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bioavailability; biomechanics; blood serum; bone health; bone metabolism; bone strength; dietary supplements; males; metabolites; microstructure; placebos; rats; vitamin D deficiency; whey; whey protein isolate
Abstract:
... Vitamin D deficiency is a global health issue with consequences for bone health. Complexation of vitamin D₃ with specific whey proteins might increase the bioavailability and enhance the effect of dietary supplementation on health outcomes. The current rat study was set up to investigate if complexation of vitamin D₃ with whey protein isolate (WPI) or β-lactoglobulin (B-LG) increases bioavailabili ...
... It is imperative to evaluate precise nutrient requirements of animals in order to optimize productivity and minimize feed cost and nutrient excretions. The current non-phytate phosphorus (NPP) recommendation for broilers is based on the papers published 30 years ago. However, today’s commercial birds are quite different from those before 30 years. Therefore, the present experiment was conducted wi ...
adipocytes; adiposity; analysis of variance; arachidonic acid; blood serum; bone density; bone resorption; bone strength; dual-energy X-ray absorptiometry; energy intake; erythrocytes; fatty acid composition; femur; gas chromatography; high fat diet; laboratory animals; leptin; long chain polyunsaturated fatty acids; males; metabolism; micro-computed tomography; mineral content; obesity; rats; visceral fat
Abstract:
... Long-chain polyunsaturated fatty acids modulate bone mass and adipocyte metabolism. Arachidonic acid (AA, C20:4 n-6) is elevated in obesity and postulated to stimulate bone resorption. This study aimed to determine the effect of AA on bone mass, quality, and adiposity in diet-induced obesity during growth. Male Sprague–Dawley rats (n=42, 4-week) were randomized into groups fed a control diet (CTRL ...
bone density; bone mineralization; transferrin; males; binding proteins; bone strength; microstructure; dietary fiber; blood serum; tibia; calcium; nutrient deficiencies; histology; iron deficiency anemia; rats; inulin; bone resorption; heme iron; osteoclasts; liver; mineral metabolism; nutritional status; experimental diets; nutrient availability; hemoglobin; magnesium; animal models
Abstract:
... Feeding mineral-deficient diets enhances absorptive efficiency as an attempt of the body to compensate for the lack of an essential nutrient. Under certain circumstances, it does not succeed; and nutritional deficiency is produced. Our hypothesis was that inulin-type fructans (ITF), which are known to affect mineral absorption, could increase Ca and Fe bioavailability in Ca- and Fe-deficient rats. ...
bone resorption; bone strength; cathepsin K; diet; glucose; health status; insulin resistance; knockout mutants; males; mice; mitochondria; molecular models; resveratrol; tibia
Abstract:
... SCOPE: While resveratrol (RSV) is associated with the prevention of high‐fat (HF) diet‐induced insulin resistance, the effects on bone health combined with an HF‐diet is unknown. Therefore, we determined the effect of RSV on bone microarchitecture in the presence of an HF‐diet, while also elucidating molecular adaptations within bone that could contribute to bone health status. METHODS AND RESULTS ...
Asians; adolescence; adolescents; adulthood; adults; blood serum; bone mineralization; bone strength; children; dose response; females; males; medicine; mineral content; muscles; observational studies; randomized clinical trials; risk; vitamin D; youth
Abstract:
... A significant number of children and adolescents worldwide have low serum 25(OH)D values relative to the 2010 Institute of Medicine criteria. Since approximately 90% of adult bone mineral content (BMC) is accrued by the end of adolescence, and approximately 40% of adult BMC accumulated during the 4 years surrounding peak BMC velocity, low circulating 25(OH)D during this time may attenuate gains in ...
bone strength; cardiorespiratory fitness; cardiovascular diseases; diabetic complications; males; metabolism; motor neurons; muscle strength; muscles; nerve tissue; patients; peripheral nervous system diseases; physical activity; regression analysis; vibration
Abstract:
... Apart from late motor nerve dysfunction, factors affecting muscle strength in diabetes are largely unknown. This study was aimed at assessing muscle strength correlates in diabetic subjects encompassing a wide range of peripheral nerve function and various degrees of micro and macrovascular complications.Four-hundred consecutive patients with type 1 and 2 diabetes (aged 46.4 ± 13.9 and 65.8 ± 10.3 ...
blood serum; bone density; bone strength; cages; calcium; calcium hydrogen phosphate; diet; duodenum; gene expression; genes; growth performance; inorganic phosphorus; males; sodium phosphate; symporters; tibia; weight gain
Abstract:
... An experiment was conducted to investigate the effect of dietary non-phytate phosphorus (NPP) level on growth performance, bone characteristics and phosphorus metabolism-related gene expressions, so as to evaluate the dietary NPP requirement of broiler chicks fed a conventional corn-soybean meal diet from 1 to 21 d of age. A total of 540 day-old Arbor Acres male chicks were randomly allocated to o ...
... The study was conducted to determine the true Ca absorption coefficients and growth performance of piglets fed diets containing different sources of Ca. In the metabolism study, 30 piglets uncastrated, with initial weight averages of 20.52 ± 1.84kg, were assigned to 5 treatments with 6 piglets per treatment in a randomized complete block design. A basal diet was formulated to meet the piglets nutr ...
antioxidant activity; antioxidants; blood serum; body weight changes; bone mineralization; bone strength; broiler chickens; dietary supplements; feed conversion; feed intake; glutathione peroxidase; lipid peroxidation; males; mineral content; research; slaughter; superoxide dismutase; tibia; tropics
Abstract:
... Two experiments were conducted to study the performance, antioxidant activity, and bone mineral variables in broilers fed organic trace minerals (OTM) at lowered concentrations in the diet. In experiment 1, a total of 1500 day-old broiler male chicks were randomly distributed into six groups with 10 replicates of 25 chicks each and housed in floor pens (1.90 × 1.22 m). One group was fed the maize- ...
... Two experiments were conducted to evaluate the efficacy of Trichoderma reesei derived phytase for pigs fed diets with fixed calcium to total phosphorus ratios (1.5:1). In Exp. 1, 280 weaned pigs (initial BW of 10.32+/-1.94 kg) were allocated to one of five dietary treatments on the basis of weight and gender in a randomized complete block design. Treatments were the low phosphorus (0.6% Ca, 0.4% t ...
abdominal fat; average daily gain; blood serum; bone strength; breast muscle; broiler chickens; carcass yield; cholecalciferol; citric acid; diet; growth performance; males; phytases; phytic acid
Abstract:
... This study investigated effect of various combinations of phytase, citric acid (CA), and vitamin D₃ (D₃) on phytate P utilization as evaluated by growth performance, serum minerals, and bone characteristics in broiler chickens fed the diet severely limited in non-phytate P. A total of 585 ten-day-old male broiler chickens were allocated to 9 diets from 11 to 38 d of age. There were a positive cont ...
alkaline phosphatase; biomarkers; blood; bone density; bone health; bone strength; collagen; computed tomography; diet; dual-energy X-ray absorptiometry; functional foods; hips; humans; males; plums; prunes; tibia; ulna
Abstract:
... Several male animal studies have demonstrated bone-protective effects of dried plum; however, no human male study has evaluated the effect of dried plum on bone health. We conducted a randomized controlled clinical study to test if daily inclusion of 100 g of dried plum in the diet positively influenced bone mineral density (BMD), bone strength, and bone biomarkers in men. Sixty-six men were rando ...
biomechanics; body weight; bone strength; brittleness; cadmium; femur; gene expression; high fat diet; males; research; trace elements
Abstract:
... This study investigated the effects of combined exposure to low-dose cadmium and high-fat diet on femoral bone quality in male mice. Eight-week-old male SPF C57BL/6J mice were randomly divided into four groups: normal control group (Con), low-cadmium group (Cd), high-fat diet group (HFD), and high-fat diet plus low-dose cadmium group (HFD + Cd); the second and fourth groups were treated intraperit ...
biotechnology; bone density; cages; calcium; energy; glucocorticoids; males; models; osteopenia; osteoporosis; protein content; protein intake; strength training; therapeutics; weight gain
Abstract:
... We examined the effects of a voluntary resistance exercise (climbing) together with high-protein snacks (60% protein) on bone mass and strength in rats given glucocorticoid-injections (2 mg/kg/day) as a model of age-related osteopenia. Fifty-two male Sprague-Dawley rats, 8 weeks age, were assigned to exercise or sedentary groups. These groups were further divided into groups that received no snack ...
