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1. 23-Valent Pneumococcal Polysaccharide Vaccination Does Not Prevent Community-Acquired Pneumonia Hospitalizations Due to Vaccine-Type Streptococcus pneumoniae

Author:
Thomas Chandler; Stephen Furmanek; Ruth Carrico; Dawn Balcom; Forest Arnold; Julio Ramirez
Source:
Microorganisms 2022 v.10 no.3 pp. -
ISSN:
2076-2607
Subject:
Streptococcus pneumoniae; adults; antigen detection; experimental design; pneumonia; polysaccharides; primary contact; regression analysis; serotypes; vaccination; vaccines
Abstract:
... Controversy exists regarding the clinical effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) for the prevention of serotype-specific community-acquired pneumonia (CAP). The objective of this study was to define the effectiveness of PPSV23 for the prevention of CAP hospitalizations due to vaccine-contained serotypes. This secondary analysis was a nested case–control, test-n ...
DOI:
10.3390/microorganisms10030560

2. A Brucella melitensis H38ΔwbkF rough mutant protects against Brucella ovis in rams

Author:
Pilar M. Muñoz; Raquel Conde-Álvarez; Sara Andrés-Barranco; María-Jesús de Miguel; Amaia Zúñiga-Ripa; Beatriz Aragón-Aranda; Miriam Salvador-Bescós; Estrella Martínez-Gómez; Maite Iriarte; Montserrat Barberán; Nieves Vizcaíno; Ignacio Moriyón; José M. Blasco
Source:
BMC veterinary research 2022 v.53 no.1 pp. 16
ISSN:
1297-9716
Subject:
Brucella melitensis biovar Ovis; antibody formation; brucellosis; complement; epitopes; humans; lipopolysaccharides; live vaccines; monitoring; mutants; oligosaccharides; precipitin tests; serodiagnosis; vaccination; veterinary medicine
Abstract:
... Brucella melitensis and Brucella ovis are gram-negative pathogens of sheep that cause severe economic losses and, although B. ovis is non-zoonotic, B. melitensis is the main cause of human brucellosis. B. melitensis carries a smooth (S) lipopolysaccharide (LPS) with an N-formyl-perosamine O-polysaccharide (O-PS) that is absent in the rough LPS of B. ovis. Their control and eradication require vacc ...
DOI:
10.1186/s13567-022-01034-z

3. A Comparative Evaluation of the Estimation of Rabies Virus Antibodies among Free-Roaming, Vaccinated Dogs in Bengaluru, India

Author:
Lekshmi J. Das; Shrikrishna Isloor; Alur Kotrappa Santosh; Avinash Bhat; Ramakrishnaiah Sharada; Doddamane Rathnamma; Belamaranahally Muniveerappa Veeregowda; Konanduru Lingappa Phaniraj; Nageshkumar Abhijit Kumar; Abi T. Vanak
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Rabies lyssavirus; blood serum; dogs; fluorescent antibody technique; immunogenicity; rabies; vaccination; India
Abstract:
... Vaccination is the practical solution for the prevention of rabies in dogs. Assessment of the immunogenicity of vaccination includes estimation of specific rabies virus neutralizing antibodies (VNA) in the target species. We undertook a study to estimate the levels of VNA in free-roaming dogs with a history of rabies vaccination in Bengaluru city, India. We compared the rapid fluorescent focus inh ...
DOI:
10.3390/v14030484

4. A Continuous Markov-Chain Model for the Simulation of COVID-19 Epidemic Dynamics

Author:
Zhaobin Xu; Hongmei Zhang; Zuyi Huang
Source:
Biology 2022 v.11 no.2 pp. -
ISSN:
2079-7737
Subject:
COVID-19 infection; Markov chain; basic reproduction number; geographical distribution; herd immunity; herds; innate immunity; models; mutation; population size; prediction; vaccination; viruses
Abstract:
... To address the urgent need to accurately predict the spreading trend of the COVID-19 epidemic, a continuous Markov-chain model was, for the first time, developed in this work to predict the spread of COVID-19 infection. A probability matrix of infection was first developed in this model based upon the contact frequency of individuals within the population, the individual’s characteristics, and oth ...
DOI:
10.3390/biology11020190

5. A Sporothrix spp. enolase derived multi-epitope vaccine confers protective response in BALB/c mice challenged with Sporothrix brasiliensis

Author:
Deivys Leandro Portuondo; Alexander Batista-Duharte; Constanza Cardenas; Carlos S. de Oliveira; Júlio César Borges; Damiana Téllez-Martínez; Paula Andrea Santana; Adriana Gauna; Luis Mercado; Bruna Mateus de Castilho; Paulo Costa; Fanny Guzmán; Iracilda Zeppone Carlos
Source:
Microbial pathogenesis 2022 v.166 pp. 105539
ISSN:
0882-4010
Subject:
B-lymphocytes; Sporothrix; autoimmunity; blood serum; cats; computer simulation; cytokines; epitopes; immunoglobulin G; pathogenesis; phosphopyruvate hydratase; sequence analysis; sporotrichosis; synthesis; vaccination; vaccine adjuvants; vaccine development; vaccines; Brazil
Abstract:
... Sporotrichosis is a cosmopolitan mycosis caused by pathogenic species of Sporothrix genus, that in Brazil is often acquired by zoonotic transmission involved infected cats with S. brasiliensis. Previous studies showed that the Sporothrix spp. recombinant enolase (rSsEno), a multifunctional protein with immunogenic properties, could be a promising target for vaccination against sporotrichosis in ca ...
DOI:
10.1016/j.micpath.2022.105539

6. A Vaccine Based on the A/ASIA/G-VII Lineage of Foot-and-Mouth Disease Virus Offers Low Levels of Protection against Circulating Viruses from the A/ASIA/Iran-05 lineage

Author:
Nagendrakumar Balasubramanian Singanallur; Phaedra Lydia Eblé; Anna Barbara Ludi; Bob Statham; Abdelghani Bin-Tarif; Donald P. King; Aldo Dekker; Wilna Vosloo
Source:
Viruses 2022 v.14 no.1 pp. -
ISSN:
1999-4915
Subject:
Foot-and-mouth disease virus; World Organization for Animal Health; antibodies; antigens; cattle; excretion; serotypes; vaccination; vaccines; viremia; viruses; Middle East
Abstract:
... The recent emergence and circulation of the A/ASIA/G-VII (A/G-VII) lineage of foot-and-mouth disease virus (FMDV) in the Middle East has resulted in the development of homologous vaccines to ensure susceptible animals are sufficiently protected against clinical disease. However, a second serotype A lineage called A/ASIA/Iran-05 (A/IRN/05) continues to circulate in the region and it is therefore im ...
DOI:
10.3390/v14010097

7. A bivalent vaccine against avian necrotic enteritis and coccidiosis

Author:
Mohammad Fatemi Motlagh; S. Latif Mousavi Gargari
Source:
Journal of applied microbiology 2022 v.132 no.1 pp. 113-125
ISSN:
1364-5072
Subject:
Clostridium perfringens; amino acid sequences; antibodies; antigens; birds; coccidiosis; intestines; microbiology; necrotic enteritis; recombinant proteins; recombinant vaccines; rhoptry proteins; toxins; vaccination; virulence
Abstract:
... AIMS: In this study, we attempted to design a recombinant vaccine harbouring domain with a key role in enterocyte attachment and cell invasion in necrotic enteritis (NE) and coccidiosis. METHODS AND RESULTS: In this study, we investigated whether a recombinant protein consisting of necrotic enteritis B‐like toxin, C‐terminal domain of alpha‐toxin, apical membrane antigen 1 (AMA1), and Rhoptry neck ...
DOI:
10.1111/jam.15178

8. A candidate multi-epitope vaccine against porcine reproductive and respiratory syndrome virus and Mycoplasma hyopneumoniae induces robust humoral and cellular response in mice

Author:
Zhisong Gao; Lingxiao Chen; Tao Song; Xuan Pan; Xiaojing Li; Guangzong Lu; Yajie Tang; Xiang Wu; Baohua Zhao; Ran Zhang
Source:
Vaccine 2022 v.40 no.16 pp. 2370-2378
ISSN:
0264-410X
Subject:
B-lymphocytes; Mycoplasma hyopneumoniae; T-lymphocytes; antibodies; cell-mediated immunity; disease prevention; epitopes; hydrophilicity; immune response; peptides; porcine reproductive and respiratory syndrome; pork industry; respiratory tract diseases; swine; vaccination; vaccines; viruses
Abstract:
... Porcine reproductive and respiratory syndrome virus (PRRSV) and Mycoplasma hyopneumoniae (M. hyopneumoniae, Mhp) are two of the most common pathogens involved in the porcine respiratory disease complex (PRDC) resulting in significant economic losses worldwide. Vaccination is the most effective approach to disease prevention. Since PRRSV and Mhp co-infections are very common, an efficient dual vacc ...
DOI:
10.1016/j.vaccine.2022.03.021

9. A comparative review of serological assays for the detection of rabies virus-specific antibodies

Author:
Fernanda Nery Ciconello; Iana Suly Santos Katz; Elaine Raniero Fernandes; Fernanda Guedes; Sandriana Ramos Silva
Source:
Acta tropica 2022 v.226 pp. 106254
ISSN:
0001-706X
Subject:
Rabies lyssavirus; World Health Organization; World Organization for Animal Health; blood serum; cost effectiveness; disease prevention; humans; immune response; monitoring; mortality; neutralization; prototypes; public health; rabies; vaccination; viruses
Abstract:
... Rabies is a major public health problem with a fatality rate close to 100%, caused by a virus of the Lyssavirus genus, of which rabies virus (RABV) is the prototype. Nonetheless, the complete prevention can be achieved by the induction of neutralizing antibodies by pre- or post-exposure prophylaxis. According to the world health organization (WHO) and World Organization for animal health (OIE), se ...
DOI:
10.1016/j.actatropica.2021.106254

10. A comparison of clinical manifestations of Japanese encephalitis between children and adults in Gansu Province, Northwest China (2005–2020)

Author:
Donghua Li; Xiaoshu Zhang; Tianshan Shi; Na Jin; Xiangkai Zhao; Lei Meng; Yanchen Liu; Hongmiao Zheng; Xin Zhao; Juansheng Li; Xiping Shen; Xiaowei Ren
Source:
Acta tropica 2022 v.231 pp. 106449
ISSN:
0001-706X
Subject:
adults; blood pressure; bronchopneumonia; children; complications (disease); consciousness; encephalitis; muscles; public health; vaccination; vaccines; zoonoses; China
Abstract:
... Japanese encephalitis (JE), a mosquito-borne zoonotic disease, has emerged as a major public health concern around the world. Previous research has shown that JE has serious sequelae, and the recent shift in the population from children to adults presents a significant challenge for JE treatment and prevention. Therefore, we examined the differences in clinical manifestations (clinical symptoms, c ...
DOI:
10.1016/j.actatropica.2022.106449

11. A comparison of national vaccination policies to prevent serogroup B meningococcal disease

Author:
Giorgia Sulis; Miranda Horn; Ray Borrow; Nicole E. Basta
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
Internet; issues and policy; landscapes; monitoring; risk; serotypes; vaccination; vaccines
Abstract:
... To understand the global landscape of prevention and control efforts targeting serogroup B meningococcal (MenB) disease and to identify the key challenges and gaps yet to be addressed. We conducted a comprehensive review of policies and practices for the use of protein-based MenB vaccines (Bexsero® [GlaxoSmithKline] and Trumenba® [Pfizer]) in all countries (n = 58) where either or both vaccine is ...
DOI:
10.1016/j.vaccine.2022.04.101

12. A decade of data: Adolescent vaccination in the vaccine safety datalink, 2007 through 2016

Author:
Stephanie A. Irving; Holly C. Groom; Padma Dandamudi; Matthew F. Daley; James G. Donahue; Julianne Gee; Rulin Hechter; Lisa A. Jackson; Nicola P. Klein; Elizabeth Liles; Tanya R. Myers; Shannon Stokley
Source:
Vaccine 2022 v.40 no.9 pp. 1246-1252
ISSN:
0264-410X
Subject:
COVID-19 infection; adolescents; cohort studies; diphtheria; humans; tetanus; vaccination; vaccines
Abstract:
... Between May 2005 and March 2007, three vaccines were recommended by the Advisory Committee on Immunization Practices for routine use in adolescents in the United States: quadrivalent meningococcal conjugate vaccine (MenACWY), tetanus, diphtheria and acellular pertussis vaccine (Tdap), and human papillomavirus vaccine (HPV). Understanding historical adolescent vaccination patterns may inform future ...
DOI:
10.1016/j.vaccine.2022.01.051

13. A flavivirus-inducible gene expression system that modulates broad-spectrum antiviral activity against dengue and Zika viruses

