Subject term: humans and functional properties

1. 3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV pili

Author:: Helaine, Sophie; Dyer, David H.; Nassif, Xavier; Pelicic, Vladimir; Forest, Katrina T.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.40 pp. 15888-15893
ISSN:: 0027-8424
Subject:: Neisseria meningitidis; X-ray diffraction; adhesion; fimbriae; functional properties; humans; mechanism of action; models; organelles; peptidases; phenotype; proteins; virulence
Abstract:: ... Type IV pili (Tfp) are widespread filamentous bacterial organelles that mediate multiple virulence-related phenotypes. They are composed mainly of pilin subunits, which are processed before filament assembly by dedicated prepilin peptidases. Other proteins processed by these peptidases, whose molecular nature and mode of action remain enigmatic, play critical roles in Tfp biology. We have performe ...
DOI:: 10.1073/pnas.0707581104
PubMed:: 17893339
PubMed Central:: PMC2000383
: https://doi.org/10.1073/pnas.0707581104

2. 71. Cryopreservation of in vitroshoot-tips of a sweet potato Famaillá 6 clone (Ipomoea batatas (L.) Lam.) by droplet-vitrification technique

Author:: M.V. Rivero; A.M. Clausen; G. Monterubbianesi; A. Digilio
Source:: Cryobiology 2012 v.65 no.3 pp. 362
ISSN:: 0011-2240
Subject:: Ipomoea batatas; aluminum foil; anthocyanins; carotenoids; cryopreservation; disease prevention; ethylene glycol; exposure duration; functional properties; gene banks; genotype; germplasm; germplasm conservation; glycerol; humans; kinetin; labor force; micropropagation; minerals; nitrogen; risk; shoots; space and time; sucrose; sweet potatoes; temperature; vitamins; vitrification
Abstract:: ... Sweet potato varieties constitute a valuable germplasm as a source of carbohydrates, vitamins, fiber and minerals, with excellent functional properties in the prevention of diseases because of the presence of anthocyanins and carotenoids (Martí, 2008; CIP, 2009). The maintenance of germplasm in the field are under risk of losing material, high labor force, time and space consuming (Engelmann and E ...
DOI:: 10.1016/j.cryobiol.2012.07.071
: https://doi.org/10.1016/j.cryobiol.2012.07.071

3. A Peptide Derived from Bovine β-Casein Modulates Functional Properties of Bone Marrow-Derived Macrophages from Germfree and Human Flora-Associated Mice

Author:: Sandré, Catherine; Gleizes, Aude; Forestier, Françoise; Gorges-Kergot, Roseline; Chilmonczyk, Stefan; Léonil, Joëlle; Moreau, Marie-Christiane; Labarre, Colette
Source:: Journal of nutrition 2001 v.131 no.11 pp. 2936-2942
ISSN:: 0022-3166
Subject:: antigens; antimicrobial properties; beta-casein; bioassays; bone marrow; cattle; enzyme-linked immunosorbent assay; flora; flow cytometry; functional properties; humans; immunomodulation; interleukin-12; interleukin-1beta; lipopolysaccharides; macrophage colony-stimulating factor; macrophages; major histocompatibility complex; messenger RNA; mice; phagocytosis; reverse transcriptase polymerase chain reaction; secretion; tumor necrosis factor-alpha
Abstract:: ... The purpose of this study was to evaluate the immunomodulatory activity of a peptide derived from bovine β-casein (β-CN), the β-CN (193-209) peptide, on mouse macrophages that were obtained either from germfree (GF) or from human flora-associated (HF) mice. Macrophages were derived from bone marrow (BMDM) in the presence of recombinant macrophage colony-stimulating factor and exposed to the peptid ...

4. A Pursuit of the Functional Nutritional and Bioactive Properties of Canola Proteins and Peptides

Author:: Ayyappan Appukuttan Aachary; Usha Thiyam
Source:: Critical reviews in food science and nutrition 2012 v.52 no.11 pp. 965-979
ISSN:: 1549-7852
Subject:: animal source protein; bioactive properties; canola; canola meal; digestibility; foods; gelation; humans; peptides; proteins; water holding capacity
Abstract:: ... This review focuses on updated information about canola proteins and peptides, their functional, nutritional, and bioactive properties, safety aspects, and potential application in foods. Attention is paid to gelation, emulsion, thermal, and water holding capacities of crude and pure proteins and peptides isolated from canola meal. Various factors affecting these properties are discussed. This pap ...
DOI:: 10.1080/10408398.2010.516033
PubMed:: 22823345
: https://doi.org/10.1080/10408398.2010.516033

5. A Review on Osmotic Dehydration of Fruits and Vegetables: An Integrated Approach

Author:: V. Ramya; N. K. Jain
Source:: Journal of food process engineering 2017 v.40 no.3 pp. -
ISSN:: 0145-8876
Subject:: agitation; blanching; chemical elements; coatings; color; drying; electric field; energy; energy conservation; engineering; foods; fruits; functional properties; high pressure treatment; humans; mass transfer; mathematical models; mixing; nutrient content; odors; osmosis; osmotic treatment; solutes; temperature; texture; ultrasonic treatment; vegetables
Abstract:: ... Osmotic dehydration is a simultaneous mass transfer process which mainly promotes the flow of water molecules from the food to osmo‐active solution and some migration of solutes from the solution into the food, thus maintaining good organoleptic and functional properties in the finished product. This paper presents mechanism of osmotic dehydration and recent developments regarding the factors affe ...
DOI:: 10.1111/jfpe.12440
: https://doi.org/10.1111/jfpe.12440

6. A Tn antigen binding lectin from Myrsine coriacea displays toxicity in human cancer cell lines

Author:: Andrea Medeiros; Nora Berois; Marcelo Incerti; Sylvie Bay; Laura Franco Fraguas; Eduardo Osinaga
Source:: Natural medicines 2013 v.67 no.2 pp. 247-254
ISSN:: 1340-3443
Subject:: Myrsine; antigens; functional properties; glycosylation; humans; lectins; lymphocytes; molecular weight; toxicity
Abstract:: ... The Tn antigen (GalNAc-O-Ser/Thr) is one of the most specific human cancer-associated structures. In the present study we characterize the biochemical and functional properties of the Myrsine coriacea lectin (McL). We show that McL is an unusual high molecular weight highly glycosylated protein, which displays a strong Tn binding activity. The lectin exhibits in vitro inhibition of proliferation i ...
DOI:: 10.1007/s11418-012-0671-x
PubMed:: 22645079
: https://doi.org/10.1007/s11418-012-0671-x

7. A bacterial 2[4Fe4S] ferredoxin as redox partner of the plastidic-type ferredoxin-NADP+ reductase from Leptospira interrogans

Author:: Arleth S. López Rivero; Ma. Agustina Rossi; Eduardo A. Ceccarelli; Daniela L. Catalano-Dupuy
Source:: Biochimica et biophysica acta 2019 v.1863 no.4 pp. 651-660
ISSN:: 0304-4165
Subject:: Leptospira interrogans; bacteria; biochemical pathways; electrons; ferredoxin-NADP reductase; ferredoxins; functional properties; gene overexpression; genes; humans; mitochondria; models; mutagenesis; plastids
Abstract:: ... Ferredoxins are small iron-sulfur proteins that participate as electron donors in various metabolic pathways. They are recognized substrates of ferredoxin-NADP+ reductases (FNR) in redox metabolisms in mitochondria, plastids, and bacteria. We previously found a plastidic-type FNR in Leptospira interrogans (LepFNR), a parasitic bacterium of animals and humans. Nevertheless, we did not identify plan ...
DOI:: 10.1016/j.bbagen.2019.01.004
: https://doi.org/10.1016/j.bbagen.2019.01.004

8. A biological trait approach to assess the functional composition of subtidal benthic communities in an estuarine ecosystem

Author:: Pieter van der Linden; Joana Patrício; Agnese Marchini; Núria Cid; João Magalhães Neto; João Carlos Marques
Source:: Ecological indicators 2012 v.20 no. pp. 121-133
ISSN:: 1470-160X
Subject:: ecosystems; estuaries; functional diversity; functional properties; humans; invertebrates; salinity; species diversity; Portugal
Abstract:: ... Within transitional/estuarine environments ‘ecosystem functioning’ has been mostly investigated with “traditional” taxonomic analysis, based on the taxonomic composition of benthic invertebrate communities. However, ‘ecosystem functioning’ depends also greatly on the functional characteristics (biological traits) of organisms. It was a priori suggested that the biological traits of the subtidal be ...
DOI:: 10.1016/j.ecolind.2012.02.004
: https://doi.org/10.1016/j.ecolind.2012.02.004

9. A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network

Author:: Elena V. Ignatieva; Dmitry A. Afonnikov; Olga V. Saik; Evgeny I. Rogaev; Nikolay A. Kolchanov
Source:: BMC genetics 2016 v.17 no.Supplement 3 pp. 158
ISSN:: 1471-2156
Subject:: G-protein coupled receptors; Mendelian inheritance; binding proteins; body weight changes; brain; cytokines; feeding behavior; functional properties; genes; humans; insulin; lipids; meta-analysis; morphogenesis; neuropeptides; obesity; phosphotransferases (kinases); risk estimate; signal transduction; tissues; transcription (genetics); transcription factors
Abstract:: ... BACKGROUND: Obesity is heritable. It predisposes to many diseases. The objectives of this study were to create a compendium of genes relevant to feeding behavior (FB) and/or body weight (BW) regulation; to construct and to analyze networks formed by associations between genes/proteins; and to identify the most significant genes, biological processes/pathways, and tissues/organs involved in BW regu ...
DOI:: 10.1186/s12863-016-0466-2
PubMed:: 28105929
PubMed Central:: PMC5249002
: https://doi.org/10.1186/s12863-016-0466-2

10. A compendium on single‐cell analysis for the curious

Author:: Caroline J. Gallant; Ulf Landegren
Source:: FEBS journal 2019 v.286 no.8 pp. 1442-1444
ISSN:: 1742-464X
Subject:: functional properties; humans; medicine; research programs; therapeutics
Abstract:: ... Single‐cell analysis is impacting biology and medicine by changing the scale and resolution at which we investigate multicellular organisms. A particular, overarching aim of this field is to characterize the programmed development of all different cell types in the human body, as well as their individual spatial, molecular, and functional characteristics. This vast research program is generating a ...
DOI:: 10.1111/febs.14820
: https://doi.org/10.1111/febs.14820

11. A functionally conserved member of the FTZâF1 nuclear receptor family from Schistosoma mansoni

Author:: Ricardo L de MendonÃ§a; Didier Bouton; Benjamin Bertin; Hector Escriva; Christophe NoÃ«l; JeanâMarc Vanacker; Jocelyne Cornette; Vincent Laudet; Raymond J. Pierce
Source:: European journal of biochemistry 2002 v.269 no.22 pp. 5700-5711
ISSN:: 0014-2956
Subject:: DNA-binding domains; Danio rerio; Drosophila; Schistosoma mansoni; adults; cercariae; exons; functional properties; humans; invertebrates; larvae; males; messenger RNA; miracidia; mutants; parasites; phylogeny; protein synthesis; receptors; reporter genes; sexual development; transcription (genetics)
Abstract:: ... The fushi tarazu factor 1 (FTZâF1) nuclear receptor subfamily comprises orphan receptors with crucial roles in development and sexual differentiation in vertebrates and invertebrates. We describe the structure and functional properties of an FTZâF1 from the platyhelminth parasite of humans, Schistosoma mansoni, the first receptor from this family to be characterized in a Lophotrochozoan. It co ...
DOI:: 10.1046/j.1432-1033.2002.03287.x
: https://doi.org/10.1046/j.1432-1033.2002.03287.x

12. A microfluidically perfused three dimensional human liver model

Author:: Knut Rennert; Sandra Steinborn; Marko Gröger; Birgit Ungerböck; Anne-Marie Jank; Josef Ehgartner; Sandor Nietzsche; Julia Dinger; Michael Kiehntopf; Harald Funke; Frank T. Peters; Amelie Lupp; Claudia Gärtner; Torsten Mayr; Michael Bauer; Otmar Huber; Alexander S. Mosig
Source:: Biomaterials 2015 v.71 pp. 119-131
ISSN:: 0142-9612
Subject:: biochemical pathways; coculture; endothelial cells; functional properties; hepatocytes; humans; liver; macrophages; microvilli; models; nutrition; oxygen consumption; secretion; transferrin; transport proteins
Abstract:: ... Within the liver, non-parenchymal cells (NPCs) are critically involved in the regulation of hepatocyte polarization and maintenance of metabolic function. We here report the establishment of a liver organoid that integrates NPCs in a vascular layer composed of endothelial cells and tissue macrophages and a hepatic layer comprising stellate cells co-cultured with hepatocytes. The three-dimensional ...
DOI:: 10.1016/j.biomaterials.2015.08.043
: https://doi.org/10.1016/j.biomaterials.2015.08.043

13. A newly isolated probiotic Enterococcus faecalis strain from vagina microbiota enhances apoptosis of human cancer cells

Author:: Y. Nami; N. Abdullah; B. Haghshenas; D. Radiah; R. Rosli; A. Yari Khosroushahi
Source:: Journal of applied microbiology 2014 v.117 no.2 pp. 498-508
ISSN:: 1364-5072
Subject:: Enterococcus faecalis; adverse effects; anti-infective properties; antibiotic resistance; antineoplastic agents; apoptosis; bacteria; bile resistance; cytotoxicity; functional properties; gastrointestinal system; genes; humans; metabolites; probiotics; proteins; vagina; women
Abstract:: ... AIMS: This study aimed to describe probiotic properties and bio‐therapeutic effects of newly isolated Enterococcus faecalis from the human vaginal tract. METHODS AND RESULTS: The Enterococcus faecalis strain was originally isolated from the vaginal microbiota of Iranian women and was molecularly identified using 16SrDNA gene sequencing. Some biochemical methodologies were preliminarily used to cha ...
DOI:: 10.1111/jam.12531
: https://doi.org/10.1111/jam.12531

14. A novel Kir7.1 splice variant expressed in various mouse tissues shares organisational and functional properties with human Leber amaurosis-causing mutations of this K+ channel

Author:: Erwin Vera; Isabel Cornejo; Johanna Burgos; María Isabel Niemeyer; Francisco V. Sepúlveda; L. Pablo Cid
Source:: Biochemical and biophysical research communications 2019 v.514 no.3 pp. 574-579
ISSN:: 0006-291X
Subject:: choroid plexus; epithelium; functional properties; human cell lines; humans; kidneys; lungs; mice; mutation; permeability; plasma membrane; potassium channels; proteasome endopeptidase complex; retinal diseases; sodium-potassium-exchanging ATPase; vision
Abstract:: ... Kir7.1 is an inwardly rectifying K+ channel present in epithelia where it shares membrane localization with the Na+/K+-pump. In the present communication we report the presence of a novel splice variant of Kir7.1 in mouse tissues including kidney, lung, choroid plexus and retinal pigment epithelium (RPE). The variant named mKir7.1-SV2 lacks most of the C-terminus domain but is predicted to have th ...
DOI:: 10.1016/j.bbrc.2019.04.169
: https://doi.org/10.1016/j.bbrc.2019.04.169

