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1. "Affinity-proteomics": direct protein identification from biological material using mass spectrometric epitope mapping

Author:
Marcus Macht; Andreas Marquardt; Sören-Oliver Deininger; Eugen Damoc; Markus Kohlmann; Michael Przybylski
Source:
Analytical and bioanalytical chemistry 2004 v.378 no.4 pp. 1102-1111
ISSN:
1618-2642
Subject:
binding proteins; cattle; databases; dissociation; epitope mapping; epitopes; excision; humans; mass spectrometry; monoclonal antibodies; muscle protein; myocardial infarction; myocardium; peptide mapping; peptides; proteolysis; troponin T
Abstract:
... We describe here a new approach for the identification of affinity-bound proteins by proteolytic generation and mass spectrometric analysis of their antibody bound epitope peptides (epitope excision). The cardiac muscle protein troponin T was chosen as a protein antigen because of its diagnostic importance in myocardial infarct, and its previously characterised epitope structure. Two monoclonal an ...
DOI:
10.1007/s00216-003-2159-8

2. "Best Friends" Sharing the HMGA1 Gene: Comparison of the Human and Canine HMGA1 to Orthologous Other Species

Author:
Murua Escobar, H.; Soller, J. T.; Richter, A.; Meyer, B.; Winkler, S.; Bullerdiek, J.; Nolte, I.
Source:
Journal of heredity 2005 v.96 no.7 pp. 777-781
ISSN:
0022-1503
Subject:
fluorescence in situ hybridization; messenger RNA; alternative splicing; humans; complementary DNA; sequence alignment; dogs; single nucleotide polymorphism; amino acid sequences; gene expression; genes; nucleotide sequences; chromatin; sequence homology; physical chromosome mapping; dog breeds
Abstract:
... HMGA1 nonhistone proteins are reported to participate in various cellular processes including regulation of inducible gene transcription, integration of retroviruses into chromosomes, and the induction of neoplastic transformation and promotion of metastatic progression of cancer cells. Overexpression of HMGA1 was shown to be characteristic for various malignant tumors, suggesting a relation betwe ...
DOI:
10.1093/jhered/esi083
PubMed:
15958792

3. "Green farming" - a set of technologies of the future

Author:
E.M. Gusev
Source:
BIO web of conferences 2021 v.36 pp. 07003
ISSN:
2117-4458
Subject:
developmental stages; economic feasibility; entropy; evaporation; humans; irrigation; soil compaction; soil erosion; tillage
Abstract:
... The purpose of the work was to demonstrate the evolution of agricultural technologies, which leads to the orientation of agriculture towards the use of nature-like farming, using the example of the human civilization development. It was shown that in the XX century, the stage of development of soil cultivation technologies, associated with the transition from "gray" extensive technologies for mana ...
DOI:
10.1051/bioconf/20213607003

4. "MALDI-CSI": A proposed method for the tandem detection of human blood and DNA typing from enhanced fingermarks

Author:
Katie Kennedy; Ravell Bengiat; Cameron Heaton; Yael Herman; Carla Oz; Michal Levin Elad; Laura Cole; Simona Francese
Source:
Forensic science international 2021 v.323 pp. 110774
ISSN:
0379-0738
Subject:
DNA; blood; desorption; digestion; forensic sciences; hemoglobin; humans; mass spectrometry; peptides; proteomics
Abstract:
... Matrix Assisted Laser Desorption Ionization Mass Spectrometry Profiling and Imaging (MALDI MSP and MALDI MSI), in combination with bottom up proteomics, have proven to successfully detect and map blood-derived peptide signatures in blood fingermarks, with high specificity and compatibility with a number of blood enhancement techniques (BET). In the present study, the application of MALDI MSP and M ...
DOI:
10.1016/j.forsciint.2021.110774

5. "Metal elements and pesticides as risk factors for Parkinson's disease - A review"

Author:
Inam Ullah; Longhe Zhao; Yang Hai; Muhammad Fahim; Dhafer Alwayli; Xin Wang; Hongyu Li
Source:
Toxicology reports 2021 v.8 pp. 607-616
ISSN:
2214-7500
Subject:
Parkinson disease; aluminum; homeostasis; humans; manganese; mercury; microRNA; neurotoxicity; pathogenesis; pesticides; toxicology
Abstract:
... Essential metals including iron (Fe) and manganese (Mn) with known physiological functions in human body play an important role in cell homeostasis. Excessive exposure to these essential as well as non-essential metals including mercury (Hg) and Aluminum (Al) may contribute to pathological conditions, including PD. Each metal could be toxic through specific pathways. Epidemiological evidences from ...
DOI:
10.1016/j.toxrep.2021.03.009

6. "Real-time" obstacle avoidance in the absence of primary visual cortex

Author:
Striemer, Christopher L.; Chapman, Craig S.; Goodale, Melvyn A.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.37 pp. 15996-16001
ISSN:
0027-8424
Subject:
brain; cortex; humans; vision
Abstract:
... When we reach toward objects, we easily avoid potential obstacles located in the workspace. Previous studies suggest that obstacle avoidance relies on mechanisms in the dorsal visual stream in the posterior parietal cortex. One fundamental question that remains unanswered is where the visual inputs to these dorsal-stream mechanisms are coming from. Here, we provide compelling evidence that these m ...
DOI:
10.1073/pnas.0905549106
PubMed:
19805240
PubMed Central:
PMC2747232

7. "Who" Is Saying "What"? Brain-Based Decoding of Human Voice and Speech

Author:
Formisano, Elia; De Martino, Federico; Bonte, Milene; Goebel, Rainer
Source:
Science 2008 v.322 no.5903 pp. 970-973
ISSN:
0036-8075
Subject:
acoustics; algorithms; brain; cortex; humans; magnetic resonance imaging; speech
Abstract:
... Can we decipher speech content ("what" is being said) and speaker identity ("who" is saying it) from observations of brain activity of a listener? Here, we combine functional magnetic resonance imaging with a data-mining algorithm and retrieve what and whom a person is listening to from the neural fingerprints that speech and voice signals elicit in the listener's auditory cortex. These cortical f ...
DOI:
10.1126/science.1164318

