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You searched for: Subject term liquid chromatography Remove constraint Subject term: liquid chromatography Subject term hydroxylation Remove constraint Subject term: hydroxylation
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1. Bioprocess performance, transformation pathway, and bacterial community dynamics in an immobilized cell bioreactor treating fludioxonil-contaminated wastewater under microaerophilic conditions

Author:
Ζografina Mavriou; Ioanna Alexandropoulou; Paraschos Melidis; Dimitrios G. Karpouzas; Spyridon Ntougias
Source:
Environmental science and pollution research 2022 v.29 no.20 pp. 29597-29612
ISSN:
0944-1344
Subject:
Clostridium; Oligotropha; Pseudomonas; activated sludge; aeration; bacterial communities; bioprocessing; bioreactors; community structure; deamination; denitrification; depuration; fludioxonil; fruits; hydroxylation; immobilized cells; liquid chromatography; mass spectrometry; moieties; oxidation; pollution; pyrroles; research; wastewater
Abstract:
... Fludioxonil is a post-harvest fungicide contained in effluents produced by fruit packaging plants, which should be treated prior to environmental dispersal. We developed and evaluated an immobilized cell bioreactor, operating under microaerophilic conditions and gradually reduced hydraulic retention times (HRTs) from 10 to 3.9 days, for the biotreatment of fludioxonil-rich wastewater. Fludioxonil ...
DOI:
10.1007/s11356-021-16452-3

2. Development and validation of a liquid chromatography-tandem mass spectrometry method for comprehensive detection of organophosphate esters and their degradation products in sediment

Author:
Li Zhang; Liqiong Meng; Hua Wang; Dongliang Lu; Xin Luo
Source:
Journal of chromatography 2022 v.1665 pp. 462826
ISSN:
0021-9673
Subject:
chemical species; esters; hydroxylation; liquid chromatography; marine environment; marine sediments; organophosphorus compounds; phosphates; solid phase extraction; tandem mass spectrometry; toxicity
Abstract:
... The present work aimed at the development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for comprehensive determination of twelve organophosphate (OP) triesters, five OP diesters and two hydroxylated degradation products in sediment. As the target compound possess a wide range of physicochemical properties, different LC-MS/MS conditions and sample preparation strategies wer ...
DOI:
10.1016/j.chroma.2022.462826

3. Enzymatic synthesis and formation kinetics of mono- and di-hydroxylated chlorinated paraffins with the bacterial dehalogenase LinB from Sphingobium indicum

Author:
Marco C. Knobloch; Flurin Mathis; Thomas Fleischmann; Hans-Peter E. Kohler; Susanne Kern; Davide Bleiner; Norbert V. Heeb
Source:
Chemosphere 2022 v.291 pp. 132939
ISSN:
0045-6535
Subject:
Sphingomonas; chlorination; environmental fate; hydroxylation; lipophilicity; liquid chromatography; mass spectrometry; toxicity
Abstract:
... Transformation studies of chlorinated paraffins (CPs) and the effects of CP transformation products on humans, biota and environment are rare. The focus here is on hydroxylation reactions. As for polyhalogenated persistent organic pollutants (POPs) in general, hydroxylation reactions convert lipophilic material to more polar compounds with increased mobility. We investigated the in-vitro transform ...
DOI:
10.1016/j.chemosphere.2021.132939

4. Liquid-liquid extraction combined with online cleanup for the simultaneous determination of PAHs by GC–MS/MS and their hydroxylated metabolites by LC-MS/MS in human fingernails

Author:
Zihuan Zeng; Yuan Gao; Juntao Cui; Meiqing Lin; Jian Tang; Fei Wang; Yan Yang; Yingxin Yu; Shengtao Ma
Source:
Journal of chromatography 2022 v.1188 pp. 123057
ISSN:
1570-0232
Subject:
acetone; decontamination; environmental monitoring; ethyl acetate; fluorenes; gels; hexane; humans; hydroxylation; liquid chromatography; liquid-liquid extraction; metabolites; methylene chloride; naphthalene; permeability; phenanthrenes; sodium hydroxide; solid phase extraction; tandem mass spectrometry; China
Abstract:
... A method was developed for the simultaneous determination of polycyclic aromatic hydrocarbons (PAHs) and their hydroxylated metabolites (OH-PAHs) in human fingernails using liquid–liquid extraction and online purification. After surface decontamination by rinsing with acetone, the fingernails were digested with sodium hydroxide and subjected to liquid–liquid extraction with a mixture of n-hexane a ...
DOI:
10.1016/j.jchromb.2021.123057

5. Actinomycetes Rhodococcus ruber CGMCC 17550 degrades neonicotinoid insecticide nitenpyram via a novel hydroxylation pathway and remediates nitenpyram in surface water

Author:
Zhi-Ling Dai; Wen-Long Yang; Zhi-Xia Fan; Ling Guo; Zhong-Hua Liu; Yi-Jun Dai
Source:
Chemosphere 2021 v.270 pp. 128670
ISSN:
0045-6535
Subject:
Rhodococcus ruber; bacteria; biodegradation; biomass; bioremediation; cytochrome P-450; dissolved oxygen; ecosystems; fructose; glucose; hydroxylation; liquid chromatography; mass spectrometry; metabolism; metabolites; neurotoxins; nitenpyram; nuclear magnetic resonance spectroscopy; pollution; pyruvic acid; sewage treatment; surface water; xenobiotics
Abstract:
... Neonicotinoid insecticides are neurotoxicants that cause serious environmental pollution and ecosystem risks. In the present study, a nitenpyram-degrading bacterium, Rhodococcus ruber CGMCC 17550, was isolated from a nitenpyram production sewage treatment tank. Liquid chromatography-mass spectrometry analysis revealed R. ruber degraded nitenpyram via a novel hydroxylation pathway to form three dif ...
DOI:
10.1016/j.chemosphere.2020.128670

6. Analytical approaches for studying oxygenated lipids in the search of potential biomarkers by LC-MS

Author:
Alma Villaseñor; Joanna Godzien; Tomás Clive Barker-Tejeda; Carolina Gonzalez-Riano; Ángeles López-López; Danuta Dudzik; Ana Gradillas; Coral Barbas
Source:
Trends in analytical chemistry 2021 v.143 pp. 116367
ISSN:
0165-9936
Subject:
analytical chemistry; biomarkers; cardiolipins; cholesterol; derivatization; diabetes; glycerophospholipids; hydroxylation; lipid peroxidation; lipidomics; liquid chromatography; mass spectrometry; oxidation; sphingolipids
Abstract:
... Great advances in lipidomics during the last years have opened the door to a broader knowledge of oxygenated lipids. These substances are derived either from the inclusion of previously hydroxylated fatty acids in the lipid structure of sphingolipids and acyl-L-carnitines, or by enzymatic and non-enzymatic modifications (oxidized lipids) of glycerophospholipids (including cardiolipins), cholestery ...
DOI:
10.1016/j.trac.2021.116367

7. Application of liquid chromatography coupled to data-independent acquisition mass spectrometry for the metabolic profiling of N-ethyl heptedrone

