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1. Photoimmunotherapy with cetuximab-conjugated gold nanorods reduces drug resistance in triple negative breast cancer spheroids with enhanced infiltration of tumor-associated macrophages

Author:
Fakhrossadat Emami; Shiva Pathak; Tiep Tien Nguyen; Prakash Shrestha; Srijan Maharjan; Jong Oh Kim; Jee-Heon Jeong; Simmyung Yook
Source:
Journal of controlled release 2021 v.329 pp. 645-664
ISSN:
0168-3659
Subject:
breast neoplasms; cell culture; cytotoxicity; doxorubicin; drug resistance; epidermal growth factor receptors; gene expression regulation; gold; inhibitory concentration 50; interleukin-10; irradiation; macrophages; mannose; models; nanogold; nanorods; near infrared radiation; patients; phenotype; prognosis; protein synthesis; reactive oxygen species; stromal cells; therapeutics
Abstract:
... Tumor-associated macrophages (TAM) constitute up to 50–80% of stromal cells in breast cancer (BC), and are correlated with poor prognosis. As epidermal growth factor receptor (EGFR) is overexpressed in 60–80% of patients with triple negative breast cancer (TNBC), photoimmunotherapy (PIT) with cetuximab-targeted gold nanorods (CTX-AuNR) is an attractive therapeutic strategy for TNBC. The 3D cell cu ...
DOI:
10.1016/j.jconrel.2020.10.001

2. AIEgens Conjugation Improves the Photothermal Efficacy and Near-Infrared Imaging of Heptamethine Cyanine IR-780

Author:
Xiujie Zhao; Zhiwen Fan; Yanqi Qiao; Yun Chen; Shuo Wang; Xinmin Yue; Tangliang Shen; Wenting Liu; Jie Yang; Heqi Gao; Xuelin Zhan; Luqing Shang; Yongmei Yin; Wei Zhao; Dan Ding; Rimo Xi; Meng Meng
Source:
ACS applied materials & interfaces 2020 v.12 no.14 pp. 16114-16124
ISSN:
1944-8252
Subject:
cytotoxicity; fluorescent dyes; human cell lines; image analysis; inhibitory concentration 50; irradiation; mice; near-infrared spectroscopy; photosensitizing agents; photostability; precision medicine
Abstract:
... Near-infrared (NIR) fluorescent probes can deeply penetrate through tissues with little damage. To facilitate image-guided theranostics, researchers usually apply a desired amount of photosensitizers to achieve effective photothermal responses. However, these probes could easily suffer from low photostability and aggregated-caused quenching effect in high concentrations. In this paper, the rationa ...
DOI:
10.1021/acsami.0c01715

3. Crown- and phosphoryl-containing metal phthalocyanines in solutions of poly(N-vinylpyrrolidone): Supramolecular organization, accumulation in cells, photo-induced generation of reactive oxygen species, and cytotoxicity

Author:
Mariya Lapshina; Aleksey Ustyugov; Vladimir Baulin; Alexei Terentiev; Aslan Tsivadze; Nataliya Goldshleger
Source:
Journal of photochemistry and photobiology 2020 v.202 pp. 111722
ISSN:
1011-1344
Subject:
cytotoxicity; fluorescence; human cell lines; humans; inhibitory concentration 50; irradiation; neoplasm cells; photochemotherapy; photosensitizing agents; reactive oxygen species; water solubility; zinc
Abstract:
... Nowadays, the study of well-known sensitizers for photodynamic therapy and search for new ones are intensively conducted. In the present work supramolecular organization of crown-ether and phosphoryl-containing phthalocyanines ({Mgcr₈Pc, I, and М[R₄Pc] (M = Zn²⁺, R = -OPhP(O)(OH)(OC₅H₁₁), II; M = 2H⁺, R = -OPhP(O)(OH)(OC₅H₁₁), III; M = 2H⁺, -OPhP(O)(OH)₂), IIIa}, respectively) was studied in micro ...
DOI:
10.1016/j.jphotobiol.2019.111722

4. In vitro studies on antioxidant and cyto-protective activities of polyphenol-rich fraction isolated from Mangifera indica leaf

Author:
Kannan Nivedha; Sivaperumal Sivasakthi; Anand Prakash; Nagarajan Devipriya; Vellingiri Vadivel
Source:
South African journal of botany 2020 v.130 pp. 396-406
ISSN:
0254-6299
Subject:
2,2-diphenyl-1-picrylhydrazyl; Mangifera indica; antioxidant activity; chloroform; cytotoxicity; ethyl acetate; gallic acid; hexane; hydrogen peroxide; hydroxyl radicals; in vitro studies; inhibitory concentration 50; irradiation; leaf extracts; leaf mass; leaves; liquid chromatography; mangoes; methanol; models; mononuclear leukocytes; oxidative stress; radioprotective effect; salicylic acid; screening; solvents; superoxide anion; tandem mass spectrometry
Abstract:
... Present work was carried out with the objectives to isolate polyphenol-rich fraction from Mangifera indica leaves and its analysis in LC–MS/MS and also to investigate the antioxidant potential and cyto-protective activity of the active fraction against UV radiation-induced oxidative stress in PBMC model. M. indica leaf extracts were prepared using solvents of different polarity (hexane, chloroform ...
DOI:
10.1016/j.sajb.2020.01.019

5. Multimodal image-guided folic acid targeted Ag-based quantum dots for the combination of selective methotrexate delivery and photothermal therapy

Author:
Mahshid Hashemkhani; Abdullah Muti; Alphan Sennaroğlu; Havva Yagci Acar
Source:
Journal of photochemistry and photobiology 2020 v.213 pp. 112082
ISSN:
1011-1344
Subject:
biocompatibility; folate receptors; folic acid; glutathione; inhibitory concentration 50; irradiation; methotrexate; necrosis; neoplasms; pH; photobiology; photochemistry; photothermotherapy; temperature
Abstract:
... Multifunctional quantum dots (QDs) with photothermal therapy (PTT) potential loaded with an anticancer drug and labelled with a targeting agent can be highly effective nano-agents for tumour specific, image-guided PTT/chemo combination therapy of cancer. Ag-chalcogenides are promising QDs with good biocompatibility. Ag₂S QDs are popular theranostic agents for imaging in near-infrared with PTT pote ...
DOI:
10.1016/j.jphotobiol.2020.112082

6. Naturally available hypericin undergoes electron transfer for type I photodynamic and photothermal synergistic therapy

Author:
Zhen Ke; Aize Xie; Jianjiao Chen; Zhenyuan Zou; Lei Shen; Yansong Dai; Dengfeng Zou
Source:
Biomaterials science 2020 v.8 no.9 pp. 2481-2487
ISSN:
2047-4849
Subject:
Hypericum; antineoplastic activity; cancer therapy; electron transfer; energy transfer; heart; heat; human diseases; hydroxyl radicals; hypericin; in vivo studies; inhibitory concentration 50; irradiation; kidneys; liver; lungs; nanoparticles; neoplasm cells; photochemotherapy; photothermotherapy; polyethylene glycol; singlet oxygen; spleen; superoxide anion; uterine cervical neoplasms
Abstract:
... Naturally available compounds with bioactivity are potential candidates for cancer treatment. In this paper, we isolated hypericin (HC) from Hypericum sinense L. and investigated its antitumor activity both in vitro and in vivo. The nanoparticles (NPs) of HC were prepared by a nanoprecipitation process with 1,2-distearoyl-sn-glycero-3-phospho-ethanolamine-N-[methoxy(polyethylene glycol)₋₂₀₀₀] (DSP ...
DOI:
10.1039/d0bm00021c

