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1. (−)-α-Bisabolol as a protective agent against epithelial renal cytotoxicity induced by amphotericin B

Author:
Emanuel Paula Magalhães; Brenna Pinheiro Silva; Natália Luna Aires; Lyanna Rodrigues Ribeiro; Arif Ali; Mariana Maciel Cavalcanti; João Victor Serra Nunes; Tiago Lima Sampaio; Ramon Róseo Paula Pessoa Bezerra de Menezes; Alice Maria Costa Martins
Source:
Life sciences 2022 v.291 pp. 120271
ISSN:
0024-3205
Subject:
amphotericin B; antioxidants; apoptosis; cell viability; cytotoxicity; epithelium; flow cytometry; fungi; inhibitory concentration 50; kidneys; membrane potential; mitochondria; models; necrosis; nephroprotective effect; nephrotoxicity; oxidative stress
Abstract:
... Amphotericin B (AmB), used for systemic fungal infections, has a limited clinical application because of its high nephrotoxicity. Natural antioxidant and anti-inflammatory substances have been widely studied for protection against drug-induced nephrotoxicity. α-Bisabolol (BIS) has demonstrated a nephroprotective effect on both in vitro and in vivo models. The aim of this work was to evaluate the e ...
DOI:
10.1016/j.lfs.2021.120271

2. 4-Hydroxycoumarin Effects on Both Cellular and Genetic Characteristics of Hepatocellular Carcinoma Cells

Author:
Çağri Öner; Dilara Soyergin; Ahmet Özyurt; Ertuğrul Çolak
Source:
Cytology and genetics 2022 v.56 no.3 pp. 292-300
ISSN:
0095-4527
Subject:
4-hydroxycoumarin; adhesion; gene expression; genes; hepatoma; inhibitory concentration 50; liver; therapeutics; viability
Abstract:
... 4-Hydroxycoumarin is an aromatic substance which is metabolized in liver and used as a therapeutic agent for various diseases. We aimed to determine the impact of 4-Hydroxycoumarin on HepG2 cells according to their viability, proliferation, adhesion and gene expression of cellular behavior parameters. Inhibitory concentration 50 (IC50) of 4-Hydroxycoumarin was detected on HepG2 cells. After determ ...
DOI:
10.3103/S0095452722030094

3. A CdSe/ZnS core/shell competitive quantum dot-based fluorescence-linked immunosorbent assay for the sensitive and accurate detection of aflatoxin B1 in corn sample

Author:
Yanbing Lv; Yifan Yang; Ruili Wu; Yanxia Xu; Jinjie Li; Ning Li; Huaibin Shen; Yujuan Chai; Lin Song Li
Source:
Journal of food measurement & characterization 2022 v.16 no.1 pp. 857-866
ISSN:
2193-4126
Subject:
aflatoxin B1; analytical kits; antibodies; chemical species; commercialization; corn; detection limit; enzyme-linked immunosorbent assay; food contamination; inhibitory concentration 50; measurement; metabolites; quantum dots; toxicity
Abstract:
... Aflatoxin B1 (AFB1), as the main metabolite, found in aflatoxin contaminated food is highly toxic and strictly controlled in many countries. Aiming to construct a simplified, highly sensitive, and accurate quantitative detection platform of AFB1 in ordinary conditions, a one-step competitive quantum dot-labeled immunosorbent assay (cQLISA) was developed using biocompatible CdSe/ZnS core/shell quan ...
DOI:
10.1007/s11694-021-01223-y

4. A H258Y mutation in subunit B of the succinate dehydrogenase complex of the spider mite Tetranychus urticae confers resistance to cyenopyrafen and pyflubumide, but likely reinforces cyflumetofen binding and toxicity

Author:
Christine Njiru; Corinna Saalwaechter; Oliver Gutbrod; Sven Geibel; Nicky Wybouw; Thomas Van Leeuwen
Source:
Insect biochemistry and molecular biology 2022 v.144 pp. 103761
ISSN:
0965-1748
Subject:
Tetranychus urticae; acaricides; cross resistance; cytochrome P-450; histidine; hydrogen bonding; hydrophobicity; inhibitory concentration 50; insect biochemistry; introgression; ligands; mechanism of action; metabolites; mites; mitochondria; molecular biology; succinate dehydrogenase (quinone); toxicity; ubiquinones
Abstract:
... Succinate dehydrogenase (SDH) inhibitors such as cyflumetofen, cyenopyrafen and pyflubumide, are selective acaricides that control plant-feeding spider mite pests. Resistance development to SDH inhibitors has been investigated in a limited number of populations of the spider mite Tetranychus urticae and is associated with cytochrome P450 based detoxification and target-site mutations such as I260 ...
DOI:
10.1016/j.ibmb.2022.103761

5. A novel flavonoid with antioxidant activity from Patrinia villosa (Thunb.) Juss

Author:
Yang-Cheng Liu; Nan Sui; Jia-Qi Wang; Xin Wang; Wei Liu; Zheng Xiang; Chang-Lan Chen
Source:
Natural product research 2022 v.36 no.12 pp. 2977-2983
ISSN:
1478-6427
Subject:
Patrinia villosa; antioxidant activity; antioxidants; flavonoids; gel chromatography; inhibitory concentration 50; medicinal plants; research
Abstract:
... Patrinia villosa (Thunb.) Juss (P. villosa), a perennial herb, is widely used as a medicinal plant in Chinese folk. This study aims to isolate and identify the chemical constituents from P. villosa and evaluate their antioxidant activity. Normal silica column chromatography, ODS silica column chromatography, Sephadex LH-20 column chromatography and semi-preparative HPLC methods were used to obtain ...
DOI:
10.1080/14786419.2021.1935931

6. A pair of homoisoflavonoid analogues (6-aldehydo-isoophiopogonanone A/6-aldehydo-isoophiopogonanone B) from Ophiopogon japonicus as a tyrosinase inhibitor: inhibitory activity, conformational change and mechanism

Author:
Liling Wang; Yuchuan Qin; Yanbin Wang; Bentong Liu; Yifeng Zhou
Source:
European food research & technology 2022 v.248 no.2 pp. 553-565
ISSN:
1438-2377
Subject:
Ophiopogon japonicus; aldehydes; catalytic activity; dietary supplements; fluorescence; food research; hydrogen; hydrophobic bonding; inhibitory concentration 50; oxygen; van der Waals forces
Abstract:
... In this research, the inhibition mechanism of a pairs of homoisoflavonoid analogues (6-aldehydo-isoophiopogonanone A (AIO-A) and 6-aldehydo-isoophiopogonanone B (AIO-B)) on tyrosinase (Tyr) was investigated by multi-spectroscopic techniques combined with molecular docking. The results demonstrated that AIO-A suppressed the activity of Tyr in a reversible competitive-inhibition with a half inhibito ...
DOI:
10.1007/s00217-021-03902-y

