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You searched for: Subject term humans Remove constraint Subject term: humans Subject term infectious diseases Remove constraint Subject term: infectious diseases
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1. An AGC kinase, PgAGC1 regulates virulence in the entomopathogenic oomycete Pythium guiyangense

Author:
Cong Wang; Danyu Shen; Jing Wang; Yang Chen; Yumei Dong; Zhaoyang Tang; Ai Xia
Source:
Fungal biology 2019 v.123 no.1 pp. 87-93
ISSN:
1878-6146
Subject:
Aedes albopictus; Culex pipiens pallens; Pythium; biological control agents; chemical compounds; enzymes; gene expression regulation; genes; genetic transformation; humans; infectious diseases; larvae; mortality; mosquito control; stress response; stress tolerance; transcription (genetics); vector control; virulence; China
Abstract:
... Mosquitoes are the most important medical species by transmitting some of deadly infectious diseases to human. In recent years extensive studies of vector control have been focused on biological control agents due to the grave issue raised by continuous application of chemical compounds. Pythium guiyangense X.Q. Su was first isolated from infected larvae of Aedes albopictus in 2006 in China and it ...
DOI:
10.1016/j.funbio.2018.11.006

2. AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases

Author:
José M. Arencibia; Daniel Pastor-Flores; Angelika F. Bauer; Jörg O. Schulze; Ricardo M. Biondi
Source:
BBA - Proteins and Proteomics 2013 v.1834 pp. 1302-1321
ISSN:
1570-9639
Subject:
cAMP-dependent protein kinase; cGMP-dependent protein kinase; diabetes; dimerization; drugs; eukaryotic cells; genome; human diseases; humans; infectious diseases; inflammation; nervous system diseases; obesity; phosphorylation; physiology; protein kinase C
Abstract:
... The group of AGC protein kinases includes more than 60 protein kinases in the human genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK, NDR, MAST, YANK, DMPK, GRK and SGK494. This group is also widely represented in other eukaryotes, including causative organisms of human infectious diseases. AGC kinases are involved in diverse cellular functions and are potential ...
DOI:
10.1016/j.bbapap.2013.03.010

3. The Absence of Zoonotic Agents in Invasive Bullfrogs (Lithobates catesbeianus) in Belgium and The Netherlands

Author:
An Martel; Connie Adriaensen; Mojdeh Sharifian-Fard; Annemarieke Spitzen-van der Sluijs; Gerald Louette; Kristof Baert; Ben Crombaghs; Jeroen Dewulf; Frank Pasmans
Source:
Ecohealth 2013 v.10 no.4 pp. 344-347
ISSN:
1612-9202
Subject:
Campylobacter; Coxiella burnetii; Escherichia coli; Leptospira; Lithobates catesbeianus; Mycoplasma; Neospora caninum; Ranavirus; Salmonella; Toxoplasma gondii; amphibians; beta-lactamase; genomics; humans; infectious diseases; invasive species; pathogens; predation; Belgium; Netherlands
Abstract:
... Exotic invasive bullfrogs (Lithobates catesbeianus) are considered to exert a considerable negative impact on native amphibian communities. This can be due to competition and predation, but they are also a notorious source of the infectious diseases chytridiomycosis and ranavirosis, affecting amphibian populations globally. Little is known regarding their carriage of other microbial agents that mi ...
DOI:
10.1007/s10393-013-0864-0
PubMed:
24162797

4. Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA

Author:
Lanford, Robert E.; Feng, Zongdi; Chavez, Deborah; Guerra, Bernadette; Brasky, Kathleen M.; Zhou, Yan; Yamane, Daisuke; Perelson, Alan S.; Walker, Christopher M.; Lemon, Stanley M.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.27 pp. 11223-11228
ISSN:
0027-8424
Subject:
viremia; genes; interferons; infectious diseases; Hepatitis C virus; antibodies; feces; gene expression; pathogenesis; apoptosis; Flavivirus; Pan troglodytes; acute course; blood serum; humans; chronic diseases; hepatocytes; liver; innate immunity; host-pathogen relationships; Hepatovirus A; inflammation; reverse transcriptase polymerase chain reaction; animal models; RNA
Abstract:
... Hepatitis A virus (HAV) is an hepatotropic human picornavirus that is associated only with acute infection. Its pathogenesis is not well understood because there are few studies in animal models using modern methodologies. We characterized HAV infections in three chimpanzees, quantifying viral RNA by quantitative RT-PCR and examining critical aspects of the innate immune response including intrahe ...
DOI:
10.1073/pnas.1101939108
PubMed:
21690403
PubMed Central:
PMC3131353

5. The Adenylate Cyclase Toxins

Author:
Nidhi Ahuja; Praveen Kumar; Rakesh Bhatnagar
Source:
Critical reviews in microbiology 2004 v.30 no.3 pp. 187-196
ISSN:
1549-7828
Subject:
Bacillus anthracis; Bordetella pertussis; Pseudomonas aeruginosa; Yersinia pestis; adenylate cyclase; anthrax toxin; bacteria; calmodulin; cyclic AMP; humans; immune system; infectious diseases; pathogenesis; virulent strains
Abstract:
... Cyclic AMP is a ubiquitous messenger that integrates many processes of the cell. Diverse families of adenylate cyclases and phosphodiesterases stringently regulate the intracellular concentration of cAMP. Any alteration in the cytosolic concentration of cAMP has a profound effect on the various processes of the cell. Disruption of these cellular processes in vivo is often the most critical event i ...
DOI:
10.1080/10408410490468795

6. Adjuvant effects of TLR agonist gardiquimod admixed with Leishmania vaccine in mice model of visceral leishmaniasis

Author:
Deepak Kumar Goyal; Poonam Keshav; Sukhbir Kaur
Source:
Infection, genetics, and evolution 2021 v.93 pp. 104947
ISSN:
1567-1348
Subject:
Phlebotomus; adjuvants; agonists; antigens; cell-mediated immunity; cytokines; delayed hypersensitivity; drug therapy; evolution; genetics; humans; immunoglobulin G; infection; infectious diseases; macrophages; nitric oxide; parasite load; parasites; promastigotes; tropical diseases; vaccination; vaccines; visceral leishmaniasis
Abstract:
... Tropical and subtropical areas of the world are affected by leishmaniasis, which is caused by Leishmania spp. It has been categorized as an NTD (neglected tropical disease) because of its negligence. The sand fly of genus Phlebotomus acts as the vector for the transmission of the promastigote form of this protozoan parasite to the mammalian host where it converts to amastigote form in the macropha ...
DOI:
10.1016/j.meegid.2021.104947

