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81. Effects of urotensin II on functional activity of late endothelial progenitor cells

Author:
Yi, Kaihong; Yu, Min; Wu, Libiao; Tan, Xuerui
Source:
Peptides 2012 v.33 no.1 pp. 87-91
ISSN:
0196-9781
Subject:
umbilical cord,   etc   ; antagonists; blood; density gradient centrifugation; ficoll; fluorescent antibody technique; humans; migratory behavior; stem cells;     Show all 9 Subjects
Abstract:
... Urotensin II (UII) is a potent vasoactive cyclic peptide which has multiple effects on the cardiovascular system. However, the effects of UII on late endothelial progenitor cells (EPCs) are still unclear. The aim of the present study is to investigate whether UII influences the functional activity of late EPCs. Late EPCs were isolated from human umbilical cord blood by Ficoll density gradient cent ...
DOI:
10.1016/j.peptides.2011.11.016

82. Electrophoresis studies on the contaminating glycosaminoglycans in commercially available hyaluronic acid products

Author:
Matsuno, Yu-Ki; Kakoi, Naotaka; Kinoshita, Mitsuhiro; Matsuzaki, Yuji; Kumada, Jun-Ichi; Kakehi, Kazuaki
Source:
Electrophoresis 2008 v.29 no.17 pp. 3628-3635
ISSN:
0173-0835
Subject:
umbilical cord,   etc   ; Streptococcus dysgalactiae; Streptomyces; capillary electrophoresis; cellulose acetate; comb (integument); digestion; drugs; half life; humans; hyaluronic acid; hyaluronoglucosaminidase; lyases; oligosaccharides; roosters;     Show all 15 Subjects
Abstract:
... Hyaluronic acid (HA) samples showing inhibition effect on digestion with testicular hyaluronidase (HAase) were found from 16 commercially available HA products, which were supplied from 11 different manufacturers. Most of these HA samples (six samples) were derived from the rooster comb, and one sample was derived from the human umbilical cord. HA oligosaccharides produced by exhaustive digestion ...
DOI:
10.1002/elps.200700941

83. Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity

Author:
Liang, Shaojun; Zhou, Hui; Yin, Nuoya; Lu, Yuanping; Faiola, Francesco
Source:
Journal of hazardous materials 2019 v.376 pp. 223-232
ISSN:
0304-3894
Subject:
umbilical cord,   etc   ; blood serum; breast milk; developmental toxicity; embryogenesis; embryonic stem cells; gene expression; humans; mice; models; prolactin; sequence analysis; skeletal muscle;     Show all 13 Subjects
Abstract:
... The frequent detection of tetrabromobisphenol A (TBBPA) in the human body, especially in umbilical cord serum and breast milk, has raised concerns about TBBPA potential effects on embryonic development. The differentiation of embryonic stem cells (ESCs) in vitro can serve as a model for the early stages of embryonic development. In this study, we differentiated mouse ESCs via 3D aggregates called ...
DOI:
10.1016/j.jhazmat.2019.05.030

84. Endogenous protein C is essential for the functional integrity of human endothelial cells

Author:
Xue, Meilang; Minhas, Nikita; Chow, Shu-Oi; Dervish, Suat; Sambrook, Philip N.; March, Lyn; Jackson, Christopher J.
Source:
Cellular and molecular life sciences 2010 v.67 no.9 pp. 1537-1546
ISSN:
1420-682X
Subject:
umbilical cord,   etc   ; anticoagulants; apoptosis; basement membrane; blood vessels; collagen; endothelial cells; gelatinase A; humans; permeability; small interfering RNA; tight junctions;     Show all 12 Subjects
Abstract:
... Circulating protein C (PC) plays a vital role as an anti-coagulant and anti-inflammatory mediator. We show here that human endothelial cells produce PC that acts through novel mediators to enhance their own functional integrity. When endogenous PC or its receptor, endothelial protein C receptor (EPCR), was suppressed by small interfering (si) RNA, human umbilical cord endothelial cell (HUVEC) prol ...
DOI:
10.1007/s00018-010-0269-y

85. Endothelial colony forming cells from human umbilical cord blood improved severe erectile dysfunction in obese type II diabetic rats

