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- Lepage, Patricia, et al. Show all 8 Authors
- Analytical and bioanalytical chemistry 2017 v.409 no.5 pp. 1231-1245
- Collinsella aerofaciens; Eggerthella lenta; bile acids; bioavailability; cell culture; cholesterol; choloylglycine hydrolase; culture media; energy; fermentation; glucose; intestinal microorganisms; liquid chromatography; liquid-liquid extraction; metabolic diseases; metabolites; mice; rapid methods; tandem mass spectrometry; taurine; tissues
- ... Bile acids are important signaling molecules that regulate cholesterol, glucose, and energy homoeostasis and have thus been implicated in the development of metabolic disorders. Their bioavailability is strongly modulated by the gut microbiota, which contributes to generation of complex individual-specific bile acid profiles. Hence, it is important to have accurate methods at hand for precise meas ...
- Lepage, Patricia, et al. Show all 33 Authors
- Science 2013 v.342 no.6161 pp. 971-976
- adaptive immunity; colorectal neoplasms; cyclophosphamide; cytosine; drug therapy; guanosine; immunotherapy; innate immunity; intestinal microorganisms; mice; oligonucleotides; platinum
- ... The Microbiota Makes for Good Therapy The gut microbiota has been implicated in the development of some cancers, such as colorectal cancer, but—given the important role our intestinal habitants play in metabolism—they may also modulate the efficacy of certain cancer therapeutics. Iida et al. (p. 967) evaluated the impact of the microbiota on the efficacy of an immunotherapy [CpG (the cytosine, gua ...
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