Author:
Shih-Che Weng; Yu-Xian Zhou; Shin-Hong Shiao
Source:
Insect biochemistry and molecular biology 2022 v.142 pp. 103723
ISSN:
0965-1748
Subject:
Aedes aegypti; Dengue virus; RNA; Zika virus; antiviral properties; apoptosis; caspases; cell lines; dengue; disease control; drug therapy; gene expression; green fluorescent protein; insect biochemistry; molecular biology; mosquito-borne diseases; vaccination; virus replication; viruses
Abstract:
... Incidence of dengue virus (DENV) and Zika virus (ZIKV), two mosquito-borne flaviviruses, is increasing in large parts of the world. Vaccination and medication for these diseases are unsatisfactory. Here, we developed a novel antiviral approach, using a virus-inducible gene expression system, to block virus replication and transmission. Constructs containing the smallest replication units of dengue ...
DOI:
10.1016/j.ibmb.2022.103723

14. A high efficacy DNA vaccine against Tilapia lake virus in Nile tilapia (Oreochromis niloticus)

Author:
Nai-tong Yu; Wei-wei Zeng; Zhongguo Xiong; Zhi-xin Liu
Source:
Aquaculture reports 2022 v.24 pp. 101166
ISSN:
2352-5134
Subject:
Oreochromis niloticus; Tilapia lake virus; Toll-like receptor 2; Western blotting; aquaculture; epitopes; fish; genetic vectors; immunity; interleukin-8; kidneys; liver; plasmids; recombinant vaccines; spleen; tumor necrosis factor-alpha; vaccination; virus replication; viruses
Abstract:
... Tilapia lake virus (TiLV) is the main tilapia-infecting virus worldwide, causing serious economic losses to the tilapia aquaculture. However, there is no vaccine for this viral disease. Here, TiLV ORF10 (TiLV-ORF10) encoding a protein with abundant epitopes was cloned into the eukaryotic expression vector pcDNA3.1 as a vaccine candidate, and then used to evaluate the protective effects against TiL ...
DOI:
10.1016/j.aqrep.2022.101166

15. A high-resolution melting assay to differentiate a peste des petits ruminants virus vaccine strain from field isolates in Turkey

Author:
Mustafa Emin Oz; Emrah Torlak
Source:
Archives of virology 2022 v.167 no.3 pp. 941-946
ISSN:
0304-8608
Subject:
vaccination; virology; viruses; Nigeria
Abstract:
... Peste des petits ruminants (PPR) mostly affects small ruminants. Vaccination with attenuated vaccines derived from PPR virus (PPRV) provides successful protection against the disease. However, current molecular methods are unable to distinguish vaccine strains from field strains. In this study, we used an EvaGreen-based high-resolution melting (HRM) assay to differentiate a PPRV vaccine strain (Ni ...
DOI:
10.1007/s00705-022-05386-x

16. A highly pathogenic Marek’s disease virus isolate from chickens immunized with a bivalent vaccine in China

Author:
Huimin Li; Zengxu Ge; Qiong Luo; Qiang Fu; Ruiai Chen
Source:
Archives of virology 2022 v.167 no.3 pp. 861-870
ISSN:
0304-8608
Subject:
flocks; genetic variation; morbidity; mortality; pathogens; vaccination; vaccines; virology; virulent strains; China
Abstract:
... Marek’s disease virus (MDV) is an important oncogenic poultry pathogen that can generally be controlled by vaccination. However, MDV infections still occur occasionally on vaccinated farms, possibly due to genetic variation among MDV strains or management-related issues. In this study, a novel MDV strain, designated LZ1309, was isolated from a poultry flock that had been vaccinated with the HVT an ...
DOI:
10.1007/s00705-021-05355-w

17. A live attenuated strain of HY9901ΔvscB provides protection against Vibrio alginolyticus in pearl gentian grouper (♀Epinephelus fuscoguttatus × ♂Epinephelus lanceolatu)

Author:
Huanying Pang; Yunsheng Chang; Hongwei Zheng; Huiming Tan; Shihui Zhou; Fuyuan Zeng; Rowena Hoare; Sean J. Monaghan; Na Wang; Yu Ding
Source:
Aquaculture 2022 v.546 pp. 737353
ISSN:
0044-8486
Subject:
Vibrio alginolyticus; Vibrio parahaemolyticus; amino acid sequences; antibiotic resistance; aquaculture; biofilm; doxycycline; gene expression regulation; grouper; kanamycin; live vaccines; liver; mutants; pathogens; phenotype; proteinases; sequence homology; spleen; transcriptome; vaccination; virulence
Abstract:
... Vibrio alginolyticus, a bacterial pathogen in fish and humans, expresses a type III secretion system (T3SS) that is critical for pathogen virulence and disease development. In this study, the T3SS chaperone protein gene vscB was cloned from V. alginolyticus wild-type strain HY9901and the vscB gene has a length of 429 bp and encodes 142 amino acids. The amino acid sequence homology comparison resul ...
DOI:
10.1016/j.aquaculture.2021.737353

18. A multipathogen DNA vaccine elicits protective immune responses against two class A bioterrorism agents, anthrax and botulism

Author:
Na Young Kim; Won Rak Son; Min Hoon Lee; Hong Seok Choi; Jun Young Choi; Young Jo Song; Chi Ho Yu; Dong Hyun Song; Gyeung Haeng Hur; Seong Tae Jeong; Sung Youl Hong; Young Kee Shin; Sungho Shin
Source:
Applied microbiology and biotechnology 2022 v.106 no.4 pp. 1531-1542
ISSN:
0175-7598
Subject:
Bacillus anthracis; Clostridium botulinum; anthrax; biotechnology; bioterrorism; blood serum; botulinum toxin; botulism; disease outbreaks; genes; microbiology; public health; recombinant vaccines; vaccination; vaccine development
Abstract:
... The potential use of biological agents has become a major public health concern worldwide. According to the CDC classification, Bacillus anthracis and Clostridium botulinum, the bacterial pathogens that cause anthrax and botulism, respectively, are considered to be the most dangerous potential biological agents. Currently, there is no licensed vaccine that is well suited for mass immunization in t ...
DOI:
10.1007/s00253-022-11812-6

19. A network biology approach to identify crucial host targets for COVID-19

Author:
Ranjan Kumar Barman; Anirban Mukhopadhyay; Ujjwal Maulik; Santasabuj Das
Source:
Methods 2022 pp. -
ISSN:
1046-2023
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; adenosine monophosphate; death; drugs; guanosine triphosphate; humans; mass spectrometry; pandemic; protein-protein interactions; vaccination
Abstract:
... The ongoing global pandemic of COVID-19, caused by SARS-CoV-2 has killed more than 5.9 million individuals out of ∼43 million confirmed infections. At present, several parts of the world are encountering the 3rd wave. Mass vaccination has been started in several countries but they are less likely to be broadly available for the current pandemic, repurposing of the existing drugs has drawn highest ...
DOI:
10.1016/j.ymeth.2022.03.016

20. A phase 1/2 randomised placebo-controlled study of the COVID-19 vaccine mRNA-1273 in healthy Japanese adults: An interim report

Author:
Taisei Masuda; Kyoko Murakami; Kenkichi Sugiura; Sho Sakui; Ron Philip Schuring; Mitsuhiro Mori
Source:
Vaccine 2022 v.40 no.13 pp. 2044-2052
ISSN:
0264-410X
Subject:
COVID-19 infection; Japan; Severe acute respiratory syndrome coronavirus 2; biomedical research; confidence interval; immunogenicity; injection site; pain; pharmaceutical industry; placebos; protein binding; research and development; risk; seroconversion; vaccination; vaccines
Abstract:
... The mRNA vaccine, mRNA-1273/TAK-919, encodes the prefusion-stabilised spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We report interim results of the first study evaluating safety and immunogenicity of mRNA-1273 in healthy Japanese participants. This phase 1/2, randomised, observer-blind, placebo-controlled trial, conducted in Japan (two sites), enrolled healthy adu ...
DOI:
10.1016/j.vaccine.2022.02.030

21. A phase 2 randomized controlled dose-ranging trial of recombinant pertussis booster vaccines containing genetically inactivated pertussis toxin in women of childbearing age

Author:
Kulkanya Chokephaibulkit; Thanyawee Puthanakit; Niranjan Bhat; Souad Mansouri; Yuxiao Tang; Keswadee Lapphra; Supattra Rungmaitree; Suvaporn Anugulruengkitt; Watsamon Jantarabenjakul; Indah Andi-Lolo; Renee Holt; Librada Fortuna; Chawanee Kerdsomboon; Pailinrut Chinwangso; Ladda Suwitruengrit; Anita H.J. van den Biggelaar; Simonetta Viviani; Hong Thai Pham; Bruce L. Innis
Source:
Vaccine 2022 v.40 no.15 pp. 2352-2361
ISSN:
0264-410X
Subject:
blood serum; clinical trials; confidence interval; diphtheria; immunogenicity; immunoglobulin G; injection site; pertussis toxin; tetanus; vaccination; vaccines; Thailand
Abstract:
... A phase 2 randomized-controlled safety and immunogenicity trial evaluating different doses of recombinant acellular pertussis vaccine containing genetically-inactivated pertussis toxin (PTgₑₙ) was conducted in women of childbearing age in Thailand to identify formulations to advance to a trial in pregnant women. A total of 250 women were randomized 1:1:1:1:1 to receive one dose of one of three inv ...
DOI:
10.1016/j.vaccine.2021.10.076

22. A phase 3 study to assess the immunogenicity, safety, and tolerability of MenB-FHbp administered as a 2-dose schedule in adolescents and young adults

Author:
Daniel Drazan; Hanna Czajka; Jason D. Maguire; Jean-Louis Pregaldien; Roger Maansson; Robert O'Neill; Annaliesa S Anderson; Paul Balmer; Johannes Beeslaar; John L Perez
Source:
Vaccine 2022 v.40 no.2 pp. 351-358
ISSN:
0264-410X
Subject:
antibodies; blood serum; complement; humans; immunogenicity; serotypes; vaccination; vaccines
Abstract:
... The MenB-FHbp vaccine is licensed to prevent meningococcal serogroup B disease on either a 2-dose (0, 6 months) or 3-dose (0, 1–2, 6 months) series. This phase 3 study further assessed the immunogenicity and safety of the 2-dose MenB-FHbp schedule.Subjects 10–25 years of age received MenB-FHbp (months 0, 6) and the quadrivalent meningococcal conjugate vaccine MenACWY-CRM (month 0). Primary immunog ...
DOI:
10.1016/j.vaccine.2021.11.053

23. A phase 3 trial of safety, tolerability, and immunogenicity of V114, 15-valent pneumococcal conjugate vaccine, compared with 13-valent pneumococcal conjugate vaccine in adults 50 years of age and older (PNEU-AGE)

Author:
Heather L. Platt; Jose F. Cardona; Miwa Haranaka; Howard I. Schwartz; Silvia Narejos Perez; Anthony Dowell; Chih-Jen Chang; Ron Dagan; Gretchen M. Tamms; Tina Sterling; Leslie Morgan; Yaru Shi; Alison Pedley; Luwy K. Musey; Ulrike K. Buchwald
Source:
Vaccine 2022 v.40 no.1 pp. 162-172
ISSN:
0264-410X
Subject:
Streptococcus pneumoniae; burden of disease; immunogenicity; immunoglobulin G; injection site; pain; serotypes; vaccination; vaccines
Abstract:
... Pneumococcal conjugate vaccines (PCVs) have greatly reduced the incidence of pneumococcal disease, yet unmet medical need remains due to increased disease caused by non-vaccine serotypes (STs). V114 (VAXNEUVANCEᵀᴹ, Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., Kenilworth, NJ, USA) is a 15-valent PCV containing 13 serotypes in licensed PCV13 and 2 additional serotypes (22F, 33F) whi ...
DOI:
10.1016/j.vaccine.2021.08.049

24. A place for neutrophils in the beneficial pathogen-agnostic effects of the BCG vaccine

Author:
Byron Brook; Frederick Schaltz-Buchholzer; Rym Ben-Othman; Tobias Kollmann; Nelly Amenyogbe
Source:
Vaccine 2022 v.40 no.11 pp. 1534-1539
ISSN:
0264-410X
Subject:
BCG vaccine; childhood; epigenetics; humans; immunity; malaria; monocytes; mortality; neonates; neutrophils; risk reduction; tuberculosis; vaccination
Abstract:
... The BCG vaccine has long been recognized for reducing the risk to suffer from infectious diseases unrelated to its target disease, tuberculosis. Evidence from human trials demonstrate substantial reductions in all-cause mortality, especially in the first week of life. Observational studies have identified an association between BCG vaccination and reduced risk of respiratory infectious disease and ...
DOI:
10.1016/j.vaccine.2021.03.092

