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- Brass, David M., et al. Show all 9 Authors
- Journal of Proteome Research 2017 v.16 no.2 pp. 538-549
- bronchiolitis; cilia; crosslinking; diacetyl; epithelial cells; epithelium; fibrosis; fluorescent antibody technique; humans; keratin; models; monitoring; pathogenesis; phosphopeptides; phosphorylation; proteome; proteomics; rodents; staining; toxicity; vapors
- ... Occupational exposures to the diketone flavoring agent, diacetyl, have been associated with bronchiolitis obliterans, a rare condition of airway fibrosis. Model studies in rodents have suggested that the airway epithelium is a major site of diacetyl toxicity, but the effects of diacetyl exposure upon the human airway epithelium are poorly characterized. Here we performed quantitative LC–MS/MS-base ...