7. Assessment of the bioactive components, antioxidant, antiglycation and anti-inflammatory properties of Aquilaria crassna Pierre ex Lecomte leaves

Author:
Eakkaluk Wongwad; Chitaporn Pingyod; Tongchai Saesong; Neti Waranuch; Wudtichai Wisuitiprot; Boonchoo Sritularak; Prapapan Temkitthawon; Kornkanok Ingkaninan
Source:
Industrial crops and products 2019 v.138 pp. 111448
ISSN:
0926-6690
Subject:
2,2-diphenyl-1-picrylhydrazyl; Aquilaria crassna; active ingredients; anti-inflammatory activity; antioxidant activity; bioactive compounds; blood serum; cattle; cosmetics; flowers; humans; industry; inhibitory concentration 50; interleukin-1alpha; interleukin-8; irradiation; keratinocytes; leaf extracts; leaves; lipoxygenases; macrophages; nitric oxide; prostaglandins; thiocyanates; ultraviolet radiation; Thailand
Abstract:
... Aquilaria crassna Pierre ex Lecomte leaf might be a potential source of natural ingredients for anti-ageing cosmetics. Our study objectives were to assess the variation of the bioactive components i.e. iriflophenone 3,5-C-β-d-diglucoside (1), iriflophenone 3-C-β-d-glucoside (2), mangiferin (3) and genkwanin 5-O-β-primevoside (4) in leaves and other parts of the plants collected from different plac ...
DOI:
10.1016/j.indcrop.2019.06.011

8. Biofabrication of iron oxide nanoparticles as a potential photocatalyst for dye degradation with antimicrobial activity

Author:
M. Kamaraj; T. Kidane; K. U. Muluken; J. Aravind
Source:
International journal of environmental science and technology 2019 v.16 no.12 pp. 8305-8314
ISSN:
1735-1472
Subject:
Bacillus (bacteria); Escherichia coli; Fourier transform infrared spectroscopy; Gram-positive bacteria; Proteus; Pseudomonas; Salmonella; Staphylococcus; Streptococcus; agar; antimicrobial properties; avocados; biodegradability; biofabrication; cervix; cytotoxicity; decolorization; epithelium; fruit peels; gentian violet; humans; inhibitory concentration 50; iron oxides; irradiation; malachite green; methyl orange; nanoparticles; neoplasm cells; photocatalysts; phytochemicals; reducing agents; remediation; solar radiation
Abstract:
... In the current investigation presented here, avocado fruit rind aqueous extract was exploited to make iron oxide nanoparticles, in a cost competent and eco-cordial method. The Fourier transform infrared analysis exhibited that the phytochemicals which were in the avocado fruit rind acted as biodegradable, stabilizing and reducing agents in the iron oxide nanoparticles biofabrication. The nanoparti ...
DOI:
10.1007/s13762-019-02402-7

9. Cationic octahedral molybdenum cluster complexes functionalized with mitochondria-targeting ligands: photodynamic anticancer and antibacterial activities

Author:
Kaplan Kirakci; Jaroslav Zelenka; Michaela Rumlová; Josef Cvačka; Tomáš Ruml; Kamil Lang
Source:
Biomaterials science 2019 v.7 no.4 pp. 1386-1392
ISSN:
2047-4849
Subject:
Enterococcus faecalis; Gram-positive bacteria; Staphylococcus aureus; antibacterial properties; blue light; human cell lines; hydrophilicity; inhibitory concentration 50; irradiation; ligands; luminescence; lysosomes; mitochondria; molybdenum; nanocarriers; neoplasms; photochemotherapy; photosensitizing agents; phototoxicity; singlet oxygen
Abstract:
... Octahedral molybdenum cluster complexes have recently come forth as pertinent singlet oxygen photosensitizers towards biological applications. Still, their phototoxic efficiency in the absence of nanocarriers remains limited due to their poor cellular uptake. Here, two cationic octahedral molybdenum cluster complexes, bearing carboxylate ligands with triphenylphosphonium (1) or N-methyl pyridinium ...
DOI:
10.1039/c8bm01564c

10. Effects of different UV radiation on photoprotective pigments and antioxidant activity of the hot‐spring cyanobacterium Leptolyngbya cf. fragilis

Author:
Maryam Kokabi; Morteza Yousefzadi; Maryam Soltani; Mitra Arman
Source:
Phycological research 2019 v.67 no.3 pp. 215-220
ISSN:
1322-0829
Subject:
Leptolyngbya; antioxidant activity; antioxidants; biosynthesis; carotenoids; ethyl acetate; hot springs; inhibitory concentration 50; irradiation; phycocyanin; phycoerythrin; pigments; radiation resistance; ultraviolet radiation
Abstract:
... UV‐induced synthesis/accumulation of photoprotective pigments and antioxidant activity were investigated in the hot‐spring cyanobacterium Leptolyngbya cf. fragilis. The results indicated that UV radiation may induce biosynthesis of carotenoids, allophycocyanin, phycoerythrin, and scytonemin while phycocyanin degrades in response to longtime UV radiation. Moreover, pigment composition of L. cf. fra ...
DOI:
10.1111/pre.12374

11. Enhanced cellular uptake and photochemotherapeutic potential of a lipophilic strained Ru(ii) polypyridyl complex

Author:
Stephanie Mehanna; Najwa Mansour; Hassib Audi; Kikki Bodman-Smith; Mohamad A. Mroueh; Robin I. Taleb; Costantine F. Daher; Rony S. Khnayzer
Source:
RSC advances 2019 v.9 no.30 pp. 17254-17265
ISSN:
2046-2069
Subject:
apoptosis; cell lines; cisplatin; culture media; flow cytometry; gel electrophoresis; inhibitory concentration 50; irradiation; ligands; lipophilicity; melanoma; necrosis; photochemistry; photochemotherapy; phototoxicity; plasmids; ruthenium
Abstract:
... The use of ruthenium complexes as chemotherapeutic agents has been recently explored as one of the alternatives to conventional treatments. In the present study, two Ru(ii) polypyridyl complexes were synthesized and characterized: a strained [Ru(bipy)₂(BC)]Cl₂ (complex 1) where [bipy = 2,2′-bipyridine and BC = bathocuproine] along with the unstrained control [Ru(bipy)₂(phen)]Cl₂ (complex 2) where ...
DOI:
10.1039/c9ra02615k

12. Extraction of essential oils of Ferulago angulata with microwave-assisted hydrodistillation

Author:
Saeed Mollaei; Farzaneh Sedighi; Biuck Habibi; Saeid Hazrati; Parina Asgharian
Source:
Industrial crops and products 2019 v.137 pp. 43-51
ISSN:
0926-6690
Subject:
Apiaceae; alpha-phellandrene; alpha-pinene; antioxidant activity; antioxidants; energy; essential oils; fruits; gas chromatography-mass spectrometry; hydrodistillation; inhibitory concentration 50; irradiation; limonene; medicinal plants; microwave treatment; perfumes; pharmaceutical industry; response surface methodology; terpinolene; Iran
Abstract:
... Ferulago angulata (Apiaceae), an important medicinal plant of Iran, has been considered to have different therapeutical effects and are widely used in the perfume and pharmacological industries. Considering capability of F. angulata essential oils, the present study was conducted to optimized microwave-assisted hydrodistillation (MAHD) method for F. angulata fruit in order to improve the yield and ...
DOI:
10.1016/j.indcrop.2019.05.015

