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You searched for: Subject term humans Remove constraint Subject term: humans Subject term animal injuries Remove constraint Subject term: animal injuries
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1. Recurrence of Spontaneous Lung Lobe Torsion in a Pug

Author:
Sprankin, David B.; Gulikers, Keven P.; Lanz, Otto I.
Source:
Journal of the American Animal Hospital Association 2003 v.39 no.5 pp. 446-451
ISSN:
0587-2871
Subject:
animal injuries; cats; dogs; hernia; humans; surgery
Abstract:
... Lung lobe torsion (LLT) results from a displacement and twisting of a lung lobe around its bronchovascular pedicle. This relatively rare disorder affects dogs, cats, and humans. Etiologies include primary (i.e., spontaneous) and secondary torsion due to thoracic trauma, pleural space disease, thoracic surgery, pulmonary parenchyma disease, and diaphragmatic hernia repair. Although both spontaneous ...
DOI:
10.5326/0390446
PubMed:
14518651

2. Detection of human neutrophil elastase with peptide-bound cross-linked ethoxylate acrylate resin analogs

Author:
Edwards, J.V.; Caston-Pierre, S.; Bopp, A.F.; Goynes, W.
Source:
Journal of peptide research 2005 v.66 no.4 pp. 160-168
ISSN:
1399-3011
Subject:
humans; elastase; neutrophils; assays; enzyme activity; resins; peptides; crosslinking; animal injuries
Abstract:
... An assessment of elastase-substrate kinetics and adsorption at the solid–liquid interface of peptide-bound resin was made in an approach to the solid-phase detection of human neutrophil elastase (HNE), which is found in high concentration in chronic wound fluid. N-succinyl-alanine-alanine-proline-valine-p-nitroanilide (suc-Ala-Ala-Pro-Val-pNA), a chromogenic HNE substrate, was attached to glycine- ...
Handle:
10113/40936
DOI:
10.1111/j.1399-3011.2005.00284.x
PubMed:
16138854

3. Inflammatory changes in ruptured canine cranial and human anterior cruciate ligaments

Author:
Barrett, J.G.; Hao, Z.; Graf, B.K.; Kaplan, L.D.; Heiner, J.P.; Muir, P.
Source:
American journal of veterinary research 2005 v.66 no.12 pp. 2073-2080
ISSN:
0002-9645
Subject:
elderly; animal injuries; tissue repair; acid phosphatase; humans; ligaments; dogs; macrophages; inflammation; stifle; cathepsins; enzyme activity; synovial fluid
DOI:
10.2460/ajvr.2005.66.2073
PubMed:
16379649

4. Animal sexual abuse: A veterinary taboo

Author:
Munro, H.M.C.
Source:
Veterinary journal 2006 v.172 no.2 pp. 195-197
ISSN:
1090-0233
Subject:
sexual behavior; bioethics; animal injuries; abnormal behavior; attitudes and opinions; humans; human-animal relations; animal well-being; veterinary medicine; violence; distress; veterinarians; sexual abuse
DOI:
10.1016/j.tvjl.2005.08.033
PubMed:
16246601

5. Correlates between human lung injury after particle exposure and recurrent airway obstruction in the horse

Author:
Ghio, A.J.; Mazan, M.R.; Hoffman, A.M.; Robinson, N.E.
Source:
Equine veterinary journal 2006 v.38 no.4 pp. 362-367
ISSN:
0425-1644
Subject:
horses; humans; respiratory tract diseases; animal injuries; horse diseases; human diseases; particulates; breathing; morbidity; mortality; inflammation; neutrophils
PubMed:
16866207

6. First documented Capnocytophaga canimorsus infection in a species other than humans

Author:
Duijkeren, E. van; Mourik, C. van; Broekhuizen, M.; Leuven, M.; Gaastra, W.; Houwers, D.
Source:
Veterinary microbiology 2006 v.118 no.1-2 pp. 148-150
ISSN:
0378-1135
Subject:
rabbits; pets; dogs; bites and stings; animal injuries; Capnocytophaga canimorsus; animal pathogenic bacteria; zoonoses; bacterial infections; rabbit diseases; host range; humans; case studies
Abstract:
... Capnocytophaga canimorsus was cultured from an infected, dog-inflicted bite wound in a pet rabbit. The wound was treated successfully and the rabbit recovered. To our knowledge, this is the first report of a C. canimorsus infection in a species other than humans. ...
DOI:
10.1016/j.vetmic.2006.07.002

7. Prevention of central sensitization and pain by N-methyl-D-aspartate receptor antagonists

Author:
Pozzi, A.; Muir, W.W. III; Traverso, F.
Source:
Journal of the American Veterinary Medical Association 2006 v.228 no.1 pp. 53-60
ISSN:
0003-1488
Subject:
analgesia; animal injuries; pain; aspartic acid; humans; antagonists; amino acid derivatives; peripheral nervous system; receptors
DOI:
10.2460/javma.228.1.53

8. Use of fish oil in parenteral nutrition: Rationale and reality

Author:
Calder, P.C.
Source:
Proceedings of the Nutrition Society 2006 v.65 no.3 pp. 264-277
ISSN:
0029-6651
Subject:
eicosanoids; transcription factors; septic shock; animal injuries; humans; immunosuppression; meta-analysis; inflammation; parenteral feeding; cytokines; arachidonic acid; surgery; omega-3 fatty acids; fish oils; dietary supplements; gene expression regulation; bacterial infections
Abstract:
... Excessive or inappropriate inflammation and immunosuppression are components of the response to surgery, trauma, injury and infection in some individuals and can lead, progressively, to sepsis and septic shock. The hyperinflammation is characterised by the production of inflammatory cytokines, arachidonic acid-derived eicosanoids and other inflammatory mediators, while the immunosuppression is cha ...
PubMed:
16923311

9. Risk factors for Thoroughbred racehorse fatality in flat starts in Victoria, Australia (1989-2004)

Author:
Boden, L.A.; Anderson, G.A.; Charles, J.A.; Morgan, K.L.; Morton, J.M.; Parkin, T.D.H.; Clarke, A.F.; Slocombe R.F.
Source:
Equine veterinary journal 2007 v.39 no.5 pp. 430-437
ISSN:
0425-1644
Subject:
racehorses; Thoroughbred; racing performance; mortality; risk factors; epidemiological studies; etiology; euthanasia; regression analysis; animal injuries; humans; Victoria (Australia)
PubMed:
17910268

10. Structural differentiation of skeletal muscle fibers in the absence of innervation in humans

Author:
Boncompagni, Simona; Kern, Helmut; Rossini, Katia; Hofer, Christian; Mayr, Winfried; Carraro, Ugo; Protasi, Feliciano
Source:
Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.49 pp. 19339-19344
ISSN:
0027-8424
Subject:
animal injuries; atrophy; biopsy; electrical treatment; electron microscopy; humans; innervation; muscles; myofibrils; neurotrophins; patients; spinal cord
Abstract:
... The relative importance of muscle activity versus neurotrophic factors in the maintenance of muscle differentiation has been greatly debated. Muscle biopsies from spinal cord injury patients, who were trained with an innovative protocol of functional electrical stimulation (FES) for prolonged periods (2.4-9.3 years), offered the unique opportunity of studying the structural recovery of denervated ...
DOI:
10.1073/pnas.0709061104
PubMed:
18042706
PubMed Central:
PMC2148291

11. Transplantation of canine umbilical cord blood-derived mesenchymal stem cells in experimentally induced spinal cord injured dogs

Author:
Lim, J.H.; Byeon, Y.E.; Ryu, H.H.; Jeong, Y.H.; Lee, Y.W.; Kim, W.H.; Kang, K.S.; Kweon, O.K.
Source:
Journal of veterinary science 2007 v.8 no.3 pp. 275-282
ISSN:
1229-845X
Subject:
animal injuries; humans; recombinant proteins; dogs; umbilical cord; medical treatment; cell transplantation; stem cells; granulocytes; spinal cord; colony-stimulating factors; animal disease models
DOI:
10.4142/jvs.2007.8.3.275
PubMed:
17679775
PubMed Central:
PMC2868135

12. Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly

Author:
Matthew J Hardman; Gillian S Ashcroft
Source:
Genome biology 2008 v.9 no.5 pp. 1942
ISSN:
1474-760X
Subject:
animal injuries; elderly; gene expression; genes; hormones; humans; males; mice; microarray technology; protein synthesis; tissue repair
Abstract:
... BACKGROUND: Multiple processes have been implicated in age-related delayed healing, including altered gene expression, intrinsic cellular changes, and changes in extracellular milieu (including hormones). To date, little attempt has been made to assess the relative contribution of each of these processes to a human aging phenomenon. The objective of this study is to determine the contribution of e ...
DOI:
10.1186/gb-2008-9-5-r80
PubMed:
18477406
PubMed Central:
PMC2441466

13. Human ApoD, an apolipoprotein up-regulated in neurodegenerative diseases, extends lifespan and increases stress resistance in Drosophila

Author:
Muffat, Julien; Walker, David W.; Benzer, Seymour
Source:
Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.19 pp. 7088-7093
ISSN:
0027-8424
Subject:
Alzheimer disease; Drosophila; Parkinson disease; animal injuries; apolipoprotein D; heat stress; humans; hyperoxia; imagos; lipid peroxidation; longevity; mechanism of action; mice; models; oxidative stress; paraquat; spinal cord; stress response; stress tolerance
Abstract:
... Apolipoprotein D (ApoD) expression increases in several neurological disorders and in spinal cord injury. We provide a report of a physiological role for human ApoD (hApoD): Flies overexpressing hApoD are long-lived and protected against stress conditions associated with aging and neurodegeneration, including hyperoxia, dietary paraquat, and heat stress. We show that the fly ortholog, Glial Lazari ...
DOI:
10.1073/pnas.0800896105
PubMed:
18458334
PubMed Central:
PMC2374552

14. Not the Usual Suspects: Human Wound Myiasis by Phorids

Author:
Huntington, T.E.; Voigt, D.W.; Higley, L.G.
Source:
Journal of medical entomology 2008 v.45 no.1 pp. 157-159
ISSN:
0022-2585
Subject:
humans; myiasis; Phoridae; larvae; animal injuries; medical entomology; Nebraska
Abstract:
... Infestation of animal tissues by dipteran larvae (myiasis) commonly occurs in many species, but it is unusual for humans in temperate regions. Nevertheless, human myiasis is regularly observed in many primary care facilities in the United States. Beyond medical issues associated with treating human myiasis, both the causal agent and the longevity of myiasis can have legal implications, for example ...
DOI:
10.1603/0022-2585(2008)45[157:NTUSHW]2.0.CO;2
PubMed:
18283957

15. Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

Author:
Krüger, Bernd; Krick, Stefanie; Dhillon, Navdeep; Lerner, Susan M.; Ames, Scott; Bromberg, Jonathan S.; Lin, Marvin; Walsh, Liron; Vella, John; Fischereder, Michael; Krämer, Bernhard K.; Colvin, Robert B.; Heeger, Peter S.; Murphy, Barbara T.; Schröppel, Bernd
Source:
Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.9 pp. 3390-3395
ISSN:
0027-8424
Subject:
Toll-like receptor 4; alleles; allografting; animal injuries; animal models; cold; gene expression; heme oxygenase (biliverdin-producing); humans; inflammation; ischemia; kidney transplant; kidneys; loss-of-function mutation; nucleoproteins; tumor necrosis factor-alpha
Abstract:
... While studies in animal models have linked Toll-like receptor (TLR) 4 signaling to kidney injury induced by ischemia and reperfusion, the relevance of TLR4 activation to allograft injury in human kidney transplants is unknown. Here we show that TLR4 is constitutively expressed within all donor kidneys but is significantly higher in deceased-, compared with living-donor organs. Tubules from decease ...
DOI:
10.1073/pnas.0810169106
PubMed:
19218437
PubMed Central:
PMC2651292

16. Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

Author:
Peng, Weiguo; Cotrina, Maria L.; Han, Xiaoning; Yu, Hongmei; Bekar, Lane; Blum, Livnat; Takano, Takahiro; Tian, Guo-Feng; Goldman, Steven A.; Nedergaard, Maiken
Source:
Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.30 pp. 12489-12493
ISSN:
0027-8424
Subject:
adenosine triphosphate; animal injuries; antagonists; astrocytes; blood-brain barrier; color; humans; inflammation; models; neurons; neuroprotective effect; neutrophils; patients; rats; receptors; spinal cord; toxicity
Abstract:
... Traumatic spinal cord injury is characterized by an immediate, irreversible loss of tissue at the lesion site, as well as a secondary expansion of tissue damage over time. Although secondary injury should, in principle, be preventable, no effective treatment options currently exist for patients with acute spinal cord injury (SCI). Excessive release of ATP by the traumatized tissue, followed by act ...
DOI:
10.1073/pnas.0902531106
PubMed:
19666625
PubMed Central:
PMC2718350

17. An Accidental But Safe and Effective use of Lucilia cuprina (Diptera: Calliphoridae) in Maggot Debridement Therapy in Alexandria, Egypt

Author:
Tantawi, Tarek I.; Williams, Kirstin A.; Villet, Martin H.
Source:
Journal of medical entomology 2010 v.47 no.3 pp. 491-494
ISSN:
0022-2585
Subject:
insect morphology; animal injuries; tissue repair; humans; hospitals; debridement; meat carcasses; quality control; nucleotide sequences; patients; imagos; larvae; Lucilia cuprina; insect rearing; feet; Egypt
Abstract:
... The calliphorid fly, Lucilia cuprina (Wiedemann), is known to cause serious malign myiasis in animals, whereas its sibling species Lucilia sericata (Meigen) is commonly a carrion breeder and is used in maggot debridement therapy (MDT). The current study reports an accidental involvement of L. cuprina in MDT in Alexandria, Egypt, that has proved to be safe and effective. In November 2008, the labor ...
DOI:
10.1603/ME09183
PubMed:
20496600

18. Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence

Author:
Kaneiwa, Tomoyuki; Mizumoto, Shuji; Sugahara, Kazuyuki; Yamada, Shuhei
Source:
Glycobiology 2010 v.20 no.3 pp. 300-309
ISSN:
0959-6658
Subject:
Caenorhabditis elegans; animal injuries; cartilage; chondroitin sulfate; clinical trials; glucuronic acid; glycosidases; humans; hyaluronic acid; metabolism; sharks; spinal cord
Abstract:
... Human hyaluronidases have been considered to be the enzymes acting at the initial step in the catabolism of chondroitin sulfate (CS) in vivo. However, human hyaluronidase-1 digests CS more slowly than hyaluronan (HA), and its preferred substrate is HA rather than CS. We have identified a chondroitin hydrolase in Caenorhabditis elegans, which effectively degrades chondroitin but depolymerizes HA to ...
DOI:
10.1093/glycob/cwp174

19. Imaging and clinical judgement

Author:
Dandy, D.
Source:
Equine veterinary journal 2010 v.42 no.4 pp. 287
ISSN:
0425-1644
Subject:
magnetic resonance imaging; image analysis; computed tomography; ultrasonography; radiography; horses; humans; knees; animal injuries; pain; medical history; disease diagnosis
DOI:
10.1111/j.2042-3306.2010.00083.x
PubMed:
20525044

20. Repeatability of lameness, fear and slipping scores to assess animal welfare upon arrival in pig slaughterhouses

Author:
Dalmau, A.; Geverink, N.A.; Nuffel, A. van; Steenbergen, L. van; Reenen, K. Van; Hautekiet, V.; Vermeulen, K.; Velarde, A.; Tuyttens, F.A.M.
Source:
Animal 2010 v.4 no.5 pp. 804-809
ISSN:
1751-7311
Subject:
animal well-being; validity; European Union; vocalization; repeatability; measurement; slaughter; livestock production; biomarkers; slaughterhouses; monitoring; humans; lameness; accuracy; swine; animal injuries; escape behavior; fearfulness; reference standards; Europe
Abstract:
... The EU project Welfare Quality® proposes an overall assessment system for animal welfare based on animal outcomes. The objective of this study was to test inter-observer reliability (IOR) when assessing lameness, fear and slipping and falling scores as parameters for monitoring the welfare of killing pigs during arrival at the slaughterhouse. Two Belgian and two Spanish slaughterhouses were visite ...
DOI:
10.1017/S1751731110000066
PubMed:
22444137

21. Traumatic brain injury: a review of pathophysiology and management

Author:
Sande, Allison; West, Chad
Source:
Journal of veterinary emergency and critical care 2010 v.20 no.2 pp. 177-190
ISSN:
1479-3261
Subject:
pathophysiology; animal injuries; image analysis; humans; accidents; cats; dogs; brain; guidelines; therapeutics; head; mechanical damage; cardiovascular system; patients; pets; clinical examination; veterinarians; mortality
Abstract:
... To review current information regarding the pathophysiology associated with traumatic brain injury (TBI), and to outline appropriate patient assessment, diagnostic, and therapeutic options. TBI in veterinary patients can occur subsequent to trauma induced by motor vehicle accidents, falls, and crush injuries. Primary brain injury occurs at the time of initial impact as a result of direct mechanica ...
DOI:
10.1111/j.1476-4431.2010.00527.x
PubMed:
20487246

22. Bio-logic analysis of injury biomarker patterns in human serum samples

Author:
Jian Zhou; Jan Halámek; Vera Bocharova; Joseph Wang; Evgeny Katz
Source:
Talanta 2011 v.83 no.3 pp. 955-959
ISSN:
0039-9140
Subject:
animal injuries; bioassays; biomarkers; biosensors; blood serum; humans; liver
Abstract:
... Digital biosensor systems analyzing biomarkers characteristic of liver injury (LI), soft tissue injury (STI) and abdominal trauma (ABT) were developed and optimized for their performance in serum solutions spiked with injury biomarkers in order to mimic real medical samples. The systems produced ‘Alert’-type optical output signals in the form of “YES-NO” separated by a threshold value. The new app ...
DOI:
10.1016/j.talanta.2010.10.057
PubMed:
21147343

23. Increased hypoglycemia associated with renal failure during continuous intravenous insulin infusion and specialized nutritional support

Author:
Roland N. Dickerson; Leslie A. Hamilton; Kathryn A. Connor; George O. Maish III; Martin A. Croce; Gayle Minard; Rex O. Brown
Source:
Nutrition 2011 v.27 no.7-8 pp. 766-772
ISSN:
0899-9007
Subject:
adults; algorithms; animal injuries; blood glucose; enteral feeding; glycemic control; history; humans; hypoglycemia; insulin; intravenous injection; parenteral feeding; patients; renal failure; risk
Abstract:
... OBJECTIVE: To evaluate glycemic control for critically ill, hyperglycemic trauma patients with renal failure who received concurrent intensive insulin therapy and continuous enteral nutrition (EN) or parenteral nutrition (PN). METHODS: Adult trauma patients with renal failure who were given EN or PN concurrently with continuous graduated intravenous regular human insulin (RHI) infusion for at leas ...
DOI:
10.1016/j.nut.2010.08.009
PubMed:
20971617

24. Rodent laparoscopy: Refinement for rodent drug studies and model development, and monitoring of neoplastic, inflammatory and metabolic diseases

Author:
Szczepan W Baran; Marcel I Perret-Gentil; Elizabeth J Johnson; Emily L Miedel; James Kehler
Source:
Laboratory animals 2011 v.45 no.4 pp. 231-239
ISSN:
1758-1117
Subject:
euthanasia; disease models; animal injuries; pain; equipment; humans; disease surveillance; drugs; morbidity; instrumentation; data collection; neoplasms; preserves; laparoscopy; metabolic diseases; laparotomy; biopsy; rodents; mortality; disease course
Abstract:
... The refinement of surgical techniques represents a key opportunity to improve the welfare of laboratory rodents, while meeting legal and ethical obligations. Current methods used for monitoring intra-abdominal disease progression in rodents usually involve euthanasia at various time-points for end of study, one-time individual tissue collections. Most rodent organ tumour models are developed by th ...
DOI:
10.1258/la.2011.010027

25. The enhancement of endothelial cell therapy for angiogenesis in hindlimb ischemia using hyaluronan

Author:
Zack C.W. Tang; Wei-Yin Liao; Alan C.L. Tang; Shih-Jung Tsai; Patrick C.H. Hsieh
Source:
Biomaterials 2011 v.32 no.1 pp. 75-86
ISSN:
0142-9612
Subject:
angiogenesis; animal injuries; animal models; apoptosis; arteries; blood; cell culture; cell growth; cell transplantation; endothelial cells; hindlimbs; humans; hyaluronic acid; immunocompromised population; injection; ischemia; mice; umbilical veins; vascular diseases
Abstract:
... Growing evidence shows that injection of hyaluronan (HA) benefits ischemic injury in animals. On the other hand, cell therapy is an emerging approach to treat occlusive arterial diseases, although the low retention rate of cells after direct injection remains a major concern. Here, we tested whether injection of HA along with endothelial cells promotes the retention and growth of transplanted cell ...
DOI:
10.1016/j.biomaterials.2010.08.085
PubMed:
20889204

26. The use of a gold nanoparticle-based adjuvant to improve the therapeutic efficacy of hNgR-Fc protein immunization in spinal cord-injured rats

Author:
Yong-Tang Wang; Xiu-Min Lu; Feng Zhu; Peng Huang; Ying Yu; Lin Zeng; Zai-Yun Long; Ya-Min Wu
Source:
Biomaterials 2011 v.32 no.31 pp. 7988-7998
ISSN:
0142-9612
Subject:
adults; adverse effects; animal injuries; antibodies; antiserum; gold; humans; immune response; models; myelin sheath; nanogold; neuroprotective effect; rats; recombinant proteins; spinal cord; toxicity; uncertainty; vaccination; vaccines
Abstract:
... As a common receptor for three myelin associated inhibitors, Nogo-66 receptor (NgR) mediates their inhibitory activities on neurite outgrowth in the adult mammalian central nervous system (CNS). Therapeutic vaccination protocol targeting NgR emulsified with Freund’s adjuvant (FA) has been used in spinal cord injury (SCI) models. However, the vaccine emulsified with FA may induce some side effects, ...
DOI:
10.1016/j.biomaterials.2011.07.009

27. Effect of lateral stiffness coefficient of loader ROPS on human injury in a lateral rollover incident

Author:
Chao Chen; Guoqiang Wang; Yuxin Zhang; Yan Zhang; Junde Si
Source:
Biosystems engineering 2012 v.113 no.2 pp. 207-219
ISSN:
1537-5110
Subject:
agricultural machinery and equipment; animal injuries; dynamic models; humans
Abstract:
... In engineering and agricultural machinery, rollover protective structures (ROPS) are widely used to protect the driver during rollover accidents. In the existing international standards, ROPS performance is verified by a static test and ROPS are often designed according to the finite element method. In this paper, a dynamic analysis of the loader ROPS was conducted to verify the effectiveness of t ...
DOI:
10.1016/j.biosystemseng.2012.08.003

28. Evaluation of nursing adherence to a paper-based graduated continuous intravenous regular human insulin infusion algorithm

Author:
Roland N. Dickerson; Jessica L. Johnson; George O. Maish III; Gayle Minard; Rex O. Brown
Source:
Nutrition 2012 v.28 no.10 pp. 1008-1011
ISSN:
0899-9007
Subject:
glycemic control; animal injuries; nurses; humans; intravenous injection; monitoring; blood glucose; parenteral feeding; hypoglycemia; insulin; patients; hyperglycemia; algorithms
Abstract:
... OBJECTIVE: The use of continuous intravenous regular human insulin (RHI) infusion is often necessary to achieve glycemic control in critically ill patients. Because insulin is a high-risk medication owing to the potential for severe hypoglycemia, it is imperative that insulin infusion algorithms are designed to be safe, effective, and instructionally clear. The safety and efficacy of our intraveno ...
DOI:
10.1016/j.nut.2012.01.010
PubMed:
22658642

29. Hydrogen peroxide enhanced Ca²⁺-activated BK currents and promoted cell injury in human dermal fibroblasts

Author:
Bing Feng; Wen-Lei Ye; Lai-ji Ma; Yun Fang; Yan-Ai Mei; Shao-Min Wei
Source:
Life sciences 2012 v.90 no.11-12 pp. 424-431
ISSN:
0024-3205
Subject:
animal injuries; apoptosis; cell viability; enzyme immunoassays; fibroblasts; humans; hydrogen peroxide; oxidative stress; potassium; potassium channels; protein kinase C; survival rate
Abstract:
... AIMS: Recent studies have shown that dermal fibroblasts possess multiple types of voltage-dependent K⁺ channels, and the activation of these channels induces apoptosis. In the present study, we aimed to investigate whether hydrogen peroxide (H₂O₂), an oxidative stress inducer, could modulate these channels or induce human dermal fibroblasts injury. MAIN METHODS: The effects of H₂O₂ on K⁺ currents ...
DOI:
10.1016/j.lfs.2011.12.020

30. In vitro genotoxicity/antigenotoxicity testing of some conjugated linoleic acid isomers using comet assay

Author:
Francesca Blasi; Luca Dominici; Massimo Moretti; Milena Villarini; Silvia Maurelli; Maria Stella Simonetti; Pietro Damiani; Lina Cossignani
Source:
European journal of lipid science and technology 2012 v.114 no.9 pp. 1016-1024
ISSN:
1438-7697
Subject:
DNA; DNA damage; animal injuries; body composition; conjugated linoleic acid; dietary supplements; genotoxicity; hepatoma; high performance liquid chromatography; humans; isomers; oils
Abstract:
... Recently CLA isomers have received considerable attention as potential anti‐cancer agents. The aim of the study was to assess the genotoxicity/antigenotoxicity in vitro of linoleic acid (LA, c,c‐C18:2, Δ‐9), CLA isomer mixtures and homogeneous CLA TAGs (TriCLA) using the comet assay, to evaluate the effects on the extent of DNA injury in human hepatoma (HepG2) cells. The study was carried out both ...
DOI:
10.1002/ejlt.201200064

31. Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

Author:
Paul Lu; Yaozhi Wang; Lori Graham; Karla McHale; Mingyong Gao; Di Wu; John Brock; Armin Blesch; Ephron S. Rosenzweig; Leif A. Havton; Binhai Zheng; James M. Conner; Martin Marsala; Mark H. Tuszynski
Source:
Cell 2012 v.150 no.6 pp. 1264-1273
ISSN:
0092-8674
Subject:
adults; animal injuries; axons; electrophysiology; fibrin; humans; medicinal properties; phenotype; spinal cord; stem cells
Abstract:
... Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells differentiated into multiple cellular phenotypes, including neurons, which extended large numbers of axons over remarkable distances. Extending axons formed abundant synapses with host cells. Axonal growth was partially depen ...
DOI:
10.1016/j.cell.2012.08.020
PubMed:
22980985
PubMed Central:
PMC3445432

32. Mammalian wound healing, an evolutionary process linked to plant’s response to stress: another proof toward unified healing mechanisms

Author:
Mohaddeseh Behjati
Source:
Acta physiologiae plantarum 2012 v.34 no.4 pp. 1565-1570
ISSN:
0137-5881
Subject:
animal injuries; cell division; cell membranes; cell walls; humans; metabolism; plant damage; plant response; stress response; tissue repair
Abstract:
... Wound healing is a complex reparative process not restricted to humans. This unique process is observed in each wounded living organism which re-sets its own developed healing programs. The gross appearance of the healed wounds vary, but the underlying mechanisms pass through a unified single common path known as “response to stress”. Stressors are internal or external factors with devastative ...
DOI:
10.1007/s11738-011-0922-6

33. Refined sensory measures of neural repair in human spinal cord injury: bridging preclinical findings to clinical value

Author:
Jenny Haefeli; Armin Curt
Source:
Cell and tissue research 2012 v.349 no.1 pp. 397-404
ISSN:
0302-766X
Subject:
animal injuries; animal models; brain; evoked potentials; heat; humans; mechanical damage; spinal cord; tissue repair
Abstract:
... Sensory input from the periphery to the brain can be severely compromised or completely abolished after an injury to the spinal cord. Evidence from animal models suggests that endogenous repair processes in the spinal cord mediate extensive sprouting and that this might be further attenuated by targeted therapeutic interventions. However, the extent to which sprouting can contribute to spontaneous ...
DOI:
10.1007/s00441-012-1373-0
PubMed:
22427116

34. Restoring Voluntary Control of Locomotion after Paralyzing Spinal Cord Injury

Author:
Rubia van den Brand; Janine Heutschi; Quentin Barraud; Jack DiGiovanna; Kay Bartholdi; Michèle Huerlimann; Lucia Friedli; Isabel Vollenweider; Eduardo Martin Moraud; Simone Duis; Nadia Dominici; Silvestro Micera; Pavel Musienko; Grégoire Courtine
Source:
Science 2012 v.336 no.6085 pp. 1182-1185
ISSN:
0036-8075
Subject:
animal injuries; brain stem; cortex; electrochemistry; humans; locomotion; neurons; paralysis; rats; robots; spinal cord
Abstract:
... Half of human spinal cord injuries lead to chronic paralysis. Here, we introduce an electrochemical neuroprosthesis and a robotic postural interface designed to encourage supraspinally mediated movements in rats with paralyzing lesions. Despite the interruption of direct supraspinal pathways, the cortex regained the capacity to transform contextual information into task-specific commands to execut ...
DOI:
10.1126/science.1217416

35. Staphylococcal skin disease in livestock

Author:
Aiden P. Foster
Source:
Veterinary dermatology 2012 v.23 no.4 pp. 342
ISSN:
0959-4493
Subject:
Staphylococcus aureus; Staphylococcus chromogenes; Staphylococcus hyicus; Staphylococcus sciuri; animal injuries; bacteria; cattle; contagious ecthyma; exudative epidermitis; feed troughs; goats; head; humans; mange; pasture plants; public health; sheep; swine; therapeutics; udders
Abstract:
... This review covers cutaneous manifestations of staphylococcal infection in livestock species. Cattle – In cattle, staphylococcal infections may present as folliculitis or as impetigo. Both may present as mild forms of a group of conditions loosely termed udder dermatitis, which has various clinical presentations and does not always involve staphylococci. Goats – In goats, staphylococcal infection ...
DOI:
10.1111/j.1365-3164.2012.01093.x
PubMed:
22823580

36. The neurobiology of people-plant relationships: an evolutionary brain inquiry

Author:
Rice, J.S.
Source:
Acta horticulturae 2012 v. no.954 pp. 21-28
ISSN:
0567-7572
Subject:
animal injuries; antidotes; cortisol; evolution; gardening; humans; models; neocortex; neurodevelopment; neurophysiology; oxytocin; planning; reptiles
Abstract:
... People-Plant research studies the effects of our relationship with plants. Understanding how relationship has contributed to our brain’s evolution may further illuminate our therapeutic interventions and research findings. The triune brain theory posits a model of brain functioning from three separate evolutionary centres (MacLean, 1973). The reptilian brain is the oldest and operates on a fight o ...
DOI:
10.17660/ActaHortic.2012.954.2

37. Tissue engineered regeneration of completely transected spinal cord using human mesenchymal stem cells

Author:
Kkot Nim Kang; Da Yeon Kim; So Mi Yoon; Ju Young Lee; Bit Na Lee; Jin Seon Kwon; Hyo Won Seo; Il Woo Lee; Ha Cheol Shin; Young Man Kim; Hyun Soo Kim; Jae Ho Kim; Byoung Hyun Min; Hai Bang Lee; Moon Suk Kim
Source:
Biomaterials 2012 v.33 no.19 pp. 4828-4835
ISSN:
0142-9612
Subject:
animal injuries; cell viability; humans; immunohistochemistry; locomotion; models; nerve tissue; neurons; paralysis; rats; spinal cord; stem cells; vertebrae
Abstract:
... The present study employed a combinatorial strategy using poly(d,l-lactide-co-glycolide) (PLGA) scaffolds seeded with human mesenchymal stem cells (hMSCs) to promote cell survival, differentiation, and neurological function in a completely transected spinal cord injury (SCI) model. The SCI model was prepared by complete removal of a 2-mm length of spinal cord in the eighth-to-ninth spinal vertebra ...
DOI:
10.1016/j.biomaterials.2012.03.043

38. Application of human mesenchymal and pluripotent stem cell microcarrier cultures in cellular therapy: Achievements and future direction

Author:
Allen Kuan-Liang Chen; Shaul Reuveny; Steve Kah Weng Oh
Source:
Biotechnology Advances 2013 v.31 pp. 1032-1046
ISSN:
0734-9750
Subject:
animal injuries; bioprocessing; cartilage; cell culture; clinical trials; coatings; humans; immune response; induced pluripotent stem cells; shear stress; sowing; spinal cord; therapeutics; tissue culture; vaccines
Abstract:
... Mesenchymal stem cells (MSCs) have recently made significant progress with multiple clinical trials targeting modulation of immune responses, regeneration of bone, cartilage, myocardia, and diseases like Metachromatic leukodystrophy and Hurler syndrome. On the other hand, the use of human embryonic and induced pluripotent stem cells (hPSCs) in clinical trials is rather limited mainly due to safety ...
DOI:
10.1016/j.biotechadv.2013.03.006

39. Causes of mortality and pathological lesions observed post-mortem in red squirrels (Sciurus vulgaris) in Great Britain

Author:
Victor R Simpson; Judith Hargreaves; Helen M Butler; Nicholas J Davison; David J Everest
Source:
BMC veterinary research 2013 v.9 no.1 pp. 229
ISSN:
1746-6148
Subject:
Anoplura; Bordetella bronchiseptica; Sciurus; Siphonaptera; Staphylococcus aureus; adenoma; animal injuries; bacterial infections; bronchopneumonia; candidiasis; capillariasis; carcinoma; cats; cholecalciferol; chylothorax; death; dermatitis; dogs; ears; etiology; humans; hyperplasia; mortality; poisoning; predation; predators; rodenticides; squirrels; ticks; toxoplasmosis; traffic; England; Scotland
Abstract:
... BACKGROUND: The red squirrel population in Great Britain has declined dramatically in recent decades, principally due to squirrelpox. Concern exists that red squirrels may become extinct nationally and, as there has been limited research in to diseases other than squirrelpox, this study aimed to identify additional causes of mortality. RESULTS: Post-mortem examinations on 163 red squirrels found d ...
DOI:
10.1186/1746-6148-9-229
PubMed:
24238087
PubMed Central:
PMC4225685

40. Core-shell nanoparticle controlled hATSCs neurogenesis for neuropathic pain therapy

Author:
Jee In Choi; Hyun Tae Cho; Min Ki Jee; Soo Kyung Kang
Source:
Biomaterials 2013 v.34 no.21 pp. 4956-4970
ISSN:
0142-9612
Subject:
animal injuries; cell culture; cell proliferation; cellular microenvironment; glutathione peroxidase; humans; iron oxides; islets of Langerhans; lesions (animal); medicine; models; nanoparticles; neurogenesis; pain; proteins; stem cells; therapeutics; tissue engineering; tissues; zinc oxide
Abstract:
... A stem cell-based strategy for tissue engineering in regenerative medicine is crucial to produce and effective therapeutic replacement of injured or damaged tissues. This type of therapeutic replacement requires interaction with the cells and tissues via the incorporation of a beneficial physical microenvironment and cellular biochemical signals. Recently, we studied a cell-function modifying fact ...
DOI:
10.1016/j.biomaterials.2013.02.037