15. A novel bovine serum albumin and sodium alginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defects repair

Author:: Huifang Yuan; Xiaoyan Zheng; Wan Liu; Hui Zhang; Jingjing Shao; Jiaxin Yao; Chunyi Mao; Junfeng Hui; Daidi Fan
Source:: Colloids and surfaces 2020 v.192 pp. 111041
ISSN:: 0927-7765
Subject:: bioactive properties; biocompatibility; biocompatible materials; biomimetics; bone marrow; bovine serum albumin; cartilage; functional properties; humans; hydrogels; hydroxyapatite; in vivo studies; mesenchymal stromal cells; nanowires; porosity; sodium alginate; strength (mechanics); tissue engineering
Abstract:: ... Cartilage tissue engineering has become the trend of cartilage defect repair owing to the engineered biomimetic tissue that can mimic the structural, biological and functional characteristics of natural cartilage. Biomaterials with high biocompatibility and regeneration capacity are expected to be used in cartilage tissue engineering. Herein, in this study, a dual-network bovine serum albumin/sodi ...
DOI:: 10.1016/j.colsurfb.2020.111041
: https://doi.org/10.1016/j.colsurfb.2020.111041

16. A novel non-integrative single-cycle chimeric HIV lentivector DNA vaccine

Author:: Maha Moussa; Géraldine Arrode-Brusés; Iliyan Manoylov; Alexander Malogolovkin; Dimitri Mompelat; Honorine Ishimwe; Amel Smaoune; Bilel Ouzrout; Jean Gagnon; Yahia Chebloune
Source:: Vaccine 2015 v.33 no.19 pp. 2273-2282
ISSN:: 0264-410X
Subject:: Caprine arthritis encephalitis virus; DNA; Human immunodeficiency virus 1; animal models; antigens; cell culture; functional properties; gene expression; genes; goats; humans; immune response; immunization; mice; protein synthesis; recombinant vaccines; splenocytes; viral proteins; virion; viruses
Abstract:: ... Novel HIV vaccine vectors and strategies are needed to control HIV/AIDS epidemic in humans and eradicate the infection. DNA vaccines alone failed to induce immune responses robust enough to control HIV-1. Development of lentivirus-based DNA vaccines deficient for integration and with a limited replication capacity is an innovative and promising approach. This type of vaccine mimics the early stage ...
DOI:: 10.1016/j.vaccine.2015.03.021
: https://doi.org/10.1016/j.vaccine.2015.03.021

17. A novel splice variant of supervillin, SV5, promotes carcinoma cell proliferation and cell migration

Author:: Xueran Chen; Haoran Yang; Shangrong Zhang; Zhen Wang; Fang Ye; Chaozhao Liang; Hongzhi Wang; Zhiyou Fang
Source:: Biochemical and biophysical research communications 2017 v.482 pp. 43-49
ISSN:: 0006-291X
Subject:: RNA interference; actin; cell movement; cell proliferation; exons; functional properties; humans; mice; myocardium; myosin; neoplasm cells; neoplasms; smooth muscle; striated muscle
Abstract:: ... Supervillin is an actin-associated protein that regulates actin dynamics by interacting with Myosin II, F-actin, and Cortactin to promote cell contractility and cell motility. Two splicing variants of human Supervillin (SV1 and SV4) have been reported in non-muscle cells; SV1 lacks 3 exons present in the larger isoform SV4. SV2, also called archvillin, is present in striated muscle; SV3, also call ...
DOI:: 10.1016/j.bbrc.2016.11.013
: https://doi.org/10.1016/j.bbrc.2016.11.013

18. A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods

Author:: Lilis Nuraida
Source:: Food science and human wellness 2015 v.4 no.2 pp. 47-55
ISSN:: 2213-4530
Subject:: Enterococcus; Lactobacillus; Leuconostoc; Pediococcus; buffalo milk; cholesteremic effect; diarrhea; fermented foods; functional properties; health promotion; human health; humans; immune system; in vitro studies; lactic acid bacteria; probiotics; starter cultures
Abstract:: ... Traditional Indonesian fermented foods can be used as potential sources of probiotics as they commonly contain lactic acid bacteria (LAB), including species of Lactobacillus, Pediococcus, Enterococcus, Weisella and Leuconostoc. The occurrence of LAB in Indonesian fermented foods is not only limited to lactic fermented foods but is also present in foods with molds as the main starter culture. This ...
DOI:: 10.1016/j.fshw.2015.06.001
: https://doi.org/10.1016/j.fshw.2015.06.001

19. A simple method of surface functionalisation for immuno-specific immobilisation of proteins

Author:: Kengne-Momo, R. P.; Jeyachandran, Y. L.; Assaf, A.; Esnault, C.; Daniel, P.; Pilard, J. F.; Durand, M. J.; Lagarde, F.; Dongo, E.; Thouand, G.
Source:: Analytical and bioanalytical chemistry 2010 v.398 no.3 pp. 1249-1255
ISSN:: 1618-2642
Subject:: Raman spectroscopy; electrochemistry; functional properties; gold; humans; immunoglobulin G; quartz
Abstract:: ... We present a new and advanced methodology, developed for surface functionalisation of gold and to study immobilisation of an immuno-specific system of proteins. A combination of electrochemical quartz crystal microbalance and Raman spectroscopy techniques allowed a complete understanding of the system starting from surface functionalisation and progressing to the functional structure analysis of i ...
DOI:: 10.1007/s00216-010-4032-x
PubMed:: 20683585
: https://doi.org/10.1007/s00216-010-4032-x

20. AIDS-protective HLA-B27/B57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz

Author:: de Groot, Natasja G.; Heijmans, Corrine M.C.; Zoet, Yvonne M.; de Ru, Arnoud H.; Verreck, Frank A.; van Veelen, Peter A.; Drijfhout, Jan W.; Doxiadis, Gaby G.M.; Remarque, Edmond J.; Doxiadis, Ilias I.N.; van Rood, Jon J.; Koning, Frits; Bontrop, Ronald E.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.34 pp. 15175-15180
ISSN:: 0027-8424
Subject:: HIV infections; HIV long-term survivors; Pan troglodytes; functional properties; humans; immune response; pandemic
Abstract:: ... In the absence of treatment, most HIV-1-infected humans develop AIDS. However, a minority are long-term nonprogressors, and resistance is associated with the presence of particular HLA-B*27/B*57 molecules. In contrast, most HIV-1-infected chimpanzees do not contract AIDS. In comparison with humans, chimpanzees experienced an ancient selective sweep affecting the MHC class I repertoire. We have det ...
DOI:: 10.1073/pnas.1009136107
PubMed:: 20696916
PubMed Central:: PMC2930537
: https://doi.org/10.1073/pnas.1009136107

21. Advances in Studies Using Vegetable Wastes to Obtain Pectic Substances: A Review

Author:: Flávia Roberta Buss Marenda; Fernanda Mattioda; Ivo Mottin Demiate; Alicia de Francisco; Carmen Lúcia de Oliveira Petkowicz; Maria Helene Giovanetti Canteri; Renata Dias de Mello Castanho Amboni
Source:: Journal of polymers and the environment 2019 v.27 no.3 pp. 549-560
ISSN:: 1566-2543
Subject:: acetylation; analgesic effect; chemical structure; drug formulations; economic investment; esterification; foods; functional properties; galacturonic acid; humans; in vivo studies; industry; mechanism of action; molecular weight; pectins; raw materials; vegetable residues
Abstract:: ... Vegetable waste represents a serious environmental problem for industries; however, it is also a valuable source of pectic substances. This paper aims to highlight the advances that have been made through studies regarding pectic substances from vegetable wastes, as well as providing an overview of the chemical structure of pectin, extraction and characterisation techniques, and potential applicat ...
DOI:: 10.1007/s10924-018-1355-8
: https://doi.org/10.1007/s10924-018-1355-8

22. Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans

Author:: Xin Zhou; Janet E. McElhaney
Source:: Vaccine 2011 v.29 no.11 pp. 2169-2177
ISSN:: 0264-410X
Subject:: CD4-positive T-lymphocytes; CD8-positive T-lymphocytes; cell-mediated immunity; elderly; functional properties; humans; influenza; pandemic; vaccines; young adults
Abstract:: ... Age-dependent changes in the cellular immune response have been mainly described in CD8+ T cells, with relative sparing of CD4+ T cells. We show that in older compared to young adults, effector memory and effector CD8+ T-cell subsets responding to influenza A/H3N2 challenge have diminished cytolytic activity. In contrast, effector CD4+ T-cell subsets in older adults share similar phenotypic and fu ...
DOI:: 10.1016/j.vaccine.2010.12.029
PubMed:: 21353149
PubMed Central:: PMC3057414
: https://doi.org/10.1016/j.vaccine.2010.12.029

23. Alginate/PVA Beads for Levan Production by Zymomonas mobilis

Author:: Marina F. S. Lorenzetti; Marina R. Moro; Crispin H. García‐Cruz
Source:: Journal of food process engineering 2015 v.38 no.1 pp. 31-36
ISSN:: 0145-8876
Subject:: Zymomonas mobilis; absorption; bacteria; biopolymers; body fat; body weight; calcium; dietary fiber; emulsifiers; encapsulation; fermentation; flavor; food industry; functional properties; gelation; humans; iron; levan; magnesium; microbial contamination; odors; pH; polyvinyl alcohol; processed foods; rats; rheological properties; risk reduction; sucrose; temperature; texture; yogurt; zinc
Abstract:: ... The levan is a biopolymer of great importance to the food industry since it is capable of defining and modifying the structure of one food, acting as stabilizer, thickener, gelling agent and being largely responsible for the texture of processed foods. The levan production by bacterial cell immobilization may potentialize the results of these studies, having advantages such as: high cell concentra ...
DOI:: 10.1111/jfpe.12123
: https://doi.org/10.1111/jfpe.12123

24. Altered response of fibroblasts from human tympanosclerotic membrane to interacting mast cells: Implication for tissue remodeling

Author:: Tadeusz Pawelczyk; Monika Sakowicz-Burkiewicz; Martyna Wesserling; Marzena Grden; Jerzy Kuczkowski
Source:: international journal of biochemistry & cell biology 2014 v.57 pp. 35-44
ISSN:: 1357-2725
Subject:: coculture; collagen; crosslinking; fibroblasts; fibrosis; functional properties; gelatinase B; histology; humans; immunoglobulin E; interleukin-6; mast cells; otitis media; pathogenesis; transforming growth factor beta 1; tumor necrosis factor-alpha
Abstract:: ... Several lines of evidence suggest that a tympanosclerotic (TMS) lesion often develops secondary to acute and chronic otitis media. Histological findings indicate that fibroblasts and inflammatory cells, including mast cells, play a key role in the tympanosclerotic plaque formation. However, details on the functional characteristics of tympanosclerotic fibroblasts (FsᵀᴹS) are scanty. Therefore the ...
DOI:: 10.1016/j.biocel.2014.10.002
: https://doi.org/10.1016/j.biocel.2014.10.002

25. An overview of plant-autochthonous microorganisms and fermented vegetable foods

Author:: Sebastian Torres; Hernán Verón; Luciana Contreras; Maria I. Isla
Source:: Food science and human wellness 2020 v.9 no.2 pp. 112-123
ISSN:: 2213-4530
Subject:: beverages; fermentation; fermented vegetables; fruits; functional properties; human health; humans; microorganisms; plant-based foods; shelf life; starter cultures; vegetables
Abstract:: ... Fermented plant-based foods and beverages constitute foods of high nutritional and functional value with appreciated health beneficial effects. They represent a natural and sustainable alternative to counteract the large wastage of vegetables and fruits due to their short shelf life. Usually, the use of controlled fermentation process using autochthonous microorganisms adapted to their vegetable m ...
DOI:: 10.1016/j.fshw.2020.02.006
: https://doi.org/10.1016/j.fshw.2020.02.006

26. An overview of separation methods in starch analysis: The importance of size exclusion chromatography and field flow fractionation

Author:: Heinrich RÃ¼bsam; Martin Krottenthaler; Martina Gastl; Thomas Becker
Source:: StaÌrke = 2012 v.64 no.9 pp. 683-695
ISSN:: 0038-9056
Subject:: fractionation; energy; humans; industry; starch; ultracentrifugation; gel chromatography; processed foods; biofuels; functional properties
Abstract:: ... Starch is the most important source of human food energy and also an important polymer for biofuels, processed food, and pharmaceutical industries. Precise determination of structural and functional properties of starch has been an outstanding factor for the improvement of dissolution and degradation processes, which are important procedures for commercial applications. Distinct separation techniq ...
DOI:: 10.1002/star.201100188
: https://doi.org/10.1002/star.201100188

27. Analysis of CD161 expression on human CD8⁺ T cells defines a distinct functional subset with tissue-homing properties

Author:: Billerbeck, Eva; Kang, Yu-Hoi; Walker, Lucy; Lockstone, Helen; Grafmueller, Stefanie; Fleming, Vicki; Flint, Jonathan; Willberg, Chris B.; Bengsch, Bertram; Seigel, Bianca; Ramamurthy, Narayan; Zitzmann, Nicole; Barnes, Eleanor J.; Thevanayagam, Jonarthan; Bhagwanani, Anisha; Leslie, Alasdair; Oo, Ye H.; Kollnberger, Simon; Bowness, Paul; Drognitz, Oliver; Adams, David H.; Blum, Hubert E.; Thimme, Robert; Klenerman, Paul
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.7 pp. 3006-3011
ISSN:: 0027-8424
Subject:: CCR2 receptor; CCR6 receptor; CD8-positive T-lymphocytes; CXCR6 receptor; Hepatitis C virus; arthritis; chronic hepatitis; functional properties; humans; inflammation; interferon-gamma; interleukin-17; interleukin-18; lectins; pathogenesis; transcription factors; viruses
Abstract:: ... CD8⁺ T lymphocytes play a key role in host defense, in particular against important persistent viruses, although the critical functional properties of such cells in tissue are not fully defined. We have previously observed that CD8⁺ T cells specific for tissue-localized viruses such as hepatitis C virus express high levels of the C-type lectin CD161. To explore the significance of this, we examine ...
DOI:: 10.1073/pnas.0914839107
PubMed:: 20133607
PubMed Central:: PMC2840308
: https://doi.org/10.1073/pnas.0914839107