7. Advances in Molecular Tools and In Vivo Models for the Study of Human Fungal Pathogenesis

Author:
Dhara Malavia; Neil A. R. Gow; Jane Usher
Source:
Microorganisms 2020 v.8 no.6 pp. -
ISSN:
2076-2607
Subject:
Danio rerio; Galleria mellonella; RNA interference; animal models; antifungal agents; drug resistance; fungi; humans; infectious diseases; pathogenesis; pathogenicity; silkworms; site-directed mutagenesis; transposons
Abstract:
... Pathogenic fungi represent an increasing infectious disease threat to humans, especially with an increasing challenge of antifungal drug resistance. Over the decades, numerous tools have been developed to expedite the study of pathogenicity, initiation of disease, drug resistance and host-pathogen interactions. In this review, we highlight advances that have been made in the use of molecular tools ...
DOI:
10.3390/microorganisms8060803

8. Advances in equine immunology: Havemeyer workshop reports from Santa Fe, New Mexico, and Hortobagy, Hungary

Author:
Marti, Eliane; Horohov, David W.; Antzak, Doug F.; Lazary, Sandor; Lunn, D. Paul
Source:
Veterinary immunology and immunopathology 2003 v.91 no.3-4 pp. 233-243
ISSN:
0165-2427
Subject:
horses; humans; immunology; infectious diseases; Hungary; New Mexico
Abstract:
... The horse has been human kind’s most important partner throughout history. Similarly, in the field of immunology, many critical scientific advances have depended on the horse. Equine immunology today is an active and important field of study, with a focus on control of many common infectious diseases and immunopathologic conditions of broad comparative interest. In 2001 two major equine immunology ...
DOI:
10.1016/S0165-2427(02)00314-8

9. Aflatoxin Exposure in Developing Countries: The Critical Interface of Agriculture and Health

Author:
Christopher Paul Wild
Source:
Food and nutrition bulletin v.28 no.2_suppl2 pp. S372
ISSN:
0379-5721
Subject:
Hepatitis B virus; aflatoxins; animal diseases; carcinogens; children; developing countries; farmed animal species; growth retardation; human population; humans; immunity; infectious diseases; liver; public health; staple foods; Western Africa
Abstract:
... Aflatoxins are common contaminants of staple foods in sub-Saharan Africa. These toxins are human liver carcinogens, especially in combination with chronic infection with hepatitis B virus. However, in an agricultural setting, the effects on growth, immune status, and susceptibility to infectious disease in farm animals are also well recognized. These latter effects have been far less explored in h ...
DOI:
10.1177/15648265070282S217

10. African schistosomiasis in mainland China: risk of transmission and countermeasures to tackle the risk

Author:
Wei Wang; You-Sheng Liang; Qing-Biao Hong; Jian-Rong Dai
Source:
Parasites & vectors 2013 v.6 no.1 pp. 249
ISSN:
1756-3305
Subject:
Biomphalaria straminea; Schistosoma japonicum; Schistosoma mansoni; climate change; disease control; exports; habitats; humans; infectious diseases; intermediate hosts; labor; public health; risk; schistosomiasis; snails; subtropics; tropics; Africa; China; South America
Abstract:
... Schistosomiasis is a major disease of public health importance in humans occurring in 76 countries of the tropics and sub-tropics. In China, schistosomiasis japonica is one of the highest priorities in communicable disease control defined by the central government. Since 1970s, the habitats of Biomphalaria straminea, an intermediate host of Schistosoma mansoni in South America, have been identifie ...
DOI:
10.1186/1756-3305-6-249
PubMed:
23985040
PubMed Central:
PMC3765897

11. Agro-defense: Biosensors for food from healthy crops and animals

Author:
Suresh Neethirajan; K.V. Ragavan; Xuan Weng
Source:
Trends in food science & technology 2018 v.73 pp. 25-44
ISSN:
0924-2244
Subject:
animal health; bacteria; biodiversity; biosensors; crops; death; food chain; food production; fungi; humans; infectious diseases; metabolism; microbial detection; nanomaterials; pathogens; point-of-care systems; viruses
Abstract:
... Infectious diseases are a leading cause of death in humans, animals, and plants globally. Pathogen infections can reduce food production and endanger biodiversity. Viruses, bacteria, and fungi are therefore scientifically and economically important in food production. Even outbreaks of a pathogen infection in plants or animals have direct consequences for the food chain and human health.Microorgan ...
DOI:
10.1016/j.tifs.2017.12.005

12. Aleutian Disease:An Emerging Disease in Free-Ranging Striped Skunks (Mephitis mephitis) From California

Author:
E. E. B. LaDouceur; M. Anderson; B. W. Ritchie; P. Ciembor; G. Rimoldi; M. Piazza; D. Pesti; D. L. Clifford; F. Giannitti
Source:
Veterinary pathology v.52 no.6 pp. 1250-1253
ISSN:
1544-2217
Subject:
animal pathology; hepatitis; arteritis; necrosis; skunks; ferrets; encephalomalacia; heart; Carnivore amdoparvovirus 1; glomerulonephritis; brain; pneumonia; mink; spleen; carnivores; in situ hybridization; humans; ascites; polymerase chain reaction; kidneys; splenomegaly; fur-bearing animals; myocarditis; microangiopathy; emerging diseases; inflammation; Aleutian mink disease; meningoencephalitis; California
Abstract:
... Aleutian disease virus (ADV, Amdovirus, Parvoviridae) primarily infects farmed mustelids (mink and ferrets) but also other fur-bearing animals and humans. Three Aleutian disease (AD) cases have been described in captive striped skunks; however, little is known about the relevance of AD in free-ranging carnivores. This work describes the pathological findings and temporospatial distribution in 7 ca ...
DOI:
10.1177/0300985814560234

13. Alteration of host-pathogen interactions in the wake of climate change – Increasing risk for shellfish associated infections?

Author:
Bodil E. Hernroth; Susanne P. Baden
Source:
Environmental research 2018 v.161 pp. 425-438
ISSN:
0013-9351
Subject:
Vibrio; antimicrobial properties; climate; climate change; coastal water; enteropathogens; host-pathogen relationships; humans; hypoxia; immune response; immune system; infectious diseases; manganese; ocean acidification; risk; runoff; seafoods; shellfish; surface water temperature; synergism
Abstract:
... The potential for climate-related spread of infectious diseases through marine systems has been highlighted in several reports. With this review we want to draw attention to less recognized mechanisms behind vector-borne transmission pathways to humans. We have focused on how the immune systems of edible marine shellfish, the blue mussels and Norway lobsters, are affected by climate related enviro ...
DOI:
10.1016/j.envres.2017.11.032

14. Alternative splicing of the trout Pax5 gene and identification of novel B cell populations using Pax5 signatures

Author:
Elizabeth MacMurray; Maggie Barr; Amber Bruce; Lidia Epp; Patty Zwollo
Source:
Developmental and comparative immunology 2013 v.41 no.2 pp. 270-281
ISSN:
0145-305X
Subject:
transcription factors; infectious diseases; alternative splicing; humans; biomarkers; antibodies; Oncorhynchus mykiss; flow cytometry; spleen; disease resistance; exons; population; trout; blood; tissues
Abstract:
... Pax5 is an alternatively spliced transcription factor that regulates B cell development and activation. The function of specific Pax5 isoforms is unknown. Here we report the existence of seven alternatively spliced isoforms of Pax5 in the rainbow trout. We hypothesized that B cells differentially express specific Pax5 isoforms as a means of modulating Pax5 activity during cell maturation. Flow cyt ...
DOI:
10.1016/j.dci.2013.06.008
PubMed:
23796789
PubMed Central:
PMC3932526

