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1. Comparative transcriptome analyses on terpenoids metabolism in field- and mountain-cultivated ginseng roots

Author:
Fan, Hang,   et al.   ; Li, Ke; Yao, Fan; Sun, Liwei; Liu, Yujun;     Show all 5 Authors
Source:
BMC plant biology 2019 v.19 no.1 pp. 82
ISSN:
1471-2229
Subject:
Panax ginseng; abscisic acid; biosynthesis; carotenoids; chemical constituents of plants; diterpenoids; genes; gibberellins; ginsenosides; monoterpenoids; quinones; roots; steroids; vegetative growth
Abstract:
... BACKGROUND: There exist differences in morphological traits and phytochemical compositions between field- and mountain-cultivated Panax ginseng (FCG and MCG), which might be attributed to variations of terpenoids metabolism adapting to different growth conditions. The present work aims to uncover these variations. RESULTS: Among 26,648 differentially expressed genes, 496 genes distributed in seven ...
DOI:
10.1186/s12870-019-1682-5

2. Amelioration of alcohol-induced liver injury in mice by ginsenosides in ginseng wine

Author:
Fan, Hang,   et al.   ; Li, Ke; Wang, Lin; Zhou, Ran; Sui, Jinling;     Show all 5 Authors
Source:
Journal of functional foods 2019 v.54 pp. 281-288
ISSN:
1756-4646
Subject:
Panax; Western blotting; acetaldehyde; alcohol drinking; alcohols; enzymes; gene expression; ginsenosides; hepatoprotective effect; inflammation; intragastric administration; lipogenesis; liver; messenger RNA; mice; oxidative stress; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription factors; transcriptomics; wines
Abstract:
... We optimized conditions for preparation of ginseng wine and explored hepatoprotective effects of ginsenosides against alcohol-induced liver injury in mice by transcriptomics analyses. Mice were treated by daily intragastric administration of water, 55%-ethanol, or ginseng-wine. Results showed that mRNA levels of Adh1 and Cyp2e1, which encode the two enzymes involved in the conversion of alcohol to ...
DOI:
10.1016/j.jff.2019.01.014

3. Genetic diversity, virulence factors and farm-to-table spread pattern of Vibrio parahaemolyticus food-associated isolates

Author:
Fan, Hang,   et al.   ; Yang, Chao; Zhang, Xianglilan; Li, Yinghui; Hu, Qinghua; Yang, Ruifu; Cui, Yujun;     Show all 7 Authors
Source:
Food microbiology 2019 v.84 pp. 103270
ISSN:
0740-0020
Subject:
Vibrio parahaemolyticus; farm to fork; food pathogens; food production; freshwater; gastroenteritis; genes; genetic variation; genomic islands; seawater; single nucleotide polymorphism; virulence; China
Abstract:
... Vibrio parahaemolyticus is the leading bacterial cause of seafood-associated gastroenteritis worldwide. Moreover, infections and outbreaks caused by V. parahaemolyticus has kept increasing over the last two decades. In this study, we investigated the genetic diversity, virulence factors and farm-to-table spread pattern of V. parahaemolyticus by analyzing 383 genomes of food-associated isolates. Th ...
DOI:
10.1016/j.fm.2019.103270

4. Characterization and complete genome sequence analysis of phage GP4, a novel lytic Bcep22-like podovirus

Author:
Fan, Hang,   et al.   ; Wang, Ronghuan; Cong, Yu; Mi, Zhiqiang; Shi, Taoxing; Liu, Hui; Tong, Yigang;     Show all 7 Authors
Source:
Archives of virology 2019 v.164 no.9 pp. 2339-2343
ISSN:
0304-8608
Subject:
DNA; Podoviridae; Ralstonia solanacearum; bacteriophages; cysteine; genetic databases; genome; high-throughput nucleotide sequencing; latent period; open reading frames; phylogeny; phylotype; temperature; transfer RNA
Abstract:
... We isolated a novel lytic phage of Ralstonia solanacearum, GP4. The GP4 phage has a latent period of ~ 2 h at its optimal multiplicity of infection and is stable at temperatures ranging from 40–70 °C. GP4 lysed 16 strains of R. solanacearum belonging to phylotype IV. High-throughput sequencing revealed that GP4 has a linear dsDNA genome that consists of 61,129 bp, contains 83 open reading frames, ...
DOI:
10.1007/s00705-019-04309-7