41. Disuse-induced muscle wasting

Author:
Sue C. Bodine
Source:
international journal of biochemistry & cell biology 2013 v.45 no.10 pp. 2200-2208
ISSN:
1357-2725
Subject:
animal injuries; cell biology; elderly; humans; models; muscles; muscular atrophy; protein degradation; protein synthesis; skeletal muscle; spinal cord
Abstract:
... Loss of skeletal muscle mass occurs frequently in clinical settings in response to joint immobilization and bed rest, and is induced by a combination of unloading and inactivity. Disuse-induced atrophy will likely affect every person in his or her lifetime, and can be debilitating especially in the elderly. Currently there are no good therapies to treat disuse-induced muscle atrophy, in part, due ...
DOI:
10.1016/j.biocel.2013.06.011
PubMed:
23800384
PubMed Central:
PMC3856924

42. Ghrelin protects human pulmonary artery endothelial cells against hypoxia-induced injury via PI3-kinase/Akt

Author:
Dan Yang; Zhihong Liu; Hongliang Zhang; Qin Luo
Source:
Peptides 2013 v.42 no. pp. 112-117
ISSN:
0196-9781
Subject:
anaerobic conditions; animal injuries; cell viability; endothelial cells; endothelial nitric oxide synthase; ghrelin; humans; hypertension; hypoxia; nitric oxide; normoxia; phosphatidylinositol 3-kinase; phosphorylation; polycyclic aromatic hydrocarbons; protective effect; pulmonary artery; secretion
Abstract:
... Endothelial injury and diminished NO release induced by hypoxia is thought to be a critical factor in the development of pulmonary artery hypertension (PAH). Ghrelin (Ghr) is a well-characterized hormone and has protective effects on the cardiovascular system, specifically by promoting the vascular endothelial cell function. The aim of this study was to investigate the effect of the Ghr on the hyp ...
DOI:
10.1016/j.peptides.2013.01.012

43. Organic bioelectrodes in clinical neurosurgery

Author:
Hans von Holst
Source:
BBA - General Subjects 2013 v.1830 pp. 4345-4352
ISSN:
0304-4165
Subject:
animal injuries; brain; computed tomography; electrodes; humans; image analysis; neoplasms; nerve tissue; patients; peripheral nervous system; polymers; spinal cord; surgery
Abstract:
... Clinical neurosurgery deals with surgical procedures and intensive care of illnesses in the human central and peripheral nervous system. Neurosurgery should be looked upon as a high-tech specialty and very much dependent on new technological innovations aiming at improvements of patient's treatment and outcome. During the last decades neurosurgery has improved substantially thanks to the introduct ...
DOI:
10.1016/j.bbagen.2012.10.013

44. Protective effect of Echinops galalensis against CCl4-induced injury on the human hepatoma cell line (Huh7)

Author:
Hossam M. Abdallah; Shahira M. Ezzat; Riham Salah El Dine; Essam Abdel-Sattar; Ashraf B. Abdel-Naim
Source:
Phytochemistry letters 2013 v.6 no.1 pp. 73-78
ISSN:
1874-3900
Subject:
Echinops; aerial parts; alanine transaminase; animal injuries; antioxidant activity; aspartate transaminase; beta-sitosterol; carbon tetrachloride; erythrodiol; flowering; hepatoma; hepatoprotective effect; humans; malondialdehyde; metabolites; methanol; nuclear magnetic resonance spectroscopy; pretreatment; superoxide dismutase
Abstract:
... Phytochemical investigation of the flowering aerial parts of Echinops galalensis (Asteraceae) led to the isolation of a new taraxasteryl triterpene, 3β-acetoxy-taraxast-12, 20(30)-diene-11α-21α-diol (1), together with nine known metabolites, α-amyrin (2), β-sitosterol (3), erythrodiol (4), lup-20(29)-ene-1,3-diol (5), 1,5-dicaffeoylquinic acid (6), 3,5-dicaffeoylquinic acid (7), 3,4-dicaffeoylquin ...
DOI:
10.1016/j.phytol.2012.10.012

45. A05 Session 1: Translational Hibernation

Author:
Shannon N. Tessier; Kenneth B. Storey
Source:
Cryobiology 2014 v.69 no.1 pp. 185
ISSN:
0011-2240
Subject:
Sciuridae; adverse effects; age; animal injuries; brain; cold treatment; drugs; energy; epigenetics; fuels; gene expression regulation; genes; genotype; hibernation; histones; human health; humans; hypothermia; medical facilities; metabolism; methylation; mitogen-activated protein kinase; myocardial infarction; patients; phenotype; signal transduction; spinal cord; stress tolerance; stroke; transcription factors; viability
Abstract:
... The ability to induce a hypometabolic state holds immense clinical promise since it serves as a means of lowering tissue energy needs and reducing ischemia damage; however, is also associated with many adverse effects in humans and most mammals. Nonetheless, hypometabolic states produced by drug administration or chilling have been applied for treatment of stroke, heart attack, multiple organ fail ...
DOI:
10.1016/j.cryobiol.2014.06.014

46. Dose–injury relationships for cryoprotective agent injury to human chondrocytes

Author:
M.D. Fahmy; K.A. Almansoori; L. Laouar; V. Prasad; L.E. McGann; J.A.W. Elliott; N.M. Jomha
Source:
Cryobiology 2014 v.68 no.1 pp. 50-56
ISSN:
0011-2240
Subject:
animal injuries; cartilage; cell death; chondrocytes; dimethyl sulfoxide; ethylene glycol; glycerol; humans; least squares; patients; propylene glycol; surgery; t-test; viability; vitrification
Abstract:
... Vitrification of articular cartilage (AC) could enhance tissue availability but requires high concentrations of cyroprotective agents (CPAs). This study investigated relative injuries caused by commonly used CPAs. We hypothesized that the in situ chondrocyte dose–injury relationships of five commonly used CPAs are nonlinear and that relative injuries could be determined by comparing cell death aft ...
DOI:
10.1016/j.cryobiol.2013.11.006

47. Hypoxia-conditioned media allows species-specific attraction of bone marrow stromal cells without need for recombinant proteins

Author:
Anastasia Gabrielyan; Sven Knaak; Michael Gelinsky; Stefan Arnhold; Angela Rösen-Wolff
Source:
BMC veterinary research 2014 v.10 no.1 pp. 56
ISSN:
1746-6148
Subject:
animal injuries; antibodies; bone marrow; cytokines; dogs; growth factors; horses; humans; osteoblasts; recombinant proteins; resection; sheep; stem cells; stromal cells; tissue repair
Abstract:
... BACKGROUND: In vivo tissue regeneration depends on migration of stem cells into injured areas, their differentiation into specific cell types, and their interaction with other cells that are necessary to generate new tissue. Human mesenchymal stem cells, a subset of bone marrow stromal cells (BMSCs), can migrate and differentiate into osteoblasts in bone tissue. This can be facilitated by recombin ...
DOI:
10.1186/1746-6148-10-56
PubMed:
24593914
PubMed Central:
PMC3974005

48. Magnetic manipulation of bacterial magnetic nanoparticle-loaded neurospheres

Author:
Jaeha Shin; Kyung-Mee Lee; Jae Hyup Lee; Junghoon Lee; Misun Cha
Source:
Integrative biology 2014 v.6 no.5 pp. 532-539
ISSN:
1757-9708
Subject:
animal injuries; humans; magnetic fields; models; nanoparticles; neurons; spinal cord; stem cells; tissue repair
Abstract:
... Specific targeting of cells to sites of tissue damage and delivery of high numbers of transplanted cells to lesion tissue in vivo are critical parameters for the success of cell-based therapies. Here, we report a promising in vitro model system for studying the homing of transplanted cells, which may eventually be applicable for targeted regeneration of damaged neurons in spinal cord injury. In th ...
DOI:
10.1039/c3ib40195b

49. Neuroprotective ferulic acid (FA)–glycol chitosan (GC) nanoparticles for functional restoration of traumatically injured spinal cord

Author:
Wei Wu; Seung-Young Lee; Xiangbing Wu; Jacqueline Y. Tyler; He Wang; Zheng Ouyang; Kinam Park; Xiao-Ming Xu; Ji-Xin Cheng
Source:
Biomaterials 2014 v.35 no.7 pp. 2355-2364
ISSN:
0142-9612
Subject:
animal injuries; spinal cord; humans; intravenous injection; chitosan; histology; inflammation; models; axons; methylprednisolone; myelin sheath; in vitro studies; rats; nanoparticles; ferulic acid; adverse effects
Abstract:
... An urgent unmet need exists for early-stage treatment of spinal cord injury (SCI). Currently methylprednisolone is the only therapeutic agent used in clinics, for which the efficacy is controversial and the side effect is well-known. We demonstrated functional restoration of injured spinal cord by self-assembled nanoparticles composed of ferulic acid modified glycol chitosan (FA–GC). Chitosan and ...
DOI:
10.1016/j.biomaterials.2013.11.074
PubMed:
24332460
PubMed Central:
PMC4370233

50. Surgical decompression in acute spinal cord injury: A review of clinical evidence, animal model studies, and potential future directions of investigation

Author:
Yiping Li; Chandler L. Walker; Yi Ping Zhang; Christopher B. Shields; Xiao-Ming Xu
Source:
Frontiers in biology 2014 v.9 no.2 pp. 127-136
ISSN:
1674-7984
Subject:
animal injuries; animal models; humans; patients; spinal cord; surgery
Abstract:
... The goal for treatment in acute spinal cord injury (SCI) is to reduce the extent of secondary damage and facilitate neurologic regeneration and functional recovery. Although multiple studies have investigated potential new therapies for the treatment of acute SCI, outcomes and management protocols aimed at ameliorating neurologic injury in patients remain ineffective. More recent clinical and basi ...
DOI:
10.1007/s11515-014-1297-z
PubMed:
24899887
PubMed Central:
PMC4041293

51. Traumatic coagulopathy‐Part 1: Pathophysiology and diagnosis

Author:
Lee Palmer; Linda Martin
Source:
Journal of veterinary emergency and critical care 2014 v.24 no.1 pp. 63-74
ISSN:
1479-3261
Subject:
animal injuries; blood platelet count; coagulation; disseminated intravascular coagulation; fibrinogen; hemorrhage; humans; inflammation; mortality; pathophysiology; patients; people; phenotype; prognosis; prothrombin; therapeutics; thromboplastin; viscoelasticity
Abstract:
... OBJECTIVE: To review the current literature in reference to the pathophysiology and diagnostic modalities available for acute traumatic coagulopathy (ATC) in relationship to traumatic hemorrhagic shock. ETIOLOGY: Posttraumatic hemorrhage is responsible for one of the leading causes of preventable human deaths worldwide. Acute traumatic coagulopathy is an endogenous hypocoagulable condition that ha ...
DOI:
10.1111/vec.12130
PubMed:
24382014

52. Traumatic coagulopathy‐Part 2: Resuscitative strategies

Author:
Lee Palmer; Linda Martin
Source:
Journal of veterinary emergency and critical care 2014 v.24 no.1 pp. 75-92
ISSN:
1479-3261
Subject:
acidosis; animal experimentation; animal injuries; animal models; death; etiology; hemorrhage; hemostasis; humans; hypothermia; patients; veterinarians; veterinary medicine; viscoelasticity
Abstract:
... OBJECTIVE: To discuss the current resuscitative strategies for trauma‐induced hemorrhagic shock and acute traumatic coagulopathy (ATC). ETIOLOGY: Hemorrhagic shock can be acutely fatal if not immediately and appropriately treated. The primary tenets of hemorrhagic shock resuscitation are to arrest hemorrhage and restore the effective circulating volume. Large volumes of isotonic crystalloids have ...
DOI:
10.1111/vec.12138
PubMed:
24393363

53. Using caffeine and other adenosine receptor antagonists and agonists as therapeutic tools against neurodegenerative diseases: A review

