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61. Curcumin-nicotinamide cocrystallization with supercritical solvent (CSS): Synthesis, characterization and in vivo antinociceptive and anti-inflammatory activities

Author:
Ribas, Marcela M.; Aguiar, Gean Pablo S.; Muller, Liz G.; Siebel, Anna M.; Lanza, Marcelo; Oliveira, J. Vladimir
Source:
Industrial crops and products 2019 v.139 pp. 111537
ISSN:
0926-6690
Subject:
bioavailability,   etc   ; active pharmaceutical ingredients; anti-inflammatory activity; antimalarials; antioxidant activity; curcumin; pharmaceutical industry; polyphenols; solubility; solvents;     Show all 10 Subjects
Abstract:
... Curcumin is a bioactive polyphenol, which presents several medicinal benefits such as antinociceptive, anti-inflammatory, anti-carcinogenic, antimalarial, and antioxidant activity. Despite the benefits, the main barrier in curcumin use by pharmaceutical industry is its low solubility in water medium and hence low bioavailability. The cocrystallization process is characterized by the incidence of m ...
DOI:
10.1016/j.indcrop.2019.111537

62. Gastric/lung bioaccessibility and identification of arsenic-bearing phases and sources of fine surface dust in a gold mining district

Author:
Morais, Marcos A.; Gasparon, Massimo; Delbem, Itamar D.; Caldeira, Claudia L.; Freitas, Erico T.F.; Ng, Jack C.; Ciminelli, Virginia S.T.
Source:
The Science of the total environment 2019 v.689 pp. 1244-1254
ISSN:
0048-9697
Subject:
bioavailability,   etc   ; arsenic; automation; body weight; breathing; dust; gastrointestinal system; goethite; gold; hematite; image analysis; ingestion; iron; lungs; mining; nanomaterials; particle size; risk; soil sampling; solubility; transmission electron microscopy;     Show all 21 Subjects
Abstract:
... Bioaccessibility (BAC) of fine surface dust (FSD, particle size ≤10 μm) and surface dust samples (particle size ≤250 μm) collected from a gold mining district was used as a tool to determine the portion of arsenic that would be available via simulated lung and gastrointestinal (G.I) fluids. BAC was considered low for both tests (lung 2.7 ± 1%, n = 5 and G.I 3.4 ± 2%, n = 14 for residential surface ...
DOI:
10.1016/j.scitotenv.2019.06.394

63. Integrative response of arsenic uptake, speciation and detoxification by Salix atrocinerea

Author:
Navazas, Alejandro; Hendrix, Sophie; Cuypers, Ann; González, Aida
Source:
The Science of the total environment 2019 v.689 pp. 422-433
ISSN:
0048-9697
Subject:
bioavailability,   etc   ; Salix atrocinerea; arsenic; biometry; brownfields; chronic exposure; gene expression; genes; hydroponics; leaves; messenger RNA; metabolism; phytoremediation; polluted soils; roots; thiols; tissues; toxicity; transcriptomics;     Show all 19 Subjects
Abstract:
... Despite arsenic (As) being very toxic with deleterious effects on metabolism, it can be tolerated and accumulated by some plants. General genetic mechanisms responsible for As tolerance in plants, including Salix species, have been described in transcriptomic analysis, but further experimental verification of the significance of particular transcripts is needed. In this study, a Salix atrocinerea ...
DOI:
10.1016/j.scitotenv.2019.06.279

64. Micronization of thymol by RESS and its larvicidal activity against Aedes aegypti (Diptera, Culicidae)

Author:
Martello, Rafael Henrique; Gallon, Carine; Alijar Souza, Maryelen; Fossá Calisto, Jean Felipe; Aguiar, Gean Pablo S.; Albeny-Simões, Daniel; Vladimir Oliveira, J.; Dal Magro, Jacir
Source:
Industrial crops and products 2019 v.139 pp. 111495
ISSN:
0926-6690
Subject:
bioavailability,   etc   ; Aedes aegypti; GRAS substances; antioxidant activity; drugs; insecticides; instars; larvae; larvicides; mortality; parasites; particle size; pharmaceutical industry; secondary metabolites; thyme; thyme oil; thymol; vector control; water solubility;     Show all 19 Subjects
Abstract:
... Micronization techniques by supercritical fluid has been drawing attention from chemical and pharmaceutical industries due to its potential and innovation. Thymol is a phenolic compound with high antimicrobial and efficient antioxidant activities, due to its non-toxic and antimutagenic features is classified as Generally Recognized as Safe by the Food & Drug Administration. However, the highly vol ...
DOI:
10.1016/j.indcrop.2019.111495