... The objective of present study was to investigate the effects of alpha-lipoic acid (ALA) dietary supplementation on the behavior, physiological and oxidant stress indicators, and bone quality in broilers under high stocking density (HSD) stress. A total of one thousand eight hundred 22-day-old Arbor Acres male broiler chicks were randomly allocated to 18 pens (2.97 × 2.03 m) in 3 groups: 14 birds/ ...
... The effects of desalted duck egg white peptides (DPs), phosphorylated DPs (PDPs) and DPs–calcium complexes (DPs-Ca) on calcium absorption in vivo were investigated. Ninety fast-growing male rats were divided into 10 groups and treated with different dosages of CaCO3, calcium gluconate, DPs-Ca as well as CPPs, DPs and PDPs supplemented with CaCO3. Eight-week oral administration results indicated th ...
... To investigate effects of dietary calcium (Ca) and phosphorus (P) levels and 25-hydroxycholecalciferol (25OHD₃) supplementation on performance and bone properties of broiler starters, 224 male Arbor Acre broilers were used in a 21-d trial. Broilers were allotted to one of four treatments in a 2 × 2 factorial arrangement including diets either normal or low in Ca and P, which were further supplemen ...
C.A. Ruiz-Feria; J.J. Arroyo-Villegas; A. Pro-Martinez; J. Bautista-Ortega; A. Cortes-Cuevas; C. Narciso-Gaytan; A. Hernandez-Cazares; J. Gallegos-Sanchez
abdominal fat; bone strength; lameness; leg weakness; males; sedentary lifestyle
Abstract:
... Lameness or leg weakness is becoming an important problem in broilers selected for rapid growth, and although the causes are not known, sedentary behavior could be a cause. Two experiments were conducted to study the effects of distance and the presence of ramps between resources (feed and water) on bone and tendon strength, ability to stand, and productive performance. In experiment 1, straight r ...
... Serum concentrations of 25-hydroxycholecalciferol [25(OH)D₃] in broiler embryos at 19 d of incubation(doi) have been shown to increase 3 times by the in ovo injection of 0.60 μg 25(OH)D₃ on 18 doi. In this trial, effects of the injection of 25(OH)D₃ at 18 doi on the yolks and sera of male and female Ross × Ross 708 broiler embryos were assessed. On 18 doi, embryonated eggs that were set in a singl ...
Shaw, Ashley L.; Blake, John P.; Moran, Edwin T. Jr.
ISSN:
1346-7395
Subject:
poults; diet; phytases; tibia; calcium; nutrients; males; feed intake; growth performance; bone mineralization; chicks; body weight changes; bone strength; phosphorus
Abstract:
... An experiment was conducted to evaluate the effects of two commercial phytases on performance and bone mineralization of male broilers from two commercial strains when included into a diet marginal in both calcium (Ca) and non-phytate phosphorus (npP). Male chicks from two broiler strains (Strains 1 and 2; 320 of each) were placed on fresh bedding across 64 pens (10 birds/pen with 8 replicates/tre ...
body weight; bone strength; broiler chickens; broiler feeding; diet; feed conversion; feed intake; growth performance; males; manganese; regression analysis; tibia
Abstract:
... The objective of the current study was to evaluate the impact of increasing manganese (Mn) hydroxychloride on growth performance and tibia strength of male broilers fed corn-soy diets. A total of 35 Ross 708 male broilers per pen were assigned to dietary treatments containing Mn hydroxychloride at 0, 40, 80, 120, and 160 ppm, respectively. Broilers were fed for a 55 d period. Performance parameter ...
... Senile osteoporosis (SOP) is a related disease of systematic degenerative changes in bones during natural aging. Increasing age is an important factor in its pathogenesis. This experiment was to evaluate the comprehensive effect of calcium with vitamin D3 (CaD) on SOP based on multilayer perception (MLP)–artificial neural network (ANN) methods. 15-month-old male Sprague-Dawley rats were administer ...
