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101. Effect of a normal protein diet on oxidative stress and organ damage in malnourished rats

Author:
Gourine, Hanane; Grar, Hadria; Dib, Wafaa; Mehedi, Nabila; Boualga, Ahmed; Saidi, Djamel; Kheroua, Omar
Source:
Frontiers in biology 2018 v.13 no.5 pp. 366-375
ISSN:
1674-7984
Subject:
rats,   etc   ; antioxidants; body weight; catalase; enzyme activity; histology; intestinal mucosa; kwashiorkor; liver; low protein diet; malondialdehyde; muscles; oxidants; oxidative stress; serum albumin; superoxide dismutase; villi;     Show all 17 Subjects
Abstract:
... BACKGROUND: We investigated the effects of three weeks of renutrition with a normal protein diet on oxidant/antioxidant status in malnourished rats using biochemistry and histology. METHODS: Eighteen young Wistar rats were divided into three groups: control group was fed on a normal protein diet; malnourished group was fed on low protein diet and renourished group was fed on low protein diet follo ...
DOI:
10.1007/s11515-018-1511-5

102. Protective effects of Gastrodia elata Blume on acetaminophen-induced liver and kidney toxicity in rats

Author:
Seok, Pu Reum; Kim, Jung Hoan; Kwon, Hye Ri; Heo, Jin Sun; Choi, Jong Ryeol; Shin, Jae-Ho
Source:
Food science and biotechnology 2018 v.27 no.5 pp. 1445-1454
ISSN:
1226-7708
Subject:
rats,   etc   ; Gastrodia elata; acetaminophen; antioxidants; beta-N-acetylhexosaminidase; cytokines; glutathione; kidneys; liver; malondialdehyde; necrosis; nephrotoxicity; oral administration; overdose; oxidative stress; protective effect; superoxide dismutase;     Show all 17 Subjects
Abstract:
... An overdose of acetaminophen (AAP) causes hepatic and renal toxicity. This study examined the protective effects of Gastrodia elata Blume (GEB) on hepatic and renal injury induced by AAP. Rats were orally administered distilled water or GEB for 14 days and injected with AAP 1 h after the oral last administration; control rats were administered water without AAP injection. All rats were sacrificed ...
DOI:
10.1007/s10068-018-0374-5

103. Solving Donor Organ Shortage with Insights from Freeze Tolerance in Nature: Activating endogenous antioxidant systems with non‐coding RNA to precondition donor organs

Author:
Luu, Bryan E.; Storey, Kenneth B.
Source:
BioEssays 2018 v.40 no.10 pp. e1800092
ISSN:
0265-9247
Subject:
rats,   etc   ; hepatocytes; Lithobates sylvaticus; freezing; liver; winter; humans; cryopreservation; glucose; non-coding RNA; spring; microRNA; frogs; antioxidants; physiological response; thawing; ice; cold tolerance; cold; oxidative stress;     Show all 20 Subjects
Abstract:
... The North American wood frog, Rana sylvatica, endures seasonal whole‐body freezing during the winter and thawing during the spring without sustaining any apparent damage from ice or oxidative stress. Strategies from these frogs may solve the shortage of human donor organs, which is a multidisciplinary problem that can be alleviated by eliminating geographical boundaries. Rana sylvatica deploys an ...
DOI:
10.1002/bies.201800092

104. Oxidative stress promotes redistribution of TRPM2 channels to the plasma membrane in hepatocytes

Author:
Kheradpezhouh, Ehsan; Zhou, Fiona H.; Barritt, Greg J.; Rychkov, Grigori Y.
Source:
Biochemical and biophysical research communications 2018 v.503 no.3 pp. 1891-1896
ISSN:
0006-291X
Subject:
rats,   etc   ; Western blotting; acetaminophen; antibodies; biotinylation; calcium; cell death; confocal microscopy; fluorescent antibody technique; hepatocytes; hydrogen peroxide; ion channels; liver; mice; oxidative stress; plasma membrane;     Show all 16 Subjects
Abstract:
... Transient Receptor Potential Melastatin (TRPM) 2 is a non-selective Ca2+ permeable cation channel and a member of the Transient Receptor Potential (TRP) channel family. TRPM2 has unique gating properties; it is activated by intracellular ADP-ribose (ADPR), whereas Ca2+ plays a role of an important co-factor in channel activation, increasing TRPM2 sensitivity to ADPR. TRPM2 is highly expressed in r ...
DOI:
10.1016/j.bbrc.2018.07.132