65. Nickel and iron partitioning between clay minerals, Fe-oxides and Fe-sulfides in lagoon sediments from New Caledonia

Author:
Merrot, Pauline; Juillot, Farid; Noël, Vincent; Lefebvre, Pierre; Brest, Jessica; Menguy, Nicolas; Guigner, Jean-Michel; Blondeau, Marine; Viollier, Eric; Fernandez, Jean-Michel; Moreton, Benjamin; Bargar, John R.; Morin, Guillaume
Source:
The Science of the total environment 2019 v.689 pp. 1212-1227
ISSN:
0048-9697
Subject:
bioavailability,   etc   ; X-ray absorption spectroscopy; biogeochemical cycles; carbonates; clay; coastal ecosystems; coral reefs; diagenesis; estuaries; iron; iron oxides; iron oxyhydroxides; laterites; nickel; organic carbon; pyrite; sediments; silicates; smectite; sulfates; sulfur; tropics; weathering; New Caledonia;     Show all 24 Subjects
Abstract:
... In the tropics, continental weathering and erosion are major sources of trace metals towards estuaries and lagoons, where early diagenesis of sediments may influence their mobility and bioavailability. Determining trace metals speciation in tropical sedimentary settings is thus needed to assess their long-term fate and potential threat to fragile coastal ecosystems. In this study, we determined Fe ...
DOI:
10.1016/j.scitotenv.2019.06.274

66. Structure, bioactivity and applications of natural hyperbranched polysaccharides

Author:
Chen, Lei; Ge, Meng-Die; Zhu, Yu-Jie; Song, Yu; Cheung, Peter C.K.; Zhang, Bo-Bo; Liu, Li-Ming
Source:
Carbohydrate polymers 2019 v.223 pp. 115076
ISSN:
0144-8617
Subject:
bioavailability,   etc   ; animals; bioactive properties; biocompatibility; biodegradability; biopolymers; fungi; medicine; moieties; nanomaterials; polysaccharides;     Show all 11 Subjects
Abstract:
... In recent years, hyperbranched polymers, especially the natural hyperbranched polysaccharides (HBPSs), are receiving much attention due to their diverse biological activities and applications. With high degree of branching (DB), HBPSs mainly exist in the form of either a comb-brush shape, dendrimer-like particulate, or globular particle. HBPSs also possess some unique properties, such as high dens ...
DOI:
10.1016/j.carbpol.2019.115076

67. Sustained release of ketorolac tromethamine from poloxamer 407/cellulose nanofibrils graft nanocollagen based ophthalmic formulations

Author:
Orasugh, Jonathan Tersur; Dutta, Soumyadip; Das, Diphankar; Pal, Chandrika; Zaman, Aisha; Das, Sreyasi; Dutta, Koushik; Banerjee, Rajdeb; Ghosh, Swapan Kumar; Chattopadhyay, Dipankar
Source:
International journal of biological macromolecules 2019 v.140 pp. 441-453
ISSN:
0141-8130
Subject:
bioavailability,   etc   ; cellulose; cellulose nanofibers; collagen; drug delivery systems; drugs; gel strength; gelation; gels; nanocomposites;     Show all 10 Subjects
Abstract:
... There has been extensive utilization of poloxamer 407 (PM) for the delivery of various ophthalmic drugs aimed at efficient ophthalmic drug delivery approach for longer precorneal residence time along with acceptable bioavailability of drugs. We have studied the effect of nanocellulose grafted collagen (CGC) on the performance of in situ gels based on PM for the controlled in vitro release of Ketor ...
DOI:
10.1016/j.ijbiomac.2019.08.143

68. Aging-independent and size-dependent genotoxic response induced by titanium dioxide nanoparticles in mammalian cells

Author:
Wang, Juan; Wang, Jingjing; Liu, Yun; Nie, Yaguang; Si, Bo; Wang, Tong; Waqas, Ahmed; Zhao, Guoping; Wang, Meimei; Xu, An
Source:
Journal of environmental sciences (China) 2019 v.85 pp. 94-106
ISSN:
1001-0742
Subject:
bioavailability,   etc   ; adverse effects; cytotoxicity; genotoxicity; hydrodynamics; mammals; mitochondria; mitochondrial DNA; monitoring; mutagens; nanoparticles; titanium dioxide;     Show all 12 Subjects
Abstract:
... Titanium dioxide nanoparticles (TiO2 NPs) are subjected to various transformation processes (chemical, physical and biological processes) in the environment, potentially affecting their bioavailability and toxic properties. However, the size variation of TiO2 NPs during aging process and subsequent effects in mammalian cells are largely unknown. The aim of this study was to illustrate the adverse ...
DOI:
10.1016/j.jes.2019.04.024