13. Fabrication of MgO nanostructures and its efficient photocatalytic, antibacterial and anticancer performance

Author:
K. Karthik; S. Dhanuskodi; C. Gobinath; S. Prabukumar; S. Sivaramakrishnan
Source:
Journal of photochemistry and photobiology 2019 v.190 pp. 8-20
ISSN:
1011-1344
Subject:
Aeromonas hydrophila; Bacillus subtilis; Escherichia coli; Fourier transform infrared spectroscopy; Gram-negative bacteria; Proteus mirabilis; Rhodococcus rhodochrous; Salmonella Typhi; Shigella flexneri; Vibrio cholerae; X-ray diffraction; antibacterial properties; aqueous solutions; confocal laser scanning microscopy; crystallites; decolorization; erythrocytes; human cell lines; humans; inhibitory concentration 50; irradiation; lung neoplasms; magnesium oxide; methylene blue; microwave treatment; monitoring; nanomaterials; neoplasm cells; photocatalysis; photolysis; scanning electron microscopy; solar radiation; toxicity; transmission electron microscopy
Abstract:
... Magnesium oxide (MgO) nanostructures were prepared using microwave-assisted (M 1) and hydrothermal (M 2) methods and characterized by XRD, SEM and FT-IR. It exhibits cubic structure with an average crystallite size of 20 nm (M 1) and 14 nm (M 2) and the lattice strain (WH plot) is 0.0017 (M 1), 0.0037 (M 2). It's spherical and rods like structures are confirmed through SEM and TEM. The vibrational ...
DOI:
10.1016/j.jphotobiol.2018.11.001

14. Folate receptor-targeted liposomal nanocomplex for effective synergistic photothermal-chemotherapy of breast cancer in vivo

Author:
Van Du Nguyen; Hyun-Ki Min; Chang-Sei Kim; Jiwon Han; Jong-Oh Park; Eunpyo Choi
Source:
Colloids and surfaces 2019 v.173 pp. 539-548
ISSN:
0927-7765
Subject:
breast neoplasms; cell proliferation; colloids; doxorubicin; drug delivery systems; drug therapy; folic acid; gold; in vivo studies; inhibitory concentration 50; irradiation; mice; nanogold; nanorods; near-infrared spectroscopy; neoplasm cells; pH; photothermotherapy; remission; toxicity
Abstract:
... An effective nanoparticle-based drug delivery platform holds great promise for non-invasive cancer therapy. This study explores the breast tumor regression in vivo by synergistic photothermal-chemotherapy based on liposomal nanocomplex (folic acid-gold nanorods-anticancer drug-liposome). The proposed liposomal nanocomplex can enhance the tumor targeting by functionalizing folic acid (FA) molecules ...
DOI:
10.1016/j.colsurfb.2018.10.013

15. In vitro antioxidant and photoprotective activity of five native Brazilian bamboo species

Author:
Katarzyna Barbara Wróblewska; André Rolim Baby; Maria Tereza Grombone Guaratini; Paulo Roberto Hrihorowitsch Moreno
Source:
Industrial crops and products 2019 v.130 pp. 208-215
ISSN:
0926-6690
Subject:
2,2-diphenyl-1-picrylhydrazyl; Aulonemia; Chusquea; UV filters; absorption; active ingredients; antioxidant activity; antioxidants; bamboos; culms; filters; gallic acid; inhibitory concentration 50; irradiation; leaves; pharmaceutical industry; photostability; quercetin; radiation resistance; sunscreens; transmittance; wavelengths; Brazil
Abstract:
... Nature provides an abundant source of antioxidant substances as well as potential compounds for sunscreen products. Asian bamboos, well known and widely cultivated, are already used in cosmetic and pharmaceutical industries thanks to their rich phenolic contents which is related to their antioxidant activity. This study aimed to evaluate the photoprotective and antioxidant activities of five nativ ...
DOI:
10.1016/j.indcrop.2018.12.081

16. Incorporation of 7-dehydrocholesterol into liposomes as a simple, universal and efficient way to enhance anticancer activity by combining PDT and photoactivated chemotherapy

Author:
Youchao Wang; Nana Tian; Chao Li; Yuanjun Hou; Xuesong Wang; Qianxiong Zhou
Source:
Chemical communications 2019 v.55 no.93 pp. 14081-14084
ISSN:
1364-548X
Subject:
7-dehydrocholesterol; antineoplastic activity; cholesterol; inhibitory concentration 50; irradiation; photochemotherapy; photooxidation; singlet oxygen
Abstract:
... Cholesterol (CHOL) is an indispensable component of liposomes. Incorporation of 7-dehydrocholesterol (7-DHC) instead of CHOL can efficiently enhance the anticancer activity of photosensitizer-encapsulated liposomes upon irradiation, yielding an IC₅₀ value about half of that of CHOL-based controls. The photo-oxidation of 7-DHC into its endoperoxide form by singlet oxygen may account for the enhance ...
DOI:
10.1039/c9cc05691b

17. Intensification in biological properties of chitosan after γ-irradiation

Author:
Abhijeet B. Muley; Mayur R. Ladole; Penna Suprasanna; Sunil G. Dalvi
Source:
International journal of biological macromolecules 2019 v.131 pp. 435-444
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Alternaria; Fourier transform infrared spectroscopy; Fusarium; X-ray diffraction; acetylation; antimicrobial properties; antioxidant activity; antioxidants; biopolymers; chitosan; chlorophyll; crystal structure; differential scanning calorimetry; energy; enthalpy; gamma radiation; inhibitory concentration 50; irradiation; leaves; minimum inhibitory concentration; molecular weight; phase transition; plant growth; potatoes; sugars; temperature; thermogravimetry; ultraviolet-visible spectroscopy
Abstract:
... Chitosan, a functional biopolymer, was irradiated with 100 kGy gamma irradiation and used to access its physical, antioxidant, plant growth promoting and antimicrobial properties. The molecular weight of chitosan reduced to 82.2 kDa from 337.7 kDa after irradiation. UV–Vis spectroscopy and FTIR results revealed slight changes in chitosan skeleton after irradiation but the degree of acetylation of ...
DOI:
10.1016/j.ijbiomac.2019.03.072

18. NIR-excited superoxide radical procreators to eradicate tumors by targeting the lyso-membrane

Author:
Bhaskar Gurram; Miao Li; Mingle Li; Kalayou H. Gebremedhin; Wen Sun; Jiangli Fan; Jingyun Wang; Xiaojun Peng
Source:
Journal of materials chemistry B 2019 v.7 no.28 pp. 4440-4450
ISSN:
2050-7518
Subject:
antineoplastic activity; apoptosis; bacteria; chemistry; flow cytometry; fluorescence; free radicals; image analysis; inhibitory concentration 50; irradiation; lysosomes; neoplasm cells; neoplasms; photochemotherapy; photosensitizing agents; superoxide anion
Abstract:
... NIR photosensitizers have been used as potential photo-activators to inhibit cancer cells as well as the growth of various types of bacteria. Herein, we first designed NIR alkylated cationic photosensitizers (Et-NB-C12 > Et-NB-C18 and Mt-NB-C12 > Mt-NB-C18), which target the lyso-membrane for the eradication of tumor cells through prominent superoxide radical generation (type-I PDT) via the lysoso ...
DOI:
10.1039/c9tb00721k

