Jump to Main Content
- Roychowdhury, Sanjoy, et al. Show all 6 Authors
- Molecular Immunology 2016 v.72 pp. 9-18
- apoptosis; caudal vein; complement; cytokines; esterases; ethanol; hepatocytes; immunoglobulin M; inflammation; liquid diet; liver; liver diseases; mice
- ... Ethanol feeding in mice activates complement via C1q binding to apoptotic cells in the liver; complement contributes to ethanol-induced inflammation and injury. Despite the critical role of C1q in ethanol-induced injury, the mechanism by which ethanol activates C1q remains poorly understood. Secretory IgM (sIgM), traditionally considered to act as an anti-microbial, also has critical housekeeping ...
- PubMed Central: