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1. Essentiality of zinc in human nutrition

Author:
Sandstead, Harold H.; Penland, James G.; Alcock, Nancy W.
Source:
Zinc : report of an international meeting : 12-13 September 1996, Adelaide / edited by Andrew Langley and Sam Mangas pp. -
Subject:
dietary minerals; zinc; nutrient deficiencies; growth retardation; enzyme activity; nucleic acids; insulin-like growth factor binding proteins; tissue repair; brain; nutritional status; neuroprotective effect; child nutrition; children; rural areas; elementary students; nutrient requirements; psychology; blood serum; nutrient availability; hairs; China
Handle:
10113/47044

2. Chongmyungtang attenuates kainic acid-induced seizure and mortal effect in the mouse

Author:
Kyung-Jin Jang; Kyou-Heung Lee; Sang-Lin Kim; Dong-Young Choi; Beom-Kyu Park; Doo-Hyun Im; Yong-Joon Cho; Wang-Kee Jhoo; Hyoung-Chun Kim
Source:
Archives of pharmacal research 1997 v.20 no.4 pp. 375-378
ISSN:
0253-6269
Subject:
Polygala tenuifolia; antigens; hippocampus; humans; mice; mortality; nervous system diseases; neuroprotective effect; seizures
Abstract:
... TheChongmyungtang (CMT; the combination ofAcorus gramineus, polygala tenuifolia andPoria cocos) has been recognized to possess the preventive effect against several neurologic disorders in human. In this study, we examined the effect of CMT on the three parameters associated with kainic acid (KA)-induced neurotoxicities; seizure/mortality, increased fos-related antigen (FRA) and glial fibrillary a ...
DOI:
10.1007/BF02976204

3. Ultratrace elements in nutrition: current knowledge and speculation

Author:
Nielsen, Forrest H.
Source:
Journal of trace elements in experimental medicine 1998 v.11 no.2-3 pp. 251-274
ISSN:
1520-670X
Subject:
dietary minerals; trace elements; mineral metabolism; energy metabolism; health promotion; immunity; neuroprotective effect; brain; insulin secretion; glucose tolerance; lipolysis; glycemic effect; nutrition knowledge
Abstract:
... The term ultratrace element has been defined as an element with an established, estimated, or suspected requirement generally indicated by μg/day for humans. Between 1970 and 1984, it was suggested that 11 elements should be added to the list of ultratrace elements that included chromium, molybdenum, and selenium; these elements were arsenic, boron, bromine, cadmium, fluorine, lead, lithium, nicke ...
Handle:
10113/45755
DOI:
10.1002/(SICI)1520-670X(1998)11:2/3<251::AID-JTRA15>3.0.CO;2-Q

4. Different mechanisms of protection against apoptosis by valproate and Li⁺

Author:
Alfonso Mora; Rosa A. González‐Polo; José M. Fuentes; Germán Soler; Francisco Centeno
Source:
European journal of biochemistry 1999 v.266 no.3 pp. 886-891
ISSN:
0014-2956
Subject:
apoptosis; branched chain fatty acids; glutamic acid; insulin; lithium; neuroprotective effect; phosphatidylinositol 3-kinase; plasma membrane; potassium
Abstract:
... Acute treatment with valproate and Li⁺ was found to protect cultured cerebellar granule cells against apoptosis induced by low K⁺ (5 mm). Because the protection was unaffected by MK801 (N‐methyl‐d‐aspartate receptor inhibitor), an increase in glutamate release cannot be responsible for the observed neuroprotection. Insulin also protects against low‐K⁺‐induced apoptosis of cerebellar granule cells. ...
DOI:
10.1046/j.1432-1327.1999.00919.x

5. Estrogen induces a rapid secretion of amyloid β precursor protein via the mitogen‐activated protein kinase pathway

Author:
Dieter Manthey; Stefanie Heck; Stefanie Engert; Christian Behl
Source:
European journal of biochemistry 2001 v.268 no.15 pp. 4285-4291
ISSN:
0014-2956
Subject:
Alzheimer disease; amyloid; brain; estradiol; estrogen receptors; females; humans; mice; mitogen-activated protein kinase; mitogen-activated protein kinase kinase kinase; neurons; neuroprotective effect; pathogenesis; phosphorylation; secretion
Abstract:
... The female sex hormone estrogen (17β‐estradiol; E2) may function as a neurohormone and has multiple neuromodulatory functions in the brain. Its potent neuroprotective activities can be dependent and independent of estrogen receptors (ERs). In addition, E2 influences the processing of the amyloid β precursor protein (APP), one central step in the pathogenesis of Alzheimer's disease. Here, we sh ...
DOI:
10.1046/j.1432-1327.2001.02346.x

6. Neuroprotective Effects of Withania somnifera Dunn. in Hippocampal Sub-regions of Female Albino Rat

Author:
Jain, Sushma; Shukla, Sunil Dutt; Sharma, Kanika; Bhatnagar, Maheep
Source:
Phytotherapy research 2001 v.15 no.6 pp. 544-548
ISSN:
0951-418X
Subject:
Withania somnifera; albino; brain; neuroprotective effect; powders; rats; roots; India
Abstract:
... The neuroprotective effects of W. somnifera were studied on stressed adult female Swiss albino rats. Experimental rats were subjected to immobilization stress for 14 h and were treated with a root powder extract of W. somnifera available as Stresscom capsules (Dabur India Ltd). Control rats were maintained in completely, non stressed conditions. Thionin stained serial coronal sections (7 μm) of br ...
DOI:
10.1002/ptr.802
PubMed:
11536389