8. β-glucans and their significance for the preparation of functional foods – a review

Author:
M. Havrlentová; Z. Petruláková; A. Burgárová; F. Gago; A. Hlinková; E. Šturdík
Source:
Czech Journal of Food Sciences v.29 no.1 pp. 1-14
ISSN:
1805-9317
Subject:
barley; cardiovascular system; humans
Abstract:
... Cereals are generally known to have a positive influence on the general state of the human organism. The attention of the nutritional experts is paid especially to oats and barley. Besides their accessibility, these cereals are interesting due to their relatively high contents of soluble non-starch polysaccharides (fibrous material), out of which β-glucans have a dominant position from the as ...
DOI:
10.17221/162/2009-cjfs

9.  Animal welfare in the newborn piglet: a review

Author:
D. Mota-Rojas; J. Martinez-Burnes; D. Villanueva-Garcia; P. Roldan-Santiago; ME Trujillo-Ortega; H. Orozco-Gregorio; H. Bonilla-Jaime; A. Lopez-Mayagoitia
Source:
Veterinární medicína v.57 no.7 pp. 338-349
ISSN:
0375-8427
Subject:
acid-base balance; animal welfare; bicarbonates; blood; calcium; gas exchange; humans; lactic acid; muscles; necropsy; neonatal mortality; neonates; parturition; piglets; prognosis; umbilical cord; viability
Abstract:
... The objective of this review is to integrate clinical findings and laboratory analyses in such a way to improve the welfare of newborn piglets and achieve better prognoses of neonatal viability. Deaths during the intrapartum period account for a significant proportion of pre-weaning mortality in farms worldwide. Piglets which die during parturition generally have normal size and typically lack gro ...
DOI:
10.17221/6262-vetmed

10.  Cardiac manifestations of borreliosis in a dog: a case report

Author:
CF Agudelo; P. Schanilec; K. Kybicova; P. Kohout
Source:
Veterinární medicína v.56 no.2 pp. 85-92
ISSN:
0375-8427
Subject:
Borrelia burgdorferi; Lyme disease; antibodies; arrhythmia; cardiomyopathy; case studies; dogs; echocardiography; electrocardiography; humans; myocarditis; nervous system; pericarditis; Europe
Abstract:
... In Europe Lyme disease is caused by the spirochete Borrelia burgdorferi sensu lato. It presents with a variety of clinical manifestations including heart disease and problems of the nervous system, skin and joints. Lyme carditis occurs in 4–10% of infected humans and is characterized by a plethora of cardiovascular syndromes such as arrhythmia, myocarditis, and pericarditis among others. Thi ...
DOI:
10.17221/1577-vetmed

11.  Determination of fluoride in plant material using microwave induced  oxygen combustion

Author:
E. Šucman; J. Bednář
Source:
Czech Journal of Food Sciences v.30 no.5 pp. 438-441
ISSN:
1805-9317
Subject:
absorption; animal nutrition; combustion; diet; fluorides; fluorine; humans; oxygen; specific ion electrodes; standard deviation; tea
Abstract:
... Fluorine is essential in human and/or animal nutrition, thus it is important to know its concentration in a diet. One of the important sources of fluorine for humans is tea, containing relatively high amounts of this trace element. A method for fluoride determination in various kinds of tea using microwave supported sample preparation in a high pressure oxygen atmosphere followed by potentiometry ...
DOI:
10.17221/480/2011-cjfs

12.  Molecular mechanisms of ceftazidime resistance in Pseudomonas aeruginosa isolates from canine and human infections

Author:
S-J Du; H-C Kuo; C-H Cheng; ACY Fei; H-W Wei; S-K Chang
Source:
Veterinární medicína v.55 no.4 pp. 172-182
ISSN:
0375-8427
Subject:
Pseudomonas aeruginosa; blood flow; ceftazidime; dogs; humans; intergenic DNA; multiple drug resistance; otitis; patients; point mutation
Abstract:
... Sixty-six clinical P. aeruginosa isolates, 17 obtained from canine otitis specimens and 49 received from human patients with bloodstream infections, were collected between February 2007 and January 2008. The minimal inhibitory concentrations (MICs) of the antimicrobial agents of these isolates were determined. Multidrug resistance was common, with 23 (34.8%) isolates found to be ceftazidime resist ...
DOI:
10.17221/64/2010-vetmed

13.  Prevalence of Linguatula serrata infection among dogs (definitive host) and domestic ruminants (intermediate host) in the North West of Iran

Author:
F. Rezaei; M. Tavassoli; A. Mahmoudian
Source:
Veterinární medicína v.56 no.11 pp. 561-567
ISSN:
0375-8427
Subject:
cattle; definitive hosts; dogs; humans; intermediate hosts; lymph; parasites; respiratory system; risk; sheep; surveys; zoonoses; Iran
Abstract:
...  Linguatula serrata is a zoonotic parasite causing visceral and nasopharyngeal linguatulosis in humans. Dog and other canines are the main definitive hosts while most herbivores, including ruminants serve as intermediate hosts for linguatulosis. Human rarely become infected as both final and intermediate hosts. This survey aimed to assess the L. serrata infection rate of dogs and domestic rum ...
DOI:
10.17221/4275-vetmed

14.  Reference data of clinical chemistry, haematology and blood  coagulation parameters in juvenile cynomolgus monkeys (Macaca fascicularis)

Author:
H. Wang; YY Niu; W. Si; YJ Li; Y. Yan
Source:
Veterinární medicína v.57 no.5 pp. 233-238
ISSN:
0375-8427
Subject:
Macaca fascicularis; blood; blood chemistry; blood coagulation; chemistry; humans; juveniles; therapeutics
Abstract:
... Juvenile cynomolgus monkeys are valuable models for studying human diseases. Reference data of clinical chemistry, haematology and blood coagulation parameters of juvenile cynomolgus monkeys are very important for clinical diagnosis and conducting research. In this study, 72 blood samples (obtained from 35 males and 37 females) and 20 blood samples (obtained from 10 males and 10 females) were used ...
DOI:
10.17221/5953-vetmed

