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- Capel, Blanche, et al. Show all 13 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.52 pp. 22323-22328
- Sertoli cells; cell proliferation; chromatin; gene dosage; gene expression regulation; gene targeting; genetic background; germ cells; humans; males; mice; mitosis; mutants; neoplasms; precipitin tests; testicular development; transcription factors; tumor suppressor genes
- ... Dmrt1 (doublesex and mab-3 related transcription factor 1) is a conserved transcriptional regulator of male differentiation required for testicular development in vertebrates. Here, we show that in mice of the 129Sv strain, loss of Dmrt1 causes a high incidence of teratomas, whereas these tumors do not form in Dmrt1 mutant C57BL/6J mice. Conditional gene targeting indicates that Dmrt1 is required ...
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