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1. Analysis and occurrence of matrine in liquorice raw materials - Exclusion of its application as pesticide

Author:
Julia Schultz; Marion Raters; Maximilian Wittig; Birgit Christall; Frank Heckel
Source:
Food additives & contaminants 2022 v.39 no.2 pp. 351-361
ISSN:
1944-0057
Subject:
Sophora; ingredients; licorice; pesticides; raw materials; sweets
Abstract:
... A quick and selective analytical method was developed employing LC-MS/MS for the quantitation of matrine. This is known to be a natural ingredient of Sophora ssp. and is suggested to be a potential contaminant, e.g. in herbal raw materials from liquorice or confectionery products based on liquorice. To prove that the finding of matrine in liquorice roots does not originate from an active use of pe ...
DOI:
10.1080/19440049.2021.2005261

2. Anti-pseudo-allergic components in licorice extract inhibit mast cell degranulation and calcium influx

Author:
Lu WANG; Gui-Zhou HU; Yin LU; Shu-Jun JIANG; Jin QI; Hua SU
Source:
Chinese journal of natural medicines 2022 v.20 no.6 pp. 421-431
ISSN:
1875-5364
Subject:
calcium; chalcone; glycyrrhizin; histamine; humans; leukemia; licorice; ligands; mast cells; mice; rats
Abstract:
... Pseudo-allergic reactions (PARs) widely occur upon application of drugs or functional foods. Anti-pseudo-allergic ingredients from natural products have attracted much attention. This study aimed to investigate anti-pseudo-allergic compounds in licorice. The anti-pseudo-allergic effect of licorice extract was evaluated in rat basophilic leukemia 2H3 (RBL-2H3) cells. Anti-pseudo-allergic compounds ...
DOI:
10.1016/S1875-5364(22)60148-1

3. Bioactive food foams stabilized by licorice extract/whey protein isolate/sodium alginate ternary complexes

Author:
Majid Nooshkam; Mehdi Varidi; Fatemeh Alkobeisi
Source:
Food hydrocolloids 2022 v.126 pp. 107488
ISSN:
0268-005X
Subject:
air; antioxidant activity; cohesion; energy content; firmness; foams; free radicals; gel electrophoresis; hydrocolloids; licorice; particle size; sodium; sodium alginate; surface tension; turbidity; viscoelasticity; viscosity; whey protein isolate
Abstract:
... Interactions among multi-component food matrices play a key role in modulating the foam properties. In this study, foams containing mixtures of sodium alginate (ALG; 0.5, 1.0, and 1.5% w/v), whey protein isolate (WPI; 0.2 and 0.6% w/v), and licorice extract (LE; 0.1, 0.3, and 0.5% w/v) were formed and characterized. The interactions between the components were confirmed by turbidity, ζ-potential, ...
DOI:
10.1016/j.foodhyd.2022.107488

4. Capturing food-elicited emotions: Facial decoding of children’s implicit and explicit responses to tasted samples

Author:
Martina Galler; Åse Riseng Grendstad; Gastón Ares; Paula Varela
Source:
Food quality and preference 2022 v.99 pp. 104551
ISSN:
0950-3293
Subject:
Mentha piperita nothosubsp. piperita; algorithms; case studies; chocolate milk; computer software; fearfulness; flavor; food quality; licorice; observational studies; prediction
Abstract:
... Sensory and consumer research increasingly aims to gain direct input from children to study their eating behaviour. However, answering self-administered questionnaires can be challenging for children. In this sense, the prediction of basic emotions via facial decoding, generating quantitative observational data, could offer an alternative to questionnaires. The present study aimed to measure child ...
DOI:
10.1016/j.foodqual.2022.104551

5. Chemical analysis and flavour compound changes of vegetable blend slurry fermented with selected probiotic bacteria

Author:
Shu Wen Sew; Yuyun Lu; Fransisca Taniasuri; Shao Quan Liu
Source:
Food bioscience 2022 v.47 pp. 101784
ISSN:
2212-4292
Subject:
Allium sativum; Aloe vera; Bifidobacterium animalis subsp. lactis; Cucurbita pepo; Glycyrrhiza glabra; Lactobacillus acidophilus; Zingiber officinale; chemical analysis; coculture; dietary fiber; fermentation; fiber content; flavor compounds; gallic acid; garlic; ginger; licorice; lipid content; oxygen radical absorbance capacity; probiotics; pumpkins; slurries
Abstract:
... A vegetable blend slurry consisting of aloe vera (Aloe barbadensis miller), garlic (Allium sativum), ginger (Zingiber officinale), liquorice (Glycyrrhiza glabra) and pumpkin seeds (Cucurbita pepo L.) was used as a probiotic medium to evaluate the impact of probiotic fermentation on its chemical composition and flavour compound changes. Two commercial probiotic bacteria, Bifidobacterium animalis su ...
DOI:
10.1016/j.fbio.2022.101784

6. Chemical and sensory aroma typicity of La Mancha Petit Verdot wines

Author:
J.A. Delgado; E. Sánchez-Palomo; M. Osorio Alises; M.A. González Viñas
Source:
Lebensmittel-Wissenschaft + Technologie 2022 v.162 pp. 113418
ISSN:
0023-6438
Subject:
acetates; butyrates; citronellol; cultivars; decanoic acid; fruits; gas chromatography-mass spectrometry; grapes; least squares; leather; licorice; octanoic acid; odors; ovens; sensory evaluation; tobacco
Abstract:
... In this work, the aroma of wines, elaborated across five harvests (2015–2019) from Petit Verdot grape variety cultivated in La Mancha region, was studied by instrumental and sensory analysis in order to characterize the aroma of these wines. Volatile compounds were studied by gas chromatography–mass spectrometry (GC/MS). A total of 77 aroma compounds were identified and quantified in Petit Verdot ...
DOI:
10.1016/j.lwt.2022.113418

7. Chemometric analysis and chemical characterization for the botanical identification of Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata and G. lepidota) using liquid chromatography-quadrupole time of flight mass spectrometry (LC-QToF)

Author:
Bharathi Avula; Ji-Yeong Bae; Amar G. Chittiboyina; Yan-Hong Wang; Mei Wang; Jianping Zhao; Zulfiqar Ali; Josef A. Brinckmann; Jing Li; Charles Wu; Ikhlas A. Khan
Source:
Journal of food composition and analysis 2022 v.112 pp. 104679
ISSN:
0889-1575
Subject:
chemometrics; food composition; licorice; mass spectrometry; multivariate analysis; phenolic compounds; roots; saponins; triterpenoids
Abstract:
... Licorice is obtained from the roots of several species of Glycyrrhiza (Fabaceae), a genus containing about 20 species. The Chinese Pharmacopeia specifies three Glycyrrhiza species (G. glabra, G. uralensis, G. inflata). In an effort to unambiguously differentiate roots of five Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, G. echinata, and G. lepidota), a LC-QToF method integrated with c ...
Handle:
10113/7798369
DOI:
10.1016/j.jfca.2022.104679

8. Chemometric discrimination of the geographical origin of licorice in China by untargeted metabolomics

Author:
Youyuan Lu; Guangda Yao; Xuan Wang; Yang Zhang; Jianjun Zhao; Yong-Jie Yu; Hanqing Wang
Source:
Food chemistry 2022 v.380 pp. 132235
ISSN:
0308-8146
Subject:
algorithms; chemometrics; food chemistry; herbal medicines; licorice; metabolites; metabolomics; prediction; provenance; China
Abstract:
... Licorice is famous as a herbal medicine and food sweetener. This study provided a comprehensive strategy for investigating the quality of licorice based on untargeted metabolomics. A new strategy for identifying metabolite was developed, including fragment ion identification algorithm and ion fusion algorithm. The results showed that it can accurately integrate mass spectra from positive and negat ...
DOI:
10.1016/j.foodchem.2022.132235

9. Chinese herbal formulae defend against Mycoplasma gallisepticum infection

Author:
Ying-jie WANG; Ya-xi LIANG; Fu-li HU; Ying-fei SUN; Meng-yun ZOU; Rong-long LUO; Xiu-li PENG
Source:
Journal of integrative agriculture 2022 pp. -
ISSN:
2095-3119
Subject:
Houttuynia; Mycoplasma gallisepticum; Scutellaria; adhesion; agriculture; body weight; chickens; feed conversion; herbal medicines; histopathology; inflammation; licorice; necrosis; neoplasms; pathogens; poultry industry; respiratory tract diseases; therapeutics; tiamulin
Abstract:
... Mycoplasma gallisepticum HS strain (MG-HS) is a pathogen that causes chronic respiratory disease (CRD) in chicken, which is characterized by host respiratory inflammatory damage, brings huge economic losses to the poultry industry. Recently, emerging Chinese herbal medicines (CHM) have been used to treat CRD. This study was aimed to investigate the preventive and therapeutic effects and their pote ...
DOI:
10.1016/j.jia.2022.07.038

10. Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson’s disease like pathology in Zebrafish

Author:
Qingyu Ren; Xin Jiang; Yam Nath Paudel; Xin Gao; Daili Gao; Pengyu Zhang; Wenlong Sheng; Xueliang Shang; Kechun Liu; Xiujun Zhang; Meng Jin
Source:
Journal of ethnopharmacology 2022 v.292 pp. 115234
ISSN:
0378-8741
Subject:
Danio rerio; Glycyrrhiza glabra; Japan; active ingredients; apoptosis; autophagy; brain; chronic hepatitis B; etiology; gene expression; glycyrrhizin; herbal medicines; interleukin-6; licorice; neuroprotective effect; neurotoxins; nucleoproteins; therapeutics; traditional medicine
Abstract:
... Parkinson’s disease (PD) is the second most devastating age-related neurodegenerative diseases after Alzheimer diseases (AD) and is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra (SN) and aggregation of α-synuclein (α-syn). The precise etiology of PD is not yet fully understood and lacks the disease-modifying therapeutic strategies that could reverse the ongoing neu ...
DOI:
10.1016/j.jep.2022.115234

11. Degradation potential of different lignocellulosic residues by Trichoderma longibrachiatum and Trichoderma afroharzianum under solid state fermentation

Author:
Wanyun Li; Lili Zhao; Xueli He
Source:
Process biochemistry 2022 v.112 pp. 6-17
ISSN:
1359-5113
Subject:
Trichoderma longibrachiatum; cellulose; continuous fermentation; corn straw; crude fiber; economic sustainability; endo-1,4-beta-glucanase; licorice; lignocellulose; liquids; pH; response surface methodology; solid state fermentation; spores; sugar content; temperature
Abstract:
... To achieve an economically viable substitutive strategy for lignocellulosic residues use, cellulose degradation by efficient Trichoderma strains become a key alternative. This study aimed to explore the effects of various cultural conditions on the degradation of different lignocellulosic substrates (corn straw and licorice residues) by Trichoderma longibrachiatum and Trichoderma afroharzianum in ...
DOI:
10.1016/j.procbio.2021.11.011

12. Diprenylated flavonoids from licorice induce death of SW480 colorectal cancer cells by promoting autophagy: Activities of lupalbigenin and 6,8-diprenylgenistein

Author:
Xian Shao; Xiaofei Chen; Ziyu Wang; Cuicui Zhu; Yan Du; Daoquan Tang; Shuai Ji
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115488
ISSN:
0378-8741
Subject:
apoptosis; autophagosomes; autophagy; caspase-3; chloroquine; colorectal neoplasms; cytotoxicity; death; flavonoids; flow cytometry; herbal medicines; licorice; traditional medicine
Abstract:
... Licorice is a well-known herbal medicine, and we previously found that several licorice prenylated flavonoids could cause death of SW480 colorectal cancer cells by promoting autophagy. Given many kinds of prenylated flavonoids in licorice, the activities of other compounds deserve further investigation. In addition, the contribution of isoprenyl groups on the autophagy promotion activities has not ...
DOI:
10.1016/j.jep.2022.115488

13. Eco-friendly ‘ochratoxin A’ control in stored licorice roots – quality assurance perspective

Author:
Tahereh Movahhed Haghighi; Mohammad Jamal Saharkhiz; Mohammadreza Khalesi; Seyyed Sasan Mousavi; Asghar Ramezanian
Source:
Food additives & contaminants 2022 v.39 no.7 pp. 1321-1336
ISSN:
1944-0057
Subject:
Aspergillus; Penicillium; chemical composition; droplet size; essential oils; fungi; high performance liquid chromatography; licorice; ochratoxin A; quality control; relative humidity; temperature; toxicity
Abstract:
... According to toxicity data, ochratoxin A (OTA) is the second most important mycotoxin and is produced by Aspergillus and Penicillium. As a natural antifungal agent, clove essential oil (CEO) is a substance generally recognised as safe (GRAS) and shows strong activity against fungal pathogens. Here, we aimed to investigate the control efficacy of CEO in nano-emulsions (CEN) against OTA production i ...
DOI:
10.1080/19440049.2022.2077460

