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- Dou, Tongyi, et al. Show all 8 Authors
- Chemical communications 2019 v.55 no.30 pp. 4311-4314
- catechol O-methyltransferase; chemical reactions; ligands; lysine; mass spectrometry; prediction; receptors
- ... Herein we provide a mass spectrometry-based lysine reactivity profiling strategy to monitor the ligand modulation of protein receptors, which is achieved by active dimethyl labeling of lysine residues and comparison of the alterations of labeling reactivity during ligand binding. The small-molecule ligand modulation patterns on the catechol-O-methyltransferase and the N-methyl-d-aspartate receptor ...