7. A single-chain variable fragment antibody exerts anti-nervous necrosis virus activity by irreversible binding

Author:
Siyou Huang; Yujia Wu; Lianpan Su; Taowen Su; Qiong Zhou; Jing Zhang; Zhiying Zhao; Shaoping Weng; Jianguo He; Junfeng Xie
Source:
Aquaculture 2022 v.552 pp. 738001
ISSN:
0044-8486
Subject:
Betanodavirus; Epinephelus coioides; antibodies; aquaculture; aquaculture industry; artificial insemination; coat proteins; decontamination; dissociation; grouper; immunity; inhibitory concentration 50; juveniles; mortality; necrosis; neutralization; salinity; seawater; serotypes; virion; viruses
Abstract:
... Nervous necrosis virus (NNV), causing almost 100% mortality among infected larvae and juvenile fish, is severely affecting the aquaculture industry. Although various vaccines against NNV were studied, they can hardly provoke strong enough immunity in fry with immature immune systems. To eliminate the infection possibility during fertilization, we applied an anti-NNV strategy by neutralization base ...
DOI:
10.1016/j.aquaculture.2022.738001

8. Abscisic acid and aloe-emodin against NS2B-NS3A protease of Japanese encephalitis virus

Author:
SaiPriyanka Bhimaneni; Anoop Kumar
Source:
Environmental science and pollution research 2022 v.29 no.6 pp. 8759-8766
ISSN:
0944-1344
Subject:
Japanese encephalitis virus; abscisic acid; encephalitis; inhibitory concentration 50; pollution; prediction; proteinase inhibitors; proteinases; research; toxicity
Abstract:
... There are no specific drugs for the treatment of Japanese Encephalitis. Thus, new chemical entities or exploration of existing molecules is required. We have tested the antiviral potential of abscisic acid and aloe-emodin against protease of the Japanese encephalitis virus (JEV) using the computational and target-based assay. Maestro Schrödinger glide suite 2019 was used for molecular docking and ...
DOI:
10.1007/s11356-021-16229-8

9. Ag NPs supported chitosan-agarose modified Fe3O4 nanocomposite catalyzed synthesis of indazolo[2,1-b]phthalazines and anticancer studies against liver and lung cancer cells

Author:
Yi Cai; Bikash Karmakar; Mohamed A. Salem; Abdullah Y. Alzahrani; Mutasem Z. Bani-Fwaz; Atif Abdulwahab A. Oyouni; Osama Al-Amer; Gaber El-Saber Batiha
Source:
International journal of biological macromolecules 2022 v.208 pp. 20-28
ISSN:
0141-8130
Subject:
antioxidant activity; antioxidants; catalysts; catalytic activity; cell lines; cell viability; cytotoxicity; drug therapy; drugs; filtration; hepatoma; inhibitory concentration 50; liver; lung neoplasms; lungs; nanocomposites; neoplasm cells
Abstract:
... In this article we report a novel Ag NPs fabricated chitosan-agarose composite functionalized core-shell type Fe₃O₄ nanoparticle (Ag/CS-Agar@Fe₃O₄). The biogenic material was analyzed over a number of physicochemical methods like, FT-IR, FE-SEM, TEM, EDX, XRD, VSM and ICP-OES. In catalytic exploration we aimed the synthesis of diverse 2H-indazolo0-b]phthalazine-trione derivatives via one-pot three ...
DOI:
10.1016/j.ijbiomac.2022.02.172

10. Amelioration Effects of Leaf Extract of Centella asiatica on Sodium Arsenate Induced Hepatotoxicity in Zebra Fish

Author:
Srinivasan Ragupathi; Anbarasi Gunasekar; Nayana Chathalingath; Tharangini priya Mohan
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
Centella asiatica; Danio rerio; antioxidants; arsenic; flavonoids; glycosides; hepatotoxicity; histology; histopathology; inhibitory concentration 50; leaf extracts; liver; phenolic compounds; pollutants; public health; sodium; sodium arsenate; terpenoids
Abstract:
... Arsenic contamination in drinking water is a major public health concern. It is classified as an environmental pollutant that necessitates immediate corrective action. Long-term arsenic exposure may cause hepatotoxicity. The current research focuses on the effectiveness of a methanolic extract of Centella asiatica against sodium arsenate-induced hepatotoxicity in Danio rerio (Zebrafish). Phytochem ...
DOI:
10.1016/j.sajb.2022.04.052

11. Anti-leishmanial activity of Avicennia marina (Avicenniaceae family) leaves hydroalcoholic extract and its possible cellular mechanisms

Author:
Zahra Rashno; Iraj Sharifi; Razieh Tavakoli Oliaee; Saeed Tajbakhsh; Fariba Sharififar; Fatemeh Sharifi; Abbas Hatami; Ashkan Faridi; Zahra Babaei
Source:
Parasite epidemiology and control 2022 v.17 pp. e00239
ISSN:
2405-6731
Subject:
Avicennia marina; Leishmania tropica; amastigotes; antileishmanial properties; antileishmanials; apoptosis; arginase; cutaneous leishmaniasis; cytotoxicity; dose response; epidemiology; indigenous species; inhibitory concentration 50; parasites; phytochemicals; promastigotes; reactive oxygen species; saponins
Abstract:
... Natural products are the main source of potent antioxidants and anti-leishmanial agents. This study was aimed to evaluate Avicennia marina (Avicenniaceae family) extract inhibitory effect against Leishmania tropica by accessing apoptotic markers and arginase activity. The A. marina were extracted and phytochemical analysis conducted. The inhibitory effect of A. marina was evaluated on L. tropica p ...
DOI:
10.1016/j.parepi.2022.e00239

12. Anti-respiratory syncytial virus and anti-herpes simplex virus activity of six Tanzanian medicinal plants with extended studies of Erythrina abyssinica stem bark

Author:
Jackson T. Mollel; Joanna S. Said; Rose J. Masalu; Charles Hannoun; Mourice V.N. Mbunde; Ramadhani S.O. Nondo; Tomas Bergström; Edward Trybala
Source:
Journal of ethnopharmacology 2022 v.292 pp. 115204
ISSN:
0378-8741
Subject:
Erythrina abyssinica; amino acids; antiviral agents; antiviral properties; bark; carbohydrate content; chromatography; ethanol; ethyl acetate; fractionation; hexane; ingredients; inhibitory concentration 50; molecular weight; pathogenicity; plant extracts; sialic acid; stop codon; surveys; traditional medicine; viruses; Tanzania
Abstract:
... Except for few highly pathogenic viruses, no antiviral drug has been approved for treatment of viral infections in humans. Plant extracts, selected based on their ethno-medical use, represent an important source of compounds for the development of novel candidate antiviral drugs. This especially concerns plants with ethnomedical records on their use in treatment of viral infections. To identify an ...
DOI:
10.1016/j.jep.2022.115204

13. Antibacterial activities of plant leaf extracts against multi-antibiotic resistant Staphylococcus aureus associated with skin and soft tissue infections

Author:
P. A. Akinduti; V. Emoh-Robinson; H. F. Obamoh-Triumphant; Y. D. Obafemi; T. T. Banjo
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 47
ISSN:
2662-7671
Subject:
Acalypha wilkesiana; Azadirachta indica; Moringa oleifera; Staphylococcus aureus; Vernonia amygdalina; adults; alternative medicine; antibiotic resistance; biofilm; chloramphenicol; ciprofloxacin; culture media; gentamicin; inhibitory concentration 50; leaves; multiple drug resistance; ofloxacin; phenotype; phytochemicals; saponins; terpenoids; tissues; vancomycin
Abstract:
... BACKGROUND: The antibacterial activities of aqueous leaf extracts of Moringa oleifera, Vernonia amygdalina, Azadirachta indica and Acalypha wilkesiana against multidrug resistance (MDR) Staphylococcus aureus associated with skin and soft tissue infections were investigated. METHODS: Staphylococcus aureus (n = 183) from the skin and soft tissue infections with evidence of purulent pus, effusions fr ...
DOI:
10.1186/s12906-022-03527-y