5. Genome sequence of Bacillus anthracis typing phage AP631

Author:
Fan, Hang,   et al.   ; Liu, Xiankai; Wang, Dongshu; Pan, Chao; Feng, Erling; Li, Manli; Zhu, Li; Tong, Yigang; Wang, Hengliang;     Show all 9 Authors
Source:
Archives of virology 2019 v.164 no.3 pp. 917-921
ISSN:
0304-8608
Subject:
Bacillus anthracis; Bacillus cereus; anthrax; bacteria; bacteriophages; circular DNA; coat proteins; enzymes; genes; genomics; nucleotide sequences; phylogeny; ribosomal RNA; sequence homology; transfer RNA; virulence; China
Abstract:
... AP631, a virulent bacteriophage of Bacillus anthracis, is widely used in China to identify anthrax bacteria. In this study, we report the complete AP631 phage genome sequence as well as comparative genomic analysis with other bacteriophages of B. cereus and related species. The double-stranded circular DNA genome of phage AP631 was 39,549 bp in length with 35.01% G + C content. The phage genome co ...
DOI:
10.1007/s00705-018-04135-3

6. Identification of a lytic Pseudomonas aeruginosa phage depolymerase and its anti-biofilm effect and bactericidal contribution to serum

Author:
Fan, Hang,   et al.   ; Mi, Liyuan; Liu, Yannan; Wang, Can; He, Tongtong; Gao, Shan; Xing, Shaozhen; Huang, Yong; Zhang, Xianglilan; Yu, Wengong; Mi, Zhiqiang; Tong, Yigang; Bai, Changqing; Han, Feng;     Show all 14 Authors
Source:
Virus genes 2019 v.55 no.3 pp. 394-405
ISSN:
0920-8569
Subject:
Pseudomonas aeruginosa; anti-infective agents; antibacterial properties; bacteriophages; biofilm; blood serum; catalytic activity; cystic fibrosis; enzymes; exopolysaccharides; hospitals; multiple drug resistance; nucleotide sequences; patients; sequence analysis; sewage
Abstract:
... Pseudomonas aeruginosa (P. aeruginosa) infection has imposed a great threat to patients with cystic fibrosis. With the emergence of multidrug-resistant P. aeruginosa, developing an alternative anti-microbial strategy is indispensable and more urgent than ever. In this study, a lytic P. aeruginosa phage was isolated from the sewage of a hospital, and one protein was predicted as the depolymerase-li ...
DOI:
10.1007/s11262-019-01660-4

7. Expression profiles and clinical value of plasma exosomal Tim-3 and Galectin-9 in non-small cell lung cancer

Author:
Fan, Hang,   et al.   ; Gao, Jianwei; Qiu, Xiangyu; Li, Xinying; Zhang, Fang; Lv, Tangfeng; Song, Yong;     Show all 7 Authors
Source:
Biochemical and biophysical research communications 2018 v.498 no.3 pp. 409-415
ISSN:
0006-291X
Subject:
T-lymphocytes; Western blotting; adenocarcinoma; biomarkers; enzyme-linked immunosorbent assay; exosomes; galectins; immune response; immunoglobulins; ligands; lung neoplasms; lungs; lymph nodes; metastasis; mucins; neoplasm cells; patients; protein content; squamous cell carcinoma; transmission electron microscopy; viruses
Abstract:
... Exosomes are membrane-bound, virus-sized vesicles present in circulating blood. Tumor cells are avid producers of exosomes, which are thought to mimic molecular features of parent tumor cells. T-cell immunoglobulin- and mucin-domain-containing molecule 3 (Tim-3) is a the next-generation immune checkpoint that can be activated by its ligand Galectin-9 to negatively regulate the anti-tumor immune re ...
DOI:
10.1016/j.bbrc.2018.02.114

