U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject term humans Remove constraint Subject term: humans
Start Over

Search

214,156  Search Results

« Previous | 1 - 50 of 214,156 |
Number of results to display per page

Search Results

1. Development of a three dimensional (3D) knitted scaffold for myocardial tissue engineering. Part I: mechanical performance of the knitted structures

Author:
Derya Haroglu
Source:
The journal of the Textile Institute 2025 v.113 no.5 pp. 882-894
ISSN:
1754-2340
Subject:
fabrics; humans; macropores; medicine; micropores; myocardium; polyethylene terephthalates
Abstract:
... The aim of this study was to design a knitted scaffold for myocardial tissue engineering applications. The textile structure of pile loop knit fabric (terry fabric) was selected as a three dimensional (3 D) scaffold. The candidate fabrics were knitted from textured polyethylene terephthalate (PET) yarns. Biocompatible porous structures were obtained and the mechanical properties of the fabrics wer ...
DOI:
10.1080/00405000.2021.1907989

2. Development of a three dimensional (3D) knitted scaffold for myocardial tissue engineering. Part II: biological performance of the knitted scaffolds

Author:
Derya Haroglu; Ahmet Eken; Zeynep Burçin Gönen; Dilek Bahar
Source:
The journal of the Textile Institute 2025 v.113 no.5 pp. 895-905
ISSN:
1754-2340
Subject:
adhesion; anisotropy; cell adhesion; cell lines; fabrics; fibronectins; humans; interleukin-11; medicine; mice; myoblasts; myocardial infarction; myocardium; polyethylene terephthalates; porosity; therapeutics
Abstract:
... Cardiac patch has been proposed as an alternative therapeutic tissue engineering strategy to treat damaged heart for patients who survive the acute myocardial infarction (MI). To that end, studies have focused on designing an ideal cardiac patch assisting myocardium to repair itself. The engineering of three dimensional (3 D) anisotropic knitted scaffolds could be an efficient and effective strate ...
DOI:
10.1080/00405000.2021.1907990

3. Alleviative effects of a novel strain Bacillus coagulans XY2 on copper-induced toxicity in zebrafish larvae

Author:
Fang Ai; Xuedi Huang; Yalan Wu; Chen Ji; Yufang Gao; Ting Yu; Fujie Yan
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 750-760
ISSN:
1001-0742
Subject:
Bacillus coagulans; Danio rerio; antioxidant activity; genes; human health; humans; inflammation; interleukin-10; intestines; metabolism; models; mortality; neutrophils; oxidative stress; pollutants; probiotics; toxicity; transcription (genetics); China
Abstract:
... Copper (Cu) is a kind of micronutrient element that is essential for human metabolism. However, it is also considered as an environmental pollutant which is toxic to organisms at a high concentration level. Probiotics, regarded as beneficial microorganisms for promoting human health, have functions of antioxidant capacity, immune-enhancing properties, intestinal barrier protection and regulation. ...
DOI:
10.1016/j.jes.2022.02.010

4. Assessment of risks, implications, and opportunities of waterborne neurotoxic pesticides

Author:
Delaram Dara; Andrei P. Drabovich
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 735-741
ISSN:
1001-0742
Subject:
bioaccumulation; biochemical compounds; biodegradation; bioremediation; chlorinated hydrocarbons; genetic engineering; humans; mice; nervous system; neurotoxicity; organophosphorus compounds; pyrethrins; synergism; therapeutics; viability; China
Abstract:
... Pesticides are a well-known family of chemicals that have contaminated water systems globally. Four common subfamilies of pesticides include organochlorines, organophosphates, pyrethroids, and carbamate insecticides which have been shown to adversely affect the human nervous system. Studies have shown a link between pesticide exposure and decreased viability, proliferation, migration, and differen ...
DOI:
10.1016/j.jes.2022.03.033

5. Environment and COVID-19 incidence: A critical review

Author:
Jiatong Han; Jie Yin; Xiaoxu Wu; Danyang Wang; Chenlu Li
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 933-951
ISSN:
1001-0742
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; air quality; humans; pandemic; public policy; socioeconomics; spatial variation; uncertainty; wildlife; China
Abstract:
... The coronavirus disease 2019 (COVID-19) pandemic is an unprecedented worldwide health crisis. Many previous research studies have found and investigated its links with one or some natural or human environmental factors. However, a review on the relationship between COVID-19 incidence and both the natural and human environment is still lacking. This review summarizes the inter-correlation between C ...
DOI:
10.1016/j.jes.2022.02.016

6. Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones: A cross-sectional study

Author:
Bing Yue; Shangyong Ning; Hongjian Miao; Congrong Fang; Jingguang Li; Lei Zhang; Yan Bao; Sai Fan; Yunfeng Zhao; Yongning Wu
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 641-649
ISSN:
1001-0742
Subject:
Bayesian theory; bisphenol A; bisphenol F; bisphenol S; blood serum; chemical species; confidence interval; cross-sectional studies; dose response; homeostasis; humans; metabolites; occupational exposure; perchlorates; phthalates; regression analysis; thiocyanates; thyroid function; triiodothyronine; China
Abstract:
... Exposure to endocrine disruptors (EDCs) could disrupt thyroid hormone homeostasis. However, human epidemiological studies reported inconsistent observations, and scarce information on the effect of a mixture of chemicals. The aim of the present study was to examine the associations of multiple chemicals with thyroid hormones among adults from China. We measured serum levels of thyroid hormones and ...
DOI:
10.1016/j.jes.2022.01.017

7. Occurrence, spatial distribution and ecological risks of antibiotics in soil in urban agglomeration

Author:
Min Li; Lei Yang; Haw Yen; Fangkai Zhao; Xinmiao Wang; Tianhui Zhou; Qingyu Feng; Liding Chen
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 678-690
ISSN:
1001-0742
Subject:
cropland; doxycycline; edaphic factors; environmental health; erythromycin; human health; humans; issues and policy; land use; orchards; organic fertilizers; pollution; risk; soil ecosystems; sulfamethoxazole; urbanization; wastewater irrigation; China
Abstract:
... Antibiotics in soil environment are regarded as emerging pollutants and have introduced increasing risks to soil ecosystem and human health in rapid urbanization areas. Identifying the occurrence and spatial variability of antibiotics in soils is an urgent issue in sustaining soil security. In this study, antibiotics in soils were investigated and analyzed in Beijing-Tianjin-Hebei urban agglomerat ...
DOI:
10.1016/j.jes.2022.03.029

8. Origins of black carbon from anthropogenic emissions and open biomass burning transported to Xishuangbanna, Southwest China