Author:
Monica Mazzarino; Cristian Camuto; Fabio Comunità; Xavier de la Torre; Carlotta Stacchini; Francesco Botrè
Source:
Journal of chromatography 2021 v.1185 pp. 122989
ISSN:
1570-0232
Subject:
biotransformation; chemical species; cytochrome P-450; drugs; enzymatic hydrolysis; humans; hydroxylation; liquid chromatography; liquid-liquid extraction; liver microsomes; mass spectrometry; metabolism; metabolites; pH; uridine
Abstract:
... We have investigated the metabolic profile of N-ethyl heptedrone, a new designer synthetic stimulant drug, by using data independent acquisition mass spectrometry. Phase I and phase II metabolism was studied by in vitro models, followed by liquid-chromatography coupled to mass spectrometry, to characterize and pre-select the most diagnostic markers of intake. N-ethyl heptedrone was incubated in th ...
DOI:
10.1016/j.jchromb.2021.122989

8. Assessing the bioremediation potential of indigenously isolated Klebsiella sp. WAH1 for diclofenac sodium: optimization, toxicity and metabolic pathway studies

Author:
Saloni Sharma; Hema Setia; Amrit Pal Toor
Source:
World journal of microbiology & biotechnology 2021 v.37 no.2 pp. 33
ISSN:
0959-3993
Subject:
Klebsiella pneumoniae; absorbance; activated sludge; anti-inflammatory agents; aquatic environment; biochemical pathways; bioremediation; biotechnology; carbon; chemical structure; decarboxylation; dechlorination; diclofenac; energy; hydroxylation; industrial wastewater; inoculum; liquid chromatography; pH; temperature; toxicity
Abstract:
... Among the various pharmaceutical pollutants, diclofenac sodium (DFS), a widely prescribed non-steroid anti-inflammatory drug is detected in the aquatic environment at concentrations which can be harmful to living organisms. Present study illustrates the isolation and characterization of strain Klebsiella pneumoniae WAH1 from activated sludge and its ability to degrade DFS as sole source of carbon ...
DOI:
10.1007/s11274-021-02998-4

9. Determination and occurrence of sulfonamide transformation products in surface waters

Author:
Hongyang Cui; Hong Chang; Hongjin Zheng; Yi Wan
Source:
Science of the total environment 2021 v.779 pp. 146562
ISSN:
0048-9697
Subject:
acetylation; aquatic environment; hydroxylation; liquid chromatography; metabolism; pollution; sulfadiazine; sulfamethoxazole; sulfapyridine; tandem mass spectrometry; China
Abstract:
... The transformation products of sulfonamides (SAs) have raised increasing environmental and health concerns in recent years, but information on their analysis and environmental fates remains limited. In this study, an analytical method using liquid chromatography with tandem mass spectrometry (LC-MSMS) was optimized to simultaneously analyze 9 SA transformation products and 14 SAs in water samples. ...
DOI:
10.1016/j.scitotenv.2021.146562

10. Electrochemistry-coupled to liquid chromatography-mass spectrometry-density functional theory as a new tool to mimic the environmental degradation of selected phenylurea herbicides

Author:
Ranil Clément Tonleu Temgoua; Ugo Bussy; Dimitri Alvarez-Dorta; Nicolas Galland; Evangeline Njanja; Julie Hémez; Christine Thobie-Gautier; Ignas Kenfack Tonlé; Mohammed Boujtita
Source:
Environmental science 2021 v.23 no.10 pp. 1600-1611
ISSN:
2050-7895
Subject:
carbon; chlorotoluron; electrochemistry; electrospray ionization mass spectrometry; environmental degradation; fenuron; glutathione; hydroxylation; imines; isoproturon; linuron; liquid chromatography; metoxuron; monolinuron; monuron; oxidation; quinones
Abstract:
... In vitro and in vivo experimental models, mainly based on cell cultures, animals, healthy humans and clinical trials, are useful approaches for identifying the main metabolic pathways. However, time, cost, and matrix complexity often hinder the success of these methods. In this study, we propose an alternative non-enzymatic method, using electrochemistry (EC) coupled to liquid chromatography (LC) ...
DOI:
10.1039/d1em00351h

11. Elucidation of the photoinduced transformations of Aliskiren in river water using liquid chromatography high-resolution mass spectrometry

Author:
Nuno P.F. Gonçalves; Lucia Iezzi; Masho H. Belay; Valeria Dulio; Nikiforos Alygizakis; Federica Dal Bello; Claudio Medana; Paola Calza
Source:
Science of the total environment 2021 v.800 pp. 149547
ISSN:
0048-9697
Subject:
computer simulation; drugs; environment; freshwater; half life; hydroxylation; lighting; liquid chromatography; mass spectrometry; oxidation; photolysis; pollutants; risk; river water; rivers; seawater; toxicity
Abstract:
... Aliskiren was selected as a compound of potential concern among a suspect screening list of more than 40,000 substances on a basis of high occurrence, potential risk and the absence of information about its environmental fate.This study investigated the photoinduced degradation of aliskiren in river water samples spiked at trace levels exposed to simulated sunlight. A half-life time of 24 h was ob ...
DOI:
10.1016/j.scitotenv.2021.149547

12. Identification of novel halogenated naturally occurring compounds in marine biota by high-resolution mass spectrometry and combined screening approaches

Author:
Lidia Belova; Yukiko Fujii; Paulien Cleys; Monika Śmiełowska; Koichi Haraguchi; Adrian Covaci
Source:
Environmental pollution 2021 v.289 pp. 117933
ISSN:
0269-7491
Subject:
algae; biphenyl; gas chromatography; hydroxylation; liquid chromatography; mass spectrometry; pollution
Abstract:
... Marine animals, plants or bacteria are a source of bioactive naturally-occurring halogenated compounds (NHCs) such as bromophenols (BPs), bromoanisoles (BAs) and hydroxylated or methoxylated analogues of polybrominated diphenyl ethers (HO-PBDEs, MeO-PBDEs) and bromobiphenyls (HO-BBs, MeO-BBs). This study applied a comprehensive screening approach using liquid chromatography high-resolution mass sp ...
DOI:
10.1016/j.envpol.2021.117933

13. Investigation of novel brominated triazine-based flame retardant (TDBP-TAZTO) and its transformation products emitted from fire-retarded textile manufacturing facility and its downstream sewage treatment plant

Author:
Hidenori Matsukami; Shunji Hashimoto; Go Suzuki
Source:
Science of the total environment 2021 v.791 pp. 148233
ISSN:
0048-9697
Subject:
bromination; computer software; environment; fabrics; flame retardants; human health; hydroxylation; liquid chromatography; mass spectrometry; pollution; product life cycle; sewage treatment; sludge
Abstract:
... Investigation of transformation products from novel flame retardants emitted throughout their life cycles is crucial for understanding and predicting environmental and human health risks posed by them during the material and product life cycle. Here, to understand more about the emission of TDBP-TAZTO to the environment, we investigated the presence of novel brominated triazine-based flame retarda ...
DOI:
10.1016/j.scitotenv.2021.148233

