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You searched for: Subject term neuroprotective effect Remove constraint Subject term: neuroprotective effect Subject term fruits Remove constraint Subject term: fruits Subject term Cornus officinalis Remove constraint Subject term: Cornus officinalis
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1. The novel protective effects of loganin against 1‐methyl‐4‐phenylpyridinium‐induced neurotoxicity: Enhancement of neurotrophic signaling, activation of IGF‐1R/GLP‐1R, and inhibition of RhoA/ROCK pathway

Author:
Yu‐Ting Tseng; Wan‐Jung Lin; Wan‐Hsuan Chang; Yi‐Ching Lo
Source:
Phytotherapy research 2019 v.33 no.3 pp. 690-701
ISSN:
0951-418X
Subject:
Cornus officinalis; Parkinson disease; antagonists; apoptosis; cytotoxicity; fruits; glucagon-like peptide receptors; insulin-like growth factor I receptor; loganin; models; neurites; neuroprotective effect; neurotoxicity; osteoporosis; oxidative stress; reactive oxygen species; tyrosine 3-monooxygenase
Abstract:
... Loganin, a major iridoid glycoside obtained from fruits of Cornus officinalis, possesses anti‐inflammatory, antitumor, antidiabetic, and osteoporosis prevention effects. Loganin has been linked to neuroprotection in several models of neurodegeneration, including Parkinson's disease (PD). However, mechanisms underlying the neuroprotective effects of loganin are still mostly unknown. Here, we demons ...
DOI:
10.1002/ptr.6259

2. Iridoid glycosides from the fruits of Cornus officinalis

Author:
Xin Wang; Chong-Hui Liu; Jin-Jie Li; Bo Zhang; Lin-Lin Ji; Xiao-Ya Shang
Source:
Journal of Asian natural products research 2018 v.20 no.10 pp. 934-942
ISSN:
1477-2213
Subject:
Cornus officinalis; ethanol; fruits; iridoid glycosides; neuroprotective effect; nuclear magnetic resonance spectroscopy; spectral analysis
Abstract:
... Four new iridoid glycosides named cornusphenosides A–D (1–4) were isolated from an ethanol extract of the fruits of Cornus officinalis (shan zhu yu). The structures of these compounds were elucidated on the basis of spectroscopic data (UV, IR, HRESIMS, and 1D and 2D NMR) and chemical evidence. The neuroprotective effects of compounds 1–4 were also assessed in vitro. ...
DOI:
10.1080/10286020.2018.1497609

3. Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc

Author:
Jun Huang; Yiwei Zhang; Lin Dong; Qinghan Gao; Lei Yin; Hongfeng Quan; Rong Chen; Xueyan Fu; Dingbo Lin
Source:
Journal of ethnopharmacology 2017 pp. -
ISSN:
0378-8741
Subject:
Cornus officinalis; Internet; Oriental traditional medicine; analgesic effect; analytical methods; anti-aging properties; antineoplastic activity; cardioprotective effect; chemical composition; chemical constituents of plants; drugs; fruits; glycemic effect; herbs; hypertension; immunomodulation; kidneys; knees; loganin; neuroprotective effect; organic acids and salts; pain; quality control; renoprotective effect; therapeutics; toxicology; waist; China
Abstract:
... Cornus officinalis (Cornaceae), known in Chinese as “Shanzhuyu,” is a frequently used traditional Chinese medicine. It tastes sour and is astringent and slightly warm in nature. Its fruits have long been used to treat kidney deficiency, high blood pressure, waist and knee pain, dizziness, tinnitus, impotence, spermatorrhea, menorrhagia, and other diseases in China. The main distribution areas are ...
DOI:
10.1016/j.jep.2017.11.010

4. Neuroprotective iridoid glycosides from Cornus officinalis fruits against glutamate-induced toxicity in HT22 hippocampal cells

Author:
Eun Ju Jeong; Tae Bum Kim; Heejung Yang; So Young Kang; Sun Yeou Kim; Sang Hyun Sung; Young Choong Kim
Source:
Phytomedicine 2012 v.19 no.3-4 pp. 317-321
ISSN:
0944-7113
Subject:
Cornus officinalis; fruits; hydrolysis; loganin; neuroprotective effect; toxicity
Abstract:
... The methanolic extract of the fruits of Cornus officinalis S et Z. (Cornaceae) showed the significant neuroprotective activity against glutamate-induced toxicity in HT22 hippocampal cells. Chemical profile of n-BuOH fraction of the methanolic extract of C. officinalis fruits, which showed the most potent activity, was established using HPLC-diode array detector-electrospray-MS (HPLC-DAD-ESI-MS). T ...
DOI:
10.1016/j.phymed.2011.08.068