28. Analysis of Calcium Transients and Uniaxial Contraction Force in Single Human Embryonic Stem Cell-Derived Cardiomyocytes on Microstructured Elastic Substrate with Spatially Controlled Surface Chemistries

Author:: Grespan Eleonora; Martewicz Sebastian; Serena Elena; Le Houerou Vincent; Rühe Jürgen; Elvassore Nicola
Source:: Langmuir 2016 v.32 no.46 pp. 12190-12201
ISSN:: 1520-5827
Subject:: calcium; cardiomyocytes; cell growth; contractile proteins; drugs; evolution; finite element analysis; fluorescence microscopy; functional properties; humans; models; photochemistry; screening
Abstract:: ... The mechanical activity of cardiomyocytes is the result of a process called excitation–contraction coupling (ECC). A membrane depolarization wave induces a transient cytosolic calcium concentration increase that triggers activation of calcium-sensitive contractile proteins, leading to cell contraction and force generation. An experimental setup capable of acquiring simultaneously all ECC features ...
DOI:: 10.1021/acs.langmuir.6b03138
: https://doi.org/10.1021/acs.langmuir.6b03138

29. Analysis of Single-Nucleotide Polymorphisms in Human Voltage-Gated Ion Channels

Author:: Katerina C. Nastou; Michail A. Batskinis; Zoi I. Litou; Stavros J. Hamodrakas; Vassiliki A. Iconomidou
Source:: Journal of proteome research 2019 v.18 no.5 pp. 2310-2320
ISSN:: 1535-3907
Subject:: amino acid sequences; arginine; cysteine; databases; electric potential difference; functional properties; genetic variation; glutamine; histidine; humans; ion channels; membrane potential; phenotype; proteome; single nucleotide polymorphism; statistical analysis; topology; transmembrane proteins
Abstract:: ... Voltage-gated ion channels (VGICs) are one of the largest groups of transmembrane proteins. Due to their major role in the generation and propagation of electrical signals, VGICs are considered important from a medical viewpoint, and their dysfunction is often associated with Channelopathies. We identified disease-associated mutations and polymorphisms in these proteins through mapping missense si ...
DOI:: 10.1021/acs.jproteome.9b00121
: https://doi.org/10.1021/acs.jproteome.9b00121

30. Analysis of adenovirus-induced immunity to infection with Listeria monocytogenes: Fading protection coincides with declining CD8 T cell numbers and phenotypic changes

Author:: Marie Louise Jahn; Maria Abildgaard Steffensen; Jan Pravsgaard Christensen; Allan Randrup Thomsen
Source:: Vaccine 2018 v.36 no.20 pp. 2825-2832
ISSN:: 0264-410X
Subject:: CD8-positive T-lymphocytes; Listeria monocytogenes; antigens; functional properties; glycoproteins; humans; immunity; longevity; phenotype; phenotypic plasticity; serotypes; vaccination; vaccines
Abstract:: ... Defining correlates of T cell mediated protection is important in order to accelerate the development of efficient T cell based vaccines conferring long-term immunity.Extensive studies have provided important insight regarding the characteristics and functional properties of the effector and memory CD8 T cells induced by viral vector based vaccines. However, long-term protection has been difficult ...
DOI:: 10.1016/j.vaccine.2018.03.080
: https://doi.org/10.1016/j.vaccine.2018.03.080

31. Analysis of functional properties of biologically active substances using eukaryotic cell models (review)

Author:: K. V. Lisitskaya; I. V. Nikolaev; A. A. Torkova; V. O. Popov; O. V. Koroleva
Source:: Applied biochemistry and microbiology 2012 v.48 no.6 pp. 525-540
ISSN:: 0003-6838
Subject:: bioactive properties; cell culture; chemoprevention; eukaryotic cells; functional properties; humans; models; prebiotics
Abstract:: ... This work presents an analysis of current data on the investigation into the functional properties of biologically active substances in model systems based on cultivated human cells. The knowledge regarding the practical application of cell cultures for the analysis of functional properties of bioactive substances is summarized, including antioxidant, immunomodulating, pro- and prebiotics, and che ...
DOI:: 10.1134/S0003683812060087
: https://doi.org/10.1134/S0003683812060087

32. Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics

Author:: Claire Horlock; Farouk Shakib; Jafar Mahdavi; Nick S Jones; Herb F Sewell; Amir M Ghaemmaghami
Source:: Genome biology 2007 v.8 no.3 pp. 1512
ISSN:: 1474-760X
Subject:: actin; adaptive immunity; blood; cell growth; cytochrome c; cytokines; dendritic cells; enzyme-linked immunosorbent assay; fibrinogen; functional properties; functional status; humans; immunological synapse; models; phenotype; proteomics
Abstract:: ... BACKGROUND: Dendritic cells (DCs) are specialized antigen presenting cells that play a pivotal role in bridging innate and adaptive immune responses. Given the scarcity of peripheral blood myeloid dendritic cells (mDCs) investigators have used different model systems for studying DC biology. Monocyte-derived dendritic cells (moDCs) and KG-1 cells are routinely used as mDC models, but a thorough co ...
DOI:: 10.1186/gb-2007-8-3-r30
PubMed:: 17331236
PubMed Central:: PMC1868942
: https://doi.org/10.1186/gb-2007-8-3-r30

33. Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells

Author:: Kevin A. Goncalves; Lev Silberstein; Shuping Li; Nicolas Severe; Miaofen G. Hu; Hailing Yang; David T. Scadden; Guo-fu Hu
Source:: Cell 2016 v.166 pp. 894-906
ISSN:: 0092-8674
Subject:: functional properties; hematopoiesis; humans; irradiation; mice; protein synthesis; ribonucleases; ribosomal RNA; stem cells; tissues
Abstract:: ... Regulation of stem and progenitor cell populations is critical in the development, maintenance, and regeneration of tissues. Here, we define a novel mechanism by which a niche-secreted RNase, angiogenin (ANG), distinctively alters the functional characteristics of primitive hematopoietic stem/progenitor cells (HSPCs) compared with lineage-committed myeloid-restricted progenitor (MyePro) cells. Spe ...
DOI:: 10.1016/j.cell.2016.06.042
PubMed:: 27518564
PubMed Central:: PMC4988404
: https://doi.org/10.1016/j.cell.2016.06.042

34. Antagonistic effect of chitinolytic Pseudomonas and Bacillus on growth of fungal hyphae and spores of aflatoxigenic Aspergillus flavus

Author:: Pervin Basaran Akocak; John J. Churey; Randy W. Worobo
Source:: Food bioscience 2015 v.10 pp. 48-58
ISSN:: 2212-4292
Subject:: Aspergillus flavus; Bacillus cereus; Bacillus thuringiensis; N-acetylglucosamine; Pseudomonas fluorescens; aflatoxins; biological control; chitinase; functional properties; fungal spores; fungi; hazelnuts; humans; hyphae; mycelium; polymers; postharvest losses; scanning electron microscopy; spore germination; toxicity
Abstract:: ... Use of biological control methods has become a promising strategy to counteract deleterious fungal contaminations and substantial post harvest losses. One of the major biological control methods is found in the use of fungal cell wall-degrading enzymes such as chitinases, which hydrolyze the homopolymer of β-1,4-1inked N-acetylglucosamine residues exposed on the fungal cell surface. In this study, ...
DOI:: 10.1016/j.fbio.2015.01.005
: https://doi.org/10.1016/j.fbio.2015.01.005

35. Antioxidant and anticancer effects of functional peptides from ovotransferrin hydrolysates

Author:: Jae Hoon Lee; Sun Hee Moon; Hyun Suk Kim; Eunju Park; Dong Uk Ahn; Hyun‐Dong Paik
Source:: Journal of the science of food and agriculture 2017 v.97 no.14 pp. 4857-4864
ISSN:: 0022-5142
Subject:: 2,2-diphenyl-1-picrylhydrazyl; antineoplastic activity; antioxidant activity; antiviral properties; cytotoxicity; egg albumen; enzymatic hydrolysis; enzymes; food industry; free radical scavengers; functional properties; humans; hydrolysates; ingredients; inhibitory concentration 50; neoplasms; nitric oxide; peptides
Abstract:: ... BACKGROUND: Egg white is a good source for making functional peptides that can be used in the food industry. Ovotransferrin (OTF) is one of the major egg white proteins, with many functional properties, including antioxidant, antimicrobial and antiviral activities. However, enzymatic hydrolysis of ovotransferrin is known to further improve the functional activities of OTF. The aim of this study wa ...
DOI:: 10.1002/jsfa.8356
: https://doi.org/10.1002/jsfa.8356

36. Antioxidant, angiotensin-converting enzyme inhibitory activity and other functional properties of egg white proteins and their derived peptides – A review

Author:: E.D.N.S. Abeyrathne; X. Huang; D.U. Ahn
Source:: Poultry science 2018 v.97 no.4 pp. 1462-1468
ISSN:: 0032-5791
Subject:: antimicrobial properties; antioxidants; avidin; chemical treatment; egg albumen; enzymatic hydrolysis; enzyme inhibition; food processing; functional properties; heat treatment; humans; lysozyme; molecular weight; ovalbumin; ovomucin; pH; peptides; peptidyl-dipeptidase A
Abstract:: ... Egg white contains many functionally important proteins: ovalbumin (54%), ovotransferrin (12%), ovomucoid (11%), ovoglobulin (G2 and G3, 8%), ovomucin (3.5%), and lysozyme (3.5%) are major proteins, while ovoinhibitors, ovomacroglobulin, ovoglycoprotein, ovoflavoprotein, thiamine-binding proteins, and avidin are minor proteins present in egg white. These proteins, as well as the peptides derived f ...
DOI:: 10.3382/ps/pex399
: https://doi.org/10.3382/ps/pex399

37. Application and bioactive properties of proteins and peptides derived from hen eggs: opportunities and challenges

Author:: Zhipeng Yu; Yongguang Yin; Wenzhu Zhao; Feng Chen; Jingbo Liu
Source:: Journal of the science of food and agriculture 2014 v.94 no.14 pp. 2839-2845
ISSN:: 0022-5142
Subject:: absorption; antioxidants; bioactive properties; cardiovascular system; dietary protein; eggs; food industry; functional properties; gastrointestinal system; hens; humans; immune system; nervous system; peptides; proteins
Abstract:: ... Several proteins and peptides that are released in vitro and/or in vivo from hen eggs are biologically active and have a variety of functional properties in humans beyond normal nutrition, for which extensive studies have been performed. This review focuses on their biological activities, including antihypertensive, antioxidant, antimicrobial, antiadhesive, immunomodulatory and antithrombotic acti ...
DOI:: 10.1002/jsfa.6670
PubMed:: 24652758
: https://doi.org/10.1002/jsfa.6670

38. Application of diagnosticum based on functionalized carbon nanoparticles for monitoring of immunoglobulins affinity purification

Author:: P. V. Khramtsov; M. S. Bochkova; M. B. Rayev
Source:: Applied biochemistry and microbiology 2014 v.50 no.6 pp. 683-688
ISSN:: 0003-6838
Subject:: G-proteins; Streptococcus; blood serum; carbon; functional properties; humans; immunoglobulin G; monitoring; nanoparticles; polyclonal antibodies; rabbits; shelf life
Abstract:: ... A diagnostic reagent based on carbon nanoparticles covalently functionalized with streptococcus G protein was applied to construct a system for monitoring and optimization of the technology of affinity purification of rabbit polyclonal antibodies to alpha-fetoprotein. The developed system allows a short-time (45 min) semiquantitative assessment of the immunoglobulins (IgG) of most higher animals a ...
DOI:: 10.1134/S0003683814060064
: https://doi.org/10.1134/S0003683814060064

39. Artificial structures alter kelp functioning across an urbanised estuary

Author:: M. Mayer-Pinto; K.A. Dafforn; A.B. Bugnot; T.M. Glasby; E.L. Johnston
Source:: Marine environmental research 2018 v.139 pp. 136-143
ISSN:: 0141-1136
Subject:: Ecklonia radiata; anthropogenic activities; biomechanics; detritus; ecological footprint; environmental impact; estuaries; functional properties; habitats; humans; infrastructure; macroalgae; marine environment; photosynthesis; prediction; reefs; secondary productivity; sublethal effects; urbanization
Abstract:: ... Assessments of human impacts on natural habitats often focus on the abundance of component species, yet physiological and/or sub-lethal effects of stressors on functional attributes may be equally important to consider. Here we evaluated how artificial structures, an integral part of urbanisation in the marine environment, affects key functional properties of the habitat-forming kelp Ecklonia radi ...
DOI:: 10.1016/j.marenvres.2018.05.004
: https://doi.org/10.1016/j.marenvres.2018.05.004

40. Association of human tumor necrosis factor‐related apoptosis inducing ligand with membrane upon acidification

Author:: Gyu Hyun Nam; Kwan Yong Choi
Source:: European journal of biochemistry 2002 v.269 no.21 pp. 5280-5287
ISSN:: 0014-2956
Subject:: acidification; apoptosis; crystal structure; denaturation; fluorescence; functional properties; humans; hydrophobicity; lymphotoxin; necrosis; pH; phase transition; proteins; solvents; tryptophan; tumor necrosis factor-alpha; wavelengths
Abstract:: ... Tumor necrosis factor (TNF)‐related apoptosis inducing ligand (TRAIL) has been known to induce tumor‐specific apoptosis and to share the structural and functional characteristics with the proteins of TNF family. Recently, the crystal structure of human TRAIL showed that TRAIL is a homotrimeric protein whose subunits contain mainly β‐sheets. We characterized the structural changes of recombinant hu ...
DOI:: 10.1046/j.1432-1033.2002.03242.x
: https://doi.org/10.1046/j.1432-1033.2002.03242.x

41. Barley yellow dwarf viruses (BYDVs) preserved in herbarium specimens illuminate historical disease ecology of invasive and native grasses

Author:: MALMSTROM, CAROLYN M.; SHU, RUIJIE; LINTON, ERIC W.; NEWTON, LINSEY A.; COOK, MERIDITH A.
Source:: Journal of ecology 2007 v.95 no.6 pp. 1153-1166
ISSN:: 0022-0477
Subject:: Luteoviridae; RNA; barley; ecological invasion; ecosystems; functional properties; grasses; grasslands; herbaria; home range; horticulture; humans; indigenous species; invasive species; nucleotide sequences; pathogens; phylogeny; Australia; California
Abstract:: ... 1. In plant invasion ecology, viruses and other pathogens are often considered in terms of the enemy release hypothesis, which predicts that plants become invasive in new ranges if they escape pathogens from their home range. However, pathogens may sometimes facilitate host spread rather than hinder it. 2. Previously, we hypothesized that apparent competition mediated by barley and cereal yellow d ...
DOI:: 10.1111/j.1365-2745.2007.01307.x
: https://doi.org/10.1111/j.1365-2745.2007.01307.x

42. Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration

Author:: Sundaramoorthy Srinivasan; Arnau Cordomí; Eva Ramon; Pere Garriga
Source:: Cellular and molecular life sciences 2016 v.73 no.6 pp. 1253-1263
ISSN:: 1420-682X
Subject:: color vision; cones (retina); dark adaptation; functional properties; humans; molecular models; opsin; phototransduction; receptors; schiff bases; site-directed mutagenesis; spectroscopy
Abstract:: ... Human red and green visual pigments are seven transmembrane receptors of cone photoreceptor cells of the retina that mediate color vision. These pigments share a very high degree of homology and have been assumed to feature analogous structural and functional properties. We report on a different regeneration mechanism among red and green cone opsins with retinal analogs using UV–Vis/fluorescence s ...
DOI:: 10.1007/s00018-015-2043-7
: https://doi.org/10.1007/s00018-015-2043-7

43. Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile

Author:: Inés Jabeur; Flávia Tobaldini; Natália Martins; Lillian Barros; Ivone Martins; Ricardo C. Calhelha; Mariana Henriques; Sónia Silva; Lotfi Achour; Celestino Santos-Buelga; Isabel C.F.R. Ferreira
Source:: Food research international 2016 v.89 pp. 422-431
ISSN:: 0963-9969
Subject:: Hypericum androsaemum; active ingredients; anti-inflammatory activity; biofilm; chlorogenic acid; dose response; free radical scavengers; functional properties; growth retardation; hepatocytes; humans; lipid peroxidation; neoplasm cells; nitric oxide; phenolic compounds; swine; toxicity
Abstract:: ... Hypericum androsaemum L. ethanol:water extract acted as a lipid peroxidation inhibitor and free radical scavenger. A marked inhibition of the growth of breast, lung, cervical and hepatocellular human carcinoma cell lines was also observed, whereas no toxicity was shown against non-tumor porcine liver cells (>400μg/mL). The extract was also effective in inhibiting nitric oxide production, as an ind ...
DOI:: 10.1016/j.foodres.2016.08.040
: https://doi.org/10.1016/j.foodres.2016.08.040

44. Bioactivity of soy-based fermented foods: A review

Author:: Zhen-Hui Cao; Julia M. Green-Johnson; Nicole D. Buckley; Qiu-Ye Lin
Source:: Biotechnology advances 2019 v.37 no.1 pp. 223-238
ISSN:: 0734-9750
Subject:: animal models; bioactive compounds; consumer demand; diet; fermentation; flavor; functional properties; guidelines; humans; lifestyle; medical history; metabolites; microbial communities; microbiome; microorganisms; natto; nutritive value; soy sauce; soymilk; tempeh; toxicity; Asia
Abstract:: ... For centuries, fermented soy foods have been dietary staples in Asia and, now, in response to consumer demand, they are available throughout the world. Fermentation bestows unique flavors, boosts nutritional values and increases or adds new functional properties. In this review, we describe the functional properties and underlying action mechanisms of soy-based fermented foods such as Natto, ferme ...
DOI:: 10.1016/j.biotechadv.2018.12.001
: https://doi.org/10.1016/j.biotechadv.2018.12.001

45. Bioinspired multilayer membranes as potential adhesive patches for skin wound healing

Author:: Maria P. Sousa; Ana I. Neto; Tiago R. Correia; Sónia P. Miguel; Michiya Matsusaki; Ilídio J. Correia; João F. Mano
Source:: Biomaterials science 2018 v.6 no.7 pp. 1962-1975
ISSN:: 2047-4849
Subject:: DNA; alginates; biochemical pathways; cell adhesion; chitosan; dopamine; fibroblasts; fluorescent antibody technique; functional properties; humans; hyaluronic acid; inflammation; moieties; rats; scanning electron microscopy; strength (mechanics); tissue repair; ultraviolet-visible spectroscopy; viability; water uptake
Abstract:: ... Bioinspired and adhesive multilayer membranes are produced using the layer-by-layer (LbL) assembly of chitosan (CHT), alginate (ALG) and hyaluronic acid modified with dopamine (HA-DN). Freestanding multilayer membranes without DN are also produced as a control. The success of the synthesis of HA-DN was confirmed using UV-visible spectroscopy. Scanning electron microscopy images indicate that the s ...
DOI:: 10.1039/c8bm00319j
PubMed:: 29850674
PubMed Central:: PMC6420149
: https://doi.org/10.1039/c8bm00319j

46. Biomechanical and functional properties of trophoblast cells exposed to Group B Streptococcus in vitro and the beneficial effects of uvaol treatment

Author:: R.M. Botelho; L.P.G. Tenorio; A.L.M. Silva; E.L.L. Tanabe; K.S.N. Pires; C.M. Gonçalves; J.C. Santos; A.L.X. Marques; M.J. Allard; J.D. Bergeron; G. Sebire; E.C.O. Silva; S.T. Souza; E.J.S. Fonseca; A.U. Borbely; K.S.C. Borbely
Source:: Biochimica et biophysica acta 2019 v.1863 no.9 pp. 1417-1428
ISSN:: 0304-4165
Subject:: Streptococcus agalactiae; atomic force microscopy; bacteria; biomechanics; cell death; cell viability; cytoskeleton; death; diet; fluorescent antibody technique; functional properties; humans; inflammation; interferon-gamma; interleukin-1beta; interleukin-2; interleukin-4; nitrites; olive oil; pregnancy; pregnant women; secretion; triterpenoids; trophoblast
Abstract:: ... Group B streptococcus (GBS) is the main bacteria that infects pregnant women and can cause abortion and chorioamnionitis. The impact of GBS effects on human trophoblast cells remains largely elusive, and actions toward anti-inflammatory strategies in pregnancy are needed. A potent anti-inflammatory molecule, uvaol is a triterpene from olive oil and its functions in trophoblasts are unknown. We aim ...
DOI:: 10.1016/j.bbagen.2019.06.012
: https://doi.org/10.1016/j.bbagen.2019.06.012

47. Biomimetic LBL structured nanofibrous matrices assembled by chitosan/collagen for promoting wound healing

Author:: Rong Huang; Wangzhou Li; Xiaoxing Lv; Zhanjun Lei; Yongqian Bian; Hongbing Deng; Hongjun Wang; Jinqing Li; Xueyong Li
Source:: Biomaterials 2015 v.53 pp. 58-75
ISSN:: 0142-9612
Subject:: CD29 antigen; Western blotting; acetates; biocompatibility; biomimetics; cell movement; chitosan; collagen; fibroblasts; functional properties; humans; immunohistochemistry; nanofibers; non-specific protein-tyrosine kinase; phosphorylation; scanning electron microscopy; secretion; signal transduction; tubulin
Abstract:: ... This paper reports the fabrication of biomimetic nanofibrous matrices via co-electrospinning of polycaprolactone (PCL)/cellulose acetate (CA) and layer-by-layer self-assembly (LBL) of positively charged chitosan (CS) and negatively charged Type Ⅰ collagen on the nanofibrous matrix. FE-SEM images indicate that the average fiber diameter increased from 392 to 541 nm when the coating bilayers varied ...
DOI:: 10.1016/j.biomaterials.2015.02.076
: https://doi.org/10.1016/j.biomaterials.2015.02.076

48. Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation

Author:: Roberto Portillo-Lara; Andrew R. Spencer; Brian W. Walker; Ehsan Shirzaei Sani; Nasim Annabi
Source:: Biomaterials 2019 v.198 pp. 78-94
ISSN:: 0142-9612
Subject:: biocompatible materials; biofabrication; biomimetics; cardiovascular diseases; cell engineering; diagnostic techniques; drugs; functional properties; genetic engineering; health services; humans; industry; microfluidic technology; mortality; myocardium; organ-on-a-chip; patients; screening; stem cells; therapeutics; tissue engineering
Abstract:: ... Bioengineered tissues have become increasingly more sophisticated owing to recent advancements in the fields of biomaterials, microfabrication, microfluidics, genetic engineering, and stem cell and developmental biology. In the coming years, the ability to engineer artificial constructs that accurately mimic the compositional, architectural, and functional properties of human tissues, will profoun ...
DOI:: 10.1016/j.biomaterials.2018.08.010
: https://doi.org/10.1016/j.biomaterials.2018.08.010

49. Biopolymer-based coacervates: Structures, functionality and applications in food products

Author:: Thomas Moschakis; Costas G. Biliaderis
Source:: Current opinion in colloid & interface science 2017 v.28 pp. 96-109
ISSN:: 1359-0294
Subject:: bioactive compounds; biopolymers; digestion; foods; functional properties; gastrointestinal system; humans; ingredients; manufacturing; polysaccharides; proteins
Abstract:: ... Complex coacervates are self-assembly structures with many potential functional properties. Coacervates are mainly fabricated from proteins and polysaccharides and therefore they can be designed to function over a wide range of conditions in food products by withstanding adverse environmental stresses during manufacturing and storage and even upon passage through the human digestive track. They ca ...
DOI:: 10.1016/j.cocis.2017.03.006
: https://doi.org/10.1016/j.cocis.2017.03.006

50. Bioprocessing of human mesenchymal stem/stromal cells for therapeutic use: Current technologies and challenges

Author:: Aletta C. Schnitzler; Anjali Verma; Daniel E. Kehoe; Donghui Jing; Julie R. Murrell; Kara A. Der; Manjula Aysola; Peter J. Rapiejko; Sandhya Punreddy; Martha S. Rook
Source:: Biochemical engineering journal 2016 v.108 pp. 3-13
ISSN:: 1369-703X
Subject:: bioprocessing; cell culture; functional properties; humans; manufacturing; medicine; phenotype; stem cells; stromal cells; therapeutics; viability
Abstract:: ... The long-term outlook for regenerative medicine predicts an increased need for scalable cell expansion technologies that utilize non-animal derived materials and are compatible with the limited number of downstream processing steps required for cell-based therapies. As more stem cell therapeutics progress through clinical testing, current in vitro culture methods using planar vessels are proving c ...
DOI:: 10.1016/j.bej.2015.08.014
: https://doi.org/10.1016/j.bej.2015.08.014

51. Biosynthesis of dextran by Weissella confusa and its In vitro functional characteristics

Author:: Irina Rosca; Anca Roxana Petrovici; Dragos Peptanariu; Alina Nicolescu; Gianina Dodi; Mihaela Avadanei; Iuliu Cristian Ivanov; Andra Cristina Bostanaru; Mihai Mares; Diana Ciolacu
Source:: International journal of biological macromolecules 2018 v.107 pp. 1765-1772
ISSN:: 0141-8130
Subject:: Candida albicans; Fourier transform infrared spectroscopy; UHT milk; Weissella confusa; antibacterial properties; biofilm; biosynthesis; culture media; cytotoxicity; dextran; drugs; exopolysaccharides; fermentation; fibroblasts; freeze drying; functional properties; humans; hydrophilicity; lactic acid bacteria; nuclear magnetic resonance spectroscopy; nucleotide sequences; pharmaceutical industry; polymers; ribosomal DNA; sucrose; thermal analysis
Abstract:: ... The aim of this study was to monitor the influence of the fermentation conditions on the exopolysaccharides (EPS) biosynthesis. For this, different culture media compositions were tested on an isolated lactic acid bacteria (LAB) strain, identified by 16S rDNA sequence as being Weissella confusa. It was proved that this bacterial strain culture in MRS medium supplemented with 80g/L sucrose and diss ...
DOI:: 10.1016/j.ijbiomac.2017.10.048
: https://doi.org/10.1016/j.ijbiomac.2017.10.048

52. Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency

Author:: Stylianos Bournazos; Anna Gazumyan; Michael S. Seaman; Michel C. Nussenzweig; Jeffrey V. Ravetch
Source:: Cell 2016 v.165 pp. 1609-1620
ISSN:: 0092-8674
Subject:: HIV infections; Human immunodeficiency virus 1; animal models; epitopes; functional properties; glycoproteins; humans; immunoglobulin G; mice; mutants; neutralization; neutralizing antibodies; synergism; viremia
Abstract:: ... Broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) suppress viremia in animal models of HIV-1 and humans. To achieve potent activity without the emergence of viral escape mutants, co-administration of different bNAbs is necessary to target distinct epitopes essential for viral fitness. Here, we report the development of bispecific anti-Env neutralizing antibodies ...
DOI:: 10.1016/j.cell.2016.04.050
PubMed:: 27315478
PubMed Central:: PMC4970321
: https://doi.org/10.1016/j.cell.2016.04.050

53. Black Pepper and Health Claims: A Comprehensive Treatise

Author:: Masood Sadiq Butt; Imran Pasha; Muhammad Tauseef Sultan; Muhammad Atif Randhawa; Farhan Saeed; Waqas Ahmed
Source:: Critical reviews in food science and nutrition 2013 v.53 no.9 pp. 875-886
ISSN:: 1549-7852
Subject:: Piper nigrum; absorption; active ingredients; alkaloids; antidepressants; antioxidants; bioactive properties; black pepper; brain; cell culture; chemoprevention; cognition; cohort studies; functional foods; gastrointestinal system; health claims; healthy diet; humans; models; nutrients; oils; oleoresins; plant biochemistry; randomized clinical trials; trade
Abstract:: ... For millennia, spices have been an integral part of human diets and commerce. Recently, the widespread recognition of diet-health linkages bolsters their dietary importance. The bioactive components present in them are of considerable significance owing to their therapeutic potential against various ailments. They provide physiological benefits or prevent chronic ailment in addition to the fundame ...
DOI:: 10.1080/10408398.2011.571799
PubMed:: 23768180
: https://doi.org/10.1080/10408398.2011.571799

54. Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology

Author:: Luana Alves Dummer; Fábio Pereira Leivas Leite; Sylvia van Drunen Littel-van den Hurk
Source:: Veterinary research 2014 v.45 no.1 pp. 111
ISSN:: 1297-9716
Subject:: neutralization; Bovine alphaherpesvirus 1; virion; antigens; humans; DNA; cell-mediated immunity; cattle; immune system; vaccine development; viruses; neutralizing antibodies; functional properties; pathogenesis; receptors; glycoproteins; pathogens
Abstract:: ... The viral envelope glycoprotein D from bovine herpesviruses 1 and 5 (BoHV-1 and -5), two important pathogens of cattle, is a major component of the virion and plays a critical role in the pathogenesis of herpesviruses. Glycoprotein D is essential for virus penetration into permissive cells and thus is a major target for virus neutralizing antibodies during infection. In view of its role in the ind ...
DOI:: 10.1186/s13567-014-0111-x
PubMed:: 25359626
PubMed Central:: PMC4252008
: https://doi.org/10.1186/s13567-014-0111-x