14. Effects of glycyrrhizic acid on hatchability, growth, and physiological responses of farmed dojo loach (Misgurnus anguillicaudatus) during early life stages

Author:
Shuaitong Li; Jiahong Zou; Xu Wang; Zixi Song; Zhen Xu; Qingchao Wang
Source:
Aquaculture 2022 v.557 pp. 738323
ISSN:
0044-8486
Subject:
Artemia; Misgurnus anguillicaudatus; body length; early development; egg hatchability; egg yolk; eggs; fish; glycyrrhizin; growth performance; larvae; larval development; larviculture; licorice; nutrient transport; phenotype; toxicity
Abstract:
... In aquaculture, herbal extracts have been widely tested in multiple fish species due to their safety, low toxicity, and minimal environmental impacts. However, little information is known about the regulatory roles in fish early life stages. Here in the present study, taking dojo loach as an example, we applied glycyrrhizic acid (GA), the most abundant component in licorice root, both in egg hatch ...
DOI:
10.1016/j.aquaculture.2022.738323

15. Effects of licorice on sex hormones and the reproductive system

Author:
Marianna Minnetti; Dario De Alcubierre; Ilaria Bonaventura; Riccardo Pofi; Valeria Hasenmajer; Maria Grazia Tarsitano; Daniele Gianfrilli; Eleonora Poggiogalle; Andrea M. Isidori
Source:
Nutrition 2022 v.103-104 pp. 111727
ISSN:
0899-9007
Subject:
Glycyrrhiza; chalcones; estrogens; females; gonads; hypertension; isoflavonoids; licorice; males; nutrition
Abstract:
... The potential clinical effects of licorice (Glycyrrhiza spp.) and its extracts have been investigated since ancient times. Whether pseudohyperaldosteronism, with consequent arterial hypertension, is the only endocrine effect produced by licorice is uncertain, and a role in the reproductive system has been proposed. This review aimed to summarize the current knowledge on the pharmacologic effects o ...
DOI:
10.1016/j.nut.2022.111727

16. Effects of roasting conditions on Korean rice wine (Makgeolli) with licorice (Glycyrrhiza uralensis Fischer)

Author:
Yang Ya Li; Kwang Yeon Lee; Hyeon Gyu Lee
Source:
Food science and biotechnology 2022 v.31 no.3 pp. 323-332
ISSN:
1226-7708
Subject:
Glycyrrhiza uralensis; antioxidant activity; biotechnology; flavonoids; ingredients; licorice; rice wines; temperature
Abstract:
... The present study investigated the effect of roasting process (temperature: 150, 180, and 210 °C; time: 10, 20, and 30 min) of licorice on the browning index (BI), total flavonoid content (TFC), and antioxidant activity for ingredient of Makgeolli. The antioxidant activity was measured by assaying DPPH radical scavenging activity (DPPH·IC₅₀) and Trolox equivalent antioxidant capacity (TEAC). In ad ...
DOI:
10.1007/s10068-022-01032-z

17. Effects of silicon application on leaf structure and physiological characteristics of Glycyrrhiza uralensis Fisch. and Glycyrrhiza inflata Bat. under salt treatment

Author:
Zihui Shen; Xiaojiao Cheng; Xiao Li; Xianya Deng; Xiuxiu Dong; Shaoming Wang; Xiaozhen Pu
Source:
BMC plant biology 2022 v.22 no.1 pp. 390
ISSN:
1471-2229
Subject:
Glycyrrhiza inflata; Glycyrrhiza uralensis; cash crops; crop yield; foliar application; gas exchange; leaf area; leaf thickness; leaves; licorice; organic matter; phloem; photosynthesis; plant height; salt stress; silicon; soil salinization; transpiration; water content; water transportation; water uptake; xylem
Abstract:
... BACKGROUND: Soil salinization leads to a significant decline in crop yield and quality, including licorice, an important medicinal cash crop. Studies have proofed that the application of exogenous silicon can significantly improve the ability of licorice to resist salt stress, however, few studies concentrated on the effects of foliar silicon application on the morphology, physiological characteri ...
DOI:
10.1186/s12870-022-03783-7

18. Electrochemical-based quantitative fingerprint evaluation strategy combined with multi-markers assay by monolinear method for quality control of herbal medicine

Author:
Dandan Gong; Xiang Li; Xinrong Liu; Guoxiang Sun; Ping Guo
Source:
Phytomedicine 2022 v.104 pp. 154274
ISSN:
0944-7113
Subject:
electrochemistry; herbal medicines; licorice; quality control; quantitative analysis
Abstract:
... Improving the quality control (QC) criterion of herbal medicine (HM) is an ongoing challenge. A rapid and convenient electrochemical analysis technique is now emerging as a promising application for HM QC. So far, extraction and analysis of the overall electroactive components is a key issue need to be solved to improve its application in integral HM QC. In this work, using compound liquorice tabl ...
DOI:
10.1016/j.phymed.2022.154274

19. Elicitation enhanced the production of bioactive compound and biomass accumulation in callus cultures of Glycyrrhiza glabra L.

Author:
Nancy Jaiswal; Yashodhara Verma; Pragati Misra
Source:
In vitro cellular & developmental biology 2022 v.58 no.3 pp. 427-436
ISSN:
1054-5476
Subject:
Glycyrrhiza glabra; adenine sulfate; antioxidant enzymes; bioactive compounds; biomass production; biotin; callus; callus culture; flavonoids; glycyrrhizin; leaves; licorice; metabolites; phenol; proline; putrescine; salicylic acid; spermidine; spermine
Abstract:
... Licorice (Glycyrrhiza glabra L.), Fabaceae, has a wide range of medicinal properties due to the metabolites found in the plant tissues. Callus cultures from Glycyrrhiza glabra were previously initiated in vitro using leaf as an explant and the current study was designed to examine the possible role of various elicitors (biotin, adenine sulphate, salicylic acid, putrescine, spermine, or spermidine) ...
DOI:
10.1007/s11627-021-10227-8

20. First Report of Anthracnose Leaf Spot Caused by Colletotrichum americae-borealis on Oat in China

Author:
Zhaoyu Wang; Jinlong Chen; Chang Joo Lee
Source:
Plant disease 2022 v.106 no.7 pp. 1997
ISSN:
0191-2917
Subject:
Avena sativa; Colletotrichum; air; alfalfa; anthracnose; chitin synthase; chlorosis; conidia; crude fat; crude protein; culture media; data collection; disease control; disease incidence; disease transmission; ethanol; fungi; genes; greenhouses; histones; leaf spot; leaves; licorice; livestock; loci; mycelium; oats; pathogenicity; pathogens; tubulin; China
Abstract:
... Oat (Avena sativa), an important source of crude protein, fiber, and crude fat needed for livestock, is increasingly being cultivated in China. In August 2020, leaf spots were observed on oat cv. Bayan 7 plants in an experimental field of 3 ha with a disease incidence of 12% and a severity of 20% in Daqiao Town (26.42°N, 103.22°E), Huize County, Yunnan Province, China. Symptoms mainly consisted of ...
DOI:
10.1094/PDIS-10-21-2364-PDN

21. Formulation of Glycyrrhizic Acid-based Nanocomplexes for Enhanced Anti-cancer and Anti-inflammatory Effects of Curcumin

Author:
Jihyeon Song; Jun Yeong Kim; Gayeon You; Yoon Young Kang; Jiwon Yang; Hyejung Mok
Source:
Biotechnology and bioprocess engineering 2022 v.27 no.2 pp. 163-170
ISSN:
1226-8372
Subject:
Glycyrrhiza glabra; aqueous solutions; bioprocessing; biotechnology; blood serum; breast neoplasms; curcumin; glycyrrhizin; humans; hydrophobicity; licorice; macrophages; models; necrosis; rheumatoid arthritis; solubility; sonication; splenomegaly; Michigan
Abstract:
... In this study, nanocomplexes composed of glycyrrhizic acid (GA) derived from the root of the licorice plant (Glycyrrhiza glabra) were formulated for the delivery of curcumin (CUR). Sonication of amphiphilic GA solution with hydrophobic CUR resulted in the production of nanosized complexes with a size of 164.8 ± 51.7 nm, which greatly enhanced the solubility of CUR in aqueous solution. A majority o ...
DOI:
10.1007/s12257-021-0198-7

22. Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine

Author:
Yu Wu; Nannan Li; Tao Zhang; Yanyun Che; Kun Duan; Yuedi Wang; Hui Zhou; Xin Wan; Hongjun Lei; Audrey D Nguyễn; Cristabelle De Souza; Kun Li; Yi Wu; Jiaguo Liu; Deyun Wang
Source:
Poultry science 2022 v.101 no.1 pp. 101549
ISSN:
0032-5791
Subject:
Glycyrrhiza; Newcastle disease; antibodies; blood serum; dose response; flavones; food plants; immunity; interleukin-17; interleukin-2; interleukin-4; licorice; polysaccharides; saponins; spleen; vaccines; water solubility
Abstract:
... Licorice is a medicinal and food plant widely used to treat diseases and produce food additives, because of its unique chemical constituents like polysaccharides, flavones, and saponins. Glycyrrhiza Polysaccharides (GPS-1) are water-soluble neutral polysaccharides extracted from licorice. Currently, GPS-1 is administrated to chickens by gavage every d for 14 d to observe the impact of GPS-1 on the ...
DOI:
10.1016/j.psj.2021.101549

23. Glycyrrhizic Acid against Mycoplasma gallisepticum-Induced Inflammation and Apoptosis Through Suppressing the MAPK Pathway in Chickens

Author:
Yingjie Wang; Lulu Wang; Ronglong Luo; Yingfei Sun; Mengyun Zou; Tengfei Wang; Qiao Guo; Xiuli Peng
Source:
Journal of agricultural and food chemistry 2022 v.70 no.6 pp. 1996-2009
ISSN:
1520-5118
Subject:
Mycoplasma gallisepticum; antibiotics; apoptosis; drug resistance; food chemistry; glycyrrhizin; histopathology; inflammation; licorice; lungs; pathogens; pharmacology; poultry production; protein synthesis; virulence
Abstract:
... Mycoplasma gallisepticum (MG) is the primary pathogen of chronic respiratory diseases (CRDs) in chickens. In poultry production, antibiotics are mostly used to prevent and control MG infection, but the drug resistance and residue problems caused by them cannot be ignored. Glycyrrhizic acid (GA) is derived from licorice, a herb traditionally used to treat various respiratory diseases. Our study res ...
DOI:
10.1021/acs.jafc.1c07848

24. Growth, phytochemical parameters and glycyrrhizin production in licorice (Glycyrrhiza glabra L.) grown in the field with saline water irrigation

Author:
Marjan Sadat Hosseini; Morteza Ebrahimi; Javier Abadía; Saeid Kadkhodaei; Rasoul Amirian
Source:
Industrial crops and products 2022 v.177 pp. 114444
ISSN:
0926-6690
Subject:
Glycyrrhiza glabra; antioxidant enzymes; betaine; biomass; biosynthesis; catechol oxidase; genetic background; glycyrrhizin; irrigation; leaf relative water content; leaves; licorice; peroxidase; phytochemicals; proline; saline water; salinity; salt stress; salt tolerance; secondary metabolites; superoxide dismutase; triterpenoids
Abstract:
... Salinity is a worldwide problem in crops that can be managed using salt-tolerant species. Wild licorice (Glycyrrhiza spp.), a genus of the Fabaceae family that is considered medicinal and contains many secondary metabolites, including the triterpenoid glycyrrhizin, can grow in saline conditions. The effects of irrigating five different field-grown genotypes of Glycyrrhiza glabra with two levels of ...
DOI:
10.1016/j.indcrop.2021.114444

25. History and the immunostimulatory effects of heat-processed licorice root products with or without honey

Author:
Misato Ota; Toshiaki Makino
Source:
Journal of ethnopharmacology 2022 v.292 pp. 115108
ISSN:
0378-8741
Subject:
Glycyrrhiza uralensis; Japan; Oriental traditional medicine; granulocyte colony-stimulating factor; heat; honey; immunostimulants; isomaltose; licorice; molecular weight; pain; secretion; throat; China
Abstract:
... In traditional Chinese medicine, the dried root of Glycyrrhiza uralensis Fisch. (licorice root) is usually used after stir-baked with honey. However, in Japanese traditional Kampo medicine, processed licorice root is prepared by roasting without honey. Aim of the study: We summarized our previous studies on the processed licorice root products to review the effectiveness of the processing for lico ...
DOI:
10.1016/j.jep.2022.115108

26. Important changes in germination, seedling tolerance, and active components content due to drought stress on three licorice (Glycyrrhiza) species

