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- Jo, Eun‐Kyeong, et al. Show all 4 Authors
- Phytotherapy research 2017 v.31 no.1 pp. 152-163
- Toll-like receptor 4; Withania somnifera; anti-inflammatory activity; chemical elements; cytokines; drugs; leaves; lipopolysaccharides; macrophages; medicinal plants; mitogen-activated protein kinase; molecular models; mortality; pathogen-associated molecular patterns; signal transduction; transcription factor NF-kappa B
- ... Innate inflammations are dominant causes of poor health and high mortality. The pathogen‐associated molecular pattern and lipopolysaccharide (LPS) are sensed by immune cells through activation of toll‐like receptor 4 leading to mitogen‐activated protein kinases (MAPKs) and NF‐κB activations. Controlled MAPK and Nf‐κB inhibitors have been proposed as potential antiinflammatory drugs. Withania somni ...
- Jo, Eun-Kyeong, et al. Show all 8 Authors
- The journal of microbiology 2015 v.53 no.12 pp. 864-874
- Mycobacterium chelonae; Toll-like receptor 2; animal models; blood serum; cell-mediated immunity; chemokine CCL2; chemokine CCL5; genes; human diseases; macrophages; messenger RNA; mice; microbial load; monitoring; mycobacterial diseases; protein synthesis; reactive oxygen species; signal transduction; spleen; transcription factor NF-kappa B
- ... Mycobacterium chelonae (Mch) is an atypical rapidly growing mycobacterium (RGM) that belongs to the M. chelonae complex, which can cause a variety of human infections. During this type of mycobacterial infection, macrophagederived chemokines play an important role in the mediation of intracellular communication and immune surveillance by which they orchestrate cellular immunity. However, the intra ...
- Jo, Eun-Kyeong, et al. Show all 16 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.20 pp. 7729-7734
- Mycobacterium smegmatis; Mycobacterium tuberculosis; acetylation; amines; aminoglycosides; autophagy; drug resistance; immune response; inflammation; macrophages; mitogen-activated protein kinase; pathogens; phosphoprotein phosphatase; phosphorylation; proteins; reactive oxygen species; tuberculosis
- ... The intracellular pathogen Mycobacterium tuberculosis (Mtb) causes tuberculosis. Enhanced intracellular survival (Eis) protein, secreted by Mtb, enhances survival of Mycobacterium smegmatis (Msm) in macrophages. Mtb Eis was shown to suppress host immune defenses by negatively modulating autophagy, inflammation, and cell death through JNK-dependent inhibition of reactive oxygen species (ROS) genera ...
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