15. Aluminum hydroxide colloid vaccine encapsulated in yeast shells with enhanced humoral and cellular immune responses

Author:
Hui Liu; Zhenghu Jia; Chengmao Yang; Mei Song; Zhe Jing; Yapu Zhao; Zhenzhou Wu; Liqing Zhao; Dongsheng Wei; Zhinan Yin; Zhangyong Hong
Source:
Biomaterials 2018 v.167 pp. 32-43
ISSN:
0142-9612
Subject:
adjuvants; alum; aluminum hydroxide; animal models; antibodies; antigens; beta-glucans; cell-mediated immunity; colloids; cytokines; dendritic cells; humans; humoral immunity; immune response; infectious diseases; mixing; neoplasms; proteins; secretion; vaccination; vaccines; yeasts
Abstract:
... Aluminum salt (Alum) is one of the most important immune adjuvants approved for use in humans, however it is not suitable for vaccination against various chronic infectious diseases and cancers for not being able to induce cell-mediated (Th1) immunity. Here, we encapsulated an Alum colloid inside β-glucan particles (GPs), which are a type of natural particles derived from the yeast glucan shells, ...
DOI:
10.1016/j.biomaterials.2018.03.014

16. Ambient bioaerosol distribution and associated health risks at a high traffic density junction at Dehradun city, India

Author:
Sandeep Madhwal; Vignesh Prabhu; Sangeeta Sundriyal; Vijay Shridhar
Source:
Environmental monitoring and assessment 2020 v.192 no.3 pp. 196
ISSN:
0167-6369
Subject:
Aspergillus; Bacillus (bacteria); Cladosporium; Micrococcus; Penicillium; Staphylococcus; bacteria; bioaerosols; disease transmission; emissions; fungi; health effects assessments; humans; infectious diseases; meteorological parameters; monsoon season; particulates; pathogens; respiratory tract diseases; roadside soils; spectrometers; statistical analysis; traffic; India
Abstract:
... Traffic junctions are one of the crowded places where commuters are at high risk of developing respiratory infections, due to their greater exposure to airborne and human transmitted microbial pathogens. An airborne bioaerosol assessment study was carried out at a high traffic density junction focusing on their concentration, contribution in respirable particulate matter (PM), and factors influenc ...
DOI:
10.1007/s10661-020-8158-9
PubMed:
32086610
PubMed Central:
PMC7087893

17. American Trypanosomiasis Infection in Fattening Pigs from the South‐East of Mexico

Author:
M. Jiménez‐Coello; K. Y. Acosta‐Viana; E. Guzman‐Marin; A. Ortega‐Pacheco
Source:
Zoonoses and public health 2012 v.59 Suppl s2 no. pp. 166-169
ISSN:
1863-1959
Subject:
Chagas disease; Trypanosoma cruzi; Western blotting; animal parasites and pests; antibodies; blood transfusion; cats; dogs; enzyme-linked immunosorbent assay; farm area; farm size; finishing; hosts; humans; immunoglobulin G; infectious diseases; ingestion; opossums; organ transplantation; parasites; production technology; rats; swine; Mexico; United States
Abstract:
... American Trypanosomiasis (AT) is an infectious parasitic disease produced by the protozoa Trypanosoma cruzi (T. cruzi). Infection is acquired by vectorial via but can also be transmitted congenitally, by ingestion of an infected host, by transfusion with contaminated blood or transplant of organs from an infected donor. Currently, AT is widely distributed from the South of the United States to Sou ...
DOI:
10.1111/zph.12016
PubMed:
22958261

18. Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia

Author:
Jyoti Chhibber-Goel; Sarthak Joshi; Amit Sharma
Source:
Parasites & vectors 2019 v.12 no.1 pp. 482
ISSN:
1756-3305
Subject:
Babesia bigemina; Babesia bovis; Babesia microti; Homo sapiens; Internet; Ixodes scapularis; Panthera leo; Panthera pardus; Panthera tigris; Protozoa; Rhipicephalus microplus; aminoacyl tRNA ligases; aminoacyl transfer RNA; babesiosis; cattle; disease vectors; drugs; genome; horses; humans; infectious diseases; pathogens; sequence analysis; ticks
Abstract:
... BACKGROUND: A century ago, pantheras were abundant across Asia. Illegal hunting and trading along with loss of habitat have resulted in the designation of Panthera as a genus of endangered species. In addition to the onslaught from humans, pantheras are also susceptible to outbreaks of several infectious diseases, including babesiosis. The latter is a hemoprotozoan disease whose causative agents a ...
DOI:
10.1186/s13071-019-3717-z
PubMed:
31610802
PubMed Central:
PMC6792207

19. Anaemia, hypothyroidism and immune suppression associated with polychlorinated biphenyl exposure in bottlenose dolphins (Tursiops truncatus)

Author:
Lori H. Schwacke; Eric S. Zolman; Brian C. Balmer; Sylvain De Guise; R. Clay George; Jennifer Hoguet; Aleta A. Hohn; John R. Kucklick; Steve Lamb; Milton Levin; Jenny A. Litz; Wayne E. McFee; Ned J. Place; Forrest I. Townsend; Randall S. Wells; Teresa K. Rowles
Source:
Proceedings 2012 v.279 no.1726 pp. 48-57
ISSN:
0962-8452
Subject:
DDT (pesticide); Tursiops truncatus; anemia; blubber; correlation; dolphins; endocrine system; fish; humans; hypothyroidism; infectious diseases; innate immunity; polychlorinated biphenyls; predators; toxicity; triiodothyronine; whales; Georgia
Abstract:
... Polychlorinated biphenyls (PCBs), persistent chemicals widely used for industrial purposes, have been banned in most parts of the world for decades. Owing to their bioaccumulative nature, PCBs are still found in high concentrations in marine mammals, particularly those that occupy upper trophic positions. While PCB-related health effects have been well-documented in some mammals, studies among dol ...
DOI:
10.1098/rspb.2011.0665
PubMed:
21613298
PubMed Central:
PMC3223648

20. Analysis of protein targets in pathogen–host interaction in infectious diseases: a case study on Plasmodium falciparum and Homo sapiens interaction network

Author:
Sovan Saha; Kaustav Sengupta; Piyali Chatterjee; Subhadip Basu; Mita Nasipuri
Source:
Briefings in functional genomics 2017 v.17 no.6 pp. 441-450
ISSN:
2041-2657
Subject:
Plasmodium falciparum; case studies; disease progression; drugs; gene ontology; genomics; host-pathogen relationships; humans; infectious diseases; malaria; pathogens
Abstract:
... Infection and disease progression is the outcome of protein interactions between pathogen and host. Pathogen, the role player of Infection, is becoming a severe threat to life as because of its adaptability toward drugs and evolutionary dynamism in nature. Identifying protein targets by analyzing protein interactions between host and pathogen is the key point. Proteins with higher degree and posse ...
DOI:
10.1093/bfgp/elx024