Author:
Xuyan Liu; Siwen Wang; Qianqian Zhang; Chunlai Jiang; Linlin Liang; Shihao Tang; Xingying Zhang; Xiuzhen Han; Lin Zhu
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 277-289
ISSN:
1001-0742
Subject:
aerosols; air quality; biomass; carbon; emissions factor; humans; China; India; Laos; Myanmar
Abstract:
... Black carbon (BC) has importance regarding aerosol composition, radiative balance, and human exposure. This study adopted a backward-trajectory approach to quantify the origins of BC from anthropogenic emissions (BCAn) and open biomass burning (BCBB) transported to Xishuangbanna in 2017. Haze months, between haze and clean months, and clean months in Xishuangbanna were defined according to daily P ...
DOI:
10.1016/j.jes.2021.12.020

9. Parental and transgenerational impairments of thyroid endocrine system in zebrafish by 2,4,6-tribromophenol

Author:
Yuxi Zhou; Juanjuan Fu; Min Wang; Yongyong Guo; Lihua Yang; Jian Han; Bingsheng Zhou
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 291-299
ISSN:
1001-0742
Subject:
Danio rerio; adults; bioaccumulation; brain; chemical analysis; flame retardants; histopathology; humans; liver; pollution; progeny; toxicity; transcription (genetics); China
Abstract:
... Many environmental contaminants could be transmitted from parents and generate impairments to their progeny. The 2,4,6-tribromophenol (TBP), a novel brominated flame retardant which has been frequently detected in various organisms, was supposed to be bioaccumulated and intergenerational transmitted in human beings. Previous studies revealed that TBP could disrupt thyroid endocrine system in zebra ...
DOI:
10.1016/j.jes.2021.09.022

10. The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells

Author:
Li Li; Lingyi Xi; Jin Wu; Zunquan Zhao; Youliang Chen; Weili Liu; Zhihui Pan; Mingzhu Liu; Danfeng Yang; Zhaoli Chen; Yanjun Fang
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 823-830
ISSN:
1001-0742
Subject:
DNA; Western blotting; apoptosis; autophagy; flame retardants; flow cytometry; humans; neurons; neurotoxicity; phosphates; phosphorylation; protective effect; rats; China
Abstract:
... Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a commonly used organophosphate-based flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy. However, its regulatory mechanism remains un ...
DOI:
10.1016/j.jes.2022.02.046

11. Zn2+ loading as a critical contributor to the circ_0008553-mediated oxidative stress and inflammation in response to PM2.5 exposures

Author:
Jingzhou Wang; Jianbo Jia; Dujia Wang; Xiujiao Pan; Haiyan Xiong; Chengjun Li; Yiguo Jiang; Bing Yan
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 451-461
ISSN:
1001-0742
Subject:
Internet; epithelium; humans; inflammation; microRNA; models; oxidative stress; particulates; synergism; China
Abstract:
... Inflammation is a major adverse outcome induced by inhaled particulate matter with a diameter of ≤ 2.5 μm (PM₂.₅), and a critical trigger of most PM₂.₅ exposure-associated diseases. However, the key molecular events regulating the PM₂.₅-induced airway inflammation are yet to be elucidated. Considering the critical role of circular RNAs (circRNAs) in regulating inflammation, we predicted 11 circRNA ...
DOI:
10.1016/j.jes.2021.11.015

12. (+)-Cyanidan-3-ol inhibits epidermoid squamous cell carcinoma growth via inhibiting AKT/mTOR signaling through modulating CIP2A-PP2A axis

Author:
Jitender Monga; Sharad Kumar Suthar; Deepak Rohila; Alex Joseph; Chetan Singh Chauhan; Manu Sharma
Source:
Phytomedicine 2022 v.101 pp. 154116
ISSN:
0944-7113
Subject:
agar; apoptosis; cell cycle checkpoints; dephosphorylation; drug resistance; experimental design; flow cytometry; fluorescent antibody technique; histology; humans; models; molecular biology; papilloma; phytotherapy; quantitative polymerase chain reaction; skin (animal); skin neoplasms; squamous cell carcinoma; toxicity; xenotransplantation
Abstract:
... Background: Despite recent advances in the treatment of squamous cell skin cancer (SCSC), the disease persists, and treatment resistance develops. Thus, identifying new targets and developing new therapeutic approaches showing low vulnerability to drug resistance is highly needed. Purpose: This study aimed to reveal a novel targeted phytotherapeutic strategy for SCSC treatment alone or in combinat ...
DOI:
10.1016/j.phymed.2022.154116

13. (−)-Agelasidine A Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Human Hepatocellular Carcinoma

Author:
I-Ta Lu; Shih-Chao Lin; Yi-Chia Chu; Ya Wen; You-Cheng Lin; Wen-Chien Cheng; Jyh-Horng Sheu; Chi-Chien Lin
Source:
Marine drugs 2022 v.20 no.2 pp. -
ISSN:
1660-3397
Subject:
Western blotting; antibacterial properties; apoptosis; caspases; cell viability; death domain receptors; endoplasmic reticulum; guanidines; hepatoma; humans; liver; membrane potential; methanol; mitochondria; mitochondrial membrane; sesquiterpenoids
Abstract:
... Liver cancers, such as hepatocellular carcinoma (HCC), are a highly prevalent cause of cancer-related deaths. Current treatments to combat liver cancer are limited. (−)-Agelasidine A, a compound isolated from the methanol extract of Agelasnakamurai, a sesquiterpene guanidine derived from sea sponge, has antibacterial activity. We demonstrated its anticancer capabilities by researching the associat ...
DOI:
10.3390/md20020109

14. 1-Back reinforcement matching and mismatching by pigeons: Implicit or explicit learning?

