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- Rutherford, Mark S., et al. Show all 4 Authors
- Veterinary microbiology 2010 v.146 no.1-2 pp. 111-117
- cattle; Bacillus anthracis; anthrax; bacterial toxins; biochemical pathways; transcription factors; tumor necrosis factor-alpha; macrophages; cell lines; dosage; dose response; cell death; active transport; signal transduction; caspases
- ... Anthrax lethal toxin (LeTx) is an important virulence factor of Bacillus anthracis and causes illness and lethality for both animals and humans. Because species demonstrate varied sensitivity to anthrax intoxication, we investigated signaling pathways involved in anthrax LeTx cytotoxicity using a bovine macrophage cell line (BoMac). We found that bovine macrophages are sensitive to LeTx as display ...
- Rutherford, Mark S., et al. Show all 10 Authors
- Animal biotechnology 2012 v.23 no.1 pp. 43-63
- Meishan; Pietrain; alleles; average daily gain; carcass characteristics; cardiovascular diseases; chromosomes; color; corpus luteum; genetic background; genetic disorders; genetic variation; gestation period; livestock breeding; livestock production; parturition; quantitative trait loci; reproductive traits; single nucleotide polymorphism; skeletal development; swine; transforming growth factor beta
- ... Background: Growth and carcass traits are of great economic importance in livestock production. A large number of quantitative trait loci (QTL) have been identified for growth and carcass traits on porcine chromosome one (SSC1). A key positional candidate for this chromosomal region is TGFBR1 (transforming growth factor beta type I receptor). This gene plays a key role in inherited disorders at ca ...
- Rutherford, Mark S., et al. Show all 5 Authors
- Veterinary dermatology 2009 v.20 no.1 pp. 19-26
- immunity; polypeptides; antimicrobial properties; body regions; normal values; dogs; reverse transcriptase polymerase chain reaction; gene expression; genes; disease resistance; proteinase inhibitors; genomics; animal genetics
- ... The cutaneous barrier contains small, cationic antimicrobial peptides that participate in the innate immunity against a wide variety of pathogens. Despite their immune importance, knowledge of canine defensins and their expression is limited primarily to testicular tissue and their relation to coat colour. Studies have shown that the absence of these antimicrobial peptides contribute to increased ...