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- Author:
- Marina Jovanović; Snežana Zlatanović; Darko Micić; Dragan Bacić; Dragana Mitić-Ćulafić; Mihal Đuriš; Stanislava Gorjanović
- Source:
- Foods 2021 v.10 no.8 pp. -
- ISSN:
- 2304-8158
- Subject:
- Beta vulgaris; Escherichia coli; Streptococcus thermophilus; antibacterial properties; antineoplastic activity; antioxidants; beets; cell viability; cold storage; colorectal neoplasms; compressibility; consumer attitudes; cultured milk starters; dietary fiber; dogs; fermented beverages; flour; fluidized beds; food acceptability; food fortification; fortified foods; functional foods; functional properties; granules; humans; lactic acid bacteria; lactose; neoplasm cells; palatability; particle size; pomace; storage quality; storage time; yogurt
- Abstract:
- ... Following the idea of sustainability in food production, a yogurt premix based on beetroot (Beta vulgaris) pomace flour (BPF) was developed. BPF was granulated with lactose solution containing lactic acid bacteria (LAB) by a fluidized bed. Particle size increased ~30%. A decrease in Carr Index from 21.5 to 14.98 and Hausner ratio from 1.27 to 1.18 confirmed improved flowability of granulated BPF, ...
- DOI:
- 10.3390/foods10081696
- https://doi.org/10.3390/foods10081696
- Author:
- Shiv Shankar; Lily Jaiswal; Jong-Whan Rhim
- Source:
- Critical reviews in environmental science and technology 2021 v.51 no.20 pp. 2329-2356
- ISSN:
- 1547-6537
- Subject:
- antineoplastic activity; environmental science; humans; mechanism of action; sulfur
- Abstract:
- ... Recently, interest in sulfur nanoparticles (SNPs) and their applications in food, agriculture, and biomedical fields have increased mainly due to the significant antibacterial and anticancer activity of these nanomaterials. However, with these applications, there is a growing concern regarding the biological effects and the possible risks to the environment and health by the use of sulfur nanopart ...
- DOI:
- 10.1080/10643389.2020.1780880
- https://doi.org/10.1080/10643389.2020.1780880
- Author:
- Huifang Yuan; Xiaoyan Zheng; Wan Liu; Hui Zhang; Jingjing Shao; Jiaxin Yao; Chunyi Mao; Junfeng Hui; Daidi Fan
- Source:
- Colloids and surfaces 2020 v.192 pp. 111041
- ISSN:
- 0927-7765
- Subject:
- bioactive properties; biocompatibility; biocompatible materials; biomimetics; bone marrow; bovine serum albumin; cartilage; functional properties; humans; hydrogels; hydroxyapatite; in vivo studies; mesenchymal stromal cells; nanowires; porosity; sodium alginate; strength (mechanics); tissue engineering
- Abstract:
- ... Cartilage tissue engineering has become the trend of cartilage defect repair owing to the engineered biomimetic tissue that can mimic the structural, biological and functional characteristics of natural cartilage. Biomaterials with high biocompatibility and regeneration capacity are expected to be used in cartilage tissue engineering. Herein, in this study, a dual-network bovine serum albumin/sodi ...
- DOI:
- 10.1016/j.colsurfb.2020.111041
- https://doi.org/10.1016/j.colsurfb.2020.111041
- Author:
- Sebastian Torres; Hernán Verón; Luciana Contreras; Maria I. Isla
- Source:
- Food science and human wellness 2020 v.9 no.2 pp. 112-123
- ISSN:
- 2213-4530
- Subject:
- beverages; fermentation; fermented vegetables; fruits; functional properties; human health; humans; microorganisms; plant-based foods; shelf life; starter cultures; vegetables
- Abstract:
- ... Fermented plant-based foods and beverages constitute foods of high nutritional and functional value with appreciated health beneficial effects. They represent a natural and sustainable alternative to counteract the large wastage of vegetables and fruits due to their short shelf life. Usually, the use of controlled fermentation process using autochthonous microorganisms adapted to their vegetable m ...
- DOI:
- 10.1016/j.fshw.2020.02.006
- https://doi.org/10.1016/j.fshw.2020.02.006
- Author:
- Marina Fidelis; Mariana Araújo Vieira do Carmo; Thiago Mendanha da Cruz; Luciana Azevedo; Takao Myoda; Marianna Miranda Furtado; Mariza Boscacci Marques; Anderson S. Sant'Ana; Maria Inês Genovese; Won Young Oh; Mingchun Wen; Fereidoon Shahidi; Liang Zhang; Marcelo Franchin; Severino Matias de Alencar; Pedro Luiz Rosalen; Daniel Granato
- Source:
- Food chemistry 2020 v.310 pp. 125909
- ISSN:
- 0308-8146
- Subject:
- Myrciaria dubia; alpha-amylase; alpha-glucosidase; antihypertensive effect; antimicrobial properties; antioxidant activity; antioxidants; bioactive compounds; bioassays; cell culture; copper; cytotoxicity; enzyme inhibition; erythrocytes; functional properties; glycemic effect; hemolysis; humans; ingredients; low density lipoprotein; macrophages; neoplasm cells; neoplasms; oxidation; phenolic compounds; seeds; solvents; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Camu-camu (Myrciaria dubia) seeds are discarded without recovering the bioactive compounds. The main aim of the present work was to optimise the solvent mixture to extract higher total phenolic content and antioxidant capacity of camu-camu seeds. The optimised solvent system increased the extraction of phenolic compounds, in which vescalagin and castalagin were the main compounds. The optimised ex ...
- DOI:
- 10.1016/j.foodchem.2019.125909
- https://doi.org/10.1016/j.foodchem.2019.125909
- Author:
- Marion Bordier; Theethawat Uea-Anuwong; Aurélie Binot; Pascal Hendrikx; Flavie L. Goutard
- Source:
- Preventive veterinary medicine 2020 v.181 pp. 104560
- ISSN:
- 0167-5877
- Subject:
- One Health initiative; cost effectiveness; databases; environmental health; functional properties; governance; guidelines; health hazards; humans; monitoring; screening; stakeholders; uncertainty
- Abstract:
- ... The concept of One Health (OH) promotes the decompartmentalisation of human, animal, and ecosystem health for the more efficient and sustainable governance of complex health issues. This means that traditional boundaries between disciplines and sectors must be transgressed and that all relevant stakeholders must be involved in the definition and management of health problems. International efforts ...
