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- Yadikar, Hamad Ahmad, et al. Show all 9 Authors
- Journal of the American Chemical Society 2018 v.140 no.43 pp. 14314-14323
- epitopes; microtubules; neurodegenerative diseases; nucleotide aptamers; oligomerization; phosphorylation; protein aggregates; therapeutics
- ... Tau proteins are proteins that stabilize microtubules, but their hyperphosphorylation can result in the formation of protein aggregates and, over time, neurodegeneration. This phenomenon, termed tauopathy, is pathologically involved in several neurodegenerative disorders. DNA aptamers are single-stranded oligonucleotides capable of specific binding to target molecules. Using tau epitopes predispos ...