7. Qualitative versus quantitative caloric intake: are they equivalent paths to successful aging?

Author:
Casadesus, Gemma; Shukitt-Hale, Barbara; Joseph, James A.
Source:
Neurobiology of aging 2002 v.23 no.5 pp. 747-769
ISSN:
1558-1497
Subject:
neuroprotective effect; Alzheimer disease; human diseases; neurophysiology; neurons; oxidative stress; phytochemicals; brain; antioxidant activity; dietary supplements; Parkinson disease; antioxidants; low calorie diet
Abstract:
... With the increasing demands placed on our society to perform better for longer, in addition to the large increase in the old segment of our population, a race has begun to forestall or reverse the ubiquitous declines that emerge from growing old. Currently, little is known about the mechanisms responsible for the neuronal degeneration seen during both normal aging and neurodegenerative disease; ho ...
Handle:
10113/22242
DOI:
10.1016/S0197-4580(02)00079-9
PubMed:
12392779

8. Dietary Manganese Intake and Type of Lipid Do Not Affect Clinical or Neuropsychological Measures in Healthy Young Women

Author:
Finley, John W.; Penland, James G.; Pettit, Ross E.; Davis, Cindy D.
Source:
Journal of nutrition 2003 v.133 no.9 pp. 2849-2856
ISSN:
0022-3166
Subject:
manganese; neuroprotective effect; neurophysiology; cocoa butter; mineral metabolism; dietary fat; women; nutrient excess; nutrient deficiencies; dietary energy sources; young adults; psychology; intestinal absorption; dietary nutrient sources; lipolysis; corn oil; toxicity; dietary minerals; dietary mineral supplements
Abstract:
... Because manganese (Mn) is potentially toxic, and because dietary fat type may affect Mn absorption, the objectives of the current study were to determine whether diets containing very low or very high amounts of Mn and enriched in either saturated or unsaturated fats affected measures of neuropsychological and basic metabolic function. Healthy young women were fed for 8 wk each, in a crossover des ...
Handle:
10113/46933
PubMed:
12949376

9. Effect of Piper betle Leaf Extract on Alcoholic Toxicity in the Rat Brain

Author:
Saravanan, R.; Rajendra Prasad, N.; Pugalendi, K.V.
Source:
Journal of medicinal food 2003 v.6 no.3 pp. 261-265
ISSN:
1096-620X
Subject:
neuroprotective effect; leaf extracts; glutathione; catalase; free fatty acids; brain; Piper betle; lipid peroxidation; superoxide dismutase; vitamin E; cholesterol; glutathione peroxidase; toxicity; rats; phospholipids; hydroperoxides; thiobarbituric acid-reactive substances; ascorbic acid
Abstract:
... The protective effect of Piper betle, a commonly used masticatory, has been examined in the brain of ethanol-administered Wistar rats. Brain of ethanol-treated rats exhibited increased levels of lipids, lipid peroxidation, and disturbances in antioxidant defense. Subsequent to the experimental induction of toxicity (i.e., the initial period of 30 days), aqueous P. betle extract was simultaneously ...
DOI:
10.1089/10966200360716689
PubMed:
14585193

10. Honokiol ameliorates cerebral infarction from ischemia-reperfusion injury in rats

Author:
Liou, K.T.; Lin, S.M.; Huang, S.S.; Chih, C.L.; Tsai, S.K.
Source:
Planta medica 2003 v.69 no.2 pp. 130-134
ISSN:
0032-0943
Subject:
Magnolia; herbs; medicinal plants; plant extracts; chemical constituents of plants; biphenyl; antioxidants; free radicals; stroke; disease control; hemodynamics; dose response; animal models; rats; resveratrol; chemical structure; neuroprotective effect
DOI:
10.1055/s-2003-37707
PubMed:
12624817

11. Ixeris dentata extract maintains glutathione concentrations in mouse brain tissue under oxidative stress induced by kainic acid

Author:
Oh, Sang Hee; Sung, Tae Hwa; Kim, Mee Ree
Source:
Journal of medicinal food 2003 v.6 no.4 pp. 353-358
ISSN:
1096-620X
Subject:
brain; glutathione; glutathione peroxidase; glutathione-disulfide reductase; methanol; mice; neuroprotective effect; neurotoxicity; oxidative stress
Abstract:
... The neuroprotective effects of a water fraction from the methanol extract of Ixeris dentata (WFID) against oxidative stress in the brain of mice challenged with kainic acid were examined by evaluating behavioral characteristics and biochemical parameters of oxidative stress. Male ICR mice were divided into three groups: a control group that received no treatment and two groups challenged with kain ...
DOI:
10.1089/109662003772519912
PubMed:
14977444