Author:
Thomas R. Zentall; Daniel N. Peng; Peyton M. Mueller
Source:
Behavioural processes 2022 v.195 pp. 104562
ISSN:
0376-6357
Subject:
animal suffering; artificial intelligence; classical conditioning; humans; learning; methodology; monkeys; pigeons
Abstract:
... In human learning a distinction has been made between implicit and explicit learning. Implicit learning is thought involve automatic processes of the kind involved in Pavlovian conditioning, while explicit learning is thought to involve conscious hypothesis testing and rule formation, in which the ability to report the rule used to learn the task is taken as evidence. Because non-verbal animals ca ...
DOI:
10.1016/j.beproc.2021.104562

15. 10 years and going strong? Coastal flood risk management in the wake of a major coastal event (the 2010 Xynthia storm, Charente Maritime, France)

Author:
Estelle Rouhaud; Jean-Paul Vanderlinden
Source:
Climate risk management 2022 v.35 pp. 100413
ISSN:
2212-0963
Subject:
climate; coasts; humans; risk; risk reduction; storms; France; Netherlands; Western European region
Abstract:
... 2020 marked the 10th anniversary of the Xynthia storm that hit Western Europe at the end of February 2010. In France it triggered an unprecedented coastal flooding event, with most human and material damage concentrated on the Atlantic coast in the Vendée and Charente Maritime region. A range of reforms and measures followed to manage the risk of coastal flooding at the local and national levels.  ...
DOI:
10.1016/j.crm.2022.100413

16. 12-Plex DiLeu Isobaric Labeling Enabled High-Throughput Investigation of Citrullination Alterations in the DNA Damage Response

Author:
Zihui Li; Bin Wang; Qinying Yu; Yatao Shi; Lingjun Li
Source:
Analytical chemistry 2022 v.94 no.7 pp. 3074-3081
ISSN:
1520-6882
Subject:
DNA damage; DNA repair; analytical chemistry; arginine; biotin; humans; leucine; mass spectrometry; pathogenesis; post-translational modification; quantitative analysis; thiols
Abstract:
... Protein citrullination is a key post-translational modification (PTM) that leads to the loss of positive charge on arginine and consequent protein structural and functional changes. Though it has been indicated to play critical roles in various physiological and pathological processes, effective analytical tools are largely limited due to a few challenges such as the small mass shift induced by th ...
DOI:
10.1021/acs.analchem.1c04073

17. 16S rRNA Metagenomics Data on the Bacterial Communities in Integrated Poultry-Fish Farm Ponds

Author:
Sunday B. Akinde; Folasade M. Adeyemi; Omotayo O. Oyedara; Temitope F. Ajani; Waidi F. Sule; Janet O. Olaitan; Bamidele A. Iwalokun; Olabisi O. Ojo
Source:
Data in Brief 2022 pp. 108269
ISSN:
2352-3409
Subject:
Actinobacteria; Bayesian theory; Cyanobacteria; Firmicutes; Proteobacteria; birds; data collection; databases; farms; fish; food safety; genes; humans; metagenomics; poultry; poultry manure; public health; taxonomy; Benin; Cameroon; Madagascar; Nigeria
Abstract:
... In an integrated poultry-fish (IPF) farming system, fish and bird are reared simultaneously. It is a common practice in Sub-Saharan Africa countries like Nigeria, Cameroon, Madagascar, and Benin, offering economic benefits to farmers and minimizing farm running costs. It seems like another way for farmers to manage poultry waste as it is a common practice in IPF farm settings to feed reared fishes ...
DOI:
10.1016/j.dib.2022.108269

18. 16S rRNA gene sequencing data of the upper respiratory tract microbiome in the SARS-CoV-2 infected patients

Author:
Julia Galeeva; Vladislav Babenko; Ramiz Bakhtyev; Vladimir Baklaushev; Larisa Balykova; Pavel Bashkirov; Julia Bespyatykh; Anna Blagonravova; Daria Boldyreva; Dmitry Fedorov; Ilshat Gafurov; Raushaniya Gaifullina; Elena Galova; Alina Gospodaryk; Elena Ilina; Konstantin Ivanov; Daria Kharlampieva; Polina Khromova; Ksenia Klimina; Konstantin Kolontarev; Nadezhda Kolyshkina; Andrey Koritsky; Vyacheslav Kuropatkin; Vasily Lazarev; Alexander Manolov; Valentin Manuvera; Daria Matyushkina; Maxim Morozov; Ekaterina Moskaleva; Varvara Musarova; Oleg Ogarkov; Elizaveta Orlova; Alexander Pavlenko; Alla Petrova; Natalia Pozhenko; Dmitry Pushkar; Alexander Rumyantsev; Sergey Rumyantsev; Vladimir Rumyantsev; Lyubov Rychkova; Alexander Samoilov; Irina Shirokova; Vyacheslav Sinkov; Svetlana Solovieva; Elizaveta Starikova; Polina Tikhonova; Galina Trifonova; Alexander Troitsky; Alexander Tulichev; Yuri Udalov; Anna Varizhuk; Alexander Vasiliev; Vladimir Veselovsky; Rinat Vereshchagin; Alexey Volnukhin; Gaukhar Yusubalieva; Vadim Govorun
Source:
Data in Brief 2022 v.40 pp. 107770
ISSN:
2352-3409
Subject:
COVID-19 infection; Russia; Severe acute respiratory syndrome coronavirus 2; chest; computed tomography; data collection; disease severity; genes; humans; immune system; lungs; microbial communities; microbiome; microorganisms; oxygen; pandemic; patients; respiratory rate
Abstract:
... The SARS-CoV-2 pandemic is a big challenge for humanity. The COVID-19 severity differs significantly from patient to patient, and it is important to study the factors protecting from severe forms of the disease. Respiratory microbiota may influence the patient's susceptibility to infection and disease severity due to its ability to modulate the immune system response of the host organism. This dat ...
DOI:
10.1016/j.dib.2021.107770

19. 17α-Estradiol, an ignored endogenous natural estrogen in human: Updated estrogen metabolism pathways and its environmental risk analysis

Author:
Zhao Tang; Ze-hua Liu; Hao Wang; Zhi Dang
Source:
Science of the total environment 2022 v.829 pp. 154693
ISSN:
0048-9697
Subject:
enantiomers; environment; estrogenic properties; estrogens; humans; metabolism; municipal wastewater; risk; risk analysis; surface water; urine
Abstract:
... E1 and E2 are considered as the parent natural estrogens (NEs) in human metabolism pathways of NEs, while the enantiomer of E2, αE2 was not included and ignored. In this study, αE2 along with the other eleven NEs with estrogenic activities were found in six healthy human urines with the total concentration levels of 62.9–99.3 μg/L. The concentration contributed ratios (CCRs) of αE2 to the total tw ...
DOI:
10.1016/j.scitotenv.2022.154693

20. 1H Nuclear Magnetic Resonance (NMR)-Based Metabolome Diversity of Seabuckthorn (H. rhamnoides L.) Berries Originating from Two Geographical Regions of Indian Himalayas

Author:
Sugandh Singh; Prakash Chand Sharma
Source:
Food analytical methods 2022 v.15 no.1 pp. 157-171
ISSN:
1936-9751
Subject:
Hippophae rhamnoides; beta-alanine; cosmetics; databases; dietary supplements; drugs; food safety; heat; humans; metabolites; metabolome; metabolomics; multivariate analysis; nuclear magnetic resonance spectroscopy; spermidine; Himalayan region; India
Abstract:
... A comprehensive analysis of crucial metabolites in seabuckthorn (Hippophae rhamnoides L.) was conducted by analyzing the methanolic extract of berries originating from 37 geographical sites of the Indian Himalayas by using ¹H NMR-based metabolome profiling. The concentration of 103 metabolites was annotated, of which two, spermidine and beta-alanine, were reported for the first time in higher conc ...
DOI:
10.1007/s12161-021-02100-6