- DOI:
- 10.1016/j.prevetmed.2018.10.005
- https://doi.org/10.1016/j.prevetmed.2018.10.005
- Author:
- Fernanda R.L. Rolim; Oliveiro C. Freitas Neto; Maria Elieidy G. Oliveira; Celso J.B. Oliveira; Rita C.R.E. Queiroga
- Source:
- Trends in food science & technology 2020 v.100 pp. 138-154
- ISSN:
- 0924-2244
- Subject:
- buffering capacity; cheeses; clinical trials; food matrix; foods; functional properties; humans; in vitro studies; in vivo studies; intestinal mucosa; mechanism of action; nutrient availability; oxygen; pH; probiotics; sensory properties; shelf life; viability
- Abstract:
- ... Probiotics are microorganisms that promote beneficial health effects. To do this, they must survive passage through the gastrointestinal tract, adhere and colonize in the intestinal epithelium. Foods are vehicles that protect these strains during this passage, in particular cheese, which has advantages such as availability of nutrients, high pH, higher buffering capacity and low oxygen content. Th ...
- DOI:
- 10.1016/j.tifs.2020.04.008
- https://doi.org/10.1016/j.tifs.2020.04.008
- Author:
- Atif B.A. Mohammed; Sakina Yagi; Tzvetomira Tzanova; Hervé Schohn; Haider Abdelgadir; Azzurra Stefanucci; Adriano Mollica; Mohamad Fawzi Mahomoodally; Talal A. Adlan; Gökhan Zengin
- Source:
- South African journal of botany 2020 v.132 pp. 403-409
- ISSN:
- 0254-6299
- Subject:
- Ocimum basilicum; Pulicaria undulata; acarbose; acetylcholinesterase; adenocarcinoma; alpha-amylase; antioxidant activity; antioxidants; assays; breast neoplasms; cell lines; cell viability; chemical composition; cholinesterase; colon; computer simulation; cosmetics; enzyme activity; enzyme inhibition; essential oils; free radicals; functional properties; gas chromatography-mass spectrometry; humans; ions; linalool; methyl chavicol; oils; pharmaceutical industry; stems; Sudan
- Abstract:
- ... In the present study, essential oils extracted from the leafy stems of Ocimum basilicum (Family Lamiaceae) and Pulicaria undulata (Family Asteraceae) were investigated for their chemical profiles and biological activity including antioxidant, antiproliferative and enzyme inhibition activities. The chemical composition of essential oil was determined using Gas Chromatography-Mass Spectrometry. The ...
- DOI:
- 10.1016/j.sajb.2020.06.006
- https://doi.org/10.1016/j.sajb.2020.06.006
- Author:
- Graziela Bragueto Escher; Mariza Boscacci Marques; Mariana Araújo Vieira do Carmo; Luciana Azevedo; Marianna Miranda Furtado; Anderson S. Sant'Ana; Marcia Cristina da Silva; Maria Inês Genovese; Mingchun Wen; Liang Zhang; Won Young Oh; Fereidoon Shahidi; Neiva Deliberali Rosso; Daniel Granato
- Source:
- Food research international 2020 v.128 pp. 108763
- ISSN:
- 0963-9969
- Subject:
- Clitoria ternatea; DNA; absorption; alpha-amylase; alpha-glucosidase; antihypertensive effect; antimicrobial properties; antioxidant activity; bioactive compounds; cell lines; cleavage (chemistry); corolla; cytotoxicity; enzyme activity; enzyme inhibition; erythrocytes; freeze drying; functional properties; hemolysis; humans; inhibitory concentration 50; lethal concentration 50; lipid peroxidation; low density lipoprotein cholesterol; oxidation; phenolic compounds; principal component analysis; protective effect; reactive oxygen species; temperature
- Abstract:
- ... The purpose of this study was to use a statistical approach to optimise the experimental conditions regarding the extraction of bioactive compounds, and to analyse the in vitro functional properties of crude lyophilized extracts (CLE) and partially purified (PPE) extracts of Clitoria ternatea petals. The results showed that the factors of temperature and time influenced the extraction of phenolic ...
- DOI:
- 10.1016/j.foodres.2019.108763
- https://doi.org/10.1016/j.foodres.2019.108763
- Author:
- Serene M. L. Lee; Cristina Bertinetti-Lapatki; Tobias S. Schiergens; Karl-Walter Jauch; Adrian B. Roth; Wolfgang E. Thasler
- Source:
- In vitro cellular & developmental biology 2020 v.56 no.3 pp. 253-260
- ISSN:
- 1071-2690
- Subject:
- functional properties; hepatocytes; humans; induced pluripotent stem cells; liver; models; phenotype; safety assessment; viability
- Abstract:
- ... Hepatocytes differentiated from induced pluripotent stem cells or stem cells have the potential to be representative in vitro models of the human liver for research as well as early safety assessment programs. However, up until now, there has been no definitive proof that differentiated hepatocytes recapitulate the phenotype and functional characteristics of primary hepatocytes from the same indiv ...
- DOI:
- 10.1007/s11626-020-00433-w
- PubMed:
- 32221840
- PubMed Central:
- PMC7186250
- https://doi.org/10.1007/s11626-020-00433-w
- Author:
- Amal Z. Barakat; Ahmed R. Hamed; Roqaya I. Bassuiny; Azza M. Abdel-Aty; Saleh A. Mohamed
- Source:
- Journal of food measurement & characterization 2020 v.14 no.2 pp. 1064-1072
- ISSN:
- 2193-4126
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Phoenix dactylifera; Serenoa repens; acetone; agroindustrial byproducts; anti-inflammatory activity; antibacterial properties; antifungal properties; antioxidant activity; antioxidants; bioactive compounds; enzyme inhibition; ethanol; flavonoids; functional properties; fungi; high performance liquid chromatography; humans; inducible nitric oxide synthase; inflammation; inhibitory concentration 50; minimum inhibitory concentration; multiple drug resistance; nitric oxide; protein synthesis; protocatechuic acid; seeds
- Abstract:
- ... The agricultural by-products are a significant source of health benefiting bioactive compounds. In this trend, the phenolic and flavonoid contents and functional properties of date palm seeds (DPS) and saw palmetto seeds (SPS) extracts were evaluated in this study. Considerable phenolic and flavonoid contents of 11.8, 7.75 mg GAE/g seed and 3.13, 1.1 mg CE/g seed were detected in DPS ethanol and S ...
- DOI:
- 10.1007/s11694-019-00356-5
- https://doi.org/10.1007/s11694-019-00356-5
- Author:
- Nidhi Joshi; Nupur Nagar; Khushboo Gulati; Krishnakant Gangele; Amit Mishra; Dinesh Kumar; Krishna Mohan Poluri
- Source:
- International journal of biological macromolecules 2020 v.156 pp. 239-251
- ISSN:
- 0141-8130
- Subject:
- Primates; Rodentia; cell movement; chemokine CCL2; comparative study; computer simulation; evolution; functional properties; glycosaminoglycans; glycosylation; humans; mice; monocytes; nuclear magnetic resonance spectroscopy; proteins
- Abstract:
- ... Chemokines are a sub-group of cytokines that regulate the leukocyte migration. Monocyte chemoattractant protein-1 (MCP/CCL2) is one of the essential CC chemokine that regulates the migration of monocytes into inflamed tissues. It has been observed that the primary sequences of CCL2 orthologs among rodents and primates vary significantly at the C-terminal region. However, no structural details are ...