14. Nitrite-mediated photodegradation of sulfonamides and formation of nitrated products

Author:
Xu Gao; Junhe Lu; Yuefei Ji; Jing Chen; Xiaoming Yin; Quansuo Zhou
Source:
Chemosphere 2021 v.282 pp. 130968
ISSN:
0045-6535
Subject:
density functional theory; heterocyclic compounds; hydroxylation; irradiation; kinetics; liquid chromatography; mass spectrometry; nitrites; organic matter; photolysis; sulfamethazine; sulfamethizole; sulfamethoxazole; sulfapyridine
Abstract:
... In this study, we systematically investigated the indirect photolysis of five SAs, i.e., sulfamethazine (SMZ), sulfamethoxazole (SMX), sulfathiazole (STZ), sulfapyridine (SPD), and sulfamethizole (SMT), under UV-A irradiation (365 nm) and mediated by nitrite (NO₂‾) at environmentally relevant concentrations (0.005–0.1 mM). The SAs that are resistant to direct photolysis can be effectively removed ...
DOI:
10.1016/j.chemosphere.2021.130968

15. Organic Markers of Tire and Road Wear Particles in Sediments and Soils: Transformation Products of Major Antiozonants as Promising Candidates

Author:
Philipp Klöckner; Bettina Seiwert; Stephan Wagner; Thorsten Reemtsma
Source:
Environmental science & technology 2021 v.55 no.17 pp. 11723-11732
ISSN:
1520-5851
Subject:
detection limit; environmental science; equipment; hydroxylation; liquid chromatography; quinones; traffic
Abstract:
... Tire and road wear particles (TRWPs) are one of the main sources of particulate traffic emissions, but measured data on TRWP contents in the environment are scarce. This study aims at identifying organic compounds suitable as quantitative markers for TRWPs by a tiered multistep selection process involving nontarget screening and subsequent identification by liquid-chromatography high-resolution ma ...
DOI:
10.1021/acs.est.1c02723

16. Study of the photoinduced transformations of maprotiline in river water using liquid chromatography high-resolution mass spectrometry

Author:
Nuno P.F. Gonçalves; Zsuzsanna Varga; Stéphane Bouchonnet; Valeria Dulio; Nikiforos Alygizakis; Federica Dal Bello; Claudio Medana; Paola Calza
Source:
Science of the total environment 2021 v.755 pp. 143556
ISSN:
0048-9697
Subject:
drugs; environment; environmental fate; hydroxylation; liquid chromatography; mass spectrometry; oxidation; photocatalysis; photolysis; risk; river water; toxicity; wastewater treatment
Abstract:
... Maprotiline was identified as a compound of potential interest further to a suspect screening test carried out for a list of more than 40,000 substances based on specific occurrence, hazard and risk indicators. Despite the high frequency of appearance of this drug in wastewater treatment stations, his environmental fate is still unknown. Herein, we investigated for the first time the maprotiline d ...
DOI:
10.1016/j.scitotenv.2020.143556

17. The correlation between the level of 3-hydroxypropyl mercapturic acid, CYP2B6 polymorphisms, and hematuria occurrences after cyclophosphamide administration and its bioanalytical methods: A systematic review

Author:
Yahdiana Harahap; Farhan Nurahman; Denni Joko Purwanto; Arry Yanuar
Source:
Heliyon 2021 v.7 no.10 pp. e08126
ISSN:
2405-8440
Subject:
Internet; acetonitrile; acetylcysteine; acidification; acrolein; cyclophosphamide; cytochrome P-450; cytotoxicity; databases; drug therapy; electrospray ionization mass spectrometry; enzymes; ethics; formic acid; hematuria; humans; hydroxylation; liquid chromatography; metabolites; pharmacodynamics; pharmacokinetics; polymerase chain reaction; risk; systematic review; tandem mass spectrometry; urine; Indonesia
Abstract:
... Cyclophosphamide (CPA) is a cytotoxic prodrug that needs to be metabolized by cytochrome P450 enzymes, like CYP2B6. Unfortunately, CYP2B6 is a very polymorphic enzyme and can cause a change in 3-hydroxypropyl mercapturic acid (3-HPMA), the most found CYP metabolite in urine levels. Change in 3-HPMA levels can also indicate the level change in its precursor, acrolein, which is responsible for the h ...
DOI:
10.1016/j.heliyon.2021.e08126

18. Transformation of short-chain chlorinated paraffins by the bacterial haloalkane dehalogenase LinB – Formation of mono- and di-hydroxylated metabolites

Author:
Marco C. Knobloch; Lena Schinkel; Iris Schilling; Hans-Peter E. Kohler; Peter Lienemann; Davide Bleiner; Norbert V. Heeb
Source:
Chemosphere 2021 v.262 pp. 128288
ISSN:
0045-6535
Subject:
Escherichia coli; HCH (pesticide); chlorides; chlorination; heterologous gene expression; hexabromocyclododecane; hydroxylation; ionization; liquid chromatography; mass spectrometry; metabolites; toxicity; toxicology
Abstract:
... Short-chain chlorinated paraffins (SCCPs) are listed as persistent organic pollutants (POPs) under the Stockholm Convention. Such substances are toxic, bioaccumulating, transported over long distances and degrade slowly in the environment. Certain bacterial strains of the Sphingomonadacea family are able to degrade POPs, such as hexachlorocyclohexanes (HCHs) and hexabromocyclododecanes (HBCDs). Th ...
DOI:
10.1016/j.chemosphere.2020.128288

19. Ultra-high pressure liquid chromatography coupled to travelling wave ion mobility-time of flight mass spectrometry for the screening of pharmaceutical metabolites in wastewater samples: Application to antiretrovirals

Author:
Tlou T. Mosekiemang; Maria A. Stander; André de Villiers
Source:
Journal of chromatography 2021 v.1660 pp. 462650
ISSN:
0021-9673
Subject:
abacavir; aquatic environment; chemical species; environmental health; hydroxylation; liquid chromatography; mass spectrometry; metabolites; pharmacokinetics; sewage treatment; wastewater; wastewater treatment; South Africa
Abstract:
... The presence of pharmaceutical compounds in the aquatic environment is a significant environmental health concern, which is exacerbated by recent evidence of the contribution of drug metabolites to the overall pharmaceutical load. In light of a recent report of the occurrence of metabolites of antiretroviral drugs (ARVDs) in wastewater, we investigate in the present work the occurrence of further ...
DOI:
10.1016/j.chroma.2021.462650

20. Activation of peroxymonosulfate by Fe doped g-C3N4 /graphene under visible light irradiation for Trimethoprim degradation