Author:
Siddiquee, Abrar Al-Mahmood; Adaikan, P. Ganesan; Lau, Lang Chu; Said, Baharudin Bin; Chong, Mark; Chan, Jerry; Teoh, Swee Hin
Source:
Life sciences 2018 v.207 pp. 272-283
ISSN:
0024-3205
Subject:
umbilical cord,   etc   ; animal disease models; apoptosis; blood; diabetes; dose response; endothelial nitric oxide synthase; endothelium; humans; nerve tissue; neuronal nitric oxide synthase; phosphates; protein synthesis; rats; smooth muscle; staining;     Show all 16 Subjects
Abstract:
... To investigate the effect of intracavernous injection of human umbilical cord blood derived endothelial colony forming cells (HUCB ECFCs) on erectile dysfunction (ED) in Zucker Diabetic Fatty (ZDF) rat model.Erectile function was assessed by cavernous nerve electrostimulation in ZDF rats aged 20–28 weeks. Following confirmation of severe ED at the age of 28 weeks, 21 ZDF rats were randomly assigne ...
DOI:
10.1016/j.lfs.2018.06.017

86. Engineering of living autologous human umbilical cord cell-based septal occluder membranes using composite PGA-P4HB matrices

Author:
Weber, Benedikt; Schoenauer, Roman; Papadopulos, Francesca; Modregger, Peter; Peter, Silvia; Stampanoni, Marco; Mauri, Arabella; Mazza, Edoardo; Gorelik, Julia; Agarkova, Irina; Frese, Laura; Breymann, Christian; Kretschmar, Oliver; Hoerstrup, Simon P.
Source:
Biomaterials 2011 v.32 no.36 pp. 9630-9641
ISSN:
0142-9612
Subject:
umbilical cord,   etc   ; DNA; biodegradability; collagen; engineering; histology; humans; hydroxyproline; interferometry; risk; scanning electron microscopy; swine; therapeutics; viability;     Show all 14 Subjects
Abstract:
... Interventional closure of intracardiac wall defects using occluder devices has evolved as a highly attractive treatment option. However, incomplete and delayed healing reactions often result in a major risk of residual defects, thromboembolism, or device fractures. Biodegradable living tissue engineered occluder membranes (TEOMs) could provide autologous thromboresistant implants with growth and r ...
DOI:
10.1016/j.biomaterials.2011.07.070

87. Enhancement of adipogenic and osteogenic differentiation of human bone-marrow-derived mesenchymal stem cells by supplementation with umbilical cord blood serum

Author:
Tekkatte, Chandana; Vidyasekar, Prasanna; Kapadia, Nand Kishore; Verma, Rama S
Source:
Cell and tissue research 2012 v.347 no.2 pp. 383-395
ISSN:
0302-766X
Subject:
umbilical cord,   etc   ; bone formation; calcium; charcoal; cultured cells; dexamethasone; droplets; estrogens; fetal bovine serum; humans; indomethacin; insulin; lipogenesis; stem cells;     Show all 14 Subjects
Abstract:
... Umbilical cord blood serum (UCBS) is a promising replacement for animal sera for the culture of human mesenchymal stem cells (hMSC), the unique serum composition of UCBS appearing to have variable effects on their proliferation and differentiation. Conditioning UCBS with methods such as charcoal stripping assists specific processes such as adipogenesis and osteogenesis in hMSCs. The charcoal strip ...
DOI:
10.1007/s00441-012-1328-5
PubMed:
22311206

88. Enterococcus hirae: a zoonotic microorganism in human umbilical cord blood

Author:
Savini, Vincenzo; Bonfini, Tiziana; Marrollo, Roberta; Argentieri, Angela Valentina; Riccioni, Sara; Astolfi, Daniela; Fazii, Paolo; D’Antonio, Domenico; Gherardi, Giovanni
Source:
World journal of microbiology & biotechnology 2014 v.30 no.4 pp. 1423-1426
ISSN:
0959-3993
Subject:
umbilical cord,   etc   ; Enterococcus hirae; birds; blood; disinfection; human resources; humans; pathogens; risk;     Show all 9 Subjects
Abstract:
... Enterococcus hirae is rarely collected from man, while it is a common pathogen in mammals and birds. We describe the first isolation of the organism (strain DSM 27815) from human umbilical cord blood (UCB), thus emphasizing the risk of contamination of UCB units for clinical use. In this context, we also highlight the importance of an extensive training of the collecting personnel as to the observ ...
DOI:
10.1007/s11274-013-1537-4
PubMed:
24197782