14. Antibacterial and antioxidant properties of Cichorium intybus extract embedded in chitosan nanocomposite nanofibers

Author:
Ahmed Emadelddin Mohamed; Amro Shetta; James Kegere; Wael Mamdouh
Source:
International journal of biological macromolecules 2022 v.215 pp. 387-397
ISSN:
0141-8130
Subject:
Cichorium intybus; Escherichia coli; antibiotics; antioxidant activity; antioxidants; chicory; chitosan; death; ethanol; freeze drying; gallic acid; inhibitory concentration 50; minimum inhibitory concentration; models; nanocomposites; nanofibers; polyvinyl alcohol; root extracts; solvents
Abstract:
... Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) bacteria acquired serious bacterial resistance against antibiotics. Untreated dangerous infections can cause death. We proposed nanofibers (NFs) of Polyvinyl alcohol (PVA)/Chitosan (CS) nanocomposite embedded with Chicory root extract (CRE) as a safe solution. We determined the best extraction solvent and drying method, 70 % ethanol ...
DOI:
10.1016/j.ijbiomac.2022.06.088

15. Anticancer activity and apoptotic induction of Chromolaena odorata Linn leaves extract and fractions on hepatocellular carcinoma cell lines (HepG2)

Author:
HANIFAH YUSUF; MARHAMI FAHRIANI
Source:
Jurnal Natural (Aceh) 2022 v.22 no.1 pp. 57-67
ISSN:
2541-4062
Subject:
Chromolaena odorata; alkaloids; antineoplastic activity; apoptosis; ethanol; ethyl acetate; flavonoids; hepatoma; hexane; inhibitory concentration 50; liquid chromatography; maceration; neoplasm cells; saponins
Abstract:
... The purpose of this study is to screen and to evaluate anticancer activity and apoptosis induction of Chromolaena odorata (C. odorata) leaves extract and its fractions on HepG2 cancer cell lines. The C. odorata leaves were extracted by maceration using ethanol 80% then fractionated by using n-hexane, ethyl acetate and ethanol. MTT assay method was used to evaluate anticancer activity and flowcytom ...
DOI:
10.24815/jn.v22i1.22854

16. Anticancer activity of N-heteroaryl acetic acid salts against breast cancer; in silico and in vitro investigation

Author:
Samaneh Zolghadri; Ali Ghanbariasad; Fatemeh Fallahian; Mahdie Rahban; Mahsa Kalavani; Enayatollah Bahman Jahromi; Azizeh Asadzadeh; Maliheh Hajiani
Source:
Molecular biology reports 2022 v.49 no.1 pp. 363-372
ISSN:
0301-4851
Subject:
acetic acid; antineoplastic activity; antineoplastic agents; apoptosis; breast neoplasms; cancer therapy; caspase-3; caspase-8; computer simulation; cytotoxicity; flow cytometry; gene expression; genes; histone deacetylase; inhibitory concentration 50; mechanism of action; molecular biology; neoplasm cells; quantitative polymerase chain reaction
Abstract:
... BACKGROUND: The present research was performed to assess N-heteroaryl acetic acid salts' anticancer activity against the breast cancer cell in order to introduce new inhibitory agents for histone deacetylase. METHODS AND RESULTS: A molecular docking simulation was performed to design the rational novel compounds. Afterward, the best compounds were selected for synthesis. The cytotoxic effects and ...
DOI:
10.1007/s11033-021-06881-1

17. Anticancer effect of marine bivalves derived polysaccharides against human cancer cells

Author:
Deepakrajasekar Padmanaban; Angeline Samuel; Gracy Jenifer Sahayanathan; Kavitha Raja; Arulvasu Chinnasamy
Source:
Biocatalysis and agricultural biotechnology 2022 v.39 pp. 102240
ISSN:
1878-8181
Subject:
Bivalvia; DNA fragmentation; acridine orange; agricultural biotechnology; antineoplastic activity; antineoplastic agents; apoptosis; biocatalysis; breasts; clinical examination; colon; cytotoxicity; enzymatic hydrolysis; ethidium; humans; inhibitory concentration 50; liver; marine environment; polypeptides; polysaccharides; propidium; rhodamines; therapeutics
Abstract:
... In recent decades, studies on cancer prophylactics and therapeutics with development of novel anticancer drugs have garnered interest on a global scale. The diverse marine environment is a major source of biocompounds and has been acknowledged as an important platform for drug discovery. A wide variety of novel agents in the form of protein, polysaccharide, polypeptide and steroid from marine micr ...
DOI:
10.1016/j.bcab.2021.102240

18. Anticancer effects of biosynthesized Cu2O nanoparticles using marine yeast

Author:
Amany A. Hassabo; Eman I. Ibrahim; Basant A. Ali; Hossam E. Emam
Source:
Biocatalysis and agricultural biotechnology 2022 v.39 pp. 102261
ISSN:
1878-8181
Subject:
Rhodotorula rubra; agricultural biotechnology; biocatalysis; biosynthesis; cancer therapy; cell growth; cell viability; colorectal neoplasms; copper nanoparticles; copper sulfate; cytotoxicity; drugs; inhibitory concentration 50; neoplasm cells; particle size; yeasts
Abstract:
... Several microorganisms were exploited as cell-factories for biogenic synthesis of different nanoparticles. Nanoparticles are recently showed effectiveness as drug-delivery systems for cancer treatment. Specially, copper nanoparticles were shown a high potency as drug delivery systems and cancer cell growth controllers. Herein, twenty marine yeast isolates were investigated for their capability to ...
DOI:
10.1016/j.bcab.2021.102261

19. Antioxidant and antimicrobial characteristics of chitosan and galbanum gum composite coating incorporated with cumin essential oil on the shelf life of chicken fillets

Author:
Leila Aghababaei; Maryam Hasani; Peyman Mahasti Shotorbani; Afshin Akhondzadeh Basti; Hassan Hamedi
Source:
Journal of food measurement & characterization 2022 v.16 no.3 pp. 1820-1833
ISSN:
2193-4126
Subject:
Enterobacteriaceae; Pseudomonas; Staphylococcus aureus; chickens; chitosan; cumin; essential oils; fillets; free radicals; inhibitory concentration 50; lactic acid; measurement; microbial load; peroxide value; refrigeration; shelf life; storage time; thiobarbituric acid; total volatile basic nitrogen; yeasts
Abstract:
... In this study, an edible composite coating of chitosan and galbanum gum containing cumin essential oil (CEO) was used to increase the shelf life of chicken fillets during a 12-day refrigeration period (4 ± 1 °C). In order to achieve the optimal concentration of essential oil, antioxidant (free radical scavenging DPPH) and antimicrobial properties (MIC and MBC values) were determined. Then, chicken ...
DOI:
10.1007/s11694-022-01295-4

20. Antioxidant and bioaccessibility characteristics of functional fruit and vegetable honeys produced by innovative method