Author:
Ruobai Li; Jiashu Huang; Meixuan Cai; Jiaxing Huang; Zhijie Xie; Qianxin Zhang; Yang Liu; Haijin Liu; Wenying Lv; Guoguang Liu
Source:
Journal of hazardous materials 2020 v.384 pp. 121435
ISSN:
0304-3894
Subject:
acute toxicity; carbon nitride; catalysts; electron paramagnetic resonance spectroscopy; free radicals; graphene oxide; hydroxylation; iron; irradiation; liquid chromatography; oxidation; pH; polymers; remediation; superoxide anion; tandem mass spectrometry; toxic substances; trimethoprim
Abstract:
... Fe-doped g-C₃N₄ / graphene (rGO) composites were investigated as catalysts for the activation of peroxymonosulfate (PMS) to degrade Trimethoprim (TMP) under visible light irradiation. The rapid recombination of photogenerated electron-hole pairs in g-C₃N₄ may be suppressed by doping with Fe and incorporating rGO. The TMP degradation efficiency using 0.2% Fe-g-C₃N₄/2 wt% rGO/PMS was 3.8 times than ...
DOI:
10.1016/j.jhazmat.2019.121435

21. Biodegradation and toxicity reduction of nonylphenol, 4-tert-octylphenol and 2,4-dichlorophenol by the ascomycetous fungus Thielavia sp HJ22: Identification of fungal metabolites and proposal of a putative pathway

Author:
Rim Mtibaà; Abdellah Ezzanad; Elisabet Aranda; Clementina Pozo; Bouthaina Ghariani; Javier Moraga; Moncef Nasri; Jesús Manuel Cantoral; Carlos Garrido; Tahar Mechichi
Source:
Science of the total environment 2020 v.708 pp. 135129
ISSN:
0048-9697
Subject:
2,4-dichlorophenol; Thielavia; Vibrio fischeri; biochemical pathways; biodegradation; biosorption; cytochrome P-450; enzyme inhibition; fungi; humans; hydroxylation; laccase; liquid chromatography; mass spectrometry; metabolites; nonylphenols; oxidation; pollutants; toxicity; xenobiotics
Abstract:
... Research on the biodegradation of emerging pollutants is gained great focus regarding their detrimental effects on the environment and humans. The objective of the present study was to evaluate the ability of the ascomycetes Thielavia sp HJ22 to remove the phenolic xenobiotics nonylphenol (NP), 4-tert-octylphenol (4-tert-OP) and 2,4-dichlorophenol (2,4-DCP). The strain showed efficient degradation ...
DOI:
10.1016/j.scitotenv.2019.135129

22. Biodegradation of fluoroquinolone antibiotics and the climbazole fungicide by Trichoderma species

Author:
Rayana Manasfi; Serge Chiron; Nicola Montemurro; Sandra Perez; Monica Brienza
Source:
Environmental science and pollution research international 2020 v.27 no.18 pp. 23331-23341
ISSN:
0944-1344
Subject:
activated sludge; alcohols; biodegradation; biosorption; biotransformation; ciprofloxacin; cytochrome P-450; fungicides; hydroxylation; liquid chromatography; ofloxacin; oxidation; pollution; research; spectroscopy
Abstract:
... Filamentous fungi Trichoderma have been able to efficiently degrade fluoroquinolone antibiotics namely ciprofloxacin (CIP) and ofloxacin (OFL) as well as the fungicide climbazole (CLB) that are persistent in conventional activated sludge processes. All targeted compounds were biotransformed by whole cells of Trichoderma spp., exactly T. harzanium and T. asperellum, and biosorption played a limited ...
DOI:
10.1007/s11356-020-08442-8

23. Biodegradation of the endocrine disrupter 4-t-octylphenol by the non-ligninolytic fungus Fusarium falciforme RRK20: Process optimization, estrogenicity assessment, metabolite identification and proposed pathways

Author:
Ranjith Kumar Rajendran; Yi-Wen Lee; Pei-Hsin Chou; Shir-Ly Huang; Roland Kirschner; Chu-Ching Lin
Source:
Chemosphere 2020 v.240 pp. 124876
ISSN:
0045-6535
Subject:
Fusarium; adverse effects; aromatic compounds; bacteria; biodegradation; biomass; carbon; ecosystems; endocrine-disrupting chemicals; energy; environmental fate; estrogenic properties; glucose; hydroxylation; inoculum density; laboratory experimentation; liquid chromatography; mass spectrometry; metabolites; oxidation; pH; public health; remediation; response surface methodology; screening; temperature; yeasts
Abstract:
... 4-t-octylphenol (4-t-OP), a well-known endocrine disrupting compound, is frequently found in various environmental compartments at levels that may cause adverse effects to the ecosystem and public health. To date, most of the studies that investigate microbial transformations of 4-t-OP have focused on the process mediated by bacteria, ligninolytic fungi, or microbial consortia. There is no report ...
DOI:
10.1016/j.chemosphere.2019.124876

24. CYP450-Mediated metabolism of suvorexant and investigation of metabolites in forensic case specimens

Author:
Britni Skillman; Sarah Kerrigan
Source:
Forensic science international 2020 v.312 pp. 110307
ISSN:
0379-0738
Subject:
antagonists; blood plasma; cytochrome P-450; forensic sciences; hydroxylation; isozymes; liquid chromatography; mass spectrometry; mechanism of action; metabolism; metabolites; moieties; sedatives; sleep disorders; toxicology; triazoles
Abstract:
... Suvorexant (Belsomra®) is a sedative hypnotic that was approved for use in 2015. It has a novel mechanism of action and was the first dual orexin receptor antagonist (DORA) to be approved for the treatment of sleep disorders. Sedative hypnotics often feature prominently in forensic investigations such as impaired driving and drug-facilitated sexual assault (DFSA) cases. As such, suvorexant is a dr ...
DOI:
10.1016/j.forsciint.2020.110307

25. Characterizing biotransformation products and pathways of the flame retardant triphenyl phosphate in Daphnia magna using non-target screening

Author:
Yeowool Choi; Junho Jeon; Younghun Choi; Sang Don Kim
Source:
Science of the total environment 2020 v.708 pp. 135106
ISSN:
0048-9697
Subject:
Daphnia magna; aquatic environment; aquatic invertebrates; biotransformation; cysteine; depuration; flame retardants; hydroxylation; liquid chromatography; mass spectrometry; organophosphorus compounds; phosphates; screening; thiols; toxicity; toxicity testing
Abstract:
... Triphenyl phosphate (TPHP), one of the organophosphate flame retardants, has been widely used in manufacturing, thereby causing a gradual increase in TPHP concentrations in aquatic environments. However, the information on the biotransformation mechanism of TPHP in invertebrates is lacking. The study identified the biotransformation products of TPHP in Daphnia magna, which showed particularly high ...
DOI:
10.1016/j.scitotenv.2019.135106

26. Comparative spatial lipidomics analysis reveals cellular lipid remodelling in different developmental zones of barley roots in response to salinity

