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- Winter, Rolf, et al. Show all 3 Authors
- Parasitology international 2012 v.61 no.2 pp. 369-371
- Ancylostoma ceylanicum; Echinostoma caproni; Fasciola hepatica; Garcinia mangostana; Heligmosomoides polygyrus; Schistosoma mansoni; Trichuris muris; adults; bioactive properties; dose response; drugs; helminthiasis; humans; inhibitory concentration 50; larvae; parasitology; pericarp; pharmacokinetics; xanthone
- ... Few anthelminthic drugs are available for human use despite the significant burden caused by helminth infections. We studied the activities of mangostin, a major bioactive xanthone isolated from the pericarp and fruit of Garcinia mangostana and of the synthetic derivative mangostin diacetate. Mangostin and mangostin diacetate lacked activity against the nematodes Heligmosomoides polygyrus (third-s ...
- Winter, Rolf, et al. Show all 6 Authors
- Experimental parasitology 2011 v.127 no.2 pp. 545-551
- Plasmodium falciparum; humans; multiple drug resistance; models; microsomes; mice; polyethylene glycol; structure-activity relationships; parasitology; rats; malaria; oral administration; quinolones; antimalarials
- ... Our prior work on tricyclic acridones combined with a desire to minimize the tricyclic system led to an interest in antimalarial quinolones and a reexamination of endochin, an experimental antimalarial from the 1940’s. In the present article, we show that endochin is unstable in the presence of murine, rat, and human microsomes which may explain its relatively poor antimalarial activity in mammali ...
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