui Liu; Haokun Liu; Dong Han; Junyan Jin; Yunxia Yang; Xiaoming Zhu; Shouqi Xie
Source:
Aquaculture reports 2022 v.23 pp. 101043
ISSN:
2352-5134
Subject:
Pelteobagrus; Tachysurus fulvidraco; Toll-like receptor 2; aquaculture; body weight; cortisol; crude protein; dietary fat; disease resistance; fish; gene expression; high fat diet; hybrids; immune response; inflammation; interleukin-10; kidneys; lipid content; lipids; lipogenesis; lipolysis; liver; lysozyme; malondialdehyde; overwintering; oxidative stress; spleen; superoxide dismutase; survival rate; transcription (genetics)
Abstract:
... This study was carried out to investigate the influence of dietary lipid levels on the growth, immune response, and disease resistance of hybrid yellow catfish (Pelteobagrus fulvidraco♀×P. vachelli♂) during overwintering. Yellow catfish (initial body weight: 49.42 ± 1.33 g) were fed isonitrogenous diets (crude protein 40%) with three lipid levels (low lipid: 8.57%, medium lipid: 12.65%, and high l ...
DOI:
10.1016/j.aqrep.2022.101043

3. A ketogenic diet attenuates acute and chronic ischemic kidney injury and reduces markers of oxidative stress and inflammation

Author:
Pedro Rojas-Morales; Juan Carlos León-Contreras; Mónica Sánchez-Tapia; Alejandro Silva-Palacios; Agustina Cano-Martínez; Susana González-Reyes; Angélica Saraí Jiménez-Osorio; Rogelio Hernández-Pando; Horacio Osorio-Alonso; Laura Gabriela Sánchez-Lozada; Armando R. Tovar; José Pedraza-Chaverri; Edilia Tapia
Source:
Life sciences 2022 v.289 pp. 120227
ISSN:
0024-3205
Subject:
Western blotting; acetylation; antioxidants; blood flow; fibrosis; high fat diet; histology; inflammation; interleukin-6; ischemia; ketogenic diet; ketone bodies; kidneys; liver; nephroprotective effect; oxidative stress; therapeutics
Abstract:
... Ischemic kidney injury is a common clinical condition resulting from transient interruption of the kidney's normal blood flow, leading to oxidative stress, inflammation, and kidney dysfunction. The ketogenic diet (KD), a low-carbohydrate, high-fat diet that stimulates endogenous ketone body production, has potent antioxidant and anti-inflammatory effects in distinct tissues and might thus protect ...
DOI:
10.1016/j.lfs.2021.120227

4. A network pharmacology-based strategy to explore the pharmacological mechanisms of Antrodia camphorata and antcin K for treating type II diabetes mellitus

Author:
Yi Kuang; Yue Chai; Huifei Su; Jen-Yu Lo; Xue Qiao; Min Ye
Source:
Phytomedicine 2022 v.96 pp. 153851
ISSN:
0944-7113
Subject:
Taiwanofungus camphoratus; adiponectin; blood serum; carbohydrate metabolism; fungi; glucose; glucose tolerance tests; high fat diet; insulin; insulin resistance; interleukin-6; leptin; mortality; pharmacology; quality of life
Abstract:
... Diabetes mellitus is a chronic carbohydrate metabolism disorder, which could develop a series of complications and thus lead to poor quality of life or even mortality. Antrodia camphorata is a rare parasitic fungus and has been proven to be effective for treating type II diabetes.This study aims to evaluate the anti-diabetic activities of A. camphorata and its main compound antcin K, as well as to ...
DOI:
10.1016/j.phymed.2021.153851

5. A polysaccharide from Rosa roxburghii Tratt fruit attenuates high-fat diet-induced intestinal barrier dysfunction and inflammation in mice by modulating the gut microbiota

Author:
Lei Wang; Pan Zhang; Chao Li; Fei Xu; Jie Chen
Source:
Food & function 2022 v.13 no.2 pp. 530-547
ISSN:
2042-650X
Subject:
Bacteroidetes; Rosa roxburghii; Ruminococcaceae; anti-inflammatory agents; blood serum; colitis; colorectal neoplasms; cytokines; diabetes; dysbiosis; fruits; high fat diet; inflammation; intestinal microorganisms; intestines; lactic acid; lipopolysaccharides; occludins; oxidative stress; permeability; tight junctions
Abstract:
... Obesity-induced colonic inflammation-stimulated colitis is one of the main causes of colorectal cancer. Dietary polysaccharides are considered an effective agent for relieving obesity-induced inflammatory diseases such as diabetes and colitis. In this work, the protective effects of a polysaccharide (RTFP) extracted from Rosa roxburghii Tratt fruit on barrier dysfunction and inflammation were inve ...
DOI:
10.1039/d1fo03190b