Mustafa F. Alkhouli; Jun Hung; Michaela Squire; Miranda Anderson; Monica Castro; Jeganathan R. Babu; Layla Al-Nakkash; Tom L. Broderick; Jeffrey H. Plochocki
Alzheimer disease; alternative medicine; animal models; bone fractures; bone strength; diet; elderly; exercise; fluorescence; geometry; males; mice; osteoporosis; pellets; resveratrol; risk; tibia
Abstract:
... BACKGROUND: Alzheimer’s disease (AD) and osteoporosis are progressive diseases that affect the elderly population. Both conditions are associated with fracture risk that is greater than twice that of the healthy population. Resveratrol and exercise are two treatments that have been linked with attenuation of age-related diseases, including the risk of bone fractures. In this study, we test the hyp ...
German Shepherd; bone strength; dogs; histopathology; males; mandible (bone); signs and symptoms (animals and humans); veterinary dentistry
Abstract:
... A nine-year-old, male German shepherd dog was presented with a firm, discrete mass lingual to the interdental space of the mandibular left third and fourth premolars. The lesion was excised and diagnosed as fibrous dysplasia of bone based on histopathologic examination. Fibrous dysplasia of bone is a rare, non-aggressive, radiolucent, non-neoplastic lesion considered developmental in origin. Usual ...
adults; bone strength; bones; females; genetic variation; genome; males; mice
Abstract:
... We examined femora from adult AXB/BXA recombinant inbred (RI) mouse strains to identify skeletal traits that are functionally related and to determine how functional interactions among these traits contribute to genetic variability in whole-bone stiffness, strength, and toughness. Randomization of A/J and C57BL/6J genomic regions resulted in each adult male and female RI strain building mechanical ...
Large White; analysis of variance; asymmetry; biomechanics; bone density; bone strength; dual-energy X-ray absorptiometry; femur; gait; legs; males; tibia; toms
Abstract:
... Leg problems have become more frequent in fast-growing turkeys. The objective of this study was to evaluate the effects of common leg defects on kinetic parameters of gait and biomechanical properties of bone. Nine hundred, day-old, male, Large White turkeys were raised in 48 floor pens. At 42 d of age, turkeys were divided into four categories of leg condition as determined by visual evaluation: ...
bone density; bone metabolism; bone strength; experimental diets; femur; gene expression; high fat diet; males; messenger RNA; muscles; osteoporosis; rats; risk; sarcopenia; skeletal muscle; transcription factors; visceral fat; vitamin D
Abstract:
... Vitamin D insufficiency is associated with a greater risk of osteoporosis and also influences skeletal muscle functions, differentiation and development. The present study investigated the influences of vitamin D restriction on the body composition, bone and skeletal muscle in rats fed a high-fat diet. Sprague–Dawley strain male rats (11weeks old) were divided into four groups and fed experimental ...
... Calcium is chelated by phytic acid and forms phytate-mineral complexes reducing Ca availability and the ability of phytase to hydrolyze phytate. An increased Ca concentration in the gut favors the activity of Clostridium perfringens (C. perfringens). Therefore, it was hypothesized that high dietary calcium with high dietary phytase would decrease serum Ca and P and bone mineralization during necro ...
animal models; anti-inflammatory activity; blood serum; body weight; bone health; bone metabolism; bone strength; cholecalciferol; chronic exposure; colon; diet; females; femur; gene expression; humans; idiopathic diseases; inflammation; inflammatory bowel disease; interleukin-10; interleukin-6; knockout mutants; lactation; males; mice; mineral content; pregnancy; progeny; vitamin status; weaning; young adults
Abstract:
... Inflammatory bowel disease (IBD) is an idiopathic disease that can impair bone metabolism. Low vitamin D status has been implicated in its progress. This study used interleukin (IL)-10 knockout (KO) mice, that develop an intestinal inflammation when housed in a non-sterile environment, to determine if supplementation with vitamin D₃ throughout life could mitigate inflammation and attenuate the low ...
bioavailability; biotechnology; bone density; bone strength; calcium; cheeses; energy; femur; lumbar spine; males; milk; osteoporosis
Abstract:
... We investigated the calcium bioavailability of milk calcium, taken with or without cheese. Twenty-four 6-week-old male rats for a meal-feeding experiment were trained to consume an AIN-76 diet within 2 h (2 times per day) for 2 weeks. The rats were then divided into three experimental groups, each fed 2 types of experimental diets: Control group, Cheese group, and Ca-Cheese group. The rats were ea ...
