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- Liu, Luming, et al. Show all 12 Authors
- The Science of the total environment 2018 v.645 pp. 363-371
- DNA fragmentation; apoptosis; autophagy; blood serum; brain; caspase-12; caspase-3; endoplasmic reticulum; epithelial cells; females; fetus; flame retardants; gene expression regulation; infants; laboratory animals; mechanism of action; neurotoxicity; progeny; rats; triiodothyronine; unfolded protein response; weaning
- ... Brominated flame retardant 2,2′,4,4′‑tetrabromodiphenyl ether (PBDE-47) is known to induce developmental neurotoxicity by disturbing thyroid hormones (THs). Evidence shows that maternal THs are crucial for brain development and growth of fetuses and infants. However, little is known about the effects of PBDE-47 on maternal thyroid status and its mode of action. Here, using female Sprague-Dawley ra ...
- Liu, Luming, et al. Show all 13 Authors
- Chemosphere 2019 v.233 pp. 174-182
- adiposity; adulthood; adults; amino acids; biochemical pathways; blood serum; carbohydrates; children; conception; females; gas chromatography-mass spectrometry; lipids; males; malnutrition; metabolites; metabolome; metabolomics; obesity; polybrominated diphenyl ethers; pups; rats
- ... Emerging evidence suggests environmental contaminant exposures during critical windows of development may contribute to the increasing prevalence of obesity. It has been shown that early life polybrominated diphenyl ethers exposures have critical impacts on child weight trajectories, however, little is known about their maternal mechanisms responsible for offspring obesity development. In this stu ...