89. Environmental exposure to polycyclic aromatic hydrocarbons (PAHs): The correlation with and impact on reproductive hormones in umbilical cord serum

Author:
Yin, Shanshan; Tang, Mengling; Chen, Fangfang; Li, Tianle; Liu, Weiping
Source:
Environmental pollution 2017 v.220 pp. 1429-1437
ISSN:
0269-7491
Subject:
umbilical cord,   etc   ; blood serum; databases; endocrine-disrupting chemicals; environmental exposure; estradiol; follicle-stimulating hormone; humans; islands; lipids; naphthalene; neonates; pollutants; polycyclic aromatic hydrocarbons;     Show all 14 Subjects
Abstract:
... Polycyclic aromatic hydrocarbons (PAHs) are a type of ubiquitous pollutant with the potential ability to cause endocrine disruption that would have an adverse health impact on the general population. To assess the maternal exposure to PAHs in neonates and evaluate the possible impact of PAHs on reproductive hormone levels, the concentration of PAHs and reproductive hormone levels in the umbilical ...
DOI:
10.1016/j.envpol.2016.10.090

90. Epidermal growth factor promotes the differentiation of stem cells derived from human umbilical cord blood into neuron-like cells via taurine induction in vitro Animal

Author:
Jin, Wei; Xing, Yi-qiao; Yang, An-huai
Source:
In vitro cellular & developmental biology 2009 v.45 no.7 pp. 321-327
ISSN:
1071-2690
Subject:
umbilical cord,   etc   ; antibodies; blood; bone marrow; culture media; cultured cells; epidermal growth factor; flow cytometry; humans; macular degeneration; pH; phosphopyruvate hydratase; rhodopsin; stem cells; taurine;     Show all 15 Subjects
Abstract:
... Results of recent investigations have demonstrated the plasticity of mesenchymal stem cells (MSC) can differentiate into neural lineages. In this study, we explored the experimental condition of differentiation into neuron-like cells or rhodopsin (RHOS)-positive cells induced by epidermal growth factor (EGF) and taurine in vitro and to investigate their biological characteristics. MSC were obtaine ...
DOI:
10.1007/s11626-009-9184-7

91. Epigenome-wide study for the offspring exposed to maternal HBV infection during pregnancy, a pilot study

Author:
Cheng, Qijun; Zhao, Bin; Huang, Zhenxiang; Su, Yanhua; Chen, Biqin; Yang, Songjing; Peng, Xueqi; Ma, Qilin; Yu, Xiaoshan; Zhao, Benhua; Ke, Xiayi
Source:
Gene 2018 v.658 pp. 76-85
ISSN:
0378-1119
Subject:
umbilical cord,   etc   ; DNA methylation; Hepatitis B virus; abnormal development; beta oxidation; biomarkers; blood; colorectal neoplasms; epigenetics; genes; humans; maternal exposure; mothers; neonatal development; neonates; pregnancy; premature birth; progeny; risk; sequence analysis;     Show all 20 Subjects
Abstract:
... Hepatitis B virus (HBV) can be transmitted to infants, and is related to infants' later disease risk. Epigenetic change (such as DNA methylation) may be mechanism underlying the relationship. In this study, we aimed to investigate whether prenatal HBV infection could alter DNA methylation status in newborns.We selected 12 neonates with intrauterine HBV infection whose mothers were HBsAg-positive d ...
DOI:
10.1016/j.gene.2018.03.025

92. Evaluation of committed and primitive cord blood progenitors after expansion on adipose stromal cells

Author:
Andreeva, E.R.; Andrianova, I.V.; Gornostaeva, A.N.; Gogiya, B.Sh.; Buravkova, L.B.
Source:
Cell and tissue research 2018 v.372 no.3 pp. 523-533
ISSN:
0302-766X
Subject:
umbilical cord,   etc   ; blood; coculture; hematopoiesis; hematopoietic stem cells; humans; phenotype; stromal cells; therapeutics;     Show all 9 Subjects
Abstract:
... Umbilical cord blood mononuclear fraction is a valuable source of hematopoietic stem and progenitor cells (CB HSPCs). The rarity of this population is a serious limitation of its application in cell therapy. Ex vivo expansion enables to significantly amplify the number of hematopoietic precursors of different commitment. Here, we expand CB MNCs in co-culture with human adipose tissue-derived strom ...
DOI:
10.1007/s00441-017-2766-x