Author:
Lenin D. Sarabia; Berin A. Boughton; Thusitha Rupasinghe; Damien L. Callahan; Camilla B. Hill; Ute Roessner
Source:
Plant, cell and environment 2020 v.43 no.2 pp. 327-343
ISSN:
0140-7791
Subject:
Hordeum vulgare; atomic absorption spectrometry; barley; ceramides; cultivars; desorption; elemental composition; hydroxylation; image analysis; ions; lipid composition; liquid chromatography; matrix-assisted laser desorption-ionization mass spectrometry; messenger RNA; phosphatidylcholines; plant tissues; polymerase chain reaction; reverse transcription; roots; salinity; salt stress; seedlings; tandem mass spectrometry; transcriptome
Abstract:
... Salinity‐induced metabolic, ionic, and transcript modifications in plants have routinely been studied using whole plant tissues, which do not provide information on spatial tissue responses. The aim of this study was to assess the changes in the lipid profiles in a spatial manner and to quantify the changes in the elemental composition in roots of seedlings of four barley cultivars before and afte ...
DOI:
10.1111/pce.13653
PubMed:
31714612
PubMed Central:
PMC7063987

27. Comparative time-based intermediates study of ozone oxidation of 4-chloro- and 4-nitrophenols followed by LCMS-TOF

Author:
Michael Ovbare Akharame; Olalekan Siyanbola Fatoki; Beatrice Olutoyin Opeolu; Daniel Ikudayisi Olorunfemi; Ogheneochuko Utieyin Oputu
Source:
Journal of environmental science and health 2020 v.55 no.4 pp. 385-401
ISSN:
1532-4117
Subject:
4-chlorophenol; catechol; glass; hydroquinone; hydroxylation; instrumentation; liquid chromatography; oxidation; oxygen; ozonation; ozone; p-nitrophenol; quinones; spectrometers
Abstract:
... Greater insights on the degradation pathways and intermediates formed during the oxidation of organics can be achieved by more suitable and compatible instrumentation. In our research, we sought to explore the relative advantages of the liquid chromatography coupled to a time of flight mass spectrometer (LCMS-TOF) technique for the comparative time-based degradation intermediates and pathways of 4 ...
DOI:
10.1080/10934529.2019.1701340

28. Comparison of steroid hormone hydroxylation mediated by cytochrome P450 3A subfamilies

Author:
Toshiro Niwa; Ayaka Okamoto; Kanae Narita; Manami Toyota; Kyoko Kato; Kyoko Kobayashi; Shoko Sasaki
Source:
Archives of biochemistry and biophysics 2020 v.682 pp. 108283
ISSN:
0003-9861
Subject:
catalytic activity; cortisol; cytochrome P-450; humans; hydroxylation; liquid chromatography; progesterone; steroid hormones; testosterone
Abstract:
... Hydroxylation activity at the 6β-position of steroid hormones (testosterone, progesterone, and cortisol) by human cytochromes P450 (CYP) 3A4, polymorphic CYP3A5, and fetal CYP3A7 were compared to understand the catalytic properties of the major forms of human CYP3A subfamily. Testosterone, progesterone, and cortisol 6β-hydroxylation activities of recombinant CYP3A4, CYP3A5, and CYP3A7 were determi ...
DOI:
10.1016/j.abb.2020.108283

29. Degradation of the anticancer drug flutamide by solar photo-Fenton treatment at near-neutral pH: Identification of transformation products and in silico (Q)SAR risk assessment

Author:
Alexandre Della-Flora; Marcelo L. Wilde; Igor D.F. Pinto; Éder C. Lima; Carla Sirtori
Source:
Environmental research 2020 v.183 pp. 109223
ISSN:
0013-9351
Subject:
antineoplastic agents; aquatic environment; aromatic compounds; biodegradability; carcinogenicity; computer software; demethylation; environmental fate; half life; hydrogen; hydrogen peroxide; hydroxylation; iron; liquid chromatography; models; mutagenicity; nitrogen dioxide; pH; prediction; prostatic neoplasms; risk assessment; structure-activity relationships
Abstract:
... Flutamide (FLUT) is a non-steroidal drug mainly used in the treatment of prostate cancer and has been detected in the aquatic environment at ng L⁻¹ levels. The environmental fate and effects of FLUT have not yet been studied. Conventional treatment technologies fail to completely remove pharmaceuticals, so the solar photo-Fenton process (SPF) has been proposed as an alternative. In this study, the ...
DOI:
10.1016/j.envres.2020.109223

30. Detection and characterization of olmutinib reactive metabolites by LC–MS/MS: Elucidation of bioactivation pathways

Author:
Mohamed W. Attwa; Adnan A. Kadi; Ali S. Abdelhameed
Source:
Journal of separation science 2020 v.43 no.4 pp. 708-718
ISSN:
1615-9306
Subject:
adverse effects; aldehydes; bioavailability; biochemical pathways; enzyme inhibitors; epidermal growth factor receptors; glutathione; hydroxylation; ions; liquid chromatography; liver microsomes; lung neoplasms; metabolites; metastasis; patients; piperazine; potassium cyanide; quinones; rats; tandem mass spectrometry; South Korea
Abstract:
... Olmutinib (Olita™) is an orally bioavailable third generation epidermal growth factor receptor tyrosine kinase inhibitor. Olmutinib was approved in South Korea in May 2016 for the treatment of patients suffering from locally advanced or metastatic epidermal growth factor receptor T790M mutation‐positive non‐small cell lung cancer. Reactive olmutinib intermediates may be responsible for the severe ...
DOI:
10.1002/jssc.201900818

31. Development and validation of LC-ESI-MS/MS methods for quantification of 27 free and conjugated estrogen-related metabolites

Author:
Carien van der Berg; Gerda Venter; Francois H. van der Westhuizen; Elardus Erasmus
Source:
Analytical biochemistry 2020 v.590 pp. 113531
ISSN:
0003-2697
Subject:
biotransformation; breast neoplasms; carcinogenesis; derivatization; electrospray ionization mass spectrometry; estrogens; hydroxylation; liquid chromatography; metabolism; metabolites; methylation; monitoring; nutritional support; patients; risk; solid phase extraction; steroid hormones; sulfates; tandem mass spectrometry; urine; water solubility
Abstract:
... An imbalance in the estrogen metabolism has been associated with an increased risk of breast cancer development. Evaluation of the estrogen biotransformation capacity requires monitoring of various estrogen metabolites. Up to now, only some estrogen metabolites could be measured in urine. However, in order to offer tailor made nutritional support or therapies, a complete estrogen metabolite profil ...
DOI:
10.1016/j.ab.2019.113531

32. Effect of dissolved organic matters and inorganic ions on TiO2 photocatalysis of diclofenac: mechanistic study and degradation pathways

Author:
Ling Gao; Beihai Zhou; Fei Wang; Rongfang Yuan; Huilun Chen; Xiaomin Han
Source:
Environmental science and pollution research international 2020 v.27 no.2 pp. 2044-2053
ISSN:
0944-1344
Subject:
chlorides; dechlorination; diclofenac; dissolved organic matter; humic acids; hydroxyl radicals; hydroxylation; inorganic ions; iron; light; liquid chromatography; mass spectrometry; mineralization; oxidation; pH; phosphates; photocatalysis; sewage treatment; singlet oxygen; superoxide anion; titanium dioxide; total organic carbon; wastewater treatment
Abstract:
... Diclofenac (DCF) exists extensively in sewage treatment plant effluent, and it is one of the most reported environmental pharmaceutical contaminants. In this work, the photocatalytic degradation of DCF by titanium dioxide (TiO₂) in pure water under visible light and the influence of humic acids (HA) (as a kind of dissolved organic matter (DOM), phosphate and ferrous ion (Fe²⁺)) were investigated. ...
DOI:
10.1007/s11356-019-06676-9