- DOI:
- 10.1016/j.ijbiomac.2020.04.067
- https://doi.org/10.1016/j.ijbiomac.2020.04.067
- Author:
- Merve Çapkın Yurtsever; Arlin Kiremitci; Menemşe Gümüşderelioğlu
- Source:
- Journal of photochemistry and photobiology 2020 v.204 pp. 111742
- ISSN:
- 1011-1344
- Subject:
- brain; cell death; cell lines; culture media; diodes; dopamine; energy density; functional properties; humans; laminin; messenger RNA; near infrared radiation; neuroglia; neurons; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; stem cells; tooth pulp
- Abstract:
- ... Human dental pulp stem cells (hDPSCs) are able to differentiate into dopaminergic neurons and help the maintenance of partially degenerated neurons, which makes them as an alternative cell source for treatment of Parkinsons' disease (PD) patients. Here, the effect of photobiomodulation with polychromatic light source in the near infrared (NIR) range (600–1200 nm) or low level 660 nm diode laser li ...
- DOI:
- 10.1016/j.jphotobiol.2019.111742
- https://doi.org/10.1016/j.jphotobiol.2019.111742
- Author:
- Benjamin K. Mintah; Ronghai He; Akwasi A. Agyekum; Mokhtar Dabbour; Moses K. Golly; Haile Ma
- Source:
- Journal of food process engineering 2020 v.43 no.4 pp. e13362
- ISSN:
- 0145-8876
- Subject:
- Hermetia illucens; amino acids; edible insects; experimental design; fluorescence; functional properties; humans; industry; insect larvae; insect proteins; mathematical models; pests; protein composition; protein isolates; protein sources; response surface methodology
- Abstract:
- ... This study sought to establish an optimized procedure for extraction of protein from microwave‐dried larvae of an edible insect, Hermetia illucens (HIL), and to determine and compare the amino acid (AA) component, intrinsic fluorescence (IF), and physicochemical/functional properties (PFPs) of protein isolates. Box–Behnken's design with the Box–Wilson methodology was applied in the optimization pr ...
- DOI:
- 10.1111/jfpe.13362
- https://doi.org/10.1111/jfpe.13362
- Author:
- Snježana Radulović; Benjamin Gottschalk; Gerd Hörl; Pablo Zardoya-Laguardia; Irene Schilcher; Seth Hallström; Nemanja Vujić; Kurt Schmidt; Markus Trieb; Wolfgang F. Graier; Roland Malli; Dagmar Kratky; Gunther Marsche; Saša Frank
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.4 pp. 158612
- ISSN:
- 1388-1981
- Subject:
- acyl coenzyme A; blood serum; carboxylic ester hydrolases; cholesterol; cholesterol acyltransferase; endothelial nitric oxide synthase; enzyme activity; filipin; functional properties; high density lipoprotein; human cell lines; humans; mice; microscopy; mitochondria; phosphorylation; plasma membrane; thin layer chromatography; vasodilation; viruses
- Abstract:
- ... Endothelial lipase (EL) changes structural and functional properties of high-density lipoprotein (HDL). HDL is a relevant modulator of endothelial nitric oxide synthase (eNOS) activity, but the effect of EL on HDL induced eNOS-activation has not yet been investigated. Here, we examined the impact of EL-modified HDL (EL-HDL) on eNOS activity, subcellular trafficking, and eNOS- dependent vasorelaxat ...
- DOI:
- 10.1016/j.bbalip.2020.158612
- https://doi.org/10.1016/j.bbalip.2020.158612
- Author:
- Yu Zhang; Hazel Bracken; Cheryl Woolhead; Michele Zagnoni
- Source:
- Biosensors & bioelectronics 2020 v.150 pp. 111920
- ISSN:
- 0956-5663
- Subject:
- biosensors; chlorides; droplets; electrophysiology; fluorescence; functional properties; geometry; hemolysins; humans; ion channels; lipid bilayers; oligomerization
- Abstract:
- ... Profiling ion flux through human intracellular chloride ion channels using live-cell based techniques, such as patch-clamp electrophysiology, is laborious and time-consuming. The integration of scalable microfluidic systems with automatable protocols based on droplet-interface-bilayers (DIBs) within which ion channels are incorporated circumvents several limitations associated with live-cell measu ...
- DOI:
- 10.1016/j.bios.2019.111920
- https://doi.org/10.1016/j.bios.2019.111920
- Author:
- Diana Rocha-Mendoza; Erica Kosmerl; Gonzalo Miyagusuku-Cruzado; M. Mónica Giusti; Rafael Jiménez-Flores; Israel García-Cano
- Source:
- Journal of dairy science 2020 v.103 no.9 pp. 7707-7718
- ISSN:
- 0022-0302
- Subject:
- Lactobacillus paracasei; Lactobacillus reuteri; Pediococcus acidilactici; absorbance; adhesion; bacterial adhesion; bile salts; digestive system; fermentation; food composition; functional properties; gene expression; genes; human cell lines; human health; humans; hydrophobicity; lactic acid bacteria; microbiome; milk; pH; phospholipids; probiotics; sugars; surface proteins
- Abstract:
- ... The mechanisms of bacterial adhesion to human cells involve several complex reactions and activation of genes and proteins. It has been reported that the food components in dairy matrices, such as sugar or salt, can decrease bacterial adhesion to Caco-2 cells. However, it has not been evaluated whether the bacteria grown in media supplemented with milk phospholipids (MPL) can increase or decrease ...
- DOI:
- 10.3168/jds.2020-18271
- https://doi.org/10.3168/jds.2020-18271
- Author:
- Takao Nagano; Yuya Arai; Hiromi Yano; Takafumi Aoki; Shin Kurihara; Rika Hirano; Katsuyoshi Nishinari
- Source:
- Food hydrocolloids 2020 v.109 pp. 105964
- ISSN:
- 0268-005X
- Subject:
- adverse effects; alpha-amylase; atomization; cellulose; cellulose nanofibers; contact dermatitis; dietary fiber; dietary supplements; enzyme activity; exercise; functional properties; healthy diet; high fat diet; humans; hydrocolloids; intestinal microorganisms; isoflavones; mice; nutritive value; obesity; okara; physicochemical properties; short chain fatty acids; soybeans; soymilk; surface area; texture; therapeutics; tofu; viscosity
- Abstract:
- ... Okara, the residue of the production of tofu and soybean milk, is rich in dietary fibers (DFs) and phytochemical components such as soy isoflavones (SIs) and soyasaponins (SSs). Despite its nutritive value, okara is scarcely used as a food source as the DFs in okara are mostly insoluble and have adverse effects on food texture. Thus, it is necessary to improve the physicochemical properties of oka ...