15.  Research on Mycobacterium avium during the period 1995 to 2009

Author:
M. Kaevska; K. Hruska
Source:
Veterinární medicína v.55 no.10 pp. 473-482
ISSN:
0375-8427
Subject:
National Library of Medicine; humans; immunomodulators; paratuberculosis; risk
Abstract:
... Papers on Mycobacterium avium, published between 1995 and 2009 that are indexed in the databases Web of Science® (Thomson Reuters) and PubMed (U.S. National Library of Medicine) were analysed and 3377 papers, published by 11 197 authors from 2630 institution and 75 countries were compared. Mycobacterium avium is represented by four subspecies (M. avium subsp. avium, M. avium subsp. ...
DOI:
10.17221/2942-vetmed

16.  Single-domain antibody fragments derived from heavy-chain antibodies: a review

Author:
L. Eyer; K. Hruska
Source:
Veterinární medicína v.57 no.9 pp. 439-513
ISSN:
0375-8427
Subject:
Camelidae; Chondrichthyes; antibodies; databases; diagnostic techniques; human diseases; humans; molecular weight; therapeutics; water solubility
Abstract:
... Single-domain antibody (sdAb) fragments derived from heavy-chain antibodies of camelids and cartilaginous fish represent a new generation of therapeutic agents and immunoreagents. Due to their unique characteristics, such as low molecular weight, high physical-chemical stability, good water solubility, and the ability to bind antigens inaccessible to conventional antibodies, they could potentially ...
DOI:
10.17221/6336-vetmed

17. 'Chumanzee' evolution: the urge to diverge and merge

Author:
Todd R Disotell
Source:
Genome biology 2006 v.7 no.11 pp. 1225
ISSN:
1474-760X
Subject:
Pan troglodytes; evolution; genome; humans; molecular genetics
Abstract:
... A recent analysis of the human and chimpanzee genomes compared with portions of other primate genomes suggests that the divergence of the human and chimpanzee lineages beginning around 6 million years ago was not a simple clean split. ...
DOI:
10.1186/gb-2006-7-11-240
PubMed:
17129363
PubMed Central:
PMC1794591

18. 'Genome design' model and multicellular complexity: golden middle

Author:
Vinogradov, Alexander E.
Source:
Nucleic acids research 2006 v.34 no.20 pp. 5906-5914
ISSN:
0305-1048
Subject:
amino acids; essential genes; gene ontology; humans; introns; mathematical theory; models; nucleic acids; promoter regions; transcription (genetics); transcription factors
Abstract:
... Human tissue-specific genes were reported to be longer than housekeeping genes (both in coding and intronic parts). The competing neutralist and adaptationist models were proposed to explain this observation. Here I show that in human genome the longest are genes with the intermediate expression pattern. From the standpoint of information theory, the regulation of such genes should be most complex ...
DOI:
10.1093/nar/gkl773
PubMed:
17062620
PubMed Central:
PMC1635334

19. 'Green Care' in Poland - Application of Horticulture for Improvement of Human Life Quality and Environment Protection

Author:
M. J. Latkowska
Source:
Acta horticulturae 2015 v. no.1093 pp. 125-131
ISSN:
0567-7572
Subject:
biodiversity; case studies; farms; food processing; fruit growing; health services; homeless people; humans; nongovernmental organizations; organic production; people with disabilities; quality of life; therapeutics; vegetable growing; villages; Poland
Abstract:
... ‘Green care’ is a special form of application of horticulture and farming in therapy and social care for the disadvantaged people. The aim of the study was to characterize model pioneer ‘green care’ initiatives in Poland. Data collected during the study visits was used to elaborate case studies of five ‘care farms’. Centres studied differ in their area (from 4.5 ha to 1,900 ha), howeve ...
DOI:
10.17660/ActaHortic.2015.1093.13

20. 'Lake Gorgana' - A paleolake in the Lower Danube Valley revealed using multi-proxy and regionalisation approaches

Author:
Dirk Nowacki; Carolin Clara Marie Langan; Annette Kadereit; Anna Pint; Jürgen Wunderlich
Source:
Quaternary international 2019 v.511 pp. 107-123
ISSN:
1040-6182
Subject:
carbon; floodplains; human population; humans; isotopes; lakes; limnology; nitrogen; paleoclimatology; sediments
Abstract:
... Geoarchaeological research at the archaeological site of Mǎgura Gorgana should elucidate the environmental setting Neolithic and Copper Age communities were faced with, when they settled along the Lower Danube Valley, Romania. This should enable a better understanding of human-environment interactions, the natural preconditions of a trading network, as well as the living conditions of the human po ...
DOI:
10.1016/j.quaint.2018.09.021

21. 'LeishMan' topoisomerase I: an ideal chimera for unraveling the role of the small subunit of unusual bi-subunit topoisomerase I from Leishmania donovani

Author:
Ganguly, Agneyo; Das, Benu Brata; Sen, Nilkantha; Roy, Amit; Dasgupta, Somdeb Bose; Majumder, Hemanta K.
Source:
Nucleic acids research 2006 v.34 no.21 pp. 6286-6297
ISSN:
0305-1048
Subject:
DNA; DNA topoisomerase; Leishmania donovani; active sites; catalytic activity; chimerism; humans; tyrosine
Abstract:
... The active site tyrosine residue of all monomeric type IB topoisomerases resides in the C-terminal domain of the enzyme. Leishmania donovani, possesses unusual heterodimeric type IB topoisomerase. The small subunit harbors the catalytic tyrosine within the SKXXY motif. To explore the functional relationship between the two subunits, we have replaced the small subunit of L.donovani topoisomerase I ...
DOI:
10.1093/nar/gkl829
PubMed:
17098934
PubMed Central:
PMC1669778

22. 'Roid rage in rats? Testosterone effects on aggressive motivation, impulsivity and tyrosine hydroxylase

