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- Loscher, Christine E., et al. Show all 6 Authors
- Biochemical and biophysical research communications 2013 v.440 pp. 163-167
- antigens; autoimmune diseases; humans; immune response; immunoglobulin E; myeloma; pathogens; patients; plasma cells; plasma membrane; protein transport; secretion
- ... The humoral immune system provides a crucial first defense against the invasion of microbial pathogens via the secretion of antigen specific immunoglobulins (Ig). The secretion of Ig is carried out by terminally differentiated B-lymphocytes called plasma cells. Despite the key role of plasma cells in the immune response, the mechanisms by which they constitutively traffic large volumes of Ig out o ...
- Langer, Christine, et al. Show all 17 Authors
- Cellular and molecular life sciences 2016 v.73 no.21 pp. 4141-4158
- Plasmodium falciparum; adults; antibodies; children; epitopes; erythrocytes; genetic engineering; humans; malaria; parasites; phagocytosis; phenotype; pregnant women; protein transport; surface antigens; surface proteins; vaccine development
- ... Antibodies to blood-stage antigens of Plasmodium falciparum play a pivotal role in human immunity to malaria. During parasite development, multiple proteins are trafficked from the intracellular parasite to the surface of P. falciparum-infected erythrocytes (IEs). However, the relative importance of different proteins as targets of acquired antibodies, and key pathways involved in trafficking majo ...
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- Ström, Anne-Christine, et al. Show all 2 Author
- Genome biology 2001 v.2 no.6 pp. 174
- Saccharomyces cerevisiae; cytoplasm; guanosine triphosphate; guanosinetriphosphatase; humans; hydrolysis; importins; nuclear membrane; protein transport; receptors; yeasts
- ... In recent years, our understanding of macromolecular transport processes across the nuclear envelope has grown dramatically, and a large number of soluble transport receptors mediating either nuclear import or nuclear export have been identified. Most of these receptors belong to one large family of proteins, all of which share homology with the protein import receptor importin β (also named karyo ...