Author:
M. Guldas; H. Demircan; I. Cakmak; R.A. Oral; E. Yildiz; O. Gurbuz; H. Tosunoglu; F. Cavus; H. Sen
Source:
Food bioscience 2022 v.48 pp. 101732
ISSN:
2212-4292
Subject:
acidity; antioxidant activity; antioxidants; bees; bioavailability; carrots; chlorogenic acid; fruits; gallic acid; honey; inhibitory concentration 50; pH; pomegranates
Abstract:
... The functional fruit and vegetable honeys were produced by the natural bee feeding method with pomegranate, orange and black carrot concentrates. The natural enrichment method did not cause any negative effects on the quality criteria questioned in the standards such as moisture, pH, free acidity and HMF (Hydroxymethylfurfuraldehyde) content and the quality of the functional honeys obtained was hi ...
DOI:
10.1016/j.fbio.2022.101732

21. Antiviral activity of chitosan nanoparticles encapsulating silymarin (Sil–CNPs) against SARS-CoV-2 (in silico and in vitro study)

Author:
Samah A. Loutfy; Ahmed I. Abdel-Salam; Yassmin Moatasim; Mokhtar R. Gomaa; Nasra F. Abdel Fattah; Merna H. Emam; Fedaa Ali; Hasnaa A. ElShehaby; Eman A. Ragab; Hanaa M. Alam El-Din; Ahmed Mostafa; Mohamed A. Ali; Amal Kasry
Source:
RSC advances 2022 v.12 no.25 pp. 15775-15786
ISSN:
2046-2069
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antiviral agents; antiviral properties; chitosan; computer simulation; cytotoxicity; gelation; gentian violet; inhibitory concentration 50; silymarin
Abstract:
... To develop a specific treatment against COVID-19, we investigated silymarin–chitosan nanoparticles (Sil–CNPs) as an antiviral agent against SARS-CoV-2 using in silico and in vitro approaches. Docking of Sil and CNPs was carried out against SARS-CoV-2 spike protein using AutoDock Vina. CNPs and Sil–CNPs were prepared by the ionic gelation method and characterized by TEM, FT-IR, zeta analysis, and t ...
DOI:
10.1039/d2ra00905f

22. Apoptotic, antioxidant and cytotoxic properties of synthesized AgNPs using green tea against human testicular embryonic cancer stem cells

Author:
Fahimeh Mobaraki; Mohsen Momeni; Maliheh Jahromi; Farshad Moharrami Kasmaie; Maryam Barghbani; Mohammad Ehsan Taghavizadeh Yazdi; Zahra Meshkat; Fatemeh Homaee Shandiz; Seyed Mousalreza Hosseini
Source:
Process biochemistry 2022 v.119 pp. 106-118
ISSN:
1359-5113
Subject:
Camellia sinensis; acridine orange; antioxidants; apoptosis; biosynthesis; caspase-3; cell lines; cost effectiveness; cytotoxicity; dose response; green tea; humans; inhibitory concentration 50; nanosilver; propidium; testes; ultraviolet-visible spectroscopy
Abstract:
... Silver nanoparticles (AgNPs) are known as carriers of anticancer activities for effectual target treatment of cancer cells. Plant-mediated synthesis for AgNPs synthesis is valuable for biomedical applications due to their more safety and cost-effectiveness. In this work, AgNPs were synthesized successfully using green tea (Camellia sinensis) extract (CSE-AgNPs). The physicochemical properties of C ...
DOI:
10.1016/j.procbio.2022.05.021

23. Arbuscular mycorrhiza and vermicompost alleviate drought stress and enhance yield, total flavonoid, rutin content, and antioxidant activity of buckwheat (Fagopyrum esculentum Moench)

Author:
Elnaz Mohammadi; Mohammad Fattahi; Mohsen Barin; Sanaz Ashrafi-Saeidlou
Source:
South African journal of botany 2022 v.148 pp. 588-600
ISSN:
0254-6299
Subject:
Fagopyrum esculentum; antioxidant activity; antioxidants; biomass; buckwheat; cluster analysis; field capacity; gallic acid; grain yield; greenhouse experimentation; inhibitory concentration 50; metabolites; nitrogen; phosphorus; potassium; principal component analysis; rutin; seed yield; symbionts; vermicomposts; vesicular arbuscular mycorrhizae; water stress
Abstract:
... The use of root symbionts and vermicompost as powerful natural tools is advised in stress conditions. To study the effect of vermicompost and mycorrhizal fungi on some phytochemicals and functional traits of buckwheat under drought stress, a greenhouse experiment was conducted. Three levels of drought stress: D0 (100% Field Capacity: FC), D1 (75% FC), and D2 (50% FC), two levels of mycorrhizal ino ...
DOI:
10.1016/j.sajb.2022.05.020

24. Association between TOP2A, RRM1, HER2, ERCC1 expression and response to chemotherapy in patients with non-muscle invasive bladder cancer

Author:
Zhifei Liu; Liyong Xing; Yanfeng Zhu; Peng Shi; Gang Deng
Source:
Heliyon 2022 v.8 no.6 pp. e09643
ISSN:
2405-8440
Subject:
DNA repair; Western blotting; drug therapy; drugs; flow cytometry; immunohistochemistry; inhibitory concentration 50; neoplasm cells; patients; protein subunits; protein synthesis; reverse transcriptase polymerase chain reaction; ribonucleotide reductase; urinary bladder neoplasms
Abstract:
... This study aimed to detect the expression levels of topoisomerase IIα (TOP2A), ribonucleotide reductase catalytic subunit M1 (RRM1),c-erbB-2 (HER2) and excision repair cross complementing group 1 (ERCC1) in non-muscular invasive bladder cancer (NMIBC) and explore the correlation between the expression of these genes and NMBIC sensitivity to pirarubicin or gemcitabine treatment. NMIBC patient tissu ...
DOI:
10.1016/j.heliyon.2022.e09643

25. Bioactives of Pomegranate By-Products and Barley Malt Grass Engage in Cereal Composite Bar to Achieve Antimycotic and Anti-Aflatoxigenic Attributes

Author:
Ebtihal Yaqoob Khojah; Ahmed Noah Badr; Dalia Amin Mohamed; Adel Gabr Abdel-Razek
Source:
Foods 2022 v.11 no.1 pp. -
ISSN:
2304-8158
Subject:
aflatoxins; antifungal properties; antioxidants; ascorbic acid; bioactive compounds; biosafety; cell death; cell lines; dough; fast foods; ferulic acid; grasses; inhibitory concentration 50; malting barley; people; pomegranates; sensory evaluation; shelf life
Abstract:
... Food is the source from where a person obtains the body’s daily requirements. People’s current daily habits force them to consume fast food, which is known for its poor nutritional and safety features. So, it is urgent to provide a suitable substitution product to solve this issue. The present investigation aimed to produce a bar with a dual function: nutritional and long shelf life. Two materials ...
DOI:
10.3390/foods11010119