Author:
Ruth I. Wood; Abigail Armstrong; Vlad Fridkin; Vivek Shah; Allison Najafi; Michael Jakowec
Source:
Physiology & behavior 2013 v.110-111 pp. 6-12
ISSN:
0031-9384
Subject:
adolescents; aggression; body weight; brain; cages; cortex; food intake; humans; learning; motivation; pellets; perfluorocarbons; rats; steroids; testosterone; tyrosine
Abstract:
... In humans and animals, anabolic-androgenic steroids (AAS) increase aggression, but the underlying behavioral mechanisms are unclear. AAS may increase the motivation to fight. Alternatively, AAS may increase impulsive behavior, consistent with the popular image of 'roid rage. To test this, adolescent male rats were treated chronically with testosterone (7.5mg/kg) or vehicle and tested for aggressiv ...
DOI:
10.1016/j.physbeh.2012.12.005
PubMed:
23266798
PubMed Central:
PMC3615053

23. (+)- and (−)-Cajanusine, a Pair of New Enantiomeric Stilbene Dimers with a New Skeleton from the Leaves of Cajanus cajan

Author:
Li Xiao-Long; Zhao Bing-Xin; Huang Xiao-Jun; Zhang Dong-Mei; Jiang Ren-Wang; Li Ying-Jie; Jian Yu-Qing; Wang Ying; Li Yao-Lan; Ye Wen-Cai
Source:
Organic letters 2014 v.16 no.1 pp. 224-227
ISSN:
1523-7052
Subject:
Cajanus cajan; X-ray diffraction; chemical reactions; chemical structure; hepatoma; humans; leaves; neoplasm cells; organic compounds; spectroscopy
Abstract:
... A pair of new enantiomeric stilbene dimers, (+)- and (−)-cajanusine [(+)-1 and (−)-1], with a unique coupling pattern were isolated from the leaves of Cajanus cajan. Their structures including absolute configurations were elucidated on the basis of comprehensive spectroscopic and single-crystal X-ray diffraction analyses, as well as CD calculations. The plausible biogenetic pathway of 1 was also p ...
DOI:
10.1021/ol403211a

24. (+)-Cyanidan-3-ol inhibits epidermoid squamous cell carcinoma growth via inhibiting AKT/mTOR signaling through modulating CIP2A-PP2A axis

Author:
Jitender Monga; Sharad Kumar Suthar; Deepak Rohila; Alex Joseph; Chetan Singh Chauhan; Manu Sharma
Source:
Phytomedicine 2022 v.101 pp. 154116
ISSN:
0944-7113
Subject:
agar; apoptosis; cell cycle checkpoints; dephosphorylation; drug resistance; experimental design; flow cytometry; fluorescent antibody technique; histology; humans; models; molecular biology; papilloma; phytotherapy; quantitative polymerase chain reaction; skin (animal); skin neoplasms; squamous cell carcinoma; toxicity; xenotransplantation
Abstract:
... Background: Despite recent advances in the treatment of squamous cell skin cancer (SCSC), the disease persists, and treatment resistance develops. Thus, identifying new targets and developing new therapeutic approaches showing low vulnerability to drug resistance is highly needed. Purpose: This study aimed to reveal a novel targeted phytotherapeutic strategy for SCSC treatment alone or in combinat ...
DOI:
10.1016/j.phymed.2022.154116

25. (+)-N-Deoxymilitarinone A, a Neuritogenic Pyridone Alkaloid from the Insect Pathogenic Fungus Paecilomyces farinosus

Author:
Cheng, Y.; Schneider, B.; Riese, U.; Schubert, B.; Li, Z.; Hamburger, M.
Source:
Journal of natural products 2006 v.69 no.3 pp. 436-438
ISSN:
0163-3864
Subject:
alkaloids; humans; cytotoxicity; pyridines; entomopathogenic fungi; neurites; cultured cells; spectral analysis; Isaria farinosa; rats; medicinal properties; chemical structure
DOI:
10.1021/np050418g
PubMed:
16562854

26. (+)-Panduratin A induces PANC-1 human pancreatic cancer cell death preferentially under nutrient starvation by inhibiting PI3K/Akt/mTOR/autophagy signaling pathway

Author:
Sijia Sun; Min Jo Kim; Ashraf M. Omar; Nguyen Duy Phan; Suresh Awale
Source:
Phytomedicine plus 2021 v.1 no.4 pp. 100101
ISSN:
2667-0313
Subject:
active ingredients; antineoplastic agents; autophagy; cell movement; cell structures; cytotoxicity; drug development; humans; neoplasm cells; pancreatic neoplasms; starvation
Abstract:
... Human pancreatic cancer cells have an extreme tolerance to nutrition starvation, enabling them to survive in the hypovascular tumor microenvironment, a phenomenon also known as “austerity”. Discovery of agents that preferentially inhibit cancer cells’ tolerance to nutrition starvation is a unique anti-austerity strategy for the discovery of a new generation of anticancer agents. To discover potent ...
DOI:
10.1016/j.phyplu.2021.100101

27. (+)-Strebloside-Induced Cytotoxicity in Ovarian Cancer Cells Is Mediated through Cardiac Glycoside Signaling Networks

Author:
Chen Wei-Lun; Ren Yulin; Ren Jinhong; Erxleben Christian; Johnson Michael E.; Gentile Saverio; Kinghorn A. Douglas; Swanson Steven M.; Burdette Joanna E.
Source:
Journal of natural products 2017 v.80 no.3 pp. 659-669
ISSN:
1520-6025
Subject:
Streblus asper; adverse effects; anticarcinogenic activity; antineoplastic activity; antineoplastic agents; apoptosis; bark; cytotoxicity; digitoxin; digoxin; humans; in vitro studies; interphase; mitogen-activated protein kinase; molecular models; mutants; neoplasm cells; ouabain; ovarian neoplasms; transcription factor NF-kappa B; Vietnam
Abstract:
... (+)-Strebloside, a cardiac glycoside isolated from the stem bark of Streblus asper collected in Vietnam, has shown some potential for further investigation as an antineoplastic agent. A mechanistic study using an in vitro assay and molecular docking analysis indicated that (+)-strebloside binds and inhibits Na⁺/K⁺-ATPase in a similar manner to digitoxin. Inhibition of growth of different high-grad ...
DOI:
10.1021/acs.jnatprod.6b01150
PubMed:
28234008
PubMed Central:
PMC5768141

