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- Hoshii, Takayuki, et al. Show all 12 Authors
- Biochemical and biophysical research communications 2014 v.450 pp. 837-843
- binding proteins; cell cycle; gene expression regulation; genes; green fluorescent protein; guanosine triphosphate; humans; leukemia; messenger RNA; mice; models; patients; prognosis; stem cells
- ... Acute myeloid leukaemia (AML) is a heterogeneous neoplastic disorder in which a subset of cells function as leukaemia-initiating cells (LICs). In this study, we prospectively evaluated the leukaemia-initiating capacity of AML cells fractionated according to the expression of a nucleolar GTP binding protein, nucleostemin (NS). To monitor NS expression in living AML cells, we generated a mouse AML m ...
- Hoshii, Takayuki, et al. Show all 20 Authors
- Molecular cell 2013 v.51 pp. 618-631
- autophagy; binding capacity; biochemical pathways; carcinoma; human growth; humans; organelles; oxidative stress; phosphorylation; ubiquitin-protein ligase
- ... The Keap1-Nrf2 system and autophagy are both involved in the oxidative-stress response, metabolic pathways, and innate immunity, and dysregulation of these processes is associated with pathogenic processes. However, the interplay between these two pathways remains largely unknown. Here, we show that phosphorylation of the autophagy-adaptor protein p62 markedly increases p62’s binding affinity for ...