Author:
Marla Rivera-Oliver; Manuel Díaz-Ríos
Source:
Life sciences 2014 v.101 no.1-2 pp. 1-9
ISSN:
0024-3205
Subject:
Alzheimer disease; agonists; animal injuries; animal models; antagonists; apoptosis; brain; caffeine; cognition; disease course; drug delivery systems; drugs; heart rate; humans; infarction; inflammation; memory; neurodegenerative diseases; neuroprotective effect; neurotransmitters; patients; purinergic receptors; sleep; spinal cord; stroke; synaptic transmission
Abstract:
... Caffeine is the most consumed pychostimulant in the world, and it is known to affect basic and fundamental human processes such as sleep, arousal, cognition and learning and memory. It works as a nonselective blocker of adenosine receptors (A1, A2a, A2b and A3) and has been related to the regulation of heart rate, the contraction/relaxation of cardiac and smooth muscles, and the neural signaling i ...
DOI:
10.1016/j.lfs.2014.01.083
PubMed:
24530739
PubMed Central:
PMC4115368

54. Botryococcus braunii and Nannochloropsis oculata extracts inhibit cholinesterases and protect human dopaminergic SH-SY5Y cells from H2O 2-induced cytotoxicity

Author:
Luísa Custódio; Fernando Soares; Hugo Pereira; Maria João Rodrigues; Luísa Barreira; Amélia Pilar Rauter; Fernando Alberício; João Varela
Source:
Journal of applied phycology 2015 v.27 no.2 pp. 839-848
ISSN:
0921-8971
Subject:
Botryococcus; Nannochloropsis; acetone; acetylcholinesterase; animal injuries; antioxidant activity; biomass; chelation; copper; cytotoxicity; ethyl ether; free radical scavengers; functional foods; hexane; humans; hydrogen peroxide; iron; microalgae; neurons; oxidative stress; pharmaceutical industry; polyunsaturated fatty acids
Abstract:
... Extracts of Botryococcus braunii and Nannochloropsis oculata were evaluated for inhibitory activity against acetylcholinesterase (AChE), butyrylcholinesterase (BChE) and tyrosinase (TYRO) and capacity to attenuate hydrogen peroxide (H₂O₂)-induced injury in the human dopaminergic cell line SH-SY5Y. We also report the antioxidant activity, the total phenolic content (TPC) and the fatty acid (FA) pro ...
DOI:
10.1007/s10811-014-0369-4

55. Drug delivery, cell-based therapies, and tissue engineering approaches for spinal cord injury

Author:
Shushi Kabu; Yue Gao; Brian K. Kwon; Vinod Labhasetwar
Source:
Journal of Controlled Release 2015 v.219 pp. 141-154
ISSN:
0168-3659
Subject:
animal injuries; animal models; drugs; humans; neurons; spinal cord; tissue engineering; toxicity
Abstract:
... Spinal cord injury (SCI) results in devastating neurological and pathological consequences, causing major dysfunction to the motor, sensory, and autonomic systems. The primary traumatic injury to the spinal cord triggers a cascade of acute and chronic degenerative events, leading to further secondary injury. Many therapeutic strategies have been developed to potentially intervene in these progress ...
DOI:
10.1016/j.jconrel.2015.08.060
PubMed:
26343846
PubMed Central:
PMC4656085

56. Identification and functional characterization of intracellular sialidase NeuA3 from Streptomyces avermitilis

Author:
Jia Guo; Yicheng Wang; Bo Song; Xin Wang; Ganglong Yang; Feng Guan
Source:
Process Biochemistry 2015 v.50 pp. 752-758
ISSN:
1359-5113
Subject:
Alzheimer disease; Escherichia coli; Parkinson disease; Streptomyces avermitilis; animal injuries; bacteria; brain; divalent metals; gangliosides; genes; glycoconjugates; humans; industrial applications; metal ions; molecular weight; neoplasm cells; oligosaccharides; pH; sialic acids; sialidase; spinal cord; substrate specificity; swine; temperature; urinary bladder neoplasms
Abstract:
... Sialidases (EC 3.2.1.18), glycosidases that cleave the linkages whereby sialic acids are attached to glycoconjugates, are found in most bacterial species. Because sialidases can convert polysialogangliosides to monosialoganglioside GM1, they have potential clinical application for treatment of human neurological and other disorders including Alzheimer's disease, Parkinson's disease, and spinal cor ...
DOI:
10.1016/j.procbio.2015.02.005

57. Regeneration of Xenopus laevis spinal cord requires Sox2/3 expressing cells

Author:
Rosana Muñoz; Gabriela Edwards-Faret; Mauricio Moreno; Nikole Zuñiga; Hollis Cline; Juan Larraín
Source:
Developmental biology 2015 v.408 pp. 229-243
ISSN:
0012-1606
Subject:
Xenopus laevis; animal injuries; green fluorescent protein; humans; image analysis; in vivo studies; larvae; metamorphosis; models; neurogenesis; neurons; spinal cord; stem cells; swimming
Abstract:
... Spinal cord regeneration is very inefficient in humans, causing paraplegia and quadriplegia. Studying model organisms that can regenerate the spinal cord in response to injury could be useful for understanding the cellular and molecular mechanisms that explain why this process fails in humans. Here, we use Xenopus laevis as a model organism to study spinal cord repair. Histological and functional ...
DOI:
10.1016/j.ydbio.2015.03.009
PubMed:
25797152
PubMed Central:
PMC4826040

58. Surgical procedure of extracting teeth for obtaining dental pulp for regenerative medicine in swine

Author:
R Sasaki; H Matsumine; Y Watanabe; M Yamato; T Ando
Source:
Laboratory animals 2015 v.49 no.2 pp. 172-176
ISSN:
1758-1117
Subject:
animal injuries; animal models; harvesting; humans; laboratory animals; males; medicine; miniature swine; nerve tissue; osteotomy; spinal cord; stroke; swine; tooth pulp
Abstract:
... Dental pulp is a potential source of cells that can be used in cell replacement therapy for various nerve disorders, including stroke, spinal cord injury, and peripheral nerve defect. However, the validation of an animal model closely related to humans is needed in translational research. The miniature pig is a suitable experimental model in maxillofacial surgery, because its anatomical structure ...
DOI:
10.1177/0023677214560002

59. A new three dimensional biomimetic hydrogel to deliver factors secreted by human mesenchymal stem cells in spinal cord injury

Author:
Ilaria Caron; Filippo Rossi; Simonetta Papa; Rossella Aloe; Marika Sculco; Emanuele Mauri; Alessandro Sacchetti; Eugenio Erba; Nicolò Panini; Valentina Parazzi; Mario Barilani; Gianluigi Forloni; Giuseppe Perale; Lorenza Lazzari; Pietro Veglianese
Source:
Biomaterials 2016 v.75 pp. 135-147
ISSN:
0142-9612
Subject:
agarose; animal injuries; animal models; biocompatible materials; biomimetics; encapsulation; extracellular matrix; freeze drying; humans; hydrocolloids; mechanical stress; spinal cord; stem cells; therapeutics; viability
Abstract:
... Stem cell therapy with human mesenchymal stem cells (hMSCs) represents a promising strategy in spinal cord injury (SCI). However, both systemic and parenchymal hMSCs administrations show significant drawbacks as a limited number and viability of stem cells in situ. Biomaterials able to encapsulate and sustain hMSCs represent a viable approach to overcome these limitations potentially improving the ...
DOI:
10.1016/j.biomaterials.2015.10.024

60. Chitosan scaffolds induce human dental pulp stem cells to neural differentiation: potential roles for spinal cord injury therapy

Author:
Jinlong Zhang; Xiaohui Lu; Guijuan Feng; Zhifeng Gu; Yuyu Sun; Guofeng Bao; Guanhua Xu; Yuanzhou Lu; Jiajia Chen; Lingfeng Xu; Xingmei Feng; Zhiming Cui
Source:
Cell and tissue research 2016 v.366 no.1 pp. 129-142
ISSN:
0302-766X
Subject:
Western blotting; animal injuries; animal models; cell viability; chitosan; genes; humans; neurons; neurotrophins; polymerase chain reaction; reverse transcription; secretion; signal transduction; spinal cord; stem cells; therapeutics; tooth pulp
Abstract:
... Cell-based transplantation strategies hold great potential for spinal cord injury (SCI) repair. Chitosan scaffolds have therapeutic benefits for spinal cord regeneration. Human dental pulp stem cells (DPSCs) are abundant available stem cells with low immunological incompatibility and can be considered for cell replacement therapy. The purpose of this study is to investigate the role of chitosan sc ...
DOI:
10.1007/s00441-016-2402-1

61. Confocal raman microspectral imaging of ex vivo human spinal cord tissue

Author:
Shuang Wang; Zhuowen Liang; Yuzhe Gong; Yaning Yin; Kaige Wang; Qingli He; Zhe Wang; Jintao Bai
Source:
Journal of photochemistry and photobiology 2016 v.163 pp. 177-184
ISSN:
1011-1344
Subject:
animal injuries; chemical composition; cluster analysis; glycosaminoglycans; heme; humans; image analysis; spinal cord
Abstract:
... Confocal Raman microspectral imaging (CRMI) provides a versatile tool to illustrate the biochemical nature and structure of biological tissue without introducing any external labels. In this work, a precise correlation was established between the biochemical profile and histological architecture of ex vivo human spinal cord tissue by using CRMI with 633nm excitation. After precisely linking the sp ...
DOI:
10.1016/j.jphotobiol.2016.08.032

62. Glucagon-like peptide 2 and its beneficial effects on gut function and health in production animals

Author:
E.E. Connor; C.M. Evock-Clover; E.H. Wall; R.L. Baldwin; M. Santin-Duran; T.H. Elsasser; D.M. Bravo
Source:
Domestic animal endocrinology 2016 v.56 pp. S56
ISSN:
0739-7240
Subject:
absorption; animal injuries; animal models; appetite; dairy calves; energy metabolism; food animals; glucagon-like peptides; health foods; humans; inflammation; inflammatory bowel disease; intestinal mucosa; mechanism of action; pathogenesis; peptides; protozoal infections; rodents; swine
Abstract:
... Numerous endocrine cell subtypes exist within the intestinal mucosa and produce peptides contributing to the regulation of critical physiological processes including appetite, energy metabolism, gut function, and gut health. The mechanisms of action and the extent of the physiological effects of these enteric peptides are only beginning to be uncovered. One peptide in particular, glucagon-like pep ...
Handle:
10113/62722
DOI:
10.1016/j.domaniend.2015.11.008

63. Inhalation dosimetry modeling provides insights into regional respiratory tract toxicity of inhaled diacetyl

Author:
Joseph A. Cichocki; John B. Morris
Source:
Toxicology 2016 pp. -
ISSN:
0300-483X
Subject:
animal injuries; breathing; diacetyl; fluid mechanics; humans; inhalation exposure; models; mouth; pharmacokinetics; prediction; rats; respiratory system; risk; toxicity; toxicity testing; vapors
Abstract:
... Vapor dosimetry models provide a means of assessing the role of delivered dose in determining the regional airway response to inspired vapors. A validated hybrid computational fluid dynamics physiologically based pharmacokinetic model for inhaled diacetyl has been developed to describe inhaled diacetyl dosimetry in both the rat and human respiratory tracts. Comparison of the distribution of respir ...
DOI:
10.1016/j.tox.2016.11.007

64. Inhibition of hydrogen peroxide induced injuring on human skin fibroblast by Ulva prolifera polysaccharide

Author:
Chuner Cai; Ziye Guo; Yayun Yang; Zhonglei Geng; Langlang Tang; Minglin Zhao; Yuyan Qiu; Yifan Chen; Peimin He
Source:
International journal of biological macromolecules 2016 v.91 pp. 241-247
ISSN:
0141-8130
Subject:
Ulva prolifera; animal injuries; cell proliferation; cosmetics; fibroblasts; glutathione peroxidase; humans; hydrogen peroxide; molecular weight; polysaccharides; sulfates
Abstract:
... Ulva prolifera can protect human skin fibroblast from being injured by hydrogen peroxide. This work studied the composition of Ulva prolifera polysaccharide and identified its physicochemical properties. The results showed that the cell proliferation of 0.5mg/mL crude polysaccharide was 154.4% of that in negative control group. Moreover, ROS detection indices, including DCFH-DA, GSH-PX, MDA and CA ...
DOI:
10.1016/j.ijbiomac.2016.05.071

