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- Barsegov, Valeri, et al. Show all 12 Authors
- Biomacromolecules 2016 v.17 no.8 pp. 2522-2529
- atomic force microscopy; capsid; encapsulation; eukaryotic cells; mass spectrometry; mechanical properties; molecular models; organelles; packaging; prokaryotic cells; viruses
- ... Prokaryotes mostly lack membranous compartments that are typical of eukaryotic cells, but instead, they have various protein-based organelles. These include bacterial microcompartments like the carboxysome and the virus-like nanocompartment encapsulin. Encapsulins have an adaptable mechanism for enzyme packaging, which makes it an attractive platform to carry a foreign protein cargo. Here we inves ...
- Barsegov, Valeri, et al. Show all 6 Authors
- Journal of the American Chemical Society 2012 v.134 no.50 pp. 20396-20402
- energy; fibrin; humans; mechanical properties; models; phase transition
- ... We characterized the α-to-β transition in α-helical coiled-coil connectors of the human fibrin(ogen) molecule using biomolecular simulations of their forced elongation and theoretical modeling. The force (F)–extension (X) profiles show three distinct regimes: (1) the elastic regime, in which the coiled coils act as entropic springs (F < 100–125 pN; X < 7–8 nm); (2) the constant-force plastic regim ...
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- Barsegov, Valeri, et al. Show all 5 Authors
- The Journal of physical chemistry 2012 v.116 no.29 pp. 8545-8555
- biomechanics; cell adhesion; cell division; cylinders; deformation; depolymerization; kinesin; mechanical properties; microtubules; models; physical chemistry; polymers; shrinkage; tubulin
- ... Large-size biomolecular systems that spontaneously assemble, disassemble, and self-repair by controlled inputs play fundamental roles in biology. Microtubules (MTs), which play important roles in cell adhesion and cell division, are a prime example. MTs serve as ″tracks″ for molecular motors, and their biomechanical functions depend on dynamic instabilitya stochastic switching between periods of ...