12. Neuroprotective Activity of p-Terphenyl Leucomentins from the Mushroom Paxillus panuoides

Author:
In-Kyoung LEE; Bong-Sik YUN; Jong-Pyung KIM; In-Ja RYOO; Young-Ho KIM; Ick-Dong YOO
Source:
Bioscience, biotechnology, and biochemistry 2003 v.67 no.8 pp. 1813-1816
ISSN:
1347-6947
Subject:
DNA; Paxillus; biotechnology; iron; lipid peroxidation; mushrooms; neuroprotective effect; neurotoxicity
Abstract:
... The neuroprotective mechanism of p-terphenyl leucomentins from the mushroom Paxillus panuoides was studied. Leucomentins showed potent inhibition of lipid peroxidation and H₂O₂ neurotoxicity, but free from any role as reactive oxygen species (ROS) scavengers. Iron-mediated oxidative damage has been implicated in these processes, as a provider of ROS via iron. Leucomentins can chelate iron when DNA ...
DOI:
10.1271/bbb.67.1813

13. Neuroprotective Effect of Rough Aster Butanol Fraction against Oxidative Stress in the Brain of Mice Challenged with Kainic Acid

Author:
Sok, Dai-Eun; Oh, Sang Hee; Kim, Yun-Bae; Kim, Mee Ree
Source:
Journal of agricultural and food chemistry 2003 v.51 no.16 pp. 4570–4575
ISSN:
0021-8561
Subject:
Aster scaber; brain; brain damage; butanol; glutathione peroxidase; glutathione-disulfide reductase; methanol; mice; neuroprotective effect; oxidative stress; thiobarbituric acid-reactive substances
Abstract:
... The neuroprotective effect of the butanol fraction from the methanol extract of Aster scaber Thunb. (rough aster butanol fraction) on oxidative damage in the brain of mice challenged with kainic acid was examined using behavioral signs and biochemical parameters of oxidative stress. The rough aster butanol fraction (0.4−1.0 g/kg) was administered to ICR male mice, 6−8 weeks, through a gavage for 4 ...
DOI:
10.1021/jf034251d

14. p-Terphenyl curtisians protect cultured neuronal cells against glutamate neurotoxicity via iron chelation

Author:
Lee, I.K.; Yun, B.S.; Kim, J.P.; Kim, W.G.; Ryoo, I.J.; Oh, S.; Kim, Y.H.; Yoo, I.D.
Source:
Planta medica 2003 v.69 no.6 pp. 513-517
ISSN:
0032-0943
Subject:
DNA damage; lipid peroxidation; glutamates; signal transduction; oxidative stress; glutathione; iron; neurotoxins; cerebral cortex; mushrooms; chemoreceptors; neurotoxicity; neurons; chelating agents; phytochemicals; antagonists; mice; fruiting bodies; antioxidants; chemical structure; phenylacetic acid; neuroprotective effect; Paxillus; cultured cells; South Korea
DOI:
10.1055/s-2003-40650
PubMed:
12865968

15. Aristolactam BII of Saururus chinensis attenuates glutamate-induced neurotoxicity in rat cortical cultures probably by inhibiting nitric oxide production

Author:
Kim, S.R.; Sung, S.H.; Kang, S.Y.; Koo, K.A.; Kim, S.H.; Ma, C.J.; Lee, H.S.; Park, M.J.; Kim, Y.C.
Source:
Planta medica 2004 v.70 no.5 pp. 391-396
ISSN:
0032-0943
Subject:
neuroprotective effect; neurotoxicity; peroxides; alkaloids; neurons; nitric oxide; phytochemicals; biosynthesis; glutamates; plant extracts; medicinal plants; Saururus; cerebral cortex; signal transduction; cultured cells; rats; lactams; nitrites; adverse effects
DOI:
10.1055/s-2004-818964
PubMed:
15124081

16. Attenuating effect of a traditional Korean formulation, Paeng-Jo-Yeon-Nyeon-Baek-Ja-In-Hwan (PJBH), on hydrogen peroxide-induced injury in PC12 cells

Author:
Koo, B.S.; Kim, Y.K.; Park, K.S.; Chung, K.H.; Kim, C.H.
Source:
Phytotherapy research 2004 v.18 no.6 pp. 488-493
ISSN:
0951-418X
Subject:
Oriental traditional medicine; medicinal plants; neuroprotective effect; South Korea
DOI:
10.1002/ptr.1457
PubMed:
15287076

17. Cellular pathology of Parkinson’s disease: astrocytes, microglia and inflammation

Author:
Peter Teismann; Jörg B. Schulz
Source:
Cell and tissue research 2004 v.318 no.1 pp. 149-161
ISSN:
0302-766X
Subject:
Parkinson disease; astrocytes; cytokines; ganglia; glutamic acid; inflammation; neurons; neuroprotective effect; pathogenesis; prostaglandins; reactive oxygen species
Abstract:
... Parkinson’s disease (PD) is a frequent neurological disorder of the basal ganglia, which is characterized by the progressive loss of dopaminergic neurons mainly in the substantia nigra pars compacta (SNpc). Inflammatory processes have been shown to be associated with the pathogenesis of PD. Activated microglia, as well as to a lesser extent reactive astrocytes, are found in the area associated wit ...
DOI:
10.1007/s00441-004-0944-0