19. One new sesquiterpene and one new iridoid derivative from Valeriana amurensis

Author:
Yang-Guo Xie; Xin-Cai Zhao; Syed Shams ul Hassan; Xiao-Yong Zhen; Ishaq Muhammad; Shi-kai Yan; Xing Yuan; Hui-liang Li; Hui-zi Jin
Source:
Phytochemistry letters 2019 v.32 pp. 6-9
ISSN:
1874-3900
Subject:
Valeriana; X-ray diffraction; anti-inflammatory activity; inhibitory concentration 50; irradiation; macrophages; nitric oxide; sesquiterpenoids; spectral analysis; stereochemistry
Abstract:
... One new sesquiterpene 1S, 3S, 4S, 7S 3,4-dihydroxy-bisabolol (1), one new iridoid amurensin A (2) and 10 known compounds were isolated from the whole plants of Valeriana amurensis. Their structures were established on the basis of extensive spectroscopic analysis and the absolute stereochemistry of compound 1 was assigned by X-ray diffraction analysis with Cu-Kα irradiation. All of compounds were ...
DOI:
10.1016/j.phytol.2019.04.020

20. Organic small molecular nanoparticles based on self-assembly of amphiphilic fluoroporphyrins for photodynamic and photothermal synergistic cancer therapy

Author:
Lixia Yang; Haolan Li; Dan Liu; Huifang Su; Kai Wang; Genyan Liu; Xiaogang Luo; Fengshou Wu
Source:
Colloids and surfaces 2019 v.182 pp. 110345
ISSN:
0927-7765
Subject:
absorption; biocompatibility; fluorescence; hydrophilicity; in vitro studies; inhibitory concentration 50; irradiation; moieties; nanoparticles; neoplasm cells; neoplasms; organic matter; permeability; photosensitizing agents; polyethylene glycol; porphyrins; spectral analysis; therapeutics
Abstract:
... Two new porphyrin-based organic compounds (Por and ZnPor) were synthesized by introducing hydrophilic polyethylene glycol chains and pentafluorobenzene moieties onto the parent porphyrin structure. After self-assembling into nanoparticles, the absorption spectrum of (Zn)Por NPs broadened and red-shifted to some extent, relative to that of organic molecules. Meanwhile, the fluorescence of organic m ...
DOI:
10.1016/j.colsurfb.2019.110345

21. All-active antitumor micelles via triggered lipid peroxidation

Author:
Min Gao; Xuan Meng; Xuliang Guo; Jundong Zhu; Aiping Fan; Zheng Wang; Yanjun Zhao
Source:
Journal of controlled release 2018 v.286 pp. 381-393
ISSN:
0168-3659
Subject:
active ingredients; aldehydes; antineoplastic agents; cell cycle checkpoints; cytotoxicity; engineering; free radicals; inhibitory concentration 50; interphase; irradiation; lipid peroxidation; mice; micelles; nanocarriers; nanomedicine; neoplasm cells; permeability; photosensitizing agents; singlet oxygen; unsaturated fatty acids
Abstract:
... Traditional antitumor nanomedicines have been suffering from the poor tumor targeting (ca. 1%) by the enhanced permeability and retention (EPR) effect, and the low drug loading (<5%). It was postulated that engineering all-active nanoplatform could increase the therapeutic efficacy to enable the nanocarrier function as both vehicle and active ingredient. To achieve this, a photosensitizer, Ce6 was ...
DOI:
10.1016/j.jconrel.2018.08.003

22. Functional aza-boron dipyrromethenes for subcellular imaging and organelle-specific photodynamic therapy

Author:
Qiong Wang; Dennis K. P. Ng; Pui-Chi Lo
Source:
Journal of materials chemistry 2018 v.6 no.20 pp. 3285-3296
ISSN:
2050-7518
Subject:
adenocarcinoma; apoptosis; breast neoplasms; colon; confocal microscopy; hepatoma; human cell lines; humans; hydrophilicity; image analysis; inhibitory concentration 50; irradiation; lysosomes; mitochondria; morpholine; neoplasm cells; photochemotherapy; photosensitizing agents; singlet oxygen; uterine cervical neoplasms
Abstract:
... Two hydrophilic aza-boron dipyrromethene (aza-BODIPY) derivatives have first been designed and synthesised for subcellular imaging. With a triphenylphosphonium or morpholine substituent, these probes show high affinity towards the mitochondria or lysosomes of a range of cancer cell lines, including human cervical cancer HeLa cells, hepatocellular carcinoma HepG2 cells, breast cancer MCF-7 cells an ...
DOI:
10.1039/c8tb00593a

23. Green synthesis of SnO2 quantum dots using Parkia speciosa Hassk pods extract for the evaluation of anti-oxidant and photocatalytic properties

Author:
Shamima Begum; Md. Ahmaruzzaman
Source:
Journal of photochemistry and photobiology 2018 v.184 pp. 44-53
ISSN:
1011-1344
Subject:
2,2-diphenyl-1-picrylhydrazyl; Fourier transform infrared spectroscopy; Parkia speciosa; X-ray diffraction; antioxidants; aqueous solutions; biosynthesis; energy-dispersive X-ray analysis; food colorants; free radicals; inhibitory concentration 50; irradiation; pH; photocatalysis; photocatalysts; photolysis; pods; quantum dots; tin dioxide; transmission electron microscopy
Abstract:
... In the present study, microwave heating method was established for the biosynthesis of SnO2 Quantum dots (QDs) using Parkia speciosa Hassk pods extract. The as-synthesized quantum dots have been characterized by various techniques such as UV, XRD, EDX, TEM, HRTEM, SAED and FTIR spectroscopy. The biosynthesized SnO2 QDs was employed for the first time as an efficient photocatalyst for the degradati ...
DOI:
10.1016/j.jphotobiol.2018.04.041

24. Hierarchically designed hybrid nanoparticles for combinational photochemotherapy against a pancreatic cancer cell line

Author:
F. Joubert; G. Pasparakis
Source:
Journal of materials chemistry 2018 v.6 no.7 pp. 1095-1104
ISSN:
2050-7518
Subject:
cell lines; chemistry; cytotoxicity; inhibitory concentration 50; irradiation; nanogold; nanoparticles; neoplasm cells; pancreatic neoplasms; photochemotherapy; polymers; surface plasmon resonance; synergism; wavelengths
Abstract:
... Here, we report the formulation of hybrid nanoparticles consisting of aggregated gold nanoparticles (GNPs) impregnated into a gemcitabine–polymer conjugate matrix that exhibit synergistic photo-chemo-therapeutic activity against pancreatic cancer. Well-defined, sub-100 nm hybrid NPs were successfully formulated and their photothermal conversion efficiency was evaluated, which was found to be as hi ...
DOI:
10.1039/c7tb03261g

25. IR 780-loaded hyaluronic acid micelles for enhanced tumor-targeted photothermal therapy

Author:
Saji Uthaman; Ansuja Pulickal Mathew; Hyeong Ju Park; Byeong-Il Lee; Hyung-Seok Kim; Kang Moo Huh; In-Kyu Park
Source:
Carbohydrate polymers 2018 v.181 pp. 1-9
ISSN:
0144-8617
Subject:
adverse effects; cell death; heart; hyaluronic acid; inhibitory concentration 50; irradiation; kidneys; liver; lungs; micelles; neoplasms; spleen; temperature; therapeutics
Abstract:
... In this study, we propose using IR 780-loaded, CD44-targeted hyaluronic acid-based micelles (HA-IR 780) for enhanced photothermal therapy (PTT) effects in tumors. Two kinds of HA-C18 micelles were synthesized from different C18 feed ratios with degree of substitution of 3% and 13% respectively. Three different IR 780 weight percentages were used for micelle formation with loading content of 4.6%, ...
DOI:
10.1016/j.carbpol.2017.10.033