93. Evaluation of intracellular and extracellular trehalose as a cryoprotectant of stem cells obtained from umbilical cord blood

Author:
Motta, Juliana Pessanha Rodrigues; Paraguassú-Braga, Flávio Henrique; Bouzas, Luis Fernando; Porto, Luís Cristóvão
Source:
Cryobiology 2014 v.68 no.3 pp. 343-348
ISSN:
0011-2240
Subject:
umbilical cord,   etc   ; adverse effects; blood cells; cryopreservation; cryoprotectants; dimethyl sulfoxide; flow cytometry; freezing; hematopoietic stem cells; humans; thawing; toxicity; trehalose; viability;     Show all 14 Subjects
Abstract:
... Cord blood is a source of hematopoietic stem cells used in transplantation in which hematopoietic reconstitution is necessary. This transplant modality requires the cryopreservation of hematopoietic stem cells (HSCs). Dimethyl sulfoxide has been used as a cryoprotectant (CPA) in the cryopreservation of HSCs; however, it has been demonstrated that Me2SO exhibits toxic side effects to the human body ...
DOI:
10.1016/j.cryobiol.2014.04.007

94. Evaluation of suitable reference gene for real-time PCR in human umbilical cord mesenchymal stem cells with long-term in vitro expansion Animal

Author:
Wang, Youwei; Han, Zhibo; Yan, Shulin; Mao, Aibin; Wang, Bin; Ren, He; Chi, Ying; Han, Zhongchao
Source:
In vitro cellular & developmental biology 2010 v.46 no.7 pp. 595-599
ISSN:
1071-2690
Subject:
umbilical cord,   etc   ; actin; gene expression; genes; humans; quantitative polymerase chain reaction; stem cells;     Show all 7 Subjects
Abstract:
... In real-time quantitative PCR, the accuracy of normalized data is highly dependent on the stability of the reference genes. However, reference gene expression in a given cell type or experimental condition can vary considerably. The goal of this study was to establish a reliable set of reference genes for real-time PCR studies using human umbilical cord mesenchymal stem cells with long-term in vit ...
DOI:
10.1007/s11626-010-9318-y

95. Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin

Author:
Kim, Yoon-Jin; Yoo, Sae mi; Park, Hwan Hee; Lim, Hye Jin; Kim, Yu-Lee; Lee, Seunghee; Kang, Kyung-Sun; Seo, Kwang-Won
Source:
Biochemical and biophysical research communications 2017
ISSN:
0006-291X
Subject:
umbilical cord,   etc   ; blood; cell growth; cell movement; collagen; cosmetics; elastin; exosomes; fibroblasts; growth factors; humans; signal transduction; skin (animal); stem cells; therapeutics; tissue repair;     Show all 16 Subjects
Abstract:
... Human umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) play an important role in cutaneous wound healing, and recent studies suggested that MSC-derived exosomes activate several signaling pathways, which are conducive in wound healing and cell growth. In this study, we investigated the roles of exosomes that are derived from USC-CM (USC-CM Exos) in cutaneous collagen synthesis and pe ...
DOI:
10.1016/j.bbrc.2017.09.056

96. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate acute liver failure by reducing the activity of the NLRP3 inflammasome in macrophages

Author:
Jiang, Linrui; Zhang, Shuqin; Hu, Huazhong; Yang, Jing; Wang, XiaoYan; Ma, Yanyan; Jiang, JiaoHua; Wang, JinHong; Zhong, Lin; Chen, Ming; Wang, Hong; Hou, Yu; Zhu, RuiRui; Zhang, Qun
Source:
Biochemical and biophysical research communications 2019 v.508 no.3 pp. 735-741
ISSN:
0006-291X
Subject:
umbilical cord,   etc   ; Western blotting; alanine transaminase; aspartate transaminase; caspase-1; enzyme-linked immunosorbent assay; exosomes; humans; inflammasomes; inflammation; interleukin-1beta; interleukin-6; liver; liver failure; macrophages; mesenchymal stromal cells; mice; models;     Show all 18 Subjects
Abstract:
... Human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-EXOs) play an important role in the regulation of the immune system and inflammatory responses; however, their role in acute liver failure (ALF) and related pathological conditions is unclear. In this study, we found that hUCMSC-EXOs can reduce the expression of the NLRP3 inflammasome and downstream inflammatory factors in acute l ...
DOI:
10.1016/j.bbrc.2018.11.189