18. Characteristics of taurine release induced by free radicals in mouse hippocampal slices

Author:
P. Saransaari; S. S. Oja
Source:
Amino acids 2004 v.26 no.1 pp. 91-98
ISSN:
0939-4451
Subject:
adenosine; adults; agonists; antagonists; cell membranes; glutamic acid; hippocampus; hydrogen peroxide; hydroxylamine; ischemia; mice; neuroprotective effect; nitric oxide; receptors; taurine; transporters; tritium
Abstract:
... The release of the inhibitory neuromodulator taurine in the hippocampus is markedly enhanced under various neural cell-damaging conditions, including ischemia and exposure to free radicals. The properties and regulation of the release evoked by a medium containing free radicals was investigated in hippocampal slices from adult (3-month-old) and developing (7-day-old) mice, using a superfusion syst ...
DOI:
10.1007/s00726-003-0004-1

19. Deep brain stimulation

Author:
Sorin Breit; Jörg B. Schulz; Alim-Louis Benabid
Source:
Cell and tissue research 2004 v.318 no.1 pp. 275-288
ISSN:
0302-766X
Subject:
L-dopa; Parkinson disease; brain; disease course; electrodes; electrophysiology; ganglia; ion channels; morbidity; neurons; neuroprotective effect; neurotransmitters; pathophysiology; patients; quality of life; therapeutics
Abstract:
... During the last decade deep brain stimulation (DBS) has become a routine method for the treatment of advanced Parkinson’s disease (PD), leading to striking improvements in motor function and quality of life of PD patients. It is associated with minimal morbidity. The rationale of targeting specific structures within basal ganglia such as the subthalamic nucleus (STN) or the internal segment of the ...
DOI:
10.1007/s00441-004-0936-0

20. Does diet protect against Parkinson's disease: Part 3 -- fruit, vegetables and grains

Author:
Brown, I.
Source:
Nutrition and food science 2004 v.34 no.5 pp. 194-197
ISSN:
0034-6659
Subject:
neuroprotective effect; eating habits; nutritional intervention; health promotion; food grains; vegetables; lifestyle; Parkinson disease
DOI:
10.1108/00346650410560352

21. Flavonoids and the brain: interactions at the blood-brain barrier and their physiological effects on the central nervous system

Author:
Youdim, K.A.; Shukitt-Hale, B.; Joseph, J.A.
Source:
Free radical biology & medicine 2004 v.37 no.11 pp. 1683-1693
ISSN:
1873-4596
Subject:
neuroprotective effect; isoflavones; brain; human health; blood-brain barrier; intestinal absorption; antioxidants; cognition; plant estrogens
Abstract:
... Over the past few years there has been an exponential growth in the number of reports describing the effects of nutritional modulation on aging and age-related diseases. Specific attention has been directed toward the beneficial effects afforded by dietary antioxidants, in particular those from fruit and vegetables, in ameliorating age-related deficits in brain performance. The rationale for study ...
Handle:
10113/11019
DOI:
10.1016/j.freeradbiomed.2004.08.002

22. Gossypin protects primary cultured rat cortical cells from oxidative stress- and β-amyloid-lnduced toxicity

Author:
Injae Yoon; Kwang Heun Lee; Jungsook Cho
Source:
Archives of pharmacal research 2004 v.27 no.4 pp. 454-459
ISSN:
0253-6269
Subject:
2,2-diphenyl-1-picrylhydrazyl; antioxidant activity; ascorbic acid; brain; free radical scavengers; glutathione; iron; lipid peroxidation; neuroprotective effect; neurotoxicity; oxidative stress; rats; xanthine; xanthine oxidase
Abstract:
... The present study investigated the effects of gossypin, 3,3′,4′,5,7,8-hexahydroxyflavone 8-glu-coside, on the toxicity induced by oxidative stress or β-amyloid (Aᵦ) in primary cultured rat cortical cells. The antioxidant properties of gossypin were also evaluated by cell-free assays. Gossypin was found to inhibit the oxidative neuronal damage induced by xanthine/xanthine oxidase or by a glutathion ...
DOI:
10.1007/BF02980089

23. Neuroprotective lignans from the bark of Machilus thunbergii

Author:
Ma, C.J.; Sung, S.H.; Kim, Y.C.
Source:
Planta medica 2004 v.70 no.1 pp. 79-80
ISSN:
0032-0943
Subject:
neuroprotective effect; plant extracts; medicinal plants; cerebral cortex; cultured cells; lignans; spectral analysis; Persea; rats; chemical structure
DOI:
10.1055/s-2004-815463
PubMed:
14765301

24. Neurotrophic effects of talaumidin, a neolignan from Aristolochia arcuata, in primary cultured rat cortical neurons

Author:
Zhai, H.; Nakatsukasa, M.; Mitsumoto, Y.; Fukuyama, Y.
Source:
Planta medica 2004 v.70 no.7 pp. 598-602
ISSN:
0032-0943
Subject:
neuroprotective effect; dendrites; cell growth; phytochemicals; plant extracts; medicinal plants; cerebral cortex; cultured cells; lignans; rats; Aristolochia; Brazil
DOI:
10.1055/s-2004-827179
PubMed:
15303251