25. A protein vaccine with Alum/c-GAMP/poly(I:C) rapidly boosts robust immunity against SARS-CoV-2 and variants of concern

Author:
Ru-Yan Zhang; Xu-Guang Yin; Shi-Hao Zhou; Hai-Wei Zhang; Jie Lu; Chen-Bin He; Jian Wang; Yu Wen; Yu-Ting Li; Yan-Ling Liu; Ran-Ran Feng; Dong Ding; Hua-Wei Wei; Rui Gong; Guang-Fu Yang; Jun Guo
Source:
Chemical communications 2022 v.58 no.24 pp. 3925-3928
ISSN:
1364-548X
Subject:
COVID-19 infection; Pseudovirus; Severe acute respiratory syndrome coronavirus 2; adjuvants; agonists; alum; aluminum; cell-mediated immunity; gels; immune response; immunogenicity; synergism; vaccination; vaccines; viruses
Abstract:
... Adjuvants are important components in vaccines to increase the immunogenicity of proteins and induce optimal immunity. In this study, we designed a novel ternary adjuvant system Alum + c-GAMP + poly(I:C) with STING agonist 3,3′-c-GAMP (c-GAMP) and TLR3 agonist poly(I:C) co-adsorbed on the conventional adjuvant aluminum gel (Alum), and further constructed an S1 protein vaccine. Two doses of vaccina ...
DOI:
10.1039/d2cc00271j

26. A randomized clinical trial of a booster dose with low versus standard dose of AZD1222 in adult after 2 doses of inactivated vaccines

Author:
Sira Nanthapisal; Thanyawee Puthanakit; Peera Jaru-Ampornpan; Rapisa Nantanee; Pimpayao Sodsai; Orawan Himananto; Jiratchaya Sophonphan; Pintip Suchartlikitwong; Narin Hiransuthikul; Pornpimon Angkasekwinai; Auchara Tangsathapornpong; Nattiya Hirankarn; on behalf of the study team
Source:
Vaccine 2022 v.40 no.18 pp. 2551-2560
ISSN:
0264-410X
Subject:
Severe acute respiratory syndrome coronavirus 2; adults; fever; geometry; immunogenicity; neutralization tests; randomized clinical trials; vaccination
Abstract:
... Immunogenicity of inactivated SARS-CoV-2 vaccine has waning antibody over time. With the emergence of the SARS-CoV-2 delta variant, which requires higher neutralizing antibody to prevent infection, a booster dose is needed. To evaluate immunogenicity and reactogenicity of standard- versus low-dose ChAdOx1 nCoV-19 vaccine booster after CoronaVac in healthy adults. A double-blinded, randomized, cont ...
DOI:
10.1016/j.vaccine.2022.03.036

27. A randomized controlled trial of antibody response to 2019–20 cell-based inactivated and egg-based live attenuated influenza vaccines in children and young adults

Author:
Katherine V. Williams; Bo Zhai; John F. Alcorn; Mary Patricia Nowalk; Min Z. Levine; Sara S. Kim; Brendan Flannery; Krissy Moehling Geffel; Amanda Jaber Merranko; Jennifer P. Nagg; Mark Collins; Michael Susick; Karen S. Clarke; Richard K. Zimmerman; Judith M. Martin
Source:
Vaccine 2022 v.40 no.5 pp. 780-788
ISSN:
0264-410X
Subject:
antibody formation; blood; cell culture; eggs; hemagglutination; influenza; influenza vaccines; live vaccines; randomized clinical trials; vaccination
Abstract:
... Hemagglutination inhibition (HAI) titers to the live-attenuated influenza vaccine (LAIV4) are typically lower than its counterpart egg-based inactivated influenza vaccines (IIV). Similar comparisons have not been made between LAIV4 and the 4-strain, cell-culture inactivated influenza vaccine (ccIIV4). We compared healthy children’s and young adults’ HAI titers against the 2019–2020 LAIV4 and ccIIV ...
DOI:
10.1016/j.vaccine.2021.12.034

28. A randomized, double-blind phase I clinical trial of two recombinant dimeric RBD COVID-19 vaccine candidates: Safety, reactogenicity and immunogenicity

Author:
Sonia Pérez-Rodríguez; Meiby de la Caridad Rodríguez-González; Rolando Ochoa-Azze; Yanet Climent-Ruiz; Carlos Alberto González-Delgado; Beatriz Paredes-Moreno; Carmen Valenzuela-Silva; Laura Rodríguez-Noda; Rocmira Perez-Nicado; Raúl González-Mugica; Marisel Martínez-Pérez; Belinda Sánchez-Ramírez; Tays Hernández-García; Alina Díaz-Machado; Maura Tamayo-Rodríguez; Alis Martín-Trujillo; Jorman Rubino-Moreno; Anamary Suárez-Batista; Marta Dubed-Echevarría; María Teresa Pérez-Guevara; Mayté Amoroto-Roig; Yanet Chappi-Estévez; Gretchen Bergado-Báez; Franciscary Pi-Estopiñán; Guang-Wu Chen; Yury Valdés-Balbín; Dagmar García-Rivera; Vicente Verez-Bencomo
Source:
Vaccine 2022 v.40 no.13 pp. 2068-2075
ISSN:
0264-410X
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; adjuvants; blood serum; clinical trials; humoral immunity; immunogenicity; neutralization tests; seroconversion; toxicology; vaccination; vaccines
Abstract:
... The Receptor Binding Domain (RBD) of the SARS-CoV-2 spike protein is the target for many COVID-19 vaccines. Here we report results for phase I clinical trial of two COVID-19 vaccine candidates based on recombinant dimeric RBD (d-RBD). We performed a randomized, double-blind, phase I clinical trial in the National Centre of Toxicology in Havana. Sixty Cuban volunteers aged 19–59 years were randomiz ...
DOI:
10.1016/j.vaccine.2022.02.029

29. A recombinant Leishmania amastigote-specific protein, rLiHyG, with adjuvants, protects against infection with Leishmania infantum

Author:
Amanda S. Machado; Daniela P. Lage; Danniele L. Vale; Camila S. Freitas; Flávia P. Linhares; Jamille M.O. Cardoso; Isabela A.G. Pereira; Fernanda F. Ramos; Grasiele S.V. Tavares; Fernanda Ludolf; João A. Oliveira-da-Silva; Raquel S. Bandeira; Aratti C. Simões; Mariana C. Duarte; Jamil S. Oliveira; Myron Christodoulides; Miguel A. Chávez-Fumagalli; Bruno M. Roatt; Vívian T. Martins; Eduardo A.F. Coelho
Source:
Acta tropica 2022 v.230 pp. 106412
ISSN:
0001-706X
Subject:
Leishmania infantum; adjuvants; control methods; hepatotoxicity; immunoglobulin G; interleukin-12; lymph; micelles; parasite load; parasites; polymers; recombinant proteins; saponins; spleen; vaccination; vaccines; visceral leishmaniasis
Abstract:
... Vaccination against visceral leishmaniasis (VL) should be considered as a control measure to protect against disease, and amastigote-specific proteins could help to develop such vaccines, since this parasite form is in contact with the host immune system during the active disease. In this study, a Leishmania amastigote-specific protein, LiHyG, was evaluated as recombinant protein (rLiHyG) as vacci ...
DOI:
10.1016/j.actatropica.2022.106412

30. A retrospective analysis of social media posts pertaining to COVID-19 vaccination side effects

Author:
Max-Philipp Lentzen; Viola Huebenthal; Rolf Kaiser; Matthias Kreppel; Joachim E. Zoeller; Matthias Zirk
Source:
Vaccine 2022 v.40 no.1 pp. 43-51
ISSN:
0264-410X
Subject:
COVID-19 infection; retrospective studies; vaccination; vaccines
Abstract:
... With an uprising influence of social media platforms like Twitter and Instagram a multitude of worldwide accessible information is available. Since the beginning of COVID-19 pandemic the exchange of medical information about several topics related to this infectious disease and its vaccination has increased rapidly. The purpose of this investigation was to assess the content associated with COVID- ...
DOI:
10.1016/j.vaccine.2021.11.052

31. A review of epidemiological models of Clostridioides difficile transmission and control (2009–2021)

Author:
Cristina Lanzas; Manuel Jara; Rachel Tucker; Savannah Curtis; CDC Modeling Infectious Diseases in Healthcare Program (MinD)
Source:
Anaerobe 2022 pp. 102541
ISSN:
1075-9964
Subject:
Clostridium difficile; bibliometric analysis; diarrhea; disease control; health services; vaccination
Abstract:
... Clostridioides difficile is the leading cause of infectious diarrhea and one of the most common healthcare-acquired infections worldwide. We performed a systematic search and a bibliometric analysis of mathematical and computational models for Clostridioides difficile transmission. We identified 33 publications from 2009 to 2021. Models have underscored the importance of asymptomatic colonized pat ...
DOI:
10.1016/j.anaerobe.2022.102541

32. A self-amplifying RNA vaccine protects against SARS-CoV-2 (D614G) and Alpha variant of concern (B.1.1.7) in a transmission-challenge hamster model

Author:
Rebecca Frise; Laury Baillon; Jie Zhou; Ruthiran Kugathasan; Thomas P. Peacock; Jonathan C. Brown; Karnyart Samnuan; Paul F. McKay; Robin J. Shattock; Wendy S. Barclay
Source:
Vaccine 2022 v.40 no.20 pp. 2848-2855
ISSN:
0264-410X
Subject:
Mesocricetus auratus; RNA; Severe acute respiratory syndrome coronavirus 2; animal models; disease severity; humans; nose; summer; vaccination; vaccines; viruses
Abstract:
... Vaccines for SARS-CoV-2 have been hugely successful in alleviating hospitalization and deaths caused by the newly emerged coronavirus that is the cause of COVID. However, although the parentally administered vaccines are very effective at reducing severe disease, they do not induce sterilizing immunity. As the virus continues to circulate around the globe, it is still not clear how long protection ...
DOI:
10.1016/j.vaccine.2022.03.064

33. A severe case of Trichophyton rubrum-caused dermatomycosis exacerbated after COVID-19 vaccination that had to be differentiated from pustular psoriasis

Author:
Yuta Norimatsu; Yurie Norimatsu
Source:
Medical mycology case reports 2022 v.36 pp. 19-22
ISSN:
2211-7539
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; Trichophyton rubrum; biopsy; dermatomycoses; luliconazole; mycology; patients; psoriasis; tissue culture; vaccination
Abstract:
... We present a case of deep dermatomycosis caused by Trichophyton rubrum that developed after administration of SARS-CoV-2 BNT162b2 vaccination. A 75-year-old man was vaccinated with SARS-CoV-2 on day 0 and day 23. From day 25, pustules began to appear. A skin biopsy was performed. Tissue culture revealed the presence of Trichophyton rubrum. The patient was treated with topical luliconazole and 100 ...
DOI:
10.1016/j.mmcr.2022.03.001

34. A simple method for purification of epsilon toxin of Clostridium perfringens type D for serum neutralization assay

Author:
Lida Abdolmohammadi Khiav; Anahita Emadi; Azadeh Zahmatkesh
Source:
Journal of microbiological methods 2022 v.193 pp. 106395
ISSN:
0167-7012
Subject:
ammonium sulfate; blood serum; cell culture; chromatography; cost effectiveness; disease prevention; enterotoxemia; lethal dose; neutralization; neutralization tests; phosphates; polyacrylamide gel electrophoresis; purification methods; small ruminants; toxins; vaccination; vaccines
Abstract:
... Enterotoxaemia, a disease that affects domestic ruminants, is caused by the epsilon toxin of Clostridium perfringens type D and B. Control and prophylaxis are based on systemic vaccination of small ruminant herds with epsilon toxoid. Purified epsilon toxin is an essential material for vaccine evaluation. It is also necessary for diagnosis of enterotoxaemia disease in the field by in vitro tests in ...
DOI:
10.1016/j.mimet.2021.106395

35. A simple, robust flow cytometry-based whole blood assay for investigating sex differential interferon alpha production by plasmacytoid dendritic cells

Author:
Oliver Sampson; Nicholas Lim; Jemima White; Vinicius Vieira; Henrik Kløverpris; Emily Adland; Chris Conlon; Donal Skelly; Lucy Jones; Lizzie Stafford; Anni Jamsen; Ellie Barnes; Susie Dunachie; John Frater; Paul Klenerman; Marcus Altfeld; Philip Goulder
Source:
Journal of immunological methods 2022 v.504 pp. 113263
ISSN:
0022-1759
Subject:
blood; cryopreservation; cytokines; immune response; innate immunity; vaccination
Abstract:
... Central to sex differences observed in outcome from infection and vaccination is the innate immune response, and specifically production of type I interferons by plasmacytoid dendtiric cells (pDCs), the main producers of IFN-α. Evaluation of IFN-α production by pDCs is therefore critical for studies of innate immune function. However, reliable measurement of pDC IFN-α is hampered by reduced cell y ...
DOI:
10.1016/j.jim.2022.113263

