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- Lybaert, Lien, et al. Show all 4 Authors
- Journal of controlled release 2018 v.289 pp. 125-145
- T-lymphocytes; cancer vaccines; cytotoxicity; disease course; immune response; nanoparticles; neoplasms; patients; probability; vaccination
- ... During the last decade anti-tumor immune-therapy has opened novel opportunities to efficiently combat cancer progression. The introduction of DC- and CAR T-cell based therapies as well as the successful application of antibody-based inhibitor of immune checkpoints (CTLA-4, PD1 and PDL1) have boosted the field and led to an overall benefit for many patients. In situ cancer vaccination is an attract ...
- Lybaert, Lien, et al. Show all 7 Authors
- Biomacromolecules 2016 v.17 no.3 pp. 874-881
- CD8-positive T-lymphocytes; antigens; composite polymers; dendritic cells; immunotherapy; lysine; models; neoplasms; ovalbumin; polymerization; thiols; vaccines
- ... Although the field of cancer immunotherapy is intensively investigated, there is still a need for generic strategies that allow easy, mild and efficient formulation of vaccine antigens. Here we report on a generic polymer–protein ligation strategy to formulate protein antigens into reversible polymeric conjugates for enhanced uptake by dendritic cells and presentation to CD8 T-cells. A N-hydroxypr ...