65. Injectable hydrogel promotes early survival of induced pluripotent stem cell-derived oligodendrocytes and attenuates longterm teratoma formation in a spinal cord injury model

Author:
T. Führmann; R.Y. Tam; B. Ballarin; B. Coles; I. Elliott Donaghue; D. van der Kooy; A. Nagy; C.H. Tator; C.M. Morshead; M.S. Shoichet
Source:
Biomaterials 2016 v.83 pp. 23-36
ISSN:
0142-9612
Subject:
animal injuries; biocompatible materials; cell adhesion; cell differentiation; cell viability; humans; hyaluronic acid; hydrocolloids; methylcellulose; models; neoplasms; oligodendroglia; phenotype; platelet-derived growth factor; progeny; rats; spinal cord; stem cells
Abstract:
... Transplantation of pluripotent stem cells and their differentiated progeny has the potential to preserve or regenerate functional pathways and improve function after central nervous system injury. However, their utility has been hampered by poor survival and the potential to form tumors. Peptide-modified biomaterials influence cell adhesion, survival and differentiation in vitro, but their effecti ...
DOI:
10.1016/j.biomaterials.2015.12.032

66. Is wounding aggression in zoo‐housed chimpanzees and ring‐tailed lemurs related to zoo visitor numbers?

Author:
Geoff Hosey; Vicky Melfi; Isabel Formella; Samantha J. Ward; Marina Tokarski; Dave Brunger; Sara Brice; Sonya P. Hill
Source:
Zoo biology 2016 v.35 no.3 pp. 205-209
ISSN:
0733-3188
Subject:
Lemur catta; Pan troglodytes; aggression; animal injuries; anthropogenic activities; captive animals; humans; people; zoos
Abstract:
... Chimpanzees in laboratory colonies experience more wounds on weekdays than on weekends, which has been attributed to the increased number of people present during the week; thus, the presence of more people was interpreted as stressful. If this were also true for primates in zoos, where high human presence is a regular feature, this would clearly be of concern. Here we examine wounding rates in tw ...
DOI:
10.1002/zoo.21277

67. Lentivirus-mediated transfection of chondroitinase ABC gene without the bacterial leader sequence enables long-term secretion of functional chondroitinase ABC in human bone marrow stromal cells

Author:
Yang Guo; Michael Klüppel; Hao Tang; Sheng Tan; Peidong Zhang; Zhenzhou Chen
Source:
Biotechnology letters 2016 v.38 no.5 pp. 893-900
ISSN:
0141-5492
Subject:
Lentivirus; Western blotting; animal injuries; bone marrow; enzyme-linked immunosorbent assay; genes; humans; in vitro culture; proteins; secretion; spinal cord; stromal cells; transfection
Abstract:
... OBJECTIVE: To test the feasibility of secretion of functional chondroitinase ABC (ChABC), a bacterial enzyme that promotes axonal regeneration after spinal cord injury, from human bone marrow stromal cells (hBMSCs). RESULTS: A lentiviral-expression vector, Lenti6.3-ChABC-3F, carrying the ChABC-3F gene without the bacterial leader sequence (aa 1-24) was constructed. Transfection of these Lenti6.3-C ...
DOI:
10.1007/s10529-016-2046-y

68. Protective effects of polyvinylpyrrolidone-wrapped fullerene against intermittent ultraviolet-A irradiation-induced cell injury in HaCaT cells

Author:
Yasukazu Saitoh; Hiroaki Ohta; Sayuri Hyodo
Source:
Journal of photochemistry and photobiology 2016 v.163 pp. 22-29
ISSN:
1011-1344
Subject:
fullerene; animal injuries; dose response; humans; oxidative stress; models; alpha-tocopherol; chromatin; keratinocytes; superoxide anion; antioxidant activity; ultraviolet radiation; apoptosis; protective effect
Abstract:
... To identify compounds that suppress UV irradiation-induced oxidative stress in the skin, various types of antioxidants have been studied. Polyvinylpyrrolidone-entrapped fullerene (C60/PVP) is known as a powerful antioxidant that exerts a cytoprotective effect against UV irradiation-induced cell injury in human skin cells and skin models. However, the effects of the alternate attractive C60/PVP fea ...
DOI:
10.1016/j.jphotobiol.2016.08.001

69. Reduced heart rate variability in pet dogs affected by anxiety-related behaviour problems

Author:
Dennis Wormald; Andrew J Lawrence; Gabrielle Carter; Andrew D Fisher
Source:
Physiology & behavior 2016 pp. -
ISSN:
0031-9384
Subject:
animal injuries; behavior disorders; behavior problems; cortisol; dogs; heart rate; humans; pathophysiology; questionnaires; statistical analysis
Abstract:
... We present here the first evidence of correlation between canine anxiety-related behavioural problems and heart rate variability (HRV). HRV is known to be related to a range of mental disorders in humans; however this has not been explored in dogs. Behavioural problems in dogs can result in suffering, property destruction and human injury. Dog behaviour problems were assessed by owner questionnair ...
DOI:
10.1016/j.physbeh.2016.11.003

70. A review of associated controversies surrounding glucocorticoid use in veterinary emergency and critical care

Author:
Maya A. Aharon; Jennifer E. Prittie; Kate Buriko
Source:
Journal of veterinary emergency and critical care 2017 v.27 no.3 pp. 267-277
ISSN:
1479-3261
Subject:
acute respiratory distress syndrome; adverse effects; anaphylaxis; animal injuries; brain; cortisol; dexamethasone; gastrointestinal system; humans; hyperglycemia; lungs; methylprednisolone; morbidity; mortality; pneumonia; prednisone; septic shock; spinal cord; urinary tract diseases; veterinary medicine
Abstract:
... OBJECTIVE: To review the literature in human and veterinary medicine regarding the indications for, efficacy of, and controversies surrounding glucocorticoid (GC) administration in the emergency and critical care (ECC) setting, and to provide an overview of the most commonly used synthetic GC formulations. MEDICATIONS: Synthetic GCs vary in GC and mineralocorticoid potency, hypothalamic pituitary ...
DOI:
10.1111/vec.12603

71. Antioxidant properties, protein binding capacity and mineral contents of some plants traditionally used in the management of animal wounds

Author:
A. Marume; S. Khoza; G. Matope; T.T. Nyakudya; T. Mduluza; A.R. Ndhlala
Source:
South African journal of botany 2017 v.111 pp. 23-28
ISSN:
0254-6299
Subject:
2,2-diphenyl-1-picrylhydrazyl; Adenium; Cissus quadrangularis; Erythrina abyssinica; aluminum; animal injuries; antioxidant activity; bark; binding capacity; flavonoids; herbal medicines; humans; indigenous knowledge; leaf extracts; median effective concentration; medicinal plants; mineral content; models; phytopharmaceuticals; protein binding; Zimbabwe
Abstract:
... Herbal medicines are considered an intricate and integral part of humankind's knowledge systems. Time has proven their efficacy and safety for both human and animal applications. Modern science, guided by indigenous knowledge systems can further optimize the use of various herbal products. To widen the current focus on herbal medicines, a study was carried-out to determine antioxidant properties, ...
DOI:
10.1016/j.sajb.2017.03.003

72. Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury

Author:
Jonathan R. Slotkin; Christopher D. Pritchard; Brian Luque; Janice Ye; Richard T. Layer; Mathew S. Lawrence; Timothy M. O'Shea; Roland R. Roy; Hui Zhong; Isabel Vollenweider; V. Reggie Edgerton; Grégoire Courtine; Eric J. Woodard; Robert Langer
Source:
Biomaterials 2017 v.123 pp. 63-76
ISSN:
0142-9612
Subject:
Chlorocebus sabaeus; animal injuries; animal models; astrocytes; biodegradability; clinical trials; composite polymers; humans; kinematics; locomotion; macrophages; monkeys; muscles; myelin basic protein; neurons; rats; spinal cord; sprouting
Abstract:
... Tissue loss significantly reduces the potential for functional recovery after spinal cord injury. We previously showed that implantation of porous scaffolds composed of a biodegradable and biocompatible block copolymer of Poly-lactic-co-glycolic acid and Poly-l-lysine improves functional recovery and reduces spinal cord tissue injury after spinal cord hemisection injury in rats. Here, we evaluated ...
DOI:
10.1016/j.biomaterials.2017.01.024

73. Can forest fragmentation and configuration work as indicators of human–wildlife conflict? Evidences from human death and injury by wildlife attacks in Nepal

Author:
Krishna Prasad Acharya; Prakash Kumar Paudel; Shant Raj Jnawali; Prem Raj Neupane; Michael Köhl
Source:
Ecological indicators 2017 v.80 pp. 74-83
ISSN:
1470-160X
Subject:
Elephas maximus; Panthera pardus; Panthera tigris tigris; Rhinoceros; animal injuries; death; forests; grasslands; habitat connectivity; habitat fragmentation; human population; human-wildlife relations; humans; landscapes; national surveys; population density; regression analysis; wildlife; Nepal
Abstract:
... Fragmented forests and heterogeneous landscapes are likely to have less natural vegetation and smaller core areas, a low degree of landscape connectivity, high prevalence of anthropogenic edges, and high landscape heterogeneity, which may alter—at varying degrees—behavior of wildlife species such as attacks on humans. We evaluated whether or not forest fragmentation (e.g. shape, size and distribut ...
DOI:
10.1016/j.ecolind.2017.04.037

74. Combined polymer-curcumin conjugate and ependymal progenitor/stem cell treatment enhances spinal cord injury functional recovery

Author:
Raquel Requejo-Aguilar; Ana Alastrue-Agudo; Marta Cases-Villar; Eric Lopez-Mocholi; Richard England; María J. Vicent; Victoria Moreno-Manzano
Source:
Biomaterials 2017 v.113 pp. 18-30
ISSN:
0142-9612
Subject:
animal injuries; animal models; bioavailability; blood; curcumin; humans; neuroprotective effect; spinal cord; stem cells; therapeutics
Abstract:
... Spinal cord injury (SCI) suffers from a lack of effective therapeutic strategies. Animal models of acute SCI have provided evidence that transplantation of ependymal stem/progenitor cells of the spinal cord (epSPCs) induces functional recovery, while systemic administration of the anti-inflammatory curcumin provides neuroprotection. However, functional recovery from chronic stage SCI requires addi ...
DOI:
10.1016/j.biomaterials.2016.10.032

75. Development of a clinical spasticity scale for evaluation of dogs with chronic thoracolumbar spinal cord injury

Author:
Melissa J. Lewis; Natasha J. Olby
Source:
American journal of veterinary research 2017 v.78 no.7 pp. 854-861
ISSN:
0002-9645
Subject:
animal injuries; clinical trials; dogs; gait; hindlimbs; humans; muscles; pain; spinal cord; temporal variation
Abstract:
... OBJECTIVE To develop a spasticity scale for dogs with chronic deficits following severe spinal cord injury (SCI) for use in clinical assessment and outcome measurement in clinical trials. ANIMALS 20 chronically paralyzed dogs with a persistent lack of hind limb pain perception caused by an acute SCI at least 3 months previously. PROCEDURES Spasticity was assessed in both hind limbs via tests of mu ...
DOI:
10.2460/ajvr.78.7.854

76. Intradiencephalon injection of histamine inhibited the recovery of locomotor function of spinal cord injured zebrafish

Author:
Shu-Bing Huang; Hou-De Zhao; Lin-Fang Wang; Meng-Fei Sun; Ying-Li Zhu; Yi-Bo Wu; Yi-Da Xu; Shi-Xiao Peng; Chun Cui; Yan-Qin Shen
Source:
Biochemical and biophysical research communications 2017 v.489 pp. 275-280
ISSN:
0006-291X
Subject:
Danio rerio; adults; animal injuries; animal models; fluorescent antibody technique; histamine; humans; insulin-like growth factor I; interleukin-1beta; neuroglia; neurotrophins; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; spinal cord; tumor necrosis factor-alpha
Abstract:
... Human spinal cord injury (SCI) usually causes irreversible disability beneath the injured site due to poor neural regeneration. On the contrary, zebrafish show significant regenerative ability after SCI, thus is usually worked as an animal model for studying neuroregeneration. Most of the previous SCI studies focused on the local site of SCI, the supraspinal-derived signals were rarely mentioned. ...
DOI:
10.1016/j.bbrc.2017.05.158

