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- Wang, Qian-qian; Zhou, Biao; Ji, Yuan-yuan; Zhang, Hao-jian; Ma, Zhong-jun; Shen, Li; Ding, Wan-jing
- Phytochemistry letters 2019
- anthracyclines, etc ; Streptomyces; circular dichroism spectroscopy; cytotoxicity; density functional theory; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy; prostatic neoplasms; spectral analysis; Show all 10 Subjects
- ... Six new anthracyclines (1-6) were obtained by the investigation of the solid fermented extract of a marine-derived Streptomyces sp. NB-A13. The structures were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR, HRESIMS, UV and IR. The absolute configurations of compounds 1-5 were established by calculated electronic circular dichroism (ECD) using time dependent density fun ...
- Khalil, Zeinab
G.; Raju, Ritesh; Piggott, Andrew M.; Salim, Angela
A.; Blumenthal, Antje; Capon, Robert J.
- Journal of natural products 2015 v.78 no.4 pp. 949-952
- anthracyclines, etc ; Gram-negative bacteria; Gram-positive bacteria; Mycobacterium tuberculosis; Streptomyces; antibiotics; chemical analysis; cytotoxicity; fungi; humans; inhibitory concentration 50; neoplasms; spectral analysis; Show all 13 Subjects
- ... Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1–4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC₅₀ >30 μM) and exh ...
- Kennedy, Steven; DiCesare, John C.; Sheaff, Robert J.
- Biochemical and biophysical research communications 2011 v.408 no.1 pp. 94-98
- anthracyclines, etc ; DNA topoisomerase; cell death; cell viability; drug therapy; drugs; eukaryotic cells; inhibitory concentration 50; isoquinolines; mechanism of action; plasmids; topoisomerase inhibitors; Show all 12 Subjects
- ... In an attempt to create more effective chemotherapeutic compounds, the naphthoquinone adduct 12,13-dihydro-N-methyl-6,11,13-trioxo-5H-benzo[4,5]cyclohepta[1,2-b]naphthalen-5,12-imine (hereafter called TU100) was synthesized. Cell viability studies revealed TU100 is specific for eukaryotes and induces cell death. Based on its structural similarities to the anthracyclines and isoquinolines, the abil ...