6. A polysaccharide isolated from Ganoderma lucidum ameliorates hyperglycemia through modulating gut microbiota in type 2 diabetic mice

Author:
Weiming Shao; Chun Xiao; Tianqiao Yong; Yifan Zhang; Huiping Hu; Ting Xie; Rongjie Liu; Longhua Huang; Xiangmin Li; Yizhen Xie; Jumei Zhang; Shaodan Chen; Manjun Cai; Diling Chen; Yuanchao Liu; Xiong Gao; Qingping Wu
Source:
International journal of biological macromolecules 2022 v.197 pp. 23-38
ISSN:
0141-8130
Subject:
Bacteroides; Ganoderma lucidum; Lactobacillus; Ruminococcaceae; blood glucose; endotoxins; fermentation; genes; glucose; glycogen; high fat diet; hyperglycemia; inflammation; insulin; insulin resistance; insulin secretion; intestinal microorganisms; intestines; liver; noninsulin-dependent diabetes mellitus; streptozotocin
Abstract:
... In this study, we reported a thermal stable and non-toxic heteropolysaccharide F31, which decreased the blood glucose of diabetic mice (21.75 mmol/L) induced by high-fat diet (HFD) and streptozotocin (STZ) to 12.56 and 15.18 mmol/L (P < 0.01) at 180 and 60 mg/kg, depicting remarkable hypoglycemic effects of 42.25 and 30.21%. Moreover, F31 repaired islet cells and increased insulin secretion, promo ...
DOI:
10.1016/j.ijbiomac.2021.12.034

7. Abnormal histidine metabolism promotes macrophage lipid accumulation under Ox-LDL condition

Author:
Baoling Zhu; Zhiwei Zhang; Xiangfei Wang; Weiwei Zhang; Hongyu Shi; Zhifeng Song; Suling Ding; Xiangdong Yang
Source:
Biochemical and biophysical research communications 2022 v.588 pp. 161-167
ISSN:
0006-291X
Subject:
antagonists; cholesterol; esterification; fat intake; genes; high fat diet; histamine; histidine; histidine decarboxylase; hydrolases; lipid metabolism; low density lipoprotein; macrophages; metabolic diseases; microarray technology; models; oxidation; oxidative stress; research
Abstract:
... Distinct macrophage populations exert highly heterogeneity and perform various functions, among which, a crucial function of lipid metabolism is highlighted. However, the role of histidine metabolism disorder in macrophage lipid metabolism remains elusive. Addressed this question, we sorted and cultured the bone marrow-derived macrophages (BMDMs) of histidine decarboxylase (Hdc) knockout (Hdc⁻/⁻) ...
DOI:
10.1016/j.bbrc.2021.12.069

8. Altered Mitochondrial Quality Control in Rats with Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD) Induced by High-Fat Feeding

Author:
Federica Cioffi; Antonia Giacco; Giuseppe Petito; Rita de Matteis; Rosalba Senese; Assunta Lombardi; Pieter de Lange; Maria Moreno; Fernando Goglia; Antonia Lanni; Elena Silvestri
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
animal models; biogenesis; chronic exposure; fatty liver; high fat diet; humans; mitochondria; mitochondrial DNA; mitophagy; noninsulin-dependent diabetes mellitus; obesity; quality control; rats; reactive oxygen species; temperature
Abstract:
... Metabolic dysfunction-associated fatty liver disease (MAFLD) is defined as the presence of hepatic steatosis in addition to one of three metabolic conditions: overweight/obesity, type 2 diabetes mellitus, or metabolic dysregulation. Chronic exposure to excess dietary fatty acids may cause hepatic steatosis and metabolic disturbances. The alteration of the quality of mitochondria is one of the fact ...
DOI:
10.3390/genes13020315

9. Angiopoietin-like protein 4 promotes hyperlipidemia-induced renal injury by down-regulating the expression of ACTN4

Author:
Yue Li; Wangqiu Gong; Jing Liu; Xingxing Chen; Yanhong Suo; Huabing Yang; Xia Gao
Source:
Biochemical and biophysical research communications 2022 v.595 pp. 69-75
ISSN:
0006-291X
Subject:
albumins; blood; blood lipids; genes; high fat diet; hyperlipidemia; kidneys; lipid metabolism; proteinuria; research
Abstract:
... The molecular mechanism of in hyperlipidemia-induced renal injury has not been elucidated. Angiogenin-like protein 4 (ANGPTL4) is a key regulator of lipid metabolism. The role of ANGPTL4 hyperlipidemia-induced renal injury has not been reported. Wild type C57 mice and gene angptl4 knockout mice were fed with 60% high fat diet or normal diet respectively. The serum lipid, urinary albumin and renal ...
DOI:
10.1016/j.bbrc.2022.01.061

