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- Raychowdhury, Raktima, et al. Show all 18 Authors
- Cell 2015 v.162 pp. 675-686
- dendritic cells; genes; lipopolysaccharides; mammals; messenger RNA; pathogens; tumor necrosis factors
- ... Finding the components of cellular circuits and determining their functions systematically remains a major challenge in mammalian cells. Here, we introduced genome-wide pooled CRISPR-Cas9 libraries into dendritic cells (DCs) to identify genes that control the induction of tumor necrosis factor (Tnf) by bacterial lipopolysaccharide (LPS), a key process in the host response to pathogens, mediated by ...
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