Author:
Yuxuan Han; Zhuoni Hou; Xuemin Zhang; Kaijing Yan; Zongsuo Liang; Qiuling He
Source:
Industrial crops and products 2022 v.175 pp. 114240
ISSN:
0926-6690
Subject:
Glycyrrhiza glabra; Glycyrrhiza inflata; Glycyrrhiza uralensis; active ingredients; antioxidant enzymes; climate change; drought tolerance; energy; enzyme activity; evolutionary adaptation; flavor; food industry; genetic variation; glycyrrhizin; licorice; osmoregulation; seed germination; seedlings; spices; water stress
Abstract:
... Drought stress triggers complex physiological and biochemical responses in plants. Different plant species have also evolved several morphological, physiological, biochemical, cellular, and molecular mechanisms to overcome drought stress conditions. However, genotype-specific response factors associated with drought tolerance and the balanced relationship between active components and stress condi ...
DOI:
10.1016/j.indcrop.2021.114240

27. In vitro growth inhibitory effect of selected 18β-glycyrrhetinic acid esters on Theileriaannulata

Author:
K. Buvanesvaragurunathan; J. Ganesh; S. Nagul Kumar; V. Porchezhiyan; A. Radha; P. Azhahianambi; P. Pandikumar; S. Ignacimuthu
Source:
Experimental parasitology 2022 v.236-237 pp. 108258
ISSN:
0014-4894
Subject:
Theileria annulata; cattle; etiological agents; glycyrrhetinic acid; licorice; parasitology; pharmacodynamics; spectroscopy; theileriosis; toxicity testing
Abstract:
... Glycyrrhetinic acid (GA) is one of the important Pentacyclic Triterpenoids (PT) found in the roots of licorice. This study aimed to evaluate the in vitro growth inhibitory effect of 18β-GA (18β-Glycyrrhetinic acid) and C-30 esters against Theileria annulata, the causative agent of Tropical Bovine Theileriosis. C-30 esters of 18β-GA were synthesized and their structures were elucidated using spectr ...
DOI:
10.1016/j.exppara.2022.108258

28. In-silico screening of potential target transporters for glycyrrhetinic acid (GA) via deep learning prediction of drug-target interactions

Author:
Adham M. Alkhadrawi; Ying Wang; Chun Li
Source:
Biochemical engineering journal 2022 v.181 pp. 108375
ISSN:
1369-703X
Subject:
ABC transporters; Glycyrrhiza; computer simulation; drugs; glycyrrhetinic acid; licorice; prediction; probability
Abstract:
... Glycyrrhetinic acid (GA) is one of the major bioactive components of the leguminous plant Glycyrrhiza spp. (Chinese licorice). The mechanism by which GA is transported within or out of cells remains completely unknown. Given the fact that living organisms harbor thousands of membrane transporters, experimental verification of membrane transporters for specific GA transporters is both laborious and ...
DOI:
10.1016/j.bej.2022.108375

29. Investigation of biochars application on potassium forms and dynamics in a calcareous soil under different moisture conditions

Author:
Mahdi Najafi-Ghiri; Hamid Reza Boostani; Ailsa G. Hardie
Source:
Archiv für Acker- und Pflanzenbau und Bodenkunde 2022 v.68 no.3 pp. 325-339
ISSN:
1476-3567
Subject:
biochar; calcareous soils; cow manure; exchangeable potassium; licorice; potassium; pulp; pyrolysis; water holding capacity
Abstract:
... Biochar due to its high K content may affect K forms and dynamics. The effect of biochars produced from licorice root pulp, municipal waste and cow manure at 300 °C and 600 °C on K forms, release and fixation in a loamy calcareous soil was investigated. The soil samples were analyzed after biochar application and incubation at field water-holding capacity or saturation conditions. The cow manure a ...
DOI:
10.1080/03650340.2020.1834083

30. Involvement of MicroRNA-27a-3p in the Licorice-Induced Alteration of Cd28 Expression in Mice

Author:
Gang Feng; Guozheng Liang; Yaqian Zhang; Jicong Hu; Chuandong Zhou; Jiawen Li; Wenfeng Zhang; Han Shen; Fenglin Wu; Changli Tao; Yan Liu; Hongwei Shao
Source:
Genes 2022 v.13 no.7 pp. -
ISSN:
2073-4425
Subject:
blood serum; gene expression regulation; genes; licorice; microRNA; sequence analysis
Abstract:
... Licorice has previously been shown to affect gene expression in cells; however, the underlying mechanisms remain to be clarified. We analyzed the microRNA expression profile of serum from mice treated by gavage with licorice decoction, and obtained 11 differentially expressed microRNAs (DEmiRNAs). We also screened differentially expressed genes (DEgenes) based on RNA-Seq data, and 271 common genes ...
DOI:
10.3390/genes13071143

31. Is 18α-Glycyrrhizin a real natural product? Improved preparation of 18α-Glycyrrhizin from 18β-Glycyrrhizin as a positive standard for HPLC analysis of licorice extracts

Author:
Kritamorn Jitrangsri; Kazuaki Kamata; Mana Akiba; Yoshie Yajiri; Masami Ishibashi; Jin Tatsuzaki; Tsutomu Ishikawa
Source:
Natural medicines 2022 v.76 no.2 pp. 367-378
ISSN:
1340-3443
Subject:
Glycyrrhiza; alkaline hydrolysis; esterification; glycyrrhizin; licorice; thermodynamics; traditional medicine
Abstract:
... 18α-Glycyrrhizin is an epimer of 18β-glycyrrhizin, a major component of licorice (Glycyrrhiza sp.), which is widely used as a traditional medicine. Whether 18α-glycyrrhizin is a real natural product has been debated in the long history of glycyrrhizin chemistry because 18β-glycyrrhizin is epimerizable to a more thermodynamically stable 18α-glycyrrhizin under aqueous alkali conditions. We improved ...
DOI:
10.1007/s11418-021-01589-9

32. Isoliquiritigenin alleviates diabetic symptoms via activating AMPK and inhibiting mTORC1 signaling in diet-induced diabetic mice

Author:
Lin Yang; Doudou Wang; Zhixin Zhang; Yu Jiang; Ying Liu
Source:
Phytomedicine 2022 v.98 pp. 153950
ISSN:
0944-7113
Subject:
AMP-activated protein kinase; blood glucose; blood serum; chalcone; diet; fatty liver; glucose tolerance; glycogenesis; histology; homeostasis; hyperglycemia; insulin; insulin resistance; intraperitoneal injection; licorice; lipogenesis; mitochondria; noninsulin-dependent diabetes mellitus; rapamycin; streptozotocin
Abstract:
... To determine the effects of isoliquiritigenin (ISL), a chalcone compound isolated from licorice, on type 2 diabetes mellitus (T2DM). 8-week-old C7BL/6 mice were used to establish the T2DM animal model by feeding with high-fat-high-glucose diet (HFD) combined with intraperitoneal injection of streptozotocin. The animals were treated with ISL for 3 weeks. Blood glucose levels, oral glucose tolerance ...
DOI:
10.1016/j.phymed.2022.153950

33. Isoliquiritigenin inhibits non-small cell lung cancer progression via m6A/IGF2BP3-dependent TWIST1 mRNA stabilization

Author:
Yameng Cui; Yulin Wu; Cong Wang; Zuolin Wang; Yanyang Li; Zhansheng Jiang; Wei Zhao; Zhanyu Pan
Source:
Phytomedicine 2022 v.104 pp. 154299
ISSN:
0944-7113
Subject:
anticarcinogenic agents; antineoplastic activity; carcinogenesis; cell proliferation; humans; licorice; lung neoplasms; neoplasm progression; phenotype; quantitative analysis; transcription factors
Abstract:
... N⁶-methyladenosine (m⁶A) has been identified to regulate the tumorigenesis and development of various tumors, including non-small cell lung cancer (NSCLC). Isoliquiritigenin (ISL), derived from the Chinese herb licorice, shows a significant anti-tumor activity on multiple human cancers. However, the role of ISL on NSCLC through m⁶A is still unclear. Here, we investigated the anti-tumor effect of I ...
DOI:
10.1016/j.phymed.2022.154299

34. Isoliquiritigenin-mediated miR-23a-3p inhibition activates PGC-1α to alleviate alcoholic liver injury

Author:
Lu Wang; Lina Kong; Shuai Xu; Xiaohui Wang; Kai Huang; Shuyuan Wang; Jingjing Wu; Changyuan Wang; Huijun Sun; Kexin Liu; Qiang Meng
Source:
Phytomedicine 2022 v.96 pp. 153845
ISSN:
0944-7113
Subject:
Western blotting; bioinformatics; fatty acid metabolism; flavonoids; fluorescent antibody technique; hepatoprotective effect; histopathology; interleukin-6; licorice; lipids; liver; liver diseases; luciferase; quantitative polymerase chain reaction; reactive oxygen species; therapeutics
Abstract:
... Alcoholic liver disease (ALD), one of the most prevalent forms of liver disease, has received wide attention worldwide. However, limited efficient and appropriate therapeutic agents were responded to ALD. Isoliquiritigenin (ISL), a flavonoid isolated from liquorice, possesses multiple pharmacological activities.The current study investigated the hepatoprotective effect of ISL against ALD and furth ...
DOI:
10.1016/j.phymed.2021.153845

35. Licochalcone A inhibits cell growth through the downregulation of the Hippo pathway via PES1 in cholangiocarcinoma cells

Author:
Ke‐dong Xu; Yi Miao; Pan Li; Ping‐ping Li; Jie Liu; Juan Li; Fang Cao
Source:
Environmental toxicology 2022 v.37 no.3 pp. 564-573
ISSN:
1520-4081
Subject:
active ingredients; antioxidants; biogenesis; cancer therapy; carcinogenesis; cell growth; ecotoxicology; humans; licorice; transcription (genetics)
Abstract:
... Overexpression or activation of Yes‐associated protein (YAP) is common in cancer cells. Thus, targeting YAP may be a strategy for cancer therapy. Licochalcone A (LicA) is a primary active compound of licorice root and is known to have medicinal effects, such as antioxidant, antibacterial, antiviral, and anticancer effects. However, the anticancer pharmacological mechanism of LicA has not been inve ...
DOI:
10.1002/tox.23422

36. Licorice extract ameliorates hyperglycemia through reshaping gut microbiota structure and inhibiting TLR4/NF-κB signaling pathway in type 2 diabetic mice

Author:
Yongli Zhang; Yanni Xu; Ling Zhang; Yijun Chen; Tao Wu; Rui Liu; Wenjie Sui; Qiaomei Zhu; Min Zhang
Source:
Food research international 2022 v.153 pp. 110945
ISSN:
0963-9969
Subject:
Bacteroides; Toll-like receptor 4; blood glucose; blood serum; colon; dose response; food research; glycemic effect; hyperglycemia; inflammation; insulin resistance; intestinal microorganisms; licorice; necrosis; neoplasms; noninsulin-dependent diabetes mellitus
Abstract:
... Previous studies suggested that licorice possessed hypoglycemic activity, but its anti-diabetic mechanism has not been clearly illustrated. Herein, we aimed to investigate the hypoglycemic activity and underlying hypoglycemic mechanisms of licorice extract (20, 40, and 80 mg kg⁻¹day⁻¹) in type 2 diabetes mice. The results showed that licorice extract could improve the levels of fasting blood gluco ...
DOI:
10.1016/j.foodres.2022.110945

37. Major Plant in Herbal Mixture Gan-Mai-Da-Zao for the Alleviation of Depression in Rat Models

Author:
Ying-Xiao Li; Kai-Chun Cheng; Chao-Tien Hsu; Juei-Tang Cheng; Ting-Ting Yang
Source:
Plants 2022 v.11 no.3 pp. -
ISSN:
2223-7747
Subject:
Oriental traditional medicine; Ziziphus; calcium oxide; hippocampus; licorice; oral administration; rats; serotonin; sucrose; wheat
Abstract:
... Gan-Mai-Da-Zao (GMDZ) is a well-known product in Chinese traditional medicine and includes three major plants: blighted wheat (Fu Mai), licorice (Gan Cao), and jujube (Da Zao). GMDZ is widely used as an efficacious and well-tolerated prescription for depression in clinics. The present study was designed to investigate the main plant of GMDZ for its antidepressant-like effect using the unpredictabl ...
DOI:
10.3390/plants11030258

38. Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)‐mediated neuroprotection in a rotenone‐induced cellular model of Parkinson's disease by restoring the mTORC1‐AMPK1 axis in autophagic regulation

Author:
Gayathree Karthikkeyan; Santosh Kumar Behera; Shubham Sukerndeo Upadhyay; Ravishankar Pervaje; Thottethodi Subrahmanya Keshava Prasad; Prashant Kumar Modi
Source:
Phytotherapy research 2022 v.36 no.5 pp. 2207-2222
ISSN:
0951-418X
Subject:
Glycyrrhiza glabra; Parkinson disease; autophagy; energy; licorice; mass spectrometry; metabolism; metabolites; metabolomics; models; neuroprotective effect; phytotherapy; research; rotenone; succinic acid; traditional medicine; tricarboxylic acid cycle
Abstract:
... Parkinson's disease (PD) is an age‐associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu, prepared from the dried roots of Glycyrrhiza glabra L. (licorice) in the rotenone‐induced cellular model of PD. Retinoic a ...
DOI:
10.1002/ptr.7449