10. Anti-Obesity Effects of Ecklonia cava Extract in High-Fat Diet-Induced Obese Rats

Author:
Muhammad Aleem Abbas; Naila Boby; Eon-Bee Lee; Joo-Heon Hong; Seung-Chun Park
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
Ecklonia; adipose tissue; anti-obesity effects; biomarkers; dose response; epididymis; ethanol; fatty liver; food intake; high energy foods; high fat diet; liver; obesity; tissue weight
Abstract:
... Obesity is becoming a global epidemic as a result of high-calorie food intake and unhealthy lifestyles. Different marine plants, especially brown algae (Ecklonia cava), are traditionally used to treat different health-related issues. The study was carried out to investigate the anti-obesity properties of E. cava 70% ethanol extract. To evaluate the anti-obesity effect of E. cava, both in vitro and ...
DOI:
10.3390/antiox11020310

11. Anti-hyperglycemic, anti-hyperlipidemic, and anti-inflammatory effect of the drug Guggulutiktaka ghrita on high-fat diet-induced obese rats

Author:
Samreen M. Sheik; Pugazhandhi Bakthavatchalam; Revathi P. Shenoy; Basavaraj S. Hadapad; Deepak Nayak M; Monalisa Biswas; B.S. Varashree
Source:
Journal of Ayurveda and integrative medicine 2022 pp. 100583
ISSN:
0975-9476
Subject:
Ayurvedic medicine; anti-inflammatory activity; blood glucose; blood lipids; blood serum; cardiovascular diseases; drugs; glycemic effect; heart; high fat diet; histopathology; hyperglycemia; hyperlipidemia; inflammation; lipid composition; liver; vascular cell adhesion molecules
Abstract:
... Ayurveda is a holistic system of medicine and describes a vast array of herbs and herbal mixtures that are been demonstrated to possess efficacy in research investigations. Guggulutikthaka gritha (GTG) is one such drug evaluated for its role in skin and bone disease. In the current study, the hypoglycemic, hypolipidemic, and anti-inflammatory effect of the drug GTG was studied with the scope to tr ...
DOI:
10.1016/j.jaim.2022.100583

12. Anti-obesity effect of Cydonia oblonga Miller extract in high-fat diet-induced obese C57BL/6 mice

Author:
Hyun Sook Lee; Young Eun Jeon; Jae In Jung; So Mi Kim; Su Hee Hong; Jaehak Lee; Jung Soon Hwang; Myeong Oh Hwang; Kisung Kwon; Eun Ji Kim
Source:
Journal of functional foods 2022 v.89 pp. 104945
ISSN:
1756-4646
Subject:
ATP citrate synthase; Cydonia oblonga; acetyl-CoA carboxylase; adipocytes; adipogenesis; adiponectin; adipose tissue; anti-obesity agents; anti-obesity effects; beta oxidation; blood serum; carboxylic ester hydrolases; carnitine palmitoyltransferase; fatty-acid synthase; gene expression; high fat diet; insulin; leptin; lipolysis; obesity; tissue weight; triacylglycerols
Abstract:
... The present study was designed to explore whether Cydonia oblonga Miller extract (COME) had anti-obesity effects and the mechanism involved. COME reduced body weight, fat mass, adipose tissue weight, and serum levels of insulin, triglyceride, and leptin, but increased the serum levels of adiponectin and high-density lipoprotein-cholesterol in high-fat diet (HFD)-induced obese C57BL/6 mice. COME in ...
DOI:
10.1016/j.jff.2022.104945

13. Antiatherosclerotic effects of corilagin via suppression of the LOX-1/MyD88/NF-κB signaling pathway in vivo and in vitro