- DOI:
- 10.1016/j.foodhyd.2020.105964
- https://doi.org/10.1016/j.foodhyd.2020.105964
- Author:
- Cláudia Amorim; Sara C. Silvério; Beatriz B. Cardoso; Joana I. Alves; Maria Alcina Pereira; Lígia R. Rodrigues
- Source:
- Lebensmittel-Wissenschaft + Technologie 2020 v.126 pp. 109322
- ISSN:
- 0023-6438
- Subject:
- Bifidobacterium; Lactobacillus; Proteobacteria; ammonia; carbon dioxide; fermentation; functional properties; high-throughput nucleotide sequencing; human health; humans; ingredients; inoculum; intestinal microorganisms; lactic acid; lactulose; models; pH; prebiotics; raffinose; short chain fatty acids; volunteers
- Abstract:
- ... Until now the prebiotic potential of pure trisaccharide raffinose on human health assessed through high-throughput sequencing remains poorly investigated. In this work, an in vitro model using human fecal inocula of two healthy volunteers (D1 and D2) was used to study the prebiotic potential of raffinose and compare it with the well-stablished and commercial prebiotic lactulose. The intestinal mic ...
- DOI:
- 10.1016/j.lwt.2020.109322
- https://doi.org/10.1016/j.lwt.2020.109322
- Author:
- Nabil Smichi; Goetz Parsiegla; Neila Achouri; Zied Zarai; Abdelkarim Abousalham; Ahmed Fendri
- Source:
- International journal of biological macromolecules 2020 v.143 pp. 881-890
- ISSN:
- 0141-8130
- Subject:
- Diplodus sargus sargus; Escherichia coli; Sparus aurata; amino acids; catalytic activity; cell membranes; computer simulation; cytotoxicity; fish; functional properties; humans; inclusion bodies; intestines; lipid metabolism; macrophages; models; phosphatidylcholines; phospholipase A2; phospholipases; proteins; sequence analysis; thermal stability
- Abstract:
- ... Marine species have gained significant attention as potential source for a broad spectrum of bioactive proteins. Fish phospholipases A₂ (PLA₂) have attracted renewed interest due to their excellent properties in lipid digestion. Herein, we report for the first time the catalytic properties of two intestinal secreted PLA₂ (sPLA₂) identified from Diplodus sargus (IDsPLA₂) and Sparus aurata (ISaPLA₂) ...
- DOI:
- 10.1016/j.ijbiomac.2019.09.149
- https://doi.org/10.1016/j.ijbiomac.2019.09.149
- Author:
- Keyu Tao; Wenwen Yu; Sangeeta Prakash; Robert G. Gilbert
- Source:
- Food science and human wellness 2020 v.9 no.2 pp. 130-135
- ISSN:
- 2213-4530
- Subject:
- amylose; consumer preferences; diabetes; foods; functional properties; gelatinization; hardness; humans; neoplasms; obesity; rice; screening; sensory evaluation; sensory properties; stickiness; swelling (materials); texture; viscosity
- Abstract:
- ... Foods wherein the starch is slowly digested contribute to good health by reducing the tendency to, and for the maintenance of, diabetes, obesity and colo-rectal cancers. While foods with high amylose content have this desirable property, they usually do not have high sensory appeal and consumers are reluctant to eat them. While sensory evaluation by trained human panelists is the best way to obtai ...
- DOI:
- 10.1016/j.fshw.2020.02.001
- https://doi.org/10.1016/j.fshw.2020.02.001
- Author:
- Qiwei Ma; Zhaoya Gong; Jing Kang; Ran Tao; Anrong Dang
- Source:
- Remote Sensing 2020 v.12 no.16 pp. -
- ISSN:
- 2072-4292
- Subject:
- Landsat; case studies; cell communication; cities; dimensions; functional properties; geographic information systems; habitat fragmentation; humans; land surveying; land use; planning; population; remote sensing; shrinkage; surveys; urban areas; validity; China
- Abstract:
- ... Most of the shrinking cities experience an unbalanced deurbanization across different urban areas in cities. However, traditional ways of measuring urban shrinkage are focused on tracking population loss at the city level and are unable to capture the spatially heterogeneous shrinking patterns inside a city. Consequently, the spatial mechanism and patterns of urban shrinkage inside a city remain l ...
- DOI:
- 10.3390/rs12162513
- https://doi.org/10.3390/rs12162513
- Author:
- Delfine Cheng; Marco Morsch; Gerald J. Shami; Roger S. Chung; Filip Braet
- Source:
- Micron 2020 v.132 pp. 102851
- ISSN:
- 0968-4328
- Subject:
- Danio rerio; Kupffer cells; functional properties; genetics; hepatocytes; humans; image analysis; innate immunity; liver; models; pseudopodia; rodents; wastes
- Abstract:
- ... Kupffer cells are liver-resident macrophages that play an important role in mediating immune-related functions in mammals and humans. They are well-known for their capacity to phagocytose large amounts of waste complexes, cell debris, microbial particles and even malignant cells. Location, appearance and functional aspects are important features used to identify these characteristic cells of the l ...
- DOI:
- 10.1016/j.micron.2020.102851
- https://doi.org/10.1016/j.micron.2020.102851
- Author:
- Tayler L. Hansen; Ellen M. Rankins; Jill M. Bobel; Meagan McKinney; Timothy J. Hackmann; Lori K. Warren
- Source:
- Journal of equine veterinary science 2020 v.88 pp. 102963
- ISSN:
- 0737-0806
- Subject:
- Dactylis glomerata; Quarter Horse; almond hulls; beets; blood glucose; blood serum; body weight; diet; feeds; functional properties; geldings; glucose; glycemic effect; hay; humans; ingredients; insulin; metabolism; oats; physiological response; soluble fiber; starch; sugar beet pulp
- Abstract:
- ... In humans, the consumption of soluble fibers reduces glycemic response after a meal. We hypothesized high soluble fiber diets would reduce and delay postprandial glucose and insulin responses in horses. In a 4 × 4 Latin square design experiment, four Quarter Horse geldings were adapted to diets containing orchardgrass hay (ORCH) or ORCH with 1 of 3 treatment ingredients: molassed sugar beet pulp ( ...