105. Protective effects of a natural herbal compound quercetin against snake venom-induced hepatic and renal toxicities in rats

Author:
Al-Asmari, Abdulrahman K.; Khan, Haseeb A.; Manthiri, Rajamohamed A.; Al-Khlaiwi, Ahmad A.; Al-Asmari, Bayan A.; Ibrahim, Khalid E.
Source:
Food and chemical toxicology 2018 v.118 pp. 105-110
ISSN:
0278-6915
Subject:
rats,   etc   ; Echis; antidotes; atrophy; biomarkers; blood serum; hepatocytes; histopathology; kidneys; lipid peroxidation; liver; oxidative stress; protective effect; quercetin; renal function; snake venoms; snakes; thiols; toxicity; toxicology;     Show all 20 Subjects
Abstract:
... Echis pyramidum is a highly poisonous viper snake. Previous studies have shown acute phase hepatic and renal toxicities of Echis pyramidum venom (EPV) in rats. This study reports the protective effects of a natural herbal compound quercetin (QRC) on EPV-induced hepatic and renal toxicities in rats. A singly injection of EPV (4.76 mg/kg) caused significant increase in serum biomarkers of liver and ...
DOI:
10.1016/j.fct.2018.05.016

106. Whole sorghum flour improves glucose tolerance, insulin resistance and preserved pancreatic islets function in obesity diet-induced rats

Author:
Moraes, Érica Aguiar; Marineli, Rafaela da Silva; Lenquiste, Sabrina Alves; Queiroz, Valéria Aparecida Vieira; Camargo, Rafael Ludemann; Borck, Patricia Cristine; Carneiro, Everardo Magalhães; Maróstica Júnior, Mário Roberto
Source:
Journal of functional foods 2018 v.45 pp. 530-540
ISSN:
1756-4646
Subject:
rats,   etc   ; Sorghum (Poaceae); antioxidants; blood lipids; bran; glucose; glucose tolerance; homeostasis; insulin; insulin resistance; insulin secretion; islets of Langerhans; lipid peroxidation; liver; obesity; oxidative stress; sorghum flour;     Show all 17 Subjects
Abstract:
... The effects of sorghum flour fractions (whole and decorticated flours and bran) were evaluated for oxidative stress and obesity parameters in diet-induced obese rats. Compared to high fat-fructose groups, sorghum flour fractions reduced liver fat and whole sorghum flour decreased fasting glucose, improved glucose tolerance, insulin resistance and reduced insulin secretion. Sorghum showed a slight ...
DOI:
10.1016/j.jff.2017.03.047

107. l- Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway

Author:
Liang, Mingcai; Wang, Zhengxuan; Li, Hui; Cai, Liang; Pan, Jianghao; He, Hongjuan; Wu, Qiong; Tang, Yinzhao; Ma, Jiapei; Yang, Lin
Source:
Food and chemical toxicology 2018 v.115 pp. 315-328
ISSN:
0278-6915
Subject:
rats,   etc   ; antioxidant activity; antioxidants; arginine; body weight; catalase; essential amino acids; genes; glutathione; liver; males; messenger RNA; oral administration; oxidative stress; proteins; superoxide dismutase; toxicology;     Show all 17 Subjects
Abstract:
... Arginine is a conditionally essential amino acid. To elucidate the influence of l-arginine on the activation of endogenous antioxidant defence, male Wistar rats were orally administered daily with l-arginine at different levels of 25, 50, 100 mg/100 g body weight. After 7 and 14 days feeding, the antioxidative capacities and glutathione (GSH) contents in the plasma and in the liver were uniformly ...
DOI:
10.1016/j.fct.2018.03.029

108. A preliminary exploration of the potential of Eugenia uvalha Cambess juice intake to counter oxidative stress

Author:
Lopes, J.M.M.; Lage, N.N.; Guerra, J.F.C.; Silva, M.; Bonomo, L.F.; Paulino, A.H.S.; Regis, A.L.R.S.; Pedrosa, M.L.; Silva, M.E.
Source:
Food research international 2018 v.105 pp. 563-569
ISSN:
0963-9969
Subject:
rats,   etc   ; Eugenia pyriformis; antioxidant activity; antioxidants; catalase; enzyme activity; females; fruits; glutathione; high fat diet; juices; liver; markets; metabolic diseases; oxidation; oxidative stress; phytotherapy; proteins; Brazil;     Show all 19 Subjects
Abstract:
... The ability of foods to aid in the prevention of chronic metabolic diseases, has recently become an area of increased interest. In addition, there is growing interest in exploring the benefits of consuming underutilized fruits as alternatives to commercially available fruits. Eugenia uvalha Cambess (uvaia) is a native fruit of Brazil with great market and phytotherapy potential. The present study ...
DOI:
10.1016/j.foodres.2017.11.067