26. Laser assisted anticancer activity of benzimidazole based metal organic nanoparticles

Author:
P.A. Praveen; R. Ramesh Babu; P. Balaji; A. Murugadas; M.A. Akbarsha
Source:
Journal of photochemistry and photobiology 2018 v.180 pp. 218-224
ISSN:
1011-1344
Subject:
absorption; antineoplastic activity; benzimidazole; cell lines; cobalt; copper; energy; fibroblasts; humans; inhibitory concentration 50; irradiation; lung neoplasms; mice; nanoparticles; particle size; phototoxicity; therapeutics; transmission electron microscopy; zeta potential
Abstract:
... Recent studies showed that the photothermal therapy can be effectively used for the targeted cancerous cells destruction. Hence, in the present study, benzimidazole based metal organic complex nanoparticles, dichloro cobalt(II) bis-benzimidazole (Co-BMZ) and dichloro copper(II) bis-benzimidazole (Cu-BMZ), were synthesized by reprecipitation method and their anti-cancer activity by means of phototh ...
DOI:
10.1016/j.jphotobiol.2018.02.008

27. Near-infrared triggered co-delivery of doxorubicin and quercetin by using gold nanocages with tetradecanol to maximize anti-tumor effects on MCF-7/ADR cells

Author:
Zhipeng Zhang; Shaohui Xu; Yun Wang; Yanna Yu; Fangzhou Li; Hao Zhu; Yuanyuan Shen; Shengtang Huang; Shengrong Guo
Source:
Journal of colloid and interface science 2018 v.509 pp. 47-57
ISSN:
0021-9797
Subject:
P-glycoproteins; adenosine triphosphate; antineoplastic activity; biotin; cytotoxicity; doxorubicin; drug therapy; gold; inhibitory concentration 50; irradiation; melting point; micelles; multiple drug resistance; nanocarriers; nanogold; neoplasms; quercetin; synergism
Abstract:
... Previously, combination chemotherapy of doxorubicin (DOX) and quercetin (QUR) was developed to improve antitumor effects and reverse multidrug resistance and several biocompatible nanocarriers, such as liposomes and micelles, were validated for their targeted delivery. In this study, we report a near-infrared (NIR)-responsive drug delivery system based on DOX and QUR co-loaded gold nanocages (AuNC ...
DOI:
10.1016/j.jcis.2017.08.097

28. Photoactivated [Mn(CO)3Br(μ-bpcpd)]2 induces apoptosis in cancer cells via intrinsic pathway

Author:
Vidhyapriya P.; Divya D.; Manimaran Bala; Sakthivel N.
Source:
Journal of photochemistry and photobiology 2018 v.188 pp. 28-41
ISSN:
1011-1344
Subject:
Fourier transform infrared spectroscopy; apoptosis; breasts; carbon monoxide; caspase-3; caspase-9; cell lines; colon; cytotoxicity; flow cytometry; inhibitory concentration 50; irradiation; liquids; lungs; manganese; membrane potential; mitochondrial membrane; myoglobin; neoplasm cells; neoplasms; photochemotherapy; propidium; protein synthesis; spectral analysis; staining; superoxide anion; ultraviolet radiation
Abstract:
... Carbon monoxide releasing molecules (CORMs) are organometallic/organic compounds that release carbon monoxide (CO) spontaneously or upon activation. PhotoCORMs are capable of releasing CO on light based activation. This group of molecules is used in photodynamic therapy due to their ability to release CO in a controlled manner. In the present investigation, the release of CO from [Mn(CO)3Br(μ-bpcp ...
DOI:
10.1016/j.jphotobiol.2018.08.021

29. Photosensitization of Chinese hamster V79 cells to photoactivated alpha-terthienyl involving membrane damage and oxidative stress

Author:
Shaorong Luan; Solange Muhayimana; Jiuyong Xu; Xianfei Zhang; Ciying Xiao; Qingchun Huang
Source:
Journal of photochemistry and photobiology 2018 v.185 pp. 192-198
ISSN:
1011-1344
Subject:
Chinese hamsters; alpha-terthienyl; catalase; cell viability; cytotoxicity; enzyme activity; fibroblasts; inhibitory concentration 50; irradiation; lungs; malondialdehyde; necrosis; oxidative stress; peroxidase; photosensitivity; shrinkage; superoxide dismutase
Abstract:
... Photosensitization of V79 Chinese hamster lung fibroblasts was tested to investigate if the cells can fit the photoactive effect of alpha-terthienyl for safety application. Using 15-min photoirradiation of a black light (320–400 nm, 40 W), alpha-terthienyl was significantly photoactivated and caused V79 cells to be shrinkage, detachment and necrosis. The photoactivated alpha-terthienyl played a co ...
DOI:
10.1016/j.jphotobiol.2018.06.012

30. Protective effect of Thai silk extracts on drug-induced phototoxicity in human epidermal A431 cells and a reconstructed human epidermis model

Author:
Apiwan Rosena; Thongchai Koobkokkruad; Waleewan Eaknai; Phichaporn Bunwatcharaphansakun; Rawiwan Maniratanachote; Sasitorn Aueviriyavit
Source:
Journal of photochemistry and photobiology 2018 v.188 pp. 50-59
ISSN:
1011-1344
Subject:
Bombyx mori; antipsychotics; apoptosis; artificial skin; cell lines; chlorpromazine; degumming; glutathione; humans; inhibitory concentration 50; interleukin-1alpha; irradiation; models; oxidative stress; phototoxicity; protective effect; sericin; silk; textile industry; ultraviolet radiation; viability
Abstract:
... Bombyx mori silk extracts, derived from the cocoon degumming process of draw and dye silk in the textile industry, are mainly composed of sericin protein. To add value to the Thai silk extracts, and hence the silk industry, a simple enrichment process was recently developed and the enriched silk extracts were then applied in nano-cosmeceutical products and nano-delivery systems. In this study, the ...
DOI:
10.1016/j.jphotobiol.2018.08.022

31. Synthesis, characterization, and antitumor activity of some novel S-functionalized benzo[d]thiazole-2-thiol derivatives; regioselective coupling to the –SH group

Author:
El Sayed Ramadan; Hamida M. Abdel Hamid; Sawsan A. Noureddin; Khadija O. Badahdah
Source:
Zeitschrift für Naturforschung 2018 v.73 no.9 pp. 647-654
ISSN:
1865-7117
Subject:
albino; allylation; antibiotics; antineoplastic activity; ascites; bromides; carcinoma; dimethylformamide; doxorubicin; hydrides; inhibitory concentration 50; irradiation; mice; organobromine compounds; regioselectivity; sodium; spectral analysis; thiazoles
Abstract:
... Several 2-substituted sulfanyl benzo[d]thiazoles were regioselectively synthesized by the reaction of benzo[d]thiazole-2-thiol (1a) with a variety of reagents under different basic conditions. Some 2-(2,3-disubstituted propyl sulfanyl)benzo[d]thiazoles were obtained from 2-(allylthio)benzo[d]thiazole, which was prepared by the allylation of 1a with allyl bromide in the presence of sodium hydride i ...
DOI:
10.1515/znb-2018-0078