77. Local delivery of minocycline from metal ion-assisted self-assembled complexes promotes neuroprotection and functional recovery after spinal cord injury

Author:
Zhicheng Wang; Jia Nong; Robert B. Shultz; Zhiling Zhang; Taegyo Kim; Veronica J. Tom; Ravi K. Ponnappan; Yinghui Zhong
Source:
Biomaterials 2017 v.112 pp. 62-71
ISSN:
0142-9612
Subject:
animal injuries; anti-inflammatory agents; antioxidants; clinical trials; death; drug delivery systems; hepatotoxicity; humans; hydrocolloids; laboratory animals; metal ions; minocycline; neuroprotective effect; patients; spinal cord
Abstract:
... Many mechanisms contribute to the secondary injury cascades following traumatic spinal cord injury (SCI). However, most current treatment strategies only target one or a few elements in the injury cascades, and have been largely unsuccessful in clinical trials. Minocycline hydrochloride (MH) is a clinically available antibiotic and anti-inflammatory drug that has been shown to target a broad range ...
DOI:
10.1016/j.biomaterials.2016.10.002
PubMed:
27744221
PubMed Central:
PMC5120994

78. Proof of concept of a new autologous skin substitute for the treatment of deep wounds in dogs

Author:
L. Ramió-Lluch; S. Cerrato; P. Brazis; R.M. Rabanal; D. Fondevila; A. Puigdemont
Source:
veterinary journal 2017 v.230 pp. 36-40
ISSN:
1090-0233
Subject:
Beagle; animal injuries; bioengineering; biopsy; dogs; fibroblasts; histology; humans; keratinocytes; mice; models; skin (animal); veterinary clinics; xenotransplantation
Abstract:
... Autologous skin grafts are effective for the repair of large skin wounds, but the availability of large amounts of skin is often limited. Through bioengineering, several autologous skin substitutes have been developed for use in human clinical practice. However, few skin substitutes are available for use in animals. The aim of this study was to develop and assess an engineered autologous skin subs ...
DOI:
10.1016/j.tvjl.2017.11.003

79. The regulatory effect of electro-acupuncture on the expression of NMDA receptors in a SCI rat model

Author:
Wen-Zhan Tu; Wen-Ci Chen; Wan Xia; Rong He; Jie Hu; Ming-Chen Jiang; Song-He Jiang
Source:
Life sciences 2017 v.177 pp. 8-14
ISSN:
0024-3205
Subject:
Western blotting; animal injuries; animal models; calcium; cell death; fluorescent antibody technique; glutamate receptors; humans; neuroprotective effect; permeability; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; spinal cord
Abstract:
... In early spinal cord injury (SCI), glutamate receptors, including N-methyl-d-aspartate (NMDA) receptors (NMDARs), are over-stimulated by excessively released glutamate. The enhanced activity of NMDARs may cause cell death by overloading calcium (Ca2+) into cells based on their high permeability to Ca2+. Studies in SCI animals have shown that treatment with electro-acupuncture (EA) is able to reduc ...
DOI:
10.1016/j.lfs.2017.04.004

80. A quite rare case of bruising abrasion-like as gun entry wound

Author:
Carlos Chérrez Bermejo; Rafael Teijeira Álvarez
Source:
Forensic science international 2018 v.288 pp. e1
ISSN:
0379-0738
Subject:
animal injuries; forensic sciences; humans; suicide
Abstract:
... An interesting case of a suicide by a home made gun is described. A review of the literature is added. The entry wound is exceptional. The case shows that the forensic assessment of a home made gun case may be very difficult and implies to evaluate all the circumstances related to it. Specific forensic signs of home made gun injuries are suggested. ...
DOI:
10.1016/j.forsciint.2018.05.013

81. Compensation payments, procedures and policies towards human-wildlife conflict management: Insights from India

Author:
Krithi K. Karanth; Shriyam Gupta; Anubhav Vanamamalai
Source:
Biological conservation 2018 v.227 pp. 383-389
ISSN:
0006-3207
Subject:
animal injuries; conflict management; crop losses; death; human-wildlife relations; humans; issues and policy; livestock; monitoring; natural resources conservation; predation; wildlife management; India
Abstract:
... The effectiveness of compensation payments in mitigating and resolving human-wildlife conflict is globally debated. We examined procedures, types, and payments made for incidents reported in India from 2010 to 2015. Among India's 29 states, 22 (76%) compensated for crop loss, 18 (62%) for property damage, 26 (90%) for livestock depredation, and 28 (97%) for human injury or death. In 2012–2013, a t ...
DOI:
10.1016/j.biocon.2018.07.006

82. Mesenchymal stem cells encapsulated into biomimetic hydrogel scaffold gradually release CCL2 chemokine in situ preserving cytoarchitecture and promoting functional recovery in spinal cord injury

Author:
S. Papa; I. Vismara; A. Mariani; M. Barilani; S. Rimondo; M. De Paola; N. Panini; E. Erba; E. Mauri; F. Rossi; G. Forloni; L. Lazzari; P. Veglianese
Source:
Journal of controlled release 2018 v.278 pp. 49-56
ISSN:
0168-3659
Subject:
animal injuries; biomimetics; chemokine CCL2; evolution; humans; hydrogels; macrophages; models; motor neurons; neurodegenerative diseases; phenotype; rodents; sowing; spinal cord; stem cells
Abstract:
... Spinal cord injury (SCI) is an acute neurodegenerative disorder caused by traumatic damage of the spinal cord. The neuropathological evolution of the primary trauma involves multifactorial processes that exacerbate the pathology, worsening the neurodegeneration and limiting neuroregeneration. This complexity suggests that multi-therapeutic approaches, rather than any single treatment, might be mor ...
DOI:
10.1016/j.jconrel.2018.03.034

83. Perineurium-like sheath derived from long-term surviving mesenchymal stem cells confers nerve protection to the injured spinal cord

Author:
Yuan-Huan Ma; Xiang Zeng; Xue-Cheng Qiu; Qing-Shuai Wei; Ming-Tian Che; Ying Ding; Zhou Liu; Guo-Hui Wu; Jia-Hui Sun; Mao Pang; Li-Min Rong; Bin Liu; Zaid Aljuboori; Inbo Han; Eng-Ang Ling; Yuan-Shan Zeng
Source:
Biomaterials 2018 v.160 pp. 37-55
ISSN:
0142-9612
Subject:
allografting; animal injuries; antioxidants; axons; bone marrow; extracellular matrix; good manufacturing practices; humans; immunocytochemistry; mesenchymal stromal cells; models; nerve tissue; peripheral nerves; rats; secretion; spinal cord; transmission electron microscopy
Abstract:
... The functional multipotency enables mesenchymal stem cells (MSCs) promising translational potentials in treating spinal cord injury (SCI). Yet the fate of MSCs grafted into the injured spinal cord has not been fully elucidated even in preclinical studies, rendering concerns of their safety and genuine efficacy. Here we used a rat spinal cord transection model to evaluate the cell fate of allograft ...
DOI:
10.1016/j.biomaterials.2018.01.015

84. Reactivation of Dormant Relay Pathways in Injured Spinal Cord by KCC2 Manipulations

Author:
Bo Chen; Yi Li; Bin Yu; Zicong Zhang; Benedikt Brommer; Philip Raymond Williams; Yuanyuan Liu; Shane Vincent Hegarty; Songlin Zhou; Junjie Zhu; Hong Guo; Yi Lu; Yiming Zhang; Xiaosong Gu; Zhigang He
Source:
Cell 2018 v.174 no.3 pp. 521-535.e13
ISSN:
0092-8674
Subject:
agonists; animal injuries; axons; humans; innervation; interneurons; mice; paralysis; spinal cord
Abstract:
... Many human spinal cord injuries are anatomically incomplete but exhibit complete paralysis. It is unknown why spared axons fail to mediate functional recovery in these cases. To investigate this, we undertook a small-molecule screen in mice with staggered bilateral hemisections in which the lumbar spinal cord is deprived of all direct brain-derived innervation, but dormant relay circuits remain. W ...
DOI:
10.1016/j.cell.2018.06.005
PubMed:
30033363
PubMed Central:
PMC6063786

85. Stem cells from human apical papilla decrease neuro-inflammation and stimulate oligodendrocyte progenitor differentiation via activin-A secretion

Author:
Pauline De Berdt; Pauline Bottemanne; John Bianco; Mireille Alhouayek; Anibal Diogenes; Amy Llyod; Jose Gerardo-Nava; Gary A. Brook; Véronique Miron; Giulio G. Muccioli; Anne des Rieux
Source:
Cellular and molecular life sciences 2018 v.75 no.15 pp. 2843-2856
ISSN:
1420-682X
Subject:
adults; animal injuries; coculture; death; humans; mechanism of action; neuroprotective effect; oligodendroglia; patients; rats; secretion; spinal cord; stem cells; therapeutics; tissue degeneration; tissues; tumor necrosis factor-alpha
Abstract:
... Secondary damage following spinal cord injury leads to non-reversible lesions and hampering of the reparative process. The local production of pro-inflammatory cytokines such as TNF-α can exacerbate these events. Oligodendrocyte death also occurs, followed by progressive demyelination leading to significant tissue degeneration. Dental stem cells from human apical papilla (SCAP) can be easily obtai ...
DOI:
10.1007/s00018-018-2764-5

86. The human natural killer-1 (HNK-1) glycan mimetic ursolic acid promotes functional recovery after spinal cord injury in mouse

Author:
Sudhanshu Sahu; Rong Li; Praveen Kumar Kadeyala; Shisong Liu; Melitta Schachner
Source:
Journal of nutritional biochemistry 2018 v.55 pp. 219-228
ISSN:
0955-2863
Subject:
epitopes; anti-inflammatory activity; animal injuries; humans; inflammation; interleukin-6; rapamycin; mice; regrowth; tumor necrosis factor-alpha; animal models; spinal cord; neuroplasticity; ursolic acid; oral administration; myelination
Abstract:
... Human natural killer-1 (HNK-1) cell antigen is a glycan epitope involved in several neural events, such as neuritogenesis, myelination, synaptic plasticity and regeneration of the nervous system after injury. We have recently identified the small organic compound ursolic acid (UA) as a HNK-1 mimetic with the aim to test its therapeutic potential in the central nervous system. UA, a plant-derived p ...
DOI:
10.1016/j.jnutbio.2018.01.016

87. Towards rationally designed biomanufacturing of therapeutic extracellular vesicles: impact of the bioproduction microenvironment

Author:
Divya B. Patel; Marco Santoro; Louis J. Born; John P. Fisher; Steven M. Jay
Source:
Biotechnology advances 2018 v.36 no.8 pp. 2051-2059
ISSN:
0734-9750
Subject:
animal injuries; brain damage; cell culture; clinical trials; exosomes; humans; membrane bioreactors; myocardial infarction; osteoarthritis; spinal cord; therapeutics
Abstract:
... Extracellular vesicles (EVs), including exosomes, microvesicles, and others, have emerged as potential therapeutics for a variety of applications. Pre-clinical reports of EV efficacy in treatment of non-healing wounds, myocardial infarction, osteoarthritis, traumatic brain injury, spinal cord injury, and many other injuries and diseases demonstrate the versatility of this nascent therapeutic modal ...
DOI:
10.1016/j.biotechadv.2018.09.001
PubMed:
30218694
PubMed Central:
PMC6250573