26. Bioactivities of Some Wild Fruits Grown in Turkey

Author:
Osman Sagdic; Busra Polat; Hasan Yetim
Source:
Erwerbsobstbau 2022 v.64 no.2 pp. 299-305
ISSN:
0014-0309
Subject:
Aeromonas hydrophila; Celtis; Crataegus; Elaeagnus angustifolia; Malus floribunda; Pyracantha coccinea; Pyrus; Quercus robur; Rosa canina; Saccharomyces cerevisiae; Sorbus domestica; antimicrobial properties; antioxidants; edible fruits; food industry; fruit extracts; human nutrition; inhibitory concentration 50; pears; rose hips
Abstract:
... In this study some bioactive properties of extracts of wild pear (Pyrus elaegnifolia), hawthorn (Crataegus spp.), oriental hackberry (Celtis tournefortii), oleaster (Elaeagnus angustifolia), Japanese crabapple (Malus floribunda), rosehip (Rosa canina), pedunculate oak (Quercus robur), service tree (Sorbus domestica) and firethorn (Pyracantha coccinea) wildly growing in Turkey were investigated. Th ...
DOI:
10.1007/s10341-021-00631-0

27. Bioactivity of prenylated hydroxybenzoic acids from Piper garagaranum C. DC

Author:
Antonio Sáenz-Castillo; Jean Sanabria-Chinchilla; Alfonso J. García-Piñeres; Giselle Tamayo-Castillo
Source:
Phytochemistry letters 2022 v.47 pp. 28-33
ISSN:
1874-3900
Subject:
Piper; anti-inflammatory activity; antioxidants; cytotoxicity; electrochemistry; fractionation; inhibitory concentration 50; macrophages; mice; phytochemicals; voltammetry
Abstract:
... A bio-assay guided fractionation of Piper garagaranum C. DC. led to the isolation of two prenylated hydroxybenzoic acids (1-2) with anti-inflammatory and cytotoxic activities. The anti-inflammatory action was determined in an LPS stimulated RAW 264.7 murine macrophage assay with IC50 values for inhibition of NO production of (18 ± 3) and (26 ± 5) μM, for 1 and 2, respectively. These compounds do n ...
DOI:
10.1016/j.phytol.2021.10.018

28. Bioassay-guided isolation of antimycobacterial substances from the traditionally used lichen Cladonia pyxidata (L.) Hoffm.

Author:
Nguyen Huy Thuan; Haritha Polimati; Ramesh Alluri; Vinay Bharadwaj Tatipamula
Source:
3 Biotech 2022 v.12 no.4 pp. 95
ISSN:
2190-572X
Subject:
Cladonia; acetone; cytotoxicity; inhibitory concentration 50; lichens; macrophages; metabolites; rifampicin; tuberculosis; usnic acid
Abstract:
... The aim of the present study is to provide a scientific rationale for the folklore usage of Cladonia pyxidata (L.) Hoffm. in treating tuberculosis (Tb). Through bioassay-guided isolation, antimycobacterial metabolites were isolated from under-investigated lichen C. pyxidata and examined against M.t H37Ra and six MDR strains. Further, the cytotoxicity of all isolated metabolites was evaluated on TH ...
DOI:
10.1007/s13205-022-03159-6

29. Bound Polyphenols from Red Quinoa Prevailed over Free Polyphenols in Reducing Postprandial Blood Glucose Rises by Inhibiting α-Glucosidase Activity and Starch Digestion

Author:
Yu Zhang; Bing Bai; Yu Yan; Juan Liang; Xiao Guan
Source:
Nutrients 2022 v.14 no.4 pp. -
ISSN:
2072-6643
Subject:
acarbose; antioxidants; blood glucose; digestion; ferulic acid; functional foods; glucose; hydroxybenzoic acids; hyperglycemia; inhibitory concentration 50; noninsulin-dependent diabetes mellitus; polyphenols; starch
Abstract:
... Inhibiting α-glucosidase activity is important in controlling postprandial hyperglycemia and, thus, helping to manage type-2 diabetes mellitus (T2DM). In the present study, free polyphenols (FPE) and bound polyphenols (BPE) were extracted from red quinoa and their inhibitory effects on α-glucosidase and postprandial glucose, as well as related mechanisms, were investigated. HPLC-MS analysis showed ...
DOI:
10.3390/nu14040728

30. Britannin a Sesquiterpene Lactone from Inula aucheriana Exerted an Anti-leukemic Effect in Acute Lymphoblastic Leukemia (ALL) Cells and Enhanced the Sensitivity of the Cells to Vincristine

Author:
Hassan Mohammadlou; Maryam Hamzeloo-Moghadam; Amir Yami; Fatemeh Feizi; Marzieh Moeinifard; Ahmad Gharehbaghian
Source:
Nutrition and cancer 2022 v.74 no.3 pp. 965-977
ISSN:
1532-7914
Subject:
Inula; apoptosis; cytotoxicity; drug therapy; inhibitory concentration 50; interphase; lymphocytic leukemia; nutrition; sesquiterpenoids; synergism; viability; vincristine
Abstract:
... Since chemotherapy drugs have dose-related side effects, there is still a need for finding new agents with suitable cytotoxic effects without any harmful effects. For this purpose, we evaluated the cytotoxic effects of Britannin that is a Sesquiterpene Lactone compound Inula aucheriana, alone or in combination with Vincristine (VCR), on Acute Lymphoblastic Leukemia (ALL)-derived MOLT-4 cells. In t ...
DOI:
10.1080/01635581.2021.1931700

31. Caryocar brasiliense Camb. fruit peel butanolic fraction induces antiproliferative effects against murine melanoma cell line

Author:
Jéssica Nayara Basílio Silva; Victor Hugo Dantas Guimarães; Barbhara Mota Marinho; Amanda Souto Machado; Amanda Rodrigues Santos; Ludmilla Regina de Souza David; Geraldo Aclécio Melo; Alfredo Maurício Batista de Paula; Sérgio Henrique Sousa Santos
Source:
Phytomedicine plus 2022 v.2 no.2 pp. 100273
ISSN:
2667-0313
Subject:
Caryocar brasiliense; acridine orange; cancer therapy; cell death; cell lines; fruit peels; gallic acid; gas chromatography; inhibitory concentration 50; melanoma; mice; migratory behavior; skin neoplasms; traditional medicine
Abstract:
... Cutaneous malignant melanoma is a skin cancer type highly resistant to standard cancer therapies. Natural compounds have been reported as important sources for the creation of new drugs for cancer treatment. Caryocar brasiliense Camb., popularly known as Pequi, is often used in Brazilian folk medicine, with anticancer effects reported. Objectives: The present study evaluated the antiproliferative ...
DOI:
10.1016/j.phyplu.2022.100273

32. Cellular Cytotoxicity and Oxidative Potential of Recurrent Molds of the Genus Aspergillus Series Versicolores

Author:
Antoine Géry; Charlie Lepetit; Natacha Heutte; Virginie Séguin; Julie Bonhomme; David Garon
Source:
Microorganisms 2022 v.10 no.2 pp. -
ISSN:
2076-2607
Subject:
Aspergillus; air; bioaerosols; cell viability; cytotoxicity; dithiothreitol; ethyl acetate; fungi; inhibitory concentration 50; spores
Abstract:
... Molds are ubiquitous biological pollutants in bioaerosols. Among these molds, the genus Aspergillus is found in the majority of indoor air samples, and includes several species with pathogenic and toxigenic properties. Aspergillus species in the series Versicolores remain little known despite recurrence in bioaerosols. In order to investigate their toxicity, we studied 22 isolates of clinical and ...
DOI:
10.3390/microorganisms10020228

33. Chemical Characterization, Antioxidant, and Antihyperglycemic Capacity of Ferulated Arabinoxylan Extracted from “Chicha de Jora” Bagasse: An Ancestral Fermented Beverage from Zea mays L.