69. A tiered analytical approach for target, non-target and suspect screening analysis of polar transformation products of polycyclic aromatic compounds

Author:
Schemeth, Dieter; Nielsen, Nikoline J.; Andersson, Jan T.; Christensen, Jan H.
Source:
Chemosphere 2019 v.235 pp. 175-184
ISSN:
0045-6535
Subject:
bioavailability,   etc   ; anion exchange; aromatic compounds; basins; carboxylation; databases; dicarboxylic acids; environmental factors; fatty acids; gas chromatography-mass spectrometry; hydroxylation; liquid chromatography; photooxidation; polycyclic compounds; runoff; screening; solid phase extraction; toxicity; weathering; Arctic region;     Show all 20 Subjects
Abstract:
... Polycyclic aromatic compounds (PACs) possess toxicity towards humans, and their presence in the environment is unwanted. Polar transformation products (TPs) are more mobile, and can be considered emerging contaminants, as they represent a more bioavailable carrier of the same toxic properties. Acidic TPs has been proposed as an important class of polar TPs. This study presents a tiered analytical ...
DOI:
10.1016/j.chemosphere.2019.06.149

70. Cadmium phytoavailability evaluation in rice-soil system using a field capacity-derived soil solution extraction: An entire growth period study in subtropical China

Author:
Chen, Qi; Peng, Pei-Qin; Long, Jian; Li, Xin-Yang; Ding, Xianqing; Hou, Hong-Bo; Liao, Bo-Han
Source:
Soil & tillage research 2019 v.194 pp. 104315
ISSN:
0167-1987
Subject:
bioavailability,   etc   ; Oryza sativa; brown rice; cadmium; heading; hulls; hydrochloric acid; leaching; leaves; paddy soils; prediction; rice soils; roots; soil solution; tillering; tissues; toxicity; China;     Show all 18 Subjects
Abstract:
... While the evaluation of cadmium (Cd) phytoavailability in rice (Oryza sativa L.)–soil systems has attracted considerable attention in recent years, the results vary based on the evaluation method used. The objective of this work was to use field capacity-derived soil solution extraction (SSE) to evaluate the Cd phytoavailability in two typical paddy soils (purple paddy soil and red paddy soil) dur ...
DOI:
10.1016/j.still.2019.104315

71. Characterizing vertical migration of 137Cs in organic layer and mineral soil in Japanese forests: Four-year observation and model analysis

Author:
Muto, Kotomi; Atarashi-Andoh, Mariko; Matsunaga, Takeshi; Koarashi, Jun
Source:
Journal of environmental radioactivity 2019 v.208-209 pp. 106040
ISSN:
0265-931X
Subject:
bioavailability,   etc   ; accidents; cesium radioisotopes; diffusivity; equations; forest ecosystems; forest soils; forests; inventories; migratory behavior; mineral soils; models; nuclear power; power plants; prediction; radioactivity; risk; soil profiles; Japan; Ukraine;     Show all 20 Subjects
Abstract:
... Because of the Fukushima Dai-ichi Nuclear Power Plant accident, forest ecosystems in wide areas were contaminated with 137Cs. It is important to characterize the behavior of 137Cs after its deposition onto forest surface environments for evaluating and preventing long-term radiation risks. In the present study, 137Cs vertical distributions in the soil profile were observed repeatedly at five fores ...
DOI:
10.1016/j.jenvrad.2019.106040

72. Construction and multifunctionalization of chitosan-based three-phase nano-delivery system

Author:
Sun, Xinyu; Jia, Pei; Zhe, Taotao; Bu, Tong; Liu, Yingnan; Wang, Qinzhi; Wang, Li
Source:
Food hydrocolloids 2019 v.96 pp. 402-411
ISSN:
0268-005X
Subject:
bioavailability,   etc   ; antibacterial properties; antioxidants; chitosan; crosslinking; food composition; food industry; functional foods; hydrocolloids; lysozyme; nanoparticles; pharmaceutical industry; ultrasonics;     Show all 13 Subjects
Abstract:
... Functional food components have attracted extensive attention for their nutritional and physiological properties. However, the instability and low bioavailability seriously limited their applications in the food and pharmaceutical industries. Herein, we successfully constructed a multifunctional three-phase nano-delivery system of polysaccharide-polyphenol-protein, namely chitosan-tannin-lysozyme ...
DOI:
10.1016/j.foodhyd.2019.05.040

73. Effect of adding alpha-tocopherol on the oxidation advance during in vitro gastrointestinal digestion of sunflower and flaxseed oils