109. Assessment of Titanium Dioxide Nanoparticles (TiO2-NPs) Induced Hepatotoxicity and Ameliorative Effects of Cinnamomum cassia in Sprague-Dawley Rats

Author:
Shakeel, Muhammad; Jabeen, Farhat; Iqbal, Rehana; Chaudhry, AbdulShakoor; Zafar, Sadia; Ali, Muhammad; Khan, MuhammadSaleem; Khalid, Adeel; Shabbir, Samina; Asghar, MuhammadSaleem
Source:
Biological trace element research 2018 v.182 no.1 pp. 57-69
ISSN:
0163-4984
Subject:
rats,   etc   ; Cinnamomum aromaticum; antioxidants; bark; body weight; cinnamon; hepatotoxicity; histology; in vivo studies; liver; nanoparticles; oral administration; oxidative stress; protective effect; titanium dioxide;     Show all 15 Subjects
Abstract:
... This study assessed the protective effects of Cinnamomum cassia (cinnamon) bark extract in rats exposed to titanium dioxide nanoparticles or titanium dioxide bulk salt. For in vivo evaluation of the ameliorative role of the cinnamon extract, the experimental groups were orally administered with the cinnamon extract at different dose levels (50 or 100 or 150 mg/kg bodyweight) along with the subcuta ...
DOI:
10.1007/s12011-017-1074-3

110. Comparative proteomic analysis of hepatic effects induced by nanosilver, silver ions and nanoparticle coating in rats

Author:
Juling, Sabine; Böhmert, Linda; Lichtenstein, Dajana; Oberemm, Axel; Creutzenberg, Otto; Thünemann, Andreas F.; Braeuning, Albert; Lampen, Alfonso
Source:
Food and chemical toxicology 2018 v.113 pp. 255-266
ISSN:
0278-6915
Subject:
rats,   etc   ; coatings; complement; data collection; energy metabolism; homeostasis; ions; liver; nanoparticles; nanosilver; oxidative stress; proteins; proteomics; silver; stress response; toxicity; toxicology;     Show all 17 Subjects
Abstract:
... The presence of nano-scaled particles in food and food-related products has drawn attention to the oral uptake of nanoparticles and their interactions with biological systems. In the present study, we used a toxicoproteomics approach to allow for the untargeted experimental identification and comparative analysis of cellular responses in rat liver after repeated-dose treatment with silver nanopart ...
DOI:
10.1016/j.fct.2018.01.056

111. Long-Term Excessive Selenium Supplementation Induces Hypertension in Rats

Author:
Grotto, Denise; Carneiro, MariaFernanda Hornos; de Castro, MicheleMazzaron; Garcia, SolangeCristina; Barbosa Junior, Fernando
Source:
Biological trace element research 2018 v.182 no.1 pp. 70-77
ISSN:
0163-4984
Subject:
rats,   etc   ; biomarkers; blood; body weight; feed supplements; glutathione peroxidase; hypertension; kidneys; liver; males; oxidative stress; risk; selenium; selenoproteins; sodium selenite; systolic blood pressure; toxicity;     Show all 17 Subjects
Abstract:
... Selenium (Se) is an essential trace element involved in several biological pathways, naturally found in rocks, soils, and food. Even though the daily requirement of Se is achieved through a balanced diet, the use of Se supplements has been frequent. Due to the risk of toxic effects of having Se in excess, supplementation is still under debate. The aim was to evaluate the effects of long-term Se su ...
DOI:
10.1007/s12011-017-1076-1