55. C-termini are essential and distinct for nucleic acid binding of human NABP1 and NABP2

Author:: Venkatasubramanian Vidhyasagar; Yujiong He; Manhong Guo; Hao Ding; Tanu Talwar; Vi Nguyen; Jessica Nwosu; George Katselis; Yuliang Wu
Source:: Biochimica et biophysica acta 2016 v.1860 no.2 pp. 371-383
ISSN:: 0304-4165
Subject:: DNA-binding proteins; RNA; centrifugation; circular dichroism spectroscopy; functional properties; gel chromatography; humans; mass spectrometry; oligomerization; single-stranded DNA; sucrose
Abstract:: ... Human Nucleic Acid Binding Protein 1 and 2 (hNABP1 and 2; also known as hSSB2 and 1, respectively) are two newly identified single-stranded (ss) DNA binding proteins (SSB). Both NABP1 and NABP2 have a conserved oligonucleotide/oligosaccharide-binding (OB)-fold domain and a divergent carboxy-terminal domain, the functional importance of which is unknown.Recombinant hNABP1/2 proteins were purified u ...
DOI:: 10.1016/j.bbagen.2015.11.003
: https://doi.org/10.1016/j.bbagen.2015.11.003

56. CD11c⁺ Cells are Significantly Decreased in the Duodenum, Ileum and Colon of Dogs with Inflammatory Bowel Disease

Author:: A. Kathrani; S. Schmitz; S.L. Priestnall; K.C. Smith; D. Werling; O.A. Garden; K. Allenspach
Source:: Journal of comparative pathology 2011 v.145 no.4 pp. 359-366
ISSN:: 0021-9975
Subject:: Beagle; biopsy; colon; dendritic cells; dogs; duodenum; fluorescence microscopy; functional properties; guidelines; humans; ileum; inflammation; inflammatory bowel disease; mice; monoclonal antibodies
Abstract:: ... CD11c serves as a marker for human and murine dendritic cells (DCs) and cells expressing this marker have been shown to have similar morphological and functional characteristics in the canine immune system. The aim of this study was to quantify CD11c⁺ cells in the duodenum, ileum and colon of healthy dogs and dogs with inflammatory bowel disease (IBD). Endoscopic biopsies from the duodenum (n=12 c ...
DOI:: 10.1016/j.jcpa.2011.03.010
PubMed:: 21592490
: https://doi.org/10.1016/j.jcpa.2011.03.010

57. CD27 expression discriminates porcine T helper cells with functionally distinct properties

Author:: Katharina Reutner; Judith Leitner; Andrea Müllebner; Andrea Ladinig; Sabine E Essler; J Catharina Duvigneau; Mathias Ritzmann; Peter Steinberger; Armin Saalmüller; Wilhelm Gerner
Source:: Veterinary research 2013 v.44 no.1 pp. 224
ISSN:: 1297-9716
Subject:: T-lymphocytes; functional properties; humans; liver; lymph nodes; messenger RNA; monoclonal antibodies; phenotype; spleen; swine
Abstract:: ... Differentiation of porcine T helper cells is still poorly investigated, partly due to a lack of monoclonal antibodies (mAbs) specific for molecules involved in this process. Recently, we identified a mAb specific for porcine CD27 and showed that CD27 is expressed by all naïve CD8α⁻ T helper cells but divides CD8α⁺ T helper cells into a CD27⁺ and a CD27⁻ subset. In the present study, detailed pheno ...
DOI:: 10.1186/1297-9716-44-18
PubMed:: 23497134
PubMed Central:: PMC3610194
: https://doi.org/10.1186/1297-9716-44-18

58. CLERC and centrosomal leucine-rich repeat proteins

Author:: Yoshinori Muto; Yukio Okano
Source:: Open life sciences 2010 v.5 no.1 pp. 1-10
ISSN:: 2391-5412
Subject:: Chlamydomonas; centrosomes; databases; functional properties; humans; mitosis; proteins; proteome
Abstract:: ... The centrosome functions as the microtubule-organizing center and plays a vital role in organizing spindle poles during mitosis. Recently, we identified a centrosomal protein called CLERC (Centrosomal leucine-rich repeat and coiled-coil containing protein) which is a human ortholog of Chlamydomonas Vfl1 protein. The bibliography as well as database searches provided evidence that the human proteom ...
DOI:: 10.2478/s11535-009-0061-x
: https://doi.org/10.2478/s11535-009-0061-x

59. Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes

Author:: Mads T. Søndergaard; Anders B. Sorensen; Louise L. Skov; Kasper Kjaer‐Sorensen; Mikael C. Bauer; Mette Nyegaard; Sara Linse; Claus Oxvig; Michael T. Overgaard
Source:: FEBS journal 2015 v.282 no.4 pp. 803-816
ISSN:: 1742-464X
Subject:: Danio rerio; abnormal development; animal models; calmodulin; cardiomyocytes; death; eukaryotic cells; exercise; functional properties; heart rate; humans; messenger RNA; mutation; phenotype; syncope; tachycardia
Abstract:: ... Calmodulin (CaM) is the central mediator of intracellular Ca²⁺signalling in cardiomyocytes, where it conveys the intricate Ca²⁺transients to the proteins controlling cardiac contraction. We recently linked two separate mutations in CaM (N53I and N97S) to dominantly inherited catecholaminergic polymorphic ventricular tachycardia (CPVT), an arrhythmic disorder in which exercise or acute emotion can ...
DOI:: 10.1111/febs.13184
: https://doi.org/10.1111/febs.13184

60. Camu-camu seed (Myrciaria dubia) – From side stream to an antioxidant, antihyperglycemic, antiproliferative, antimicrobial, antihemolytic, anti-inflammatory, and antihypertensive ingredient

Author:: Marina Fidelis; Mariana Araújo Vieira do Carmo; Thiago Mendanha da Cruz; Luciana Azevedo; Takao Myoda; Marianna Miranda Furtado; Mariza Boscacci Marques; Anderson S. Sant'Ana; Maria Inês Genovese; Won Young Oh; Mingchun Wen; Fereidoon Shahidi; Liang Zhang; Marcelo Franchin; Severino Matias de Alencar; Pedro Luiz Rosalen; Daniel Granato
Source:: Food chemistry 2020 v.310 pp. 125909
ISSN:: 0308-8146
Subject:: Myrciaria dubia; alpha-amylase; alpha-glucosidase; antihypertensive effect; antimicrobial properties; antioxidant activity; antioxidants; bioactive compounds; bioassays; cell culture; copper; cytotoxicity; enzyme inhibition; erythrocytes; functional properties; glycemic effect; hemolysis; humans; ingredients; low density lipoprotein; macrophages; neoplasm cells; neoplasms; oxidation; phenolic compounds; seeds; solvents; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Camu-camu (Myrciaria dubia) seeds are discarded without recovering the bioactive compounds. The main aim of the present work was to optimise the solvent mixture to extract higher total phenolic content and antioxidant capacity of camu-camu seeds. The optimised solvent system increased the extraction of phenolic compounds, in which vescalagin and castalagin were the main compounds. The optimised ex ...
DOI:: 10.1016/j.foodchem.2019.125909
: https://doi.org/10.1016/j.foodchem.2019.125909

61. Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia

Author:: A. Kalyanasundaram; N. Li; B.J. Hansen; J. Zhao; V.V. Fedorov
Source:: Journal of veterinary cardiology 2018 pp. -
ISSN:: 1760-2734
Subject:: cardiac arrest; cell communication; dogs; drugs; functional properties; heart; heart failure; heart rate; humans; ion channels; myocytes; receptors; tachycardia; tissues
Abstract:: ... The sinoatrial node (SAN) is the primary pacemaker in canine and human hearts. The SAN in both species has a unique three-dimensional heterogeneous structure characterized by small pacemaker myocytes enmeshed within fibrotic strands, which partially insulate the cells from aberrant atrial activation. The SAN pacemaker tissue expresses a unique signature of proteins and receptors that mediate SAN a ...
DOI:: 10.1016/j.jvc.2018.10.004
PubMed:: 30559056
PubMed Central:: PMC6436970
: https://doi.org/10.1016/j.jvc.2018.10.004

62. Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells

Author:: Roberto Gaetani; Peter A. Doevendans; Corina H.G. Metz; Jacqueline Alblas; Elisa Messina; Alessandro Giacomello; Joost P.G. Sluijter
Source:: Biomaterials 2012 v.33 no.6 pp. 1782-1790
ISSN:: 0142-9612
Subject:: biocompatible materials; bioprinting; cardiomyocytes; cell viability; functional properties; gene expression; humans; stem cells; therapeutics; tissue engineering; transcription factors
Abstract:: ... Tissue engineering is emerging as a potential therapeutic approach to overcome limitations of cell therapy, like cell retention and survival, as well as to mechanically support the ventricular wall and thereby prevent dilation. Tissue printing technology (TP) offers the possibility to deliver, in a defined and organized manner, scaffolding materials and living cells. The aim of our study was to ev ...
DOI:: 10.1016/j.biomaterials.2011.11.003
: https://doi.org/10.1016/j.biomaterials.2011.11.003

63. Cardioprotective properties of grape seed proanthocyanidins: An update

Author:: M. Antónia Nunes; Filipa Pimentel; Anabela S.G. Costa; Rita C. Alves; Maria Beatriz P.P. Oliveira
Source:: Trends in food science & technology 2016 v.57 pp. 31-39
ISSN:: 0924-2244
Subject:: Vitis vinifera; agricultural industry; bark; blood lipids; blood pressure; byproducts; cardioprotective effect; cardiovascular diseases; endothelium; foods; fruits; functional properties; grape seeds; grapes; human health; humans; ingredients; nutritive value; nuts; proanthocyanidins; risk factors; seeds; synergism; value added
Abstract:: ... The nutritional properties of grapes (Vitis vinifera L.) and derived-grape products are known for a long time. To produce those food products, the agro-industry generates great amounts of by-products. The re-use of these undervalued materials is challenging because it represents an attractive opportunity to convert them into value-added sources of natural ingredients with potential human health be ...
DOI:: 10.1016/j.tifs.2016.08.017
: https://doi.org/10.1016/j.tifs.2016.08.017

64. Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage

Author:: Wei, Dongguang; Levic, Snezana; Nie, Liping; Gao, Wei-qiang; Petit, Christine; Jones, Edward G.; Yamoah, Ebenezer N.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.52 pp. 21000-21005
ISSN:: 0027-8424
Subject:: adults; brain; ears; epigenetics; epithelium; functional properties; ganglia; hearing; humans; neurons; rodents; stem cells; therapeutics
Abstract:: ... Auditory hair cell defect is a major cause of hearing impairment, often leading to spiral ganglia neuron (SGN) degeneration. The cell loss that follows is irreversible in mammals, because inner ear hair cells (HCs) have a limited capacity to regenerate. Here, we report that in the adult brain of both rodents and humans, the ependymal layer of the lateral ventricle contains cells with proliferative ...
DOI:: 10.1073/pnas.0808044105
PubMed:: 19064919
PubMed Central:: PMC2634930
: https://doi.org/10.1073/pnas.0808044105

65. Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds

Author:: Bocanegra, Aránzazu; Bastida, Sara; Benedi, Juana; Rodenas, Sofia; Sánchez-Muniz, Francisco J.
Source:: Journal of medicinal food 2009 v.12 no.2 pp. 236-258
ISSN:: 1096-620X
Subject:: nutrient content; algae; vitamins; blood pressure; health foods; energy content; edible seaweed; mineral content; dietary fiber; humans; phytochemicals; body weight; lipid metabolism; antioxidant activity; weight gain; nutrient availability; nutritive value; functional properties; polyunsaturated fatty acids; dietary minerals
DOI:: 10.1089/jmf.2008.0151
PubMed:: 19459725
: https://doi.org/10.1089/jmf.2008.0151

66. Characteristics of One Health surveillance systems: A systematic literature review

Author:: Marion Bordier; Theethawat Uea-Anuwong; Aurélie Binot; Pascal Hendrikx; Flavie L. Goutard
Source:: Preventive veterinary medicine 2020 v.181 pp. 104560
ISSN:: 0167-5877
Subject:: One Health initiative; cost effectiveness; databases; environmental health; functional properties; governance; guidelines; health hazards; humans; monitoring; screening; stakeholders; uncertainty
Abstract:: ... The concept of One Health (OH) promotes the decompartmentalisation of human, animal, and ecosystem health for the more efficient and sustainable governance of complex health issues. This means that traditional boundaries between disciplines and sectors must be transgressed and that all relevant stakeholders must be involved in the definition and management of health problems. International efforts ...
DOI:: 10.1016/j.prevetmed.2018.10.005
: https://doi.org/10.1016/j.prevetmed.2018.10.005

67. Characterization of Human Fungiform Papillae Cells in Culture

Author:: Mehmet Hakan Ozdener; Joseph G. Brand; Andrew I. Spielman; Fritz W. Lischka; John H. Teeter; Paul A.S. Breslin; Nancy E. Rawson
Source:: Chemical senses 2011 v.36 no.7 pp. 601-612
ISSN:: 0379-864X
Subject:: biopsy; calcium; functional properties; humans; models; signal transduction; taste; viability
Abstract:: ... The ability to maintain human fungiform papillae cells in culture for multiple cell cycles would be of considerable utility for characterizing the molecular, regenerative, and functional properties of these unique sensory cells. Here we describe a method for enzymatically isolating human cells from fungiform papillae obtained by biopsy and maintaining them in culture for more than 7 passages (7 mo ...
DOI:: 10.1093/chemse/bjr012
PubMed:: 21471186
PubMed Central:: PMC3155391
: https://doi.org/10.1093/chemse/bjr012

68. Characterization of casein and alpha lactalbumin of African elephant (Loxodonta africana) milk

Author:: M. Madende; G. Osthoff; H-G. Patterton; H.E. Patterton; P. Martin; D.J. Opperman
Source:: Journal of dairy science 2015 v.98 no.12 pp. 8308-8318
ISSN:: 0022-0302
Subject:: Loxodonta africana; alcohols; alpha-casein; amino acid sequences; beta-casein; cattle; crystal structure; dairy animals; databases; functional properties; humans; hydrophilicity; kappa-casein; lactalbumin; lactose; mammary glands; micelles; milk; models; nucleotide sequences; sequence alignment; whey protein
Abstract:: ... The current research reports partial characterization of the caseins and α-lactalbumin (α-LA) of the African elephant with proposed unique structure-function properties. Extensive research has been carried out to understand the structure of the casein micelles. Crystallographic structure elucidation of caseins and casein micelles is not possible. Consequently, several models have been developed in ...
DOI:: 10.3168/jds.2014-9195
: https://doi.org/10.3168/jds.2014-9195