Author:
Juan Jharol Segovia-Huarcaya; Lilian Silvana Valentin-Soto; Oscar Herrera-Calderon; César Máximo Fuertes-Ruitón; Josefa Bertha Pari-Olarte; Eddie Loyola-Gonzales; José Santiago Almeida-Galindo; José Francisco Kong-Chirinos; Elizabeth Julia Melgar-Merino; Mohammed Merae Alshahrani; Shafi Mahmud
Source:
Journal of food quality 2022 v.2022 pp. -
ISSN:
1745-4557
Subject:
Zea mays; adsorption; alpha-amylase; antioxidant activity; antioxidants; arabinose; arabinoxylan; bagasse; fermented beverages; food quality; glucose; glycemic effect; inhibitory concentration 50; molecular weight; pH; thin layer chromatography; water content; xylose; Andes region; Peru
Abstract:
... Bagasse is a byproduct generated during the process of making the traditional Andean drink named “chicha de jora” in Peru, which is a potential source for the extraction of ferulated arabinoxylan (FAX). The aim of this study was to extract and characterize the FAX from bagasse and determine its antioxidant and antihyperglycemic capacity in vitro. As a result, FAX of molecular weight ≥3.5 kDa prese ...
DOI:
10.1155/2022/4015886

34. Chemical constituents from Diospyros fragrans Gürke (Ebenaceae)

Author:
Nathalie S. Jouwa Tameye; Carine Mvot Akak; Georges Bellier Tabekoueng; Pierre Mkounga; Gabin Thierry M. Bitchagno; Bruno N Lenta; Norbert Sewald; Augustin E. Nkengfack
Source:
Biochemical systematics and ecology 2022 v.100 pp. 104373
ISSN:
0305-1978
Subject:
Bacillus subtilis; Diospyros; acetates; acetylation; adenocarcinoma; allylation; antibacterial properties; betulinic acid; carotenoids; cervix; chemotaxonomy; cytotoxicity; ecology; humans; inhibitory concentration 50; polyols; spectral analysis; ursolic acid
Abstract:
... A new naphtalenone derivative named fragranone, alongside seventeen known compounds: ten triterpenoids, one monoglycerol, one polyterpenoid, one carotenoid, two steroids and two polyols were isolated from the leaves and roots of Diospyros fragrans. Four semi-synthetic derivatives obtained from the acetylation and allylation of betulinic acid, allylation of ursolic acid and acetylation of vismiaefo ...
DOI:
10.1016/j.bse.2021.104373

35. Chitosan Schiff bases-based polyelectrolyte complexes with graphene quantum dots and their prospective biomedical applications

Author:
Amira A. Hamed; Gamal R. Saad; Ismail A. Abdelhamid; Ahmed H.M. Elwahy; Marwa M. Abdel-Aziz; Maher Z. Elsabee
Source:
International journal of biological macromolecules 2022 v.208 pp. 1029-1045
ISSN:
0141-8130
Subject:
Helicobacter pylori; antibacterial properties; chemical structure; chitosan; electrolytes; graphene; inhibitory concentration 50; inosine; minimum inhibitory concentration; oxidoreductases; schiff bases
Abstract:
... Chitosan (Cs) bis-aldehyde Schiff base derivatives were synthesized by condensation of Cs with three bis-aldehydes namely; butane-1,4-diyl bis(4-formylbenzoate), N,N′-(butane-1,4-diyl)bis(2-(4-formylphenoxy)acetamide) and 4,4′-(butane-1,4-diylbis(oxy))dibenzaldehyde. The prepared Cs derivatives were blended with carboxymethyl chitosan(CMC) and graphene quantum dots (GQDs) to produce semi-IPNs poly ...
DOI:
10.1016/j.ijbiomac.2022.03.199

36. Chloride Toxicity to Native Freshwater Species in Natural and Reconstituted Prairie Pothole Waters

Author:
David D. Harper; Holly J. Puglis; Bethany K. Kunz; Aїda M. Farag
Source:
Archives of environmental contamination and toxicology 2022 v.82 no.3 pp. 416-428
ISSN:
0090-4341
Subject:
Daphnia magna; Lemna gibba; Pseudacris; chlorides; freshwater; frogs; hardness; indigenous species; inhibitory concentration 50; mortality; oils; pollution; surface water; toxicity; Prairie Pothole region
Abstract:
... Oil and gas extraction in the Prairie Pothole Region (PPR) of the northern USA has resulted in elevated chloride concentrations in ground and surface water due to widespread contamination with highly saline produced water, or brine. The toxicity of chloride is poorly understood in the high hardness waters characteristic of the region. We evaluated the toxicity of chloride to two endemic species, D ...
DOI:
10.1007/s00244-022-00927-6

37. Circ‐SNAP47 (hsa_circ_0016760) and miR‐625‐5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP‐tolerant NSCLC cells via ceRNA pathway

Author:
Can Zou; Feng Rong; Yan Zeng; Jing Zeng; Rong Wei; Dong Wei
Source:
Environmental toxicology 2022 v.37 no.2 pp. 224-236
ISSN:
1520-4081
Subject:
apoptosis; cell proliferation; cisplatin; ecotoxicology; humans; inhibitory concentration 50; lung neoplasms; microRNA; multiple drug resistance; xenotransplantation
Abstract:
... Circular RNA‐synaptosome associated protein 47 (circ‐SNAP47; Hsa_circ_0016760) is oncogenic in non‐small‐cell lung cancer (NSCLC); however, its role is undescribed in cis‐diamminedichloroplatinum II (DDP) resistance. We attempted to investigate its expression, role and mechanism in DDP‐tolerant NSCLC. As a result, circ‐SNAP47 expression was upregulated in human DDP‐tolerant NSCLC tissues and cells ...
DOI:
10.1002/tox.23391

38. Comprehensive analysis of the prognostic value and immune implications of the TTK gene in lung adenocarcinoma: a meta-analysis and bioinformatics analysis

Author:
Bo Li; Xiaojuan Gu; Hanbing Zhang; Hao Xiong
Source:
Animal cells and systems 2022 v.26 no.3 pp. 108-118
ISSN:
2151-2485
Subject:
DNA replication; adenocarcinoma; animals; bioinformatics; biomarkers; cell cycle; data collection; drug therapy; genes; homologous recombination; inhibitory concentration 50; lungs; meta-analysis; mutation; prognosis
Abstract:
... High expression levels of the TTK gene are closely related to tumor occurrence and poor prognosis, as confirmed by some studies. Our study explored the prognosis of lung adenocarcinoma (LUAD) patients with different TTK levels and the possible pathological mechanism of TTK in LUAD. We extensively searched literature databases and high-throughput sequencing databases and included relevant literatur ...
DOI:
10.1080/19768354.2022.2079718

39. Could Cisplatin Loading on Biosynthesized Silver Nanoparticles Improve Its Therapeutic Efficacy on Human Prostate Cancer Cell Line and Reduce Its In Vivo Nephrotoxic Effects?