25. Protective effects of quercetin and vitamin C against oxidative stress-induced neurodegeneration

Author:
Heo, H.J.; Lee, C.Y.
Source:
Journal of agricultural and food chemistry 2004 v.52 no.25 pp. 7514-7517
ISSN:
0021-8561
Subject:
neuroprotective effect; membrane permeability; Alzheimer disease; neurons; hydrogen peroxide; cell membranes; cell lines; quercetin; oxidative stress; ascorbic acid
Abstract:
... Clinical trials of several neurodegenerative diseases have increasingly targeted the evaluation of various antioxidants' effectiveness. The human diet contains several thousand phytochemicals, many of which have significant bioactivities. Vitamin C, a naturally occurring antioxidant, is known to reduce the risk of neurodegenerative disorders such as Alzheimer's disease. Quercetin, one of the major ...
DOI:
10.1021/jf049243r

26. Proteomics analysis of rat brain protein modulations by grape seed extract

Author:
Deshane, J.; Chaves, L.; Sarikonda, K.V.; Isbell, S.; Wilson, L.; Kirk, M.; Grubbs, C.; Barnes, S.; Meleth, S.; Kim, H.
Source:
Journal of agricultural and food chemistry 2004 v.52 no.26 pp. 7872-7883
ISSN:
0021-8561
Subject:
grape seed extract; polyphenols; dietary supplements; food intake; protein synthesis; animal proteins; brain; proteome; proteomics; neuroprotective effect; rats
Abstract:
... Dietary supplements such as grape seed extract (GSE) enriched in proanthocyanidins (PA) (oligomeric polyphenols) have been suggested to have multiple health benefits, due to antioxidant and other beneficial activities of the PA. However, a systematic analysis of the molecular basis of these benefits has not been demonstrated. Because the brain is vulnerable to age-related oxidative damage and othe ...
DOI:
10.1021/jf040407d

27. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers

Author:
Charles N. Serhan; Makoto Arita; Song Hong; Katherine Gotlinger
Source:
Lipids 2004 v.39 no.11 pp. 1125-1132
ISSN:
0024-4201
Subject:
anti-inflammatory activity; aspirin; docosahexaenoic acid; eicosapentaenoic acid; neuroprotective effect; tissues
Abstract:
... The molecular basis for the beneficial impact of essential omega-3 (n−3) FA remains of interest. Recently, we identified novel mediators generated from eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that displayed potent bioactions identified first in resolving inflammatory exudates and in tissues enriched with DHA. The trivial names resolvin (resolution phase interaction products) a ...
DOI:
10.1007/s11745-004-1339-7

28. A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia

Author:
Tang, W.B.; Gao, Y.H.; Chen, G.L.; Gao, H.; Dai, X.H.; Ye, J.X.; Chan, E.; Huang, M.; Zhou, S.F.
Source:
Journal of medicinal food 2005 v.8 no.1 pp. 53-58
ISSN:
1096-620X
Subject:
traditional medicine; neuroprotective effect; nutrient intake; product safety; polysaccharides; dose response; Ganoderma lucidum; nervous system diseases; dosage; psychotherapy; chronic diseases; patients; extracts; fungi; Asia
DOI:
10.1089/jmf.2005.8.53
PubMed:
15857210

29. Changes in retinal neuronal populations in the DBA/2J mouse

Author:
Jung-Il Moon; In-Beom Kim; Jae-Sung Gwon; Myoung-Hee Park; Tae-Hoon Kang; Eun-Jin Lim; Kyu-Ryong Choi; Myung-Hoon Chun
Source:
Cell and tissue research 2005 v.320 no.1 pp. 51-59
ISSN:
0302-766X
Subject:
calbindin; choline acetyltransferase; death; gamma-aminobutyric acid; ganglia; glaucoma; histopathology; mice; models; neurons; neuroprotective effect; nitric oxide; nitric oxide synthase; osteopontin; pathogenesis; population; protein kinase C; retina
Abstract:
... DBA/2J (D2) mice develop a form of progressive pigmentary glaucoma with increasing age. We have compared retinal cell populations of D2 mice with those in control C57BL/6J mice to provide information on retinal histopathology in the D2 mouse. The D2 mouse retina is characterized by a reduction in retinal thickness caused mainly by a thinning of the inner retinal layers. Immunocytochemical staining ...
DOI:
10.1007/s00441-004-1062-8

30. Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress

Author:
Shukitt-Hale, B.; Galli, R.L.; Meterko, V.; Carey, A.; Bielinski, D.F.; McGhie, T.; Joseph, J.A.
Source:
Age the journal of the American Aging Association 2005 v.27 no.1 pp. 49-57
Subject:
memory; neurophysiology; polyphenols; black currants; cranberries; fruit composition; dietary supplements; oxidative stress; second messengers; biomarkers; dietary nutrient sources; cognition; hippocampus; neurons; nutritional intervention; physical activity; boysenberries; rats; antioxidant activity; antioxidants; neuroprotective effect; chemical composition; cyanin; vegetable extracts; physical fitness; inflammation; fruit extracts; animal models; chemical constituents of plants; vegetables; blueberries
Abstract:
... Dietary supplementation with fruit or vegetable extracts can ameliorate age-related declines in measures of learning, memory, motor performance, and neuronal signal transduction in a rat model. To date, blueberries have proved most effective at improving measures of motor performance, spatial learning and memory, and neuronal functioning in old rats. In an effort to further characterize the bioact ...
Handle:
10113/10955
DOI:
10.1007/s11357-005-4004-9
PubMed:
23598603
PubMed Central:
PMC3456098

31. Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid

Author:
Kim, H.; Park, B.S.; Lee, K.G.; Choi, C.Y.; Jang, S.S.; Kim, Y.H.; Lee, S.E.
Source:
Journal of agricultural and food chemistry 2005 v.53 no.22 pp. 8537-8541
ISSN:
0021-8561
Subject:
naphthoquinones; flavonoids; phenylpropanoids; animal proteins; brain; oxidative stress; neuroprotective effect; Alzheimer disease
Abstract:
... beta-Amyloid (betaA)-induced oxidative toxicity on neuronal cells is a principal route in Alzheimer's disease (AD), and its toxicity occurs after fibril formation. Inhibitory or promoting effects of naturally occurring compounds on betaA fibril formation were evaluated. Among 214 tested compounds, curcuminoids, flavone type flavonoids, and naphthoquinones were shown to be potent inhibitors of beta ...
DOI:
10.1021/jf051985c

32. Four new neuroprotective dihydropyranocoumarins from Angelica gigas

Author:
Kang, S.Y.; Lee, K.Y.; Sung, S.H.; Kim, Y.C.
Source:
Journal of natural products 2005 v.68 no.1 pp. 56-59
ISSN:
0163-3864
Subject:
Angelica gigas; medicinal plants; plant extracts; phytochemicals; coumarins; neuroprotective effect; chemical structure; spectral analysis; stereochemistry; rats; cerebral cortex; cultured cells; lactate dehydrogenase; enzyme activity; South Korea
DOI:
10.1021/np049705v
PubMed:
15679317

33. Green tea extract and catechin ameliorate chronic fatigue-induced oxidative stress in mice

Author:
Singal, A.; Kaur, S.; Tirkey, N.; Chopra, K.
Source:
Journal of medicinal food 2005 v.8 no.1 pp. 47-52
ISSN:
1096-620X
Subject:
green tea; plant extracts; catechin; antioxidants; antioxidant activity; free radicals; mice; animal models; oxidative stress; chronic diseases; nervous system diseases; neuroprotective effect; lipid peroxidation; glutathione; pathophysiology; pathogenesis
DOI:
10.1089/jmf.2005.8.47
PubMed:
15857209

34. Neuroprotective and antioxidant activity of compounds from the aerial parts of Dioscorea opposita

Author:
Ma, C.; Wang, W.; Chen, Y.Y.; Liu, R.N.; Wang, R.F.; Du, L.J.
Source:
Journal of natural products 2005 v.68 no.8 pp. 1259-1261
ISSN:
0163-3864
Subject:
neuroprotective effect; Dioscorea oppositifolia; neurons; phenanthrenes; phytochemicals; medicinal plants; plant extracts; cultured cells; spectral analysis; antioxidant activity; chemical structure; stereochemistry; China
DOI:
10.1021/np050021c
PubMed:
16124773

35. Neuroprotective and free radical scavenging activities of phenolic compounds fromHovenia dulcis

Author:
Gao Li; Byung-Sun Min; Changji Zheng; Joongku Lee; Sei-Ryang Oh; Kyung-Seop Ahn; Hyeong-Kyu Lee
Source:
Archives of pharmacal research 2005 v.28 no.7 pp. 804-809
ISSN:
0253-6269
Subject:
ferulic acid; free radical scavengers; inhibitory concentration 50; mice; neuroprotective effect; neurotoxicity; superoxide anion; vanillic acid
Abstract:
... The EtOAc-soluble fraction from a methanolic extract ofHovenia dulcis Thunb. exhibited neuroprotective activity against glutamate-induced neurotoxicity in mouse hippocampal HT22 cells. The neuroprotective activity-guided isolation resulted in 8 phenolic compounds (1–8), such as vanillic acid (1), ferulic acid (2), 3,5-dihydroxystilbene (3), (+)-aromadendrin (4), methyl vanillate (5), (-)-catechin ...
DOI:
10.1007/BF02977346

36. Neuroprotective effects of butterbur and rough aster against kainic acid-induced oxidative stress in mice

Author:
Oh, S.H.; Sok, D.E.; Kim, M.R.
Source:
Journal of medicinal food 2005 v.8 no.2 pp. 169-176
ISSN:
1096-620X
Subject:
neurophysiology; reactive oxygen species; lipid peroxidation; cytosol; oxidative stress; glutathione; dose response; brain; Petasites japonicus; cultivars; neurotoxicity; mice; antioxidant activity; thiobarbituric acid-reactive substances; neuroprotective effect; vegetable extracts; glutathione-disulfide reductase; glutathione peroxidase; animal models; South Korea
DOI:
10.1089/jmf.2005.8.169
PubMed:
16117608

37. Neuroprotective flavonoids from Flemingia macrophylla

Author:
Shiao, Y.J.; Wang, C.N.; Wang, W.Y.; Lin, Y.L.
Source:
Planta medica 2005 v.71 no.9 pp. 835-840
ISSN:
0032-0943
Subject:
traditional medicine; neuroprotective effect; neurons; medicinal plants; cultured cells; spectral analysis; flavonoids; rats; Flemingia macrophylla; antioxidant activity; chemical structure; Taiwan
DOI:
10.1055/s-2005-871297
PubMed:
16206038