39. Microbial amelioration of salinity stress in endangered accessions of Iranian licorice (Glycyrrhiza glabra L.)

Author:
Seyyed Sasan Mousavi; Akbar Karami; Mohammad Jamal Saharkhiz; Mohammad Etemadi; Mohammadhossein Ravanbakhsh
Source:
BMC plant biology 2022 v.22 no.1 pp. 322
ISSN:
1471-2229
Subject:
Azotobacter; Glycyrrhiza glabra; antioxidant activity; catechol oxidase; climate change; environmental factors; enzyme activity; licorice; peroxidase; phenylalanine ammonia-lyase; plant height; principal component analysis; salinity; salt stress
Abstract:
... BACKGROUND: Glycyrrhiza glabra L. is a medicinal and industrial plant that has gone extinct due to different abiotic stress caused by climate change. To understand how the plant-associated microorganism can support this plant under salinity, we collected sixteen Iranian accessions of G. glabra L., inoculated their rhizomes with Azotobacter sp. (two levels, bacterial treatments, and no-bacterial tr ...
DOI:
10.1186/s12870-022-03703-9

40. Modification on the length of glucosyl chain in glucosyl steviol glycosides and its effect on product taste quality

Author:
Zijie Wang; Yuying Yuan; Yaxian Liu; Menglei Zhang; Xiao Hua
Source:
European food research & technology 2022 v.248 no.7 pp. 1703-1713
ISSN:
1438-2377
Subject:
cyclomaltodextrin glucanotransferase; food industry; food research; glycosides; glycosylation; licorice; polyphenols; steviol; stevioside; sweetness; taste sensitivity; technology
Abstract:
... The taste quality of steviol glycosides (SG) is highly dependent on the numbers and linkages of glucosyl units connecting to its diterpenoid core. In this work, the transglycosylation of stevioside (ST) catalyzed by cyclodextrin glucanotransferase were optimized initially. At a high conversion rate of ~ 65%, a mixture of ST derivatives was produced by adding 1– 6 glucosyl units to the ST molecule. ...
DOI:
10.1007/s00217-022-03997-x

41. Molecular and structural insights of β-boswellic acid and glycyrrhizic acid as potent SARS-CoV-2 Envelope protein inhibitors

Author:
Syeda Warisul Fatima; Shahenvaz Alam; Sunil K. Khare
Source:
Phytomedicine plus 2022 v.2 no.2 pp. 100241
ISSN:
2667-0313
Subject:
Boswellia; Glycyrrhiza; Internet; Severe acute respiratory syndrome coronavirus 2; antiviral properties; computer software; drug design; fluorescence; glycyrrhizin; licorice; ligands; models; therapeutics; toxicity testing; triterpenoids; viruses
Abstract:
... Over million people have been infected with SARS-CoV-2 virus worldwide, with around 3% reported deaths till date. A few conventional antiviral treatments have been tried to mitigate the coronavirus. However, many alternative therapeutics are being evaluated worldwide. In the present study, we investigated traditional Indian medicinal compounds antiviral potencies as an effective drug for targeting ...
DOI:
10.1016/j.phyplu.2022.100241

42. Monitoring amino acid profile and protein quality of Licorice (Glycyrrhiza glabra L.) under drought stress, silicon nutrition and mycorrhiza inoculation

Author:
Tahereh Movahhed Haghighi; Mohammad Jamal Saharkhiz; Gholamreza Kavoosi; Abolfazl Jowkar
Source:
Scientia horticulturae 2022 v.295 pp. 110808
ISSN:
0304-4238
Subject:
Glycyrrhiza glabra; amino acid composition; biofertilizers; biomass; field capacity; histidine; inoculum; irrigation; irrigation water; licorice; liquid chromatography; lysine; metabolism; mycorrhizae; nutrition; proline; protein value; root inoculation; silicon; solutes; tandem mass spectrometry; valine; water stress
Abstract:
... Abiotic stresses usually trigger plant responses that entail several changes in the metabolism of amino acids. The Glycyrrhiza glabra rhizomes activate integrative biochemical networks in response to water deficit conditions, mycorrhiza inoculation, and silicon application. In the present study, irrigation was performed to make the soil reach 5 different levels of 20, 40, 60, 80, and 100% of field ...
DOI:
10.1016/j.scienta.2021.110808

43. Multi-dimensional "projection" - the impact of abiotic stresses on the content of seven active compounds and expression of related genes in Glycyrrhiza uralensis Fisch

Author:
Yuxuan Han; Zhuoni Hou; Xuemin Zhang; Qiuling He; Zongsuo Liang
Source:
Environmental and experimental botany 2022 v.197 pp. 104846
ISSN:
0098-8472
Subject:
Glycyrrhiza uralensis; abscisic acid; biosynthesis; cadmium; flavonoids; gene expression; hydroponics; licorice; methyl jasmonate; polyethylene glycol; secondary metabolites; sodium chloride; triterpenoids
Abstract:
... Triterpenoids and flavonoids from licorice (Glycyrrhiza uralensis Fisch.) are known to have a wide range of applications in the pharmaceutical, skin care, and food industries. The effects of various types of abiotic stresses and associated phytohormones - polyethylene glycol, sodium chloride, ultraviolet, cadmium, abscisic acid, and methyl jasmonate - on both the content of these secondary metabol ...
DOI:
10.1016/j.envexpbot.2022.104846

44. Mycorrhizal colonization and silicon nutrition mitigates drought stress in Licorice (Glycyrrhiza glabra L.) with morphophysiological and biochemical perspectives

Author:
Tahereh Movahhed Haghighi; Mohammad Jamal Saharkhiz
Source:
Industrial crops and products 2022 v.178 pp. 114650
ISSN:
0926-6690
Subject:
Glycyrrhiza glabra; catalase; climate change; drought; electrolyte leakage; field capacity; licorice; malondialdehyde; nutrition; peroxidase; plant height; silicon; superoxide dismutase; water stress
Abstract:
... Drought has become a global concern due to the climate-change. Here, the effects of Claroiedoglomus etunicatum inoculation (F₁) and without inoculation (F₀) and silicon nutrition (300 mg/L) (Si₁) and no silicon nutrition (Si₀) were evaluated on morphophysiological and biochemical traits in Licorice (Glycyrrhiza glabra L.). The plants were exposed to drought stress (20%, 40%, 60%, 80%, and 100% fie ...
DOI:
10.1016/j.indcrop.2022.114650

45. NiCo2O4 used as a loading material to improve the capacitive performance of nitrogen-doped carbon aerogel

Author:
Hao Li; Liwei Chen; Qianyun Zhou; Di Qiu; Genlin Zhang; Yanyan Dang
Source:
Journal of materials science 2022 v.57 no.26 pp. 12497-12510
ISSN:
0022-2461
Subject:
Oriental traditional medicine; aerogels; biomass; capacitance; carbon; carbonation; electrochemical capacitors; electrodes; freeze drying; licorice; nanosheets; wastes
Abstract:
... Licorice residue, a considerable amount of biomass waste discarded during the excellent extraction process of traditional Chinese medicine every year, is a potential low-cost and green material for the synthesis of porous carbon material. In this work, spinel phase NiCo₂O₄ nanosheets were produced on the licorice residue-derived nitrogen-doped carbon aerogel (LNCA) using simple hydrothermal and ca ...
DOI:
10.1007/s10853-022-07434-y

46. Non-targeted metabolomic analysis of the variations in the metabolites of two genotypes of Glycyrrhiza uralensis Fisch. under drought stress

Author:
Qianqian Zhang; Bingzhen Li; Qing Chen; Youla Su; Ruijuan Wang; Zhihe Liu; Guilin Chen
Source:
Industrial crops and products 2022 v.176 pp. 114402
ISSN:
0926-6690
Subject:
Glycyrrhiza uralensis; abscisic acid; amino acid metabolism; antioxidant enzymes; drought; flavonoids; genotype; glycosylation; jasmonic acid; licorice; metabolites; metabolomics; phospholipids; tryptophan; tyrosine; water shortages; water stress; China
Abstract:
... Drought stress is one of the important abiotic stresses that restrict the growth of plants. Plants acclimatize themselves to the stress by reprogramming their metabolic pathways. Therefore, understanding the metabolic mechanisms of plants is of great importance to meet the challenge of water shortage. Licorice (Glycyrrhiza uralensis Fisch.) is a commonly used herb that is widely distributed around ...
DOI:
10.1016/j.indcrop.2021.114402

47. Nrf2-mediated liver protection by 18β-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3β pathway

Author:
Zhangting Wang; Jiang Ma; Yisheng He; Kai-Kei Miu; Sheng Yao; Chunping Tang; Yang Ye; Ge Lin
Source:
Phytomedicine 2022 v.102 pp. 154162
ISSN:
0944-7113
Subject:
bilirubin; blood serum; drugs; hepatocytes; hepatoprotective effect; hepatotoxicity; histology; humans; licorice; liver; necrosis; oxidative stress; phosphatidylinositol 3-kinase; phosphorylation; poisoning; quantitative polymerase chain reaction; retrorsine; serine; tau-protein kinase
Abstract:
... Misusage of pyrrolizidine alkaloid (PA)-containing plants or unaware intake of PA-contaminated foodstuffs causes thousands of PA poisoning cases in humans. PA intoxication is accompanied by oxidative stress and subsequent extensive hepatocellular damage. Our previous study has demonstrated that 18β-glycyrrhetinic acid (GA), a bioactive constituent of liquorice, prevented PA-induced hepatotoxicity ...
DOI:
10.1016/j.phymed.2022.154162

48. Oral administration of Jinan Red Ginseng and licorice extract mixtures ameliorates nonalcoholic steatohepatitis by modulating lipogenesis

Author:
Daram Yang; Hyuneui Jeong; Seung-Mi Hwang; Jong-Won Kim; Hee-Won Moon; Ye-Eun Lee; Hyo-Bin Oh; Chung-berm Park; Bumseok Kim
Source:
Journal of Ginseng Research 2022 v.46 no.1 pp. 126-137
ISSN:
1226-8453
Subject:
Panax; Western diets; fatty liver; fibrosis; gene expression; inflammation; licorice; lipids; lipogenesis; liver; oral administration; research
Abstract:
... Nonalcoholic steatohepatitis (NASH) is one of the main chronic liver diseases. NASH is identified by lipid accumulation, inflammation, and fibrosis. Jinan Red Ginseng (JRG) and licorice have been widely used because of their anti-inflammatory and hepatoprotective effects. Hence, this study assessed JRG and licorice extract mixtures' effects on NASH progression.Palmitic acid (PA) and the western di ...
DOI:
10.1016/j.jgr.2021.05.006

49. Photocatalytic removal of toxic dyes, liquorice and tetracycline wastewaters by a mesoporous photocatalyst under irradiation of different lamps and sunlight

Author:
M. Mahmoodi; E. Rafiee; S. Eavani
Source:
Journal of environmental management 2022 v.313 pp. 115023
ISSN:
0301-4797
Subject:
absorption; electrochemistry; environmental management; fluorescence; fluorescent lamps; gentian violet; industrial wastewater; irradiation; licorice; methyl orange; pH; photocatalysis; photocatalysts; photoluminescence; photolysis; porous media; rhodamines; solar radiation; tetracycline; toxicity; xenon
Abstract:
... Simple recyclable K₅CoW₁₂O₄₀/TiO₂ was synthesized and used to remove methyl orange, rhodamine B, direct red 16 and crystal violet toxic organic dyes, liquorice industrial wastewater and tetracycline (TC) as an antibiotic. Photoactivity of the catalyst was checked out under irradiation of various lamps (such as 18 W fluorescent, 300 W Xenon, LED and IR lamps). The best efficiency was obtained by fl ...
DOI:
10.1016/j.jenvman.2022.115023

50. Physicochemical and sensory analysis of honeys from eastern Formosa province (Argentina) and its relationship with their botanical origin

Author:
Cabrera M．; Santander E．
Source:
Food chemistry advances 2022 v.1 pp. 100026
ISSN:
2772-753X
Subject:
Astronium; Copernicia; Eugenia uniflora; Prosopis; Schinopsis balansae; amber; color; flora; food chemistry; licorice; odors; pollen; sensory evaluation; Argentina
Abstract:
... This study aimed to analyze honeys from eastern Formosa province, Argentina. Honey samples (n = 96) were collected between 2009 and 2012 and stored in plastic jars until analysis. Pollen and physicochemical analyses were performed taking into account the methodology of Louveaux et al. (1978) and AOAC (1990). A sensory analysis was also carried out by a group of semitrained panelists. The predomina ...
DOI:
10.1016/j.focha.2022.100026