32. A two-photon-activated prodrug for therapy and drug release monitoring

Author:
Peilian LiuThese authors contributed equally to this work.; Bowen Li; Chenyue Zhan; Fang Zeng; Shuizhu Wu
Source:
Journal of materials chemistry B 2017 v.5 no.36 pp. 7538-7546
ISSN:
2050-7518
Subject:
antineoplastic agents; cytotoxicity; energy transfer; fluorescence; fluorescent dyes; inhibitory concentration 50; irradiation; moieties; monitoring; therapeutics
Abstract:
... A light-activated cleavage strategy for the concomitant release of active drugs and generation of fluorescence changes is highly desirable. Herein a molecular prodrug featuring real-time monitoring of drug localization and release by manipulating fluorophores has been created by constructing a cleavable structure which comprises a photoremovable coumarinyl, an anticancer drug camptothecin, a cleav ...
DOI:
10.1039/c7tb01408b

33. Antioxidative cellular response of lepidopteran ovarian cells to photoactivated alpha-terthienyl

Author:
Qingchun Huang; Xinming Yun; Wenbing Rao; Ciying Xiao
Source:
Pesticide biochemistry and physiology 2017 v.137 pp. 1-7
ISSN:
0048-3575
Subject:
Lepidoptera; alpha-terthienyl; apoptosis; catalase; cell viability; cytotoxicity; inhibitory concentration 50; insect pests; interphase; irradiation; malondialdehyde; oxidative stress; peroxidase; photosensitizing agents; reproduction; superoxide dismutase
Abstract:
... Photodynamic sensitizers as useful alternative agents have been used for population control against insect pests, and the response of insect ovarian cells towards the photosensitizers is gaining attention because of the next reproduction. In this paper, antioxidative responses of lepidopteran ovarian Tn5B1-4 and Sf-21 cells to photoactivated alpha-terthienyl (PAT) are investigated. PAT shows posit ...
DOI:
10.1016/j.pestbp.2016.09.006

34. Byrsonima crassifolia extract and fraction prevent UVB-induced oxidative stress in keratinocytes culture and increase antioxidant activity on skin

Author:
Rebeca Oliveira de Souza; Geórgia de Assis Dias Alves; Ana Luiza Scarano Aguillera Forte; Franciane Marquele-Oliveira; Daniele Fernandes da Silva; Hervé Rogez; Maria José Vieira Fonseca
Source:
Industrial crops and products 2017 v.108 pp. 485-494
ISSN:
0926-6690
Subject:
2,2-diphenyl-1-picrylhydrazyl; Byrsonima crassifolia; antioxidant activity; catechin; cell culture; chemiluminescence; ears; inhibitory concentration 50; interleukin-6; irradiation; keratinocytes; leaf extracts; lipid peroxidation; oxidative stress; secretion; skin lesions; swine; topical application; traditional medicine; transcription factor NF-kappa B; tumor necrosis factor-alpha; ultraviolet radiation; xanthine
Abstract:
... Solar ultraviolet radiation exposure, particularly UVB rays (280–320nm), can lead to skin lesions, photocarcinogenesis and acceleration of skin photoaging since UVB radiation may reach both the epidermal and dermal layers of the skin. Treatments that can ameliorate UVB-induced skin damage include natural extracts, which can act as skin photochemoprotective agents. Byrsonima crassifolia is widely u ...
DOI:
10.1016/j.indcrop.2017.07.015

35. Compounds isolated from Eriobotrya deflexa leaves protect against ultraviolet radiation B-induced photoaging in human fibroblasts

Author:
Chung-Yu Huang; Yi-Tzu Lin; Hsiang-Chun Kuo; Wen-Fei Chiou; Mei-Hsien Lee
Source:
Journal of photochemistry and photobiology 2017 v.175 pp. 244-253
ISSN:
1011-1344
Subject:
Eriobotrya deflexa; active ingredients; bioactive properties; butanol; collagen; ethanol; ethyl acetate; fibroblasts; free radical scavengers; hexane; humans; hydroxyl radicals; inhibitory concentration 50; irradiation; leaf extracts; leaves; liquid chromatography; mass spectrometry; metalloproteinases; photoaging; quercetin; spectral analysis; traditional medicine; ultraviolet radiation; Taiwan
Abstract:
... Ultraviolet (UV) irradiation leads to skin photoaging because of the upregulation of matrix metalloproteinase (MMP)-1 and downregulation of type I collagen and tissue inhibitor of metalloproteinase (TIMP)-1. Eriobotrya deflexa (Hemsl.) Nakai (Rosaceae) is a flowering plant endemic to Taiwan, and its leaves have been used as an expectorant and in antitussive folk remedy. Our previous studies have d ...
DOI:
10.1016/j.jphotobiol.2017.08.042

36. Conjugate of biotin with silicon(IV) phthalocyanine for tumor-targeting photodynamic therapy

Author:
Ke Li; Ling Qiu; Qingzhu Liu; Gaochao Lv; Xueyu Zhao; Shanshan Wang; Jianguo Lin
Source:
Journal of photochemistry and photobiology 2017 v.174 pp. 243-250
ISSN:
1011-1344
Subject:
binding capacity; biotin; fluorescence; hepatocytes; human cell lines; humans; inhibitory concentration 50; irradiation; neoplasm cells; photochemotherapy; photosensitizing agents; receptors; silicon; toxicity; uterine cervical neoplasms
Abstract:
... In order to improve the efficacy of photodynamic therapy (PDT), biotin was axially conjugated with silicon(IV) phthalocyanine (SiPc) skeleton to develop a new tumor-targeting photosensitizer SiPc-biotin. The target compound SiPc-biotin showed much higher binding affinity toward BR-positive (biotin receptor overexpressed) HeLa human cervical carcinoma cells than its precursor SiPc-pip. However, whe ...
DOI:
10.1016/j.jphotobiol.2017.08.003

37. Cytotoxic and antibacterial activities of iridoids and sesquiterpenoids from Valeriana jatamansi

Author:
Ying-Hong Liu; Pei-Qian Wu; Qiao-Ling Hu; Yue-Juan Pei; Feng-Ming Qi; Zhan-Xin Zhang; Dong-Qing Fei
Source:
Fitoterapia 2017 pp. -
ISSN:
0367-326X
Subject:
Pseudomonas aeruginosa; Staphylococcus aureus; Valeriana jatamansi; X-ray diffraction; antibacterial properties; bacteria; cytotoxicity; inhibitory concentration 50; iridoids; irradiation; medicinal plants; neoplasms; nuclear magnetic resonance spectroscopy; roots; sesquiterpenoids; spectral analysis
Abstract:
... Three new iridoids, valejatanins A–C (1–3), and one new natrual iridoid (4), together with four known sesquiterpenoids (5–8), were isolated from the roots of Valeriana jatamansi Jones. Compounds 3 and 4 are C(4)-epimers. Their structures were elucidated by extensive spectroscopic analysis (IR, HRESIMS, 1D and 2D NMR) and by comparison of their NMR data with those of related compounds. The absolute ...
DOI:
10.1016/j.fitote.2017.09.011

38. Nanohybrid magnetic liposome functionalized with hyaluronic acid for enhanced cellular uptake and near-infrared-triggered drug release