69. Characterization of dextran-grafted hydrophobic charge-induction resins: Structural properties, protein adsorption and transport

Author:: Tao Liu; James M. Angelo; Dong-Qiang Lin; Abraham M. Lenhoff; Shan-Jing Yao
Source:: Journal of chromatography 2017 pp. -
ISSN:: 0021-9673
Subject:: adsorption; agarose; bovine serum albumin; confocal laser scanning microscopy; dextran; functional properties; gel chromatography; humans; hydrophobicity; immunoglobulin G; ligands; resins; salt concentration; salt tolerance; sorption isotherms
Abstract:: ... The structural and functional properties of a series of dextran-grafted and non-grafted hydrophobic charge-induction chromatographic (HCIC) agarose resins were characterized by macroscopic and microscopic techniques. The effects of dextran grafting and mobile phase conditions on the pore dimensions of the resins were investigated with inverse size exclusion chromatography (ISEC). A significantly l ...
DOI:: 10.1016/j.chroma.2017.07.090
: https://doi.org/10.1016/j.chroma.2017.07.090

70. Characterization of functional properties of Enterococcus faecium strains isolated from human gut

Author:: Hümeyra İspirli; Fatmanur Demirbaş; Enes Dertli
Source:: Canadian journal of microbiology 2015 v.61 no.11 pp. 861-870
ISSN:: 1480-3275
Subject:: Enterococcus faecium; acid tolerance; adhesion; anti-infective properties; antibiotic resistance; bacteriocins; bile salts; digestive system; enzymatic treatment; feces; functional properties; genes; heat treatment; hemolysis; hexadecane; humans; in vitro digestion; metabolism; pH; pathogens; polymerase chain reaction; probiotics; proteolysis; screening; vancomycin; virulence
Abstract:: ... The aim of this work was to characterize the functional properties of Enterococcus faecium strains identified after isolation from human faeces. Of these isolates, strain R13 showed the best resistance to low pH, bile salts, and survival in the simulated in vitro digestion assay, and demonstrated an important level of adhesion to hexadecane as a potential probiotic candidate. Analysis of the antib ...
DOI:: 10.1139/cjm-2015-0446
: https://doi.org/10.1139/cjm-2015-0446

71. Characterization of human leukocyte-HUVEC adhesion: Effect of cell preparation methods

Author:: Franca Marino; Laura Schembri; Emanuela Rasini; Monica Pinoli; Angela Scanzano; Alessandra Luini; Terenzio Congiu; Marco Cosentino
Source:: Journal of Immunological Methods 2017 v.443 pp. 55-63
ISSN:: 0022-1759
Subject:: adhesion; blood sampling; cell adhesion; coculture; endothelial cells; flow cytometry; functional properties; granulocytes; humans; in vitro studies; intercellular adhesion molecule-1; light microscopy; scanning electron microscopy; tumor necrosis factor-alpha
Abstract:: ... Sample manipulation to obtain isolated granulocytes represents a key, and often necessary, step in the in vitro studies. We investigated by the means of flow cytometry and microscopic techniques (both optical microscopy [OM] and scanning electron microscopy [SEM]), the granulocyte-endothelium adhesion and the role of sample manipulation.By means of a co-culture method, we have analysed the adhesio ...
DOI:: 10.1016/j.jim.2017.01.013
: https://doi.org/10.1016/j.jim.2017.01.013

72. Characterization of hyaluronic acid specific hyaluronate lyase (HylP) from Streptococcus pyogenes

Author:: Sudhir Kumar Singh; Soniya Malhotra; Md. Sohail Akhtar
Source:: Biochimie 2014 v.102 pp. 203-210
ISSN:: 0300-9084
Subject:: Escherichia coli; Streptococcus pyogenes; amino acids; bacteriophages; calcium; enzyme activity; functional properties; humans; hyaluronic acid; ions; mutation; toxigenic strains; virulence
Abstract:: ... Streptococcus pyogenes is associated with a wide variety of mucosal and invasive infections that claim human life. The conversion from non pathogenic to toxigenic strain of S. pyogenes are thought to be mediated by bacteriophage infection in several cases. The hyaluronic acid (HA) degrading enzyme Hyaluronate lyase (HL) is proposed to be one of the key bacteriophage-encoded virulence factors. In t ...
DOI:: 10.1016/j.biochi.2014.03.012
: https://doi.org/10.1016/j.biochi.2014.03.012

73. Characterization of the fundamental properties of the N-terminal truncation (Δ exon 1) variant of estrogen receptor α in the rat

Author:: Yujiro Hattori; Hirotaka Ishii; Akio Morita; Yasuo Sakuma; Hitoshi Ozawa
Source:: Gene 2015 v.571 pp. 117-125
ISSN:: 0378-1119
Subject:: messenger RNA; alternative splicing; transcriptional activation; estrogen receptors; humans; luciferase; reverse transcriptase polymerase chain reaction; transcription (genetics); mice; functional properties; rats; exons
Abstract:: ... The estrogen receptor α (ERα) directs transactivation of target genes, and splice variants have been shown to exhibit altered activation properties. We previously documented the complicated alternative promoter usage and splicing patterns of the rat ERα gene; however, the information was restricted to a few specific organs. Therefore, we re-examined the rat mRNA profiles of ERα, including the gene ...
DOI:: 10.1016/j.gene.2015.06.086
: https://doi.org/10.1016/j.gene.2015.06.086

74. Characterization of the neuraminidase of the H1N1/09 pandemic influenza virus

Author:: T. Gerlach; L. Kühling; J. Uhlendorff; V. Laukemper; T. Matrosovich; V. Czudai-Matwich; F. Schwalm; H.-D. Klenk; M. Matrosovich
Source:: Vaccine 2012 v.30 no.51 pp. 7348-7352
ISSN:: 0264-410X
Subject:: Orthomyxoviridae; birds; erythrocytes; functional properties; genes; humans; hydrolysis; mucins; neutralization; pandemic; sialidase; swine; vaccines; vertebrate viruses; viruses
Abstract:: ... In this study, we compared properties of the neuraminidase (NA) of the H1N1/2009 pandemic virus (H1N1pdm) and N1 NAs of other influenza viruses. The H1N1pdm NA was more active than NAs of seasonal H1N1 viruses, hydrolyzed Neu5Acα2-3Gal linkage as efficiently as did avian viruses and cleaved Neu5Acα2-6Gal linkage as efficiently as classical swine viruses. To assess the functional balance between he ...
DOI:: 10.1016/j.vaccine.2012.09.078
: https://doi.org/10.1016/j.vaccine.2012.09.078

75. Cheeses as food matrixes for probiotics: In vitro and in vivo tests

Author:: Fernanda R.L. Rolim; Oliveiro C. Freitas Neto; Maria Elieidy G. Oliveira; Celso J.B. Oliveira; Rita C.R.E. Queiroga
Source:: Trends in food science & technology 2020 v.100 pp. 138-154
ISSN:: 0924-2244
Subject:: buffering capacity; cheeses; clinical trials; food matrix; foods; functional properties; humans; in vitro studies; in vivo studies; intestinal mucosa; mechanism of action; nutrient availability; oxygen; pH; probiotics; sensory properties; shelf life; viability
Abstract:: ... Probiotics are microorganisms that promote beneficial health effects. To do this, they must survive passage through the gastrointestinal tract, adhere and colonize in the intestinal epithelium. Foods are vehicles that protect these strains during this passage, in particular cheese, which has advantages such as availability of nutrients, high pH, higher buffering capacity and low oxygen content. Th ...
DOI:: 10.1016/j.tifs.2020.04.008
: https://doi.org/10.1016/j.tifs.2020.04.008

76. Chemical profile, antiproliferative, antioxidant and enzyme inhibition activities of Ocimum basilicum L. and Pulicaria undulata (L.) C.A. Mey. grown in Sudan

Author:: Atif B.A. Mohammed; Sakina Yagi; Tzvetomira Tzanova; Hervé Schohn; Haider Abdelgadir; Azzurra Stefanucci; Adriano Mollica; Mohamad Fawzi Mahomoodally; Talal A. Adlan; Gökhan Zengin
Source:: South African journal of botany 2020 v.132 pp. 403-409
ISSN:: 0254-6299
Subject:: Ocimum basilicum; Pulicaria undulata; acarbose; acetylcholinesterase; adenocarcinoma; alpha-amylase; antioxidant activity; antioxidants; assays; breast neoplasms; cell lines; cell viability; chemical composition; cholinesterase; colon; computer simulation; cosmetics; enzyme activity; enzyme inhibition; essential oils; free radicals; functional properties; gas chromatography-mass spectrometry; humans; ions; linalool; methyl chavicol; oils; pharmaceutical industry; stems; Sudan
Abstract:: ... In the present study, essential oils extracted from the leafy stems of Ocimum basilicum (Family Lamiaceae) and Pulicaria undulata (Family Asteraceae) were investigated for their chemical profiles and biological activity including antioxidant, antiproliferative and enzyme inhibition activities. The chemical composition of essential oil was determined using Gas Chromatography-Mass Spectrometry. The ...
DOI:: 10.1016/j.sajb.2020.06.006
: https://doi.org/10.1016/j.sajb.2020.06.006

77. Chimeric proteins constructed from bacteriophage T7 gp4 and a putative primase–helicase from Arabidopsis thaliana

Author:: Jamie B. Towle-Weicksel; Yun Cao; Lisa J. Crislip; David L. Thurlow; Donald J. Crampton
Source:: Molecular biology reports 2014 v.41 no.12 pp. 7783-7795
ISSN:: 0301-4851
Subject:: Arabidopsis thaliana; DNA helicases; DNA-directed DNA polymerase; DNA-directed RNA polymerase; Escherichia coli; bacteriophages; chimerism; functional properties; humans; mitochondrial DNA; open reading frames; proteins; zinc
Abstract:: ... An open reading frame from Arabidopsis thaliana, which is highly homologous to the human mitochondrial DNA helicase TWINKLE, was previously cloned, expressed, and shown to have DNA primase and DNA helicase activity. The level of DNA primase activity of this Arabidopsis Twinkle homolog (ATH) was low, perhaps due to an incomplete zinc binding domain (ZBD). In this study, N-terminal truncations of AT ...
DOI:: 10.1007/s11033-014-3671-y
: https://doi.org/10.1007/s11033-014-3671-y

78. Cinnamomum cassia essential oil and its major constituent cinnamaldehyde induced cell cycle arrest and apoptosis in human oral squamous cell carcinoma HSC‐3 cells

Author:: Wen‐Lun Chang; Fu‐Chou Cheng; Shu‐Ping Wang; Su‐Tze Chou; Ying Shih
Source:: Environmental toxicology 2017 v.32 no.2 pp. 456-468
ISSN:: 1520-4081
Subject:: Cinnamomum aromaticum; DNA; DNA damage; antineoplastic activity; apoptosis; calcium; cell cycle checkpoints; cell viability; chromatin; cytochrome c; enzyme activity; essential oils; functional properties; glutathione; glutathione peroxidase; humans; membrane potential; mitochondria; mitochondrial membrane; reactive oxygen species; squamous cell carcinoma; thiobarbituric acid-reactive substances
Abstract:: ... Cinnamomum cassia essential oil (CC‐EO) has various functional properties, such as anti‐microbial, hypouricemic, anti‐tyrosinase and anti‐melanogenesis activities. The present study aimed to evaluate the anti‐cancer activities of CC‐EO and its major constituent, cinnamaldehyde, in human oral squamous cell carcinoma HSC‐3 cells. Determination of the cell viability, apoptotic characteristics, DNA da ...
DOI:: 10.1002/tox.22250
: https://doi.org/10.1002/tox.22250

79. Clitoria ternatea L. petal bioactive compounds display antioxidant, antihemolytic and antihypertensive effects, inhibit α-amylase and α-glucosidase activities and reduce human LDL cholesterol and DNA induced oxidation

Author:: Graziela Bragueto Escher; Mariza Boscacci Marques; Mariana Araújo Vieira do Carmo; Luciana Azevedo; Marianna Miranda Furtado; Anderson S. Sant'Ana; Marcia Cristina da Silva; Maria Inês Genovese; Mingchun Wen; Liang Zhang; Won Young Oh; Fereidoon Shahidi; Neiva Deliberali Rosso; Daniel Granato
Source:: Food research international 2020 v.128 pp. 108763
ISSN:: 0963-9969
Subject:: Clitoria ternatea; DNA; absorption; alpha-amylase; alpha-glucosidase; antihypertensive effect; antimicrobial properties; antioxidant activity; bioactive compounds; cell lines; cleavage (chemistry); corolla; cytotoxicity; enzyme activity; enzyme inhibition; erythrocytes; freeze drying; functional properties; hemolysis; humans; inhibitory concentration 50; lethal concentration 50; lipid peroxidation; low density lipoprotein cholesterol; oxidation; phenolic compounds; principal component analysis; protective effect; reactive oxygen species; temperature
Abstract:: ... The purpose of this study was to use a statistical approach to optimise the experimental conditions regarding the extraction of bioactive compounds, and to analyse the in vitro functional properties of crude lyophilized extracts (CLE) and partially purified (PPE) extracts of Clitoria ternatea petals. The results showed that the factors of temperature and time influenced the extraction of phenolic ...
DOI:: 10.1016/j.foodres.2019.108763
: https://doi.org/10.1016/j.foodres.2019.108763

80. Comparability studies of new 3rd generation recombinant human factor VIII GreenGene F after improvement of formulation and viral inactivation/removal process

Author:: Sang Hoon Paik; Yong Jae Kim; Sang Kyul Han; Ji-youn Kim; Hanna Park; Young In Park
Source:: Biologicals 2012 v.40 no.6 pp. 405-414
ISSN:: 1045-1056
Subject:: World Health Organization; clinical trials; factor VIII; functional properties; humans; intravenous injection; manufacturing; mice; nanofiltration; pathogens; peptides; risk; solvents; toxicity; viruses; South Korea
Abstract:: ... A new 3rd generation recombinant factor VIII (rFVIII), GreenGene F (WHO INN: beroctocog alfa), which is a highly homogenous B-domain deleted FVIII protein comprising of two peptides as heavy chain (A1 and A2 domain) and light chain (A3, C1, and C2 domain) at 80 and 90 kDa, was developed from its predecessor product GreenGene (2nd generation product previously approved by Korea FDA after clinical s ...
DOI:: 10.1016/j.biologicals.2012.09.004
: https://doi.org/10.1016/j.biologicals.2012.09.004

81. Comparative and bioinformatics analyses of pathogenic bacterial secretomes identified by mass spectrometry in Burkholderia species