- DOI:
- 10.1016/j.jevs.2020.102963
- https://doi.org/10.1016/j.jevs.2020.102963
- Author:
- Simon J. Reider; Simon Moosmang; Judith Tragust; Lovro Trgovec-Greif; Simon Tragust; Lorenz Perschy; Nicole Przysiecki; Sonja Sturm; Herbert Tilg; Hermann Stuppner; Thomas Rattei; Alexander R. Moschen
- Source:
- Nutrients 2020 v.12 no.5 pp. -
- ISSN:
- 2072-6643
- Subject:
- Bacteroides; Roseburia; Ruminococcus; acetates; amino acids; blood serum; butyrates; clinical trials; feces; frequency; functional properties; germ-free animals; guar gum; humans; intestinal microorganisms; males; metabolites; metagenomics; models; nuclear magnetic resonance spectroscopy; nutrients; prebiotics; soluble fiber
- Abstract:
- ... (1) Background: Alterations in the structural composition of the human gut microbiota have been identified in various disease entities along with exciting mechanistic clues by reductionist gnotobiotic modeling. Improving health by beneficially modulating an altered microbiota is a promising treatment approach. Prebiotics, substrates selectively used by host microorganisms conferring a health benef ...
- DOI:
- 10.3390/nu12051257
- https://doi.org/10.3390/nu12051257
- Author:
- Satyamitra L. Shekh; Aarti A. Boricha; Jony G. Chavda; Bharatkumar Rajiv Manuel Vyas
- Source:
- Annals of microbiology 2020 v.70 no.1 pp. 16
- ISSN:
- 1590-4261
- Subject:
- Lactobacillus plantarum; biofilm; butyric acid; cells; cholesterol; choloylglycine hydrolase; digestive tract; enteropathogens; food spoilage; freeze drying; fructooligosaccharides; functional foods; functional properties; humans; intestines; inulin; lactulose; materials; methodology; mucins; prebiotics; probiotics; skim milk; storage; survival rate; viability
- Abstract:
- ... PURPOSE: Freeze drying of Lactobacillus plantarum GP in the presence of wall materials to achieve improved survival and retention of probiotic functionality during storage. METHODS: L. plantarum cells were lyophilized in the presence of inulin, fructooligosaccharides, lactulose, and/or skim milk. The lyophilized vials were stored at 8–10 °C up to 6 months and cells from these vials were evaluated ...
- DOI:
- 10.1186/s13213-020-01556-x
- https://doi.org/10.1186/s13213-020-01556-x
- Author:
- Bojie Fu
- Source:
- Geography and sustainability 2020 v.1 no.1 pp. 1-7
- ISSN:
- 2666-6839
- Subject:
- dynamics; ecosystem services; environment; functional properties; geography; humans; knowledge; methodology; models; objectives; research; social welfare; society; sustainability science and engineering; sustainable development
- Abstract:
- ... The discipline of geography encompasses both natural and social sciences and has the natural advantage of enabling the study of sustainability from a transdisciplinary perspective. There are great opportunities for geographers to participate in sustainability research. However, while geographers have set sustainability goals, they have rarely clarified the details for reaching those goals. Current ...
- DOI:
- 10.1016/j.geosus.2020.02.003
- https://doi.org/10.1016/j.geosus.2020.02.003
- Author:
- Lisa M. Smits; Stefano Magni; Kaoru Kinugawa; Kamil Grzyb; Joachim Luginbühl; Sonia Sabate-Soler; Silvia Bolognin; Jay W. Shin; Eiichiro Mori; Alexander Skupin; Jens C. Schwamborn
- Source:
- Cell and tissue research 2020 v.382 no.3 pp. 463-476
- ISSN:
- 0302-766X
- Subject:
- brain; dopamine; drugs; electrophysiology; functional properties; humans; image analysis; models; neurons; neurotransmitters; organoids; phenotype; research; sequence analysis; transcriptomics
- Abstract:
- ... Human stem cell-derived organoids have great potential for modelling physiological and pathological processes. They recapitulate in vitro the organization and function of a respective organ or part of an organ. Human midbrain organoids (hMOs) have been described to contain midbrain-specific dopaminergic neurons that release the neurotransmitter dopamine. However, the human midbrain contains also a ...
- DOI:
- 10.1007/s00441-020-03249-y
- https://doi.org/10.1007/s00441-020-03249-y
- Author:
- Ji Sun; Roderick MacKinnon
- Source:
- Cell 2020 v.180 no.2 pp. 340-347.e9
- ISSN:
- 0092-8674
- Subject:
- cryo-electron microscopy; electric potential difference; functional properties; gastric acid; glucose; heart; homeostasis; humans; lipids; potassium channels; secretion
- Abstract:
- ... KCNQ1, also known as Kv7.1, is a voltage-dependent K⁺ channel that regulates gastric acid secretion, salt and glucose homeostasis, and heart rhythm. Its functional properties are regulated in a tissue-specific manner through co-assembly with beta subunits KCNE1–5. In non-excitable cells, KCNQ1 forms a complex with KCNE3, which suppresses channel closure at negative membrane voltages that otherwise ...
- DOI:
- 10.1016/j.cell.2019.12.003
- PubMed:
- 31883792
- PubMed Central:
- PMC7083075
- https://doi.org/10.1016/j.cell.2019.12.003
- Author:
- Christina Gkolfinopoulou; Angeliki Bourtsala; Angeliki Chroni
- Source:
- Biochimica et biophysica acta 2020 v.1865 no.3 pp. 158593
- ISSN:
- 1388-1981
- Subject:
- apolipoprotein A-I; biogenesis; coronary artery disease; enzymes; functional properties; high density lipoprotein cholesterol; humans; phospholipids; point mutation; risk; thermodynamics
- Abstract:
- ... Several hereditary point mutations in human apolipoprotein A-I (apoA-I) have been associated with low HDL-cholesterol levels and/or increased coronary artery disease (CAD) risk. However, one apoA-I mutation, the V19L, recently identified in Icelanders, has been associated with increased HDL-cholesterol levels and decreased CAD risk. In an effort to gain mechanistic insight linking the presence of ...
- DOI:
- 10.1016/j.bbalip.2019.158593
- https://doi.org/10.1016/j.bbalip.2019.158593
- Author:
- Maryam Iftikhar; Asra Iftikhar; Huijuan Zhang; Lingxiao Gong; Jing Wang
- Source:
- Food research international 2020 v.136 pp. 109240
- ISSN:
- 0963-9969
- Subject:
- adverse effects; anti-inflammatory activity; antineoplastic activity; apoptosis; bioavailability; biotransformation; cell cycle checkpoints; cholesterol; drugs; functional foods; functional properties; humans; intestinal absorption; intestinal mucosa; mechanism of action; metabolism; molecular weight; neoplasm cells; oral administration; permeability; signal transduction; tight junctions
- Abstract:
- ... Caco-2, a human intestinal carcinoma cell line, has been used to test the absorption and transport mechanism of functional foods and drugs across the intestinal epithelium in order to study their antioxidant, anticancer and anti-inflammatory activities. Caco-2 cells represent the morphological and functional characteristics of small intestinal cells and capable of expressing brush borders, tight j ...