21. 1′-Acetoxyeugenol Acetate Isolated from Thai Ginger Induces Apoptosis in Human Ovarian Cancer Cells by ROS Production via NADPH Oxidase

Author:
Ju-Yeon Choi; Na-Kyung Lee; Yi-Yue Wang; Joon-Pyo Hong; So Ri Son; Da-Hye Gu; Dae Sik Jang; Jung-Hye Choi
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
Alpinia galanga; NAD(P)H oxidase (H2O2-forming); acetates; apoptosis; cytotoxicity; ginger; humans; mitogen-activated protein kinase; ovarian neoplasms; reactive oxygen species
Abstract:
... The rhizomes of Alpinia galanga (Thai ginger) have been used extensively as a spice in Southeast Asian and Arabian cuisines and reported to possess a wide range of biological properties, such as antioxidant, antimicrobial, and antibacterial. However, the specific molecular and cellular mechanisms underlying the anti-tumor effects induced by Thai ginger and its corresponding active compounds have b ...
DOI:
10.3390/antiox11020293

22. 2, 3-Dimethylsuccinic acid and fulvic acid attenuate lead-induced oxidative misbalance in brain tissues of Nile tilapia Oreochromis niloticus

Author:
Wesam A. Neamatallah; Kadry M. Sadek; Yasser S. El-Sayed; Ebeed A. Saleh; Asmaa F. Khafaga
Source:
Environmental science and pollution research 2022 v.29 no.15 pp. 21998-22011
ISSN:
0944-1344
Subject:
NADP-glucose-6-phosphate dehydrogenase; Oreochromis niloticus; antioxidant activity; antioxidants; brain; catalase; dietary supplements; fish; fulvic acids; glucose 6-phosphate; glutathione; glutathione peroxidase; glutathione transferase; heavy metals; histology; histopathology; humans; immunotoxicity; lactate dehydrogenase; lead acetate; lethal concentration 50; lipids; liver; malondialdehyde; neuroprotective effect; neurotoxicity; oxidative stress; pollution; research; superoxide dismutase
Abstract:
... Lead has long been known as neurotoxic and immunotoxic heavy metal in human and animals including fish, whereas, 2, 3-dimethylsuccinic acid (DMSA) and fulvic acid (FA) are well-known biological chelators. The present investigation was carried out to assess the potential chelating and antioxidant effects of dietary supplementation with DMSA and FA against lead acetate (Pb)-induced oxidative stress ...
DOI:
10.1007/s11356-021-16359-z

23. 2-(2-phenylethyl)chromone-enriched extract of the resinous heartwood of Chinese agarwood (Aquilaria sinensis) protects against taurocholic acid-induced gastric epithelial cells apoptosis through Perk/eIF2α/CHOP pathway

Author:
Jiale Ma; Huixia Huo; Hang Zhang; Lingxiao Wang; Yingxin Meng; Fengyu Jin; Xinyu Wang; Yimu Zhao; Yunfang Zhao; Pengfei Tu; Yuelin Song; Jiao Zheng; Jun Li
Source:
Phytomedicine 2022 v.98 pp. 153935
ISSN:
0944-7113
Subject:
Aquilaria sinensis; apoptosis; bile; caspase-7; cell viability; death; endoplasmic reticulum; epithelial cells; gastric mucosa; gastritis; heartwood; humans; medicine; taurocholic acid; therapeutics; China
Abstract:
... Injury of gastric epithelial cells is one of the most important pathological features of bile reflux gastritis. Chinese agarwood (the resinous heartwood of Aquilaria sinensis) has been used to treat stomach problems for thousands of years in China. However, the pathological mechanism of epithelial cells death induced by bile acids and the therapeutic target of Chinese agarwood for improving bile r ...
DOI:
10.1016/j.phymed.2022.153935

24. 21st Century water withdrawal decoupling: A pathway to a more water-wise world?

Author:
Felix Dalstein; Asjad Naqvi
Source:
Water resources and economics 2022 v.38 pp. 100197
ISSN:
2212-4284
Subject:
climate; globalization; humans; income; issues and policy; population growth; socioeconomic development; sustainable development; water; water pollution
Abstract:
... Human demand for adequate water resources and supplies has been and will continue to be a fundamental issue in the 21st century due to rapid population growth, growing economies and globalization, and increasing water pollution, among others. Water withdrawals in regions which are already encountering scarcity will impose intensifying pressure on water resources locally and globally, threatening t ...
DOI:
10.1016/j.wre.2022.100197

25. 2d and 3d human induced pluripotent stem cell-based models to dissect primary cilium involvement during neocortical development

Author:
Boutaud Lucile; Michael Marie; Banal Céline; Calderon Damelys; Farcy Sarah; Pernelle Julie; Goudin Nicolas; Maillard Camille; Dimartino Clémantine; Deleschaux Cécile; Dupichaud Sébastien; Lebreton Corinne; Saunier Sophie; Attié-Bitach Tania; Bahi-Buisson Nadia; Lefort Nathalie; Thomas Sophie
Source:
Journal of visualized experiments 2022 no.181 pp. e62667
ISSN:
1940-087X
Subject:
biogenesis; centrioles; humans; organoids; quantitative analysis; spatial data
Abstract:
... Primary cilia (PC) are non-motile dynamic microtubule-based organelles that protrude from the surface of most mammalian cells. They emerge from the older centriole during the G1/G0 phase of the cell cycle, while they disassemble as the cells re-enter the cell cycle at the G2/M phase boundary. They function as signal hubs, by detecting and transducing extracellular signals crucial for many cell pro ...
DOI:
10.3791/62667

26. 2‐Hydroxy‐phytanoyl‐CoA lyase (AtHPCL) is involved in phytol metabolism in Arabidopsis