21. Analytical validation of a lymphocytic choriomeningitis virus real-time RT-PCR assay

Author:
Samuel Cordey; Roland Sahli; Marie-Laurence Moraz; Christine Estrade; Laurence Morandi; Pascal Cherpillod; Remi N. Charrel; Stefan Kunz; Laurent Kaiser
Source:
Journal of virological methods 2011 v.177 no.1 pp. 118-122
ISSN:
0166-0934
Subject:
etiology; central nervous system; detection limit; acute course; infectious diseases; complementary DNA; humans; hospitals; meningitis; nucleoproteins; reverse transcriptase polymerase chain reaction; cerebrospinal fluid; plasmids; Lymphocytic choriomeningitis mammarenavirus; nucleotide sequences; patients; screening; Switzerland
Abstract:
... Lymphocytic choriomeningitis virus (LCMV) is a rare cause of central nervous system disease in humans. Screening by real-time RT-PCR assay is of interest in the case of aseptic meningitis of unknown etiology. A specific LCMV real-time RT-PCR assay, based on the detection of genomic sequences of the viral nucleoprotein (NP), was developed to assess the presence of LCMV in cerebrospinal fluids (CSF) ...
DOI:
10.1016/j.jviromet.2011.06.018

22. Animal Migration and Infectious Disease Risk

Author:
Altizer, Sonia; Bartel, Rebecca; Han, Barbara A.
Source:
Science 2011 v.331 no.6015 pp. 296-302
ISSN:
0036-8075
Subject:
global change; habitats; hosts; humans; immune response; infectious diseases; migratory behavior; migratory species; mortality; pathogens; risk; wildlife
Abstract:
... Animal migrations are often spectacular, and migratory species harbor zoonotic pathogens of importance to humans. Animal migrations are expected to enhance the global spread of pathogens and facilitate cross-species transmission. This does happen, but new research has also shown that migration allows hosts to escape from infected habitats, reduces disease levels when infected animals do not migrat ...
DOI:
10.1126/science.1194694

23. Anionic phospholipid expression as a molecular target in Listeria monocytogenes and Escherichia coli

Author:
Patrick McKernan; Benjamin Cassidy; Alexis Woodward; James Battiste; Douglas Drevets; Roger Harrison
Source:
International journal of antimicrobial agents 2020 v.56 no.6 pp. 106183
ISSN:
0924-8579
Subject:
Escherichia coli; Gram-negative bacteria; Gram-positive bacteria; Listeria monocytogenes; ampicillin; antibacterial properties; carcinogenesis; drug therapy; endothelial cells; humans; infectious diseases; moxifloxacin; parasitoses; phospholipids; toxicity
Abstract:
... This study validates bacterial anionic phospholipids (APs) as a putative molecular target in a novel antibiotic treatment against the Gram-positive bacterium Listeria monocytogenes and the Gram-negative bacterium Escherichia coli. Bacterial AP expression was targeted with its associated protein-ligand partner, annexin A5 (ANXA5). This protein was functionalised with the covalent addition of the an ...
DOI:
10.1016/j.ijantimicag.2020.106183

24. Antagonistic activity of recombinant Lactococcus lactis NZ1330 on the adhesion properties of Escherichia coli causing urinary tract infection

Author:
Alireza Vasiee; Seyed Ali Mortazavi; Mojtaba Sankian; Farideh Tabatabaee Yazdi; Mahmoud Mahmoudi; Fakhri Shahidi
Source:
Microbial pathogenesis 2019 v.133 pp. 103547
ISSN:
0882-4010
Subject:
Escherichia coli; Lactococcus lactis; adenocarcinoma; allergens; bacterial adhesion; bile resistance; bile salts; death; gene expression; genes; humans; hydrophobicity; infectious diseases; intestines; medicine; pH; pathogens; probiotics; scanning electron microscopy; therapeutics; urinary tract diseases
Abstract:
... Death from infectious diseases has caused concerns about increases in the resistance of pathogens, impelling researchers to create novel therapeutic solutions. The management of intestinal tract problems has been the advance use of probiotics in medicine. The aim of this study was evaluate the physicochemical cell surface and adhesion properties of recombinant Lacotococcus lactis NZ1330 containing ...
DOI:
10.1016/j.micpath.2019.103547

25. Antagonistic effects of Satureja hortensis essential oil against AFB, on human lymphocytes in vitro

Author:
S. Ceker; G. Agar; L. Alpsoy; G. Nardemir; H. E. Kizil
Source:
Cytology and genetics 2014 v.48 no.5 pp. 327-332
ISSN:
0095-4527
Subject:
Satureja hortensis; aflatoxin B1; antioxidant activity; crossing over; diarrhea; essential oils; gas chromatography; glutathione peroxidase; humans; indigestion; infectious diseases; lymphocytes; malondialdehyde; mass spectrometry; muscles; nausea; superoxide dismutase
Abstract:
... Satureja hortensis L. (Lamiaceae) has been used as a folk remedy to treat various such as cramps, muscle pains, nausea, indigestion, diarrhea, and infectious diseases. In this study, the antagonistic effects of essential oil of S. hortensis (SHE) were studied against aflatoxin B₁(AFB₁) in human lymphocytes in vitro. The analysis of the essential oil was performed by using Gas chromatography-mass s ...
DOI:
10.3103/S0095452714050028

26. Anthropogenic Land Use Change and Infectious Diseases: A Review of the Evidence

Author:
Nicole L. Gottdenker; Daniel G. Streicker; Christina L. Faust; C. R. Carroll
Source:
EcoHealth 2014 v.11 no.4 pp. 619-632
ISSN:
1612-9202
Subject:
anthropogenic activities; behavior change; community structure; deforestation; disease transmission; ecosystems; habitat fragmentation; hosts; humans; infectious diseases; irrigation; land use change; landscapes; livestock; pathogens; pollution; socioeconomic factors; systematic review; urbanization; wildlife
Abstract:
... Humans have altered ecosystems worldwide, and it is important to understand how this land use change impacts infectious disease transmission in humans and animals. We conducted a systematic review 305 scientific articles investigating how specific types of anthropogenic land use change influence infectious disease dynamics. We summarized findings, highlighted common themes, and drew attention to n ...
DOI:
10.1007/s10393-014-0941-z

27. Anti-inflammatory action of lipid nanocarrier-delivered myriocin: therapeutic potential in cystic fibrosis

Author:
Anna Caretti; Alessandra Bragonzi; Marcella Facchini; Ida De Fino; Camilla Riva; Paolo Gasco; Claudia Musicanti; Josefina Casas; Gemma Fabriàs; Riccardo Ghidoni; Paola Signorelli
Source:
BBA - General Subjects 2014 v.1840 pp. 586-594
ISSN:
0304-4165
Subject:
adaptive immunity; animal models; anti-inflammatory activity; ceramides; cystic fibrosis; epithelial cells; humans; immune response; infectious diseases; inflammation; innate immunity; metabolism; mice; morbidity; mucosa; nanocarriers; patients; serine; tumor necrosis factor-alpha
Abstract:
... Sphingolipids take part in immune response and can initiate and/or sustain inflammation. Various inflammatory diseases have been associated with increased ceramide content, and pharmacological reduction of ceramide diminishes inflammation damage in vivo. Inflammation and susceptibility to microbial infection are two elements in a vicious circle. Recently, sphingolipid metabolism inhibitors were us ...
DOI:
10.1016/j.bbagen.2013.10.018
PubMed:
24141140
PubMed Central:
PMC4097882

28. Anti-melanoma activity of Bupleurum chinense, Bupleurum kaoi and nanoparticle formulation of their major bioactive compound saikosaponin-d

Author:
Stephen Chu-Sung Hu; I-Ta Lee; Ming-Hong Yen; Chun-Ching Lin; Chiang-Wen Lee; Feng-Lin Yen
Source:
Journal of ethnopharmacology 2016 v.179 pp. 432-442
ISSN:
0378-8741
Subject:
Bupleurum chinense; Fourier transform infrared spectroscopy; X-ray diffraction; apoptosis; bioactive compounds; caspases; cell viability; cytochrome c; differential scanning calorimetry; high performance liquid chromatography; humans; hydrogen bonding; indigenous species; infectious diseases; medicinal plants; melanoma; membrane potential; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; nanoparticles; particle size; phosphorylation; signal transduction; traditional medicine; transmission electron microscopy; water solubility; Taiwan
Abstract:
... Bupleurum chinense is a traditional Chinese medicinal herb which has been used to treat various inflammatory and infectious diseases, while Bupleurum kaoi is an endemic plant in Taiwan. We determined whether B. chinense and B. kaoi and their biologically active saikosaponin compounds possess anti-melanoma activity. In addition, we developed a novel saikosaponin-d nanoparticle system to improve its ...
DOI:
10.1016/j.jep.2015.12.058

29. Anti-protease and Immunomodulatory Activities of Bacteria Associated with Caribbean Sponges

Author:
Paula Tabares; Sheila M. Pimentel-Elardo; Tanja Schirmeister; Thomas Hünig; Ute Hentschel
Source:
Marine biotechnology 2011 v.13 no.5 pp. 883-892
ISSN:
1436-2228
Subject:
Actinomycetales; Porifera; Sphingomonadales; autoimmunity; bacteria; bioactive properties; cathepsins; genes; humans; immunomodulation; infectious diseases; mononuclear leukocytes; ribosomal RNA; secondary metabolites; Caribbean
Abstract:
... Marine sponges and their associated bacteria have been proven to be a rich source of novel secondary metabolites with therapeutic usefulness in cancer, infection, and autoimmunity. In this study, 79 strains belonging to 20 genera of the order Actinomycetales and seven strains belonging to two genera of the order Sphingomonadales were cultivated from 18 different Caribbean sponges and identified by ...
DOI:
10.1007/s10126-010-9349-0
PubMed:
21222136

30. Antibacterial activity and cytotoxicity of Pterocarpus erinaceus Poir extracts, fractions and isolated compounds

Author:
Nassifatou Koko Tittikpina; Frédéric Nana; Stéphane Fontanay; Stéphanie Philippot; Komlan Batawila; Koffi Akpagana; Gilbert Kirsch; Patrick Chaimbault; Claus Jacob; Raphaël Emmanuel Duval
Source:
Journal of ethnopharmacology 2017 pp. -
ISSN:
0378-8741
Subject:
Gram-positive bacteria; Pseudomonas aeruginosa; Pterocarpus erinaceus; animal pathogens; antibacterial properties; antibiotic resistance; bark; beta-sitosterol; campesterol; chemical structure; chromatography; cytotoxicity; ethnobotany; fractionation; humans; infectious diseases; leaves; mass spectrometry; methicillin; methicillin-resistant Staphylococcus aureus; minimum inhibitory concentration; nuclear magnetic resonance spectroscopy; roots; stigmasterol; surveys; traditional medicine
Abstract:
... Pterocarpus erinaceus has been chosen based on ethnobotanical surveys carried out in the Tchamba district of the Republic of Togo.Investigation of the antibacterial as well as cytotoxic activities of whole extracts, fractions and compounds isolated from the leaves, trunk bark and roots of Pterocarpus erinaceus.Bio-guided fractionation of the raw extracts of plant parts and subsequent isolation of ...
DOI:
10.1016/j.jep.2017.10.020

31. Antibiotic resistance and virulence traits of bacterial pathogens from infected freshwater fish, Labeo rohita

Author:
Dharmaraj Ramesh; Sami Souissi
Source:
Microbial pathogenesis 2018 v.116 pp. 113-119
ISSN:
0882-4010
Subject:
Aeromonas enteropelogenes; Labeo rohita; Providencia rettgeri; antibiotic resistance; beta-lactam antibiotics; freshwater fish; gene amplification; humans; infectious diseases; lethal dose 50; lipopolysaccharides; outer membrane proteins; pathogens; virulence
Abstract:
... Bacterial infectious diseases are a main dangerous problem in Aquaculture farming. It causes multiple diseases in fish as well as in human being and it has considerable virulence potential. In this connection, the moot of study focus to discriminate bacterial isolates recovered from naturally diseased Labeo rohita fish and their virulent characteristics. Based on the β–haemolysis factor, four isol ...
DOI:
10.1016/j.micpath.2018.01.019

32. Antibiotics and the developing infant gut microbiota and resistome

Author:
Molly K Gibson; Terence S Crofts; Gautam Dantas
Source:
Current opinion in microbiology 2015 v.27 pp. 51-56
ISSN:
1369-5274
Subject:
adults; antibiotic resistance genes; antibiotics; community structure; diet; digestive system; genotype; human health; humans; infectious diseases; intestinal microorganisms; microbial communities
Abstract:
... The microbial communities colonizing the human gut are tremendously diverse and highly personal. The composition and function of the microbiota play important roles in human health and disease, and considerable research has focused on understanding the ecological forces shaping these communities. While it is clear that factors such as diet, genotype of the host, and environment influence the adult ...
DOI:
10.1016/j.mib.2015.07.007
PubMed:
26241507
PubMed Central:
PMC4659777

33. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens

Author:
Colette Cywes-Bentley; David Skurnik; Tanweer Zaidi; Damien Roux; Rosane B. DeOliveira; Wendy S. Garrett; Xi Lu; Jennifer O’Malley; Kathryn Kinzel; Tauqeer Zaidi; Astrid Rey; Christophe Perrin; Raina N. Fichorova; Alexander K. K. Kayatani; Tomas Maira-Litràn; Marina L. Gening; Yury E. Tsvetkov; Nikolay E. Nifantiev; Lauren O. Bakaletz; Stephen I. Pelton; Douglas T. Golenbock; Gerald B. Pier
Source:
Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.24 pp. E2209
ISSN:
0027-8424
Subject:
Candida albicans; Listeria monocytogenes; Neisseria gonorrhoeae; Neisseria meningitidis; Plasmodium berghei; Plasmodium falciparum; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes; Trichomonas vaginalis; antigens; cell adhesion; colitis; complement; fungi; humans; immunity; immunoglobulin G; loci; mice; models; monoclonal antibodies; opsonins; pathogens; polysaccharides; serotypes; sporozoites; vaccination; vaccines
Abstract:
... Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple pathogens. A β-(1→6)–linked poly- N -acetyl- d -glucosamine (PNAG) surface capsule is synthesized by four proteins encoded in genetic loci designated intercellular adhesion in Staphylococcus aureus or polyglucosamine in selected Gram-negative ...
DOI:
10.1073/pnas.1303573110
PubMed:
23716675
PubMed Central:
PMC3683766

34. Antifungal activity of lariciresinol derived from Sambucus williamsii and their membrane-active mechanisms in Candida albicans

Author:
Bomi Hwang; Jaeyong Cho; In-sok Hwang; Hong-Guang Jin; Eun-Rhan Woo; Dong Gun Lee
Source:
Biochemical and biophysical research communications 2011 v.410 no.3 pp. 489-493
ISSN:
0006-291X
Subject:
Candida albicans; Sambucus; antifungal properties; erythrocytes; flow cytometry; fluorescence; fungi; humans; infectious diseases; iodides; lipid bilayers; mechanism of action; medicinal plants; medicinal properties; plasma membrane; propidium
Abstract:
... Lariciresinol is an enterolignan precursor isolated from the herb Sambucus williamsii, a folk medicinal plant used for its therapeutic properties. In this study, the antifungal properties and mode of action of lariciresinol were investigated. Lariciresinol displays potent antifungal properties against several human pathogenic fungal strains without hemolytic effects on human erythrocytes. To under ...
DOI:
10.1016/j.bbrc.2011.06.004

35. Antifungal and anti-inflammatory potential of eschweilenol C-rich fraction derived from Terminalia fagifolia Mart

Author:
Alyne Rodrigues de Araújo; Bruno Iles; Kerolayne de Melo Nogueira; Jhones do Nascimento Dias; Alexandra Plácido; Artur Rodrigues; Patrícia Albuquerque; Ildinete Silva-Pereira; Renato Socodatto; Camila C. Portugal; João B. Relvas; Leiz Maria Costa Véras; Filipe Camargo Dalmatti Alves Lima; Augusto Batagin-Neto; Jand-Venes Rolim Medeiros; Paulo Humberto Moreira Nunes; Peter Eaton; José Roberto de Souza de Almeida Leite
Source:
Journal of ethnopharmacology 2019 v.240 pp. 111941
ISSN:
0378-8741
Subject:
Candida albicans; Galleria mellonella; Terminalia; anti-inflammatory activity; antifungal properties; antioxidant activity; biofilm; carrageenan; computer simulation; edema; erythrocytes; fluconazole; high performance liquid chromatography; humans; indomethacin; infectious diseases; lipopolysaccharides; malondialdehyde; medicinal plants; minimum inhibitory concentration; models; neuroglia; nuclear magnetic resonance spectroscopy; peritonitis; phytochemicals; quality of life; secondary metabolites; therapeutics; toxicity; traditional medicine; transcription factor NF-kappa B; yeasts; Brazil
Abstract:
... Folk knowledge transmitted between generations allows traditional populations to maintain the use of medicinal plants for the treatment of several diseases. In this context, the species Terminalia fagifolia Mart., native to Brazil, is used for the treatment of chronic and infectious diseases. Plants rich in secondary metabolites, such as this species and their derivatives, may represent therapeuti ...
DOI:
10.1016/j.jep.2019.111941

36. Antifungal drug resistance: evolution, mechanisms and impact

Author:
Nicole M Revie; Kali R Iyer; Nicole Robbins; Leah E Cowen
Source:
Current opinion in microbiology 2018 v.45 pp. 70-76
ISSN:
1369-5274
Subject:
antifungal agents; drug resistance; evolution; fungi; hosts; humans; infectious diseases; pathogens; public health
Abstract:
... Microorganisms have a remarkable capacity to evolve resistance to antimicrobial agents, threatening the efficacy of the limited arsenal of antimicrobials and becoming a dire public health crisis. This is of particular concern for fungal pathogens, which cause devastating invasive infections with treatment options limited to only three major classes of antifungal drugs. The paucity of antifungals w ...
DOI:
10.1016/j.mib.2018.02.005
PubMed:
29547801
PubMed Central:
PMC6135714

37. Antigen-specific enhancement of natural human IgG antibodies to phosphatidylcholine, phosphatidylglycerol, phosphatidylinositol-4-phosphate, cholesterol, and lipid A by a liposomal vaccine containing lipid A

Author:
Gary R. Matyas; Carl R. Alving
Source:
Vaccine 2011 v.29 no.32 pp. 5137-5144
ISSN:
0264-410X
Subject:
Plasmodium falciparum; adsorption; antibodies; antigens; ceramides; cholesterol; enzyme-linked immunosorbent assay; gangliosides; germ cells; humans; immune response; immunization; immunoglobulin G; infectious diseases; lipid A; phosphatidylcholines; vaccines; volunteers
Abstract:
... Natural IgG antibodies (NA) to lipids are ubiquitously distributed in sera of healthy humans and are believed to serve beneficial functions. Although NA to lipids generally exhibit germ line or near germ line binding specificities, the antibodies commonly increase transiently in the acute phases of most, if not all, infectious diseases and may serve as a first line of defense. In order to determin ...
DOI:
10.1016/j.vaccine.2011.05.042

38. Antigenic fractions from Taenia crassiceps metacestodes obtained by hydrophobicity for the immunodiagnosis of active and inactive forms of neurocysticercosis in human cerebrospinal fluid samples

Author:
Gabriela B. da Silva; Daniela S. Nunes; José Eduardo N. de Sousa; Maria do R.F. Gonçalves-Pires; Marcelo A. Levenhagen; Julia M. Costa-Cruz
Source:
Parasitology international 2017 v.66 no.2 pp. 134-138
ISSN:
1383-5769
Subject:
Taenia crassiceps; antigens; brain; cerebrospinal fluid; detergents; enzyme-linked immunosorbent assay; fractionation; humans; hydrophobicity; immunoglobulin G; infectious diseases; metacestodes; nervous system diseases; neurocysticercosis; patients; selenium; serodiagnosis
Abstract:
... This study aimed to evaluate the total extract of Taenia crassiceps metacestodes (TC) and its antigenic fractions obtained by Triton X-114 fractionation techniques, such as detergent (DC) and aqueous (AC), in the immunodiagnosis of human neurocysticercosis (NCC). Cerebrospinal fluid samples were divided into two groups: Group 1 (n=40), which was further divided into active (n=20) and inactive (n=2 ...
DOI:
10.1016/j.parint.2016.12.009

39. Antileishmanial activity of essential oil and 6,7-dehydroroyleanone isolated from Tetradenia riparia

Author:
Izabel Galhardo Demarchi; Mateus Vailant Thomazella; Mariana de Souza Terron; Lilian Lopes; Zilda Cristiani Gazim; Diógenes Aparício Garcia Cortez; Lucélia Donatti; Sandra Mara Alessi Aristides; Thaís Gomes Verzignassi Silveira; Maria Valdrinez Campana Lonardoni
Source:
Experimental parasitology 2015 v.157 pp. 128-137
ISSN:
0014-4894
Subject:
Leishmania amazonensis; adverse effects; alternative medicine; antileishmanial properties; autophagy; chromatin; cytotoxicity; death; drugs; erythrocytes; essential oils; gene expression; humans; inducible nitric oxide synthase; infectious diseases; leishmaniasis; lethal dose 50; macrophages; messenger RNA; mice; nitrites; traditional medicine; transmission electron microscopy; ultrastructure; Africa
Abstract:
... Tetradenia riparia plant is used as a traditional medicine in Africa for the treatment of inflammatory and infectious diseases as like parasitic. Therapy for leishmaniasis caused by Leishmania (Leishmania) amazonensis specie often fails, and the conventional drugs are toxic, expensive, require a long period of treatment, and adverse effects are common. The alternative therapies using natural produ ...
DOI:
10.1016/j.exppara.2015.06.014

40. Antimalarial activity of basic phospholipases A2 isolated from Paraguayan Bothrops diporus venom against Plasmodium falciparum

Author:
Keila A. Vitorino; Jorge J. Alfonso; Ana F. Gómez; Ana Paula A. Santos; Ygor R. Antunes; Cleópatra A. da S. Caldeira; Celeste V. Gómez; Carolina B.G. Teles; Andreimar M. Soares; Leonardo A. Calderon
Source:
Toxicon: X 2020 v.8 pp. 100056
ISSN:
2590-1710
Subject:
Bothrops; Plasmodium falciparum; antimalarials; cell death; cytotoxicity; electrophoresis; enzyme activity; hemolysis; humans; infectious diseases; ion exchange chromatography; malaria; mechanism of action; phospholipases; reversed-phase liquid chromatography; snakes
Abstract:
... Malaria is a parasitic infectious disease and was responsible for 400.000 deaths in 2018. Plasmodium falciparum represents the species that causes most human deaths due to severe malaria. In addition, studies prove the resistance of P. falciparum to drugs used to treat malaria, making the search for new drugs with antiplasmodial potential necessary. In this context, the literature describes snake ...
DOI:
10.1016/j.toxcx.2020.100056

41. Antimicrobial Resistance Creates Threat to Chimpanzee Health and Conservation in the Wild

Author:
Michele B. Parsons; Dominic A. Travis; Elizabeth V. Lonsdorf; Iddi Lipende; Deema Elchoufi; Baraka Gilagiza; Anthony Collins; Shadrack Kamenya; Robert V. Tauxe; Thomas R. Gillespie
Source:
Pathogens 2021 v.10 no.4 pp. -
ISSN:
2076-0817
Subject:
Pan troglodytes; antibiotic resistance; conservation areas; diarrhea; humans; infectious diseases; national parks; streams; tetracycline; Tanzania
Abstract:
... Infectious disease is recognized as the greatest threat to the endangered chimpanzees made famous by the groundbreaking work of Dr. Jane Goodall at Gombe National Park (GNP), Tanzania. The permeable boundary of this small protected area allows for regular wildlife–human and wildlife–domestic animal overlap, which may facilitate cross-species transmission of pathogens and antimicrobial resistance. ...
DOI:
10.3390/pathogens10040477

42. Antimicrobial activity of recombinant Pg-AMP1, a glycine-rich peptide from guava seeds

Author:
Letícia Stephan Tavares; João Vitor Rettore; Renata Mendes Freitas; William Farias Porto; Ana Paula do Nascimento Duque; Júnya de Lacorte Singulani; Osmar Nascimento Silva; Michelle de Lima Detoni; Eveline Gomes Vasconcelos; Simoni Campos Dias; Octávio Luiz Franco; Marcelo de Oliveira Santos
Source:
Peptides 2012 v.37 no.2 pp. 294-300
ISSN:
0196-9781
Subject:
Escherichia coli; Klebsiella pneumoniae; Pseudomonas aeruginosa; Psidium guajava; Staphylococcus aureus; anti-infective properties; antibiotics; antimicrobial peptides; bacteria; fungi; guavas; humans; infectious diseases; methionine; molecular weight; open reading frames; parasites; seeds; viruses
Abstract:
... Antimicrobial peptides (AMPs) are compounds that act in a wide range of physiological defensive mechanisms developed to counteract bacteria, fungi, parasites and viruses. These molecules have become increasingly important as a consequence of remarkable microorganism resistance to common antibiotics. This report shows Escherichia coli expressing the recombinant antimicrobial peptide Pg-AMP1 previou ...
DOI:
10.1016/j.peptides.2012.07.017

43. Antimicrobial and immunomodulating activities of hesperidin and ellagic acid against diarrheic Aeromonas hydrophila in a murine model

Author:
Abdelaziz S.A. Abuelsaad; Imad Mohamed; Gamal Allam; Adnan A. Al-Solumani
Source:
Life sciences 2013 v.93 no.20 pp. 714-722
ISSN:
0024-3205
Subject:
Aeromonas hydrophila; animal models; anti-infective properties; antigens; bacterial colonization; clinical trials; ellagic acid; gastrointestinal system; hesperidin; histopathology; humans; humoral immunity; immunocompromised population; immunoglobulin A; immunoglobulin M; infectious diseases; medicinal plants; mice; minimum inhibitory concentration; normal values; pathogens; sepsis (infection)
Abstract:
... AIMS: The present study is designed to evaluate the in vitro and in vivo bactericidal and immunomodulating activities of hesperidin (HES) and ellagic acid (EA) against Aeromonas hydrophila. A hydrophila, an uncommon human pathogen, can cause invasive infections in immunocompromised individuals and common clinical presentations in acute gastrointestinal illness, soft-tissue infections and sepsis. T ...
DOI:
10.1016/j.lfs.2013.09.019

44. Antimicrobial discovery inspired by ecological interactions

Author:
Evelyn M Molloy; Christian Hertweck
Source:
Current opinion in microbiology 2017 v.39 pp. 121-127
ISSN:
1369-5274
Subject:
antibiotics; antifungal agents; bacteria; coculture; cultivars; engineering; genome mining; humans; infectious diseases; insects; invertebrates; progeny; symbiosis
Abstract:
... Bacteria represent an unparalleled source of antibiotics used to treat infectious diseases. Yet, genome analyses have revealed that their full biosynthetic potential is much larger than expected. Valuable strategies to unearth hidden antibiotics are genome mining, pathway engineering and triggering, as well as co-cultivation approaches. Nevertheless, there is growing understanding that it is often ...
DOI:
10.1016/j.mib.2017.09.006