36. A solid-in-oil-in-water emulsion: An adjuvant-based immune-carrier enhances vaccine effect

Author:
Yoshiro Tahara; Riko Mizuno; Tomoki Nishimura; Sada-atsu Mukai; Rie Wakabayashi; Noriho Kamiya; Kazunari Akiyoshi; Masahiro Goto
Source:
Biomaterials 2022 v.282 pp. 121385
ISSN:
0142-9612
Subject:
adjuvants; antigen presentation; antigens; biocompatible materials; cytotoxicity; emulsions; humans; immunogenicity; oils; small-angle X-ray scattering; vaccination; vaccines
Abstract:
... The biomaterial-based immunoengineering has become one of the most attractive research fields in the last decade. In the present study, a solid-in-oil-in-water (S/O/W) emulsion encapsulating antigen in the oil phase of an oil-in-water (O/W) emulsion was prepared as a novel vaccine carrier consisting of similar materials to the emulsion adjuvant of which the safety, immunogenicity and vaccination e ...
DOI:
10.1016/j.biomaterials.2022.121385

37. A spatiotemporally resolved infection risk model for airborne transmission of COVID-19 variants in indoor spaces

Author:
Xiangdong Li; Daniel Lester; Gary Rosengarten; Craig Aboltins; Milan Patel; Ivan Cole
Source:
Science of the total environment 2022 v.812 pp. 152592
ISSN:
0048-9697
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; aerosols; air flow; airborne transmission; environment; filtration; health services; hospitals; humans; mechanization; models; prediction; risk; risk estimate; vaccination; viruses
Abstract:
... The classic Wells-Riley model is widely used for estimation of the transmission risk of airborne pathogens in indoor spaces. However, the predictive capability of this zero-dimensional model is limited as it does not resolve the highly heterogeneous spatiotemporal distribution of airborne pathogens, and the infection risk is poorly quantified for many pathogens. In this study we address these shor ...
DOI:
10.1016/j.scitotenv.2021.152592

38. A survey of veterinarians' practices, recommendations and perceptions associated with the prevention of tetanus in horses in Australia

Author:
ST Dennis; CM El Hage; VJ Brookes
Source:
Australian veterinary journal 2022 v.100 no.4 pp. 181-186
ISSN:
0005-0423
Subject:
antitoxins; body weight; disease prevention; horses; mortality; surveys; tetanus; vaccination; Australia
Abstract:
... OBJECTIVE: Identify veterinarians' practices, recommendations and perceptions when preventing tetanus in horses in Australia. METHODS: Graduated members of Equine Veterinarians Australia participated in an online survey about the prevention of tetanus in horses in Australia. RESULTS: Of 77 respondents (response rate ~ 8%), 50 (65%) reported that they had attended collectively 145–152 cases of teta ...
DOI:
10.1111/avj.13144

39. A two-dose optimum for recombinant S1 protein-based COVID-19 vaccination

Author:
Zhidong Hu; Jian-Ping Chen; Jin-Chuan Xu; Zhen-Yan Chen; Rong Qu; Ling Zhang; Wenrong Yao; Juan Wu; Heng Yang; Douglas B. Lowrie; Yong Liu; Xiao-Yong Fan
Source:
Virology 2022 v.566 pp. 56-59
ISSN:
0042-6822
Subject:
COVID-19 infection; immunogenicity; immunoglobulin G; protein subunits; public health; recombinant proteins; saponins; vaccination; vaccine adjuvants; virology
Abstract:
... Recombinant protein subunit vaccination is considered to be a safe, fast and reliable technique when combating emerging and re-emerging diseases such as coronavirus disease 2019 (COVID-19). Typically, such subunit vaccines require the addition of adjuvants to attain adequate immunogenicity. AS01, which contains adjuvants MPL and saponin QS21, is a liposome-based vaccine adjuvant system that is one ...
DOI:
10.1016/j.virol.2021.11.011

40. Acaricide resistance in livestock ticks infesting cattle in Africa: Current status and potential mitigation strategies

Author:
Naftaly W. Githaka; Esther G. Kanduma; Barbara Wieland; Mohamed A. Darghouth; Richard P. Bishop
Source:
Current research in parasitology and vector-borne diseases 2022 pp. 100090
ISSN:
2667-114X
Subject:
acaricide resistance; acaricides; amidines; cattle; education; land management; larvae; markets; organophosphorus compounds; parasitology; pyrethrins; research; tick control; ticks; vaccination; Australia; Latin America; South Africa; Uganda; Western Africa
Abstract:
... In many African countries, tick control has recently been the responsibility of resource-poor farmers rather than central government veterinary departments. This has led to an increase in acaricide resistance, threatening the welfare of livestock farmers in sub-Saharan Africa. Resistance has evolved to the three classes of acaricides used most extensively in the continent, namely fourth-generation ...
DOI:
10.1016/j.crpvbd.2022.100090

41. Acceptance and application of a broad population health perspective when evaluating vaccine

Author:
Ulf Persson; Sara Olofsson; Rikard Althin; Andreas Palmborg; Ann-Charlotte Dorange
Source:
Vaccine 2022 v.40 no.24 pp. 3395-3401
ISSN:
0264-410X
Subject:
COVID-19 infection; caregivers; economic evaluation; herds; patients; stakeholders; vaccination; vaccine development; vaccines; Sweden
Abstract:
... The traditional health economic analysis is limited to estimating the impact on the treated patient. As vaccines are usually aimed at preventing infectious diseases, they may be associated with additional values for the non-treated wider population. Although there are valid reasons for treating vaccines differently, and a wide support for a broader perspective in the literature (i.e., beyond the n ...
DOI:
10.1016/j.vaccine.2022.04.009

42. Accuracy of interferon gamma release assays for the COVID-19 immunity assessment

Author:
Francis Stieber; Nadia Allen; Kara Carpenter; Jenny Howard; Riccardo Alagna; Davide Manissero; Vladyslav Nikolayevskyy
Source:
Journal of virological methods 2022 v.302 pp. 114472
ISSN:
0166-0934
Subject:
COVID-19 infection; T-lymphocytes; absorbance; good laboratory practices; immunity; interferon-gamma; mitogens; vaccination
Abstract:
... Emerging evidence suggests that T-cells play a significant role in COVID-19 immunity both in the context of natural infection and vaccination. Easy to use IGRA assays including QFN SARS are considered attractive alternatives to more “traditional” but laborious methods for detection of SARS-CoV-2-specific T-cell responses. In our Letter we are proposing explanations to an apparently lower than expe ...
DOI:
10.1016/j.jviromet.2022.114472

43. Acute unsolicited adverse events following BNT162b2 vaccine in Saudi Arabia, a real-world data

Author:
Abdulellah M. Almohaya; Haya Alsubie; Bader Alqarni; Bashayer Alzayad; Ali Alghar; Khalid Alshahrani; Mazin Barry
Source:
Vaccine 2022 v.40 no.3 pp. 477-482
ISSN:
0264-410X
Subject:
COVID-19 infection; anaphylaxis; death; demographic statistics; females; headache; nausea; statistical analysis; syncope; vaccination; vaccines; Saudi Arabia
Abstract:
... Acute adverse events and anaphylaxis were reported after the administration of coronavirus disease (COVID-19) mRNA vaccines. We aim to explore the nature and outcome of adverse events following BNT162B2 vaccine in a community vaccination center, Riyadh, Saudi Arabia.Within 30 min post vaccination, all acute adverse events (AAEs) that occurred before March 31st, 2021, and in people older than 16 ye ...
DOI:
10.1016/j.vaccine.2021.12.001

44. Adolescents’ attitudes to the COVID-19 vaccination

Author:
W.H.S. Wong; D. Leung; G.T. Chua; J.S.R. Duque; S. Peare; H.K. So; S.M. Chan; M.Y.W. Kwan; P. Ip; Y.L. Lau
Source:
Vaccine 2022 v.40 no.7 pp. 967-969
ISSN:
0264-410X
Subject:
COVID-19 infection; herd immunity; influenza vaccines; models; risk; surveys; vaccination; China
Abstract:
... Vaccines against COVID-19 are now available for adolescents in Hong Kong but vaccine hesitancy is a major barrier to herd immunity. This survey study explores Hong Kong adolescents’ attitudes towards the COVID-19 vaccination. 2609 adolescents from across Hong Kong completed an online survey focused on the intent to vaccinate and the reasons for their choice. 39% of adolescents intended to take the ...
DOI:
10.1016/j.vaccine.2022.01.010

45. Adverse effect of vaccination in xenogeneic animals

Author:
Salma A. Shoulah; Said M. Elshafae; Mohamed M.S. Gaballa; Maha A. Moussa; Abdelfattah Selim; Kotb Attia; Muneera D.F. AlKahtani; Fatima M. Albohairy
Source:
Microbial pathogenesis 2022 v.166 pp. 105541
ISSN:
0882-4010
Subject:
Lumpy skin disease virus; Sheeppox virus; adverse effects; atomization; cattle; hematopoiesis; histopathology; immunogenicity; live vaccines; lumpy skin disease; males; megakaryocytes; milk production; mortality; pathogenesis; pathogenicity; vaccination
Abstract:
... Lumpy skin disease (LSD) is a devastating, emerging viral disease of cattle. It causes significant economic losses due to trade restrictions that are placed on infected animals and the biological effects of the disease: infertility, dramatic loss in milk production, induction of abortion and mortality. It is caused by lumpy skin disease virus (LSDV), which belongs to the Poxviridae family. Vaccina ...
DOI:
10.1016/j.micpath.2022.105541

46. Adverse event of Sinovac Coronavirus vaccine: Deafness

Author:
Hai Zhao; Yongtuan Li; Zhiyuan Wang
Source:
Vaccine 2022 v.40 no.3 pp. 521-523
ISSN:
0264-410X
Subject:
COVID-19 infection; Orthocoronavirinae; deafness; protective effect; vaccination; vaccines
Abstract:
... COVID-19 has spread worldwide and is one of the most threatening infectious diseases in the world. Vaccination is known as an effective method to protect susceptible populations against such diseases. The Coronavirus vaccine developed by Sinovac has been shown to have a high protective effect, but it also has potential adverse events. For example, our department saw two patients with reported case ...
DOI:
10.1016/j.vaccine.2021.11.091

47. Agreement between In-Clinics and Virus Neutralization Tests in Detecting Antibodies against Canine Distemper Virus (CDV)

Author:
Sara Meazzi; Joel Filipe; Alessandra Fiore; Santina Di Bella; Francesco Mira; Paola Dall’Ara
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Canine morbillivirus; antibodies; dogs; neutralization tests; vaccination; vaccines
Abstract:
... Core vaccinations and specific antibody titer evaluations are strongly recommended worldwide by all the vaccination guidelines. Virus neutralization (VN) is considered the gold standard for measuring antibody titer against canine distemper virus, but it is complex and time consuming, and the use of in-clinics tests would allow to obtain quicker results. The aim of this study was to evaluate the ag ...
DOI:
10.3390/v14030517

48. Alternative SARS-CoV-2 detection protocol from self-collected saliva for mass diagnosis and epidemiological studies in low-incoming regions

Author:
Luana Prado Rolim de Oliveira; Aline Diniz Cabral; Andreia Moreira dos Santos Carmo; Adriana Feliciano Duran; Diego Marin Fermino; Glaucia Raquel Luciano Veiga; Beatriz da Costa Aguiar Alves; Carla Moreira Santana; Felipe Baena Garcia; Edmar Silva Santos; Felipe Trovalim Jordão; Andressa Moreira Siqueira; Ivana Barros de Campos; Daniela Rodrigues Colpas; Fernanda Nascimento Almeida; Fernando Luiz Affonso Fonseca; Márcia Aparecida Sperança
Source:
Journal of virological methods 2022 v.300 pp. 114382
ISSN:
0166-0934
Subject:
RNA; Severe acute respiratory syndrome coronavirus 2; cotton; health services; human resources; hydrophilicity; nasopharynx; pandemic; reverse transcriptase polymerase chain reaction; saliva; vaccination; viruses
Abstract:
... Until mass vaccination befalls, control of the new betacoronavirus-associated severe acute respiratory syndrome pandemic (SARS-CoV-2) is based on decreasing virus circulation by social distancing and blocking transmission foci after diagnosis. Globally adopted SARS-CoV-2 diagnostic criteria embrace viral RNA detection by quantitative reverse-transcription polymerase chain reaction (qRT-PCR) on nas ...
DOI:
10.1016/j.jviromet.2021.114382