28. (+)-Vitisin A inhibits influenza A virus-induced RANTES production in A549 alveolar epithelial cells through interference with Akt and STAT1 phosphorylation

Author:
Huang, Y.L.; Loke, S.H.; Hsu, C.C.; Chiou, W.F.
Source:
Planta medica 2008 v.74 no.2 pp. 156-162
ISSN:
0032-0943
Subject:
phosphatidylinositol 3-kinase; protein kinases; stilbenes; humans; phytochemicals; Influenza A virus; epithelial cells; signal transduction; Vitis; cultured cells; protein phosphorylation; chemokines
DOI:
10.1055/s-2007-993786
PubMed:
18240103

29. (+)‐Catechin ameliorates diabetic nephropathy by trapping methylglyoxal in type 2 diabetic mice

Author:
Dina Zhu; Lei Wang; Qile Zhou; Shijun Yan; Zhi Li; Jun Sheng; Wensheng Zhang
Source:
Molecular nutrition & food research 2014 v.58 no.12 pp. 2249-2260
ISSN:
1613-4125
Subject:
advanced glycation end products; animal disease models; cell communication; diabetic nephropathy; dose response; glucose; glycolysis; humans; interleukin-1beta; kidneys; metabolites; mice; noninsulin-dependent diabetes mellitus; pathogenesis; tumor necrosis factor-alpha
Abstract:
... SCOPE: Accumulation of glycolytic metabolite methylglyoxal (MG) in diabetic kidney is thought to contribute to the pathogenesis of nephropathy, either as a direct toxin or as a precursor for advanced glycation end products (AGEs). Using (+)‐catechin (CE), a novel MG trapper, we investigated whether MG trapping is sufficient to prevent the progression of diabetic nephropathy in type 2 diabetic mice ...
DOI:
10.1002/mnfr.201400533

30. (-)-Asarinin inhibits mast cells activation as a Src family kinase inhibitor

Author:
Yajing Hou; Tian Hu; Di Wei; Jiapan Gao; Delu Che; Xiangjun Wang; Cheng Wang; Huaizhen He
Source:
international journal of biochemistry & cell biology 2020 v.121 pp. 105701
ISSN:
1357-2725
Subject:
allergic rhinitis; anaphylaxis; animal models; anti-allergic agents; calcium; histamine; humans; interleukin-4; lignans; mast cells; mechanism of action; nasal mucosa; phosphorylation; phosphotransferases (kinases); public health; secretion
Abstract:
... As one of the major global health issues, allergic disease represents a considerable burden both on individual patients and public health. (-)-Asarinin (Asa), a lignan isolated from the roots of Asiasari radix, was reported to be associated with anti-allergic effect, but its efficacy and mechanism of action remain unclear. This study investigated the inhibitory effect of Asa on allergic reaction a ...
DOI:
10.1016/j.biocel.2020.105701

31. (-)-Epicatechin and its metabolites prevent palmitate-induced NADPH oxidase upregulation, oxidative stress and insulin resistance in HepG2 cells

Author:
Eleonora Cremonini; Patricia I. Oteiza
Source:
Archives of biochemistry and biophysics 2018 v.646 pp. 55-63
ISSN:
0003-9861
Subject:
NAD(P)H oxidase (H2O2-forming); Western diets; animal models; carbohydrates; enzyme activity; enzyme inhibitors; human cell lines; humans; insulin; insulin resistance; lipids; liver; metabolites; mice; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; oxidative stress; palmitates; risk; vegetables
Abstract:
... While diets rich in fruit and vegetables can decrease the risk for type 2 diabetes (T2D), diets rich in fat and carbohydrates can increase it. The flavanol-3-ol (-)-epicatechin (EC) can improve insulin sensitivity both in humans and animal models of T2D. NADPH oxidases and oxidative stress can contribute to the development of insulin resistance. This study investigated the capacity of EC and EC me ...
DOI:
10.1016/j.abb.2018.03.027

32. (-)-Epicatechin improves insulin sensitivity in high fat diet-fed mice

Author:
Eleonora Cremonini; Ahmed Bettaieb; Fawaz G. Haj; Cesar G. Fraga; Patricia I. Oteiza
Source:
Archives of biochemistry and biophysics 2016 v.599 pp. 13-21
ISSN:
0003-9861
Subject:
blood glucose; foods; high fat diet; humans; insulin; insulin receptors; insulin resistance; laboratory animals; liver; mice; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; obesity; protein kinase C; protein-tyrosine-phosphatase; public health; tissues
Abstract:
... Obesity constitutes a major public health concern, being frequently associated with type 2 diabetes (T2D). Evidence from studies in humans and experimental animals suggest that consumption of the flavan-3-ol (-)-epicatechin (EC) and of EC-rich foods may improve insulin sensitivity. To further understand the potential benefits of dietary EC consumption on insulin resistance, this study investigated ...
DOI:
10.1016/j.abb.2016.03.006
PubMed:
26968772
PubMed Central:
PMC5523407

33. (-)-Epigallocatechin gallate enhances the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation

Author:
Sakurai, Naoko; Mochizuki, Kazuki; Kameji, Hiroyuki; Shimada, Masaya; Goda, Toshinao
Source:
Nutrition 2009 v.25 no.10 pp. 1047-1056
ISSN:
0899-9007
Subject:
epigallocatechin; gene expression; gene expression regulation; adipocytes; humans; insulin resistance; cell differentiation; cell culture; nutrition research
Abstract:
... Objective: (-)-Epigallocatechin gallate (EGCG) is thought to enhance insulin sensitivity in adipocytes, although doses used in in vitro experiments have been shown to promote apoptosis. To explore the effects of EGCG on insulin sensitivity in adipocytes, the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes were measured in response to low doses ...
DOI:
10.1016/j.nut.2009.02.012
PubMed:
19535224

34. (-)-Epigallocatechin-3-gallate interferes with mast cell adhesiveness, migration and its potential to recruit monocytes