51. Plant-Based Support of Respiratory Health during Viral Outbreaks

Author:
Thirumurugan Rathinasabapathy; Lakshmana Prabu Sakthivel; Slavko Komarnytsky
Source:
Journal of agricultural and food chemistry 2022 v.70 no.7 pp. 2064-2076
ISSN:
1520-5118
Subject:
Andrographis; Bupleurum; Echinacea; Glycyrrhiza; Marrubium; Sambucus; Urtica; Verbascum; Zingiber; food chemistry; influenza; measles; metabolites; mortality; pharmacology; respiratory system; therapeutics; uncertainty
Abstract:
... Respiratory viruses are linked to major epidemic events that have plagued humans through recorded history and possibly much earlier, ranging from common colds, influenza, and coronavirus infections to measles. However, difficulty in developing effective pharmaceutical solutions to treat infected individuals has hindered efforts to manage and minimize respiratory viral outbreaks and the associated ...
DOI:
10.1021/acs.jafc.1c06227

52. Preclinical studies of licorice in ulcerative colitis: A systematic review with meta-analysis and network pharmacology

Author:
Peng-De Lu; Meng-Chen Yuan; Xing-Ping Quan; Jin-Fen Chen; Yong-Hua Zhao
Source:
Journal of ethnopharmacology 2022 v.296 pp. 115444
ISSN:
0378-8741
Subject:
Oriental traditional medicine; antitussive agents; clinical trials; histology; homeostasis; immunomodulators; inflammation; licorice; meta-analysis; microorganisms; models; pain; pharmacology; risk; sample size; spleen; systematic review; therapeutics; ulcerative colitis
Abstract:
... Licorice, as a traditional Chinese herbal medicine, possessing the efficacies of invigorating spleen and replenishing qi, heat-clearing and detoxicating, phlegm-resolving and cough suppressant, relieving spasm and pain, and hamonizing actions of various medicines. The goal of this systematic review, which includes meta-analysis and network pharmacology in preclinical studies, is to investigate the ...
DOI:
10.1016/j.jep.2022.115444

53. Prenylated phenolic compounds from licorice (Glycyrrhiza uralensis) and their anti-inflammatory activity against osteoarthritis

Author:
Lu Zhao; Xiaofei Chen; Xian Shao; Ziyu Wang; Yan Du; Cuicui Zhu; Wei Du; Daoquan Tang; Shuai Ji
Source:
Food & function 2022 v.13 no.2 pp. 795-805
ISSN:
2042-650X
Subject:
Glycyrrhiza uralensis; Oriental traditional medicine; anti-inflammatory activity; chondrocytes; elderly; ethyl acetate; etiology; food additives; inflammation; interleukin-6; licorice; mice; osteoarthritis
Abstract:
... Osteoarthritis is a significant driver of disability in the elderly with increasing prevalence, and inflammation plays a vital role on its etiology. Licorice is commonly used as a traditional Chinese medicine or food additive, and its prenylated phenolic compounds were recently reported to be able to inhibit osteoarthritis with anti-inflammatory activity. In order to explore more anti-osteoarthrit ...
DOI:
10.1039/d1fo03659a

54. Preparation, characterization, pharmacokinetics, and antirenal injury activity studies of Licochalcone A‐loaded liposomes

Author:
Jing Liu; Zhongan Zhu; Yuhang Yang; Michael Adu‐Frimpong; Lin Chen; Hao Ji; Elmurat Toreniyazov; Qilong Wang; Jiangnan Yu; Ximing Xu
Source:
Journal of food biochemistry 2022 v.46 no.1 pp. e14007
ISSN:
0145-8884
Subject:
Oriental traditional medicine; adenine; antioxidant activity; bioavailability; encapsulation; flavonoids; functional foods; intragastric administration; licorice; models; particle size; pharmacodynamics; pharmacokinetics; renal failure; therapeutics; tissue distribution; water solubility; zeta potential
Abstract:
... A liposome of Licochalcone A (LCA‐Liposomes) was purposively prepared to ameliorate the low in vivo availability and efficacy of LCA. Physical characterization of LCA‐Liposomes was carried out mainly by determining particle size, morphology, zeta potential (Z‐potential), and efficiency of LCA encapsulation (EE) via appropriate techniques. Also, the rate of LCA release in vitro and distribution in ...
DOI:
10.1111/jfbc.14007

55. Process optimization for the synthesis of functionalized Au@AgNPs for specific detection of Hg²⁺ based on quality by design (QbD)

Author:
Hui Zhang; Baoling Wang; Xiaoyi Liu; Hongxu Zhang; Jiangyu Yao; Xingchu Gong; Jizhong Yan
Source:
RSC advances 2022 v.12 no.15 pp. 9121-9129
ISSN:
2046-2069
Subject:
Oriental traditional medicine; algorithms; experimental design; licorice; rapid methods
Abstract:
... The current study highlights the advantages of using the quality by design (QbD) approach to synthesise and optimize SERS substrates for the detection of Hg²⁺. Considering that the performance of Au@AgNPs is affected by many factors, Plackett–Burman (PB) experimental design was used to determine the critical process parameters (CPPs) for evaluating the performance of Au@AgNPs. The quantitative rel ...
DOI:
10.1039/d2ra01500e

56. Quality assessment of fried licorice based on fingerprints and chemometrics

Author:
Xiaoyu Fan; Tingting Hong; Qilin Yang; Dilei Wang; Jing Peng; Wuqing Xiao; Xueying Yang; Xiaohong Hu; Chongli Yu; Shouying Du; Jie Bai
Source:
Food chemistry 2022 v.378 pp. 132121
ISSN:
0308-8146
Subject:
chemometrics; discriminant analysis; food chemistry; licorice; mass spectrometry; medicine; models; prediction; traceability; China
Abstract:
... Fried licorice is obtained by frying licorice without using any auxiliary materials, and it is widely used both as food and medicine in China. To explore the influence of licorice origin on the quality of fried licorice, a method based on fingerprinting and chemometrics was developed. Twenty batches of licorice were selected from four locations. The reference chromatograms of each location were es ...
DOI:
10.1016/j.foodchem.2022.132121

57. Recent advances in glycyrrhizin metabolism, health benefits, clinical effects and drug delivery systems for efficacy improvement; a comprehensive review

Author:
Alaa F. Bakr; Ping Shao; Mohamed A. Farag
Source:
Phytomedicine 2022 v.99 pp. 153999
ISSN:
0944-7113
Subject:
COVID-19 infection; Glycyrrhiza glabra; Oriental traditional medicine; antineoplastic activity; antioxidants; antiviral properties; cosmetics; glycyrrhizin; licorice; metabolism; molecular biology; nanomedicine; particle size; saponins; systematic review; triterpenoids; viruses
Abstract:
... Glycyrrhizin (GL) is a major active constituent of licorice root (Glycyrrhiza glabra) that is considered one of the oldest and most frequently employed botanicals in Chinese medicine and worldwide, with most effects attributed to its rich GL content. Structurally, GL a triterpene saponin that is widely used as a flavoring agent in foodstuffs and cosmetics, and also proposed for various clinical ap ...
DOI:
10.1016/j.phymed.2022.153999

58. Regulation of soil micro-foodwebs to root secondary metabolites in cultivated and wild licorice plants

Author:
Yang Liu; Da Li; Hang Gao; Yuhua Li; Weimin Chen; Shuo Jiao; Gehong Wei
Source:
Science of the total environment 2022 v.828 pp. 154302
ISSN:
0048-9697
Subject:
edaphic factors; environmental management; eukaryotic cells; licorice; protists; rhizosphere; secondary metabolites; soil; species diversity
Abstract:
... The diversity of soil eukaryotes and micro-foodwebs are only partially understood. Moreover, how they affect secondary metabolites in plant roots under distinct soil environment is not well elucidated. By combining multiple statistical analyses and network constructions, variations in soil eukaryotic diversity, community assembly processes and potential associations of holistic microbiotas were in ...
DOI:
10.1016/j.scitotenv.2022.154302

59. Resource sustainability and challenges: Status and competitiveness of international trade in licorice extracts under the Belt and Road Initiative

Author:
Yuxuan Han; Xinru Pang; Xuemin Zhang; Ruilian Han; Zongsuo Liang
Source:
Global ecology and conservation 2022 v.34 pp. e02014
ISSN:
2351-9894
Subject:
ecology; international trade; licorice; market share; markets; medicine; pastures; supply balance; sustainable development; China
Abstract:
... Licorice extract is widely used in medicine, food, pasture, and cosmetic industries. Its growing demand and limited wild licorice resources will create a huge gap between supply and demand. In the context of Belt and Road Initiative, a new pattern of international trade in licorice extracts has been formed. This paper analyzes the current situation of global trade of licorice extracts, and uses th ...
DOI:
10.1016/j.gecco.2022.e02014

60. Revisiting liquorice (Glycyrrhiza glabra L.) as anti-inflammatory, antivirals and immunomodulators: Potential pharmacological applications with mechanistic insight.

Author:
Dheeraj Bisht; Mohmmad Rashid; Rajeshwar Kamal Kant Arya; Deepak Kumar; Sushil Kumar Chaudhary; Vijay Singh Rana; Neeraj K. Sethiya
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100206
ISSN:
2667-0313
Subject:
COVID-19 infection; Glycyrrhiza glabra; antiviral agents; databases; immunomodulators; licorice; mechanism of action; medicinal plants; pandemic; respiratory tract diseases; traditional medicine
Abstract:
... Glycyrrhiza glabra L. (G. glabra) commonly known as liquorice is one of the highly exploited and utilized medicinal plant of the world. Since ancient times liquorice is considered as an auspicious and valuable traditional medicine across the world for treatment of various ailments. Several electronic online scientific databases such as Science Direct, PubMed, Scopus, Scifinder, Google Scholar, onl ...
DOI:
10.1016/j.phyplu.2021.100206

61. Screening biofilm eradication activity of ethanol extracts from foodstuffs: potent biofilm eradication activity of glabridin, a major flavonoid from licorice (Glycyrrhiza glabra), alone and in combination with ɛ-poly-L-lysine

Author:
Tadayuki Tsukatani; Rieko Kuroda; Tomoaki Kawaguchi
Source:
World journal of microbiology & biotechnology 2022 v.38 no.2 pp. 24
ISSN:
0959-3993
Subject:
Escherichia coli; Glycyrrhiza glabra; Porphyromonas gingivalis; Pseudomonas aeruginosa; Staphylococcus aureus; Streptococcus mutans; biofilm; biotechnology; colorimetry; ethanol; flavonoids; food additives; licorice; tetrazolium; viability assays
Abstract:
... The ethanol extracts of 155 different foodstuffs containing medicinal plants were investigated for their biofilm eradication activities against pathogenic bacteria. A combined method of a colorimetric microbial viability assay based on reduction of a tetrazolium salt (WST-8) and a biofilm formation technique on the 96-pins of a microtiter plate lid was used to screen the biofilm eradication activi ...
DOI:
10.1007/s11274-021-03206-z

62. Structure–function relationship of licorice (Glycyrrhiza glabra) root extract–xanthan/guar gum mixture in a high sugar content system

Author:
Marieh Mardani; Samira Yeganehzad; Razieh Niazmand
Source:
Journal of the science of food and agriculture 2022 v.102 no.3 pp. 1056-1065
ISSN:
0022-5142
Subject:
Glycyrrhiza glabra; agriculture; air; biopolymers; enthalpy; guar gum; licorice; microstructure; novel foods; porosity; root extracts; saponins; structure-activity relationships; sugar content; surfactants; sweets; water content; xanthan gum
Abstract:
... BACKGROUND: Foam‐gels are one of the most important multicomponent‐model systems in aerated confectionery, and an investigation of their microstructure is desirable. In this research, the structure–function relationship of xanthan gum/guar gum (XG/GG) and licorice (Glycyrrhiza glabra) root extract powder (LEP) was investigated in a high‐sugar medium. Foam‐gel systems were prepared at 4:10% to 8:20 ...
DOI:
10.1002/jsfa.11441

63. Study on the mechanism of Huangqin Decoction on rats with ulcerative colitis of damp-heat type base on mtDNA, TLR4, p-PI3K, p-Akt protein expression and microbiota

Author:
Yongfeng Zheng; Chunhong Liang; Ziwei Li; Jiao Chen; Zhuoping Chen; Yanping Jiang; Qin Dong; Yujie Xiao; Chaomei Fu; Wan Liao; Xing Yuan
Source:
Journal of ethnopharmacology 2022 v.295 pp. 115356
ISSN:
0378-8741
Subject:
Bacteroides; Lactobacillus; Oriental traditional medicine; Paeonia; Scutellaria; Treponema; Ziziphus; adenoma; blood; cell structures; colon; dysentery; fluorescence; heat; histopathology; interleukin-17; interleukin-23; interleukin-6; intestinal microorganisms; licorice; mechanism of action; mitochondrial DNA; pain; protective effect; protein synthesis; quantitative polymerase chain reaction; rats; ulcerative colitis
Abstract:
... Huangqin decoction (HQD), composed of Scutellaria(Huangqin), Peony(Shaoyao), Liquorice(Gancao) and Jujube(Dazao), is a traditional Chinese medicine prescription, originated from treatise on Febrile Diseases, has the functions of clearing heat, stopping benefits and relieving pain. It is the original prescription for treating heat and relieving dysentery, and is commonly used in clinic for diarrhea ...
DOI:
10.1016/j.jep.2022.115356