bone formation; bone fractures; bone strength; callus; chondrogenesis; genes; males; mechanical properties; mice; micro-computed tomography; milk; nutrient content; patients; protein supplements; proteins; radiography; tap water; tibia; whey
Abstract:
... There is an unmet need for agents that can stimulate bone healing. The goal of this study was to evaluate the effects of basic proteins from milk whey (milk basic protein [MBP]) on fracture healing in mice.Closed tibial transverse fractures were generated in 6-wk-old male C3 H/HeJ mice given either tap water or MBP-supplemented water for 3, 7, 14, 28, and 56 d after fracture generation. The tibial ...
turkeys; femur; length; bone fractures; body weight; normal values; bone strength; torsional strength; males
Abstract:
... Morphologic and torsional mechanical properties of femora were evaluated in three groups of turkeys to determine whether turkeys that incurred femoral fracture have different radiographic, morphologic, and torsional mechanical properties than do turkeys without femoral fracture, and if body weight was a factor differentiating affected and nonaffected turkeys. Nine turkeys with unilateral femoral f ...
microstructure; soybean products; vertebrae; males; gender differences; ovariectomy; mice; bone density; genistein; animal models; castration; femur; daidzein; neonates; infant formulas; bone mineralization; bone strength; females; diethylstilbestrol
Abstract:
... Neonatal exposure to soy isoflavones at levels similar to that of infants fed soy protein formula resulted in higher bone mineral density (BMD), improved bone structure, and greater bone strength at young adulthood in female CD-1 mice (1,2). Our objective in this study was to determine whether these improvements in bone quantity and quality at 4 mo of age provide protection against the deteriorati ...
25-hydroxycholecalciferol; body weight changes; bone strength; breast meat; calcium; canthaxanthin; carcass yield; color; diet; feed conversion; feed intake; feeds; gait; lipid peroxidation; males; pH; phosphorus; pigmentation; tibia; variance; weight loss
Abstract:
... The objective of this study was to evaluate the effect of canthaxanthin (CTX) associated with 25-hydroxycholecalciferol (25-OH-D3) in the feed of male broilers. A total of 1500 one-day-old Cobb-500TM males were used, distributed in a completely randomized design, totaling two treatments with fifteen replicates of 50 birds each. The treatments were: CD - control diet and CTX+ 25-OH-D3 - control die ...
... This study investigates the effects of Trametes versicolor (L.:Fr.) Pilát (TVP, also known as Yunzhi) on bone properties in diabetic rats. Forty-five male Wistar rats (8 weeks old) were fed either a chow diet (control) or a high-fat diet throughout the study period of 28 days. Animals in the high-fat-diet group were injected with nicotinamide and streptozotocin to induce diabetes mellitus (DM). Th ...
blood serum; bone density; bone metabolism; bone strength; dual-energy X-ray absorptiometry; females; high energy diet; males; micro-computed tomography; mineralization; obesity; progeny; rats; strength (mechanics); tibia
Abstract:
... Our study aimed to verify the hypothesis of the existence of a programming effect of parental obesity on the growth, development and mineralization of the skeletal system in female and male rat offspring on the day of weaning. The study began with the induction of obesity in female and male rats of the parental generation, using a high-energy diet (group F). Females and males of the control group ...
Mariana M. Saldanha; Itallo C.S. Araújo; Marcela V. Triguineli; Diego P. Vaz; Felipe N.A. Ferreira; Juliano D.S. Albergaria; Dalton O. Fontes; Leonardo J.C. Lara
... The objective of this study was to evaluate the relative bioavailability (RB) of manganese (Mn) proteinate compared to Mn sulfate for broilers fed a diet based on corn and soybean meal for 20 d. The diets of 1,350 male Cobb broilers were supplemented with 0, 35, 70, 105, or 140 mg of Mn/kg of feed in the form of Mn sulfate or Mn proteinate. Weight gain, feed intake, feed conversion, bone strength, ...