Author:
Van Du Nguyen; Shaohui Zheng; Jiwon Han; Viet Ha Le; Jong-Oh Park; Sukho Park
Source:
Colloids and surfaces 2017 v.154 pp. 104-114
ISSN:
0927-7765
Subject:
antineoplastic agents; aqueous solutions; breast neoplasms; colloids; coumarin; drug therapy; gene overexpression; humans; hyaluronic acid; hydrophobicity; inhibitory concentration 50; irradiation; nanoparticles; neoplasm cells; polymers; staining
Abstract:
... The aim of this work is to prepare and evaluate a novel lipid-polymer hybrid liposomal nanoplatform (hyaluronic acid-magnetic nanoparticle-liposomes, HA-MNP-LPs) as a vehicle for targeted delivery and triggered release of an anticancer drug (docetaxel, DTX) in human breast cancer cells. We first synthesize an amphiphilic hyaluronic acid hexadecylamine polymer (HA-C16) to enhance the targeting abil ...
DOI:
10.1016/j.colsurfb.2017.03.008

39. Passiflora tarminiana fruits reduce UVB-induced photoaging in human skin fibroblasts

Author:
Karent Bravo; Luisa Duque; Federico Ferreres; Diego A. Moreno; Edison Osorio
Source:
Journal of photochemistry and photobiology 2017 v.168 pp. 78-88
ISSN:
1011-1344
Subject:
dermis; inhibitory concentration 50; fruits; humans; fibroblasts; glycosylation; procyanidins; anti-aging properties; Passiflora; reactive oxygen species; collagen; flavonoids; collagenase; irradiation; antioxidant activity; ultraviolet radiation; photoaging; South America
Abstract:
... Skin aging is a complex process that is strongly affected by UV radiation, which stimulates the production of reactive oxygen species (ROS) in the epidermis and dermis and subsequently causes skin damage. Among the major consequences are increased collagen degradation and reduced collagen synthesis. Previous reports have demonstrated the beneficial effects of polyphenols for healthy skin. Passiflo ...
DOI:
10.1016/j.jphotobiol.2017.01.023

40. Photocatalysis of S-metolachlor in aqueous suspension of magnetic cerium-doped mTiO2 core–shell under simulated solar light

Author:
J. Mermana; P. Sutthivaiyakit; C. Blaise; F. Gagné; S. Charnsethikul; P. Kidkhunthod; S. Sutthivaiyakit
Source:
Environmental science and pollution research international 2017 v.24 no.4 pp. 4077-4092
ISSN:
0944-1344
Subject:
Selenastrum capricornutum; X-radiation; X-ray absorption spectroscopy; absorption; algae; byproducts; carbon; cerium; coatings; cost effectiveness; ethanol; freshwater; growth retardation; half life; inhibitory concentration 50; iron oxides; irradiation; lighting; metolachlor; photocatalysis; photocatalysts; porous media; sol-gel processing; titanium dioxide; toxicity; Canada
Abstract:
... Magnetic cerium-doped mesoporous titanium dioxide was synthesized by combining sol–gel method and calcination using tetrabutanate and ammonium cerium nitrate as precursors and Pluronic P123 as a template coating on iron oxide covered with carbon in ethanol. The magnetic Ce-doped catalyst showed only anatase structure with a slight increase in lattice parameters compared to the undoped catalyst. Th ...
DOI:
10.1007/s11356-016-8151-6

41. Photoinduced ROS regulation of apoptosis and mechanism studies of iridium(iii) complex against SGC-7901 cells

Author:
Cheng Zhang; Shang-Hai Lai; Hui-Hui Yang; De-Gang Xing; Chuan-Chuan Zeng; Bing Tang; Dan Wan; Yun-Jun Liu
Source:
RSC advances 2017 v.7 no.29 pp. 17752-17762
ISSN:
2046-2069
Subject:
Western blotting; apoptosis; autophagy; caspases; cell cycle; cell lines; cytotoxicity; flow cytometry; fluorescence microscopes; inhibitory concentration 50; iridium; irradiation; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; neoplasms; proteins
Abstract:
... A new iridium(iii) complex, [Ir(ppy)₂(FBPIP)]PF₆ (Ir-1), was synthesized and characterized. The cytotoxic activity of this complex against SGC-7901, PC-12, SiHa, HepG2, BEL-7402, A549, HeLa and normal LO2 cells was investigated using the MTT method. The complex showed no cytotoxic activity against the selected cell lines. However, upon irradiation, the complex displayed potent anti-proliferative a ...
DOI:
10.1039/c7ra00732a

42. Phototoxic action of a zinc(II) phthalocyanine encapsulated into poloxamine polymeric micelles in 2D and 3D colon carcinoma cell cultures

Author:
Nicolás Chiarante; María C. García Vior; Josefina Awruch; Julieta Marino; Leonor P. Roguin
Source:
Journal of photochemistry and photobiology 2017 v.170 pp. 140-151
ISSN:
1011-1344
Subject:
adenocarcinoma; antioxidants; apoptosis; caspase-3; cell culture; cell viability; colon; colorectal neoplasms; endoplasmic reticulum; enzyme activity; inhibitory concentration 50; irradiation; mice; micelles; mitochondria; neoplasm cells; photochemotherapy; phototoxicity; zinc
Abstract:
... Photodynamic therapy is emerging as a hopeful method for the treatment of oncological diseases. In the search of novel therapeutic strategies for colorectal cancer, in this work we reported the photocytotoxic activity of a lipophilic zinc(II) phthalocyanine on a murine colon adenocarcinoma cell line (CT26 cells). The 2,9(10),16(17),23(24) tetrakis[(2-dimethylamino)ethylsulfanyl]phthalocyaninatozin ...
DOI:
10.1016/j.jphotobiol.2017.04.009

43. Ultrasound assisted, VOSO4 catalyzed Synthesis of 4-thiazolidinones: Antimicrobial Evaluation of indazole-4-thiazolidinone derivatives

Author:
Srinivas Angapelly; P.V. Sri Ramya; Routhu SunithaRani; C. Ganesh Kumar; Ahmed Kamal; Mohammed Arifuddin
Source:
Tetrahedron letters 2017 pp. -
ISSN:
0040-4039
Subject:
antibacterial properties; biofilm; catalysts; catalytic activity; chemical reactions; chemical structure; inhibitory concentration 50; irradiation; organic compounds; ultrasonics
Abstract:
... A simple and expedient multicomponent protocol was developed to synthesize 4-thiazolidinones by employing VOSO4 as a catalyst under ultrasonic irradiation. The significant features of this protocol includes shorter reaction time, high yields, low catalyst loading, and also the catalyst can be recovered and reused up to next four cycles without significant loss in catalytic activity. All the synthe ...
DOI:
10.1016/j.tetlet.2017.10.070

44. An autoreduction method to prepare plasmonic gold-embedded polypeptide micelles for synergistic chemo-photothermal therapy

Author:
Xingjie Wu; Linzhu Zhou; Yue Su; Chang-Ming Dong
Source:
Journal of materials chemistry B 2016 v.4 no.12 pp. 2142-2152
ISSN:
2050-7518
Subject:
absorption; atomic force microscopy; biodegradability; chemical bonding; diodes; doxorubicin; flow cytometry; fluorescence microscopy; gold; inhibitory concentration 50; irradiation; micelles; nanoparticles; near infrared radiation; neoplasm cells; neoplasms; photochemotherapy; photostability; photothermotherapy; polypeptides; reducing agents; staining; synergism; transmission electron microscopy
Abstract:
... Biodegradable, biocompatible polypeptide micelles were used as a reducing agent and template in an autoreduction method for preparing plasmonic gold-embedded polypeptide micelles under mild conditions. The micelles were fully characterized by DLS, TEM, SEM, and AFM. The in situ reduced gold was embedded in the interior core of the disulfide bond-cross-linked polypeptide micelles by forming multiva ...
DOI:
10.1039/c6tb00198j

