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- Tanaka, Junichi, et al. Show all 14 Authors
- Biochemical and biophysical research communications 2019 v.512 no.2 pp. 145-149
- bone formation; bone morphogenetic proteins; cell division; genes; guanosinetriphosphatase; knockout mutants; mice; morphogenesis; phenotype; skeletal development; skull
- ... Cdc42 (cell division cycle 42) is ubiquitously expressed small GTPases belonging to the Rho family of proteins. Previously, we generated limb bud mesenchyme-specific Cdc42 inactivated mice (Cdc42 conditional knockout mice; Cdc42 fl/fl; Prx1-Cre), which showed short limbs and cranial bone deformities, though the mechanism related to the cranium phenotype was unclear. In the present study, we invest ...
- Tanaka, Junichi, et al. Show all 11 Authors
- Biochemical and biophysical research communications 2016 v.470 pp. 813-817
- actin; body weight; bone formation; cartilage; cell movement; chondrocytes; collagen; crossing; cytoskeleton; gene expression; growth plate; guanosinetriphosphatase; mice; transgenic animals
- ... Cdc42, a small Rho GTPase family member, has been shown to regulate multiple cellular functions in vitro, including actin cytoskeletal reorganization, cell migration, proliferation, and gene expression. However, its tissue-specific roles in vivo remain largely unknown, especially in postnatal cartilage development, as cartilage-specific Cdc42 inactivated mice die within a few days after birth. In ...