45. Antimicrobial peptides: key components of the innate immune system

Author:
Mukesh Pasupuleti; Artur Schmidtchen; Martin Malmsten
Source:
Critical reviews in biotechnology 2012 v.32 no.2 pp. 143-171
ISSN:
1549-7801
Subject:
amino acids; antibiotic resistance; antibiotics; antimicrobial peptides; antimicrobial properties; coevolution; drugs; humans; hydrophobicity; infectious diseases; innate immunity; mechanism of action; microorganisms; pathogens; surfactants
Abstract:
... Life-threatening infectious diseases are on their way to cause a worldwide crisis, as treating them effectively is becoming increasingly difficult due to the emergence of antibiotic resistant strains. Antimicrobial peptides (AMPs) form an ancient type of innate immunity found universally in all living organisms, providing a principal first-line of defense against the invading pathogens. The unique ...
DOI:
10.3109/07388551.2011.594423

46. Antimicrobial, antioxidant and antitumor activities of silver nanoparticles synthesized by Allium cepa extract: A green approach

Author:
Eman Zakaria Gomaa
Source:
Journal of Genetic Engineering and Biotechnology (Print) 2017 v.15 no.1 pp. 49-57
ISSN:
1687-157X
Subject:
Allium cepa; Fourier transform infrared spectroscopy; X-ray diffraction; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; breasts; colon; dose response; free radicals; humans; infectious diseases; inhibitory concentration 50; nanosilver; neoplasm cells; neoplasms; onions; surface plasmon resonance; transmission electron microscopy; ultraviolet-visible spectroscopy
Abstract:
... An economic and efficient method for the synthesis of silver nanoparticles (AgNPs) was performed using onion (Allium cepa) extract as reducing and capping agent. UV–vis spectroscopy confirmed the formation of silver nanoparticles by observing the typical surface plasmon resonance peak at 420nm. Transmission electron microscopy studies revealed that AgNPs were spherical in shape with a size range o ...
DOI:
10.1016/j.jgeb.2016.12.002
PubMed:
30647641
PubMed Central:
PMC6296636

47. Antioxidant defence systems in the protozoan pathogen Giardia intestinalis

Author:
Daniela Mastronicola; Micol Falabella; Elena Forte; Fabrizio Testa; Paolo Sarti; Alessandro Giuffrè
Source:
Molecular and biochemical parasitology 2016 v.206 pp. 56-66
ISSN:
0166-6851
Subject:
Giardia lamblia; antioxidants; catalase; giardiasis; glutathione peroxidase; humans; infectious diseases; mucosa; parasites; pathogens; protists; small intestine; superoxide dismutase
Abstract:
... The microaerophilic protist Giardia intestinalis is the causative agent of giardiasis, one of the most common intestinal infectious diseases worldwide. The pathogen lacks not only respiratory terminal oxidases (being amitochondriate), but also several conventional antioxidant enzymes, including catalase, superoxide dismutase and glutathione peroxidase. In spite of this, since living attached to th ...
DOI:
10.1016/j.molbiopara.2015.12.002

48. Antiplasmodial activity of eco-friendly synthesized palladium nanoparticles using Eclipta prostrata extract against Plasmodium berghei in Swiss albino mice

Author:
Govindasamy Rajakumar; Abdul Abdul Rahuman; Ill-Min Chung; Arivarasan Vishnu Kirthi; Sampath Marimuthu; Karunanithi Anbarasan
Source:
Parasitology research 2015 v.114 no.4 pp. 1397-1406
ISSN:
0932-0113
Subject:
Eclipta prostrata; Fourier transform infrared spectroscopy; Plasmodium berghei; X-radiation; X-ray diffraction; acetates; antimalarials; body weight; catalysts; cytotoxicity; drugs; economic sustainability; energy; energy-dispersive X-ray analysis; green chemistry; growth retardation; humans; infectious diseases; inhibitory concentration 50; leaf extracts; leaves; malaria; manufacturing; mice; morbidity; mortality; nanoparticles; palladium; parasitemia; parasites; pollutants; scanning electron microscopy; transmission electron microscopes
Abstract:
... Malaria is an infectious disease caused by the Plasmodium parasite that continues to be a health issue for humans. It is one of the most common pathogenic factors of morbidity and mortality. Palladium nanoparticles (Pd NPs) have been used as target antimicrobial compounds, as a catalyst to manufacture pharmaceuticals, degrade harmful environmental pollutants, and as sensors for the detection of va ...
DOI:
10.1007/s00436-015-4318-1

49. Antiproliferative activity of the hexanic extract and phloroglucinols from Hypericum brasiliense

Author:
Hildegardo Seibert França; Leandro Rocha; Caio P. Fernande; Ana Lúcia T.G. Ruiz; João E. de Carvalho
Source:
Revista Brasileira de Farmacognosia 2013 v.23 no.5 pp. 844-847
ISSN:
0102-695X
Subject:
Hypericum; chemical elements; drug therapy; flavonoids; humans; infectious diseases; melanoma; neoplasm cells; parasympatholytics; traditional medicine; xanthones; Brazil
Abstract:
... Natural products are regarded as major and important sources of molecules used in chemotherapy. Hypericum brasiliense Choisy, Hypericaceae, is an annual bush, native in the southern and southeastern Brazil. This species has been used in Brazilian folk medicine the anti-spasmodic and for the treatment of infectious diseases. H. brasiliense is chemically composed by flavonoids and xanthones. In addi ...
DOI:
10.1590/S0102-695X2013000500018

50. Antiprotozoal investigation of three Combretum species (Combretaceae) growing in Nigeria

Author:
Omonike O. Ogbole; Toluwanimi E. Akinleye; Peter A. Segun; Pius S. Fasinu
Source:
Herba Polonica 2019 v.65 no.4 pp. 37-44
ISSN:
0018-0599
Subject:
Cercopithecus aethiops; Combretum; Leishmania donovani; Plasmodium falciparum; Trypanosoma brucei brucei; antiplasmodial properties; antitrypanosomal properties; cell lines; cytotoxicity; humans; inhibitory concentration 50; kidneys; lactate dehydrogenase; leaf extracts; leukemia; neoplasm cells; parasites; parasitoses; Nigeria
Abstract:
... Introduction: Combretum species has been utilised for decades in African indigenous medical practices for the treatment of several parasitic infections. Objectives: This study aims at investigating the antileishmanial, antiplasmodial and antitrypanosomal properties of Combretum racemosum, Combretum platypterum and Combretum zenkeri. Methods: The leaf extracts of the plants were screened against tw ...
DOI:
10.2478/hepo-2019-0024