45. Cationic Oligo(thiophene ethynylene) with Broad-Spectrum and High Antibacterial Efficiency under White Light and Specific Biocidal Activity against S. aureus in Dark

Author:
Zhao Qi; Li Junting; Zhang Xiaoqian; Li Zhengping; Tang Yanli
Source:
ACS applied materials 2016 v.8 no.1 pp. 1019-1024
ISSN:
1944-8252
Subject:
Escherichia coli; Ralstonia solanacearum; Staphylococcus aureus; Staphylococcus epidermidis; antibacterial properties; bacteria; biocides; biocompatibility; cell membranes; cytotoxicity; inhibitory concentration 50; irradiation; lighting; photochemotherapy; singlet oxygen; thiophene; white light
Abstract:
... We designed and synthesized a novel oligo(thiophene ethynylene) (OTE) to investigate the antibacterial activities against Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and Gram-negative (Ralstonia solanacearum and Escherichia coli) bacteria in vitro by photodynamic therapy (PDT). Notably, OTE presents broad-spectrum and greatly high antibacterial activities after white light ...
DOI:
10.1021/acsami.5b11264

46. Cationic porphyrin@SPION nanospheres as multifunctional anticancer therapeutics: magnetic targeting, photodynamic potential and bio-safety research

Author:
Ping Zhao; Min-Chao Liu; Thushara W. Madanayake; Chawla Reena; Min Zheng; Zhen-Feng Cheng; Yu-Min Huang; Xia-Hong Wang
Source:
RSC advances 2016 v.6 no.105 pp. 103137-103148
ISSN:
2046-2069
Subject:
antineoplastic agents; drug design; human cell lines; inhibitory concentration 50; iron oxides; irradiation; light; magnetic fields; nanoparticles; nanospheres; neoplasms; pH; photosensitivity; porphyrins
Abstract:
... The synthesis and characterization of carboxyl-functionalized superparamagnetic iron oxide nanoparticles (SPION)-attached cationic porphyrins with different positive charges (porphyrin@SPION) are described as pH-sensitive, multifunctional photosensitization. These nanospheres exhibit excellent targeted cell accumulation under external magnetic field and outstanding cell photocytotoxicity in weak a ...
DOI:
10.1039/c6ra19697g

47. Co-Delivery of Cisplatin Prodrug and Chlorin e6 by Mesoporous Silica Nanoparticles for Chemo-Photodynamic Combination Therapy to Combat Drug Resistance

Author:
Zhang Wei; Shen Jianliang; Su Hua; Mu Ge; Sun Jing-Hua; Tan Cai-Ping; Liang Xing-Jie; Ji Liang-Nian; Mao Zong-Wan
Source:
ACS Applied Materials & Interfaces 2016 v.8 no.21 pp. 13332-13340
ISSN:
1944-8252
Subject:
antineoplastic activity; chlorins; cisplatin; drug delivery systems; drug resistance; endocytosis; inhibitory concentration 50; irradiation; lung neoplasms; nanoparticles; neoplasm cells; photochemotherapy; photosensitizing agents; porous media; reactive oxygen species; silica
Abstract:
... Combination therapy shows great promise in circumventing cisplatin resistance. We report herein the development of a novel nanoscale drug delivery system (nDDS) based nanotherapeutic that combines chemotherapy and photodynamic therapy (PDT) into one single platform to achieve synergistic anticancer capacity to conquer cisplatin resistance. Mesoporous silica nanoparticle (MSNs) was used as the drug ...
DOI:
10.1021/acsami.6b03881

48. Design, synthesis and in vitro evaluation of anticancer and antibacterial potential of surface modified Tb(OH)₃@SiO₂ core–shell nanoparticles

Author:
Shahanavaj Khan; Anees A. Ansari; Abdul Arif Khan; Wael Al-Kattan; Omar Al-Obeed; Rehan Ahmad
Source:
RSC advances 2016 v.6 no.22 pp. 18667-18677
ISSN:
2046-2069
Subject:
Gram-positive bacteria; Western blotting; antibacterial properties; apoptosis; biocompatibility; colorectal neoplasms; cytotoxicity; erythrocytes; genes; hemolysis; in vitro studies; inhibitory concentration 50; irradiation; nanoparticles; neoplasm cells; silica; solubility; terbium; therapeutics; transmission electron microscopy; ultraviolet radiation; viability
Abstract:
... In the current study, we modified the surface of Tb(OH)₃ nanoparticles with a silica layer to enhance their solubility and biocompatibility. Transmission electron microscopy confirmed the improvements in these properties. Tb(OH)₃@SiO₂ core–shell nanoparticles (TS-CSNPs) exhibited a strong green emission peak upon irradiation with ultraviolet light, which originates from the electric-dipole transit ...
DOI:
10.1039/c5ra17906h

49. Dual-stimuli-responsive glycopolymer bearing a reductive and photo-cleavable unit at block junction

Author:
Jia-You Fang; Yin-Ku Lin; Shiu-Wei Wang; Yung-Ching Yu; Ren-Shen Lee
Source:
RSC advances 2016 v.6 no.109 pp. 107669-107682
ISSN:
2046-2069
Subject:
Lewis bases; aqueous solutions; human cell lines; hydrodynamics; hydrophilicity; hydrophobicity; inhibitory concentration 50; irradiation; lectins; micelles; nanoparticles; polymerization; polymers; reducing agents; sugars; toxicity; ultraviolet radiation
Abstract:
... New dual-stimuli-responsive and bio-recognizable glycopolymers (Glyco-ONB-s-s-PXCL) containing a photodegradable 5-hydroxy-2-nitrobenzyl alcohol (ONB), and a redox-cleavable disulfide (-s-s-) as junction point between bio-recognizable hydrophilic sugar molecule (Glyco) and hydrophobic poly(4-substituted-ε-caprolactone) (PXCL) chains were synthesized using a combination of ring-opening polymerizati ...
DOI:
10.1039/c6ra22207b

50. Gamma irradiation inhibits browning in ready-to-cook (RTC) ash gourd (Benincasa hispida) during storage

Author:
J. Tripathi; P.S. Variyar
Source:
Innovative food science & emerging technologies 2016 v.33 pp. 260-267
ISSN:
1466-8564
Subject:
Benincasa hispida; food industry; fresh-cut produce; fruits; gamma radiation; inhibitory concentration 50; irradiation; microstructure; oxidation; phenolic compounds; ready-to-cook foods; storage quality; synergism; vegetables
Abstract:
... Inhibition of browning in gamma irradiated (2kGy) RTC ash gourd during storage (10°C, 12days) was investigated. Irradiation resulted in a significant increase in the content of α-resorcylic acid that was correlated with decreased PPO activity. Nature of the PPO inhibition was found to be of mixed and reversible type with Ki, 0.09mM; Kis, 27.33mM and IC50 of 25mM. During storage, the non-irradiated ...
DOI:
10.1016/j.ifset.2015.12.005