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- Reiter, Florian Paul, et al. Show all 8 Authors
- Biochemical and biophysical research communications 2012 v.424 no.4 pp. 758-764
- apoptosis; bile; caspases; cholelithiasis; cholestasis; cholesterol; cytosol; free fatty acids; hepatocytes; human cell lines; humans; hydrophilicity; immunoblotting; liver; membrane potential; mice; mitochondria; mitochondrial membrane; rats; ursodeoxycholic acid
- ... PURPOSE: β-Muricholic acid (βMCA) is a trihydroxylated bile acid that constitutes the major bile acid in rat and mouse. βMCA is more hydrophilic than ursodeoxycholic acid and has been evaluated for dissolution of cholesterol gallstones. Since it is unknown if βMCA has beneficial effects on hepatocyte cell death we determined the effect of tauro-βMCA (TβMCA) on apoptosis in vitro. METHODS: Human Nt ...