112. A comprehensive in vitro and in vivo metabolism study of hydroxysafflor yellow A

Author:
Wu, Liang; Tang, Yuping; Shan, Chenxiao; Chai, Chuan; Zhou, Zhu; Shi, Xuqin; Ding, Ning; Wang, Jiaying; Lin, Liping; Tan, Renxiang
Source:
Journal of mass spectrometry 2018 v.53 no.2 pp. 99-108
ISSN:
1076-5174
Subject:
rats,   etc   ; Carthamus tinctorius; biotransformation; blood; cardiovascular diseases; feces; glucuronic acid; intravenous injection; ischemia; liver; males; mass spectrometry; metabolism; metabolites; methylation; oxidative stress; pharmacodynamics; urine;     Show all 18 Subjects
Abstract:
... As the most important marker component in Carthamus tinctorius L., hydroxysafflor yellow A (HSYA) was widely used in the prevention and treatment of cardiovascular diseases, due to its effect of improving blood supply, suppressing oxidative stress, and protecting against ischemia/reperfusion. In this paper, both an in vitro microsomal incubation and an in vivo animal experiment were conducted, alo ...
DOI:
10.1002/jms.4041

113. In vitro/in vivo antioxidant and hepatoprotective potential of defatted extract and flavonoids isolated from Astragalus spruneri Boiss. (Fabaceae)

Author:
Kondeva-Burdina, Magdalena; Shkondrov, Aleksandar; Simeonova, Rumyana; Vitcheva, Vessela; Krasteva, Ilina; Ionkova, Iliana
Source:
Food and chemical toxicology 2018 v.111 pp. 631-640
ISSN:
0278-6915
Subject:
rats,   etc   ; Astragalus; antioxidants; catalase; cell viability; hepatocytes; hepatoprotective effect; high performance liquid chromatography; lipid peroxidation; liver; liver microsomes; mass spectrometry; models; oxidative stress; saponins; silymarin; superoxide dismutase; toxicology;     Show all 18 Subjects
Abstract:
... The aim of the current study was to evaluate the effect of a defatted extract (EAS) and three flavonoids, isolated from Astragalus spruneri Boiss. (Fabaceae) using in vitro/in vivo models of liver injury. The EAS was characterized by HPLC and flavonoids (14 mg/g dw) and saponins (8 mg/g dw) were proved. The flavonoids (ASF1, ASF3 and ASF5) were isolated from the same extract and partially identifi ...
DOI:
10.1016/j.fct.2017.12.020

114. Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats

Author:
Parvez, Mohammad K.; Al-Dosari, Mohammed S.; Arbab, Ahmed H.; Alam, Perwez; Alsaid, Mansour S.; Khan, Azmat A.
Source:
BMC complementary and alternative medicine 2019 v.19 no.1 pp. 154
ISSN:
1472-6882
Subject:
rats,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Solanum virginianum; alkaline phosphatase; alkaloids; alternative medicine; antioxidant activity; apoptosis; beta-sitosterol; bilirubin; bleaching; blood chemistry; blood serum; carbon tetrachloride; cholesterol; flavonoids; free radical scavengers; hepatoprotective effect; high performance liquid chromatography; histopathology; human cell lines; leaf extracts; leaves; linoleic acid; liver; liver diseases; malondialdehyde; mechanism of action; oxidative stress; protein content; saponins; sulfhydryl groups; tannins; toxicity; toxicity testing; transaminases; triacylglycerols;     Show all 37 Subjects
Abstract:
... BACKGROUND: Of over 35 Saudi plants traditionally used to treat liver disorders, majority still lack scientific validations. We therefore, evaluated the anti-oxidative, anti-apoptotic and hepatoprotective potential of Solanum surattense leaves total ethanol-extract (SSEE). METHODS: The cytoprotective (4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide/ MTT assay) and anti-apoptotic (caspase- ...
DOI:
10.1186/s12906-019-2553-1

115. The remedial effect of Thymus vulgaris extract against lead toxicity-induced oxidative stress, hepatorenal damage, immunosuppression, and hematological disorders in rats

Author:
El-Boshy, Mohamed E.; Refaat, Bassem; Qasem, Ahmed H.; Khan, Anmar; Ghaith, Mazen; Almasmoum, Hussain; Mahbub, Amani; Almaimani, Riyad A.
Source:
Environmental science and pollution research international 2019 v.26 no.22 pp. 22736-22746
ISSN:
0944-1344
Subject:
rats,   etc   ; Thymus vulgaris; acetates; alanine transaminase; albumins; alkaline phosphatase; antioxidant activity; antioxidants; aspartate transaminase; bilirubin; biomarkers; blood sampling; blood serum; calcium; catalase; creatinine; drinking water; flavor; foods; glutathione; glutathione peroxidase; histopathology; immunosuppression; interferon-gamma; interleukin-10; interleukin-1beta; interleukin-6; kidneys; lead; leaf extracts; lipid peroxidation; liver; males; malondialdehyde; medicinal plants; necrosis; neoplasms; odors; oxidative stress; protective effect; protein content; superoxide dismutase; tissues; toxicity; traditional medicine; tumor necrosis factor-alpha; urea;     Show all 47 Subjects
Abstract:
... The Thymus vulgaris (T. vulgaris) has been used in foods for the flavor, aroma, and preservation and in folk medicines. The objective of the present work was to determine the antioxidant and protective effects of T. vulgaris extract against lead (Pb)-intoxicated rats. A thirty-two male Sprague-Dawley were randomly assigned into 4 equal groups and treated for six weeks as follows: group I (GP-I), s ...
DOI:
10.1007/s11356-019-05562-8