Author:
Nieva-Echevarría, Bárbara; Goicoechea, Encarnación; Guillén, María D.
Source:
Food research international 2019 v.125 pp. 108558
ISSN:
0963-9969
Subject:
bioavailability,   etc   ; Helianthus annuus; aldehydes; alpha-tocopherol; dose response; gas chromatography-mass spectrometry; gastrointestinal system; in vitro digestion; in vitro studies; in vivo studies; linseed oil; lipid peroxidation; lipids; lipolysis; models; nuclear magnetic resonance spectroscopy; oxidation; solid phase microextraction;     Show all 18 Subjects
Abstract:
... Few in vitro studies have tackled the effect of alpha-tocopherol on lipid oxidation during digestion, and discrepant results have been reported. As a result, the aim of this study was to elucidate whether the addition of alpha-tocopherol enhances or slows down the advance of oxidation that occurs during in vitro gastrointestinal digestion of polyunsaturated lipids. For this purpose, commercial sun ...
DOI:
10.1016/j.foodres.2019.108558

74. Encapsulation of quercetin-loaded β-lactoglobulin for drug delivery using modified anti-solvent method

Author:
Chavoshpour-Natanzi, Zahra; Sahihi, Mehdi
Source:
Food hydrocolloids 2019 v.96 pp. 493-502
ISSN:
0268-005X
Subject:
bioavailability,   etc   ; acetone; acidity; atomic force microscopy; beta-lactoglobulin; biocompatibility; crosslinking; drug carriers; encapsulation; evaporation; gastric juice; glutaraldehyde; hydrocolloids; hydrophobicity; in vitro digestion; ionic strength; kinetics; nanoparticles; pH; particle size; pepsin; quercetin; scanning electron microscopy; toxicity; trypsin; water solubility;     Show all 26 Subjects
Abstract:
... Many scientists use proteins as attractive bio-availability enhancers for natural compounds and pharmaceuticals which have poor water solubility, due to their natural abundance, amphiphilic nature, and desirable biocompatibility. Here, we investigate the preparation, characterization, and application of β-Lactoglobulin (BLG) based nanoparticles for encapsulation of quercetin, systematically. We us ...
DOI:
10.1016/j.foodhyd.2019.05.051

75. Evaluation of mercury availability to pea parts (Pisum sativum L.) in urban soils: Comparison between diffusive gradients in thin films technique and plant model

Author:
Pelcová, Pavlína; Zouharová, Iveta; Ridošková, Andrea; Smolíková, Vendula
Source:
Chemosphere 2019 v.234 pp. 373-378
ISSN:
0045-6535
Subject:
bioavailability,   etc   ; Pisum sativum; acid deposition; leaves; mercury; models; peas; polluted soils; soil sampling; soil solution; urban soils;     Show all 11 Subjects
Abstract:
... The diffusive gradients in thin films technique (DGT) was used for the determination of bioavailable mercury in urban soils, and results were compared to the mercury accumulation by Pisum sativum L. (pea) parts (leaf, root, stem, blossom, legume, and green seed). The total mercury concentration in soil samples was ranged between 0.084 and 0.326 mg kg−1. The soil solutions contained 0.15%–0.20% of ...
DOI:
10.1016/j.chemosphere.2019.06.076

76. Evaluation of the sedative effects and pharmacokinetics of detomidine gel administered intravaginally to horses

Author:
Seddighi, Reza; Knych, Heather K.; Cox, Sherry K.; Sun, Xiaocun; Moorhead, Kaitlin A.; Doherty, Thomas J.
Source:
Veterinary anaesthesia and analgesia 2019 v.46 no.6 pp. 772-779
ISSN:
1467-2987
Subject:
bioavailability,   etc   ; adults; ataxia (disorder); blood sampling; detomidine; gels; heart rate; intravenous injection; liquid chromatography; mares; metabolites; pharmacokinetics; sedation; tandem mass spectrometry;     Show all 14 Subjects
Abstract:
... To determine the sedative effects and pharmacokinetic profile of detomidine when administered intravaginally as a gel formulation to horses.Randomized, crossover, masked experimental design.A group of six healthy adult mares (494 ± 56 kg).Mares were studied on two occasions and were administered either detomidine hydrochloride (10 μg kg–1) intravenously (treatment IV) or detomidine gel (40 μg kg–1 ...
DOI:
10.1016/j.vaa.2019.06.002