Author:
Melgarejo, E.; Medina, M. A.; Sánchez-Jiménez, F.; Botana, L. M.; Domínguez, M.; Escribano, L.; Orfao, A.; Urdiales, J. L.
Source:
Cellular and molecular life sciences 2007 v.64 no.19-20 pp. 2690-2701
ISSN:
1420-682X
Subject:
adhesion; angiogenesis; chemokines; chemoprevention; complementary DNA; gene expression; genes; green tea; humans; integrins; mast cells; metastasis; monocytes
Abstract:
... Mast cells are multipotent effector cells of the immune system. They are able to induce and enhance angiogenesis via multiple pathways. (-)-Epigallocatechin-3-gallate (EGCG), a major component of green tea and a putative chemopreventive agent, was reported to inhibit tumor invasion and angiogenesis, processes that are essential for tumor growth and metastasis. Using the human mast cell line HMC-1 ...
DOI:
10.1007/s00018-007-7331-4

35. (-)-Epigallocatechin-3-gallate suppresses cigarette smoke-induced inflammation in human cardiomyocytes via ROS-mediated MAPK and NF-κB pathways

Author:
Yingmin Liang; Mary Sau Man Ip; Judith Choi Wo Mak
Source:
Phytomedicine 2019 v.58 pp. 152768
ISSN:
0944-7113
Subject:
Camellia sinensis; Western blotting; acetylcysteine; apoptosis; cardiomyocytes; cardioprotective agents; cardiovascular diseases; catechin; chemokines; cigarettes; enzyme-linked immunosorbent assay; epigallocatechin gallate; flow cytometry; green tea; humans; inflammation; interleukins; leaves; mitochondria; mitogen-activated protein kinase; oxidative stress; reactive oxygen species; smoking (habit); transcription factor NF-kappa B
Abstract:
... Cigarette smoking is the leading cause for the initiation and development of cardiovascular disease (CVD). Oxidative stress and inflammatory responses play important roles in the pathophysiological processes of smoking-induced cardiac injury. (-)-epigallocatechin-3-gallate (EGCG), the most abundant catechin in green tea, which is made from Camellia sinensis leaves, has been reported to possess pot ...
DOI:
10.1016/j.phymed.2018.11.028

36. (-)-Xanthienopyran, a new inhibitor of superoxide anion generation by activated neutrophils, and further constituents of the seeds of Xanthium strumarium

Author:
Lee, Chia-Lin; Huang, Po-Ching; Hsieh, Pei-Wen; Hwang, Tsong-Long; Hou, Yu-Yi; Chang, Fang-Rong; Wu, Yang-Chang
Source:
Planta medica 2008 v.74 no.10 pp. 1276-1279
ISSN:
0032-0943
Subject:
cytotoxins; Xanthium strumarium; seeds; humans; cytotoxicity; pyrans; medicinal plants; aldehydes; superoxide anion; neutrophils; cultured cells; spectral analysis; xanthine; chemical structure; Oriental traditional medicine; anticarcinogenic activity
DOI:
10.1055/s-2008-1081295

37. (--)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans

Author:
Schroeter, H.; Heiss, C.; Balzer, J.; Kleinbongard, P.; Keen, C.L.; Hollenberg, N.K.; Sies, H.; Kwik-Uribe, C.; Schmitz, H.H.; Kelm, M.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2006 v.103 no.4 pp. 1024-1029
ISSN:
0027-8424
Subject:
epicatechin; rabbits; nitric oxide synthase; nitric oxide; aorta; humans; flavonols; vasodilation; cocoa (beverage); blood plasma; medicinal properties; oral administration; metabolites
Abstract:
... Epidemiological and medical anthropological investigations suggest that flavanol-rich foods exert cardiovascular health benefits. Endothelial dysfunction, a prognostically relevant key event in atherosclerosis, is characterized by a decreased bioactivity of nitric oxide (NO) and impaired flow-mediated vasodilation (FMD). We show in healthy male adults that the ingestion of flavanol-rich cocoa was ...
DOI:
10.1073/pnas.0510168103
PubMed:
16418281
PubMed Central:
PMC1327732

38. (1→3)-β-d-Glucan inhibits a dual mechanism of peroxynitrite stroke

Author:
Joanna Saluk-Juszczak; Karolina Krolewska; Barbara Wachowicz
Source:
International journal of biological macromolecules 2011 v.48 no.3 pp. 488-494
ISSN:
0141-8130
Subject:
Saccharomyces cerevisiae; antioxidant activity; blood lipids; blood proteins; cell walls; humans; hydrogen peroxide; immune system; in vitro studies; lipid peroxidation; oxidants; oxidation; oxidative stress; stroke; toxicity; yeasts
Abstract:
... AIM: The antioxidative and antinitrative activities of (1→3)-β-d-glucan (1–4μg/ml) from the yeast cell walls of Saccharomyces cerevisiae in human plasma treated with strong oxidants – peroxynitrite (ONOO⁻) (0.1mM) and hydrogen peroxide (H₂O₂) (2mM) were studied in vitro. The main purpose of this study was to assess if (1→3)-β-d-glucan, a well known strong immunostimulatory agent, possesses a prote ...
DOI:
10.1016/j.ijbiomac.2011.01.010

39. (1→3)-β-d-Glucan reduces the damages caused by reactive oxygen species induced in human platelets by lipopolysaccharides

Author:
Joanna Saluk; Michał Bijak; Michał Błażej Ponczek; Paweł Nowak; Barbara Wachowicz
Source:
Carbohydrate polymers 2013 v.97 no.2 pp. 716-724
ISSN:
0144-8617
Subject:
septic shock; disseminated intravascular coagulation; lipopolysaccharides; humans; molecular models; reactive oxygen species; blood platelets; Saccharomyces cerevisiae; stroke; platelet activation; Pseudomonas aeruginosa; antioxidant activity; oxidative stress; Escherichia coli
Abstract:
... LPS (lipopolysaccharide) induces platelet activation and is a well-known fundamental agent of septic shock and disseminated intravascular coagulation (DIC). Biological activity of (1→3)-β-d-glucan is related due to its anti-inflammatory, antioxidant, and antitumor properties. We focus our attention on the (1→3)-β-d-glucan (antiplatelet) properties.The main purpose of our study was to evaluate the ...
DOI:
10.1016/j.carbpol.2013.05.054

