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- Schaffer, David V., et al. Show all 9 Authors
- Biomaterials 2017
- Parkinson disease; brain; cell viability; clinical trials; encapsulation; heparin; humans; hyaluronic acid; hydrogels; manufacturing; models; neurons; phenotype; rats; stem cells
- ... Cell replacement therapies have broad biomedical potential; however, low cell survival and poor functional integration post-transplantation are major hurdles that hamper clinical benefit. For example, following striatal transplantation of midbrain dopaminergic (mDA) neurons for the treatment of Parkinson's disease (PD), only 1–5% of the neurons typically survive in preclinical models and in clinic ...