33. Effect of nitrate on the phototreatment of Triton X-100 simulated washing waste containing 4,4′-dibromodiphenyl ether: Kinetics, products and toxicity assessment

Author:
Kaibo Huang; Jiahao Liang; Jin Wang; Yuanxi Ouyang; Rui Wang; Ting Tang; Yusen Luo; Xueqin Tao; Hua Yin; Zhi Dang; Guining Lu
Source:
Science of the total environment 2020 v.732 pp. 139247
ISSN:
0048-9697
Subject:
Escherichia coli; carboxylation; environment; hydroxylation; isomerization; liquid chromatography; mass spectrometry; nitrates; nitrites; octoxynol; organic nitrogen; pH; photolysis; photosensitivity; pollutants; reactive oxygen species; surfactants; toxicity; ultraviolet radiation; wastes
Abstract:
... This study aimed to investigate the effects of nitrate on the ultraviolet (UV) treatment of simulated washing wastes containing Trion X-100 (TX-100) surfactant and 4,4′-dibromodiphenyl ether (BDE-15) pollutant. The presence of nitrate accelerated the photodegradation of BDE-15 and TX-100, because they reacted with reactive oxygen species (ROS) produced from conversion between nitrate and nitrite. ...
DOI:
10.1016/j.scitotenv.2020.139247

34. Electrochemical microreactor combined with mass spectrometry for online oxidation and real‐time detection of alkaloids

Author:
Juan Yang; Li‐Hong Ye; Bin Wang; Hui Zheng; Jun Cao
Source:
Journal of separation science 2020 v.43 no.20 pp. 3969-3981
ISSN:
1615-9306
Subject:
berberine; carbon; dehydrogenation; demethylation; electrochemistry; electrodes; glutathione; hydroxylation; liquid chromatography; liver microsomes; mass spectrometry; methylation; oxidation; separation
Abstract:
... The main purpose of the present study was to investigate the prototypes and oxidation products of alkaloids with the use of an online electrochemistry/quadrupole time‐of‐flight mass spectrometry system. The metabolism of oxidative phase I and II was simulated in an electrochemical reaction cell. The metabolic processes for coptisine and jatrorrhizine were simulated in a thin‐layer cell fitted with ...
DOI:
10.1002/jssc.202000506

35. Extracellular matrix alterations in low‐grade lung adenocarcinoma compared with normal lung tissue by imaging mass spectrometry

Author:
Peggi M. Angel; Evelyn Bruner; Jennifer Bethard; Cassandra L. Clift; Lauren Ball; Richard R. Drake; Carol Feghali‐Bostwick
Source:
Journal of mass spectrometry 2020 v.55 no.4 pp. e4450
ISSN:
1076-5174
Subject:
adenocarcinoma; collagen; extracellular matrix; fibrosis; hydroxylation; image analysis; liquid chromatography; lungs; men; metastasis; microarray technology; patients; peptides; post-translational modification; principal component analysis; proline; proteomics; resection; tandem mass spectrometry; tissues; variance; women
Abstract:
... Lung adenocarcinoma (LUAD) is the second most common cancer, affecting both men and women. Fibrosis is a hallmark of LUAD occurring throughout progression with excess production of extracellular matrix (ECM) components that lead to metastatic cell processes. Understanding the ECM cues that drive LUAD progression has been limited due to a lack of tools that can access and report on ECM components w ...
DOI:
10.1002/jms.4450
PubMed:
31654589
PubMed Central:
PMC7145762

36. Fabrication of multi-walled carbon nanotubes and carbon black co-modified graphite felt cathode for amoxicillin removal by electrochemical advanced oxidation processes under mild pH condition

Author:
Guifang Pan; Xiuping Sun; Zhirong Sun
Source:
Environmental science and pollution research international 2020 v.27 no.8 pp. 8231-8247
ISSN:
0944-1344
Subject:
X-ray photoelectron spectroscopy; adsorption; amoxicillin; carbon nanotubes; cathodes; cleavage (chemistry); contact angle; decarboxylation; desorption; electrochemistry; graphene; hydrogen peroxide; hydroxylation; iron; liquid chromatography; mass spectrometry; methanol; moieties; nitrogen; oxidation; pH; pollutants; scanning electron microscopy; soot; voltammetry; wastewater
Abstract:
... Hydrogen peroxide (H₂O₂) electrogenerated via two-electron oxygen reduction reaction at cathode plays an important role in electrochemical advanced oxidation processes for organic pollutants removal from wastewater. Herein, multi-walled carbon nanotubes and carbon black co-modified graphite felt electrode (MWCNTs-CB/GF) was prepared as an efficient cathode for H₂O₂ electrogeneration and amoxicilli ...
DOI:
10.1007/s11356-019-07358-2

37. Identification and analysis of characteristic tryptic peptides from porcine gelatin extracted with multi-stage batch processing

Author:
Xiao-Mei Sha; Zi-Zi Hu; Huang Xu; Lu-Zheng Zhang; Zong-Cai Tu
Source:
Food hydrocolloids 2020 v.101 pp. 105540
ISSN:
0268-005X
Subject:
batch systems; gelatin; hydrocolloids; hydroxylation; liquid chromatography; peptides; proline; swine; tandem mass spectrometry; temperature
Abstract:
... The extraction process significantly affects the characteristics and identification of gelatins. Here, three porcine gelatins were extracted using multi-stage batch processing by three extraction stages with temperatures of 50, 70, and 90 °C, respectively. Liquid chromatography-high-resolution mass spectrometry was used to investigate differences in the characteristic tryptic peptides derived from ...
DOI:
10.1016/j.foodhyd.2019.105540

38. Identification and characterization of in silico, in vivo, in vitro, and reactive metabolites of infigratinib using LC-ITMS: bioactivation pathway elucidation and in silico toxicity studies of its metabolites

Author:
Nasser S. Al-Shakliah; Mohamed W. Attwa; Adnan A. Kadi; Haitham AlRabiah
Source:
RSC advances 2020 v.10 no.28 pp. 16231-16244
ISSN:
2046-2069
Subject:
Lewis bases; acetonitrile; benzene; benzoquinones; biochemical pathways; computer simulation; dechlorination; fibroblast growth factor receptors; glucuronic acid; glutathione; hepatocytes; humans; hydroxylation; laboratory animals; liquid chromatography; liver; liver microsomes; mass spectrometry; metabolism; metabolites; neoplasm cells; oral administration; piperazine; potassium cyanide; prediction; rats; sulfates; toxicity; toxicity testing; urine
Abstract:
... Infigratinib (INF) is a novel, small molecule that is orally administered to inhibit human fibroblast growth factor receptors (FGFRs), which are a family of receptor tyrosine kinases that may be upregulated in different tumor cell types. On 6 January 2020, the FDA granted fast track designation to INF for first-line treatment of cholangiocarcinoma. Prediction of susceptible sites of metabolism and ...
DOI:
10.1039/c9ra10871h