40. (2,4-cis and trans)-gigantecinone and 4-deoxygigantecin, bioactive nonadjacent bis-tetrahydrofuran annonaceous acetogenins, from Goniothalamus giganteus

Author:
Alali, F.Q.; Zhang, Y.; Rogers, L.; McLaughlin, J.L.
Source:
Journal of natural products 1997 v.60 no.9 pp. 929-933
ISSN:
0163-3864
Subject:
Goniothalamus; medicinal plants; stems; bark; long chain fatty acids; spectral analysis; chemical structure; stereochemistry; antineoplastic agents; humans; adenocarcinoma; chemical constituents of plants; Thailand
DOI:
10.1021/np970211q
PubMed:
9322367

41. (24S)-Ergostane-3β,5α,6β-triol from Hedyotis chrysotricha with inhibitory activity on migration of SK-HEP-1 human hepatocarcinoma cells

Author:
Miao Ye; Jing-Jing Su; Shu-Ting Liu; Lei Cao; Juan Xiong; Yun Zhao; Hui Fan; Guo-Xun Yang; Gang Xia; Jin-Feng Hu
Source:
Natural product research 2013 v.27 no.12 pp. 1136-1140
ISSN:
1478-6427
Subject:
Hedyotis; antineoplastic agents; apoptosis; cytotoxicity; fractionation; humans; methanol; screening
Abstract:
... The methanol extract of the whole plant of Hedyotis chrysotricha demonstrated cytotoxicity against SK-HEP-1 human hepatocarcinoma cells in a primary screening for novel antitumour agents. Bioassay-guided fractionation and purification led to an active principle (24S)-ergostane-3β,5α,6β-triol (1) along with four inactive compounds (2–5). The in vitro transwell migration assay showed that compound 1 ...
DOI:
10.1080/14786419.2012.715290

42. (2S)-2′-Methoxykurarinone from Sophora flavescens Suppresses Cutaneous T Cell-Attracting Chemokine/CCL27 Expression Induced by Interleukin-β/Tumor Necrosis Factor-α via Heme Oxygenase-1 in Human Keratinocytes

Author:
Jeong, Seung-Il; Lee, Young-Eun; Jang, Seon Il
Source:
Journal of medicinal food 2010 v.13 no.5 pp. 1116-1124
ISSN:
1096-620X
Subject:
heme oxygenase (biliverdin-producing); humans; interleukins; oxidative stress; inflammation; reverse transcriptase polymerase chain reaction; Western blotting; enzyme-linked immunosorbent assay; tumor necrosis factor-alpha; carbon monoxide; atopic dermatitis; keratinocytes; antioxidant activity; chemokines; Sophora flavescens; contact dermatitis; small interfering RNA
Abstract:
... One of the CC chemokines, cutaneous T cell-attracting chemokine (CTACK/CCL27), is a skin-specific CC chemokine that is produced constitutively by keratinocytes and is highly up-regulated in inflammatory skin conditions such as atopic dermatitis and contact dermatitis. (2S)-2′-Methoxykurarinone (MOK) from Sophora flavescens has been demonstrated to have antioxidant effects. Heme oxygenase (HO)-1 ha ...
DOI:
10.1089/jmf.2009.1333

43. (3-Aminopropyl)-4-methylpiperazine End-capped Poly(1,4-butanediol diacrylate-co-4-amino-1-butanol)-based Multilayer Films for Gene Delivery

Author:
Li Cuicui; Tzeng Stephany Y.; Tellier Liane E.; Green Jordan J.
Source:
ACS Applied Materials & Interfaces 2013 v.5 no.13 pp. 5947-5953
ISSN:
1944-8252
Subject:
gene transfer; chemical elements; coatings; humans; cytotoxicity; DNA; cations; gene expression; biodegradability
Abstract:
... Biodegradable polyelectrolyte surfaces for gene delivery were created through electrospinning of biodegradable polycations combined with iterative solution-based multilayer coating. Poly(β-amino ester) (PBAE) poly(1,4-butanediol diacrylate-co-4-amino-1-butanol) end-capped with 1-(3-aminopropyl)-4-methylpiperazine was utilized because of its ability to electrostatically interact with anionic molecu ...
DOI:
10.1021/am402115v
PubMed:
23755861
PubMed Central:
PMC3838882

44. (3-Mercaptopropyl)triethoxysilane-Modified Reduced Graphene Oxide-Modified Polyurethane Yarn Enhanced by Epoxy/Thiol Reactions for Strain Sensors

Author:
Shichen Zhang; Yue Sun; Jiangtao Xu
Source:
ACS applied materials & interfaces 2021 v.13 no.29 pp. 34865-34876
ISSN:
1944-8252
Subject:
adhesion; chemical bonding; crosslinking; epoxides; graphene; graphene oxide; humans; polyurethanes; thiols
Abstract:
... In the current work, a method was proposed to fabricate strain-sensing yarns via epoxy/thiol reactions by a dip-coating method. Reduced graphene oxide (rGO) was modified with (3-mercaptopropyl)triethoxysilane, and polyurethane yarn was cross-linked with 3-glycidoxypropyltrimethoxysilane. The existence of thiol in modified rGO and epoxy in the cross-linked polyurethane yarn contributed to the forma ...
DOI:
10.1021/acsami.1c07620

45. (3′R)-hydroxytabernaelegantine C: A bisindole alkaloid with potent apoptosis inducing activity in colon (HCT116, SW620) and liver (HepG2) cancer cells