... This study was conducted to assess the effects of omitting vitamin (VIT) and trace mineral (TRM) premixes from the finisher diet on growth performance, antibody production against Newcastle disease (ND) vaccination, leg bone strength and incidence of foot pad dermatitis (FPD) in male and female broiler chickens. Birds were raised on floor pens in a naturally ventilated house using wood shavings as ...
body weight; bone strength; casein; compensatory growth; food consumption; growth plate; humerus; males; micro-computed tomography; microstructure; milk; protein intake; rats; weight gain; whey; whey protein
Abstract:
... The aim of the present study was to determine whether the type of protein ingested influences the efficiency of catch-up (CU) growth and bone quality in fast-growing male rats. Young male Sprague–Dawley rats were either fed ad libitum (controls) or subjected to 36 d of 40 % food restriction followed by 24 or 40 d of re-feeding with either standard rat chow or iso-energetic, iso-protein diets conta ...
... Bone microarchitecture, bone mineral density (BMD), and bone strength are affected positively by impact activities such as running; however, there are discrepancies in the magnitude of these effects. These inconsistencies are mainly a result of varying training protocols, analysis techniques, and whether or not the skeletal sites measured are weight bearing. This study’s purpose was to determine t ...
Arthrospira platensis; Spirulina; adverse effects; antioxidant activity; antioxidants; bone metabolism; bone strength; casein; children; developmental stages; dietary supplements; digestibility; functional foods; hormone replacement therapy; males; models; nutrients; parathyroid hormone; protein content; protein sources; rats; skeletal development; somatotropin; supply
Abstract:
... In recent years, growth hormone deficiency in children has been treated with hormone therapy despite the possible significant side effects. Therefore, it was deemed beneficial to develop functional foods or dietary supplements for safely improving children’s growth. Spirulina platensis is known for its high antioxidant, anti-aging, anti-cancer, and immunity-enhancing properties, as well as its hig ...
animal disease models; antioxidant activity; blood serum; bone density; bone formation; bone resorption; bone strength; castration; dietary supplements; elderly; enzyme activity; euthanasia; females; femur; glutathione peroxidase; green tea; liver; males; microstructure; osteoporosis; ovariectomy; polyphenols; postmenopause; rats; testosterone; tibia
Abstract:
... Recent studies show that green tea polyphenols (GTP) attenuate bone loss and microstructure deterioration in ovariectomized aged female rats, a model of postmenopausal osteoporosis. However, it is not known if such an osteo-protective role of GTP is demonstrable in androgen-deficient aged rats, a model of male osteoporosis. We evaluated the efficacy of GTP in mitigation of bone loss and microstruc ...
... Osteoporosis reduces the skeletal strength and increases the risk for fracture. It is an underdiagnosed disease in men. Annatto tocotrienol has been shown to improve bone structural indices and increase expression of bone formation genes in orchidectomized rats. This study aimed to evaluate the effects of annatto tocotrienol on biomechanical strength and calcium content of the bone in orchidectomi ...
broiler chickens; locomotion; mash feed; females; body weight; animal welfare; males; gender differences; nutrient density; pelleted feeds; bone density; walking; photoperiod; skeleton; gait; broiler feeding; bone strength
Abstract:
... The aim of this study was to examine the main and interaction effects of 3 dietary nutrient densities (low-, medium-, high-density), 2 feed forms (mash, pellet), and 2 lighting programs (20L:4D, 12L:12D) on the walking ability and skeletal quality of broiler chickens raised to a young age (35 d). Forty-eight birds per treatment (nutrient density x feed form x lighting program subclass) were random ...
biochemical pathways; blood composition; body weight; bone formation; bone strength; broiler chickens; broiler feeding; diet; excreta; excretion; farms; feed conversion; feed intake; femur; growth and development; health status; males; manganese; manganese monoxide; mineral content; morphometry; nanoparticles; physicochemical properties; slaughter
Abstract:
... Manganese in animal organisms is responsible for proper bone formation and many biochemical processes. The aim of the study was to determine the effect of manganese oxide nanoparticles (NanoMn₂O₃) as a mineral additive to the feed mixture on the growth, slaughter characteristics, femur bone strength, mineral content of tissues and Mn excretion. The male chickens were randomly divided between a con ...