Author:: Thao Thi Nguyen; Tae-Soo Chon; Jaehan Kim; Young-Su Seo; Muyoung Heo
Source:: journal of microbiology 2017 v.55 no.7 pp. 568-582
ISSN:: 1225-8873
Subject:: Burkholderia glumae; Markov chain; bioinformatics; blight; data collection; functional properties; hosts; humans; hydrophobicity; inflorescences; mass spectrometry; pathogenesis; plant pathogens; protein secretion; proteins; rice; seedlings
Abstract:: ... Secreted proteins (secretomes) play crucial roles during bacterial pathogenesis in both plant and human hosts. The identification and characterization of secretomes in the two plant pathogens Burkholderia glumae BGR1 and B. gladioli BSR3, which cause diseases in rice such as seedling blight, panicle blight, and grain rot, are important steps to not only understand the disease-causing mechanisms bu ...
DOI:: 10.1007/s12275-017-7085-0
: https://doi.org/10.1007/s12275-017-7085-0

82. Comparative functional characterization of canine IgG subclasses

Author:: Lisa M. Bergeron; Erin E. McCandless; Steve Dunham; Bill Dunkle; Yaqi Zhu; John Shelly; Sandra Lightle; Andrea Gonzales; Graeme Bainbridge
Source:: Veterinary immunology and immunopathology 2014 v.157 no.1-2 pp. 31-41
ISSN:: 0165-2427
Subject:: chimerism; complement; cytotoxicity; dogs; functional properties; humans; immune system; immunoglobulin G; monoclonal antibodies; receptors; veterinary medicine
Abstract:: ... To date, very little is known about the functional characteristics of the four published canine IgG subclasses. It is not clear how each subclass engages the immune system via complement-dependent cytotoxicity (CDC) or antibody-dependent cell-mediated cytotoxicity (ADCC), or how long each antibody may last in serum. Such information is critical for understanding canine immunology and for the disco ...
DOI:: 10.1016/j.vetimm.2013.10.018
: https://doi.org/10.1016/j.vetimm.2013.10.018

83. Comparative phylogenetic analysis of small GTP-binding genes of model legume plants and assessment of their roles in root nodules

Author:: Yuksel, Bayram; Memon, Abdul R.
Source:: Journal of experimental botany 2008 v.59 no.14 pp. 3831-3844
ISSN:: 0022-0957
Subject:: Arabidopsis; G-proteins; Lotus corniculatus var. japonicus; Medicago truncatula; RNA; cell division; functional properties; genes; genetic techniques and protocols; guanosinetriphosphatase; humans; legumes; mutants; nodulation; nucleotide sequences; phylogeny; root nodules; signal transduction; yeasts
Abstract:: ... Small GTP-binding genes play an essential regulatory role in a multitude of cellular processes such as vesicle-mediated intracellular trafficking, signal transduction, cytoskeletal organization, and cell division in plants and animals. Medicago truncatula and Lotus japonicus are important model plants for studying legume-specific biological processes such as nodulation. The publicly available onli ...
DOI:: 10.1093/jxb/ern223
PubMed:: 18849296
PubMed Central:: PMC2576638
: https://doi.org/10.1093/jxb/ern223

84. Comparative studies on osmosis based encapsulation of sodium diclofenac in porcine and outdated human erythrocyte ghosts

Author:: Katarina Bukara; Ivana Drvenica; Vesna Ilić; Ana Stančić; Danijela Mišić; Borislav Vasić; Radoš Gajić; Dušan Vučetić; Filip Kiekens; Branko Bugarski
Source:: Journal of biotechnology 2016 v.240 pp. 14-22
ISSN:: 0168-1656
Subject:: Fourier transform infrared spectroscopy; chemical reactions; diclofenac; drug delivery systems; drugs; encapsulation; erythrocytes; functional properties; hemolysis; humans; lipids; osmosis; potassium; slaughterhouses; surface roughness; swine
Abstract:: ... The objective of our study was to develop controlled drug delivery system based on erythrocyte ghosts for amphiphilic compound sodium diclofenac considering the differences between erythrocytes derived from two readily available materials – porcine slaughterhouse and outdated transfusion human blood. Starting erythrocytes, empty erythrocyte ghosts and diclofenac loaded ghosts were compared in term ...
DOI:: 10.1016/j.jbiotec.2016.10.017
: https://doi.org/10.1016/j.jbiotec.2016.10.017

85. Comparative studies on the heterogeneity of plasma-derived and recombinant human albumins in laboratory use

Author:: Takeshi Minami; Tomoyoshi Terada; Teppei Takahashi; Hajime Arikawa; Yukie Matsuyama; Kazuha Kizaki; Seiichi Era
Source:: International journal of biological macromolecules 2014 v.69 pp. 79-87
ISSN:: 0141-8130
Subject:: cell growth; denaturation; fatty acids; fractionation; functional properties; human serum albumin; humans; rice; thermal stability
Abstract:: ... We investigated the thiol-redox state, and the relationship between structural characteristics, such as thermal stability, and functional properties, such as cell growth activity, of commercial plasma-derived (pHSA) and recombinant human serum albumin (rHSA) products. In this study, 5 pHSA products (A1653, A9511, A1887, A8763, and A3782) and 2 rHSA products (A9731 and A9986) were obtained from Sig ...
DOI:: 10.1016/j.ijbiomac.2014.05.010
: https://doi.org/10.1016/j.ijbiomac.2014.05.010

86. Composition, antibacterial, antioxidant and antiproliferative activities of essential oils from three Origanum species growing wild in Lebanon and Greece

Author:: Mariangela Marrelli; Filomena Conforti; Carmen Formisano; Daniela Rigano; Nelly Apostolides Arnold; Francesco Menichini; Felice Senatore
Source:: Natural product research 2016 v.30 no.6 pp. 735-739
ISSN:: 1478-6427
Subject:: Escherichia coli; Gram-positive bacteria; Origanum dictamnus; antioxidant activity; antioxidants; carvacrol; essential oils; flavor; food quality; functional foods; functional properties; gamma-terpinene; gas chromatography-mass spectrometry; humans; linalool; oils; p-cymene; Greece; Lebanon
Abstract:: ... The essential oils from Origanum dictamnus , Origanum libanoticum and Origanum microphyllum were analysed by GC-MS, finding carvacrol, p-cymene, linalool, γ-terpinene and terpinen-4-ol as major components. The antioxidant activity by the DPPH and FRAP tests and the antiproliferative activity against two human cancer cell lines, LoVo and HepG2, were investigated, showing that the essential oil of O ...
DOI:: 10.1080/14786419.2015.1040993
: https://doi.org/10.1080/14786419.2015.1040993

87. Compositional and functional characterisation of poppy seed (Papaver somniferum L.) press cake meals

Author:: E. Yılmaz; D. Dündar Emir
Source:: Quality assurance and safety of crops & foods 2017 v.9 no.2 pp. 141-151
ISSN:: 1757-837X
Subject:: Papaver somniferum; calcium; cold; emulsifying; emulsifying properties; emulsions; enzymatic treatment; foaming; foaming capacity; foams; gelation; humans; magnesium; minerals; oilmeals; oils; phytic acid; potassium; quality control; roasting; seeds; sodium; viscosity; water holding capacity; zinc
Abstract:: ... In this study, three registered poppy seed varieties (Ofis 3, Ofis 4 and Ofis 8) were used. The compositional and functional properties of the defatted meals (cakes) obtained from previously treated (pre-roasting and enzyme treatment against control) and cold pressed poppy seeds were determined. Moisture (11.01-16.21%), protein (26.87-35.14%), oil (2.32-4.28%), ash (8.70-11.14%), hunter lab L (40. ...
DOI:: 10.3920/QAS2016.0863
: https://doi.org/10.3920/QAS2016.0863

88. Concurrent isolation of hepatic stem cells and hepatocytes from the human liver

Author:: Serene M. L. Lee; Cristina Bertinetti-Lapatki; Tobias S. Schiergens; Karl-Walter Jauch; Adrian B. Roth; Wolfgang E. Thasler
Source:: In vitro cellular & developmental biology 2020 v.56 no.3 pp. 253-260
ISSN:: 1071-2690
Subject:: functional properties; hepatocytes; humans; induced pluripotent stem cells; liver; models; phenotype; safety assessment; viability
Abstract:: ... Hepatocytes differentiated from induced pluripotent stem cells or stem cells have the potential to be representative in vitro models of the human liver for research as well as early safety assessment programs. However, up until now, there has been no definitive proof that differentiated hepatocytes recapitulate the phenotype and functional characteristics of primary hepatocytes from the same indiv ...
DOI:: 10.1007/s11626-020-00433-w
PubMed:: 32221840
PubMed Central:: PMC7186250
: https://doi.org/10.1007/s11626-020-00433-w

89. Conductive silk–polypyrrole composite scaffolds with bioinspired nanotopographic cues for cardiac tissue engineering

Author:: Jonathan H. Tsui; Nicholas A. Ostrovsky-Snider; David M. P. Yama; Jordan D. Donohue; Jong Seob Choi; Rakchanok Chavanachat; Jesse D. Larson; Amanda R. MurphyDepartment of Chemistry, Western Washington University, Morse Hall Chemistry Building CB342, Bellingham, WA 98225, USA. E-mail: Amanda.Murphy@wwu.edu; Fax: +1-718-881-2666; Tel: +1-360-650-3138.; Deok-Ho KimDepartment of Bioengineering, University of Washington, Box 355061, Seattle, WA 98195, USA. E-mail: deokho@uw.edu; Fax: +1-206-685-3300; Tel: +1-206-616-1133.
Source:: Journal of materials chemistry B 2018 v.6 no.44 pp. 7185-7196
ISSN:: 2050-7518
Subject:: anisotropy; biomimetics; cell viability; connexins; delamination; electrical conductivity; electrophysiology; extracellular matrix; functional properties; gene expression; humans; nanomaterials; pyrroles; sarcomeres; silk; stem cells; tissue engineering; topography
Abstract:: ... We report on the development of bioinspired cardiac scaffolds made from electroconductive acid-modified silk fibroin–poly(pyrrole) (AMSF + PPy) substrates patterned with nanoscale ridges and grooves reminiscent of native myocardial extracellular matrix (ECM) topography to enhance the structural and functional properties of cultured human pluripotent stem cells (hPSC)-derived cardiomyocytes. Nanopa ...
DOI:: 10.1039/c8tb01116h
PubMed:: 31448124
PubMed Central:: PMC6708520
: https://doi.org/10.1039/c8tb01116h

90. Conformational Entropy as a Determinant of the Thermodynamic Stability of the p53 Core Domain

Author:: Aritra Bej; Juhi A. Rasquinha; Sujoy Mukherjee
Source:: Biochemistry 2018 v.57 no.44 pp. 6265-6269
ISSN:: 1520-4995
Subject:: Gibbs free energy; denaturation; entropy; functional properties; humans; molecular dynamics; mutants; mutation; neoplasms; nuclear magnetic resonance spectroscopy; regression analysis; simulation models; therapeutics; tumor suppressor protein p53; urea
Abstract:: ... Mutations in the core domain of tumor suppressor protein p53 have been associated with ∼50% of the occurrences of human cancers. A majority of these mutations inactivate p53 function by destabilizing its native structure. Although studies have shown p53’s function can be restored by stabilizing the mutants to their wild-type conformation with immense therapeutic potential, its applicability has be ...
DOI:: 10.1021/acs.biochem.8b00740
: https://doi.org/10.1021/acs.biochem.8b00740

91. Conserved functional characteristics of the PIWI family members in chicken germ cell lineage

Author:: T.H. Kim; T.W. Yun; D. Rengaraj; S.I. Lee; S.M. Lim; H.W. Seo; T.S. Park; J.Y. Han
Source:: Theriogenology 2012 v.78 no.9 pp. 1948-1959
ISSN:: 0093-691X
Subject:: RNA interference; genes; ribonucleases; males; gene expression; testes; embryogenesis; females; in situ hybridization; messenger RNA; complementary DNA; humans; mice; stem cells; cDNA libraries; chickens; quantitative polymerase chain reaction; proteins; germ cells; reverse transcriptase polymerase chain reaction; functional properties
Abstract:: ... The P-element-induced wimpy testis (PIWI) protein family, one of two subfamily members of Argonautes that regulate gene expression by associating with small noncoding RNAs, plays a role in maintaining the integrity of germ cells and stem cells. PIWI proteins have been identified and characterized in many species, including humans, mice, and zebrafish, but not as yet in avian species. In this study ...
DOI:: 10.1016/j.theriogenology.2012.07.019
PubMed:: 23058791
: https://doi.org/10.1016/j.theriogenology.2012.07.019

92. Contribution of Cotranslational Folding Defects to Membrane Protein Homeostasis

Author:: Francis J. Roushar; Timothy C. Gruenhagen; Wesley D. Penn; Bian Li; Jens Meiler; Beata Jastrzebska; Jonathan P. Schlebach
Source:: Journal of the American Chemical Society 2018 v.141 no.1 pp. 204-215
ISSN:: 1520-5126
Subject:: biogenesis; functional properties; homeostasis; humans; membrane proteins; models; polypeptides; protein engineering; protein folding; rhodopsin; sequence alignment; topology
Abstract:: ... Membrane proteins are prone to misfolding and degradation within the cell, yet the nature of the conformational defects involved in this process remain poorly understood. The earliest stages of membrane protein folding are mediated by the Sec61 translocon, a molecular machine that facilitates the lateral partitioning of the polypeptide into the membrane. Proper membrane integration is an essential ...
DOI:: 10.1021/jacs.8b08243
PubMed:: 30537820
PubMed Central:: PMC6487503
: https://doi.org/10.1021/jacs.8b08243

93. Contribution of Surface β-Glucan Polysaccharide to Physicochemical and Immunomodulatory Properties of Propionibacterium freudenreichii

Author:: Stéphanie-Marie Deutsch; Sandrine Parayre; Antoine Bouchoux; Fanny Guyomarc'h; Joëlle Dewulf; Marguerite Dols-Lafargue; François Baglinière; Fabien J. Cousin; Hélène Falentin; Gwénaël Jan; Benoît Foligné
Source:: Applied and environmental microbiology 2012 v.78 no.6 pp. 1765-1775
ISSN:: 0099-2240
Subject:: Propionibacterium freudenreichii; anti-inflammatory activity; atomic force microscopy; cheeses; digestive system; functional properties; genes; humans; interleukin-10; mice; mononuclear leukocytes; mutants; physicochemical properties; polystyrenes; probiotics; topography; transmission electron microscopy
Abstract:: ... Propionibacterium freudenreichii is a bacterial species found in Swiss-type cheeses and is also considered for its health properties. The main claimed effect is the bifidogenic property. Some strains were shown recently to display other interesting probiotic potentialities such as anti-inflammatory properties. About 30% of strains were shown to produce a surface exopolysaccharide (EPS) composed of ...
DOI:: 10.1128/AEM.07027-11
PubMed:: 22247154
PubMed Central:: PMC3298172
: https://doi.org/10.1128/AEM.07027-11