Author:
Sawsan M. A. El-Sheikh; Nagah Edrees; Hend EL-Sayed; Tarek Khamis; Ahmed Hamed Arisha; Mohamed M. M. Metwally; Naglaa Z. Eleiwa; Azza A. A. Galal
Source:
Biological trace element research 2022 v.200 no.2 pp. 582-590
ISSN:
0163-4984
Subject:
B-cell lymphoma; adults; antioxidants; biosynthesis; body weight; cancer therapy; caspase-3; cisplatin; creatinine; cytotoxicity; drug therapy; erythrocytes; hemoglobin; humans; inhibitory concentration 50; leukocytes; males; nanosilver; neoplasm cells; nephrotoxicity; oxidants; prostatic neoplasms; research; trace elements; urea; viability
Abstract:
... Nanotechnology is a possible solution to the drawbacks of cancer therapy because it decreases the clinical side effects of chemotherapeutic drugs and increases their clinical activity. Thus, this work compared the in vitro cytotoxic activity and in vivo side effects of cisplatin (CP) with those of CP-loaded green silver nanoparticles (CP-AgNPs). The cytotoxic activity of CP, green AgNPs, and CP-Ag ...
DOI:
10.1007/s12011-021-02677-3

40. Cross-Species Comparison of Chemical Inhibition of Human and Xenopus Iodotyrosine Deiodinase

Author:
Jennifer H. Olker; Joseph J. Korte; Jonathan T. Haselman; Michael W. Hornung; Sigmund J. Degitz
Source:
Aquatic toxicology 2022 pp. 106227
ISSN:
0166-445X
Subject:
Xenopus laevis; amphibians; chemical hazards; enzyme activity; enzymes; hazard characterization; humans; inhibitory concentration 50; iodides; larvae
Abstract:
... The transition to include in vitro-based data in chemical hazard assessment has resulted in the development and implementation of screening assays to cover a diversity of biological pathways, including recently added assays to interrogate chemical disruption of proteins relevant to thyroid signaling pathways. Iodotyrosine deiodinase (IYD), the iodide recycling enzyme, is one such thyroid-relevant ...
DOI:
10.1016/j.aquatox.2022.106227

41. Cyperus iria aqueous-ethanol extract ameliorated hyperglycemia, oxidative stress, and regulated inflammatory cytokines in streptozotocin-induced diabetic rats

Author:
Myeda Saeed; Ali Sharif; Saeed Ul Hassan; Bushra Akhtar; Faqir Muhammad; Maryam Malik
Source:
Environmental science and pollution research 2022 v.29 no.3 pp. 4769-4784
ISSN:
0944-1344
Subject:
Cyperus iria; alpha-amylase; antioxidants; blood; carbohydrate metabolism; cytokines; dose response; ferulic acid; glucose; glycemic effect; high performance liquid chromatography; hyperglycemia; inhibitory concentration 50; kaempferol; metformin; noninsulin-dependent diabetes mellitus; oxidative stress; pollution; quercetin; research; streptozotocin; traditional medicine
Abstract:
... Type 2 diabetes mellitus is a complicated metabolic disorder with no definite treatment. Cyperus iria (Cyperaceae) possess several traditional therapeutic uses. According to the folklore tales, the whole plant of Cyperus iria possesses antihyperglycemic activity. The present study was undertaken to investigate whether aqueous-ethanol extract of Cyperus iria can ameliorate the altered activities of ...
DOI:
10.1007/s11356-021-15917-9

42. Cytochrome P450 Inhibition by Antimicrobials and Their Mixtures in Rainbow Trout Liver Microsomes In Vitro

Author:
Tea L.M. Pihlaja; Sanna M. Niemissalo; Tiina M. Sikanen
Source:
Environmental toxicology and chemistry 2022 v.41 no.3 pp. 663-676
ISSN:
0730-7268
Subject:
Oncorhynchus mykiss; bioaccumulation; chemistry; ciprofloxacin; clarithromycin; clotrimazole; cytochrome P-450; ecotoxicology; fish; inhibitory concentration 50; ketoconazole; liver microsomes; miconazole; risk; sulfamethoxazole; xenobiotics
Abstract:
... Antimicrobials are ubiquitous in the environment and can bioaccumulate in fish. In the present study, we determined the half‐maximal inhibitory concentrations (IC50) of 7 environmentally abundant antimicrobials (ciprofloxacin, clarithromycin, clotrimazole, erythromycin, ketoconazole, miconazole, and sulfamethoxazole) on the cytochrome P450 (CYP) system in rainbow trout (Oncorhynchus mykiss) liver ...
DOI:
10.1002/etc.5160

43. Cytotoxic and antimicrobial activities of new phytosteroids from the leaves of Anonidium mannii (Oliv.) Engl. & Diels (Annonaceae)

Author:
Michael H.K. Kamdem; Gervase P. Makoni; Kevine K. Silihe; Pangaman Jiyane; Jordan L. Tonga; Edwin M. Mmutlane; Charlotte M. Tata; Rui W.M. Krause; Derek T. Ndinteh
Source:
South African journal of botany 2022 v.147 pp. 628-635
ISSN:
0254-6299
Subject:
Annonaceae; Candida albicans; Enterococcus faecalis; Escherichia coli; HIV integrase; Mycobacterium tuberculosis; Plasmodium falciparum; Salmonella Typhi; Staphylococcus aureus; adenocarcinoma; antimalarials; cervix; ciprofloxacin; cytotoxicity; inhibitory concentration 50; lactate dehydrogenase; mass spectrometry; metabolites; minimum inhibitory concentration; parasites; proteinases; stigmasterol; uterine cervical neoplasms; viability
Abstract:
... Phytochemical studies of the dichloromethane-methanol (1:1) extract of the leaves of Anonidium mannii (Oliv.) Engl. & Diels led to the isolation of two new phytosteroids named anonimadiol A (AM1C) and B (AM2C) together with the known stigmasterol (AM3C). The structures of compounds were established by means of spectroscopic methods covering NMR analysis (¹H and ¹³C NMR, DEPT135, ¹H–¹H–COSY, HSQC a ...
DOI:
10.1016/j.sajb.2022.02.027

44. Cytotoxic effects of bioactive extracts from Andrographis echioides (L.) Nees: An In vitro approach

Author:
Sandhanasamy Devanesan; Amirtham J. Ranjitsingh; Mohamad S. AlSalhi; A. Murugan; Omar H. Abd Elkader; Marcello Nicoletti; Kathirvel Brindhadevi
Source:
Process biochemistry 2022 v.120 pp. 169-177
ISSN:
1359-5113
Subject:
Andrographis; DNA; apoptosis; cancer therapy; cell lines; cell proliferation; chromatography; cytotoxicity; drug therapy; flow cytometry; inhibitory concentration 50; leaf extracts; methanol; neoplasm cells
Abstract:
... In the global search for alternative drugs for various ailments, products from medicinal plants are given much attention. Attempts are being made to identify bioactive compounds from natural products to develop anticancer agents. In the present study exposes the cytotoxic activity of the extracts of the leaves of the plant Andrographis echioides on cancer cell lines. A. echioides leaf extract was ...
DOI:
10.1016/j.procbio.2022.06.008