49. Aluminum nanoparticles deliver a dual-epitope peptide for enhanced anti-tumor immunotherapy

Author:
Shuting Bai; Hao Jiang; Yuanshuai Song; Yining Zhu; Ming Qin; Chunting He; Guangsheng Du; Xun Sun
Source:
Journal of controlled release 2022 v.344 pp. 134-146
ISSN:
0168-3659
Subject:
aluminum; amino acids; epitopes; humans; immune response; mice; neoplasms; peptides; vaccination
Abstract:
... Tumor peptide vaccines contain only key amino acid sequences of tumor neoantigens, and therefore can provide precise activation of immune responses. Recent research has found that short peptide vaccines restricted to MHC-I epitopes are insufficient to activate effective CD8⁺ T cell responses for tumor elimination, and assistance from CD4⁺ T cell immunity could significantly improve the therapeutic ...
DOI:
10.1016/j.jconrel.2022.02.027

50. An AAV vaccine targeting the RBD of the SARS-CoV-2 S protein induces effective neutralizing antibody titers in mice and canines

Author:
Fei Liu; Canbin Feng; Shiqi Xu; Qiang Wu; Jian Tang; Yan Chen; Ruisheng Xu; Fuliang Chen; Ni Gao; Zhengzheng Xu; Shihui Gu; Yang Lan; Haibo Zhou; Xinde Hu; Xiaojing Wang
Source:
Vaccine 2022 v.40 no.9 pp. 1208-1212
ISSN:
0264-410X
Subject:
COVID-19 infection; Pseudovirus; Severe acute respiratory syndrome coronavirus 2; pandemic; vaccination; vaccines
Abstract:
... The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in catastrophic damage worldwide. Accordingly, the development of powerful, safe, easily accessible vaccines with long-term effectiveness is understood as an urgently needed countermeasure against this ongoing pandemic. Guided by this strong promise of using AAVs, we ...
DOI:
10.1016/j.vaccine.2022.01.030

51. An Improved αvβ6-Receptor-Expressing Suspension Cell Line for Foot-and-Mouth Disease Vaccine Production

Author:
Yongjie Harvey; Ben Jackson; Brigid Veronica Carr; Kay Childs; Katy Moffat; Graham Freimanis; Chandana Tennakoon; Nicholas Juleff; Julian Seago
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Foot-and-mouth disease virus; cell culture; cell lines; food security; foot-and-mouth disease; growth models; hamsters; integrins; kidneys; livestock; strain differences; vaccination; vaccine development; vaccines; viruses; Asia; South America; Sub-Saharan Africa
Abstract:
... Foot-and-mouth disease (FMD) is endemic in large parts of sub-Saharan Africa, Asia and South America, where outbreaks in cloven-hooved livestock threaten food security and have severe economic impacts. Vaccination in endemic regions remains the most effective control strategy. Current FMD vaccines are produced from chemically inactivated foot-and-mouth disease virus (FMDV) grown in suspension cult ...
DOI:
10.3390/v14030621

52. An Update of Orthopoxvirus Molecular Evolution

Author:
Igor V. Babkin; Irina N. Babkina; Nina V. Tikunova
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
DNA; Monkeypox virus; Variola virus; genome; mutation rate; smallpox; vaccination; viruses
Abstract:
... Although variola virus (VARV) has been eradicated through widespread vaccination, other orthopoxviruses pathogenic for humans circulate in nature. Recently, new orthopoxviruses, including some able to infect humans, have been found and their complete genomes have been sequenced. Questions about the orthopoxvirus mutation rate and the emergence of new threats to humankind as a result of the evoluti ...
DOI:
10.3390/v14020388

53. An easy pipeline for one-step purification of SARS-CoV-2 nucleocapsid protein from insect cell suspension culture

Author:
Brenda R. de Camargo; Leonardo A. da Silva; Athos S. de Oliveira; Bergmann M. Ribeiro
Source:
Journal of virological methods 2022 v.299 pp. 114341
ISSN:
0166-0934
Subject:
Autographa californica multiple nucleopolyhedrovirus; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; affinity chromatography; cell suspension culture; genes; humans; imidazole; insects; nucleocapsid; nucleocapsid proteins; pH; protein content; seroconversion; vaccination
Abstract:
... The COVID-19 pandemic has demanded a range of biotechnological products for detection of SARS-CoV-2 variants and evaluation of human seroconversion after infection or vaccination. In this work, we describe an easy pipeline for expression of SARS-CoV-2 nucleocapsid (N) protein in insect cells followed by its purification via affinity chromatography. The N gene was cloned into the genome of Autograp ...
DOI:
10.1016/j.jviromet.2021.114341

54. An entropy-based study on mutational trajectory of SARS-CoV-2 in India

Author:
Daniele Santoni; Nimisha Ghosh; Indrajit Saha
Source:
Infection, genetics, and evolution 2022 v.97 pp. 105154
ISSN:
1567-1348
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; genome; infection; mutation; pandemic; vaccination; viruses; India
Abstract:
... The pandemic of COVID-19 has been haunting us for almost the past two years. Although, the vaccination drive is in full swing throughout the world, different mutations of the SARS-CoV-2 virus are making it very difficult to put an end to the pandemic. The second wave in India, one of the worst sufferers of this pandemic, can be mainly attributed to the Delta variant i.e. B.1.617.2. Thus, it is ver ...
DOI:
10.1016/j.meegid.2021.105154

55. An excitation wavelength-optimized, stable SERS biosensing nanoplatform for analyzing adenoviral and AstraZeneca COVID-19 vaccination efficacy status using tear samples of vaccinated individuals

Author:
Wansun Kim; Soogeun Kim; Jisang Han; Tae Gi Kim; Ayoung Bang; Hyung Woo Choi; Gyeong Eun Min; Jae-Ho Shin; Sang Woong Moon; Samjin Choi
Source:
Biosensors & bioelectronics 2022 v.204 pp. 114079
ISSN:
0956-5663
Subject:
Adenoviridae; COVID-19 infection; Pan troglodytes; biosensors; byproducts; detection limit; immunoglobulin G; keratoconjunctivitis; people; standard deviation; storage time; vaccination; vaccines
Abstract:
... We introduce a label-free surface-enhanced Raman scattering (SERS) biosensing platform equipped with metallic nanostructures that can identify the efficacy of Oxford-AstraZeneca (AZD1222) vaccine in vaccinated individuals using non-invasive tear samples. We confirmed the hypothesis that the tears of people who receive the AZD1222 vaccine may be similar to those of adenovirus epidemic keratoconjunc ...
DOI:
10.1016/j.bios.2022.114079

56. An inactivated vaccine based on artificial non-pathogenic fowl adenovirus 4 protects chickens against hepatitis-hydropericardium syndrome

Author:
Yu Zhang; Aijing Liu; Hongyu Cui; Xiaole Qi; Changjun Liu; Yanping Zhang; Kai Li; Li Gao; Xiaomei Wang; Qing Pan; Yulong Gao
Source:
Veterinary microbiology 2022 v.264 pp. 109285
ISSN:
0378-1135
Subject:
Fowl aviadenovirus C; biosafety; economic feasibility; genotype; immunogenicity; inactivated vaccines; lethal dose; microbiology; mortality; poultry industry; specific pathogen-free animals; vaccination; virulence
Abstract:
... Hepatitis-hydropericardium syndrome (HHS) in birds is mainly caused by virulent fowl adenovirus 4 (FAdV-4). A novel genotype, hypervirulent FAdV-4, emerged in 2015 with a high mortality rate ranging from 30 % to 100 % in chickens. Vaccination is an economically feasible method to control HHS. Although there have been various reports of inactivated vaccines from virulent wild-type FAdV-4 against HH ...
DOI:
10.1016/j.vetmic.2021.109285

57. An integrated in silico based subtractive genomics and reverse vaccinology approach for the identification of novel vaccine candidate and chimeric vaccine against XDR Salmonella typhi H58

Author:
Kanwal Khan; Khurshid Jalal; Reaz Uddin
Source:
Genomics 2022 v.114 no.2 pp. 110301
ISSN:
0888-7543
Subject:
Salmonella Typhi; computer simulation; drug resistance; epitopes; fever; genomics; human population; immune response; lipoproteins; nucleotide sequences; peptides; prioritization; proteome; recombinant vaccines; typhoid fever; vaccination; vaccine development; virulence
Abstract:
... Salmonella typhi is notorious for causing enteric fever which is also known as typhoid fever. It emerged as an extreme drug resistant strain that requires urgent attention to prevent its global spread. Statistically, about 11–17 million typhoid illnesses are reported worldwide annually. The only alternative approach for the control of this illness is proper vaccination. However, available typhoid ...
DOI:
10.1016/j.ygeno.2022.110301

58. Analysis of immune response induction mechanisms implicating the dose-sparing effect of transcutaneous immunization using a self-dissolving microneedle patch

Author:
Sayami Ito; Sachiko Hirobe; Ryo Yamashita; Arisa Sugiyama; Honoka Takeuchi; Ryosuke Eguchi; Junya Yoshida; Takayoshi Oyamada; Masashi Tachibana; Naoki Okada
Source:
Vaccine 2022 v.40 no.6 pp. 862-872
ISSN:
0264-410X
Subject:
B-lymphocytes; antibody formation; cell differentiation; cytokines; gene expression; lymph; transcription factors; vaccination; vaccines
Abstract:
... Transcutaneous immunization (TCI) is an effective vaccination method that is easier and less painful than the conventional injectable vaccination method. We previously developed self-dissolving microneedle patches (sdMN) and demonstrated that this TCI method has a high vaccination efficacy in mice and humans. To elucidate the mechanism of immune response induction, which is the basis for the effic ...
DOI:
10.1016/j.vaccine.2021.12.055

59. Analyzing the COVID-19 vaccination behavior based on epidemic model with awareness-information

Author:
Chao Zuo; Fenping Zhu; Zeyang Meng; Yuting Ling; Yuzhi Zheng; Xueke Zhao
Source:
Infection, genetics, and evolution 2022 v.98 pp. 105218
ISSN:
1567-1348
Subject:
COVID-19 infection; evolution; genetics; herd immunity; infection; information dissemination; mathematical models; morbidity; mortality; vaccination; vaccines; China
Abstract:
... The widespread use of effective COVID-19 vaccines could prevent substantial morbidity and mortality. Individual decision behavior about whether or not to be vaccinated plays an important role in achieving adequate vaccination coverage and herd immunity. This research proposes a new susceptible–vaccinated–exposed–infected–recovered with awareness-information (SEIR/V-AI) model to study the interacti ...
DOI:
10.1016/j.meegid.2022.105218

60. Analyzing the Use of Medicinal Herbs During the First Wave and Second Wave of COVID-19

Author:
Tanvi Singh; Arti Nigam; Rachna Kapila
Source:
Proceedings of the National Academy of Sciences, India, Section B: biological sciences 2022 v.92 no.1 pp. 219-222
ISSN:
0369-8211
Subject:
Ayurvedic medicine; COVID-19 infection; Internet; Orthocoronavirinae; cuisine; immunity; people; surveys; vaccination; vaccines; India
Abstract:
... India has confronted the COVID-19 pandemic in 2020, in the form of first wave and again in first half of 2021 in the form of second wave. To combat the persistent transmission of the coronavirus, Indian Government has started the vaccination in the country since January 2021. The immunity conferred by the vaccine can be more effective with sound immune health. In India, medicinal herbs are preferr ...
DOI:
10.1007/s40011-021-01303-5

61. Analyzing the vaccination debate in social media data Pre- and Post-COVID-19 pandemic

Author:
Qingqing Chen; Andrew Crooks
Source:
International journal of applied earth observation and geoinformation 2022 v.110 pp. 102783
ISSN:
1569-8432
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; data collection; pandemic; space and time; spatial data; surveys; vaccination; vaccines; viruses
Abstract:
... The COVID-19 virus has caused and continues to cause unprecedented impacts on the life trajectories of millions of people globally. Recently, to combat the transmission of the virus, vaccination campaigns around the world have become prevalent. However, while many see such campaigns as positive (e.g., protecting lives), others see them as negative (e.g., the side effects that are not fully underst ...
DOI:
10.1016/j.jag.2022.102783

62. Anaphylaxis rates associated with COVID-19 vaccines are comparable to those of other vaccines

Author:
Helena C. Maltezou; Cleo Anastassopoulou; Sophia Hatziantoniou; Gregory A. Poland; Athanasios Tsakris
Source:
Vaccine 2022 v.40 no.2 pp. 183-186
ISSN:
0264-410X
Subject:
COVID-19 infection; anaphylaxis; humans; rabies; tick-borne encephalitis; vaccination; vaccines; Europe
Abstract:
... We retrieved data on 8940 anaphylaxis cases post-COVID-19 vaccination from the US Vaccine Adverse Event Reporting System and the European EudraVigilance from week 52/2020 through week 31/2021 and compared them with those of other vaccines. Overall, 837,830,000 COVID-19 vaccine doses were delivered in the US and Europe during the study period, for which the vaccine name was known. The mean anaphyla ...
DOI:
10.1016/j.vaccine.2021.11.066