116. Xian-Ling-Gu-Bao induced inflammatory stress rat liver injury: Inflammatory and oxidative stress playing important roles

Author:
Wu, Wenxiao; Wang, Ting; Sun, Bo; Liu, Dong; Lin, Zhi; Miao, Yufa; Wang, Chao; Geng, Xingchao; Li, Bo
Source:
Journal of ethnopharmacology 2019 v.239 pp. 111910
ISSN:
0378-8741
Subject:
rats,   etc   ; NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); adenine; alanine transaminase; animal models; apoptosis; aspartate transaminase; bilirubin; blood chemistry; blood serum; carboxymethylcellulose; chemoattractants; climacteric fruits; cytochrome P-450; cytokines; fluorescent antibody technique; gamma-glutamyltransferase; hepatocytes; hepatotoxicity; histopathology; immunohistochemistry; inducible nitric oxide synthase; inflammation; intravenous injection; lipid metabolism; lipopolysaccharides; liver; liver function; males; microscopy; neutrophils; oral administration; osteoarthritis; osteonecrosis; osteoporosis; oxidative stress; phosphates; protein content; solvents; staining; traditional medicine; triacylglycerols;     Show all 43 Subjects
Abstract:
... Xian-Ling-Gu-Bao (XLGB) Fufang is an herbal formula that has been used in clinical settings to treat osteoporosis, osteoarthritis, aseptic bone necrosis, and climacteric syndrome. Despite its uses, XLGB treatment has been linked to potential liver injury. To date, there is a lack of clear demonstration of such toxicity in animal models.As animal models fail to reproduce the XLGB hepatotoxicity rep ...
DOI:
10.1016/j.jep.2019.111910

117. Ameliorative impact of cold‐pressed Rosmarinus officinalis oil against liver toxicity and genotoxic effects in streptozotocin‐induced diabetic rats and their offspring

Author:
El‐Beeh, Mohamed E.; Aljabri, Maha; Orabi, Hisham F.; Qari, Sameer H.; Ramadan, Mohamed Fawzy
Source:
Journal of food biochemistry 2019 v.43 no.7 pp. e12905
ISSN:
0145-8884
Subject:
rats,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; DNA fragmentation; Rosmarinus officinalis; albino; animal disease models; antioxidant activity; bioactive compounds; blood glucose; comet assay; delta-tocopherol; diabetes mellitus; dietary supplements; embryogenesis; fetus; free radicals; genotoxicity; glucose; glycemic effect; hepatotoxicity; histology; homeostasis; human health; ingredients; insulin; liver; mechanism of action; metabolism; monounsaturated fatty acids; nitrogen dioxide; novel foods; nucleobases; oils; oxidative stress; patients; photographs; phytochemicals; polyunsaturated fatty acids; progeny; reactive nitrogen species; saturated fatty acids; streptozotocin; therapeutics;     Show all 43 Subjects
Abstract:
... Diabetes mellitus (DM) is a chronic, lifelong condition threatening human health. Rosmarinus officinalis oil (RO) could have a future role in DM therapy. This study evaluated the composition and antioxidative potential of RO. Antidiabetic traits of RO in streptozotocin (STZ)‐induced diabetic rats was also studied considering the ameliorative impact against embryogenesis defects using in vitro and ...
DOI:
10.1111/jfbc.12905

