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- Okuno, M., et al. Show all 7 Authors
- Nutrition and cancer 1998 v.32 no.1 pp. 20-24
- alpha-carotene; beta-carotene; canthaxanthin; colon; neoplasms; retinoic acid; viability; DNA; biosynthesis; cell division; receptors; genes; messenger RNA; gene expression; cell lines; humans
- ... The present study employed two human colon cancer cell lines, DLD-1 and Colo 320DM, to investigate whether the provitamin A activity of carotenoids is necessary for their antitumor effect on colon cancer. Carotenoids, including alpha- and beta-carotene and canthaxanthin, significantly suppressed cell viability [measured by tetrazolium (MTT) assay], DNA synthesis (measured by (3H]thymidine uptake), ...
- Okuno, M., et al. Show all 6 Authors
- Nutrition and cancer 1996 v.26 no.2 pp. 203-208
- carcinogenesis; metabolism; messenger RNA; canthaxanthin; liver; blood serum; body weight; proto-oncogenes; mice; beta-carotene; antineoplastic agents; gene expression; growth retardation; retinoic acid; carcinogens; papilloma; dietary supplements
- ... Using mouse skin papilloma as a model system, we examined whether the antitumorigenic activity of carotenoids was related to their provitamin A activity. Oral administration of canthaxanthin (CX) or beta-carotene at 200 mg/kg/day for 14 days significantly reduced the cumulative size of papillomas induced on the skin by 9,10-dimethyl-1,2-benzanthracene (p < 0.05), after the accumulation of these ca ...