64. Sustainable isolation of licorice (Glycyrrhiza glabra L.)-based yellow natural colorant for dyeing of bio-mordanted cotton

Author:
Shahid Adeel; Shumaila Kiran; Mazhar Abbas; Fatima Batool; Muhammad Hussaan; Nimra Amin
Source:
Environmental science and pollution research 2022 v.29 no.21 pp. 31270-31277
ISSN:
0944-1344
Subject:
Acacia; Glycyrrhiza glabra; bark; color; cotton; cotton fabric; dyeing; dyes; licorice; mordants; pollution; pomegranates; research; turmeric; ultrasonics
Abstract:
... Sustainability in the utilization of products in all fields particularly food textiles, solar cells, etc. is of prime concern to the global community. In this study, licorice (Glycyrrhiza glabra L.) as a source of herbal-based coloring agent for cotton dyeing has been explored under the influence of ultrasonic (US) waves. Methanolic extract of licorice bark after US treatment for 20 min has shown ...
DOI:
10.1007/s11356-021-18472-5

65. Synergistic mechanism for the bioactivity fortification of licorice by honey

Author:
Shasha Kong; Pengyue Li; Robert Verpoorte; Jia Wang; Chao Zhu; Yuntao Dai; Shilin Chen
Source:
Journal of ethnopharmacology 2022 v.289 pp. 115048
ISSN:
0378-8741
Subject:
bioavailability; flavonoids; fructose; glucose; health promotion; honey; immunostimulants; licorice; medicinal properties; metabolomics; polysaccharides; solvents; sucrose; synergism; thermal stability; traditional medicine
Abstract:
... Honey-processed licorice has been used since ancient times. It was recorded that honey-processing has the effect of improving the immunomodulatory efficacy of licorice, which has been confirmed by modern pharmacological studies. However, it is still unknown why honey-processing can enhance the immunomodulatory activity of licorice. Our previous research demonstrated that honey has natural deep eut ...
DOI:
10.1016/j.jep.2022.115048

66. Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator

Author:
Zhu Zhang; Ken Kin-Lam Yung; Joshua Ka-Shun Ko
Source:
Antioxidants 2022 v.11 no.7 pp. -
ISSN:
2076-3921
Subject:
Glycyrrhiza glabra; autophagy; biochemical pathways; carcinogenesis; chalcone; energy metabolism; homeostasis; licorice; neurodegenerative diseases; organelles; oxidative stress; pancreatic neoplasms; reactive oxygen species; therapeutics
Abstract:
... Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration and cancer, which are closely associated with intracellular signal transducers such as reactive oxygen species (ROS). It has been suggested that ROS is the upstream regulator of autophagy, and that it provides a negative feedback regulation to remove oxidative damage. Defects in the ROS-autophagic redox home ...
DOI:
10.3390/antiox11071349

67. The effects of plastic film mulching and straw mulching on licorice root yield and soil organic carbon content in a dryland farming

Author:
Jianjun Yang; Rongzhu Qin; Xiaopeng Shi; Huihui Wei; Guojun Sun; Feng-Min Li; Feng Zhang
Source:
Science of the total environment 2022 v.826 pp. 154113
ISSN:
0048-9697
Subject:
Glycyrrhiza uralensis; arid lands; carbon sequestration; corn straw; environment; field experimentation; glycyrrhizin; licorice; microbial carbon; models; plastic film; plastic film mulches; soil organic carbon
Abstract:
... The increasing worldwide demand for traditional herbs has been met by growing cultivated herbs. It is undoubtedly very important to seek a reasonable cultivation mode for the yield, quality and long-term production stability of traditional herbs. In this study, licorice (Glycyrrhiza uralensis Fisch.) was investigated using a field experiment and a process-based model (Denitrification-Decomposition ...
DOI:
10.1016/j.scitotenv.2022.154113

68. The licorice flavonoid isoliquiritigenin attenuates Mycobacterium tuberculosis-induced inflammation through Notch1/NF-κB and MAPK signaling pathways

Author:
Jinxia Sun; Qingwen Zhang; Guizhen Yang; Yinhong Li; Yan Fu; Yuejuan Zheng; Xin Jiang
Source:
Journal of ethnopharmacology 2022 v.294 pp. 115368
ISSN:
0378-8741
Subject:
Mycobacterium tuberculosis; Oriental traditional medicine; Western blotting; adjuvants; antioxidants; cell viability; drugs; enzyme-linked immunosorbent assay; flavonoids; fluorescent antibody technique; inducible nitric oxide synthase; inflammasomes; inflammation; interleukin-6; licorice; macrophages; mice; phosphorylation; prostaglandin synthase; reverse transcriptase polymerase chain reaction; rhizomes; secretion; tuberculosis
Abstract:
... The genus Glycyrrhiza is a small perennial herb that has been traditionally used to treat many diseases across the world. Licorice (Gancao in Chinese) is the dried root and rhizome of G. glabra, G. uralensis or G. inflata. Licorice plays an important role in traditional Chinese medicine (TCM), and is the most frequently used in Chinese herbal formulas. Isoliquiritigenin (ISL) is a flavonoid extrac ...
DOI:
10.1016/j.jep.2022.115368

69. A novel method for vacuum belt drying process optimization of licorice

Author:
Qilong Xue; Kunhong Miao; Yang Yu; Zheng Li
Source:
Journal of food engineering 2022 v.328 pp. 111075
ISSN:
0260-8774
Subject:
decision making; energy; evaporation; licorice; prediction; simulation models; wastes; water content
Abstract:
... A novel prediction method was developed to optimize the operating parameters of the vacuum belt drying (VBD) process of licorice extract. A numerical simulation model containing the boiling and evaporation models was firstly established to predict the product moisture of the process. To improve the accuracy of the numerical simulation, a transition model connecting the boiling and evaporation proc ...
DOI:
10.1016/j.jfoodeng.2022.111075

70. The planting of licorice increased soil microbial diversity and affected the growth and development of apple trees

Author:
Xiaolong Li; Haiying Yue; Yannan Chu; Yonghua Jia; Jianwen Tian
Source:
Communications in soil science and plant analysis 2022 v.53 no.9 pp. 1113-1125
ISSN:
1532-2416
Subject:
Chloroflexi; Gemmatimonadetes; apples; fruit trees; fruit yield; fungi; genes; grasses; growth and development; licorice; nitrogen; orchard soils; phosphorus; plant analysis; potassium; soil bacteria; soil management; soil organic matter; soil quality; tree growth; China
Abstract:
... Grass cultivation is an important soil management practice for improving orchard soil quality. A suitable grass variety can enhance the soil microenvironment and increase fruit yield and quality. In the arid regions of northwestern China, licorice is often planted between apple trees. To clarify the effects of licorice on the soil microenvironment and apple tree growth and development,apple trees ...
DOI:
10.1080/00103624.2022.2043342

71. A trinity fingerprint evaluation system of traditional Chinese medicine

Author:
Huizhi Yang; Ting Yang; Dandan Gong; Xiaohui Li; Guoxiang Sun; Ping Guo
Source:
Journal of chromatography 2022 v.1673 pp. 463118
ISSN:
0021-9673
Subject:
Glycyrrhiza glabra; Oriental traditional medicine; antioxidants; bioactive properties; glycyrrhizin; licorice; quantitative analysis; vibration
Abstract:
... This study focused on developing a set of quality evaluation methods that can reflect the multi-levels and multi-characteristics of traditional Chinese medicine (TCM). Taking licorice (Glycyrrhiza glabra L.) as the method development sample, the feasibility of multi-markers assay by monolinear method (MAML) was explored through the standard curve relationship among active components for the first ...
DOI:
10.1016/j.chroma.2022.463118

72. 18β‐glycyrrhetinic acid improves high‐intensity exercise performance by promoting glucose‐dependent energy production and inhibiting oxidative stress in mice

Author:
Xuan Ma; Hui Chen; Lixing Cao; Shuang Zhao; Chong Zhao; Shutao Yin; Hongbo Hu
Source:
Phytotherapy research 2021 v.35 no.12 pp. 6932-6943
ISSN:
0951-418X
Subject:
Western blotting; athletic performance; bioactive compounds; energy; energy metabolism; enzyme-linked immunosorbent assay; exercise; exercise test; fluorescent antibody technique; glucose transporters; glycogen; insulin; licorice; liver; muscles; oxidative stress; phytotherapy; reactive oxygen species; research
Abstract:
... It has been shown that 18β‐glycyrrhetinic acid (18β‐GA), the main bioactive compound of licorice, can modulate oxidative stress and metabolic processes in liver and skin. Given the critical role of oxidative stress and energy metabolism in exercise‐induced fatigue, we hypothesized that 18β‐GA could exert an ergogenic action by inhibiting excess reactive oxygen species (ROS) induction and promoting ...
DOI:
10.1002/ptr.7310

73. AMF enhance secondary metabolite production in ashwagandha, licorice, and marigold in a fungi-host specific manner

Author:
Leena Johny; David M. Cahill; Alok Adholeya
Source:
Rhizosphere 2021 v.17 pp. 100314
ISSN:
2452-2198
Subject:
Acaulospora; Claroideoglomus claroideum; Claroideoglomus etunicatum; Glomus hoi; Glycyrrhiza glabra; Rhizophagus irregularis; Tagetes erecta; Withania somnifera; alpha-terthienyl; biosynthesis; crops; glycyrrhizin; host plants; knowledge; licorice; methodology; mycorrhizal fungi; rhizosphere; roots; secondary metabolites; symbiosis
Abstract:
... Strategies to enhance the production of secondary metabolites, derived from medicinal and agriculturally important plants have been the subject of exploration to enable effective utilization of these biorepositories. Through symbiosis, arbuscular mycorrhizal fungi (AMF), modify plant primary and secondary metabolite biosynthesis. The relationship thus offers the opportunity to exploit combinations ...
DOI:
10.1016/j.rhisph.2021.100314

74. Administration of isoliquiritigenin prevents nonalcoholic fatty liver disease through a novel IQGAP2‐CREB‐SIRT1 axis

Author:
Li Zhang; Sheng‐Ye Yang; Feng‐Rong Qi‐Li; Xiao‐Xiao Liu; Wei‐Tao Zhang; Chao Peng; Ping Wu; Ping Li; Pingping Li; Xiaojun Xu
Source:
Phytotherapy research 2021 v.35 no.7 pp. 3898-3915
ISSN:
0951-418X
Subject:
fatty liver; flavonoids; heart; homeostasis; humans; licorice; lipid metabolism; lipid peroxidation; lipids; liver; mass spectrometry; phosphorylation; phosphotransferases (kinases); phytotherapy; proteolysis; proteome; research
Abstract:
... Isoliquiritigenin (ISO) is a flavonoid extracted from the root of licorice, which serves various biological and pharmacological functions including antiinflammatory, antioxidation, liver protection, and heart protection. However, the mechanism of its action remains elusive and the direct target proteins of ISO have not been identified so far. Through cell‐based screening, we identified ISO as a po ...
DOI:
10.1002/ptr.7101

75. Adsorption and self-assembly properties of the plant based biosurfactant, Glycyrrhizic acid

Author:
I.M. Tucker; A. Burley; R.E. Petkova; S.L. Hosking; J. Penfold; R.K. Thomas; P.X. Li; J.R.P. Webster; R. Welbourn; J. Doutch
Source:
Journal of colloid and interface science 2021 v.598 pp. 444-454
ISSN:
0021-9797
Subject:
adsorption; anisotropy; aqueous solutions; biosurfactants; gelation; gels; glycyrrhizin; ingredients; isotropy; licorice; liquid-air interface; micelles; neutron diffraction; neutrons; sorption isotherms; texture; triterpenoid saponins
Abstract:
... There is an increased interest in the use of natural surfactant as replacements for synthetic surfactants due to their biosustainable and biocompatible properties. A category of natural surfactants which are attracting much current interest is the triterpenoid saponins; surface active components found extensively in a wide range of plant species. A wide range of different saponin structures exist, ...
DOI:
10.1016/j.jcis.2021.03.101

76. Analysis of Wear Characteristics of Blade Materials and Glycyrrhiza uralensis

Author:
Yameng Shi; Baoqin Wen; Liqiao Li; Tao Wang; Yang Li; Sixue Ren; Jingbin Li
Source:
Transactions of the ASABE v.64 no.4 pp. 1259-1268
ISSN:
2151-0032
Subject:
Glycyrrhiza uralensis; X-radiation; acid hydrolysis; atomic absorption spectrometry; cork; energy; forage grasses; friction; hydrochloric acid; licorice; oxidation; pyrolysis; spring; steel; surface roughness; thermal stability; thermogravimetry; titration; total Kjeldahl nitrogen; total mixed rations; wood; zero gravity
Abstract:
... HighlightsThe thermal reaction between Glycyrrhiza uralensis and metal was analyzed via thermogravimetry.The wear characteristics of three common blade metals were studied under laboratory conditions.The wear mechanisms on the blades by different parts of Glycyrrhiza uralensis were analyzed.Thermal oxidation and element transfer occurred during the wear of Glycyrrhiza uralensis and metals.Abstract ...
DOI:
10.13031/trans.14442

