Jump to Main Content
- Kim, Lark Kyun, et al. Show all 5 Authors
- Biochemical and biophysical research communications 2017
- Escherichia coli; acidification; antibacterial properties; bacteria; bacterial infections; cytokines; lectins; macrophages; mice; pathogenesis; peritonitis; phagocytosis; phagosomes; sepsis (infection); survival rate
- ... Sepsis is a life-threatening condition caused by an uncontrolled response to bacterial infection. Impaired bactericidal activity in the host is directly associated with severe sepsis; however, the underlying regulatory mechanism(s) is largely unknown. Here, we show that MCL (macrophage C-type lectin) plays a crucial role in killing bacteria during Escherichia coli-induced peritonitis. MCL-deficien ...
- Kim, Lark Kyun, et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.22 pp. E2891
- allergens; asthma; chitin; chitinase; dust; dust mites; enzyme activity; exoskeleton; hypersensitivity; immune response; mice; people; polymers
- ... Chitinases are enzymes that cleave chitin, a component of the exoskeleton of many organisms including the house dust mite (HDM). Here we show that knockin mice expressing an enzymatically inactive acidic mammalian chitinase (AMCase), the dominant true chitinase in mouse lung, showed enhanced type 2 immune responses to inhaled HDM. We found that uncleaved chitin promoted the release of IL-33, where ...
- PubMed Central: