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1. Lonicera japonica extract increases metformin distribution in the liver without change of systemic exposed metformin in rats

Author:
Chin, Young-Won,   et al.   ; Han, Seung Yon; Chae, Hee-Sung; You, Byoung Hoon; Kim, Hojun; Choi, Han Seok; Choi, Young Hee;     Show all 7 Authors
Source:
Journal of ethnopharmacology 2019 v.238 pp. 111892
ISSN:
0378-8741
Subject:
Lonicera japonica; bile; cations; drug interactions; ethanol; extrusion; flower buds; flowers; glucose; glucose tolerance; heat; hepatocytes; kidneys; liver; medicinal plants; metformin; pharmacokinetics; rats; thirst; tissue distribution; traditional medicine; transporters; vision
Abstract:
... Flower and flower bud of Lonicera japonica, Lonicerae Flos, have been popularly used as medicinal plant for the treatment of clearing heat and thirst, thereby improving diabetic or diabetic associated symptoms (thirst and poor eyesight).Organic cation transporters (OCTs) and multi-drug and toxin extrusion proteins (MATEs) are known to play important roles in metformin transport in the liver and ki ...
DOI:
10.1016/j.jep.2019.111892

2. Houttuynia cordata extract increased systemic exposure and liver concentrations of metformin through OCTs and MATEs in rats

Author:
Chin, Young‐Won,   et al.   ; You, Byoung Hoon; Kim, Hojun; Choi, Han Seok; Choi, Young Hee;     Show all 5 Authors
Source:
Phytotherapy research 2018 v.32 no.6 pp. 1004-1013
ISSN:
0951-418X
Subject:
Houttuynia cordata; animal disease models; diabetes; ethanol; excretion; glycemic effect; humans; hypoglycemia; kidneys; liver; medicinal properties; metformin; organic cation transporters; pharmacokinetics; rats; renal function; synergism; therapeutics
Abstract:
... The synergistic activity of Houttuynia cordata ethanol extract (HCT) and metformin combination in diabetic rats has been previously reported, but the fundamental causes remain unsolved. Organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs) transport metformin to the liver and kidneys. Therefore, pharmacological activity and systemic exposure of metformin in HCT–metf ...
DOI:
10.1002/ptr.6036

3. Effects of Korean red ginseng extract on acute renal failure induced by gentamicin and pharmacokinetic changes by metformin in rats

Author:
Chin, Young-Won,   et al.   ; Lee, Yu Kyung; Choi, Young Hee;     Show all 3 Authors
Source:
Food and chemical toxicology 2013 v.59 pp. 153-159
ISSN:
0278-6915
Subject:
Panax; antibiotic resistance; bacterial infections; combination drug therapy; diabetic complications; dietary supplements; drug interactions; gentamicin; kidneys; metformin; patients; pharmacokinetics; rats; renal failure; renal function
Abstract:
... Korean red ginseng is one of the best selling dietary supplements and its individual constituents enhance renal function. Acute renal failure (ARF) is a predisposing complication of diabetes mellitus as a result of combination drug therapy. The combination of antibiotic–antidiabetic drugs can entail toxicities and drug interactions because of the antibiotic resistance in patients with severe bacte ...
DOI:
10.1016/j.fct.2013.05.025

4. Simultaneous determination of nine lignans from Schisandra chinensis extract using ultra‐performance liquid chromatography with tandem mass spectrometry in rat plasma, urine, and gastrointestinal tract samples: Application to the pharmacokinetic study of Schisandra chinensis

Author:
Chin, Young‐Won,   et al.   ; Kim, You‐Jin; Lee, Hee Ju; Kim, Chul Young; Han, Sun‐Young; Choi, Young Hee;     Show all 6 Authors
Source:
Journal of separation science 2014 v.37 no.20 pp. 2851-2863
ISSN:
1615-9306
Subject:
Schisandra chinensis; dietary supplements; gastrointestinal system; herbal medicines; intravenous injection; lignans; oral administration; pharmacokinetics; rats; tandem mass spectrometry; ultra-performance liquid chromatography; urine
Abstract:
... The fruit of Schisandra chinensis is a well‐known herbal medicine and dietary supplement due to a variety of biological activities including antihepatotoxic and antihyperlipidemic activities. However, the simultaneous validation methodology and pharmacokinetic investigation of nine lignans of S. chinensis extract in biological samples have not been proved yet. Thus, the present study was undertake ...
DOI:
10.1002/jssc.201400451
PubMed:
25113775

5. Effects of cysteine on the pharmacokinetics of paclitaxel in rats

Author:
Chin, Young-Won,   et al.   ; Lee, Yu Kyung; Han, Seung Yon; Choi, Young Hee;     Show all 4 Authors
Source:
Archives of pharmacal research 2012 v.35 no.3 pp. 509-516
ISSN:
0253-6269
Subject:
cysteine; intestinal absorption; intestines; intravenous injection; isozymes; liver; oral administration; paclitaxel; pharmacokinetics; rats
Abstract:
... Paclitaxel is a P-gp substrate and metabolized via CYP2C and 3A subfamily in rats. It has been reported that cysteine causes the changes in expression of CYP isozymes and intestinal P-gp mediated efflux activity in rats. Thus, the effects of cysteine on the pharmacokinetics of intravenous and oral paclitaxel were investigated in rats. After intravenous administration of paclitaxel (30 mg/kg) to co ...
DOI:
10.1007/s12272-012-0314-5

6. Essential Oils from the Medicinal Herbs Upregulate Dopamine Transporter in Rat Pheochromocytoma Cells

Author:
Chin, Young-Won,   et al.   ; Choi, Min Sun; Choi, Bang-sub; Kim, Sang Heon; Pak, Sok Cheon; Jang, Chul Ho; Kim, Young-Mi; Kim, Dong-il; Jeon, Songhee; Koo, Byung-Soo;     Show all 10 Authors
Source:
Journal of medicinal food 2015 v.18 no.10 pp. 1112-1120
ISSN:
1557-7600
Subject:
Elsholtzia ciliata; dopamine; immunoblotting; cell viability; cyclic AMP; cytotoxicity; relapse; brain; essential oils; medicinal plants; therapeutics; amphetamine; Syzygium aromaticum; phosphorylation; rats; drug abuse; mitogen-activated protein kinase
Abstract:
... The dopamine transporter (DAT) protein, a component of the dopamine system, undergoes adaptive neurobiological changes from drug abuse. Prevention of relapse and reduction of withdrawal symptoms are still the major limitations in the current pharmacological treatments of drug addiction. The present study aimed to investigate the effects of essential oils extracted from Elsholtzia ciliata, Shinchim ...
DOI:
10.1089/jmf.2015.3475

7. Evaluation of the cholinergic and adrenergic effects of two tropane alkaloids from Erythroxylum pervillei

Author:
Chin, Young-Won,   et al.   ; Kinghorn, A. Douglas; Patil, Popat N.;     Show all 3 Authors
Source:
Phytotherapy research 2007 v.21 no.10 pp. 1002-1005
ISSN:
0951-418X
Subject:
drug therapy; ileum; smooth muscle; multiple drug resistance; tropane alkaloids; Erythroxylum; aorta; rats
Abstract:
... Pervilleine A is an aromatic ester tropane alkaloid from Erythroxylum pervillei that has shown promising activity as a multidrug resistance inhibitor. Due to its structural similarity with the well known (-)-hyoscyamine and (-)-cocaine, the cholinergic and adrenergic activities of pervilleine A were evaluated. At 30 μm (±)-pervilleine A hydrochloride exhibited non-competitive inhibition of the cho ...
DOI:
10.1002/ptr.2155
PubMed:
17602438
PubMed Central:
PMC2798816