8. Protective and therapeutic application of the depolymerase derived from a novel KN1 genotype of Klebsiella pneumoniae bacteriophage in mice

Author:
Fan, Hang,   et al.   ; Wang, Can; Li, Puyuan; Niu, Wenkai; Yuan, Xin; Liu, Huiying; Huang, Yong; An, Xiaoping; Zhangxiang, Lilan; Mi, Liyuan; Zheng, Jing; Liu, Yannan; Tong, Yigang; Mi, Zhiqiang; Bai, Changqing;     Show all 15 Authors
Source:
Research in microbiology 2019 v.170 no.3 pp. 156-164
ISSN:
0923-2508
Subject:
Escherichia coli; Gram-negative bacteria; Klebsiella pneumoniae; anti-infective agents; bacteriophages; blood serum; enzymes; genotype; latent period; mice; multiple drug resistance; open reading frames; pathogens; polysaccharides; survival rate; therapeutics
Abstract:
... Klebsiella pneumoniae is one of the major Gram-negative bacterial pathogens causing hospital-acquired multidrug-resistant infections, and the antimicrobial treatment options are scarce. The lack of available antimicrobials has prompted the development of alternative strategies for the treatment of these infections. In this study, a K. pneumoniae bacteriophage (vB_KpnP_IME321) targeting a KN1 capsu ...
DOI:
10.1016/j.resmic.2019.01.003

9. Assessment of the bioactive phenolic composition of Acer truncatum seed coat as a byproduct of seed oil

Author:
Fan, Hang,   et al.   ; Sun, Liwei; Yang, Lingguang; Zhou, Jinchi; Yin, Peipei; Li, Ke; Xue, Qiang; Li, Xiang; Liu, Yujun;     Show all 9 Authors
Source:
Industrial crops and products 2018 v.118 pp. 11-19
ISSN:
0926-6690
Subject:
2,2-diphenyl-1-picrylhydrazyl; 2,5-dihydroxybenzoic acid; Acer truncatum; acetone; antioxidant activity; antioxidants; byproducts; epicatechin; ethanol; manufacturing; naringenin; proanthocyanidins; procyanidins; seed coat; seed oils; tannins; wastes
Abstract:
... Acer truncatum seed coat is generally abandoned as waste during the process of manufacturing seed oil due to a lack of knowledge of the phytochemical composition of this byproduct. It is well known that brown-colored seed coat is rich in polyphenols; therefore, we investigated the bioactive phenolic composition of A. truncatum seed coat in this study. To obtain an extract containing most bioactive ...
DOI:
10.1016/j.indcrop.2018.03.030

10. Comparative evaluations on phenolic antioxidants of nine adulterants and anti-inflammation of four alternatives with their original herb Erycibe schmidtii

Author:
Fan, Hang,   et al.   ; Xue, Qiang; Li, Ke; Yang, Lingguang; Sun, Liwei; Liu, Yujun;     Show all 6 Authors
Source:
RSC advances 2017 v.7 no.81 pp. 51151-51161
ISSN:
2046-2069
Subject:
Celastrus; Morinda; Piper kadsura; adulterants; anti-inflammatory activity; antioxidant activity; antioxidants; flavonoids; herbs; high performance liquid chromatography; inducible nitric oxide synthase; interleukin-1beta; interleukin-6; macrophages; nitric oxide; tannins; traditional medicine; China
Abstract:
... Erycibe schmidtii is widely used as folk medicine in China for treatments of various inflammations. Recently, with reduction of its wild sources, various adulterants have been misused as substitutes. To distinguish reliable alternatives from various adulterants, total phenolics and antioxidant activities of E. schmidtii and its nine adulterants, as well as three marker compounds of E. schmidtii de ...
DOI:
10.1039/c7ra10767f