Author:
Wentao Yang; Philipp Gutbrod; Katharina Gutbrod; Helga Peisker; Xiaoning Song; Anna‐Lena Falz; Andreas J. Meyer; Peter Dörmann
Source:
plant journal 2022 v.109 no.5 pp. 1290-1304
ISSN:
0960-7412
Subject:
Arabidopsis; alcohols; catabolism; chlorophyll; enzymes; fatty acids; human nutrition; humans; isoprenoids; metabolites; peroxisomes; yeasts
Abstract:
... During chlorophyll degradation, large amounts of the isoprenoid alcohol phytol are released. The pathway of phytol catabolism has been studied in humans, because chlorophyll is part of the human diet, but little is known for plants. In humans, phytanoyl‐CoA derived from phytol is degraded via α‐oxidation by phytanoyl‐CoA hydroxylase (PAHX) and 2‐hydroxy‐phytanoyl‐CoA lyase (HPCL). Arabidopsis cont ...
DOI:
10.1111/tpj.15632

27. 3-Deoxy-D-arabino-heptulosonate 7-phosphate synthase as the gatekeeper of plant aromatic natural product biosynthesis

Author:
Ryo Yokoyama; Bailey Kleven; Anika Gupta; Yuer Wang; Hiroshi A. Maeda
Source:
Current opinion in plant biology 2022 v.67 pp. 102219
ISSN:
1369-5266
Subject:
biosynthesis; carbon metabolism; humans; phenylalanine; phytochemicals; plant physiology; shikimate pathway; society
Abstract:
... The shikimate pathway connects the central carbon metabolism with the biosynthesis of aromatic amino acids—l-tyrosine, l-phenylalanine, and l-tryptophan—which play indispensable roles as precursors of numerous aromatic phytochemicals. Despite the importance of the shikimate pathway-derived products for both plant physiology and human society, the regulatory mechanism of the shikimate pathway remai ...
DOI:
10.1016/j.pbi.2022.102219

28. 3-Formylindole-based chitosan Schiff base polymer: Antioxidant and in vitro cytotoxicity studies on THP-1 cells

Author:
M. Ameer Ali; Shazia Anjum Musthafa; Ganesh Munuswamy-Ramanujam; V. Jaisankar
Source:
Carbohydrate polymers 2022 v.290 pp. 119501
ISSN:
0144-8617
Subject:
Candida albicans; Escherichia coli; Staphylococcus aureus; antioxidant activity; biocompatible materials; cell viability; chitosan; cytotoxicity; flow cytometry; humans; imines; leukemia; monocytes; polymers; reactive oxygen species; schiff bases
Abstract:
... Two imine derivatives of chitosan (i-CTs), namely 2FCT and 5MCT, were synthesized by reacting chitosan (CT) with 2-(3-formyl-1H-indol-1yl)acetonitrile (2F), and 5-methoxyindole-3-carbaldehyde (5M), respectively. The antimicrobial evaluation of i-CTs exhibited stronger inhibition effect against Staphylococcus aureus, Escherichia coli and Candida albicans. The antioxidant activity of 2FCT and 5MCT s ...
DOI:
10.1016/j.carbpol.2022.119501

29. 3D Biofabrication of a Cardiac Tissue Construct for Sustained Longevity and Function

Author:
Matthew Alonzo; Raven El Khoury; Naveen Nagiah; Vikram Thakur; Munmun Chattopadhyay; Binata Joddar
Source:
ACS applied materials & interfaces 2022 v.14 no.19 pp. 21800-21813
ISSN:
1944-8252
Subject:
Fourier transform infrared spectroscopy; atrophy; biofabrication; biomarkers; cardiomyocytes; cardiovascular diseases; cell culture; cytotoxicity; drugs; electron microscopy; fibroblasts; flow cytometry; humans; hydrogels; longevity; microgravity; models; modulus of elasticity; organoids; physiology; reflectance; three-dimensional printing; viability
Abstract:
... In this study, we developed three-dimensional (3D) printed annular ring-like scaffolds of hydrogel (gelatin–alginate) constructs encapsulated with a mixture of human cardiac AC16 cardiomyocytes (CMs), fibroblasts (CFs), and microvascular endothelial cells (ECs) as cardiac organoid models in preparation for investigating the role of microgravity in cardiovascular disease initiation and development. ...
DOI:
10.1021/acsami.1c23883

30. 3D Printing Silk-Based Bioresorbable Piezoelectric Self-Adhesive Holey Structures for In Vivo Monitoring on Soft Tissues

Author:
Irene Chiesa; Carmelo De Maria; Maria Rachele Ceccarini; Lorenzo Mussolin; Riccardo Coletta; Antonino Morabito; Rodolfo Tonin; Martino Calamai; Amelia Morrone; Tommaso Beccari; Luca Valentini
Source:
ACS applied materials & interfaces 2022 v.14 no.17 pp. 19253-19264
ISSN:
1944-8252
Subject:
Castanea; animal models; biocompatibility; digestive tract; fibroins; humans; intestines; nanocomposites; polyphenols; three-dimensional printing
Abstract:
... Flexible and biocompatible adhesives with sensing capabilities can be integrated onto human body and organ surfaces, characterized by complex geometries, thus having the potential to sense their physiological stimuli offering monitoring and diagnosis of a wide spectrum of diseases. The challenges in this innovative field are the following: (i) the coupling method between the smart adhesive and the ...
DOI:
10.1021/acsami.2c04078

31. 3D Printing of Meat Following Supercritical Fluid Extraction

Author:
Abhilash Aditya; Namsoo Peter Kim
Source:
Foods 2022 v.11 no.4 pp. -
ISSN:
2304-8158
Subject:
COVID-19 infection; blood; cholesterol; color; freshness; humans; hygiene; meat; myoglobin; oxidation; processing time; supercritical fluid extraction; temperature; three-dimensional printing; weight loss; Texas
Abstract:
... With the spread of COVID-19, understanding the spread of food poisoning, managing food materials related to chronic diseases, food ingredients’ reliability, and non-face-to-face or untact delivery methods are rapidly emerging. A new field of meat research has been introduced for hygienic and healthy recipes to maintain freshness and control personalized ingredients using supercritical processes an ...
DOI:
10.3390/foods11040554

32. 3D Printing-Enabled In-Situ Orientation of BaTi₂O₅ Nanorods in β-PVDF for High-Efficiency Piezoelectric Energy Harvesters

Author:
Xingang Liu; Yinghao Shang; Jingfeng Liu; Zhuzhu Shao; Chuhong Zhang
Source:
ACS applied materials & interfaces 2022 v.14 no.11 pp. 13361-13368
ISSN:
1944-8252
Subject:
anisotropy; deformation; electricity; energy conversion; extrusion; fluorides; humans; nanorods
Abstract:
... Piezoelectric energy harvesters (PEHs) with a three-dimensional (3D) structure are arousing increasing interest because of the ability to efficiently convert mechanical energy into electricity catering for self-powered systems. Among them, 3D PEHs composed of 1–3-type piezoelectric composites which exploit one-dimensional (1D) piezoceramic fillers rather than conventional powders are particularly ...
DOI:
10.1021/acsami.2c00443