97. Experimental studies on the tensile properties of human umbilical cords

Author:
Tantius, Britta; Rothschild, Markus A.; Valter, Markus; Michael, Joern; Banaschak, Sibylle
Source:
Forensic science international 2014 v.236 pp. 16-21
ISSN:
0379-0738
Subject:
umbilical cord,   etc   ; abnormal development; birth weight; blood; children; death; energy; humans; inflammation; mothers; neonates; pH; pregnancy; statistical analysis; tensile strength;     Show all 15 Subjects
Abstract:
... When tried in court, mothers accused of neonaticide may claim that the umbilical cord just broke during birth and the newborn child bled to death accordingly. To evaluate the possibility of a breakage of the umbilical cord is the goal of this work. Therefore 25 umbilical cords from neonates of both sexes born at term were stretched using an electrically operated material testing machine and the en ...
DOI:
10.1016/j.forsciint.2013.12.002

98. Exploiting the impact of the secretome of MSCs isolated from different tissue sources on neuronal differentiation and axonal growth

Author:
Assunção-Silva, Rita Catarina; Mendes-Pinheiro, Bárbara; Patrício, Patrícia; Behie, Leo A.; Teixeira, Fábio Gabriel; Pinto, Luísa; Salgado, António José
Source:
Biochimie 2018 v.155 pp. 83-91
ISSN:
0300-9084
Subject:
umbilical cord,   etc   ; adipose tissue; bone marrow; cell transplantation; explants; humans; neurites; neuroprotective effect; proteins; proteomics; stem cells;     Show all 11 Subjects
Abstract:
... Cell transplantation using Mesenchymal stem cell (MSC) secretome have recently been presented as a possible free-based therapy for CNS related disorders. MSC secretome is rich in several bio-factors that act synergically towards the repair of damaged tissues, thus making it an ideal candidate for regenerative applications. Great effort is currently being made to map the molecules that compose the ...
DOI:
10.1016/j.biochi.2018.07.026

99. Exploration of potential biomarkers and related biological pathways for PCB exposure in maternal and cord serum: A pilot birth cohort study in Chiba, Japan

Author:
Eguchi, Akifumi; Sakurai, Kenichi; Watanabe, Masahiro; Mori, Chisato
Source:
Environment international 2017
ISSN:
0160-4120
Subject:
umbilical cord,   etc   ; adverse effects; amino acid metabolism; biochemical pathways; biomarkers; biosynthesis; blood serum; children; cohort studies; ethanolamine; fetus; glutathione; humans; hydrophilicity; metabolites; metabolome; metabolomics; models; polychlorinated biphenyls; pregnant women; tandem mass spectrometry; ubiquinones; Japan; United States;     Show all 24 Subjects
Abstract:
... Polychlorinated biphenyls (PCBs) have been associated with adverse human reproductive and fetal developmental measures or outcomes because of their endocrine-disrupting effects; however, the biological mechanisms of adverse effects of PCB exposure in humans are not currently well established. In this study, we aimed to identify the biological pathways and potential biomarkers of PCB exposure in ma ...
DOI:
10.1016/j.envint.2017.02.011

100. Exposure assessment of fetus and newborn to brominated flame retardants in France: preliminary data

Author:
Antignac, Jean-Philippe; Cariou, Ronan; Maume, Daniel; Marchand, Philippe; Monteau, Fabrice; Zalko, Daniel; Berrebi, Alain; Cravedi, Jean-Pierre; Andre, François; Le Bizec, Bruno
Source:
Molecular nutrition & food research 2008 v.52 no.2 pp. 258-265
ISSN:
1613-4125
Subject:
umbilical cord,   etc   ; flame retardants; lipids; neonates; risk; mothers; women; data collection; volunteers; health effects assessments; metabolism; humans; adipose tissue; fires; exposure assessment; pollutants; fetus; statistical analysis; breast milk; multiresidue analysis; France;     Show all 21 Subjects
Abstract:
... Brominated flame retardants (BFR) are chemicals extensively used in many manufactured products to reduce the risk of fire, but also environmental pollutants. In order to assess the potential risk linked to these compounds in human, a French monitoring study was initiated to evaluate the exposure of fetus and newborn. A previously described multi-residue analytical method was used, for measuring th ...
DOI:
10.1002/mnfr.200700077
PubMed:
18186099