Jump to Main Content
- Chang, Jer-Wei, et al. Show all 9 Authors
- Food and chemical toxicology 2017 v.108 pp. 276-288
- acetylcysteine; alpha-linolenic acid; apoptosis; arachidonic acid; breast neoplasms; cell proliferation; cytochrome c; docosahexaenoic acid; eicosapentaenoic acid; gamma-linolenic acid; gene expression; growth inhibitors; linoleic acid; messenger RNA; mitochondria; neoplasm cells; omega-3 fatty acids; phosphatidylinositol 3-kinase; phosphorylation; protein synthesis; reactive oxygen species; signal transduction; toxicology
- ... Oxidative stress-induced growth inhibitor 1 (OSGIN1), a tumor suppressor, inhibits cell proliferation and induces cell death. N-6 and n-3 PUFAs protect against breast cancer, but the molecular mechanisms of this effect are not clear. We investigated the effect of n-6 and n-3 PUFAs on OSGIN1 expression and whether OSGIN1 is involved in PUFA-induced apoptosis in breast cancer cells. We used 100 μM o ...
- Chang, Jer-Wei, et al. Show all 8 Authors
- Nutrition and cancer 2015 v.67 no.5 pp. 771-782
- breast neoplasms; cell invasion; cell movement; docosahexaenoic acid; enzyme activity; epidermal growth factor; epidermal growth factor receptors; gelatinase B; humans; messenger RNA; metastasis; neoplasm cells; phosphorylation; protein synthesis; u-plasminogen activator
- ... Urokinase plasminogen activator (uPA) and matrix metalloproteinase 9 (MMP-9) play crucial roles in tumor metastasis. Despite the well-known anticancer role of docosa-hexaenoic acid (DHA), its specific effect on ErbB2-mediated breast cancer metastasis is not fully clarified. In this study, we investigated the effect of DHA on epidermal growth factor (EGF)-induced uPA and MMP-9 activity, expression ...