33. 3D direct printing of composite bone scaffolds containing polylactic acid and spray dried mesoporous bioactive glass-ceramic microparticles

Author:
Azadeh Saberi; Aliasghar Behnamghader; Behzad Aghabarari; Aliakbar Yousefi; Dorota Majda; Maria Victoria Martinez Huerta; Masoud Mozafari
Source:
International journal of biological macromolecules 2022 v.207 pp. 9-22
ISSN:
0141-8130
Subject:
apatite; bioactive properties; biocompatibility; biocompatible materials; biomineralization; bones; cell adhesion; compression strength; humans; polylactic acid; porosity; porous media; storage modulus; viability
Abstract:
... In this study, a three-dimensional composite scaffold is proposed consisting of polylactic acid and spray dried glass-ceramic microparticles (SGCMs). The compositional and structural characterization showed that the obtained spray dried powder formed as glass-ceramic (GC) with a completely interconnected porosity structure. Before direct printing of scaffolds, the rheological behavior of polylacti ...
DOI:
10.1016/j.ijbiomac.2022.02.067

34. 3D origami paper-based ratiometric fluorescent microfluidic device for visual point-of-care detection of alkaline phosphatase and butyrylcholinesterase

Author:
Yongfeng Zhu; Xia Tong; Qisheng Wei; Guihan Cai; Yuanxin Cao; Chaoying Tong; Shuyun Shi; Fang Wang
Source:
Biosensors & bioelectronics 2022 v.196 pp. 113691
ISSN:
0956-5663
Subject:
alkaline phosphatase; biomarkers; biosensors; blood serum; catalytic activity; cholinesterase; computer software; fluorescence; humans; mobile telephones; quantitative analysis; therapeutics
Abstract:
... On-site multiplex enzyme detection is crucial for diagnosis, therapeutics and prognostic. To date, it is still a daunting challenge to develop portable, low-cost, and efficient multi-enzyme detection methods. Herein, a novel sample-in-result-out platform integrating ratiometric fluorescent assays with 3D origami microfluidic paper-based device (μPAD) was developed for simultaneous visual point-of- ...
DOI:
10.1016/j.bios.2021.113691

35. 3D printing of biocompatible low molecular weight gels: Imbricated structures with sacrificial and persistent N-alkyl-d-galactonamides

Author:
Faniry Andriamiseza; Delphine Bordignon; Bruno Payré; Laurence Vaysse; Juliette Fitremann
Source:
Journal of colloid and interface science 2022 v.617 pp. 156-170
ISSN:
0021-9797
Subject:
cell culture; cell growth; dimethyl sulfoxide; humans; hydrogels; microstructure; molecular weight; solubility; solubilization; solvents; three-dimensional printing
Abstract:
... We have shown earlier that low molecular weight gels based on N-heptyl-d-galactonamide hydrogels can be 3D printed by solvent exchange, but they tend to dissolve in the printing bath. We wanted to explore the printing of less soluble N-alkyl-d-galactonamides with longer alkyl chains. Less soluble hydrogels could be good candidates as cell culture scaffolds. N-hexyl, N-octyl and N-nonyl-d-galactona ...
DOI:
10.1016/j.jcis.2022.02.076

36. 3D printing of polyurethane/nanocellulose shape memory composites with tunable glass transition temperature

Author:
Yufan Zhou; Feng Wang; Zhijie Yang; Xiangzhou Hu; Yu Pan; Yuan Lu; Man Jiang
Source:
Industrial crops and products 2022 v.182 pp. 114831
ISSN:
0926-6690
Subject:
biocompatible materials; body temperature; cellulose; glass transition temperature; humans; nanocrystals; polyurethanes; tensile strength; three-dimensional printing
Abstract:
... Shape memory polyurethane (SMPU) has been widely recognized as promising potential smart materials. While, porous SMPU presented imperfect shape memory and mechanical properties. In this work, nanocellulose was incorporated in SMPU to improve the comprehensive properties of the porous SMPU by 3D printing prototyping. The shape fixation ratio (Rf) and the shape recovery rate (Rᵣ) were improved to a ...
DOI:
10.1016/j.indcrop.2022.114831

37. 3D-printable chitosan/silk fibroin/cellulose nanoparticle scaffolds for bone regeneration via M2 macrophage polarization

Author:
Dinesh K. Patel; Sayan Deb Dutta; Jin Hexiu; Keya Ganguly; Ki-Taek Lim
Source:
Carbohydrate polymers 2022 v.281 pp. 119077
ISSN:
0144-8617
Subject:
animal models; biodegradability; biopolymers; cellulose; chitosan; fibroins; humans; hydrogels; macrophages; skull; spectroscopy
Abstract:
... Biopolymers-induced immune microenvironment exhibited prominent effects on bone regeneration. Osteo-immunomodulatory responses of cellulose nanoparticles incorporated chitosan hydrogel scaffolds have not yet been reported. The objective of this study was to monitor the synergistic effects of silk fibroin and cellulose nanoparticles on the immune-modulatory behavior of chitosan biopolymer scaffolds ...
DOI:
10.1016/j.carbpol.2021.119077

38. 3D-printed composite scaffold with anti-infection and osteogenesis potential against infected bone defects

Author:
Zewen Qiao; Wenping Zhang; Haifeng Jiang; Xiang Li; Weijun An; Haibo Yang
Source:
RSC advances 2022 v.12 no.18 pp. 11008-11020
ISSN:
2046-2069
Subject:
Neottia; absorption; adhesion; antibacterial properties; bone formation; bone marrow; histology; humans; mechanics; microparticles; orthopedics; rabbits; therapeutics
Abstract:
... In the field of orthopedics, an infected bone defect is a refractory disease accompanied by bone infection and defects as well as aggravated circulation. There are currently no personalized scaffolds that can treat bone infections using local stable and sustained-release antibiotics while providing mechanical support and bone induction to promote bone repair in the process of absorption in vivo. I ...
DOI:
10.1039/d2ra00214k