- DOI:
- 10.1016/j.foodres.2020.109240
- https://doi.org/10.1016/j.foodres.2020.109240
- Author:
- Ciarán McLaverty; Ole R. Eigaard; Henrik Gislason; Francois Bastardie; Mollie E. Brooks; Patrik Jonsson; Andreas Lehmann; Grete E. Dinesen
- Source:
- Ecological indicators 2020 v.110 pp. 105811
- ISSN:
- 1470-160X
- Subject:
- Nephrops norvegicus; benthic organisms; biomass; environmental factors; environmental indicators; fauna; fisheries management; fishery resources; functional diversity; functional properties; humans; population growth; salinity; sediments; temperature
- Abstract:
- ... Bottom trawling alters the abundance, diversity, size-composition, and function of benthic communities. However, the ability to detect these impacts over large spatial scales can be obscured by various complicating factors, such as community adaptation to disturbance and co-varying environmental conditions. An ecosystem-based approach to fisheries management therefore requires ecological indicator ...
- DOI:
- 10.1016/j.ecolind.2019.105811
- https://doi.org/10.1016/j.ecolind.2019.105811
- Author:
- Bengt-Olof Nilsson
- Source:
- Peptides 2020 v.128 pp. 170311
- ISSN:
- 0196-9781
- Subject:
- Gram-negative bacteria; Porphyromonas gingivalis; Streptococcus mutans; antimicrobial peptides; antimicrobial properties; blood plasma; cell viability; epithelial cells; functional properties; granulocyte colony-stimulating factor; humans; innate immunity; models; neutropenia; neutrophils; pathogens; patients; periodontal diseases; saliva
- Abstract:
- ... The human antimicrobial peptide LL-37 is produced by neutrophils and epithelial cells, and the peptide can be detected in plasma as well as saliva. LL-37 is active against both gram-positive and gram-negative bacteria including oral pathogens such as Porphyromonas gingivalis and Streptococcus mutans. Besides its antimicrobial properties, LL-37 modulates the innate immune system, and furthermore, i ...
- DOI:
- 10.1016/j.peptides.2020.170311
- https://doi.org/10.1016/j.peptides.2020.170311
- Author:
- Arleth S. López Rivero; Ma. Agustina Rossi; Eduardo A. Ceccarelli; Daniela L. Catalano-Dupuy
- Source:
- Biochimica et biophysica acta 2019 v.1863 no.4 pp. 651-660
- ISSN:
- 0304-4165
- Subject:
- Leptospira interrogans; bacteria; biochemical pathways; electrons; ferredoxin-NADP reductase; ferredoxins; functional properties; gene overexpression; genes; humans; mitochondria; models; mutagenesis; plastids
- Abstract:
- ... Ferredoxins are small iron-sulfur proteins that participate as electron donors in various metabolic pathways. They are recognized substrates of ferredoxin-NADP+ reductases (FNR) in redox metabolisms in mitochondria, plastids, and bacteria. We previously found a plastidic-type FNR in Leptospira interrogans (LepFNR), a parasitic bacterium of animals and humans. Nevertheless, we did not identify plan ...
- DOI:
- 10.1016/j.bbagen.2019.01.004
- https://doi.org/10.1016/j.bbagen.2019.01.004
- Author:
- Caroline J. Gallant; Ulf Landegren
- Source:
- FEBS journal 2019 v.286 no.8 pp. 1442-1444
- ISSN:
- 1742-464X
- Subject:
- functional properties; humans; medicine; research programs; therapeutics
- Abstract:
- ... Single‐cell analysis is impacting biology and medicine by changing the scale and resolution at which we investigate multicellular organisms. A particular, overarching aim of this field is to characterize the programmed development of all different cell types in the human body, as well as their individual spatial, molecular, and functional characteristics. This vast research program is generating a ...
- DOI:
- 10.1111/febs.14820
- https://doi.org/10.1111/febs.14820
- Author:
- Erwin Vera; Isabel Cornejo; Johanna Burgos; María Isabel Niemeyer; Francisco V. Sepúlveda; L. Pablo Cid
- Source:
- Biochemical and biophysical research communications 2019 v.514 no.3 pp. 574-579
- ISSN:
- 0006-291X
- Subject:
- choroid plexus; epithelium; functional properties; human cell lines; humans; kidneys; lungs; mice; mutation; permeability; plasma membrane; potassium channels; proteasome endopeptidase complex; retinal diseases; sodium-potassium-exchanging ATPase; vision
- Abstract:
- ... Kir7.1 is an inwardly rectifying K+ channel present in epithelia where it shares membrane localization with the Na+/K+-pump. In the present communication we report the presence of a novel splice variant of Kir7.1 in mouse tissues including kidney, lung, choroid plexus and retinal pigment epithelium (RPE). The variant named mKir7.1-SV2 lacks most of the C-terminus domain but is predicted to have th ...
- DOI:
- 10.1016/j.bbrc.2019.04.169
- https://doi.org/10.1016/j.bbrc.2019.04.169
- Author:
- Flávia Roberta Buss Marenda; Fernanda Mattioda; Ivo Mottin Demiate; Alicia de Francisco; Carmen Lúcia de Oliveira Petkowicz; Maria Helene Giovanetti Canteri; Renata Dias de Mello Castanho Amboni
- Source:
- Journal of polymers and the environment 2019 v.27 no.3 pp. 549-560
- ISSN:
- 1566-2543
- Subject:
- acetylation; analgesic effect; chemical structure; drug formulations; economic investment; esterification; foods; functional properties; galacturonic acid; humans; in vivo studies; industry; mechanism of action; molecular weight; pectins; raw materials; vegetable residues
- Abstract:
- ... Vegetable waste represents a serious environmental problem for industries; however, it is also a valuable source of pectic substances. This paper aims to highlight the advances that have been made through studies regarding pectic substances from vegetable wastes, as well as providing an overview of the chemical structure of pectin, extraction and characterisation techniques, and potential applicat ...
- DOI:
- 10.1007/s10924-018-1355-8
- https://doi.org/10.1007/s10924-018-1355-8
- Author:
- Katerina C. Nastou; Michail A. Batskinis; Zoi I. Litou; Stavros J. Hamodrakas; Vassiliki A. Iconomidou
- Source:
- Journal of proteome research 2019 v.18 no.5 pp. 2310-2320
- ISSN:
- 1535-3907
- Subject:
- amino acid sequences; arginine; cysteine; databases; electric potential difference; functional properties; genetic variation; glutamine; histidine; humans; ion channels; membrane potential; phenotype; proteome; single nucleotide polymorphism; statistical analysis; topology; transmembrane proteins
- Abstract:
- ... Voltage-gated ion channels (VGICs) are one of the largest groups of transmembrane proteins. Due to their major role in the generation and propagation of electrical signals, VGICs are considered important from a medical viewpoint, and their dysfunction is often associated with Channelopathies. We identified disease-associated mutations and polymorphisms in these proteins through mapping missense si ...
