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- Wang, Man; Dubiak, Kyle; Zhang, Zhenbin; Huber, Paul W.; Chen, David D.Y.; Dovichi, Norman J.
- Talanta 2019 v.204 pp. 138-144
- programmed cell death, etc ; Xenopus laevis; algorithms; cell communication; cell membranes; ceramides; digestive system; embryogenesis; ions; mass spectrometry; metabolites; models; phosphatidylcholines; protein synthesis; vertebrates; Show all 15 Subjects
- ... Xenopus laevis is an important model organism for vertebrate development. An extensive literature has developed on changes in transcript expression during development of this organism, and there is a growing literature on the corresponding protein expression changes during development. In contrast, there is very little information on changes in metabolite expression during development. We present ...
- Russo, Arianna; Gatti, Guido; Alfieri, Roberta; Pesce, Elisa; Soanes, Kelly; Ricciardi, Sara; Mancino, Marilena; Cheroni, Cristina; Vaccari, Thomas; Biffo, Stefano; Calamita, Piera
- Developmental biology 2019 v.455 no.1 pp. 100-111
- programmed cell death, etc ; Drosophila melanogaster; biochemical pathways; biogenesis; biosynthesis; cell proliferation; ecdysone; genes; mammals; models; phenotype; protein synthesis; ribosomes; signal transduction; transcription factors; yeasts; Show all 16 Subjects
- ... During development, ribosome biogenesis and translation reach peak activities, due to impetuous cell proliferation. Current models predict that protein synthesis elevation is controlled by transcription factors and signalling pathways. Developmental models addressing translation factors overexpression effects are lacking. Eukaryotic Initiation Factor 6 (eIF6) is necessary for ribosome biogenesis a ...
- Ma, Yuanhui; McClatchy, Daniel B.; Barkallah, Salim; Wood, William W.; Yates, John R.
- Journal of Proteome Research 2017 v.16 no.6 pp. 2213-2220
- programmed cell death, etc ; cell lines; models; neurodegenerative diseases; protein synthesis; proteins; proteome; Show all 7 Subjects
- ... Here we describe a new strategy, HILAQ (Heavy Isotope Labeled Azidohomoalanine Quantification), to rapidly quantify the molecular vulnerability profile to oxytosis, which is an oxidative stress-induced programed cell death pathway that has been reported to be involved in aging and neurodegenerative diseases. HILAQ was able to quantify 1962 newly synthesized proteins (NSPs) after 1 h of pulse label ...
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