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You searched for: Author "Ranganathan, Rama" Remove constraint Author: "Ranganathan, Rama" Subject mutation Remove constraint Subject: mutation
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1. Origins of Allostery and Evolvability in Proteins: A Case Study

Author:
Ranganathan, Rama,   et al.   ; Raman, Arjun S.; White, K. Ian;     Show all 3 Authors
Source:
Cell 2016 v.166 pp. 468-480
ISSN:
0092-8674
Subject:
active sites; amino acids; case studies; evolutionary adaptation; ligands; mutation; phenotype; proteins
Abstract:
... Proteins display the capacity for adaptation to new functions, a property critical for evolvability. But what structural principles underlie the capacity for adaptation? Here, we show that adaptation to a physiologically distinct class of ligand specificity in a PSD95, DLG1, ZO-1 (PDZ) domain preferentially occurs through class-bridging intermediate mutations located distant from the ligand-bindin ...
DOI:
10.1016/j.cell.2016.05.047

2. Evolvability as a Function of Purifying Selection in TEM-1 β-Lactamase

Author:
Ranganathan, Rama,   et al.   ; Stiffler, Michael A.; Hekstra, Doeke R.;     Show all 3 Authors
Source:
Cell 2015 v.160 pp. 882-892
ISSN:
0092-8674
Subject:
ampicillin; beta-lactamase; cefotaxime; environmental factors; enzyme activity; mutation
Abstract:
... Evolvability—the capacity to generate beneficial heritable variation—is a central property of biological systems. However, its origins and modulation by environmental factors have not been examined systematically. Here, we analyze the fitness effects of all single mutations in TEM-1 β-lactamase (4,997 variants) under selection for the wild-type function (ampicillin resistance) and for a new functi ...
DOI:
10.1016/j.cell.2015.01.035

3. Elevated Basal Slippage Mutation Rates among the Canidae

Author:
Ranganathan, Rama,   et al.   ; Laidlaw, Jeffrey; Gelfand, Yevgeniy; Ng, Kar-Wai; Garner, Harold R.; Benson, Gary; Fondon, John W. III.;     Show all 7 Authors
Source:
Journal of heredity 2007 v.98 no.5 pp. 452-460
ISSN:
0022-1503
Subject:
Canidae; carnivores; dogs; genes; humans; mutation; rodents; tandem repeat sequences
Abstract:
... The remarkable responsiveness of dog morphology to selection is a testament to the mutability of mammals. The genetic sources of this morphological variation are largely unknown, but some portion is due to tandem repeat length variation in genes involved in development. Previous analysis of tandem repeats in coding regions of developmental genes revealed fewer interruptions in repeat sequences in ...
DOI:
10.1093/jhered/esm017
PubMed:
17437958