- DOI:
- 10.1021/acs.jproteome.9b00121
- https://doi.org/10.1021/acs.jproteome.9b00121
- Author:
- Zhen-Hui Cao; Julia M. Green-Johnson; Nicole D. Buckley; Qiu-Ye Lin
- Source:
- Biotechnology advances 2019 v.37 no.1 pp. 223-238
- ISSN:
- 0734-9750
- Subject:
- animal models; bioactive compounds; consumer demand; diet; fermentation; flavor; functional properties; guidelines; humans; lifestyle; medical history; metabolites; microbial communities; microbiome; microorganisms; natto; nutritive value; soy sauce; soymilk; tempeh; toxicity; Asia
- Abstract:
- ... For centuries, fermented soy foods have been dietary staples in Asia and, now, in response to consumer demand, they are available throughout the world. Fermentation bestows unique flavors, boosts nutritional values and increases or adds new functional properties. In this review, we describe the functional properties and underlying action mechanisms of soy-based fermented foods such as Natto, ferme ...
- DOI:
- 10.1016/j.biotechadv.2018.12.001
- https://doi.org/10.1016/j.biotechadv.2018.12.001
- Author:
- R.M. Botelho; L.P.G. Tenorio; A.L.M. Silva; E.L.L. Tanabe; K.S.N. Pires; C.M. Gonçalves; J.C. Santos; A.L.X. Marques; M.J. Allard; J.D. Bergeron; G. Sebire; E.C.O. Silva; S.T. Souza; E.J.S. Fonseca; A.U. Borbely; K.S.C. Borbely
- Source:
- Biochimica et biophysica acta 2019 v.1863 no.9 pp. 1417-1428
- ISSN:
- 0304-4165
- Subject:
- Streptococcus agalactiae; atomic force microscopy; bacteria; biomechanics; cell death; cell viability; cytoskeleton; death; diet; fluorescent antibody technique; functional properties; humans; inflammation; interferon-gamma; interleukin-1beta; interleukin-2; interleukin-4; nitrites; olive oil; pregnancy; pregnant women; secretion; triterpenoids; trophoblast
- Abstract:
- ... Group B streptococcus (GBS) is the main bacteria that infects pregnant women and can cause abortion and chorioamnionitis. The impact of GBS effects on human trophoblast cells remains largely elusive, and actions toward anti-inflammatory strategies in pregnancy are needed. A potent anti-inflammatory molecule, uvaol is a triterpene from olive oil and its functions in trophoblasts are unknown. We aim ...
- DOI:
- 10.1016/j.bbagen.2019.06.012
- https://doi.org/10.1016/j.bbagen.2019.06.012
- Author:
- Roberto Portillo-Lara; Andrew R. Spencer; Brian W. Walker; Ehsan Shirzaei Sani; Nasim Annabi
- Source:
- Biomaterials 2019 v.198 pp. 78-94
- ISSN:
- 0142-9612
- Subject:
- biocompatible materials; biofabrication; biomimetics; cardiovascular diseases; cell engineering; diagnostic techniques; drugs; functional properties; genetic engineering; health services; humans; industry; microfluidic technology; mortality; myocardium; organ-on-a-chip; patients; screening; stem cells; therapeutics; tissue engineering
- Abstract:
- ... Bioengineered tissues have become increasingly more sophisticated owing to recent advancements in the fields of biomaterials, microfabrication, microfluidics, genetic engineering, and stem cell and developmental biology. In the coming years, the ability to engineer artificial constructs that accurately mimic the compositional, architectural, and functional properties of human tissues, will profoun ...
- DOI:
- 10.1016/j.biomaterials.2018.08.010
- https://doi.org/10.1016/j.biomaterials.2018.08.010
- Author:
- Neethu Puthumadathil; Poornendhu Jayasree; K. Santhosh Kumar; K. Madhavan Nampoothiri; Harsha Bajaj; Kozhinjampara R. Mahendran
- Source:
- Biomaterials science 2019 v.7 no.8 pp. 3226-3237
- ISSN:
- 2047-4849
- Subject:
- antimicrobial peptides; detergents; functional properties; humans; lipid bilayers; mechanism of action; micelles; molecular models; permeability; sodium dodecyl sulfate; therapeutics
- Abstract:
- ... The pore-forming structures of an anionic human antimicrobial peptide dermcidin (DCD) in a membrane environment has not been demonstrated previously. Using single-channel electrical recordings, we characterized the structural and functional properties of the DCD peptide channel in lipid membranes. We show that a 48-residue, 8 nm long anionic DCD-1L peptide is folded in the right conformation in so ...
- DOI:
- 10.1039/c9bm00181f
- https://doi.org/10.1039/c9bm00181f
- Author:
- Francesca Zanoni; Martina Vakarelova; Gianni Zoccatelli
- Source:
- Marine drugs 2019 v.17 no.11 pp. -
- ISSN:
- 1660-3397
- Subject:
- Haematococcus pluvialis; astaxanthin; bioavailability; digestion; encapsulation; evaporation; functional properties; humans; iron; microalgae; nanocapsules; nanoparticles; oxidation; pH; particle size; stabilizers; ultraviolet radiation; whey; whey protein; zeta potential
- Abstract:
- ... Astaxanthin (ASX) is a carotenoid of great interest due to its potential health benefits. However, its use in the food, feed, and pharmaceutical fields is limited due to low bioavailability, poor stability during thermochemical treatments, susceptibility to oxidation, and poor organoleptic characteristics. The aim of this work was to develop a method to stabilize astaxanthin extracted from the mic ...
- DOI:
- 10.3390/md17110627
- PubMed:
- 31689914
- PubMed Central:
- PMC6891650
- https://doi.org/10.3390/md17110627
- Author:
- Scott S. Graves; Boglarka Gyurkocza; Diane M. Stone; Maura H. Parker; Kraig Abrams; Christoph Jochum; Susanna Gallo; Marium Saad; Melissa M. Johnson; Steven L. Rosinski; Rainer Storb
- Source:
- Veterinary immunology and immunopathology 2019 v.211 pp. 10-18
- ISSN:
- 0165-2427
- Subject:
- cell lines; cytotoxicity; dogs; functional properties; granules; humans; innate immunity; interleukin-15; interleukin-2; mice; monoclonal antibodies; natural killer cells; transmission electron microscopy
- Abstract:
- ... Natural killer (NK) cells are non-T, non-B lymphocytes are part of the innate immune system and function without prior activation. The human NK cell surface determinant, CD94, plays a critical role in regulation of NK cell activity as a heterodimer with NKG2 subclasses. Canine NK cells are not as well defined as the human and murine equivalents, due in part to the paucity of reagents specific to c ...