... The effects of dietary boron (B) (from boric acid [BA]) on bone strength were evaluated using male F344 rats. B was administered by dietary admixture of BA to NIH-07 feed at concentrations of 200, 1000, 3000, and 9000 ppm. The latter two levels were found in previous studies to be reproductively toxic to both males and the developing fetus. The first two levels are below and just at, respectively, ...
anti-inflammatory activity; anti-inflammatory agents; bone resorption; bone strength; cytokines; dose response; high fat diet; inflammation; males; metabolic syndrome; microstructure; osteoporosis; rats
Abstract:
... Inflammation is a possible mediator of the relationship between metabolic syndrome (MetS) and osteoporosis. Palm tocotrienol, an anti-inflammatory agent, has been reported to exert beneficial effects for the treatment of MetS and osteoporosis individually. This study aimed to investigate the potential role of palm tocotrienol in preventing both MetS and bone loss in male rats via alleviating the i ...
Jason D. Guss; Erik Taylor; Zach Rouse; Sebastian Roubert; Catherine H. Higgins; Corinne J. Thomas; Shefford P. Baker; Deepak Vashishth; Eve Donnelly; M. Kyla Shea; Sarah L. Booth; Rodrigo C. Bicalho; Christopher J. Hernandez
... The genetic components of microbial species that inhabit the body are known collectively as the microbiome. Modifications to the microbiome have been implicated in disease processes throughout the body and have recently been shown to influence bone. Prior work has associated changes in the microbial taxonomy (phyla, class, species, etc.) in the gut with bone phenotypes but has provided limited inf ...
acid phosphatase; alkaline phosphatase; animal models; biomechanics; blood sampling; blood serum; bone density; bone formation; bone resorption; bone strength; calcium; cyclophosphamide; diet; intravenous injection; laboratory animals; males; micro-computed tomography; osteoblasts; osteoclasts; osteopenia; osteoporosis; phosphates; rats; strontium; tibia
Abstract:
... The purpose of this study was to determine whether treatment with strontium ranelate (SrR) can restore bone mass and strength at a skeletal site with established osteopenia in chemotherapy-induced rats. Forty-five Sprague-Dawley male rats were randomly assigned to three study groups (n = 15 rats per group): normal rats (control group), osteopenic rats (chemo group), and osteopenic rats with SrR (c ...
... Two experiments were conducted to study the effect of standardized ileal digestible (SID) leucine and valine levels on tibiotarsus bone characteristics and the incidence of tibial dyschondroplasia of broilers from day 1 to 21 (Experiment I) and day 21 to 42 post‐hatch (Experiment II). Each experimental phase was evaluated independently. In both experiments, a total of 1,500 one‐day‐old Cobb 500 ma ...
... This study aimed to evaluate the effects of okara inclusion in diet for growing broilers on performance, carcass yield, blood and bone variables, quality and lipid oxidation of meat, and economic viability. For that, 575 Cobb 21-d-old male broilers were distributed in a completely randomized design with four levels of okara inclusion (25, 50, 75, and 100 g of okara kg⁻¹ diet) and a control group w ...
alkaline phosphatase; animal disease models; biomechanics; bone density; bone formation; bone resorption; bone strength; collagen; dose response; gene expression; gene expression regulation; genes; high fat diet; in vitro studies; laboratory animals; males; messenger RNA; microstructure; obesity; osteoblasts; peptides; protein synthesis; proteinase inhibitors; rats; serine proteinases; signal transduction; transcription factors
Abstract:
... BACKGROUND: Visceral adipose tissue-derived serine protease inhibitor (vaspin), an adipose-derived hormone, exhibits various biological functions. Recently, studies showed that vaspin is closely related to bone metabolism. However, how vaspin influences bone formation and its underlying mechanisms in high fat-induced obese rats and rat primary osteoblasts (OBs) are not fully understood. In this st ...
... The influence of dietary vitamin D₃ (VD3) levels on growth, bone performance, and duodenal type IIb sodium-dependent phosphate cotransporter (NaPi-IIb) genes in broiler chicken were studied. One-day-old male Ross308 broilers (n = 432) were allocated into 6 treatment groups with each group consisting of 6 cage pens. Each treatment group received diet containing different amounts of VD3 (80, 200, 50 ...