Author:
Bo He; Deyun Chen; Xiaochao Zhang; Renhua Yang; Yuan Yang; Peng Chen; Zhiqiang Shen
Source:
Natural medicines 2022 v.76 no.2 pp. 389-401
ISSN:
1340-3443
Subject:
Phyllanthus urinaria; aorta; atherosclerosis; blood lipids; blood serum; chemokine CCL2; colorimetry; foams; glycemic effect; high fat diet; histology; polyphenols; protein synthesis; rabbits; reverse transcriptase polymerase chain reaction; smooth muscle; transcription factor NF-kappa B
Abstract:
... Corilagin, a natural polyphenol compound isolated from Phyllanthus urinaria L., exerts various pharmacological effects, such as antihyperglycemic, antitumor, and antioxidative stress properties, but the mechanisms underlying the antiatherosclerotic effects of corilagin have not been entirely elucidated. In the present study, we investigated the antiatherosclerotic effects of corilagin using a high ...
DOI:
10.1007/s11418-021-01594-y

14. Antidiabetic Effects of Pediococcus acidilactici pA1c on HFD-Induced Mice

Author:
Miriam Cabello-Olmo; María Oneca; María José Pajares; Maddalen Jiménez; Josune Ayo; Ignacio J. Encío; Miguel Barajas; Miriam Araña
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
Pediococcus acidilactici; animal models; blood glucose; body weight changes; c-peptide; disease progression; gene expression; glucagon-like peptide 1; glucose; glucose tolerance; glucose tolerance tests; high fat diet; histology; insulin resistance; interleukin-6; intestinal microorganisms; intestines; leptin; lipid composition; noninsulin-dependent diabetes mellitus; placebos; probiotics; risk factors; villi
Abstract:
... Prediabetes (PreD), which is associated with impaired glucose tolerance and fasting blood glucose, is a potential risk factor for type 2 diabetes mellitus (T2D). Growing evidence suggests the role of the gastrointestinal microbiota in both PreD and T2D, which opens the possibility for a novel nutritional approach, based on probiotics, for improving glucose regulation and delaying disease progressi ...
DOI:
10.3390/nu14030692

15. Antidiabetic effects of multi-species probiotic and its fermented milk in mice via restoring gut microbiota and intestinal barrier

Author:
Yuxiang Gu; Xing Li; Haoran Chen; Yue Sun; Lin Yang; Ying Ma; Eric Chun Yong Chan
Source:
Food bioscience 2022 v.47 pp. 101619
ISSN:
2212-4292
Subject:
Bifidobacterium animalis subsp. lactis; Lactobacillus acidophilus; Lactobacillus rhamnosus; Streptococcus thermophilus; blood glucose; body weight changes; fermentation; glucose tolerance; high fat diet; insulin; insulin resistance; intestinal microorganisms; intestines; lipids; noninsulin-dependent diabetes mellitus; nutritional intervention; permeability; probiotics; remission; streptozotocin; tissue weight; yogurt
Abstract:
... Probiotic is a promising nutritional intervention for the prevention and alleviation of type 2 diabetes (T2DM). In this study, the remission potential of a multi-species probiotic (Lactobacillus acidophilus NCFM, Lactobacillus rhamnosus GG, Bifidobacterium lactis HN019 and Streptococcus thermophilus ST447) and its fermented yoghurt on the symptoms of high fat diet and streptozotocin induced T2DM m ...
DOI:
10.1016/j.fbio.2022.101619

16. Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity

Author:
Yi-ni Cao; Shan-shan Yue; An-yi Wang; Lu Xu; Yi-tong Hu; Xue Qiao; Tung-Ying Wu; Min Ye; Yang-Chang Wu; Rong Qi
Source:
Journal of ethnopharmacology 2022 v.292 pp. 115146
ISSN:
0378-8741
Subject:
Lentivirus; Taiwanofungus camphoratus; active ingredients; aldehyde dehydrogenase; aldehydes; blood serum; body weight; dose response; drug therapy; fatty liver; hepatocytes; high fat diet; inflammation; lipogenesis; liver; medicinal fungi; mice; mitochondria; oleic acid; oxidative stress; traditional medicine; triacylglycerols
Abstract:
... Nonalcoholic fatty liver disease (NAFLD) is a prevalent liver disease, but currently has no specific medication in clinic. Antrodia cinnamomea (AC) is a medicinal fungus and it has been shown that AC can inhibit high fat diet (HFD)-induced lipid deposition in mouse livers, but the effective monomer in AC and mechanism against NAFLD remain unclear. It has been reported that aldehyde dehydrogenase 2 ...
DOI:
10.1016/j.jep.2022.115146

17. Apple polyphenol extract modulates bile acid metabolism and gut microbiota by regulating the circadian rhythms in daytime-restricted high fat diet feeding C57BL/6 male mice