11. Isolation and identification of terpenoids from chicory roots and their inhibitory activities against yeast α-glucosidase

Author:
Fan, Hang,   et al.   ; Chen, Jian; Lv, Han; Ao, Xiancan; Wu, Yuexian; Ren, Bingru; Li, Weilin;     Show all 7 Authors
Source:
European food research & technology 2017 v.243 no.6 pp. 1009-1017
ISSN:
1438-2377
Subject:
Cichorium intybus; alpha-glucosidase; chemical structure; chicory; glycemic effect; inhibitory concentration 50; roots; sesquiterpenoids; traditional medicine; yeasts; China; Europe; North America
Abstract:
... Chicory (Cichorium intybus L.var. sativum L., Asteraceae) is a multipurpose plant cultivated as vegetable and coffee substitute in Europe and North America, also as folk medicine in China. The extracts from chicory roots showed significant effect on inhibition against α-glucosidase. By a bioassay-guided approach, the chemical fraction with high α-glucosidase inhibition was found and its chemical p ...
DOI:
10.1007/s00217-016-2810-1

12. Investigation on Mosquito-Borne Viruses at Lancang River and Nu River Watersheds in Southwestern China

Author:
Fan, Hang,   et al.   ; Li, Lingli; Guo, Xiaofang; Zhao, Qiumin; Tong, Yigang; Sun, Qiang; Xing, Shaozhen; Zhou, Hongning; Zhang, Jiusong;     Show all 9 Authors
Source:
Vector borne and zoonotic diseases 2017 v.17 no.12 pp. 804-812
ISSN:
1557-7759
Subject:
Anopheles minimus; Anopheles sinensis; Banna virus; Culex tritaeniorhynchus; Getah virus; Iridovirus; Japanese encephalitis virus; Orbivirus; Totivirus; arboviruses; basins; human diseases; insect surveys; pathogens; rivers; viral encephalitis; watersheds; China
Abstract:
... During 2007 and 2010, an extensive entomological survey was performed to assess the distribution of mosquitoes and mosquito-borne arboviruses at Lancang River and Nu River watersheds in southwestern China. A total of 20,450 mosquitoes consisting 20 species was trapped and submitted 261 pools according to species and location. Culex tritaeniorhynchus and Anopheles sinensis were the most abundant sp ...
DOI:
10.1089/vbz.2017.2164

13. Experimental study of dust emission: Comparison between high-temperature and ambient-temperature materials

Author:
Fan, Hang,   et al.   ; Wang, Yi; Duan, Mengjie; Ren, Xiaofen; Qu, Xinrui; Cao, Yingxue; Yang, Yang; Chu, Zongkun;     Show all 8 Authors
Source:
Powder technology 2016 v.301 pp. 1321-1329
ISSN:
0032-5910
Subject:
ambient temperature; dust emissions; powders
Abstract:
... The generation of dust during the handling of high-temperature materials, which fall or impact contact surfaces, can be a significant source of danger for the health of operators. A greater knowledge on the effective control of these falling and impact processes must be illustrated. This paper presents recent experimental research on the characteristics and dust generation rates of materials of di ...
DOI:
10.1016/j.powtec.2016.08.014