88. Veterinary Neurologic Rehabilitation: The Rationale for a Comprehensive Approach

Author:
Lauren R. Frank; Patrick F.P. Roynard
Source:
Topics in companion animal medicine 2018 v.33 no.2 pp. 49-57
ISSN:
1938-9736
Subject:
acupuncture; analgesia; animal injuries; death; dogs; electrical treatment; etiology; gait; humans; inflammation; intervertebral disks; medicine; pain; patients; peripheral nervous system diseases; pets; physical therapy; protocols; sclerosis; spinal cord; surgery; veterinarians; veterinary medicine
Abstract:
... The increase in client willingness to pursue surgical procedures, the heightened perceived value of veterinary patients, and the desire to provide comprehensive medical care have driven the recent demand of using an integrative treatment approach in veterinary rehabilitation. Physical therapy following neurologic injury has been the standard of care in human medicine for decades, whereas similar r ...
DOI:
10.1053/j.tcam.2018.04.002

89. iPSC-derived neural precursor cells: potential for cell transplantation therapy in spinal cord injury

Author:
Narihito Nagoshi; Hideyuki Okano
Source:
Cellular and molecular life sciences 2018 v.75 no.6 pp. 989-1000
ISSN:
1420-682X
Subject:
animal injuries; animal models; cell transplantation; embryonic stem cells; epigenetics; ethics; humans; induced pluripotent stem cells; momentum; patients; somatic cells; spinal cord; transfection
Abstract:
... A number of studies have demonstrated that transplantation of neural precursor cells (NPCs) promotes functional recovery after spinal cord injury (SCI). However, the NPCs had been mostly harvested from embryonic stem cells or fetal tissue, raising the ethical concern. Yamanaka and his colleagues established induced pluripotent stem cells (iPSCs) which could be generated from somatic cells, and thi ...
DOI:
10.1007/s00018-017-2676-9

90. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002

91. Different functional bio-scaffolds share similar neurological mechanism to promote locomotor recovery of canines with complete spinal cord injury

Author:
Dingyang Liu; Xing Li; Zhifeng Xiao; Wen Yin; Yannan Zhao; Jun Tan; Bing Chen; Xingjun Jiang; Jianwu Dai
Source:
Biomaterials 2019 v.214 pp. 119230
ISSN:
0142-9612
Subject:
animal injuries; axons; bone marrow; dogs; hindlimbs; humans; models; paclitaxel; resection; rodents; spinal cord
Abstract:
... Many studies have shown that rodents exhibit a certain degree of spontaneous motor function recovery even if they suffer from spinal cord complete transection injury. However, the characteristics of spontaneous locomotor recovery and its associated neurobiological mechanisms are unclear. In this study, we observed that spontaneous locomotor function recovery of hind limbs could also be detected in ...
DOI:
10.1016/j.biomaterials.2019.119230

92. Human intracerebroventricular (ICV) injection of autologous, non-engineered, adipose-derived stromal vascular fraction (ADSVF) for neurodegenerative disorders: results of a 3-year phase 1 study of 113 injections in 31 patients

Author:
Christopher Duma; Oleg Kopyov; Alex Kopyov; Mark Berman; Elliot Lander; Michael Elam; Michael Arata; David Weiland; Ruslana Cannell; Chad Caraway; Sean Berman; Kristin Scord; Lian Stemler; Karlyssa Chung; Samuel Khoudari; Rory McRory; Chace Duma; Sawyer Farmer; Anthony Bravo; Christian Yassa; Ami Sanathara; Elisa Singh; Benjamin Rapaport
Source:
Molecular biology reports 2019 v.46 no.5 pp. 5257-5272
ISSN:
0301-4851
Subject:
acetaminophen; amyotrophic lateral sclerosis; animal injuries; brain; brain damage; cognition; dexamethasone; disease progression; humans; molecular biology; patients; sclerosis; stroke; temperature
Abstract:
... We have chosen to test the safety of human intracerebroventricular (ICV) brain injections of autologous non-genetically-modified adipose-derived stromal vascular fraction (ADSVF). In this IRB-approved trial, 24 patients received ICV ADSVF via an implanted reservoir between 5/22/14 and 5/22/17. Seven others were injected via their ventriculo-peritoneal shunts. Ten patients had Alzheimer’s disease ( ...
DOI:
10.1007/s11033-019-04983-5

93. Using marketing to fish‐down bigheaded carp (Hypophthalmichthys spp.) in the United States: Eliminating the negative brand name, “carp”

Author:
Thomas M. Keevin; James E. Garvey
Source:
Journal of applied ichthyology 2019 v.35 no.5 pp. 1141-1146
ISSN:
0175-8659
Subject:
Hypophthalmichthys molitrix; Hypophthalmichthys nobilis; animal injuries; boats; common names; control methods; death; ecosystems; fisheries; humans; marketing; mortality; population growth; rivers; Asia; United States
Abstract:
... Invasive bigheaded carp species (Hypophthalmichthys spp.) from Asia have experienced rapid range expansion and population explosions in rivers of the United States resulting in ecosystem damage currently being witnessed and documented by fishery biologists. In addition, silver carp (H. molitrix) present a danger of injury and death to unsuspecting boaters, water skiers or recreational fishers due ...
DOI:
10.1111/jai.13951

94. Aligned collagen scaffold combination with human spinal cord-derived neural stem cells to improve spinal cord injury repair

Author:
Yunlong Zou; Dezun Ma; He Shen; Yannan Zhao; Bai Xu; Yongheng Fan; Zheng Sun; Bing Chen; Weiwei Xue; Ya Shi; Zhifeng Xiao; Rui Gu; Jianwu Dai
Source:
Biomaterials science 2020 v.8 no.18 pp. 5145-5156
ISSN:
2047-4849
Subject:
animal injuries; biocompatible materials; cell growth; cell viability; collagen; humans; inflammation; neurons; spinal cord; therapeutics
Abstract:
... Neural stem/progenitor cell (NSPC)-based spinal cord injury (SCI) therapy is expected to bridge the lesion site by transplanting exogenous NSPCs for replacement of lost cells. The transplanted NSPCs produce a microenvironment conducive to neuronal regeneration, and ultimately, functional recovery. Although both human fetal brain- and spinal cord- derived NSPCs (hbNSPCs and hscNSPCs, respectively) ...
DOI:
10.1039/d0bm00431f

95. Frizzled 1 and Wnt1 as new potential therapeutic targets in the traumatically injured spinal cord

Author:
Pau González; Carlos González-Fernández; Yolanda Campos-Martín; Manuela Mollejo; Melissa Carballosa-Gautam; Alexander Marcillo; Michael Norenberg; Francisco Javier Rodríguez
Source:
Cellular and molecular life sciences 2020 v.77 no.22 pp. 4631-4662
ISSN:
1420-682X
Subject:
animal injuries; humans; immunohistochemistry; ligands; models; myelin sheath; neurons; protein synthesis; quantitative polymerase chain reaction; rats; spinal cord; therapeutics; wnt proteins
Abstract:
... Despite the experimental evidence pointing to a significant role of the Wnt family of proteins in physiological and pathological rodent spinal cord functioning, its potential relevance in the healthy and traumatically injured human spinal cord as well as its therapeutic potential in spinal cord injury (SCI) are still poorly understood. To get further insight into these interesting issues, we first ...
DOI:
10.1007/s00018-019-03427-4

96. Human embryonic stem cell-derived neural stem cells encapsulated in hyaluronic acid promotes regeneration in a contusion spinal cord injured rat

Author:
Masoumeh Zarei-Kheirabadi; Hoda Sadrosadat; Atiyeh Mohammadshirazi; Razieh Jaberi; Farzaneh Sorouri; Fahimeh Khayyatan; Sahar Kiani
Source:
International journal of biological macromolecules 2020 v.148 pp. 1118-1129
ISSN:
0141-8130
Subject:
animal injuries; cell viability; embryonic stem cells; encapsulation; humans; hyaluronic acid; hydrogels; neural stem cells; neurons; oligodendroglia; rats; spinal cord
Abstract:
... spinal cord injury (SCI) is a traumatic damage that can causes a loss of neurons around the lesion site and resulting in locomotor and sensory deficits. Currently, there is widely attempts in improvement of treatment strategy and cell delivering to the central nervous system (CNS). The usage of hyaluronic acid (HA), the main components of the ECM in CNS tissue and neural stem cells (NSCs) niche, i ...
DOI:
10.1016/j.ijbiomac.2020.01.219

97. Restoring the Sense of Touch Using a Sensorimotor Demultiplexing Neural Interface

Author:
Patrick D. Ganzer; Samuel C. Colachis; Michael A. Schwemmer; David A. Friedenberg; Collin F. Dunlap; Carly E. Swiftney; Adam F. Jacobowitz; Doug J. Weber; Marcia A. Bockbrader; Gaurav Sharma
Source:
Cell 2020 v.181 no.4 pp. 763-773.e12
ISSN:
0092-8674
Subject:
animal injuries; cortex; humans; motor cortex; muscles; spinal cord; touch (sensation)
Abstract:
... Paralyzed muscles can be reanimated following spinal cord injury (SCI) using a brain-computer interface (BCI) to enhance motor function alone. Importantly, the sense of touch is a key component of motor function. Here, we demonstrate that a human participant with a clinically complete SCI can use a BCI to simultaneously reanimate both motor function and the sense of touch, leveraging residual touc ...
DOI:
10.1016/j.cell.2020.03.054

98. TNFAIP8 influences the motor function in mice after spinal cord injury (SCI) through meditating inflammation dependent on AKT

Author:
Wen Xue; Wei Tan; Longjia Dong; Qian Tang; Feng Yang; Xuexing Shi; Dianming Jiang; Yaowen Qian
Source:
Biochemical and biophysical research communications 2020 v.528 no.1 pp. 234-241
ISSN:
0006-291X
Subject:
animal injuries; cell viability; cytokines; humans; immunity; inflammation; lipopolysaccharides; mice; morbidity; necrosis; neoplasms; neurons; research; therapeutics; transfection
Abstract:
... Spinal cord injury (SCI) is a devastating disease and causes tissue loss and neurologic dysfunction, contributing to high morbidity and disability among human. However, the underlying molecular mechanisms still remain unclear. Tumor necrosis factor-α-induced protein 8 (TNFAIP8) is a member of the TNFAIP8/TIPE family, and has been implicated in different diseases associated with inflammation, infec ...
DOI:
10.1016/j.bbrc.2020.05.029

99. Dual-enzymatically cross-linked gelatin hydrogel enhances neural differentiation of human umbilical cord mesenchymal stem cells and functional recovery in experimental murine spinal cord injury

Author:
Minghao Yao; Jinrui Li; Junni Zhang; Shanshan Ma; Luyu Wang; Feng Gao; Fangxia Guan
Source:
Journal of materials chemistry B 2021 v.9 no.2 pp. 440-452
ISSN:
2050-7518
Subject:
animal injuries; apoptosis; cell viability; crosslinking; galactose oxidase; gelatin; histology; humans; hydrogels; hydrogen; inflammation; mice; models; nerve regeneration; neurogenesis; neurons; peroxidase; stem cells; therapeutics; umbilical cord
Abstract:
... Recently, an advanced stem cell and tissue engineering approach has been recognized as an emerging and fascinating strategy to promote neural repair in spinal cord injury (SCI). Hydrogels can be properly engineered to encapsulate cells, enhance cell viability and neural differentiation, and provide the advantage of flexible adaptation to irregular defects. In this study, a dual-enzymatically cross ...
DOI:
10.1039/d0tb02033h

100. HUCMSCs transplantation combined with ultrashort wave therapy attenuates neuroinflammation in spinal cord injury through NUR77/ NF-κB pathway

Author:
Shuai Wang; Yiying Jia; Xiangyan Cao; Sining Feng; Li Na; Hongxuan Dong; Jian Gao; Lixin Zhang
Source:
Life sciences 2021 v.267 pp. 118958
ISSN:
0024-3205
Subject:
animal injuries; astrocytes; humans; interleukin-6; rats; therapeutics; umbilical cord
Abstract:
... Spinal cord injury (SCI) is a major cause of long-term physical impairment. Currently, treatment for SCI is limited to supportive measures, which can lead to permanent disability, representing a serious social burden. The present study aimed to evaluate the inflammatory microenvironment effects of human umbilical cord mesenchymal stem cells (HUCMSCs)+ Ultrashort Wave (USW) therapy on SCI and revea ...
DOI:
10.1016/j.lfs.2020.118958