Author:
Yuan Cui; Yan Yin; Shilan Li; Zhengli Wu; Yisha Xie; Qingfan Qian; Hao Yang; Xinli Li
Source:
Food & function 2022 v.13 no.5 pp. 2805-2822
ISSN:
2042-650X
Subject:
apples; bile acids; body weight; circadian clocks; health status; high fat diet; homeostasis; ileum; intestinal microorganisms; males; metabolism; polyphenols; probiotics
Abstract:
... The homeostasis of circadian clock linked to bile acid (BA) metabolism and gut microbiota has profound benefits in maintaining the health status of the host. The aim of this study was to investigate the prevention and regulation of apple polyphenol extract (APE) on BA metabolism and gut microbiota by means of modulation of circadian rhythms in mice. Eighty male C57BL/6 mice were randomized into fo ...
DOI:
10.1039/d1fo04116a

18. Astilbin from Smilax glabra Roxb. alleviates high-fat diet-induced metabolic dysfunction

Author:
Tingwei Wang; Yongli Ye; Jian Ji; Shuang Zhang; Xingxing Yang; Jiayuan Xu; Jia-Sheng Wang; Zhiyuan Chen; Bangen Xia; Hongfang Shen; Ruowei Xia; Wenqin Shi; Xiulan Sun
Source:
Food & function 2022 v.13 no.9 pp. 5023-5036
ISSN:
2042-650X
Subject:
Coriobacteriaceae; Lachnospiraceae; Ruminococcaceae; Smilax glabra; adipocytes; adipogenesis; anti-inflammatory activity; carbohydrates; droplets; dysbiosis; endotoxemia; glutamic acid; hepatoprotective effect; high fat diet; inflammation; insulin resistance; intestinal microorganisms; intestines; lipid metabolism; multiomics; obesity; prebiotics; public health; rhizomes; short chain fatty acids; triacylglycerols; xanthine
Abstract:
... Overweight, obesity, and related diseases are currently the major public health problems worldwide. Astilbin, extracted from the rhizome of Smilax glabra Roxb., is known to have significant anti-inflammatory activity and hepatoprotective effect. Studies have shown that it can inhibit adipogenesis in adipocytes in vitro; however, the intervention benefits of astilbin against obesity and related dis ...
DOI:
10.1039/d2fo00060a

19. Beneficial effects of Ilex paraguariensis in the prevention of obesity‐associated metabolic disorders in mice

Author:
Helber da Maia Valença; Cyntia Pecli e Silva; Lycia de Brito Gitirana; Samuel Santos Valença; Manuella Lanzetti
Source:
Phytotherapy research 2022 v.36 no.2 pp. 1032-1042
ISSN:
0951-418X
Subject:
Ilex paraguariensis; adipocytes; adipose tissue; antioxidant activity; biomarkers; blood; dimethyl fumarate; fatty liver; glucose; heme oxygenase (biliverdin-producing); high density lipoprotein; high fat diet; histology; hypertrophy; inflammation; leptin; liver; obesity; oxidative stress; phytotherapy; quinones; research; resistin; superoxide dismutase
Abstract:
... Obesity is a chronic condition involving inflammation and oxidative stress that commonly predisposes affected individuals to develop metabolic disorders. We hypothesize that Ilex paraguariensis (IP) can modulate oxidative stress and inflammation underpinning metabolic disorders caused by obesity. C57BL/6 mice were fed a high‐fat diet (HFD group) for 12 weeks. Concomitantly, some mice were treated ...
DOI:
10.1002/ptr.7377

20. Beneficial effects of eicosapentaenoic acid on the metabolic profile of obese female mice entails upregulation of HEPEs and increased abundance of enteric Akkermansia muciniphila

Author:
Anandita Pal; Shan Sun; Michael Armstrong; Jonathan Manke; Nicole Reisdorph; Victoria R. Adams; Arion Kennedy; Yujiao Zu; Naima Moustaid-Moussa; Ian Carroll; Saame Raza Shaikh
Source:
Biochimica et biophysica acta 2022 v.1867 no.1 pp. 159059
ISSN:
1388-1981
Subject:
RNA; biosynthesis; cell culture; cell differentiation; eicosapentaenoic acid; females; genes; glucose; high fat diet; homeostasis; insulin; intestinal microorganisms; intestines; males; mass spectrometry; mice; risk
Abstract:
... Eicosapentaenoic acid (EPA) ethyl esters are of interest given their clinical approval for lowering circulating triglycerides and cardiometabolic disease risk. EPA ethyl esters prevent metabolic complications driven by a high fat diet in male mice; however, their impact on female mice is less studied. Herein, we first investigated how EPA influences the metabolic profile of female C57BL/6J mice co ...
DOI:
10.1016/j.bbalip.2021.159059