14. First complete genome sequence of a virulent bacteriophage infecting the opportunistic pathogen Serratia rubidaea

Author:
Fan, Hang,   et al.   ; Xing, Shaozhen; Ma, Taping; Zhang, Xianglilan; Huang, Yong; Mi, Zhiqiang; Sun, Qiang; An, Xiaoping; Wu, Shuhui; Wei, Lin; Tong, Yigang;     Show all 11 Authors
Source:
Archives of virology 2017 v.162 no.7 pp. 2021-2028
ISSN:
0304-8608
Subject:
DNA; Klebsiella; Myoviridae; Serratia rubidaea; bacteriophages; genome; high-throughput nucleotide sequencing; hospitals; nucleotide sequences; nucleotides; secondary infection; sewage; virulence
Abstract:
... A Serratia rubidaea phage, vB_Sru IME250, was isolated from hospital sewage. The morphology suggested that phage vB_Sru IME250 should be classified as a member of the family Myoviridae. High-throughput sequencing revealed that the phage genome has 154,938 nucleotides and consists of 193 coding DNA sequences, 90 of which have putative functions. The genome of vB_Sru IME250 is a linear, double-stran ...
DOI:
10.1007/s00705-017-3300-x

15. Novel sub-lineages, recombinants and reassortants of severe fever with thrombocytopenia syndrome virus

Author:
Fan, Hang,   et al.   ; Lv, Qiang; Zhang, Hong; Tian, Lei; Zhang, Ruiling; Zhang, Zhenjie; Li, Juan; Tong, Yigang; Carr, Michael J.; Shi, Weifeng;     Show all 10 Authors
Source:
Ticks and tick-borne diseases 2017 v.8 no.3 pp. 385-390
ISSN:
1877-959X
Subject:
antiviral agents; fever; genes; genetic variation; genotype; monitoring; pathogenicity; pathogens; phylogeny; public health; thrombocytopenia; tick-borne diseases; ticks; vaccines; viruses; China
Abstract:
... Severe fever with thrombocytopenia syndrome virus (SFTSV) has been continuously circulating in Eastern Asia in recent years, without the availability of effective vaccines or antiviral drugs, posing a serious threat to public health, particularly in the central-eastern provinces of China. In this study, we isolated and sequenced four new SFTSV strains from Shandong Province identified in 2015. Phy ...
DOI:
10.1016/j.ttbdis.2016.12.015

16. Experimental study of flow regimes and dust emission in a free falling particle stream

Author:
Fan, Hang,   et al.   ; Wang, Yi; Ren, Xiaofen; Zhao, Jiangping; Chu, Zongkun; Cao, Yingxue; Yang, Yang; Duan, Mengjie; Qu, Xinrui;     Show all 9 Authors
Source:
Powder technology 2016 v.292 pp. 14-22
ISSN:
0032-5910
Subject:
dust; dust emissions; equations; powders
Abstract:
... The flow regimes in a free falling particle stream and the dust emission rate are experimentally explored in this paper. The results show that the particle stream could be divided successively into the stable regime, the transitive regime and the dispersive regime. The length of each regime is quantitatively identified. In our testing range, the dust emission rate (ηr) increases monotonically with ...
DOI:
10.1016/j.powtec.2016.01.016

17. Complete genome sequence of Menghai flavivirus, a novel insect-specific flavivirus from China

Author:
Fan, Hang,   et al.   ; Zhang, Xianglilan; Guo, Xiaofang; Zhao, Qiumin; Zuo, Shuqing; Sun, Qiang; Pei, Guangqian; Cheng, Shi; An, Xiaoping; Wang, Yunfei; Mi, Zhiqiang; Huang, Yong; Zhang, Zhiyi; Tong, Yigang; Zhou, Hongning; Zhang, Jiusong;     Show all 16 Authors
Source:
Archives of virology 2017 v.162 no.5 pp. 1435-1439
ISSN:
0304-8608
Subject:
Aedes albopictus; Flavivirus; arboviruses; genome; nucleotides; phylogeny; polyproteins; screening; sequence analysis; structural proteins; viral nonstructural proteins; China
Abstract:
... Menghai flavivirus (MFV) was isolated from Aedes albopictus in Menghai county of Yunnan Province, China, during an arboviruses screening program in August 2010. Whole genome sequencing of MFV was performed using an Ion PGM™ Sequencer. The complete genome of MFV was 10897 nucleotides in length and encoded a polyprotein and fairly interesting flavivirus orf (FIFO). The polyprotein contained three fl ...
DOI:
10.1007/s00705-017-3232-5