38. Protection by petaslignolide A, a major neuroprotective compound in the butanol extract of Petasites japonicus leaves, against oxidative damage in the brains of mice challenged with kainic acid

Author:
Cui, H.S.; Kim, M.R.; Sok, D.E.
Source:
Journal of agricultural and food chemistry 2005 v.53 no.22 pp. 8526-8532
ISSN:
0021-8561
Subject:
Petasites japonicus; leaves; lignans; plant extracts; butanol; neuroprotective effect; neurotoxicity; oxidative stress; brain; mice
Abstract:
... The neuroprotective effect of petaslignolide A (PA), a furfuran lignan isolated from butanol fraction of Petasites japonicus (Sieb. et Zucc.) Maxim. (Compositae) leaves, on the oxidative damage in the brain of mice challenged with kainic acid was examined using behavioral signs and biochemical parameters of oxidative stress. PA (40 mg/kg) was administered to ICR male mice through a gavage for 4 da ...
DOI:
10.1021/jf051595q

39. Reciprocal activity of ginsenosides in the production of proinflammatory repertoire, and their potential roles in neuroprotection in vitro

Author:
Joo, S.S.; Won, T.J.; Lee, D.I.
Source:
Planta medica 2005 v.71 no.5 pp. 476-481
ISSN:
0032-0943
Subject:
Panax pseudoginseng; plant extracts; phytochemicals; triterpenoids; chemical structure; inflammation; neuroprotective effect; interleukin-1; interleukin-6; tumor necrosis factors; nitric oxide; rats; cultured cells; nucleotide sequences
DOI:
10.1055/s-2005-864145

40. Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley rats

Author:
Bu, Y.; Jin, Z.H.; Park, S.Y.; Baek, S.; Rho, S.; Ha, N.; Park, S.K.; Kim, S.Y.; Kim, H.
Source:
Phytotherapy research 2005 v.19 no.2 pp. 167-169
ISSN:
0951-418X
Subject:
Eleutherococcus senticosus; stems; roots; bark; plant extracts; medicinal plants; Oriental traditional medicine; neuroprotective effect; arteries; ischemia; brain; rats
DOI:
10.1002/ptr.1649
PubMed:
15852490

41. Strawberry and its anthocyanins reduce oxidative stress-induced apoptosis in PC12 cells

Author:
Heo, H.J.; Lee, C.Y.
Source:
Journal of agricultural and food chemistry 2005 v.53 no.6 pp. 1984-1989
ISSN:
0021-8561
Subject:
strawberries; oranges; bananas; anthocyanins; antioxidant activity; oxidative stress; hydrogen peroxide; neuroprotective effect; apoptosis; neurons; cell lines; Alzheimer disease; humans; catechin; naringenin
Abstract:
... Because strawberries are known to contain higher concentrations of phytochemicals and have higher antioxidant capacity among common fruits, their neuroprotective activity was tested in vitro on PC12 cells treated with H2O2. Their protective effect and antioxidant capacity were also compared with those of banana and orange, which are the fresh fruits consumed at highest levels in the United States. ...
DOI:
10.1021/jf048616l

42. The beneficial effects of fruit polyphenols on brain aging

Author:
Lau, Francis C.; Shukitt-Hale, Barbara; Joseph, James A.
Source:
Neurobiology of aging 2005 v.26 no.1 pp. S128
ISSN:
1558-1497
Subject:
neuroprotective effect; polyphenols; neurophysiology; motor neurons; humans; reactive oxygen species; inflammation; signal transduction; hippocampus; nervous system diseases; cognition; blueberries; oxidative stress
Abstract:
... Brain aging is characterized by the continual concession to battle against insults accumulated over the years. One of the major insults is oxidative stress, which is the inability to balance and to defend against the cellular generation of reactive oxygen species (ROS). These ROS cause oxidative damage to nucleic acid, carbohydrate, protein, and lipids. Oxidative damage is particularly detrimental ...
Handle:
10113/22215
DOI:
10.1016/j.neurobiolaging.2005.08.007

43. The neuroprotection of puerarin against cerebral ischemia is associated with the prevention of apoptosis in rats

Author:
Xu, X.; Zhang, S.; Zhang, L.; Yan, W.; Zheng, X.
Source:
Planta medica 2005 v.71 no.7 pp. 585-591
ISSN:
0032-0943
Subject:
neuroprotective effect; ischemia; messenger RNA; isoflavones; Pueraria montana var. lobata; caspases; medicinal plants; plant extracts; nucleotide sequences; rats; enzyme activity; gene expression regulation; apoptosis; cerebrovascular disorders
DOI:
10.1055/s-2005-871261
PubMed:
16041641

44. The role of essential fatty acids in development

Author:
Heird, W.C.; Lapillonne, A.
Source:
Annual review of nutrition 2005 v.25 pp. 549-571
ISSN:
0199-9885
Subject:
neuroprotective effect; docosahexaenoic acid; dietary fat; health promotion; evoked potentials; human milk fat; arachidonic acid; milk composition; infant development; omega-3 fatty acids
DOI:
10.1146/annurev.nutr.24.012003.132254