118. Anti-obesity effect of argel (Solenostemma argel) on obese rats fed a high fat diet

Author:
El-shiekh, Riham A.; Al-Mahdy, Dalia A.; Mouneir, Samar M.; Hifnawy, Mohamed S.; Abdel-Sattar, Essam A.
Source:
Journal of ethnopharmacology 2019 v.238 pp. 111893
ISSN:
0378-8741
Subject:
rats,   etc   ; adipokines; adipose tissue; aerial parts; animal disease models; anti-inflammatory agents; anti-obesity agents; appetite; beta oxidation; biomarkers; blood sampling; butanol; carboxylic ester hydrolases; diabetes; enzyme inhibition; fatty liver; gene expression; genes; glucose; glycosides; high fat diet; histopathology; insulin; lipid composition; lipid peroxidation; liquid chromatography; liver; males; mass spectrometry; mechanism of action; methylene chloride; obesity; oxidative stress; parasympatholytics; pregnanes; therapeutics; traditional medicine; weight gain; xerophytes;     Show all 39 Subjects
Abstract:
... Solenostemma argel (Argel) is a desert plant commonly used in Egyptian and Sudanese traditional medicine to suppress appetite, for treatment of diabetes, and as an antispasmodic and anti-inflammatory agent. Previously the anti-diabetic, hypolipidemic and lipase inhibitory activities of Argel were reported in animal studies and in-vitro assays. However, its specific mechanism of action as an anti-o ...
DOI:
10.1016/j.jep.2019.111893

119. Protective effect and mechanism of Qiwei Tiexie capsule on 3T3-L1 adipocytes cells and rats with nonalcoholic fatty liver disease by regulating LXRα, PPARγ, and NF-κB-iNOS-NO signaling pathways

Author:
Suolang, Ping-Cuo; Liu, Bao-Qing; Chen, Jing; De, Ji; Nima, Zha-Ba; Dunzhu, Ci-Ren
Source:
Journal of ethnopharmacology 2019 v.236 pp. 316-325
ISSN:
0378-8741
Subject:
rats,   etc   ; IKappaB kinase; Western blotting; adipocytes; animal models; biomarkers; blood serum; carnitine; chemokine CCL2; cytochrome P-450; cytotoxicity; emulsions; fatty liver; glucose; inducible nitric oxide synthase; inflammation; lipid metabolism; liver; liver function; malondialdehyde; nitric oxide; oxidation; oxidative stress; palmitic acid; peroxisome proliferator-activated receptors; polymerase chain reaction; protective effect; signal transduction; staining; sucrose; superoxide dismutase; traditional medicine; transcription factor NF-kappa B; transmission electron microscopes; vacuoles;     Show all 35 Subjects
Abstract:
... Qiwei Tiexie capsule (QWTX) is a representative prescription of Tibetan medicine, which is widely used for long-term treatment of chronic liver disease and nonalcoholic fatty liver disease (NAFLD).This study explored the effects and mechanism of QWTX on 3T3-L1 adipocytes and NAFLD.The 3T3-L1 preadipocytes and NAFLD rat model were used in the study. In 3T3-L1 cells, the cytotoxicity of QWTX was tes ...
DOI:
10.1016/j.jep.2019.03.006

120. The hepatoprotective effects of Sedum sarmentosum extract and its isolated major constituent through Nrf2 activation and NF-κB inhibition

Author:
Wang, Guo-Wei; Zhang, Xiao-Long; Wu, Qing-Hua; Jin, Yong-Biao; Ning, Chun-Tao; Wang, Rui; Mao, Jing-Xin; Chen, Min
Source:
Phytomedicine 2019 v.53 pp. 263-273
ISSN:
0944-7113
Subject:
rats,   etc   ; IKappaB kinase; Sedum sarmentosum; Western blotting; alanine transaminase; alkaline phosphatase; antioxidant activity; aspartate transaminase; bile; biomarkers; blood serum; chemical constituents of plants; dose response; gall bladder; glutathione peroxidase; hepatoprotective effect; high performance liquid chromatography; histopathology; humans; inflammation; interferon-gamma; interleukin-1beta; interleukin-4; interleukin-6; liver; oxidative stress; protein synthesis; spectral analysis; superoxide dismutase; survival rate; transcription factor NF-kappa B; tumor necrosis factor-alpha;     Show all 32 Subjects
Abstract:
... Sedum sarmentosum, which is recorded in Chinese Pharmacopoeia, has been applied clinically to treat liver and gallbladder diseases.This study aimed to explore the hepatoprotective effect of S. sarmentosum less polar extract (SSE) against ANIT-induced liver injury in rats, and the protective activity and mechanism of one major constituent isolated from this extract on D-GalN-induced human hepatic Q ...
DOI:
10.1016/j.phymed.2018.09.023