39. 3D-printed oxygen-releasing scaffolds improve bone regeneration in mice

Author:
Ashley L. Farris; Dennis Lambrechts; Yuxiao Zhou; Nicholas Y. Zhang; Naboneeta Sarkar; Megan C. Moorer; Alexandra N. Rindone; Ethan L. Nyberg; Alexander Perdomo-Pantoja; S.J. Burris; Kendall Free; Timothy F. Witham; Ryan C. Riddle; Warren L. Grayson
Source:
Biomaterials 2022 v.280 pp. 121318
ISSN:
0142-9612
Subject:
antioxidants; biocompatible materials; biodegradability; bone formation; bones; extracellular matrix; humans; hyperoxia; hypoxia; mice; osteopontin; oxygen; polyvinyl alcohol; therapeutics; tissue repair; toxicity
Abstract:
... Low oxygen (O₂) diffusion into large tissue engineered scaffolds hinders the therapeutic efficacy of transplanted cells. To overcome this, we previously studied hollow, hyperbarically-loaded microtanks (μtanks) to serve as O₂ reservoirs. To adapt these for bone regeneration, we fabricated biodegradable μtanks from polyvinyl alcohol and poly (lactic-co-glycolic acid) and embedded them to form 3D-pr ...
DOI:
10.1016/j.biomaterials.2021.121318

40. 3F-α-pyrrolydinovalerophenone (3F-α-PVP) in vitro human metabolism: Multiple in silico predictions to assist in LC-HRMS/MS analysis and targeted/untargeted data mining

Author:
Jeremy Carlier; Diletta Berardinelli; Eva Montanari; Ascanio Sirignano; Annagiulia Di Trana; Francesco P. Busardò
Source:
Journal of chromatography 2022 v.1193 pp. 123162
ISSN:
1570-0232
Subject:
biochemical pathways; biomarkers; cannabinoids; chromatography; computer simulation; forensic sciences; hepatocytes; humans; hydroxylation; metabolism; metabolites; pentanols; poisoning; toxicology; Sweden
Abstract:
... Synthetic cathinones (SCs) constitute a heterogenous class of new psychoactive substances (NPS), structurally related to cathinone. SCs represent the widest NPS class, second to synthetic cannabinoids, accounting for approximately 160 different analogues with substitution at the phenyl group, the amine group, or the alkyl chain. In 2020, α-pyrrolidonophenone analogues were the most trafficked SCs, ...
DOI:
10.1016/j.jchromb.2022.123162

41. 4-Nitropyrazolin-5-ones as Readily Available Fungicides of the Novel Structural Type for Crop Protection: Atom-Efficient Scalable Synthesis and Key Structural Features Responsible for Activity

Author:
Alexander S. Budnikov; Elena R. Lopat’eva; Igor B. Krylov; Oleg O. Segida; Andrey V. Lastovko; Alexey I. Ilovaisky; Gennady I. Nikishin; Alexey P. Glinushkin; Alexander O. Terent’ev
Source:
Journal of agricultural and food chemistry 2022 v.70 no.15 pp. 4572-4581
ISSN:
1520-5118
Subject:
Aspergillus niger; Bipolaris sorokiniana; Candida albicans; Fusarium oxysporum; Fusarium verticillioides; Sclerotinia sclerotiorum; Staphylococcus aureus; Thanatephorus cucumeris; Venturia inaequalis; antifungal properties; food chemistry; humans; kresoxim-methyl; medicine; mycelium; plant protection; pyrazolones
Abstract:
... The development of new types of fungicides for agriculture and medicine is highly desirable due to the uprising fungal resistance against commonly used compounds. Herein, 4-substituted-4-nitropyrazolin-5-ones (nitropyrazolones) were proposed as highly active fungicides of the novel structural type. The first scalable and practical method for the nitropyrazolone synthesis was proposed, which is ato ...
DOI:
10.1021/acs.jafc.1c07413

42. 40-years of Lake Urmia restoration research: Review, synthesis and next steps

Author:
Masoud Parsinejad; David E. Rosenberg; Yusuf Alizade Govarchin Ghale; Bahram Khazaei; Sarah E. Null; Omid Raja; Ammar Safaie; Somayeh Sima; Armin Sorooshian; Wayne A. Wurtsbaugh
Source:
Science of the total environment 2022 v.832 pp. 155055
ISSN:
0048-9697
Subject:
Artemia; climate; ecosystems; environment; evaporation; farmers; governance; human health; humans; hydrology; irrigated farming; lakes; migratory birds; salinity; society; stakeholders; temperature; Iran
Abstract:
... Public concern over environmental issues such as ecosystem degradation is high. However, restoring coupled human-natural systems requires integration across many science, technology, engineering, management, and governance topics that are presently fragmented. Here, we synthesized 544 peer-reviewed articles published through September 2020 on the desiccation and nascent recovery of Lake Urmia in n ...
DOI:
10.1016/j.scitotenv.2022.155055

43. 4′,7-Di-O-methylnaringenin (DMNG), a naringenin derivative, activates p53 signal pathway through down-regulating MDM2

Author:
Siyu Zhang; Yifan Wang; Yujie Sun; Guangjian Zhao; Juan Wang; Lu Liu; Fang Liu; Peng Wang; Ximing Xu
Source:
Journal of functional foods 2022 v.89 pp. 104962
ISSN:
1756-4646
Subject:
Citrus; apoptosis; cancer therapy; colorectal neoplasms; humans; naringenin; protein synthesis; signal transduction
Abstract:
... Naringenin, a citrus flavonoid that possessed various biological activities, had emerged as a potential therapeutic agent for the management of a variety of diseases, but naringenin derivatives’ application in cancer therapy and underlying mechanisms of action were not fully understood. Our recent work had shown that 4′,7-Di-O-methylnaringenin (DMNG) exerted its anti-colon cancer activity and the ...
DOI:
10.1016/j.jff.2022.104962

44. 5-Hydroxymethylfurfural Exerts Negative Effects on Gastric Mucosal Epithelial Cells by Inducing Oxidative Stress, Apoptosis, and Tight Junction Disruption

Author:
Yanting Qiu; Xiaorong Lin; Zhongzheng Chen; Bin Li; Yuanyuan Zhang
Source:
Journal of agricultural and food chemistry 2022 v.70 no.12 pp. 3852-3861
ISSN:
1520-5118
Subject:
acetylcysteine; apoptosis; byproducts; cell proliferation; death domain receptors; diet; food chemistry; gastric mucosa; genes; humans; hydroxymethylfurfural; mitochondria; occludins; oxidative stress; protein synthesis; reactive oxygen species; tight junctions; toxicity
Abstract:
... 5-Hydroxymethylfurfural (5-HMF) is a processing byproduct present in foods that are consumed daily by humans, and the diet is the principal route for human exposure to it. However, its adverse effects on gastric epithelial cells are not fully understood. Based on the half inhibitory concentration value, concentrations of HMF of 2, 4, 8, and 16 mM were selected for this study. After 5-HMF treatment ...
DOI:
10.1021/acs.jafc.2c00269

45. 6700 years of diatom changes related to land use and climatic fluctuations in the Lake Aydat catchment (Auvergne, France): Coupling with cyanobacteria akinetes, pollen and non-pollen palynomorphs data

Author:
Aude Beauger; Karen Serieyssol; Benjamin Legrand; Delphine Latour; Vincent Berthon; Marlène Lavrieux; Yannick Miras
Source:
Quaternary international 2022 pp. -
ISSN:
1040-6182
Subject:
Aulacoseira; Bacillariophyceae; Cannabis sativa; Cyanobacteria; Stephanodiscus; eutrophication; hemp; humans; lakes; land use; landscapes; livestock; plankton; pollen; tourism; water quality; watersheds; France
Abstract:
... Nowadays Lake Aydat is an important site for tourism activities but blooms of cyanobacteria induced some restriction for aquatic activities by humans and their livestock. Thus, it was important to understand the lake's history as it should help in the development of restoration strategies to improve water quality in the future. Lake Aydat had a complex history affected by climatic changes and huma ...
DOI:
10.1016/j.quaint.2022.01.013

46. 8-Geranyloxycarbostyril as a potent 15-LOX-1 inhibitor showed great anti-tumor effects against prostate cancer

Author:
Mehrdad Aghasizadeh; Tayebe Moghaddam; Ahmad Reza Bahrami; Hamid Sadeghian; Seyed Jamal Alavi; Maryam M. Matin
Source:
Life sciences 2022 v.293 pp. 120272
ISSN:
0024-3205
Subject:
apoptosis; cisplatin; cytotoxicity; flow cytometry; growth retardation; humans; prostatic neoplasms; quinolones; toxicity testing
Abstract:
... Carbostyrils are quinolone derivatives, with possible growth inhibition properties on cancer cells. Unlike many tumors, 15-Lipoxygenase-1 (15-LOX-1) is highly expressed in prostate cancer (PCa) cells and has oncogenic properties. Here, with the hypothesis that 6-, 7- and 8-geranyloxycarbostyril (GQ) have inhibitory properties on 15-LOX-1, their effects were assessed on PCa cells. Their cytotoxic e ...
DOI:
10.1016/j.lfs.2021.120272

47. 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats

Author:
Shu-Chieh Hu; Seonggi Min; Hyun-Ki Kang; Dong-Jin Yang; Mallikarjuna Basavarajappa; Sherry M. Lewis; Kelly J. Davis; Ralph E. Patton; Matthew S. Bryant; Estatira Sepehr; Raul Trbojevich; Mason G. Pearce; Michelle E. Bishop; Wei Ding; Robert H. Heflich; MacKean P. Maisha; Robert Felton; Susan Chemerynski; Steven B. Yee; Melis Coraggio; Hans Rosenfeldt; R. Philip Yeager; Paul C. Howard; Yunan Tang
Source:
Food and chemical toxicology 2022 v.160 pp. 112780
ISSN:
0278-6915
Subject:
DNA; aerosols; air; biomarkers; blood; body weight; bone marrow; breathing; carcinogenesis; carcinogenicity; cigarettes; comet assay; food consumption; genotoxicity; histopathology; humans; inhalation toxicity; lowest observed effect level; lungs; metabolites; mutagens; nitrosamines; no observed adverse effect level; nose; propylene glycol; urine
Abstract:
... 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the key tobacco-specific nitrosamines that plays an important role in human lung carcinogenesis. Repeated dose inhalation toxicity data on NNK, particularly relevant to cigarette smoking, however, is surprisingly limited. Hence, there is a lack of direct information available on the carcinogenic and potential non-carcinogenic effects o ...
DOI:
10.1016/j.fct.2021.112780

48. A 1,400-year eolian dust activity record from Lake Erhai in the northeastern Tibetan Plateau

Author:
Min Wang; Caiming Shen; Xudong Wu; Guangxin Liu; Jiaju Zhao; Qifa Sun; Hongbo Zheng; Xiangzhong Li
Source:
Catena 2022 v.212 pp. 106050
ISSN:
0341-8162
Subject:
basins; carbonates; catenas; climate; dust; human health; humans; lakes; oxygen; particle size distribution; riparian areas; rivers; satellites; sediments; Central Asia; China
Abstract:
... Dust raised from Arid Central Asia (ACA) affects the global climate, global biogeochemical cycles, and human health. Studies on the ACA dust activities thus are crucial for understanding dust forcing mechanisms and the mitigation of hazardous storms. Located at the downwind margin of the ACA, the Lake Qinghai basin is an ideal trap for dust activities documentation. However, isolating eolian dust ...
DOI:
10.1016/j.catena.2022.106050

49. A 12,000 kyr paleohydroclimate record in the southeastern, U.S.A based on deuterium from bat guano

Author:
Alexandra Tsalickis; Matthew N. Waters; Joshua W. Campbell
Source:
Environmental earth sciences 2022 v.81 no.5 pp. 148
ISSN:
1866-6280
Subject:
Chiroptera; Holocene epoch; Pleistocene epoch; animal manures; climate; climate change; deuterium; human population; humans; lakes; land use; paleoclimatology; paleoecology; pollen; population growth; sediments; vegetation; Alabama
Abstract:
... The southeastern United States endures environmental change from human population increase, climate change, and land-use alterations creating the need to understand baseline conditions and environmental patterns prior to human impacts. While paleoenvironmental data can be reconstructed from a variety of archives (e.g., lake sediments, tree rings, speleothems), some geographic areas contain fewer s ...
DOI:
10.1007/s12665-022-10234-x

50. A 12-bp indel in the 3’UTR of porcine CISH gene associated with Landrace piglet diarrhea score

Author:
Buyue Niu; Zhihua Chen; Diwen Yao; Mingxing Kou; Xiaowen Gao; Yuan Sun; Xiuqin Yang; Xibiao Wang; Shengwei Di; Jiancheng Cai; Dongchun Guo
Source:
Research in veterinary science 2022 v.146 pp. 53-59
ISSN:
0034-5288
Subject:
colon; computer simulation; cytokines; diarrhea; gene expression; genes; genotype; humans; ileum; landraces; luciferase; lungs; mutation; phenotype; piglets; plasmids; quantitative polymerase chain reaction; research; statistical analysis; veterinary medicine
Abstract:
... Variations in Cytokine inducible SH2-containing protein (CISH) gene influence human susceptibility to common infectious diseases, but little is known about CISH in swine. The objectives of this study were to 1) determine porcine CISH (pCISH) mRNA expression level in different tissues of piglets, 2) predict putative functional genetic variations within pCISH, 3) investigate the association between ...
DOI:
10.1016/j.rvsc.2022.03.012