45. cAMP-response element-binding protein and heat-shock protein 70 additively suppress polyglutamine-mediated toxicity in Drosophila

Author:
Iijima-Ando, K.; Wu, P.; Drier, E.A.; Iijima, K.; Yin, J.C.P.
Source:
Proceedings of the National Academy of Sciences of the United States of America 2005 v.102 no.29 pp. 10261-10266
ISSN:
0027-8424
Subject:
heat shock proteins; polypeptides; neurotoxicity; transcription factors; neuroprotective effect; glutamine; nervous system diseases; Drosophila melanogaster; mortality; animal disease models
Abstract:
... Gene-specific expansion of polyglutamine-encoding CAG repeats can cause neurodegenerative disorders, including Huntington's disease. It is believed that part of the pathological effect of the expanded protein is due to transcriptional dysregulation. Using Drosophila as a model, we show that cAMP-response element-binding protein (CREB) is involved in expanded polyglutamine-induced toxicity. A mutat ...
DOI:
10.1073/pnas.0503937102
PubMed:
16009936
PubMed Central:
PMC1177387

46. A new neuroprotective compound of Ligustrum japonicum leaves

Author:
Sung, S.H.; Kim, E.S.; Lee, K.Y.; Lee, M.K.; Kim, Y.C.
Source:
Planta medica 2006 v.72 no.1 pp. 62-64
ISSN:
0032-0943
Subject:
Ligustrum japonicum; secoiridoids; glycosides; phytochemicals; chemical structure; spectral analysis; neuroprotective effect; humans; cultured cells; neurotoxicity; South Korea
DOI:
10.1055/s-2005-873140
PubMed:
16450298

47. A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro

Author:
Zeng, X.H.; Zhang, S.M.; Zhang, L.; Zhang, K.P.; Zheng, X.X.
Source:
Planta medica 2006 v.72 no.15 pp. 1359-1365
ISSN:
0032-0943
Subject:
neuroprotective effect; ischemia; animal disease models; medicinal plants; Gastrodia elata; human health; glucosides; rats; benzyl alcohol; Oriental traditional medicine; phenolic compounds
DOI:
10.1055/s-2006-951709
PubMed:
17089323

48. Antioxidant and neuroprotective effects of hesperidin and its aglycone hesperetin

Author:
Jungsook Cho
Source:
Archives of pharmacal research 2006 v.29 no.8 pp. 699-706
ISSN:
0253-6269
Subject:
2,2-diphenyl-1-picrylhydrazyl; ascorbic acid; bioassays; brain; citrus fruits; cultured cells; free radical scavengers; glutamic acid; hesperetin; hesperidin; hydrogen peroxide; iron; ligands; lipid peroxidation; neurodegenerative diseases; neurons; neuroprotective effect; rats; toxicity; xanthine; xanthine oxidase
Abstract:
... The present study evaluated antioxidant and neuroprotective activities of hesperidin, a flavanone mainly isolated from citrus fruits, and its aglycone hesperetin using cell-free bioassay system and primary cultured rat cortical cells. Both hesperidin and hesperetin exhibited similar patterns of 1,1-diphenyl-2-picrylhydrazyl radical scavenging activities. While hesperidin was inactive, hesperetin w ...
DOI:
10.1007/BF02968255

49. Beneficial effects of berry fruit polyphenols on neuronal and behavioral aging

Author:
Lau, F.C.; Shukitt-Hale, B.; Joseph, J.A.
Source:
Journal of the science of food and agriculture 2006 v.86 no.14 pp. 2251-2255
ISSN:
0022-5142
Subject:
functional foods; neuroprotective effect; polyphenols; elderly; anti-inflammatory activity; Alzheimer disease; neurons; small fruits; cardiovascular diseases; inflammation; nutritive value; elderly nutrition; human behavior; plant-based foods; antioxidant activity; oxidative stress
Abstract:
... It is becoming increasingly clear that although there is a great deal of research being devoted to elucidating the molecular mechanisms involved in aging, practical information on how to forestall or reverse the deleterious effects of aging may be years away. Therefore, it may be beneficial to determine other methods to improve the quality of life in the aging population. A plethora of epidemiolog ...
Handle:
10113/10615
DOI:
10.1002/jsfa.2671

50. Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection

Author:
Galli, Rachel L.; Bielinski, Donna F.; Szprengiel, Aleksandra; Shukitt-Hale, Barbara; Joseph, James A.
Source:
Neurobiology of aging 2006 v.27 no.2 pp. 344-350
ISSN:
1558-1497
Subject:
neuroprotective effect; heat shock proteins; food intake; lipopolysaccharides; inflammation; hippocampus; rats; blueberries
Abstract:
... Dietary supplementation with antioxidant rich foods can decrease the level of oxidative stress in brain regions and can ameliorate age-related deficits in neuronal and behavioral functions. We examined whether short-term supplementation with blueberries might enhance the brain's ability to generate a heat shock protein 70 (HSP70) mediated neuroprotective response to stress. Hippocampal (HC) region ...
Handle:
10113/22243
DOI:
10.1016/j.neurobiolaging.2005.01.017
PubMed:
15869824