77. Expression and characterization of human lactoferrin with tandem zinc finger protein in Chlamydomonas reinhardtii

Author:
Pang, Xiaonan; Tong, Yuxi; Li, Fang; Wei, Xuan; Chen, Xiwen; Liu, Jia; Chen, Defu
Source:
Algal research 2019 v.43 pp. 101635
ISSN:
2211-9264
Subject:
bioavailability,   etc   ; 2,2-diphenyl-1-picrylhydrazyl; Chlamydomonas reinhardtii; Escherichia coli; Klebsiella variicola; absorption; antibacterial properties; antioxidant activity; clones; genes; glycoproteins; hydroxyl radicals; intestinal mucosa; lactoferrin; small intestine; temperature; zinc finger motif;     Show all 17 Subjects
Abstract:
... Lactoferrin (LF) is a naturally occurring iron-binding glycoprotein with a number of biological functions. However, its bioavailability remains a major limitation for clinical applications. In this study, we explored the expression of functional human lactoferrin (hLF) containing tandem zinc finger protein (ZFP) repeats in Chlamydomonas reinhardtii. Codon-optimized ZFPn-hLF fusion genes, where n d ...
DOI:
10.1016/j.algal.2019.101635

78. Fabrication of N-acetyl-l-cysteine and l-cysteine functionalized chitosan-casein nanohydrogels for entrapment of hydrophilic and hydrophobic bioactive compounds

Author:
Du, Zhiyang; Liu, Jingbo; Zhai, Jinxing; Huang, Haitao; Wei, Shibiao; Zhang, Ting; Ding, Long; Liu, Boqun
Source:
Food hydrocolloids 2019 v.96 pp. 377-384
ISSN:
0268-005X
Subject:
bioavailability,   etc   ; Fourier transform infrared spectroscopy; acetylcysteine; ambient temperature; bioactive compounds; casein; chemical interactions; chitosan; curcumin; cysteine; drugs; egg albumen; electrostatic interactions; encapsulation; hydrocolloids; hydrophilicity; hydrophobicity; intestines; light scattering; pH; particle size; peptides; sodium hydroxide; storage quality;     Show all 24 Subjects
Abstract:
... In this work, we present self-assembly nanohydrogels (NGs) systems for controlled and sustained release of hydrophilic as well as hydrophobic bioactive compounds. Specifically, N-acetyl-l-cysteine (NAC) and l-cysteine (CYS) functionalized chitosan (CS) and NaOH modified casein (CA) were synthesized by layer-by-layer electrostatic interaction to enhance the bioavailability of egg white derived pept ...
DOI:
10.1016/j.foodhyd.2019.05.039

79. Heteroprotein complex formation of ovotransferrin and lysozyme: Fabrication of food-grade particles to stabilize Pickering emulsions

Author:
Wei, Zihao; Cheng, Yujia; Huang, Qingrong
Source:
Food hydrocolloids 2019 v.96 pp. 190-200
ISSN:
0268-005X
Subject:
bioavailability,   etc   ; ambient temperature; curcumin; dietary supplements; electrostatic interactions; emulsions; encapsulation; hydrocolloids; lipolysis; lysozyme; oils; pH; particle size; screening; sodium chloride; stabilizers; storage temperature; turbidity; viscosity; wettability; zeta potential;     Show all 21 Subjects
Abstract:
... The present work aimed to fabricate food-grade Pickering emulsions stabilized by heteroprotein complexes formed by ovotransferrin (OVT) and lysozyme (LYS) as lipid-based nutraceutical delivery vehicles. The heteroprotein complexation, as confirmed by turbidity titrations, was proved to be an effective means to prepare food-grade particles. Multiple parameters such as particle size, zeta potential ...
DOI:
10.1016/j.foodhyd.2019.05.024

80. Interactive effects of microplastics and glyphosate on the dynamics of soil dissolved organic matter in a Chinese loess soil

Author:
Liu, Hongfei; Yang, Xiaomei; Liang, Chutao; Li, Yuanze; Qiao, Leilei; Ai, Zemin; Xue, Sha; Liu, Guobin
Source:
Catena 2019 v.182 pp. 104177
ISSN:
0341-8162
Subject:
bioavailability,   etc   ; agricultural soils; dissolved organic matter; earthworms; enzyme activity; fluorescein diacetate; glyphosate; hydrolases; loess soils; microbial carbon; microplastics; monophenol monooxygenase; nitrogen; organic phosphorus; pesticide residues; plastic film; polypropylenes;     Show all 17 Subjects
Abstract:
... The increased use of plastic films and pesticides on agricultural soil leads to the accumulation of plastic debris and pesticide residues in soil. This accumulation has become a serious environmental issue, as it threatens life of earthworms, inhibits the enzyme activities and microbial diversity, and contributes to the loss of soil microbial carbon and nitrogen. However, little information is ava ...
DOI:
10.1016/j.catena.2019.104177