63. Annual trends in adverse events following mumps vaccination in Japan: A retrospective study

Author:
Satoko Ohfuji; Takaaki Tanaka; Takashi Nakano; Tetsuo Kase; Kyoko Kondo; Wakaba Fukushima; Yoshio Hirota
Source:
Vaccine 2022 v.40 no.7 pp. 988-993
ISSN:
0264-410X
Subject:
Japan; encephalitis; meningitis; observational studies; retrospective studies; vaccination; vaccines
Abstract:
... In Japan, a monovalent mumps vaccine is provided on a voluntary basis. Due to public concerns over post-vaccination aseptic meningitis, the vaccination coverage is not high enough. The present study investigated the incidence of adverse events, including aseptic meningitis, after Torii strain–derived mumps vaccination. This retrospective, observational study used data collected by a vaccine manufa ...
DOI:
10.1016/j.vaccine.2022.01.008

64. Anti-RBD IgA and IgG Response and Transmission in Breast Milk of Anti-SARS-CoV-2 Vaccinated Mothers

Author:
Felicia Trofin; Eduard Vasile Nastase; Luminita Smaranda Iancu; Daniela Constantinescu; Corina Maria Cianga; Catalina Lunca; Ramona Gabriela Ursu; Petru Cianga; Olivia Simona Dorneanu
Source:
Pathogens 2022 v.11 no.3 pp. -
ISSN:
2076-0817
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibody formation; breast feeding; breast milk; children; enzyme-linked immunosorbent assay; milk; milk secretion; neonates; placenta; prospective studies; public health; vaccination; vaccines
Abstract:
... The appearance of the severe acute respiratory syndrome virus-2 (SARS-CoV-2) has had a significant impact on the balance of public health and social life. The data available so far show that newborns and young children do not develop severe forms of COVID-19, but a small proportion of them will still need hospitalization. Even though young children represent an important vector of the infection, v ...
DOI:
10.3390/pathogens11030286

65. Antibodies Targeting KSHV gH/gL Reveal Distinct Neutralization Mechanisms

Author:
Thomas Fricke; Anna K. Großkopf; Armin Ensser; Marija Backovic; Alexander S. Hahn
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
burden of disease; ferritin; glycoproteins; glycosylation; membrane fusion; mutants; neutralization; sarcoma; vaccination; vaccines; Sub-Saharan Africa
Abstract:
... Kaposi’s sarcoma herpesvirus (KSHV) is associated with a significant disease burden, in particular in Sub-Sahara Africa. A KSHV vaccine would be highly desirable, but the mechanisms underlying neutralizing antibody responses against KSHV remain largely unexplored. The complex made of glycoproteins H and L (gH/gL) activates gB for the fusion of viral and cellular membranes in all herpesviruses. KSH ...
DOI:
10.3390/v14030541

66. Antibody Response to SARS-CoV-2 Infection and Vaccination in COVID-19-naïve and Experienced Individuals

Author:
Susan L. Uprichard; Amornrat O’Brien; Monika Evdokimova; Cynthia L. Rowe; Cara Joyce; Matthew Hackbart; Yazmin E. Cruz-Pulido; Courtney A. Cohen; Michelle L. Rock; John M. Dye; Paul Kuehnert; Keersten M. Ricks; Marybeth Casper; Lori Linhart; Katrina Anderson; Laura Kirk; Jack A. Maggiore; Andrew S. Herbert; Nina M. Clark; Gail E. Reid; Susan C. Baker
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
Severe acute respiratory syndrome coronavirus 2; antibodies; antibody formation; antigens; durability; gender; neutralization; pandemic; vaccination; vaccines
Abstract:
... Understanding the magnitude of responses to vaccination during the ongoing SARS-CoV-2 pandemic is essential for ultimate mitigation of the disease. Here, we describe a cohort of 102 subjects (70 COVID-19-naïve, 32 COVID-19-experienced) who received two doses of one of the mRNA vaccines (BNT162b2 (Pfizer–BioNTech) and mRNA-1273 (Moderna)). We document that a single exposure to antigen via infection ...
DOI:
10.3390/v14020370

67. Antibody Responses after SARS-CoV-2 Vaccination in Patients with Liver Diseases

Author:
Athanasios-Dimitrios Bakasis; Kleopatra Bitzogli; Dimitrios Mouziouras; Abraham Pouliakis; Maria Roumpoutsou; Andreas V. Goules; Theodoros Androutsakos
Source:
Viruses 2022 v.14 no.2 pp. -
ISSN:
1999-4915
Subject:
Severe acute respiratory syndrome coronavirus 2; antibodies; elderly; immunogenicity; immunosuppression; liver; seroconversion; vaccination
Abstract:
... The novel mRNA-based vaccines against SARS-CoV-2 display encouraging safety and efficacy profiles. However, there is a paucity of data regarding their immunogenicity and safety in patients with liver diseases (PWLD), especially in those with cirrhosis. We prospectively assessed anti-SARS-CoV-2 S-spike IgG antibodies and neutralizing activity in fully vaccinated PWLD (n = 87) and controls (n = 40). ...
DOI:
10.3390/v14020207

68. Antibody Responses to a Reverse Genetics-Derived Bivalent Inactivated Equine Influenza Vaccine in Thoroughbred Horses

Author:
Minoru Ohta; Hiroshi Bannai; Yoshinori Kambayashi; Koji Tsujimura; Norihisa Tamura; Yohei Iwamoto; Ai Wakuno; Seiya Yamayoshi; Yoshihiro Kawaoka; Manabu Nemoto
Source:
Journal of equine veterinary science 2022 v.109 pp. 103860
ISSN:
0737-0806
Subject:
Thoroughbred; adults; antibodies; antibody formation; equine influenza; formalin; hemagglutination; hemagglutinins; horses; immunogenicity; influenza vaccines; reverse genetics; secondary immunization; sialidase; vaccination; veterinary medicine; viruses; Florida
Abstract:
... Updating vaccine strains is important to control equine influenza (EI). Previously, we reported that a monovalent inactivated EI vaccine derived from a virus generated by reverse genetics (RG) elicited immunogenicity in horses. In the present study, we compared antibody responses to a bivalent inactivated EI vaccine generated by RG and a commercially available bivalent inactivated EI (CO) vaccine ...
DOI:
10.1016/j.jevs.2021.103860

69. Antibody response after two doses of the BNT162b2 vaccine among healthcare workers of a Greek Covid 19 referral hospital: A prospective cohort study

Author:
Areti Tychala; Eleni Sidiropoulou; Sofia Dionysopoulou; Ioanna Gkeka; Georgios Meletis; Andreas Athanasiadis; Anastasia Boura-Theodorou; Chrysa Chantzi; Maria Koutri; Kali Makedou; Lemonia Skoura
Source:
Heliyon 2022 v.8 no.5 pp. e09438
ISSN:
2405-8440
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibody formation; cohort studies; health services; hospitals; humoral immunity; immunogenicity; vaccination; vaccines; Greece
Abstract:
... The global vaccination against SARS-CoV-2 has highlighted the need of assessing vaccines' immunogenicity against COVID-19. To evaluate humoral immunity induced by the BNT162b2 vaccine, we enrolled health care workers at AHEPA University Hospital of Thessaloniki, Greece to measure Anti-S SARS-CoV-2, anti-RBD SARS-CoV-2 and neutralizing antibodies. A total of 955 individuals with a median age of 50 ...
DOI:
10.1016/j.heliyon.2022.e09438

70. Antibody response to rabies pre-exposure vaccination among village health volunteers in a northern region of Thailand

Author:
Woottichai Khamduang; Sayamon Hongjaisee; Tippayathida Pothita; Natedao Kongyai; Sirithorn Surajinda; Wilaiwan Petsophonsakul; Sakorn Pornprasert
Source:
Preventive veterinary medicine 2022 v.199 pp. 105555
ISSN:
0167-5877
Subject:
antibodies; antibody formation; cost effectiveness; disease prevention; enzyme-linked immunosorbent assay; males; questionnaires; rabies; seroconversion; vaccination; veterinary medicine; villages; Thailand
Abstract:
... Rabies is a lethal, however the disease is preventable through vaccination either before or immediately after an exposure. This study aimed to provide a pre-exposure prophylaxis rabies immunization to village health volunteers (VHV) who provide rabies vaccination for pets and free-roaming dogs in their villages and evaluate the antibody level and adverse effects after vaccination. We also assessed ...
DOI:
10.1016/j.prevetmed.2021.105555

71. Antibody response to second dose of the BNT162b2 mRNA vaccine in the first 12 weeks in South Korea: A prospective longitudinal study

Author:
Hyun Jin Kim; Heon Jeong Yun; Jungok Kim; Sungmin Kym; Qute Choi
Source:
Vaccine 2022 v.40 no.3 pp. 437-443
ISSN:
0264-410X
Subject:
Severe acute respiratory syndrome coronavirus 2; antibody formation; hospitals; longitudinal studies; vaccination; vaccines; South Korea
Abstract:
... To characterise the antibody response for 12 weeks following second dose of the Pfizer/BioNTech BNT162b2 mRNA vaccine in hospital workers of a Korean general hospital.We measured the level of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) anti-receptor binding domain (anti-RBD) and neutralising antibodies every week in the first 4 weeks, and at weeks 8 and 12 following the second dos ...
DOI:
10.1016/j.vaccine.2021.12.012

72. Anticancer Vaccination with Immunogenic Micelles That Capture and Release Pristine CD8⁺ T-Cell Epitopes and Adjuvants

Author:
He Ren; Jiexin Li; Gengqi Liu; Yaping Sun; Xingyue Yang; Zhen Jiang; Jingyu Zhang; Jonathan F. Lovell; Yumiao Zhang
Source:
ACS applied materials & interfaces 2022 v.14 no.2 pp. 2510-2521
ISSN:
1944-8252
Subject:
aqueous solutions; cell-mediated immunity; composite polymers; disulfide bonds; epitopes; glutathione; humans; hydrophobicity; lungs; lymph; metastasis; mice; micelles; nanocarriers; neoplasm cells; papilloma; vaccination
Abstract:
... The development of nanocarriers capable of codelivering antigens and immune-activating adjuvants is an emerging area of research and is relevant for cancer vaccines that target induction of antigen-specific CD8⁺ T-cell responses. Here, we report a system for delivery of short peptide antigens to dendritic cells for strong cellular immune responses, based on block copolymers chemically modified wit ...
DOI:
10.1021/acsami.1c18117

73. Application of microneedle-based vaccines in biosecurity

Author:
Zhiying Jin; Baohua Zhao; Wei Wan; Yue Li; Xuexin Bai; Chenyi Hu; Jing Wang; Yanwei Li; Wenwen Xin; Lin Kang; Hao Yang; Jinglin Wang; Shan Gao
Source:
Journal of biosafety and biosecurity 2022 v.4 no.1 pp. 75-83
ISSN:
2588-9338
Subject:
ambient temperature; biosafety; biosecurity; bioterrorism; health services; pain; vaccination; vaccines
Abstract:
... Countries must have strong early warning, detection, and response capabilities in the face of the risks and challenges posed by major infectious diseases and bioterrorism threats. Vaccination is one of the most effective means for countries to maintain biosecurity and respond to bioterrorism attacks. Microneedles are emerging as a potential vaccine delivery method with minimal pain, no bleeding, a ...
DOI:
10.1016/j.jobb.2022.04.001

74. Application of pseudovirus system in the development of vaccine, antiviral-drugs, and neutralizing antibodies

Author:
Qi Xiang; Linhao Li; Jie Wu; Miao Tian; Yang Fu
Source:
Microbiological research 2022 v.258 pp. 126993
ISSN:
0944-5013
Subject:
Severe acute respiratory syndrome coronavirus 2; blood serum; genes; pathogenicity; research; vaccination; vaccine development
Abstract:
... Pseudoviruses are viral particles coated with a heterologous envelope protein, which mediates the entry of pseudoviruses as efficiently as that of the live viruses possessing high pathogenicity and infectivity. Due to the deletion of the envelope protein gene and the absence of pathogenic genes, pseudoviruses have no autonomous replication ability and can infect host cells for only a single cycle. ...
DOI:
10.1016/j.micres.2022.126993

75. Are immigrants living in France more reluctant to receive vaccines than native-born French citizens? Findings from the national Health Barometer study

Author:
Sohela Moussaoui; Simon Combes; Gladys Ibanez; Arnaud Gautier; Bridget Relyea; Nicolas Vignier
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
mobile telephones; provenance; regression analysis; risk; vaccination; vaccines; France; Northern Africa; Sub-Saharan Africa
Abstract:
... France is one of the world's most vaccine hesitant countries and vaccine hesitancy (VH) is considered one of the world's leading threats to global health. However, little is known about VH in immigrant populations in France. Using data from the 2016 Health Barometer, we examined VH among newcomers, more established immigrants, and the native-born population in France. Data was collected from Frenc ...
DOI:
10.1016/j.vaccine.2022.05.041