- DOI:
- 10.1016/j.vetimm.2019.03.005
- PubMed:
- 31084888
- PubMed Central:
- PMC7048049
- https://doi.org/10.1016/j.vetimm.2019.03.005
- Author:
- Panagiotis G. Adamopoulos; Christos K. Kontos; Andreas Scorilas
- Source:
- Genomics 2019 v.111 no.4 pp. 642-652
- ISSN:
- 0888-7543
- Subject:
- alternative splicing; bioinformatics; biomarkers; functional properties; genes; high-throughput nucleotide sequencing; humans; neoplasm cells; neoplasms; plasma kallikrein; polymerase chain reaction; tissue kallikrein
- Abstract:
- ... Tissue kallikrein, kallikrein-related peptidases (KLKs), and plasma kallikrein form the largest group of serine proteases in the human genome, sharing many structural and functional properties. Several KLK transcripts have been found aberrantly expressed in numerous human malignancies, confirming their prognostic or/and diagnostic values. However, the process of alternative splicing can now be stu ...
- DOI:
- 10.1016/j.ygeno.2018.03.022
- https://doi.org/10.1016/j.ygeno.2018.03.022
- Author:
- Chao Zhao; Yuanyuan Liu; Shanshan Lai; Hui Cao; Yi Guan; Wai San Cheang; Bin Liu; Kewei Zhao; Song Miao; Céline Riviere; Esra Capanoglu; Jianbo Xiao
- Source:
- Trends in food science & technology 2019 v.85 pp. 55-66
- ISSN:
- 0924-2244
- Subject:
- antineoplastic activity; antioxidant activity; ascorbic acid; bioavailability; carotenoids; chlorophyll; cooking; crude fat; dietary fiber; dietary supplements; digestibility; flavonols; foods; functional properties; glucosinolates; humans; minerals; nutrients; nutritive value; palatability; polyphenols
- Abstract:
- ... Foods are good sources of vitamins, minerals and dietary fibers as well as phytochemicals, which are beneficial for the human body as nutritional supplements. The nutritional value (crude fibers, crude proteins, crude fats, flavonols, carotenoids, polyphenols, glucosinolate, chlorophyll, and ascorbic acid) and biological or functional properties (antioxidant activity, anticancer activity, or anti- ...
- DOI:
- 10.1016/j.tifs.2019.01.004
- https://doi.org/10.1016/j.tifs.2019.01.004
- Author:
- Diego Fernandes Gomes Pereira; José Max Barbosa de Oliveira Junior; Leandro Juen
- Source:
- Ecological indicators 2019 v.98 pp. 179-192
- ISSN:
- 1470-160X
- Subject:
- Libellulidae; Zygoptera; abdomen; adults; biodiversity; ecophysiology; endophytes; environmental factors; environmental indicators; extinction; functional properties; habitats; humans; livestock; macrophytes; oviposition; plantations; streams; thermoregulation; thorax; Amazonia
- Abstract:
- ... Species occurrence can be affected by the availability of environments that fit within the limits of variation of its niche and by interaction with other species. Modifications in the environment, especially those caused by mankind, are considered the leading cause for species extinction. Such a response from the species is not random, with patterns that can follow functionality and/or morphology ...
- DOI:
- 10.1016/j.ecolind.2018.09.020
- https://doi.org/10.1016/j.ecolind.2018.09.020
- Author:
- Shirin Ferdowsi; Ali Akbar Pourfathollah; Fatemeh Amiri; Mohammad Hessam Rafiee; Afsaneh Aghaei
- Source:
- Life sciences 2019 v.224 pp. 249-254
- ISSN:
- 0024-3205
- Subject:
- T-lymphocytes; Western blotting; antineoplastic activity; apoptosis; blood banks; caspase-3; cell viability; cytoplasmic granules; disulfide bonds; drug therapy; drugs; filters; fluorescence; functional properties; humans; neutrophils; peptides
- Abstract:
- ... The α-defensins or human neutrophil peptides (HNP 1–3) that exist in azurophilic granules are found to have anticancer activity. The pattern of disulfide bonds in α-defensins is crucial for the functional properties. Therefore, synthesis using the chemical and recombinant approaches is a challenging. A safe source for the production of α-defensins can be the use of leukoreduction filters in blood ...
- DOI:
- 10.1016/j.lfs.2019.03.072
- https://doi.org/10.1016/j.lfs.2019.03.072
- Author:
- Wei Yuen Yap; Katrina Joan Shu Xian Tan; Jung Shan Hwang
- Source:
- Toxicon 2019 v.170 pp. 10-20
- ISSN:
- 0041-0101
- Subject:
- Hydra vulgaris; data collection; endoderm; females; functional properties; gene duplication; gene expression; genes; germ cells; hemolysis; humans; mutants; oogenesis; recombinant proteins; sequence analysis; sphingolipids; toxicity
- Abstract:
- ... Hydra actinoporin-like toxin 1 (HALT-1) was previously shown to cause cytolysis and haemolysis in a number of human cells and has similar functional properties to the actinoporins equinatoxin and sticholysin. In addition to HALT-1, five other HALTs (HALTs 2, 3, 4, 6 and 7) were also isolated from Hydra magnipapillata and expressed as recombinant proteins in this study. We demonstrated that recombi ...
- DOI:
- 10.1016/j.toxicon.2019.09.007
- https://doi.org/10.1016/j.toxicon.2019.09.007
- Author:
- Prejit; Prakasam Thanka Pratheesh; Soman Nimisha; Vergis Jess; Karthikeyan Asha; Rajesh Kumar Agarwal
- Source:
- Biologicals 2019 v.62 pp. 22-26
- ISSN:
- 1045-1056
- Subject:
- Escherichia coli; Salmonella Typhimurium; Western blotting; foodborne illness; functional properties; genes; humans; inclusion bodies; molecular weight; nickel; nitrilotriacetic acid; outer membrane proteins; pathogens; polyacrylamide gel electrophoresis; poultry; poultry diseases; poultry products; protein synthesis; recombinant vaccines; rhamnose; salmonellosis
- Abstract:
- ... Salmonella is found to be a major causes of food borne diseases globally. Poultry products contaminated with this pathogen is one of the major sources of infections in humans. Outer membrane protein C (OmpC) of Salmonella Typhimurium is a promising DNA vaccine candidate to mitigate Salmonella infection in poultry. However, the large-scale production of bioactive recombinant OmpC (rOmpC) protein is ...
- DOI:
- 10.1016/j.biologicals.2019.10.010
- https://doi.org/10.1016/j.biologicals.2019.10.010