Author:
Angela Paterna; Sofia E. Gomes; Pedro M. Borralho; Silva Mulhovo; Cecília M.P. Rodrigues; Maria-José U. Ferreira
Source:
Journal of ethnopharmacology 2016 v.194 pp. 236-244
ISSN:
0378-8741
Subject:
NAD ADP-ribosyltransferase; Tabernaemontana; alkaloids; apoptosis; cell viability; colon; colorectal neoplasms; cytotoxicity; fibroblasts; flow cytometry; fluorouracil; fractionation; guavas; human cell lines; humans; inhibitory concentration 50; lactate dehydrogenase; liver; medicinal plants; methanol; neoplasm cells; nuclear magnetic resonance spectroscopy; pro-apoptotic proteins; roots; staining; traditional medicine; Africa
Abstract:
... Tabernaemontana elegans Stapf. (Apocynaceae) is a medicinal plant traditionally used in African countries to treat cancer.To discover new apoptosis inducing lead compounds from T. elegans and provide scientific validation of the ethnopharmacological use of this plant.Through fractionation, (3′R)-hydroxytaberanelegantine C (1), a vobasinyl-iboga bisindole alkaloid, was isolated from a cytotoxic alk ...
DOI:
10.1016/j.jep.2016.09.020

46. (9βH)- and 17-Nor-Pimaranes from Icacina oliviformis

Author:
Meng Sun; Brian Guo; Mingming Xu; Ming Zhao; Monday M. Onakpa; Zhenlong Wu; Joanna E. Burdette; Chun-Tao Che
Source:
Journal of natural products 2021 v.84 no.4 pp. 949-955
ISSN:
1520-6025
Subject:
Icacina; cytotoxicity; diterpenoids; humans; neoplasm cells
Abstract:
... Eleven pimarane-type diterpenoids were isolated from the tubers of Icacina oliviformis, including three new compounds, icacinlactone M (9), icacinlactone H 2-O-β-d-glucopyranoside (10), and icacinlactone N 3-O-β-d-glucopyranoside (11), together with an artifact of acrenol (8). Among the known structures, icacinlactone A (2), icacinlactone B (3), icacinlactone H (4), 12-hydroxyicacinlactone A (5), ...
DOI:
10.1021/acs.jnatprod.9b01131

47. (9βH)-Pimaranes and Derivatives from the Tuber of Icacina trichantha

Author:
Zhao Ming; Onakpa Monday M.; Santarsiero Bernard D.; Chen Wei-Lun; Szymulanska-Ramamurthy Karina M.; Swanson Steven M.; Burdette Joanna E.; Che Chun-Tao
Source:
Journal of natural products 2015 v.78 no.11 pp. 2731-2737
ISSN:
1520-6025
Subject:
Icacina; X-ray diffraction; anticarcinogenic activity; cytotoxicity; humans; inhibitory concentration 50; melanoma; spectroscopy; tubers
Abstract:
... New 17-nor-pimaranes (1, 2), (9βH)-pimaranes (3, 4), and 17-nor-(9βH)-pimarane (5) were isolated from the tuber of Icacina trichantha. The structures were elucidated based on spectroscopic and HRMS data. The absolute configurations of 3 and 5 were determined by single-crystal X-ray diffraction. Compound 5 possesses a unique 19,20-δ-lactone moiety. Compound 3 showed cytotoxicity against MDA-MB-435 ...
DOI:
10.1021/acs.jnatprod.5b00688
PubMed:
26523419
PubMed Central:
PMC4703074

48. (Anti)mutagenic and immunomodulatory properties of quercetin glycosides

Author:
Kateřina Valentová; Petr Šíma; Zuzana Rybková; Jiří Křížan; Kateřina Malachová; Vladimír Křen
Source:
Journal of the science of food and agriculture 2016 v.96 no.5 pp. 1492-1499
ISSN:
0022-5142
Subject:
Ames test; Salmonella Typhimurium; T-lymphocytes; cell proliferation; cytotoxicity; dietary supplements; digestive system; dose response; epithelium; humans; humoral immunity; hydrogen peroxide; immunomodulators; isoquercitrin; mice; mutagenesis; mutagenicity; plasmids; quercetin; rutin
Abstract:
... BACKGROUND: Quercetin‐3‐O‐β‐d‐glucopyranoside (isoquercitrin) and quercetin‐3‐O‐rutinoside (rutin) are common components of a normal human diet and are increasingly used in food supplements. Here their effect on mutagenesis and immunity is shown. RESULTS: The in vitro (anti)mutagenic potential was compared with that of quercetin using the Ames test in Salmonella typhimurium His⁻ strains TA100, TA9 ...
DOI:
10.1002/jsfa.7251

49. (Ascorb)ing Pb Neurotoxicity in the Developing Brain

Author:
Faraz Ahmad; Ping Liu
Source:
Antioxidants 2020 v.9 no.12 pp. -
ISSN:
2076-3921
Subject:
antioxidants; ascorbic acid; brain; children; homeostasis; humans; lead; lead poisoning; metal ions; neurotoxicity; nutrients; research; therapeutics; trajectories
Abstract:
... Lead (Pb) neurotoxicity is a major concern, particularly in children. Developmental exposure to Pb can alter neurodevelopmental trajectory and has permanent neuropathological consequences, including an increased vulnerability to further stressors. Ascorbic acid is among most researched antioxidant nutrients and has a special role in maintaining redox homeostasis in physiological and physio-patholo ...
DOI:
10.3390/antiox9121311

50. (Before and) After the Flood: A multiproxy approach to past floodplain usage in the middle Wadi el-Hasa, Jordan

Author:
Daniel A. Contreras; Vincent Robin; Regina Gonda; Rachel Hodara; Marta Dal Corso; Cheryl Makarewicz
Source:
Journal of arid environments 2014 v.110 pp. 30-43
ISSN:
0140-1963
Subject:
anthropogenic activities; dry environmental conditions; floodplains; floods; humans; landscapes; sediments; surveys; Jordan; Middle East
Abstract:
... Floodplains are an important feature of arid landscapes, enabling intensive agricultural activity by providing a locale with a consistent and largely predictable water source that is accessible without costly infrastructural modifications. Floodplain agriculture, although likely an important part of ancient agricultural systems in the Near East, is notoriously difficult to detect, as the dynamic e ...
DOI:
10.1016/j.jaridenv.2014.06.002