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- Catlin, Natasha R.; Herbert, Ron; Janardhan, Kyathanahalli; Hejtmancik, Milton R.; Fomby, Laurene M.; Vallant, Molly; Kissling, Grace E.; DeVito, Michael J.
- Food and chemical toxicology 2016 v.98 pp. 159-168
- rats, etc ; cedarwood oil; cosmetics; dermal exposure; dose response; ethanol; females; humans; hyperplasia; inflammation; males; mice; models; odors; pesticides; risk assessment; skin lesions; toxicity; toxicology; Show all 19 Subjects
- ... Virginia cedarwood oil is widely used as a fragrance material in household and personal products and as a naturally derived pesticide alternative. Due to conflicting literature on dermal exposures in animals and humans, concern for safe levels of human exposure remains. The present study evaluated the toxicity of cedarwood oil applied dermally to F344/N rats and B6C3F1/N mice for 13 weeks. Groups ...
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- Hooth, Michelle J.; Nyska, Abraham; Fomby, Laurene M.; Vasconcelos, Daphne Y.; Vallant, Molly; DeVito, Michael J.; Walker, Nigel J.
- Toxicology 2012 v.301 no.1-3 pp. 85-93
- rats, etc ; World Health Organization; atrophy; corn; dose response; enzyme activity; histopathology; humans; liver; models; naphthalenes; tetrachlorodibenzo-p-dioxin; toxicity; toxicology; Show all 14 Subjects
- ... In this study we assessed the relative toxicity and potency of the chlorinated naphthalenes 1,2,3,4,6,7-hexachloronaphthalene (PCN 66) and 1,2,3,5,6,7-hexachloronaphthalene (PCN 67) relative to that of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Chemicals were administered in corn oil:acetone (99:1) by gavage to female Harlan Sprague–Dawley rats at dosages of 0 (vehicle), 500, 1500, 5000, 50,000 a ...
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