18. Complete genome sequence of Xishuangbanna flavivirus, a novel mosquito-specific flavivirus from China

Author:
Fan, Hang,   et al.   ; Zhao, Qiumin; Guo, Xiaofang; Sun, Qiang; Zuo, Shuqing; Wu, Chao; Zhou, Hongning; An, Xiaoping; Pei, Guangqian; Tong, Yigang; Zhang, Jiusong; Shi, Taoxing;     Show all 12 Authors
Source:
Archives of virology 2016 v.161 no.6 pp. 1723-1727
ISSN:
0304-8608
Subject:
Aedes albopictus; Flavivirus; RNA; genome; host range; open reading frames; phylogeny; polyproteins; sequence analysis; viruses; China
Abstract:
... A new flavivirus, Xishuangbanna flavivirus (XFV), infecting Aedes albopictus mosquitoes in Yunnan Province, China, was isolated and sequenced. The single-stranded RNA genome of 10,884 nt contained two open reading frames (ORFs) encoding the polyprotein and FIFO. The genome had a maximum nucleotide sequence identity of 65 % to Parramatta River virus with coverage of only 27 %. Phylogenetic analysis ...
DOI:
10.1007/s00705-016-2827-6

19. Genome analysis of Enterococcus faecalis bacteriophage IME-EF3 harboring a putative metallo-beta-lactamase gene

Author:
Fan, Hang,   et al.   ; Li, Xiaoyu; Ding, Peng; Han, Chuanyin; Wang, Yahui; Mi, Zhiqiang; Feng, Fumin; Tong, Yigang;     Show all 8 Authors
Source:
Virus genes 2014 v.49 no.1 pp. 145-151
ISSN:
0920-8569
Subject:
DNA; Enterococcus faecalis; Siphoviridae; bacteriophages; electron microscopy; genes; genomics; high-throughput nucleotide sequencing; horizontal gene transfer; multiple drug resistance; proteins; sewage; therapeutics; transcription (genetics)
Abstract:
... Lytic Enterococcus faecalis bacteriophage IME-EF3 was isolated from hospital sewage, and its genome was sequenced using high-throughput sequencing. Genomic analysis and electron microscopy suggested that IME-EF3 was a member of the family Siphoviridae. The phage has an isometric head and a long non-contractile tail with a 41 kb linear double-stranded DNA genome. The genome encodes 69 putative prot ...
DOI:
10.1007/s11262-014-1079-3
PubMed:
24818695

20. Complete Genome Sequence of Avian Influenza Virus A/chicken/Jiangsu/1001/2013(H5N2), Demonstrating Continuous Reassortance of H5N2 in China

Author:
Fan, Hang,   et al.   ; Mi, Zhiqiang; Liu, Wei; An, Xiaoping; Pei, Guangqian; Wang, Wei; Xu, Xiaomeng; Ma, Maijuan; Zhang, Zhiyi; Cao, Wuchun; Tong, Yigang;     Show all 11 Authors
Source:
Genome announcements 2013 v.1 no.4 pp. e00469-13
ISSN:
2169-8287
Subject:
Influenza A virus; chickens; markets; nucleotide sequences; viruses; China
Abstract:
... Avian influenza virus A/chicken/Jiangsu/1001/2013(H5N2) was identified from a healthy chicken in an eastern China poultry market. Whole-genome analysis demonstrated that the H5N2 virus originated from a reassortance between a previous A/chicken/Hebei/1102/2010(H5N2) virus and an endemic H5N1 virus. The results indicated that continuing reassortance of H5N2 has been occurring in domestic poultry of ...
DOI:
10.1128/genomeA.00469-13