76. Are vaccine shortages a relevant public health issue in Europe? Results from a survey conducted in the framework of the EU Joint Action on Vaccination

Author:
Antonietta Filia; Maria Cristina Rota; Adriano Grossi; Domenico Martinelli; Rosa Prato; Giovanni Rezza
Source:
Vaccine 2022 v.40 no.13 pp. 1987-1995
ISSN:
0264-410X
Subject:
antitoxins; diphtheria; hepatitis A; hepatitis B; public health; stakeholders; supply chain; surveys; vaccination; vaccines; Europe
Abstract:
... National immunisation programmes require an adequate supply of vaccines to function properly but many countries, globally and in Europe, have reported vaccine shortages. A comprehensive view of vaccine shortages and stockouts in the EU/EEA is missing in the published literature. This study was conducted in the framework of the European Joint Action on Vaccination (EU-JAV). Twenty-eight countries, ...
DOI:
10.1016/j.vaccine.2022.02.041

77. Artificial neural network-based estimation of COVID-19 case numbers and effective reproduction rate using wastewater-based epidemiology

Author:
Guangming Jiang; Jiangping Wu; Jennifer Weidhaas; Xuan Li; Yan Chen; Jochen Mueller; Jiaying Li; Manish Kumar; Xu Zhou; Sudipti Arora; Eiji Haramoto; Samendra Sherchan; Gorka Orive; Unax Lertxundi; Ryo Honda; Masaaki Kitajima; Greg Jackson
Source:
Water research 2022 v.218 pp. 118451
ISSN:
0043-1354
Subject:
COVID-19 infection; RNA; Severe acute respiratory syndrome coronavirus 2; cost effectiveness; data collection; monitoring; neural networks; pandemic; reproduction; research; vaccination; virus transmission; wastewater; water; watersheds; weather; Utah; Wisconsin
Abstract:
... As a cost-effective and objective population-wide surveillance tool, wastewater-based epidemiology (WBE) has been widely implemented worldwide to monitor the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA concentration in wastewater. However, viral concentrations or loads in wastewater often correlate poorly with clinical case numbers. To date, there is no reliable method to back ...
DOI:
10.1016/j.watres.2022.118451

78. Assessing an O-antigen deficient, live attenuated Salmonella Gallinarium strain that is DIVA compatible, environmentally safe, and protects chickens against fowl typhoid

Author:
Amal Senevirathne; Chamith Hewawaduge; John Hwa Lee
Source:
Developmental and comparative immunology 2022 v.133 pp. 104433
ISSN:
0145-305X
Subject:
O-antigens; Salmonella; T-lymphocytes; antibodies; blood serum; chickens; cytotoxicity; fowl typhoid; gene deletion; genes; genotype; histopathology; interleukin-12; interleukin-2; interleukin-4; live vaccines; liver; macrophages; spleen; vaccination
Abstract:
... The objective of the present study was to create a highly attenuated, safe Salmonella Gallinarium (SG) vaccine strain for chicken vaccination against fowl typhoid (FT) diseases. The SG vaccine strain (SGVS) consists of three virulence-related gene deletions, namely, lon, cpxR, and rfaL. The parent strain (SGPS) with Δlon ΔcpxR genotype was utilized as the host strain for in-frame rfaL gene deletio ...
DOI:
10.1016/j.dci.2022.104433

79. Assessing machine learning techniques in forecasting lumpy skin disease occurrence based on meteorological and geospatial features

Author:
Ehsanallah Afshari Safavi
Source:
Tropical animal health and production 2022 v.54 no.1 pp. 55
ISSN:
0049-4747
Subject:
Lumpy skin disease virus; algorithms; animal health; arthropods; cattle; disease occurrence; land cover; lumpy skin disease; neural networks; population density; risk; vaccination
Abstract:
... Lumpy skin disease virus (LSDV) causes an infectious disease in cattle. Due to its direct relationship with the survival of arthropod vectors, geospatial and climatic features play a vital role in the epidemiology of the disease. The objective of this study was to assess the ability of some machine learning algorithms to forecast the occurrence of LSDV infection based on meteorological and geologi ...
DOI:
10.1007/s11250-022-03073-2

80. Assessing the economic burden of multi-causal respiratory diseases in broiler farms in Iran

Author:
M. H. Fallah Mehrabadi; A. Ghalyanchilangeroudi; F. Tehrani; S. Amir Hajloo; M. Bashashati; A. R. Bahonar; H. Pourjafar; F. Ansari
Source:
Tropical animal health and production 2022 v.54 no.2 pp. 117
ISSN:
0049-4747
Subject:
Newcastle disease; animal health; chicken meat; disease occurrence; infectious bronchitis; influenza; insurance; society; vaccination; Iran
Abstract:
... The aim of this study was to find the direct economic losses due to the three viral causes of the avian respiratory syndrome, including Newcastle disease (ND), H9N2 influenza, and infectious bronchitis (IB) in stamped-out broiler farms during 2016–2017 across the country. This study was carried out on the information on cross-sectional monitoring in the years 2016–2017. The statistical society of ...
DOI:
10.1007/s11250-022-03110-0

81. Assessing the feasibility of passive surveillance for maternal immunization safety utilizing archival medical records in Kinshasa, Democratic Republic of the Congo

Author:
Adva Gadoth; Dalau Mukadi Nkamba; Patrick J. Arena; Nicole A. Hoff; Camille Dzogang; David Kampilu; Michael Beya; Hui-Lee Wong; Steven A. Anderson; Didine Kaba; Anne W. Rimoin
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
blood flow; fetal death; low birth weight; monitoring; pregnancy; premature birth; safety assessment; small for gestational age; tetanus; vaccination; vaccines; Democratic Republic of the Congo
Abstract:
... Since the establishment of the Global Alignment of Immunization Safety Assessment in pregnancy (GAIA) case definitions in 2015, there has been an urgent need for field validation of pharmacovigilance feasibility in low- and middle-income countries. In this study, we assess the availability and quality of archival medical records at ten randomly selected high-traffic maternity wards in Kinshasa pro ...
DOI:
10.1016/j.vaccine.2022.04.073

82. Assessing the impact of the routine childhood hepatitis B immunization program and the need for hepatitis B vaccine birth dose in Sierra Leone, 2018

Author:
Lucy Breakwell; Dennis Marke; Reinhard Kaiser; Alexandra Tejada-Strop; Matthew D. Pauly; Sonnia Jabbi; Sahr Yambasu; Hyacinte J. Kabore; Brock Stewart; Tom Sesay; Thomas T. Samba; Tonya Hayden; Saleem Kamili; Amara Jambai; Jan Drobeniuc; Tushar Singh; Rania A. Tohme; Annemarie Wasley
Source:
Vaccine 2022 v.40 no.19 pp. 2741-2748
ISSN:
0264-410X
Subject:
DNA; Hepatitis B virus; childhood; hepatitis B; rapid methods; risk; surface antigens; surveys; vaccination; vaccines; vertical disease transmission; Sierra Leone
Abstract:
... Sierra Leone is highly endemic for hepatitis B virus (HBV) infection and thus recommends three doses of hepatitis B vaccine (HepB3) from 6 weeks of age but does not recommend a birth dose (HepB-BD) to prevent mother-to-child transmission (MTCT). We evaluated impact of the existing HepB3 schedule and risk for MTCT of HBV. We conducted a community-based serosurvey among 4–30-month-olds, their mother ...
DOI:
10.1016/j.vaccine.2022.03.049

83. Assessment of Diagnostic Specificity of Anti-SARS-CoV-2 Antibody Tests and Their Application for Monitoring of Seroconversion and Stability of Antiviral Antibody Response in Healthcare Workers in Moscow

Author:
Vera S. Kichatova; Fedor A. Asadi Mobarkhan; Ilya A. Potemkin; Sergey P. Zlobin; Oksana M. Perfilieva; Vladimir T. Valuev-Elliston; Alexander V. Ivanov; Sergey A. Solonin; Mikhail A. Godkov; Maria G. Belikova; Mikhail I. Mikhailov; Karen K. Kyuregyan
Source:
Microorganisms 2022 v.10 no.2 pp. -
ISSN:
2076-2607
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; antibodies; antibody formation; antigens; diagnostic specificity; durability; health care workers; health services; pandemic; risk; seroconversion; seroprevalence; vaccination; vaccines; viruses
Abstract:
... Anti-SARS-CoV-2 antibody testing is an efficient tool to assess the proportion of seropositive population due to infection and/or vaccination. Numerous test systems utilizing various antigen composition(s) are routinely used for detection and quantitation of anti-SARS-CoV-2 antibodies. We determined their diagnostic specificity using archived true-negative samples collected before the onset of the ...
DOI:
10.3390/microorganisms10020429

84. Assessment of a combined treatment with a therapeutic vaccine and benznidazole for the Trypanosoma cruzi chronic infection

Author:
Estefanía Prochetto; Iván Bontempi; Luz Rodeles; Gabriel Cabrera; Miguel Vicco; Paula Cacik; María Florencia Pacini; Mónica Pérez Gianeselli; Ana Rosa Pérez; Iván Marcipar
Source:
Acta tropica 2022 v.229 pp. 106334
ISSN:
0001-706X
Subject:
Chagas disease; Trypanosoma cruzi; adjuvants; benznidazole; drug therapy; electrocardiography; fibrosis; heart; immunogenicity; immunostimulants; mice; myocarditis; parasite load; vaccination; vaccines
Abstract:
... The difficulties encountered in achieving treatments for chronic Chagas disease have promoted the investigation of new therapeutic strategies. In this study, we used two murine models of Trypanosoma cruzi chronic infection to determine the usefulness of applying a therapeutic vaccine alone or followed by benznidazole (Bz) chemotherapy. A vaccine formulation based on an N-terminal fragment of Trans ...
DOI:
10.1016/j.actatropica.2022.106334

85. Assessment of heterologous lumpy skin disease vaccine-induced immunity in pregnant cattle vaccinated at different times of gestation period and their influence on maternally derived antibodies

Author:
Ahmed Gaber; Sherin Rouby; Amera Elsaied; Ahmed El-Sherif
Source:
Veterinary immunology and immunopathology 2022 v.244 pp. 110380
ISSN:
0165-2427
Subject:
cell-mediated immunity; gestation period; humoral immunity; immunopathology; longevity; lumpy skin disease; maternal immunity; parturition; pregnancy; sheep pox; vaccination; vaccines
Abstract:
... The present study aimed to evaluate the cell-mediated and the humoral immune response to Romanian sheep pox vaccine in pregnant cows (n = 12) vaccinated at different times of gestation period and the duration of maternal immunity in calves born to these cows. Evaluation of cellular immunity revealed an increase in lymphocytic proliferation that peaked at 10th day post vaccination (dpv) then gradua ...
DOI:
10.1016/j.vetimm.2021.110380

86. Assessment of maternal immunity against Salmonella enterica serovar Heidelberg in progeny of broiler breeders vaccinated with different formulations of bacterins

Author:
Mailson da Silva Teixeira; Dayse Helena Lages; Victória Veiga Alves; Nelson Rodrigo da Silva Martins; Oliveiro Caetano de Freitas Neto
Source:
Avian pathology 2022 v.51 no.2 pp. 197-205
ISSN:
1465-3338
Subject:
Salmonella Heidelberg; broiler breeders; cecum; excretion; flocks; gastrointestinal diseases; liver; maternal immunity; progeny; spleen; vaccination; vaccines
Abstract:
... Salmonella Heidelberg (SH) has been reported in broiler flocks of many countries. The ability of some SH strains of poultry origin to cause foodborne infections in humans is a concern. Usually, infection of broiler flocks by SH occurs in the first days of life. Therefore, control measures should start early post-hatch. One of the strategies is to generate high titres of anti-Salmonella IgY in bree ...
DOI:
10.1080/03079457.2022.2039592

87. Assessment of the Vaccination Program against Cystic Echinococcosis in Sheep in the Pehuenche Community of Central Chile

Author:
Paula Gädicke; David Heath; Angela Medina-Brunet; María Carolina Siva-de la Fuente; Hellen Espinoza-Rojas; Carmen Villaguala-Pacheco; Makarena Rubilar; Carolina Cerda; Manuel Quezada; Daniela Rojas; AnaLía Henríquez; Marco Loyola; Carlos Landaeta-Aqueveque
Source:
Animals 2022 v.12 no.6 pp. -
ISSN:
2076-2615
Subject:
deworming; dogs; echinococcosis; endemic diseases; protoscoleces; sheep; vaccination; vaccines; zoonoses; Chile
Abstract:
... Echinococcosis is a neglected zoonosis that uses dogs and sheep as its main hosts in Chile. The Eg95 vaccine against sheep infection has been included in some control programs. Here, we assess the efficacy of the vaccination program in the hyperendemic Alto Biobío commune after 3 years of execution. Fisher’s test and generalized linear models were used in the assessment. The program tried to offer ...
DOI:
10.3390/ani12060679