77. Antioxidant effect of acerola fruit powder, rosemary and licorice extract in caiman meat nuggets containing mechanically separated caiman meat

Author:
Gilmar Borges de Paiva; Marco Antonio Trindade; Javier Telis Romero; Andrea Carla da Silva-Barretto
Source:
Meat science 2021 v.173 pp. 108406
ISSN:
0309-1740
Subject:
acerolas; antioxidant activity; antioxidants; cohesion; color; frozen storage; isoascorbic acid; licorice; meat; meat science; rosemary; sensory evaluation; storage time
Abstract:
... The aim of this work was to evaluate the antioxidant effect of acerola fruit powder, rosemary and licorice extract in caiman meat nuggets containing high amounts of mechanically separated caiman meat (MSCM) during 120 days of frozen storage. Five treatments were prepared: a control without antioxidant (CON), sodium erythorbate at 500 mg/kg (ERY), acerola fruit powder at 500 mg/kg (AFP), with licor ...
DOI:
10.1016/j.meatsci.2020.108406

78. Application of Ultrasound and Natural Deep Eutectic Solvent for the Extraction of Glycyrrhizic Acid from Glycyrrhiza glabra: Optimization and Kinetic Evaluation

Author:
Kavita J. Lanjekar; Virendra K. Rathod
Source:
Industrial & engineering chemistry process design and development 2021 v.60 no.26 pp. 9532-9538
ISSN:
1520-5045
Subject:
Glycyrrhiza glabra; acoustics; choline chloride; glycyrrhizin; kinetics; lactic acid; licorice; liquids; process design; solvents; ultrasonic treatment; ultrasonics
Abstract:
... Nowadays, natural deep eutectic solvents (NADESs) are regarded as a green and sustainable substitute to traditional organic solvents for the extraction of bioactive molecules. Similarly, ultrasound-assisted extraction (UAE) is an extensively acknowledged environment-friendly technique due to reduced solvent consumption and extraction time as well as enhanced extraction efficiency as compared to co ...
DOI:
10.1021/acs.iecr.1c00862

79. Application of ultrasound-assisted processing in improving the purification effect and bioactivity of licorice flavonoids from licorice residues

Author:
Zhonghua Luo; Xude Wang; Qingqing Gao; Zhenghong Guo; Wei Li; Yuqing Zhao
Source:
Industrial crops and products 2021 v.167 pp. 113544
ISSN:
0926-6690
Subject:
Glycyrrhiza glabra; adsorption; apoptosis; bioactive compounds; cardiomyocytes; chalcones; desorption; energy density; hydrogen peroxide; licorice; protective effect; purification methods; temperature; ultrasonic treatment
Abstract:
... Licorice residues are rich in flavonoids and are considered to be valuable reusable resources with broad applications and a high economic value. In view of above, the ultrasound-assisted adsorption/desorption of licorice flavonoids (LFs) on HPD-100 resins was studied. This process was studied at different temperatures (20–30 ℃) using ultrasound at different power densities (0.2, 0.35, 0.5 W/cm²). ...
DOI:
10.1016/j.indcrop.2021.113544

80. Assessment of General Toxicity of the Glycyrrhiza New Variety Extract in Rats

Author:
Dong-Gu Kim; Jeonghoon Lee; Wonnam Kim; Hyo-Jin An; Jong-Hyun Lee; Jaeki Chang; Sa-Haeng Kang; Young-Jae Song; Yong-Deok Jeon; Jong-Sik Jin
Source:
Plants 2021 v.10 no.6 pp. -
ISSN:
2223-7747
Subject:
Glycyrrhiza; asthma; cold; cough; dose response; gastritis; hematology; licorice; mortality; new variety; no observed adverse effect level; ophthalmology; oral administration; respiratory system; rural development; toxicology; China; India; Korean Peninsula
Abstract:
... The Glycyrrhiza radix (Licorice) is one of the most commonly used medicinal plants in Asian countries, such as China, India, and Korea. It has been traditionally used to treat many diseases, including cough, cold, asthma, fatigue, gastritis, and respiratory tract infections. A Glycyrrhiza new variety, Wongam (WG), has been developed by the Korea Rural Development Administration and revealed pharma ...
DOI:
10.3390/plants10061126

81. Association analysis and molecular tagging of phytochemicals in the endangered medicinal plant licorice (Glycyrrhiza glabra L.)

Author:
Marjan Sadat Hosseini; Morteza Ebrahimi; Davood Samsampour; Javier Abadía; Morteza Khanahmadi; Rasool Amirian; Iman Naseh Ghafoori; Mostafa Ghaderi-Zefrehei; Yolanda Gogorcena
Source:
Phytochemistry 2021 v.183 pp. 112629
ISSN:
0031-9422
Subject:
Glycyrrhiza glabra; amplified fragment length polymorphism; antioxidants; biodiversity; domestication; endangered species; genetic markers; genetic variation; genotype; glycyrrhizin; licorice; medicinal plants; phenolic compounds; phenotype; phytochemicals; plant breeding; population structure; wild relatives; Iran
Abstract:
... Licorice (Glycyrrhiza glabra L.) is a medicinal plant species valued in many countries in Asia and Europe for its phytochemical characteristics. Licorice biodiversity is becoming threatened nowadays in Iran due to increasing demand and a drastic decline of its natural habitats. Therefore, licorice domestication would be necessary in the near future, and molecular breeding would help to introduce g ...
DOI:
10.1016/j.phytochem.2020.112629

82. Bacillus pumilus improved drought tolerance in Glycyrrhiza uralensis G5 seedlings through enhancing primary and secondary metabolisms

Author:
Xinhui Zhang; Zhicai Xie; Duoyong Lang; Yuankui Chu; Gaochang Cui; Xiaoxia Jia
Source:
Physiologia plantarum 2021 v.171 no.3 pp. 388-399
ISSN:
0031-9317
Subject:
Bacillus pumilus; Glycyrrhiza uralensis; biomass; biosynthesis; drought tolerance; glycyrrhizin; licorice; nitrogen metabolism; plant growth-promoting rhizobacteria; secondary metabolites; sugars; water stress
Abstract:
... It has been reported that drought stress adversely affects the growth and yield of Glycyrrhiza uralensis, Chinese liquorice, in agricultural production. Bacillus pumilus, an important plant growth‐promoting bacterium, play a significant role in improving plant tolerance to abiotic stress. However, the role of Bacillus pumilus G5 in resisting drought stress is largely unknown. In the present study, ...
DOI:
10.1111/ppl.13236

83. Biochar Amendments Improve Licorice (Glycyrrhiza uralensis Fisch.) Growth and Nutrient Uptake under Salt Stress

Author:
Dilfuza Egamberdieva; Hua Ma; Burak Alaylar; Zohreh Zoghi; Aida Kistaubayeva; Stephan Wirth; Sonoko Dorothea Bellingrath-Kimura
Source:
Plants 2021 v.10 no.10 pp. -
ISSN:
2223-7747
Subject:
Glycyrrhiza uralensis; acid phosphatase; biochar; biomass; carbon; corn; drought tolerance; enzyme activity; fluorescein diacetate; legumes; licorice; nitrogen; nodulation; nutrient uptake; phosphorus; plant tissues; proteinases; pyrolysis; root systems; saline soils; salt stress; soil enzymes; surface area
Abstract:
... Licorice (Glycyrrhiza uralensis Fisch.) is a salt and drought tolerant legume suitable for rehabilitating abandoned saline lands, especially in dry arid regions. We hypothesized that soil amended with maize-derived biochar might alleviate salt stress in licorice by improving its growth, nutrient acquisition, and root system adaptation. Experiments were designed to determine the effect of different ...
DOI:
10.3390/plants10102135

84. Biologically guided isolation and ADMET profile of new factor Xa inhibitors from Glycyrrhiza glabra roots using in vitro and in silico approaches

Author:
Reham S. Ibrahim; Rahma S. R. Mahrous; Rasha M. Abu EL-Khair; Samir A. Ross; Abdallah A. Omar; Hoda M. Fathy
Source:
RSC advances 2021 v.11 no.17 pp. 9995-10001
ISSN:
2046-2069
Subject:
COVID-19 infection; Glycyrrhiza glabra; coagulation; computer simulation; formononetin; licorice; naringenin; root extracts; therapeutics
Abstract:
... Selective factor Xa inhibitors effectively block coagulation cascade with a broader therapeutic window than multitargeted anticoagulants. They have evolved as a crucial part of prevention and treatment of thromboembolic diseases and in therapeutic protocols involved in many clinical trials in coronavirus disease 2019 (COVID-19) patients. Biologically-guided isolation of specific FXa inhibitors fro ...
DOI:
10.1039/d1ra00359c

85. Change in the active component of processed Tetradium ruticarpum extracts leads to improvement in efficacy and toxicity attenuation

Author:
Qiyuan Shan; Gang Tian; Juli Wang; Hui Hui; Qiyang Shou; Huiying Fu; Min Hao; Kuilong Wang; Xin Wu; Gang Cao; Guanqun Chen; Luping Qin
Source:
Journal of ethnopharmacology 2021 v.264 pp. 113292
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Tetradium ruticarpum; acute toxicity; alkaloids; amides; analgesics; animal models; anti-inflammatory activity; bioactive compounds; coumarins; essential oils; ethanol; fruits; gas chromatography-mass spectrometry; indoles; licorice; limonoids; manufacturing; medicinal plants; mice; oils; plant extracts; quality control; quinolones; smell; stir frying; ultra-performance liquid chromatography; volatile compounds
Abstract:
... The dried and nearly ripe fruits of Tetradium ruticarpum (A. Juss.) T.G. Hartley (TR) have long been used in treating headache and gastrointestinal disorders in oriental medicine. TR is usually processed by stir-frying with licorice extract before use. Although processing procedure is considered as the way to relieve pungent smell, reduce toxicity, and improve efficacy, its effects on TR's toxicit ...
DOI:
10.1016/j.jep.2020.113292

86. Characterization of polyphenol oxidase from fennel (Foeniculum vulgare Mill.) seeds as a promising source

Author:
Yonca Yuzugullu Karakus; Binnur Yildirim; Arda Acemi
Source:
International journal of biological macromolecules 2021 v.170 pp. 261-271
ISSN:
0141-8130
Subject:
Coriandrum sativum; Foeniculum vulgare; Ziziphus; ascorbic acid; benzoic acid; carob; catechol; catechol oxidase; cysteine; fennel; glutathione; licorice; molecular weight; pH; pyrogallol; sodium metabisulfite; temperature; thiourea
Abstract:
... Fennel seeds were recognized as a promising polyphenol oxidase (PPO) source upon investigating some edible green plants (carob, jujube, coriander, fennel, and licorice). The fennel PPO enzyme was purified by three-phase partitioning and biochemically characterized in detail for the first time. The purification fold and activity recovery values were determined as 20-fold and 120%, respectively. Its ...
DOI:
10.1016/j.ijbiomac.2020.12.147

87. Colonization by dark septate endophytes improves the growth and rhizosphere soil microbiome of licorice plants under different water treatments

Author:
Chao He; Qing Zeng; Yalan Chen; Caixia Chen; Wenquan Wang; Junling Hou; Xianen Li
Source:
Applied soil ecology 2021 v.166 pp. 103993
ISSN:
0929-1393
Subject:
Actinobacteria; Ascomycota; Chloroflexi; Firmicutes; Glycyrrhiza uralensis; Proteobacteria; arid lands; bacterial communities; biofertilizers; community structure; endophytes; fungal communities; fungi; licorice; microbiome; nitrogen; phosphorus; plant growth; potassium; rhizosphere; sequence homology; soil microorganisms; soil nutrients; soil organic matter; water stress
Abstract:
... Dark septate endophytes (DSE) are facultative biotrophic ascomycetes that colonize plant roots. DSE may provide nutrients to their plant hosts and help them adapt to various abiotic and biotic stresses. However, their effects on the microbiome composition in plant rhizosphere need further clarification. Here, we conducted a pot experiment to establish whether the responses of licorice (Glycyrrhiza ...
DOI:
10.1016/j.apsoil.2021.103993

88. Comprehensive evaluation of Licorice extract by five-dimensional quantitative profiling

Author:
Lili Lan; Wanyang Sun; Qian Chang; Guoxiang Sun
Source:
Journal of chromatography 2021 v.1644 pp. 462105
ISSN:
0021-9673
Subject:
cluster analysis; licorice; medicine
Abstract:
... Licorice extract (LE) is widely used in food and medicine fields. The detection of single chemical component cannot describe its overall quality. In this paper, the content of five active components and HPLC fingerprint of LE was determined. Firstly, the dual-standard system calibration method was proposed to correct the differences between different chromatographic systems. Then, the five-dimensi ...
DOI:
10.1016/j.chroma.2021.462105