39. Identification and determination of by‐products originating from ozonation of chlorpyrifos and diazinon in water by liquid chromatography–mass spectrometry

Author:
Yunhee Lee; Yun‐Ji Kim; Muhammad Saiful Islam Khan; Yun‐Cheol Na
Source:
Journal of separation science 2020 v.43 no.21 pp. 4047-4057
ISSN:
1615-9306
Subject:
chlorpyrifos; diazinon; equipment; hydrolysis; hydroxylation; liquid chromatography; oxidation; ozonation; ozone; separation; tandem mass spectrometry; thiophosphate
Abstract:
... The degradation of two organophosphates, chlorpyrifos and diazinon, in water using microplasma equipment to produce ozone and the identification of their products were studied by using liquid chromatography–mass spectrometry. The organophosphates gradually decreased with time and were completely removed after 10 min, and diazinon was degraded at a relatively fast rate compared to chlorpyrifos. The ...
DOI:
10.1002/jssc.202000584

40. Metabolomics with ¹⁵N Labeling for Characterizing Missing Monoterpene Indole Alkaloids in Plants

Author:
Ryo Nakabayashi; Tetsuya Mori; Noriko Takeda; Kiminori Toyooka; Hiroshi Sudo; Hiroshi Tsugawa; Kazuki Saito
Source:
Analytical chemistry 2020 v.92 no.8 pp. 5670-5675
ISSN:
1520-6882
Subject:
Catharanthus roseus; flowers; hydroxylation; image analysis; indole alkaloids; ions; isotope labeling; liquid chromatography; medicinal plants; metabolites; metabolome; metabolomics; monoterpenoids; nitrogen; petioles; principal component analysis; roots; stable isotopes; stems; tandem mass spectrometry
Abstract:
... Monoterpene indole alkaloids (MIAs) in medicinal plants remain uncharacterized owing to their complicated structure by metabolomics using liquid chromatography–tandem mass spectrometry (LC–MS/MS) despite their pharmaceutical importance. We demonstrate an untargeted metabolome analysis with ¹⁵nitrogen (N) labeling to characterize MIAs having an indolic skeleton in the flowers, leaves, petioles, ste ...
DOI:
10.1021/acs.analchem.9b03860

41. New insights into transformation pathways of a mixture of cytostatic drugs using Polyester-TiO2 films: Identification of intermediates and toxicity assessment

Author:
Eleni Evgenidou; Anna Ofrydopoulou; Neda Malesic-Eleftheriadou; Christina Nannou; Nina Maria Ainali; Evi Christodoulou; Dimitrios N. Bikiaris; George Z. Kyzas; Dimitra A. Lambropoulou
Source:
Science of the total environment 2020 v.741 pp. 140394
ISSN:
0048-9697
Subject:
Daphnia magna; aquatic organisms; aromatic compounds; comparative study; cyclophosphamide; ecotoxicology; environment; fluorouracil; hydroxylation; liquid chromatography; mass spectrometry; photocatalysis; photocatalysts; structure-activity relationships; tamoxifen; toxicity
Abstract:
... The photocatalytic activity of two bio-based polymer photocatalysts [poly(ethylene terephthalate)-TiO₂ (PET-TiO₂) and poly(L-lactic acid)-graphene oxide-TiO₂ (PLLA-GO-TiO₂)] towards Tamoxifen (TAM), Cyclophosphamide (CP), Cytarabine (CYT) and 5-Fluorouracil (5-FLU) removal was explored and compared. The highest photocatalytic activity for the degradation of the cytostatic drugs was accomplished by ...
DOI:
10.1016/j.scitotenv.2020.140394

42. Novel CuCo₂O₄ Composite Spinel with a Meso-Macroporous Nanosheet Structure for Sulfate Radical Formation and Benzophenone-4 Degradation: Interface Reaction, Degradation Pathway, and DFT Calculation

Author:
Yiping Wang; Haodong Ji; Wen Liu; Tianshan Xue; Chao Liu; Yuting Zhang; Longyan Liu; Qiang Wang; Fei Qi; Bingbing Xu; Daniel C.W. Tsang; Wei Chu
Source:
ACS applied materials & interfaces 2020 v.12 no.18 pp. 20522-20535
ISSN:
1944-8252
Subject:
benzophenones; cetyltrimethylammonium bromide; chemical bonding; cleavage (chemistry); cobalt; copper; copper nanoparticles; density functional theory; hot water treatment; hydroxyl radicals; hydroxylation; ions; leaching; liquid chromatography; mass spectrometry; nanosheets; sulfates
Abstract:
... A series of CuCo₂O₄ composite spinels with an interconnected meso-macroporous nanosheet morphology were synthesized using the hydrothermal method and subsequent calcination treatment to activate peroxymonosulfate (PMS) for benzophenone-4 (BP-4) degradation. As-prepared CuCo₂O₄ composite spinels, especially CuCo-H3 prepared by adding cetyltrimethylammonium bromide, showed superior reactivity for PM ...
DOI:
10.1021/acsami.0c03481

43. Red mud-activated peroxymonosulfate process for the removal of fluoroquinolones in hospital wastewater

Author:
Joohyun Kim; Gnougon Nina Coulibaly; Sunho Yoon; Aymen Amin Assadi; Khalil Hanna; Sungjun Bae
Source:
Water research 2020 v.184 pp. 116171
ISSN:
0043-1354
Subject:
chlorides; ciprofloxacin; flumequine; hospitals; hydroxylamine; hydroxylation; liquid chromatography; mineralization; nitrates; organic matter; oxidation; phosphates; research; solid wastes; sulfates; wastewater; water
Abstract:
... In this study, a novel peroxymonosulfate (PMS) activation method, which combines a solid waste (i.e., red mud, RM) and a reducing agent (i.e., hydroxylamine, HA), for the oxidative degradation of fluoroquinolones (FQs; i.e., flumequine (FLU) and ciprofloxacin (CIP)) in hospital wastewater (HW) was developed. The addition of HA into the PMS/RM suspension significantly enhanced FLU removal, owing to ...
DOI:
10.1016/j.watres.2020.116171

44. Residues of anilinopyrimidine fungicides and suspected metabolites in wine samples

Author:
G. Castro; L. Pérez-Mayán; I. Carpinteiro; M. Ramil; R. Cela; I. Rodríguez
Source:
Journal of chromatography 2020 v.1622 pp. 461104
ISSN:
0021-9673
Subject:
cyprodinil; food contamination; fungicide residues; glycosylation; grapes; hydroxylation; liquid chromatography; metabolites; pyrimethanil; red wines; solid phase extraction; tandem mass spectrometry; white wines; winemaking
Abstract:
... The coexistence of the anilinopyrimidine fungicides pyrimethanil (PYR) and cyprodinil (CYP), and suspected metabolites in wine samples was investigated by liquid chromatography (LC) with tandem mass spectrometry (MS/MS), based on triple quadrupole (QqQ) and quadrupole time-of-flight (QTOF) MS instruments. For the first time, quantitative data obtained after solid-phase extraction (SPE) of wine sam ...
DOI:
10.1016/j.chroma.2020.461104

