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You searched for: Author kristin Remove constraint Author: kristin Subject ovarian neoplasms Remove constraint Subject: ovarian neoplasms
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1. Development of a multiplexed giant magnetoresistive biosensor array prototype to quantify ovarian cancer biomarkers

Author:
Boylan, Kristin L.M.,   et al.   ; Klein, Todd; Wang, Wei; Yu, Lina; Wu, Kai; Vogel, Rachel Isaksson; Skubitz, Amy P.N.; Wang, Jian-Ping;     Show all 8 Authors
Source:
Biosensors & bioelectronics 2019 v.126 pp. 301-307
ISSN:
0956-5663
Subject:
animal ovaries; antigens; biomarkers; biosensors; detection limit; epididymis; human diseases; humans; interleukin-6; mobile telephones; ovarian neoplasms; prototypes; user interface
Abstract:
... In this work, we developed benchtop and handheld Giant Magnetoresistive (GMR) biosensing systems that serve as platforms for detecting a wide variety of protein biomarkers for human diseases. System development included spintronic and nanomagnetic materials, biomolecular chemistry, electronic circuitry, analog and digital signal processing, firmware programming, user interface programming on both ...
DOI:
10.1016/j.bios.2018.10.046

2. Novel auristatin E-based albumin-binding prodrugs with superior anticancer efficacy in vivo compared to the parent compound

Author:
Walter, Heidi-Kristin,   et al.   ; Pes, Lara; Koester, Stephan David; Magnusson, Johannes Pall; Chercheja, Serghei; Medda, Federico; Abu Ajaj, Khalid; Rognan, Didier; Daum, Steffen; Nollmann, Friederike Inga; Garcia Fernandez, Javier; Perez Galan, Patricia; Warnecke, Anna; Kratz, Felix;     Show all 14 Authors
Source:
Journal of controlled release 2019 v.296 pp. 81-92
ISSN:
0168-3659
Subject:
active ingredients; antineoplastic activity; antineoplastic agents; cytotoxicity; drug carriers; head; humans; hydrazides; hydrazones; lung neoplasms; melanoma; models; neck; ovarian neoplasms; pH; peptides; serum albumin; skin irritation; water solubility
Abstract:
... Auristatins are a class of highly cytotoxic tubulin-disrupting peptides, which have shown limited therapeutic effect as free agents in clinical trials.In our continuing effort to develop acid-sensitive albumin-binding anticancer drugs exploiting circulating serum albumin as the drug carrier, we investigated the highly toxic drug payload auristatin E to assess whether the corresponding albumin-bind ...
DOI:
10.1016/j.jconrel.2019.01.010

3. Serum biomarkers of habitual coffee consumption may provide insight into the mechanism underlying the association between coffee consumption and colorectal cancer

Author:
Guertin, Kristin A,   et al.   ; Loftfield, Erikka; Boca, Simina M; Sampson, Joshua N; Moore, Steven C; Xiao, Qian; Huang, Wen-Yi; Xiong, Xiaoqin; Freedman, Neal D; Cross, Amanda J; Sinha, Rashmi;     Show all 11 Authors
Source:
TheAmerican journal of clinical nutrition 2015 v.101 no.5 pp. 1000-1011
ISSN:
0002-9165
Subject:
biomarkers; blood serum; caffeine; case-control studies; colorectal neoplasms; correlation; food frequency questionnaires; gas chromatography-mass spectrometry; linear models; metabolism; metabolites; metabolomics; ovarian neoplasms; regression analysis; screening; tandem mass spectrometry; theophylline; trigonelline
Abstract:
... Background: Coffee intake may be inversely associated with colorectal cancer; however, previous studies have been inconsistent. Serum coffee metabolites are integrated exposure measures that may clarify associations with cancer and elucidate underlying mechanisms. Objectives: Our aims were 2-fold as follows: 1) to identify serum metabolites associated with coffee intake and 2) to examine these met ...
DOI:
10.3945/ajcn.114.096099
PubMed:
25762808
PubMed Central:
PMC4409687

4. Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis

Author:
Boylan, Kristin L.M.,   et al.   ; Andersen, John D.; Xue, Feifei S.; Anderson, Lorraine B.; Witthuhn, Bruce A.; Markowski, Todd W.; Higgins, LeeAnn; Skubitz, Amy P.N.;     Show all 8 Authors
Source:
Electrophoresis 2010 v.31 no.4 pp. 599-610
ISSN:
0173-0835
Subject:
Western blotting; animal ovaries; biomarkers; blood proteins; blood serum; carcinoma; death; electrophoresis; ovarian neoplasms; patients; proteomics; survival rate; women; United States
Abstract:
... Ovarian cancer is the fifth leading cause of cancer death for women in the US, yet survival rates are over 90% when it is diagnosed at an early stage, highlighting the need for biomarkers for early detection. To enhance the discovery of tumor-specific proteins that could represent novel serum biomarkers for ovarian cancer, we depleted serum of highly abundant proteins which can mask the detection ...
DOI:
10.1002/elps.200900441
PubMed:
20162585
PubMed Central:
PMC3520508