45. Dataset of endo- and xenobiotic inhibition of CYP2B6: Comparison to CYP3A4

Author:
Emily M. Olack; Melissa M. Heintz; William S. Baldwin
Source:
Data in Brief 2022 v.41 pp. 108013
ISSN:
2352-3409
Subject:
HCH (pesticide); arachidonic acid; atrazine; avermectins; bile; bisphenol A; butylate; chlorpyrifos; cytochrome P-450; data collection; diazinon; diet; docosahexaenoic acid; endosulfan; enzymes; estradiol; fatty acid metabolism; fatty liver; fluorescence; humans; inhibitory concentration 50; linoleic acid; linolenic acid; lithocholic acid; nonylphenols; obesity; oleic acid; parathion; pentachlorophenol; pharmacokinetics; s,s,s-tributyl phosphorotrithioate; triclosan; vinclozolin; xenobiotics
Abstract:
... Cytochrome P450 2B6 (CYP2B6) is a human enzyme important in chemical detoxification, steroid and fatty acid metabolism that is primarily hepatic. Therefore, induction or inhibition of CYP2B6 may perturb endo- and xenobiotic metabolism and cause adverse reactions. Recent research indicates that mice lacking Cyp2b enzymes are obese with liver steatosis [1] (Heintz et al., J Nutr Biochem, 70:125–137, ...
DOI:
10.1016/j.dib.2022.108013

46. Designing of pretreatment filter technique for reduction of phenolic constituents from olive-mill wastewater and testing its impact on wheat germination

Author:
Sumera Shabir; Noshin Ilyas; Zia-ur-Rehman Mashwani; Muhammad Sheeraz Ahmad; Mysoon M. Al-Ansari; Latifah Al-Humaid; M.S. Reddy
Source:
Chemosphere 2022 v.299 pp. 134438
ISSN:
0045-6535
Subject:
adsorption; caffeic acid; carbon; catechol; coagulation; filtration; gallic acid; germination; gravel; inhibitory concentration 50; olive mill wastewater; olive oil; oxidants; pH; quercetin; sand; seedlings; stress tolerance; vanillic acid; vanillin; vigor; wheat
Abstract:
... Olive oil extraction produces a great volume of olive mill wastewater (OMW), which is considered a serious ecological challenge. In this study, we have designed and tested a trickling filter consisting of seven different layers of natural material, including (coarse gravel, fine gravel, lime (Ca (OH)₂), sand (SiO₂), carbon char, sponge/mesh), to treat OMW. The filter process involved physical sepa ...
DOI:
10.1016/j.chemosphere.2022.134438

47. Development and Characterization of Powdered Antioxidant Compounds Made from Shiraz (Vitis vinifera L.) Grape Peels and Arrowroot (Maranta arundinacea L.)

Author:
Euzélia Lima Souza; Talita Sousa Nascimento; Camila Miranda Magalhães; Gabriele de Abreu Barreto; Ingrid Lessa Leal; Jeancarlo Pereira dos Anjos; Bruna Aparecida Souza Machado
Source:
The scientific world journal 2022 v.2022 pp. -
ISSN:
1537-744X
Subject:
Maranta arundinacea; Vitis vinifera; antioxidant activity; antioxidants; arrowroot; catechin; epicatechin; food industry; gallic acid; grapes; inhibitory concentration 50; insoluble fiber; pulp
Abstract:
... Grapevine (Vitis vinifera L.) is a plant containing many phenolic compounds, mostly distributed in the peel, pulp, and seeds. This study evaluates the centesimal composition and bioactive compounds in Shiraz grape (Vitis vinifera) peels using spectrophotometric and UHPLC techniques and develops different formulations of compound powders from the peels and arrowroot using conventional drying techno ...
DOI:
10.1155/2022/7664321

48. Development of an Immunochromatographic Strip for the Rapid and Ultrasensitive Detection of Gamithromycin

Author:
Qianqian Lu; Xinxin Xu; Shanshan Song; Aihong Wu; Liqiang Liu; Hua Kuang; Chuanlai Xu
Source:
Food analytical methods 2022 v.15 no.3 pp. 598-606
ISSN:
1936-9751
Subject:
beef; cross reaction; gamithromycin; immunoaffinity chromatography; inhibitory concentration 50; milk; monoclonal antibodies; rapid methods
Abstract:
... In this study, we developed a monoclonal antibody (mAb)–based immunochromatographic strip for the detection of gamithromycin (GAM) residues in beef and milk samples. The mAb had a high sensitivity with a 50% inhibitory concentration (IC₅₀) of 0.537 ng/mL, and the cross-reactivity results indicated that the anti-GAM mAb also displayed a high specificity. The immunochromatographic strip gave cutoff ...
DOI:
10.1007/s12161-021-02146-6

49. Development of optimized novel liposome loaded with 6-gingerol and assessment of its therapeutic activity against NSCLC In vitro and In vivo experimental models

Author:
Priyadharshini Thangavelu; Viswanathan Sundaram; Kaavya Gunasekaran; Bonaventure Mujyambere; Sowndarya Raju; Arya Kannan; Ashok Arasu; Kadirvelu Krishna; Jayaraj Ramamoorthi; Sivasamy Ramasamy; Thirunavukkarasu Velusamy; Suja Samiappan
Source:
Chemistry and physics of lipids 2022 v.245 pp. 105206
ISSN:
0009-3084
Subject:
4',6-diamidino-2-phenylindole; active ingredients; apoptosis; cell cycle checkpoints; cell movement; cholesterol; cytotoxicity; drugs; ginger; hydrophobicity; inhibitory concentration 50; lung neoplasms; nanoemulsions; physical properties; response surface methodology; therapeutics; zeta potential
Abstract:
... 6-Gingerol (Gn) is an active compound derived from ginger which possesses various biological activities. The therapeutic applications of Gn are limited due to its hydrophobic nature. To ease its administration, one of the nano-emulsion methods, liposome was selected to encapsulate Gn. Response Surface Methodology (RSM) was used to optimize liposome ratio. 97.2% entrapment efficiency was achieved a ...
DOI:
10.1016/j.chemphyslip.2022.105206

50. Development of single- and multiplex immunoassays for rapid detection and quantitation of amodiaquine in ACT drugs and rat serum

Author:
Jingqi Qian; Mian Wang; Zhaoxiang Wang; Rui Feng; Jiaqi Zhang; Chencheng Ye; Man Zhang; Baomin Wang; Liwang Cui
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.4 pp. 1631-1640
ISSN:
1618-2642
Subject:
analytical chemistry; antimalarials; blood serum; cross reaction; enzyme-linked immunosorbent assay; equipment; high performance liquid chromatography; inhibitory concentration 50; intragastric administration; malaria; metabolites; pharmacokinetics; qualitative analysis; quality control; rapid methods; rats
Abstract:
... Amodiaquine (AQ) is a commonly used antimalarial drug, and N-desethyl-AQ (N-DEAQ) is an active metabolite of AQ. Given the significance of drug quality in the management of malaria cases, this study aims to develop antibody-based assays for the detection and quantitation of AQ without the need for sophisticated equipment. Two monoclonal antibodies (mAbs) against AQ, designated as JUN7 and TE7, wer ...
DOI:
10.1007/s00216-021-03787-6