45. Resolving Modifications on Sphingoid Base and N-Acyl Chain of Sphingomyelin Lipids in Complex Lipid Extracts

Author:
Xue Zhao; Gang Wu; Wenpeng Zhang; Mengqiu Dong; Yu Xia
Source:
Analytical chemistry 2020 v.92 no.21 pp. 14775-14782
ISSN:
1520-6882
Subject:
Caenorhabditis elegans; acetone; analytical chemistry; bicarbonates; brain; dissociation; hydroxylation; lipidomics; lipogenesis; liquid chromatography; mass spectrometry; sphingomyelins; sphingosine; swine
Abstract:
... Sphingomyelins (SMs) are an essential class of lipids widely existing in different organisms. The sphingoid base and N-acyl chain are two building blocks which can undergo different types of modifications during lipogenesis, including desaturation, hydroxylation, and methyl branching. Current lipidomic analysis methods cannot provide detailed information on these structural motifs. Herein, we deve ...
DOI:
10.1021/acs.analchem.0c03502

46. Simultaneous targeted and untargeted UHPLC-ESI-MS/MS method with data-independent acquisition for quantification and profiling of (oxidized) fatty acids released upon platelet activation by thrombin

Author:
Malgorzata Cebo; Jörg Schlotterbeck; Meinrad Gawaz; Madhumita Chatterjee; Michael Lämmerhofer
Source:
Analytica chimica acta 2020 v.1094 pp. 57-69
ISSN:
0003-2670
Subject:
analytical chemistry; biomarkers; blood platelets; chemical species; hydroxylation; liquid chromatography; mass spectrometry; oxidation; oxylipins; platelet activation; polyunsaturated fatty acids; quantitative analysis; thrombin; thromboxanes
Abstract:
... In this study, a combined targeted/untargeted UHPLC-ESI-QTOF-MS/MS method for the targeted quantitative analysis of the primary platelet lipid mediators thromboxane B2 (TXB2), 12S-hydroxy-5Z,8E,10E-heptadecatrienoic acid (HHT) and its oxidation product 12-keto-5Z,8E,10E-heptadecatrienoic acid (KHT) was developed, which allowed simultaneous untargeted profiling for the detection of other lipid biom ...
DOI:
10.1016/j.aca.2019.10.005

47. Studies on the phase I metabolites of the new designer drug 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidine-1-yl)butan-1-one (5-PPDI) in human urine

Author:
Ayumu Ishii; Kosuke Kusakabe; Noriyuki Kato; Shin-ichi Sasaki; Kenji Tsujikawa; Takeshi Wada
Source:
Forensic science international 2020 v.310 pp. 110214
ISSN:
0379-0738
Subject:
acetonitrile; biochemical pathways; constitutional isomers; cytotoxicity; designer drugs; diastereomers; forensic sciences; humans; hydroxylation; liquid chromatography; liquid-liquid extraction; metabolism; metabolites; moieties; quantitative analysis; stereoselectivity; tandem mass spectrometry; urinalysis; urine
Abstract:
... Pyrrolidinophenones (PPs) are synthetic cathinones containing a pyrrolidine ring that are used recreationally worldwide. Recently, many studies on the metabolism and cytotoxicity of PPs have been published. Here, we focus on new designer drug containing an indan skeleton, 1-(2,3-dihydro-1H-inden-5-yl)-2-(pyrrolidine-1-yl)butan-1-one (5-PPDI), because there have been no reports to date regarding th ...
DOI:
10.1016/j.forsciint.2020.110214

48. Transformation mechanisms of tetracycline by horseradish peroxidase with/without redox mediator ABTS for variable water chemistry

Author:
Yifei Leng; Jianguo Bao; Henglin Xiao; Dandan Song; Jiangkun Du; Sanjeeb Mohapatra; David Werner; Jun Wang
Source:
Chemosphere 2020 v.258 pp. 127306
ISSN:
0045-6535
Subject:
alcohols; correlation; degradation; demethylation; environment; enzyme activity; free radicals; hydrochemistry; hydroxylation; liquid chromatography; oxidation; pH; peroxidase; pollutants; sewage treatment; spectrometers; tandem mass spectrometry; tetracycline; wastewater treatment; water temperature
Abstract:
... The threat of antibiotics in the environment causing antibiotics resistance is a global health concern. Enzymes catalyze pollutant transformations, and how commercially available enzymes like horseradish peroxidase (HRP), with or without a redox mediator, may be used to degrade antibiotics in water treatment is of great interest. This work demonstrates tetracycline transformation by HRP, and how i ...
DOI:
10.1016/j.chemosphere.2020.127306

49. A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds

Author:
Dieter Schemeth; Nikoline J. Nielsen; Jan T. Andersson; Jan H. Christensen
Source:
Chemosphere 2019 v.235 pp. 175-184
ISSN:
0045-6535
Subject:
anion exchange; aromatic compounds; basins; bioavailability; carboxylation; databases; dicarboxylic acids; environmental factors; fatty acids; gas chromatography-mass spectrometry; hydroxylation; liquid chromatography; photooxidation; polycyclic compounds; runoff; screening; solid phase extraction; toxicity; weathering; Arctic region
Abstract:
... Polycyclic aromatic compounds (PACs) possess toxicity towards humans, and their presence in the environment is unwanted. Polar transformation products (TPs) are more mobile, and can be considered emerging contaminants, as they represent a more bioavailable carrier of the same toxic properties. Acidic TPs has been proposed as an important class of polar TPs. This study presents a tiered analytical ...
DOI:
10.1016/j.chemosphere.2019.06.149

50. Biodegradation Products of a Sulfonated Azo Dye in Aerobic Granular Sludge Sequencing Batch Reactors Treating Simulated Textile Wastewater

Author:
Rita D. G. Franca; M. Conceição Oliveira; Helena M. Pinheiro; Nídia D. Lourenço
Source:
ACS sustainable chemistry & engineering 2019 v.7 no.17 pp. 14697-14706
ISSN:
2168-0485
Subject:
aromatic amines; autoxidation; azo dyes; azorubine; batch systems; biodegradation; deamination; electrospray ionization mass spectrometry; hydrodynamics; hydroxylation; intermediate product; liquid chromatography; metabolites; nitrates; sludge; textile mill effluents
Abstract:
... This study focused on the biodegradation of an azo dye (Acid Red 14, AR14) in two anaerobic–aerobic sequencing batch reactors (SBRs) treating synthetic textile wastewater, operated with aerobic granular sludge under different hydrodynamic regimens. The aim was to investigate the fate of the anaerobic AR14 breakdown products (aromatic amines) during the SBRs’ aerobic reaction phase. Specifically, l ...
DOI:
10.1021/acssuschemeng.9b02635