94. Controlling the 3D architecture of Self-Lifting Auto-generated Tissue Equivalents (SLATEs) for optimized corneal graft composition and stability

Author:: Ricardo M. Gouveia; Elena González-Andrades; Juan C. Cardona; Carmen González-Gallardo; Ana M. Ionescu; Ingrid Garzon; Miguel Alaminos; Miguel González-Andrades; Che J. Connon
Source:: Biomaterials 2017 v.121 pp. 205-219
ISSN:: 0142-9612
Subject:: absorption; biocompatible materials; biofabrication; collagen; cornea; epithelium; extracellular matrix; functional properties; humans; inflammation; metamorphic rocks; models; phenotype; proteolysis; rabbits; stromal cells
Abstract:: ... Ideally, biomaterials designed to play specific physical and physiological roles in vivo should comprise components and microarchitectures analogous to those of the native tissues they intend to replace. For that, implantable biomaterials need to be carefully designed to have the correct structural and compositional properties, which consequently impart their bio-function. In this study, we showed ...
DOI:: 10.1016/j.biomaterials.2016.12.023
PubMed:: 28092777
PubMed Central:: PMC5267636
: https://doi.org/10.1016/j.biomaterials.2016.12.023

95. Coupling of disulfide bond and distal histidine dissociation in human ferrous cytoglobin regulates ligand binding

Author:: Penny Beckerson; Brandon J. Reeder; Michael T. Wilson
Source:: FEBS letters 2015 v.589 no.4 pp. 507-512
ISSN:: 0014-5793
Subject:: cysteine; dissociation; disulfide bonds; functional properties; histidine; humans; ligands; models; mutants; photolysis
Abstract:: ... Earlier kinetics studies on cytoglobin did not assign functional properties to specific structural forms. Here, we used defined monomeric and dimeric forms and cysteine mutants to show that an intramolecular disulfide bond (C38–C83) alters the dissociation rate constant of the intrinsic histidine (H81) (∼1000fold), thus controlling binding of extrinsic ligands. Through time-resolved spectra we hav ...
DOI:: 10.1016/j.febslet.2015.01.010
: https://doi.org/10.1016/j.febslet.2015.01.010

96. Cow’s milk as a dietary source of equol and phenolic antioxidants: differential distribution in the milk aqueous and lipid fractions

Author:: Shin Yih Tsen; Jinyi Siew; Eunice Kai Ling Lau; Farzana Afiqah bte Roslee; Hui Mei Chan; Wai Mun Loke
Source:: Dairy science & technology 2014 v.94 no.6 pp. 625-632
ISSN:: 1958-5586
Subject:: antioxidant activity; antioxidants; bacteria; correlation; cows; daidzein; digestive system; functional properties; humans; metabolites; milk; neutrophils; nutritive value; phenolic compounds
Abstract:: ... Cow’s milk contains bioactive secondary phenolic compounds that are formed by bovine’s gut bacterial flora from plant phenolic compounds. Equol, a metabolite of daidzein, is one such secondary compounds of biological interest. The potential of phenolic compounds in milk as dietary antioxidants and their distribution within the milk matrix were examined. The equol concentrations, total phenolic con ...
DOI:: 10.1007/s13594-014-0183-4
: https://doi.org/10.1007/s13594-014-0183-4

97. Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction

Author:: Astrid Borchert; Jacqueline Kalms; Sophia R. Roth; Marlena Rademacher; Andrea Schmidt; Hermann-Georg Holzhutter; Hartmut Kuhn; Patrick Scheerer
Source:: Biochimica et biophysica acta 2018 v.1863 no.9 pp. 1095-1107
ISSN:: 1388-1981
Subject:: Escherichia coli; X-radiation; alcohols; crystal structure; electrophoresis; enzymology; functional properties; genes; glutathione; glutathione peroxidase; humans; hydroperoxides; mice; phospholipid-hydroperoxide glutathione peroxidase; phospholipids; reaction mechanisms; selenium; selenocysteine; selenoproteins; transgenic animals
Abstract:: ... Glutathione peroxidases (GPX) are anti-oxidative enzymes that reduce organic and inorganic hydroperoxides to the corresponding alcohols at the expense of reduced glutathione. The human genome involves eight GPX genes and five of them encode for selenocysteine-containing enzymes. Among the human GPX-isoforms, GPX4 is unique since it is capable of reducing complex hydroperoxy ester lipids such as hy ...
DOI:: 10.1016/j.bbalip.2018.06.006
: https://doi.org/10.1016/j.bbalip.2018.06.006

98. Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution

Author:: Manish Kumar Thakur; Amit Kumar; Swarnakumari Birudukota; Srinivasan Swaminathan; Rajiv Tyagi; Ramachandraiah Gosu
Source:: Biochemical and biophysical research communications 2016 v.478 no.2 pp. 637-642
ISSN:: 0006-291X
Subject:: X-ray diffraction; ambient temperature; breast neoplasms; cell lines; crystal structure; databases; functional properties; humans; mammary glands; molecular cloning; neoplasm cells; solvents; therapeutics; tyrosine
Abstract:: ... Human Protein tyrosine kinase 6 (PTK6) (EC:2.7.10.2), also known as the breast tumor kinase (BRK), is an intracellular non-receptor Src-related tyrosine kinase expressed in a majority of human breast tumors and breast cancer cell lines, but its expression is low or completely absent in normal mammary glands. In the recent past, several studies have suggested that PTK6 is a potential therapeutic ta ...
DOI:: 10.1016/j.bbrc.2016.07.121
: https://doi.org/10.1016/j.bbrc.2016.07.121

99. Crystal structure of the rigor-like human non-muscle myosin-2 motor domain

Author:: Stefan Münnich; Salma Pathan-Chhatbar; Dietmar J. Manstein
Source:: FEBS letters 2014 v.588 no.24 pp. 4754-4760
ISSN:: 0014-5793
Subject:: actin; active sites; crystal structure; functional properties; humans; mutation; myosin
Abstract:: ... We determined the crystal structure of the motor domain of human non-muscle myosin 2B (NM-2B) in a nucleotide-free state and at a resolution of 2.8Å. The structure shows the motor domain with an open active site and the large cleft that divides the 50kDa domain in a closed state. Compared to other rigor-like myosin motor domain structures, our structure shows subtle but significant conformational ...
DOI:: 10.1016/j.febslet.2014.11.007
: https://doi.org/10.1016/j.febslet.2014.11.007

100. Current and Future Technologies for Microbiological Decontamination of Cereal Grains

Author:: Agata Los; Dana Ziuzina; Paula Bourke
Source:: Journal of food science 2018 v.83 no.6 pp. 1484-1493
ISSN:: 0022-1147
Subject:: decontamination; food safety; functional properties; human health; humans; microorganisms; mycotoxins; pesticides; population growth; risk; small cereal grains; staple foods
Abstract:: ... Cereal grains are the most important staple foods for mankind worldwide. The constantly increasing annual production and yield is matched by demand for cereals, which is expected to increase drastically along with the global population growth. A critical food safety and quality issue is to minimize the microbiological contamination of grains as it affects cereals both quantitatively and qualitativ ...
DOI:: 10.1111/1750-3841.14181
: https://doi.org/10.1111/1750-3841.14181

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1. 3D structure/function analysis of PilX reveals how minor pilins can modulate the virulence properties of type IV pili

2. 71. Cryopreservation of in vitroshoot-tips of a sweet potato Famaillá 6 clone (Ipomoea batatas (L.) Lam.) by droplet-vitrification technique

3. A Peptide Derived from Bovine β-Casein Modulates Functional Properties of Bone Marrow-Derived Macrophages from Germfree and Human Flora-Associated Mice

4. A Pursuit of the Functional Nutritional and Bioactive Properties of Canola Proteins and Peptides

5. A Review on Osmotic Dehydration of Fruits and Vegetables: An Integrated Approach

6. A Tn antigen binding lectin from Myrsine coriacea displays toxicity in human cancer cell lines

7. A bacterial 2[4Fe4S] ferredoxin as redox partner of the plastidic-type ferredoxin-NADP+ reductase from Leptospira interrogans

8. A biological trait approach to assess the functional composition of subtidal benthic communities in an estuarine ecosystem

9. A compendium of human genes regulating feeding behavior and body weight, its functional characterization and identification of GWAS genes involved in brain-specific PPI network

10. A compendium on single‐cell analysis for the curious

11. A functionally conserved member of the FTZâF1 nuclear receptor family from Schistosoma mansoni

12. A microfluidically perfused three dimensional human liver model

13. A newly isolated probiotic Enterococcus faecalis strain from vagina microbiota enhances apoptosis of human cancer cells

14. A novel Kir7.1 splice variant expressed in various mouse tissues shares organisational and functional properties with human Leber amaurosis-causing mutations of this K+ channel

15. A novel bovine serum albumin and sodium alginate hydrogel scaffold doped with hydroxyapatite nanowires for cartilage defects repair

16. A novel non-integrative single-cycle chimeric HIV lentivector DNA vaccine

17. A novel splice variant of supervillin, SV5, promotes carcinoma cell proliferation and cell migration

18. A review: Health promoting lactic acid bacteria in traditional Indonesian fermented foods

19. A simple method of surface functionalisation for immuno-specific immobilisation of proteins

20. AIDS-protective HLA-B*27/B*57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz

21. Advances in Studies Using Vegetable Wastes to Obtain Pectic Substances: A Review

22. Age-related changes in memory and effector T cells responding to influenza A/H3N2 and pandemic A/H1N1 strains in humans

23. Alginate/PVA Beads for Levan Production by Zymomonas mobilis

24. Altered response of fibroblasts from human tympanosclerotic membrane to interacting mast cells: Implication for tissue remodeling

25. An overview of plant-autochthonous microorganisms and fermented vegetable foods

26. An overview of separation methods in starch analysis: The importance of size exclusion chromatography and field flow fractionation

27. Analysis of CD161 expression on human CD8⁺ T cells defines a distinct functional subset with tissue-homing properties

28. Analysis of Calcium Transients and Uniaxial Contraction Force in Single Human Embryonic Stem Cell-Derived Cardiomyocytes on Microstructured Elastic Substrate with Spatially Controlled Surface Chemistries

29. Analysis of Single-Nucleotide Polymorphisms in Human Voltage-Gated Ion Channels

30. Analysis of adenovirus-induced immunity to infection with Listeria monocytogenes: Fading protection coincides with declining CD8 T cell numbers and phenotypic changes

31. Analysis of functional properties of biologically active substances using eukaryotic cell models (review)

32. Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells, monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics

33. Angiogenin Promotes Hematopoietic Regeneration by Dichotomously Regulating Quiescence of Stem and Progenitor Cells

34. Antagonistic effect of chitinolytic Pseudomonas and Bacillus on growth of fungal hyphae and spores of aflatoxigenic Aspergillus flavus

35. Antioxidant and anticancer effects of functional peptides from ovotransferrin hydrolysates

36. Antioxidant, angiotensin-converting enzyme inhibitory activity and other functional properties of egg white proteins and their derived peptides – A review

37. Application and bioactive properties of proteins and peptides derived from hen eggs: opportunities and challenges

38. Application of diagnosticum based on functionalized carbon nanoparticles for monitoring of immunoglobulins affinity purification

39. Artificial structures alter kelp functioning across an urbanised estuary

40. Association of human tumor necrosis factor‐related apoptosis inducing ligand with membrane upon acidification

41. Barley yellow dwarf viruses (BYDVs) preserved in herbarium specimens illuminate historical disease ecology of invasive and native grasses

42. Beyond spectral tuning: human cone visual pigments adopt different transient conformations for chromophore regeneration

43. Bioactive properties and functional constituents of Hypericum androsaemum L.: A focus on the phenolic profile

44. Bioactivity of soy-based fermented foods: A review

45. Bioinspired multilayer membranes as potential adhesive patches for skin wound healing

46. Biomechanical and functional properties of trophoblast cells exposed to Group B Streptococcus in vitro and the beneficial effects of uvaol treatment

47. Biomimetic LBL structured nanofibrous matrices assembled by chitosan/collagen for promoting wound healing

48. Biomimetic cardiovascular platforms for in vitro disease modeling and therapeutic validation

49. Biopolymer-based coacervates: Structures, functionality and applications in food products

50. Bioprocessing of human mesenchymal stem/stromal cells for therapeutic use: Current technologies and challenges

51. Biosynthesis of dextran by Weissella confusa and its In vitro functional characteristics

52. Bispecific Anti-HIV-1 Antibodies with Enhanced Breadth and Potency

53. Black Pepper and Health Claims: A Comprehensive Treatise

54. Bovine herpesvirus glycoprotein D: a review of its structural characteristics and applications in vaccinology

55. C-termini are essential and distinct for nucleic acid binding of human NABP1 and NABP2

56. CD11c⁺ Cells are Significantly Decreased in the Duodenum, Ileum and Colon of Dogs with Inflammatory Bowel Disease

57. CD27 expression discriminates porcine T helper cells with functionally distinct properties

58. CLERC and centrosomal leucine-rich repeat proteins

59. Calmodulin mutations causing catecholaminergic polymorphic ventricular tachycardia confer opposing functional and biophysical molecular changes

60. Camu-camu seed (Myrciaria dubia) – From side stream to an antioxidant, antihyperglycemic, antiproliferative, antimicrobial, antihemolytic, anti-inflammatory, and antihypertensive ingredient

61. Canine and human sinoatrial node: differences and similarities in the structure, function, molecular profiles, and arrhythmia

62. Cardiac tissue engineering using tissue printing technology and human cardiac progenitor cells

63. Cardioprotective properties of grape seed proanthocyanidins: An update

64. Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage

65. Characteristics and Nutritional and Cardiovascular-Health Properties of Seaweeds

66. Characteristics of One Health surveillance systems: A systematic literature review

67. Characterization of Human Fungiform Papillae Cells in Culture

68. Characterization of casein and alpha lactalbumin of African elephant (Loxodonta africana) milk

69. Characterization of dextran-grafted hydrophobic charge-induction resins: Structural properties, protein adsorption and transport

70. Characterization of functional properties of Enterococcus faecium strains isolated from human gut

11. A functionally conserved member of the FTZâF1 nuclear receptor family from Schistosoma mansoni

20. AIDS-protective HLA-B27/B57 and chimpanzee MHC class I molecules target analogous conserved areas of HIV-1/SIVcpz