89. Comprehensive structure-activity-relationship studies of sensory active compounds in licorice (Glycyrrhiza glabra)

Author:
Christian Schmid; Anne Brockhoff; Yaron Ben Shoshan-Galeczki; Maximilian Kranz; Timo D. Stark; Rukiye Erkaya; Wolfgang Meyerhof; Masha Y. Niv; Corinna Dawid; Thomas Hofmann
Source:
Food chemistry 2021 v.364 pp. 130420
ISSN:
0308-8146
Subject:
Glycyrrhiza glabra; food chemistry; licorice; phytochemicals; saponins; taste; triterpenoids
Abstract:
... Licorice saponins, the main constituents of Glycyrrhiza glabra L. roots, are highly appreciated by the consumer for their pleasant sweet and long lasting licorice taste. The objective of the present study was to understand the molecular features that contribute to bitter, sweet and licorice sensation of licorice roots, and whether individual compounds elicit more than one of these sensations. Ther ...
DOI:
10.1016/j.foodchem.2021.130420

90. Data on dose-dependent cytotoxicity of rotenone and neuroprotection conferred by Yashtimadhu (Glycyrrhiza glabra L.) in an in vitro Parkinson's disease model

Author:
Gayathree Karthikkeyan; Ashwini Prabhu; Ravishankar Pervaje; Sameera Krishna Pervaje; Prashant Kumar Modi; Thottethodi Subrahmanya Keshava Prasad
Source:
Data in Brief 2021 v.39 pp. 107535
ISSN:
2352-3409
Subject:
Glycyrrhiza glabra; Parkinson disease; alternative medicine; apoptosis; cell cycle; cytotoxicity; disease models; dose response; licorice; neuroprotective effect; oxidative stress; protein-protein interactions; rotenone; toxicity testing
Abstract:
... The data described in this article presents the toxicity of rotenone and the neuroprotective effect of Yashtimadhu choorna (powder) in an in vitro Parkinson's disease model [1]. Yashtimadhu choorna is prepared from the roots of Glycyrrhiza glabra L., commonly known as licorice/ liquorice. The effects of rotenone and Yashtimadhu was assessed using cellular and molecular assays such as cell cytotoxi ...
DOI:
10.1016/j.dib.2021.107535

91. Dietary effect of licorice (Glycyrrhiza glabra) on quail performance, carcass, blood metabolites and intestinal microbiota

Author:
F.M. Reda; M.T. El-Saadony; T.K. El-Rayes; M. Farahat; G. Attia; M. Alagawany
Source:
Poultry science 2021 v.100 no.8 pp. 101266
ISSN:
0032-5791
Subject:
Coturnix japonica; Escherichia coli; Glycyrrhiza glabra; Salmonella; antioxidant activity; blood; body weight; cholesterol; diet; feed conversion; feed intake; gizzard; growth performance; heart; immunity; immunoglobulin G; intestinal microorganisms; kidneys; lactate dehydrogenase; licorice; lipid composition; liver; low density lipoprotein; metabolites; protein content; quails; superoxide dismutase; triacylglycerols
Abstract:
... This study aimed to assess the impacts of licorice (Glycyrrhiza glabra) on the growth performance, carcass traits, intestinal microbiota, liver and kidney functions, immunity, oxidative status, and lipid profile of Japanese quails. A total of 200 one-week-old unsexed Japanese quails with an average initial body weight of 26.24 ± 0.2 g were randomly distributed into 5 equal groups of 40 birds and f ...
DOI:
10.1016/j.psj.2021.101266

92. Dietary licorice (Glycyrrhiza glabra) improves growth, lipid metabolism, antioxidant and immune responses, and resistance to crowding stress in common carp, Cyprinus carpio

Author:
Hossein Adineh; Mahdi Naderi; Morteza Yousefi; Mohammad Khademi Hamidi; Ehsan Ahmadifar; Seyyed Morteza Hoseini
Source:
Aquaculture nutrition 2021 v.27 no.2 pp. 417-426
ISSN:
1353-5773
Subject:
Cyprinus carpio; Glycyrrhiza glabra; antioxidants; aquaculture; blood serum; carboxylic ester hydrolases; catalase; cholesterol; complement; cortisol; fish; glutathione peroxidase; immune response; immunoglobulins; licorice; lipid metabolism; lysozyme; malondialdehyde; stress tolerance; triacylglycerols
Abstract:
... This study aimed to investigate the effects of dietary licorice (Glycyrrhiza glabra) on growth, lipid metabolism, antioxidant and immune response, and stress resistance of common carp. The fish (12.14 ± 0.39 g) were fed diets containing 0 (control), 10 (G1), 20 (G2) and 30 (G3) g/kg licorice root powder for 60 days and then subjected to 3‐hr crowding stress (40 kg/m³). The highest final weight and ...
DOI:
10.1111/anu.13194

93. Discovery of hCES2A inhibitors from Glycyrrhiza inflata via combination of docking-based virtual screening and fluorescence-based inhibition assays

Author:
Yun-Qing Song; Xiao-Qing Guan; Zi-Miao Weng; Jun-Ling Liu; Jing Chen; Lu Wang; Long-Tao Cui; Sheng-Quan Fang; Jie Hou; Guang-Bo Ge
Source:
Food & function 2021 v.12 no.1 pp. 162-176
ISSN:
2042-650X
Subject:
Glycyrrhiza inflata; antineoplastic agents; carboxylesterase; chalcones; diarrhea; drug toxicity; flavonols; fluorescein diacetate hydrolysis; herbal medicines; human cell lines; humans; ingredients; intestines; kinetics; licorice; naringenin; patients; screening; traditional medicine
Abstract:
... Human carboxylesterase 2 (hCES2A) is a key target to ameliorate the intestinal toxicity triggered by irinotecan that causes severe diarrhea in 50%–80% of patients receiving this anticancer agent. Herbal medicines are frequently used for the prevention and treatment of the intestinal toxicity of irinotecan, but it is very hard to find strong hCES2A inhibitors from herbal medicines in an efficient w ...
DOI:
10.1039/d0fo02140g

94. Does Complex Soil Enhance Grain Yield under Cropping System?

Author:
Jiakun Yan; Puling Liu
Source:
Agronomy 2021 v.11 no.8 pp. -
ISSN:
2073-4395
Subject:
Setaria italica; agronomy; biochar; biomass; catalase; climate change; crop rotation; formic acid; glycyrrhizin; grain yield; licorice; organic matter; oxalic acid; phosphorus; soil amendments; soil pH; soil quality; soil treatment; tartaric acid
Abstract:
... Global climate change and the increasing population have increased the difficulties associated with grain production. Several measures have been established to maintain a high crop yield, while preserving or increasing soil health, including biochar application to soil, and producing new complex soil with soil amendment application, e.g., biochar and soft rocks. However, previous studies have focu ...
DOI:
10.3390/agronomy11081502

95. Does the treatment of dried herbs with ozone as a fungal decontaminating agent affect the active constituents?

Author:
Salama A. Ouf; Enas M. Ali
Source:
Environmental pollution 2021 v.277 pp. 116715
ISSN:
0269-7491
Subject:
Fusarium; Mentha piperita nothosubsp. piperita; Nigella sativa; Penicillium; Rhizopus; aflatoxins; chamomile; decontamination; essential oils; fennel; food preservation; fumigation; fungal contamination; fungi; industrial applications; inoculum; licorice; microbial load; ozonation; ozone; plate count; pollution; sanitation; solar drying; spores; traditional foods
Abstract:
... Herbs and spices are food crops susceptible to contamination by toxigenic fungi. Ozone, as a decontamination approach in the industry, has attractive benefits over traditional food preservation practices. A contribution to the studying of ozone as an antifungal and anti-mycotoxigenic agent in herbs and spices storage processes is achieved in this research. Nine powdered sun-dried herbs and spices ...
DOI:
10.1016/j.envpol.2021.116715

96. Drying of licorice root by novel radiative methods

Author:
Filiz Icier; Duygu Ozmen; Mutlu Cevik; Omer Faruk Cokgezme
Source:
Journal of food processing and preservation 2021 v.45 no.3 pp. e15214
ISSN:
0145-8892
Subject:
carbon; carbon fibers; color; energy efficiency; exergy; heat transfer coefficient; infrared dryers; licorice; temperature
Abstract:
... In this study, licorice root was successfully dried using two different radiative dryers (Carbon fiber‐assisted cabin drying‐CFACD and infrared drying‐ID), and their effects on some drying characteristics, quality properties, and energy‐exergy efficiency were investigated. Page and Verma models were the best models describing the drying behavior of licorice root for CFACD and ID methods, respectiv ...
DOI:
10.1111/jfpp.15214

97. Effect of licorice on patients with HSD11B1 gene polymorphisms- a pilot study

Author:
Nayana Devang; Prabha Adhikari; M. Nandini; Kapaettu Satyamoorthy; Padmalatha S. Rai
Source:
Journal of Ayurveda and integrative medicine 2021 v.12 no.1 pp. 131-135
ISSN:
0975-9476
Subject:
Ayurvedic medicine; Glycyrrhiza glabra; blood serum; genes; genetic polymorphism; insulin; licorice; noninsulin-dependent diabetes mellitus; oxidoreductases; placebos
Abstract:
... The positive association of HSD11B1 gene polymorphism with type 2 diabetes (T2D) and prediabetic conditions has been revealed. In the current study, we assessed the effectiveness of licorice on the clinical profile of the patients with HSD11B1 gene polymorphism. Licorice (Glycyrrhiza Glabra) is a competitive inhibitor of 11 beta-hydroxysteroid dehydrogenase 1 (11β-HSD1) enzyme and has been traditi ...
DOI:
10.1016/j.jaim.2020.06.006

98. Effects of glycyrrhizin on the growth cycle and ATPase activity of PRRSV-2-infected MARC-145 cells

Author:
Erzhen Duan; Beibei Zhang; Xiaoqing Liang; Huiyuan Jing; Cen Liu; Fenghua Zhang; Jin Huang; Lanli Su; Jinrong Wang
Source:
Research in veterinary science 2021 v.138 pp. 30-38
ISSN:
0034-5288
Subject:
Betaarterivirus suid 2; Cercopithecus aethiops; adenosinetriphosphatase; cell growth; cell lines; glycyrrhizin; kidneys; licorice; porcine reproductive and respiratory syndrome; pork industry; research; veterinary medicine; viruses
Abstract:
... Porcine reproductive and respiratory syndrome (PRRS) is a viral infectious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV) and is devastating the swine industry. MARC-145 cells, an African green monkey kidney cell line, are sensitive to PRRSV-2, and are often used for in vitro studies on PRRSV-2. Preliminary research has shown that glycyrrhizin, an important activ ...
DOI:
10.1016/j.rvsc.2021.05.011

99. Efficacy of an optimized extract from licorice roots (Glycyrrhiza uralensis fischer) against viral hemorrhagic septicemia virus in olive flounder (Paralichthys olivaceus)

Author:
Jae‐Woong Lim; Joong‐Kyeong Seo; Sung‐Ju Jung; So Young Kang
Source:
Aquaculture research 2021 v.52 no.6 pp. 2609-2621
ISSN:
1355-557X
Subject:
Glycyrrhiza uralensis; Paralichthys olivaceus; Viral hemorrhagic septicemia virus; antiviral properties; aquaculture; body weight; ethanol; glycyrrhetinic acid; glycyrrhizin; licorice; median effective concentration; research; septicemia; temperature; therapeutics; viruses; Korean Peninsula
Abstract:
... Viral hemorrhagic septicemia causes significant economic losses for olive flounder (Paralichthys olivaceus) farms in Korea. The purpose of this study was to optimize extraction conditions for licorice (Glycyrrhiza uralensis roots) extract using the 2³ full factorial design and thereby optimizing the antiviral activity against viral hemorrhagic septicemia virus (VHSV). The optimum conditions were e ...
DOI:
10.1111/are.15108

100. Enhancement of nutraceutical properties of licorice callus cultures using sample pre‐treatment strategy

Author:
Supaluk Krittanai; Hathairat Buraphaka; Seiichi Sakamoto; Waraporn Putalun
Source:
International journal of food science & technology 2021 v.56 no.11 pp. 5843-5852
ISSN:
0950-5423
Subject:
Glycyrrhiza glabra; Glycyrrhiza inflata; anti-inflammatory activity; biotransformation; callus; dietary supplements; food science; formononetin; functional foods; gene expression; health promotion; inducible nitric oxide synthase; interleukin-6; licorice; metabolites; sweets; technology
Abstract:
... Licorice is an herbal plant in the Leguminosae family, and its roots and rhizomes are used as sweeteners in food and confectionery products. Moreover, it has a distinct inflammatory activity. In the present study, a sample pre‐treatment method to induce the deglycosylation of active metabolites in callus cultures of Glycyrrhiza inflata (GI) and Glycyrrhiza glabra (GG) was developed. The results of ...
DOI:
10.1111/ijfs.15156