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- Smider, Vaughn V., et al. Show all 10 Authors
- Chemical communications 2017 v.53 no.30 pp. 4234-4237
- cell growth; chemical compounds; chemical reactions; cytotoxins; drugs; integrins; mutants; neoplasm cells
- ... Cell-targeting conjugates of Saporin 6, a ribosome inactivating protein (RIP), were prepared using the Saporin Ala 157 Cys mutant, a small molecule inhibitor (SMI) of integrins αᵥβ₃/αᵥβ₅, and a potent cytotoxin, auristatin F (AF). The conjugates selectively and potently inhibited proliferation of tumor cells expressing the target integrins. We anticipate that the small molecule–RIP bioconjugate ap ...