88. Association of household cooking location behaviour with acute respiratory infections among children aged under five years; a cross sectional analysis of 30 Sub-Saharan African Demographic and Health Surveys

Author:
Katherine E. Woolley; G. Neil Thomas; Bruce Kirenga; Gabriel Okello; Telesphore Kabera; Xiang-Qian Lao; Francis D. Pope; Sheila M. Greenfield; Malcolm J. Price; Suzanne E. Bartington; on behalf of Global - CLEAR
Source:
Atmospheric environment 2022 v.276 pp. 119055
ISSN:
1352-2310
Subject:
air pollution; biofuels; biomass; charcoal; children; coal; cough; cross-sectional studies; dyspnea; environment; fever; health surveys; mortality; regression analysis; vaccination; wet season; Sub-Saharan Africa
Abstract:
... Cooking location among households using solid biomass cooking fuels may have implications for exposure to harmful levels of Household Air Pollution (HAP). However, little is known about the predictors of cooking location and their association with Acute Respiratory Infections (ARI); a leading cause of mortality in children aged under five years worldwide, which has child nutritional status, vaccin ...
DOI:
10.1016/j.atmosenv.2022.119055

89. At the heart of a dog's veterinary experience: Heart rate responses in dogs vary across a standard physical examination

Author:
Petra T. Edwards; Bradley P. Smith; Michelle L. McArthur; Susan J. Hazel
Source:
Journal of veterinary behavior 2022 v.51 pp. 23-34
ISSN:
1558-7878
Subject:
clinical examination; dogs; fearfulness; females; heart; heart rate; legs; males; risk; tail; vaccination
Abstract:
... Regular veterinary care is integral to companion dog health and welfare, but fearful patients can inhibit provision of care and pose a risk of injury to veterinary staff. This study aimed to identify the physiological and behavioral responses of a sample of 30 dogs of various age and breed, to a standardized physical examination in a simulated veterinary setting. Fear was measured using heart rate ...
DOI:
10.1016/j.jveb.2022.03.003

90. Attacking the Intruder at the Gate: Prospects of Mucosal Anti SARS-CoV-2 Vaccines

Author:
Kacper Karczmarzyk; Małgorzata Kęsik-Brodacka
Source:
Pathogens 2022 v.11 no.2 pp. -
ISSN:
2076-0817
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; herd immunity; humans; pandemic; respiratory system; vaccination; vaccines; viruses
Abstract:
... The sudden outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic in December 2019 caused crises and health emergencies worldwide. The rapid spread of the virus created an urgent need for the development of an effective vaccine and mass immunization to achieve herd immunity. Efforts of scientific teams at universities and pharmaceutical companies around the world all ...
DOI:
10.3390/pathogens11020117

91. Attitude toward a mandatory COVID-19 vaccination policy and its determinants: Evidence from serial cross-sectional surveys conducted throughout the pandemic in Germany

Author:
Philipp Sprengholz; Lars Korn; Sarah Eitze; Lisa Felgendreff; Regina Siegers; Laura Goldhahn; Freia De Bock; Lena Huebl; Robert Böhm; Cornelia Betsch
Source:
Vaccine 2022 pp. -
ISSN:
0264-410X
Subject:
COVID-19 infection; ethics; issues and policy; pandemic; vaccination; vaccines; Germany
Abstract:
... Mandating vaccination against COVID-19 is often discussed as a means to counter low vaccine uptake. Beyond the potential legal, ethical, and psychological concerns, a successful implementation also needs to consider citizens’ support for such a policy. Public attitudes toward vaccination mandates and their determinants might differ over time and, hence, should be monitored. Between April 2020 and ...
DOI:
10.1016/j.vaccine.2022.01.065

92. Attitudes of junior healthcare professionals towards mandatory vaccination

Author:
Ioanna Kakatsaki; Eleni Vergadi; Emmanouil Paraskakis; Emmanouil Galanakis
Source:
Vaccine 2022 v.40 no.15 pp. 2247-2250
ISSN:
0264-410X
Subject:
compliance; cross-sectional studies; employment; fearfulness; health services; questionnaires; social benefit; surveys; vaccination; vaccines
Abstract:
... Vaccination of healthcare professionals (HCPs) is a key measure to prevent infections in healthcare facilities, but uptake rates often remain low. Mandatory vaccination policies have been occasionally implemented to increase compliance among HCPs, but this remains an issue of controversy. The purpose of this survey was to assess the attitudes and beliefs of trainee HCPs towards mandatory occupatio ...
DOI:
10.1016/j.vaccine.2022.03.010

93. Attitudes towards vaccination and knowledge about antibiotics: Analysis of Wellcome Monitor survey data

Author:
Alistair Anderson
Source:
Vaccine 2022 v.40 no.22 pp. 3038-3045
ISSN:
0264-410X
Subject:
adverse effects; antibiotic resistance; antibiotics; public health; qualitative analysis; regression analysis; risk; surveys; vaccination; vaccines
Abstract:
... Vaccine hesitancy and antimicrobial resistance are biomedically connected public health challenges, but to date minimal research has examined social connections between the UK public’s attitudes towards vaccination and attitudes towards antibiotic use. Understanding the extent to which these issues are attitudinally parallel would be valuable for implementing and evaluating public health intervent ...
DOI:
10.1016/j.vaccine.2022.04.024

94. Avian Influenza a H9N2 Viruses in Morocco, 2018–2019

Author:
Fatima-Zohra Sikht; Mariette Ducatez; Charifa Drissi Touzani; Adam Rubrum; Richard Webby; Mohammed El Houadfi; Nour-Said Tligui; Christelle Camus; Siham Fellahi
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Influenza A virus; amino acids; avian influenza; phylogeny; vaccination; virulence; viruses; Morocco
Abstract:
... Low pathogenic H9N2 avian influenza (LPAI H9N2) is considered one of the most important diseases found in poultry (broiler, laying hens, breeding chickens, and turkeys). This infection causes considerable economic losses. The objective of this work was to monitor and assess the presence of avian influenza virus (AIV) H9N2 in eight different regions of Morocco using real-time RT-PCR, and to assess ...
DOI:
10.3390/v14030529

95. Avian metapneumovirus subtype B vaccination in commercial broiler chicks: heterologous protection and selected host transcription responses to subtype A or B challenge

Author:
Christopher Ball; Basim Manswr; Andreas Herrmann; Stephane Lemiere; Kannan Ganapathy
Source:
Avian pathology 2022 v.51 no.2 pp. 181-196
ISSN:
1465-3338
Subject:
Avian metapneumovirus; antibodies; cell-mediated immunity; egg production; gene expression; genes; immune response; interleukin-18; interleukin-6; lungs; respiratory tract diseases; transcription (genetics); vaccination; virulence
Abstract:
... Avian metapneumovirus (aMPV) causes respiratory disease and drops in egg production in chickens, and is routinely controlled by vaccination. However, the host’s immune response to virulent challenge in vaccinated or unvaccinated broiler chickens is poorly characterized. We show that subtype B vaccination offers heterologous (subtype A challenge) and homologous (subtype B challenge) protection. Sub ...
DOI:
10.1080/03079457.2022.2036697

96. BCG vaccination and the risk of COVID 19: A possible correlation

Author:
Sara M. Ahmed; Mohamed A. Nasr; Shimaa E. Elshenawy; Alaa E. Hussein; Ahmed H. El-Betar; Rania Hassan Mohamed; Nagwa El-Badri
Source:
Virology 2022 v.565 pp. 73-81
ISSN:
0042-6822
Subject:
BCG vaccine; COVID-19 infection; Mycobacterium bovis BCG; RNA; Severe acute respiratory syndrome coronavirus 2; data collection; gene expression regulation; humans; immune response; monocytes; mortality; risk; tuberculosis; vaccination; virology
Abstract:
... Bacillus Calmette–Guérin (BCG) vaccine is currently used to prevent tuberculosis infection. The vaccine was found to enhance resistance to certain types of infection including positive sense RNA viruses. The current COVID-19 pandemic is caused by positive sense RNA, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A higher mortality rate of COVID-19 patients was reported in countries ...
DOI:
10.1016/j.virol.2021.10.003

97. Background incidence rates of adverse events of special interest related to COVID-19 vaccines in Ontario, Canada, 2015 to 2020, to inform COVID-19 vaccine safety surveillance

Author:
Sharifa Nasreen; Andrew Calzavara; Sarah A. Buchan; Nisha Thampi; Caitlin Johnson; Sarah E. Wilson; Jeffrey C. Kwong; on behalf of the Canadian Immunization Research Network (CIRN) Provincial Collaborative Network (PCN) Ontario investigators
Source:
Vaccine 2022 v.40 no.24 pp. 3305-3312
ISSN:
0264-410X
Subject:
COVID-19 infection; anaphylaxis; childhood; encephalitis; females; monitoring; myocardial infarction; myocarditis; observational studies; pericarditis; thrombocytopenia; vaccination; vaccines; Ontario
Abstract:
... Background incidence rates are critical in pharmacovigilance to facilitate identification of vaccine safety signals. We estimated background incidence rates of 11 adverse events of special interest related to COVID-19 vaccines in Ontario, Canada. We conducted a population-based retrospective observational study using linked health administrative databases for hospitalizations and emergency departm ...
DOI:
10.1016/j.vaccine.2022.04.065

98. Baculovirus-derived influenza virus-like particle confers complete protection against lethal H7N9 avian influenza virus challenge in chickens and mice

Author:
Jiao Hu; Qi Zhang; Peipei Peng; Rumeng Li; Jun Li; Xiaoquan Wang; Min Gu; Zenglei Hu; Shunlin Hu; Xiaowen Liu; Mei Mei; Xinan Jiao; Daxin Peng; Xiufan Liu
Source:
Veterinary microbiology 2022 v.264 pp. 109306
ISSN:
0378-1135
Subject:
Baculoviridae; Influenza A virus; T-lymphocytes; antibodies; avian influenza; chemokine CCL5; chickens; cross reaction; genes; insects; interleukin-2; interleukin-4; interleukin-6; lungs; mice; mixed infection; pandemic; vaccination; virus-like particle vaccines; viruses
Abstract:
... Currently, highly pathogenic avian influenza (HPAI) H7N9 viruses still pose a potential pandemic threat. Influenza virus-like particle (VLP) is one of the most promising vaccine strategies to complement traditional egg-dependent vaccines. Here, we generated a H7N9 VLP vaccine candidate by baculovirus expression system and evaluated its efficacy in chickens and mice. The H7N9 VLP was produced throu ...
DOI:
10.1016/j.vetmic.2021.109306

99. Bayesian Inference of State-Level COVID-19 Basic Reproduction Numbers across the United States

Author:
Abhishek Mallela; Jacob Neumann; Ely F. Miller; Ye Chen; Richard G. Posner; Yen Ting Lin; William S. Hlavacek
Source:
Viruses 2022 v.14 no.1 pp. -
ISSN:
1999-4915
Subject:
Bayesian theory; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; basic reproduction number; herd immunity; models; reproduction; seroprevalence; surveys; vaccination; New Jersey; Wyoming
Abstract:
... Although many persons in the United States have acquired immunity to COVID-19, either through vaccination or infection with SARS-CoV-2, COVID-19 will pose an ongoing threat to non-immune persons so long as disease transmission continues. We can estimate when sustained disease transmission will end in a population by calculating the population-specific basic reproduction number ℛ0, the expected num ...
DOI:
10.3390/v14010157

100. Behavioral predictors of household food-safety practices during the COVID-19 pandemic: Extending the theory of planned behavior

Author:
Raísa Moreira Dardaque Mucinhato; Diogo Thimoteo da Cunha; Simone Crispim Fernandes Barros; Laís Mariano Zanin; Lígia Isoni Auad; Grazielle Castagna Cezimbra Weis; Ana Lúcia de Freitas Saccol; Elke Stedefeldt
Source:
Food control 2022 v.134 pp. 108719
ISSN:
0956-7135
Subject:
COVID-19 infection; consumer behavior; equations; food handling; food safety; public health; questionnaires; risk perception; vaccination; Brazil
Abstract:
... The epidemiological scenario of COVID-19, social distancing, and business restrictions has increased food preparation and consumption at home. Food mishandling at home can significantly raise the risk of foodborne diseases. This study investigates food-mishandling behavior predictors by applying the extended theory of planned behavior (TPB), with the addition of knowledge and risk perception, to h ...
DOI:
10.1016/j.foodcont.2021.108719